{"title":"From the editorial office","authors":"N. S. Kuznetsov","doi":"10.14341/serg12793","DOIUrl":"https://doi.org/10.14341/serg12793","url":null,"abstract":".","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135792582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Choinzonov, I. Reshetov, S. A. Ivanov, A. Polyakov, M. Kropotov, A. Mudunov, V. Polkin, P. Isaev, A. Ilyin, D. G. Beltsevich, V. Vanushko, P. Rumyantsev, G. Melnichenko, Y. Alymov, I. S. Romanov, A. V. Ignatova, E. Borodavina, V. Krylov, A. Shurinov, N. Severskaya, Z. Radjabova, D. Kulbakin, A. Nevolskikh, A. Gevorkov, E. Khmelevsky, S. Kutukova, A. Guz, I. Sleptsov, R. Chernikov, A. Stepanova, N. Falaleeva, S. Podvyaznikov, N. Rubtsova, A. N. Rudyk, S. Musin, I. Gulidov, L. Vladimirova, T. Semiglazova, T. A. Aghababyan, E. Kostromina
The article presents a draft of clinical recommendations for the diagnosis and treatment of differentiated thyroid cancer in adult patients, which provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches.
{"title":"Draft of clinical guidelines for the diagnosis and treatment of differentiated thyroid cancer in adult patients","authors":"E. Choinzonov, I. Reshetov, S. A. Ivanov, A. Polyakov, M. Kropotov, A. Mudunov, V. Polkin, P. Isaev, A. Ilyin, D. G. Beltsevich, V. Vanushko, P. Rumyantsev, G. Melnichenko, Y. Alymov, I. S. Romanov, A. V. Ignatova, E. Borodavina, V. Krylov, A. Shurinov, N. Severskaya, Z. Radjabova, D. Kulbakin, A. Nevolskikh, A. Gevorkov, E. Khmelevsky, S. Kutukova, A. Guz, I. Sleptsov, R. Chernikov, A. Stepanova, N. Falaleeva, S. Podvyaznikov, N. Rubtsova, A. N. Rudyk, S. Musin, I. Gulidov, L. Vladimirova, T. Semiglazova, T. A. Aghababyan, E. Kostromina","doi":"10.14341/serg12792","DOIUrl":"https://doi.org/10.14341/serg12792","url":null,"abstract":"The article presents a draft of clinical recommendations for the diagnosis and treatment of differentiated thyroid cancer in adult patients, which provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42637758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From the editorial office","authors":"N. S. Kuznetsov","doi":"10.14341/serg12795","DOIUrl":"https://doi.org/10.14341/serg12795","url":null,"abstract":".","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135792581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Sleptsov, R. Chernikov, A. Pushkaruk, I. Sablin, T. Tilloev, N. Timofeeva, K. Gerasimova, D. Buzanakov, S. Shikhmagomedov, S. Alekseeva, A. Bubnov, Yana Osokina, M. V. Liubimov
BACKGROUND: One of the most important tasks in thyroid surgery is to prevent the development of specific complications — laryngeal nerve dysfunction and hypoparathyroidism. A significant number of technical solutions introduced into clinical practice in recent years are aimed at solving this problem.AIM: Тo evaluate the results of an alternative technique of thyroid surgery — medial thyroidectomy.MATERIALS AND METHODS: 270 patients with thyroid diseases were operated on using tension free thyroidectomy technique in the volume of hemi- or thyroidectomy with or without cervical lymphadenectomy. The selection of patients was continuous. All patients underwent ultrasound or videolaryngoscopy before the operation and on the 1st postoperative day. Patients who underwent thyroidectomy underwent blood analysis for parathormone and blood analysis for ionized calcium.RESULTS: For hemithyroidectomy the duration of surgery did not change. In the group of patients with nodes up to 30 mm the duration of surgery increased. An increase in the operation time was also noted for thyroidectomy. Unilateral laryngeal paresis was registered in 6 (2.3%) patients or 1.7% of the number of recurrent laryngeal nerves in the risk area. The risk of parathyroid gland (PTG) removal was 0.39% of the number of operations and 0.14% of the number of PTG in the risk area. Decrease in the level of parathormone in the first day after surgery was noted in 11.5% of patients. The development of postoperative hematoma was noted in 1 patient (0.39%).CONCLUSION: The technique of thyroid surgery with medial access to the recurrent laryngeal nerve and parathyroid glands is feasible in the vast majority of patients with thyroid diseases requiring surgical treatment and shows high safety and a number of advantages over the traditional method of thyroid surgery.
{"title":"Tension-free thyroidectomy (TFT, medial thyroidectomy) — a prospective study: surgical technique and results of 259 operations","authors":"I. Sleptsov, R. Chernikov, A. Pushkaruk, I. Sablin, T. Tilloev, N. Timofeeva, K. Gerasimova, D. Buzanakov, S. Shikhmagomedov, S. Alekseeva, A. Bubnov, Yana Osokina, M. V. Liubimov","doi":"10.14341/serg12774","DOIUrl":"https://doi.org/10.14341/serg12774","url":null,"abstract":"BACKGROUND: One of the most important tasks in thyroid surgery is to prevent the development of specific complications — laryngeal nerve dysfunction and hypoparathyroidism. A significant number of technical solutions introduced into clinical practice in recent years are aimed at solving this problem.AIM: Тo evaluate the results of an alternative technique of thyroid surgery — medial thyroidectomy.MATERIALS AND METHODS: 270 patients with thyroid diseases were operated on using tension free thyroidectomy technique in the volume of hemi- or thyroidectomy with or without cervical lymphadenectomy. The selection of patients was continuous. All patients underwent ultrasound or videolaryngoscopy before the operation and on the 1st postoperative day. Patients who underwent thyroidectomy underwent blood analysis for parathormone and blood analysis for ionized calcium.RESULTS: For hemithyroidectomy the duration of surgery did not change. In the group of patients with nodes up to 30 mm the duration of surgery increased. An increase in the operation time was also noted for thyroidectomy. Unilateral laryngeal paresis was registered in 6 (2.3%) patients or 1.7% of the number of recurrent laryngeal nerves in the risk area. The risk of parathyroid gland (PTG) removal was 0.39% of the number of operations and 0.14% of the number of PTG in the risk area. Decrease in the level of parathormone in the first day after surgery was noted in 11.5% of patients. The development of postoperative hematoma was noted in 1 patient (0.39%).CONCLUSION: The technique of thyroid surgery with medial access to the recurrent laryngeal nerve and parathyroid glands is feasible in the vast majority of patients with thyroid diseases requiring surgical treatment and shows high safety and a number of advantages over the traditional method of thyroid surgery.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44741647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Chevais, A. Elfimova, D. Derkatch, A. Romanova, A. K. Ebzeeva
BACKGROUND: To date, surgical treatment is an effective treatment of hypercortisolism in primary bilateral macronodular hyperplasia (PBMAH). Due to the bilateral lesion, the most common treatment in Russia is the bilateral adrenalectomy, which requires the appointment of hormone replacement therapy. The results of various studies on the effectiveness of unilateral adrenalectomy (UA) in PBMAH are rather discordant.AIM: The objective of the study was to assess the outcomes of UA in patients with PBMAH, accompanied by mild autonomous cortisol excess (MACE) or overt Cushing’s syndrome (CS).MATERIALS AND METHODS: 44 patients with PBMAH and a manifest form of CS (n=21) MACE with comorbid conditions (n=23) underwent UA in the surgical department of the Endocrinology Research Centre. The dynamics of laboratory parameters (cortisol after overnight dexamethasone suppression test (cortisol ONDST) urinary free cortisol (СКМ), ACTH), as well as the course of comorbid diseases (diabetes mellitus, arterial hypertension (AH), metabolic disorders) were assessed before and after 6 months of surgical intervention. The cut-off level of blood cortisol (8:00–9:00) during the first day after OA was determined as a predictor of the development of adrenal insufficiency (AI) in the early postoperative period.RESULTS: 6 months after OA, laboratory parameters improved in 40/44 (91%, 95% CI: 78%-97%) cases: cortisol ONDST decreased from 466 [173; 652] to 86 [61; 149] nmol/l, p=<0.01, СКМ dropped from 840 [468; 1892] to 267 [204; 432] nmol/day, p=<0.01), while ACTH increased gradually from 1 [1; 2.1] to 8.3 [2.6; 15.0] pg/ml, p=<0.01), which indicates the effectiveness of UA. Statistically significant changes in BMI were also obtained (before UA — 30.8 [27.5; 34.4], after — 28.5 [23.9; 32.2] kg/m2 (p <0.01)). When analyzing the long-term outcomes of UA on carbohydrate metabolism, a decrease in the level of HbA1c from 7.0 [6.3; 7.7] to 6.0 [5.6; 6.7] %, (p<0.01) was observed. Further, there was an improvement in the course of AH. After UA, antihypertensive therapy was completely discontinued in 27.7% of cases, and a reduction in the number of antihypertensive drugs was carried out in 44.4%. The level of cortisol in the early postoperative period less than 325 nmol/l was the strongest factor predicting the potential adrenal failure (AUC=0.96).CONCLUSION: UA can be recommended as the first line treatment of PBMAH with CS due to the high probability of longterm remission of hypercortisolism and improvement in the course of comorbid diseases.
{"title":"Unilateral adrenalectomy for primary bilateral macronodular adrenal hyperplasia","authors":"A. Chevais, A. Elfimova, D. Derkatch, A. Romanova, A. K. Ebzeeva","doi":"10.14341/serg12779","DOIUrl":"https://doi.org/10.14341/serg12779","url":null,"abstract":"BACKGROUND: To date, surgical treatment is an effective treatment of hypercortisolism in primary bilateral macronodular hyperplasia (PBMAH). Due to the bilateral lesion, the most common treatment in Russia is the bilateral adrenalectomy, which requires the appointment of hormone replacement therapy. The results of various studies on the effectiveness of unilateral adrenalectomy (UA) in PBMAH are rather discordant.AIM: The objective of the study was to assess the outcomes of UA in patients with PBMAH, accompanied by mild autonomous cortisol excess (MACE) or overt Cushing’s syndrome (CS).MATERIALS AND METHODS: 44 patients with PBMAH and a manifest form of CS (n=21) MACE with comorbid conditions (n=23) underwent UA in the surgical department of the Endocrinology Research Centre. The dynamics of laboratory parameters (cortisol after overnight dexamethasone suppression test (cortisol ONDST) urinary free cortisol (СКМ), ACTH), as well as the course of comorbid diseases (diabetes mellitus, arterial hypertension (AH), metabolic disorders) were assessed before and after 6 months of surgical intervention. The cut-off level of blood cortisol (8:00–9:00) during the first day after OA was determined as a predictor of the development of adrenal insufficiency (AI) in the early postoperative period.RESULTS: 6 months after OA, laboratory parameters improved in 40/44 (91%, 95% CI: 78%-97%) cases: cortisol ONDST decreased from 466 [173; 652] to 86 [61; 149] nmol/l, p=<0.01, СКМ dropped from 840 [468; 1892] to 267 [204; 432] nmol/day, p=<0.01), while ACTH increased gradually from 1 [1; 2.1] to 8.3 [2.6; 15.0] pg/ml, p=<0.01), which indicates the effectiveness of UA. Statistically significant changes in BMI were also obtained (before UA — 30.8 [27.5; 34.4], after — 28.5 [23.9; 32.2] kg/m2 (p <0.01)). When analyzing the long-term outcomes of UA on carbohydrate metabolism, a decrease in the level of HbA1c from 7.0 [6.3; 7.7] to 6.0 [5.6; 6.7] %, (p<0.01) was observed. Further, there was an improvement in the course of AH. After UA, antihypertensive therapy was completely discontinued in 27.7% of cases, and a reduction in the number of antihypertensive drugs was carried out in 44.4%. The level of cortisol in the early postoperative period less than 325 nmol/l was the strongest factor predicting the potential adrenal failure (AUC=0.96).CONCLUSION: UA can be recommended as the first line treatment of PBMAH with CS due to the high probability of longterm remission of hypercortisolism and improvement in the course of comorbid diseases.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41675477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. B. Duboshina, V. Meshcheryakov, S. Kapralov, V. Yakubenko, E. V. Amirov, I. Turlykova, Y. Vanzha
The article tells about the work and scientific achievements of Professor K.I. Myshkin — surgeon, founder of the school of endocrine surgery, teacher, whose example has become a guide for many on their professional path. Materials about the biography of the great professional, information about the continuation of his scientific achievements by his students and followers are given.
{"title":"The history of the development of endocrine surgery in Saratov: professor Myshkin K.I. is the founder of the school of endocrine surgery","authors":"T. B. Duboshina, V. Meshcheryakov, S. Kapralov, V. Yakubenko, E. V. Amirov, I. Turlykova, Y. Vanzha","doi":"10.14341/serg12722","DOIUrl":"https://doi.org/10.14341/serg12722","url":null,"abstract":"The article tells about the work and scientific achievements of Professor K.I. Myshkin — surgeon, founder of the school of endocrine surgery, teacher, whose example has become a guide for many on their professional path. Materials about the biography of the great professional, information about the continuation of his scientific achievements by his students and followers are given.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43653743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The availability of modern high-precision diagnostic methods increased the detection rate of pancreatic neuroendocrine neoplasia (pNEN). There is no doubt concerning the necessity of surgical treatment for localized functioning tumors, whilecurrently there is no objective way to choose the tactic for non-functioning asymptomatic neuroendocrine tumors of the pancreas (pNET) with the exception of the tumor size.Treatment tactics for non-functioning asymptomatic T1 neuroendocrine tumors (less 2 cm in size) are debatable. According to literature surgical treatment for lesions less than 2 cm does not always increase survival. In the same time even in high-volume centers pancreatic surgery shows high morbidity and mortality rate. Prospective randomized trials comparing surveillance and operative treatment are not published yet, as far as authors concerned. International guidelines answer the question of treatment such neoplasms ambiguously, while national Russian recommendations do not cover the topic. Guidelines are based on heterogeneous retrospective studies; therefore, the aim of scientific research is to determine reliable criteria for patient selection for dynamic observation or surgical treatment.This article provides an overview of 60 scientific publications covering the problem.
{"title":"Pancreatic resections or observation in management of sporadic non-functioning stage T1 neuroendocrine tumors of the pancreas (PNET) (literature review)","authors":"D. Salimgereeva, I. Feidorov, I. Khatkov","doi":"10.14341/serg12775","DOIUrl":"https://doi.org/10.14341/serg12775","url":null,"abstract":"The availability of modern high-precision diagnostic methods increased the detection rate of pancreatic neuroendocrine neoplasia (pNEN). There is no doubt concerning the necessity of surgical treatment for localized functioning tumors, whilecurrently there is no objective way to choose the tactic for non-functioning asymptomatic neuroendocrine tumors of the pancreas (pNET) with the exception of the tumor size.Treatment tactics for non-functioning asymptomatic T1 neuroendocrine tumors (less 2 cm in size) are debatable. According to literature surgical treatment for lesions less than 2 cm does not always increase survival. In the same time even in high-volume centers pancreatic surgery shows high morbidity and mortality rate. Prospective randomized trials comparing surveillance and operative treatment are not published yet, as far as authors concerned. International guidelines answer the question of treatment such neoplasms ambiguously, while national Russian recommendations do not cover the topic. Guidelines are based on heterogeneous retrospective studies; therefore, the aim of scientific research is to determine reliable criteria for patient selection for dynamic observation or surgical treatment.This article provides an overview of 60 scientific publications covering the problem.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45491367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Sergiiko, D. V. Korotovsky, V. L. Tul`ganova, I. V. Lomova, A. S. Butorin
We present a clinical case of 22yo patient with diagnosis of pheochoromocytoma complicated with myelodysplastic syndrome as manifestation of paraneoplastic phenomenon. The onset of the disease displays typical clinical picture of pheochromacytoma. After medical examination and survey it was discovered a tumor in left adrenal gland and elevation of metanephrines and normetanephrines. In addition, patient has severe anemia and thrombocytopenia. Sternal punction with morphological examination and immunophenotyping were performed. Patient had consulted by hematologist. After all additional analysis cause of anemia and thrombocytopenia remained unknown and related to presence of tumor.Patient was performed a long-time and vast pre-operative preparation with administration of doxazosin and transfusions of blood and platelet concentrate. In continuation, mass in left adrenal gland was excised with spleen by thoracophrenolaparotomy. Morphology confirmed pheochromacytoma, which has typical histological structure and circulatory disorders. Spleen has no specifical features except of focuses of extramedullar hematopoiesis. Patient has short period of hormone therapy to avoid adrenal crisis on post-operative stage. Also massive transfutions of blood and platelet concentrate was performed due to persisting anemia and thrombocytopenia. There were no manifestations of hemorrhage syndrome after the surgery. Myelodysplastic syndrome was detected 3 month later and manifested itself in form of refractory anemia and severe thrombocytopenia, which persisted for long period and required corrections with therapy and transfusions. Only through 5-year observation after adrenalectomy patient has positive dynamic and leveling of laboratory tests without symptoms of myelodysplastic syndrome.
{"title":"Pheochromocytoma with paraneoplastic phenomena manifested as myelodysplastic syndrome","authors":"S. Sergiiko, D. V. Korotovsky, V. L. Tul`ganova, I. V. Lomova, A. S. Butorin","doi":"10.14341/serg12771","DOIUrl":"https://doi.org/10.14341/serg12771","url":null,"abstract":"We present a clinical case of 22yo patient with diagnosis of pheochoromocytoma complicated with myelodysplastic syndrome as manifestation of paraneoplastic phenomenon. The onset of the disease displays typical clinical picture of pheochromacytoma. After medical examination and survey it was discovered a tumor in left adrenal gland and elevation of metanephrines and normetanephrines. In addition, patient has severe anemia and thrombocytopenia. Sternal punction with morphological examination and immunophenotyping were performed. Patient had consulted by hematologist. After all additional analysis cause of anemia and thrombocytopenia remained unknown and related to presence of tumor.Patient was performed a long-time and vast pre-operative preparation with administration of doxazosin and transfusions of blood and platelet concentrate. In continuation, mass in left adrenal gland was excised with spleen by thoracophrenolaparotomy. Morphology confirmed pheochromacytoma, which has typical histological structure and circulatory disorders. Spleen has no specifical features except of focuses of extramedullar hematopoiesis. Patient has short period of hormone therapy to avoid adrenal crisis on post-operative stage. Also massive transfutions of blood and platelet concentrate was performed due to persisting anemia and thrombocytopenia. There were no manifestations of hemorrhage syndrome after the surgery. Myelodysplastic syndrome was detected 3 month later and manifested itself in form of refractory anemia and severe thrombocytopenia, which persisted for long period and required corrections with therapy and transfusions. Only through 5-year observation after adrenalectomy patient has positive dynamic and leveling of laboratory tests without symptoms of myelodysplastic syndrome.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47796143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Currently, surgical methods of treatment are increasingly used to achieve remission of diabetes mellitus associated with obesity: laparoscopic gastric bypass, longitudinal resection of the stomach and others. In clinical practice, after this type of surgical intervention, patients often experience changes in taste habits and violations of tolerance to foods, nausea, vomiting, intolerance to the smell, type and texture of food. This review summarizes research data on the factors influencing changes in the gut and salivary microbiota, on the impact of microbiota composition on the development of obesity, on changes in taste habits in patients after bariatric surgery, and on possible causes of changes. To search for sources, Internet resources PubMed, Google Scholar, eLIBRARY.ru were used for the last 10 years, to access the full text of articles, the websites of publishers Springer, Elsevier and others were used. According to the search results, 101 sources were analyzed, 60 of them are included in this review.
{"title":"Microbiota as a factor influencing the change in taste preferences after bariatric surgery","authors":"F. Dzgoeva, N. V. Silina","doi":"10.14341/serg12755","DOIUrl":"https://doi.org/10.14341/serg12755","url":null,"abstract":"Currently, surgical methods of treatment are increasingly used to achieve remission of diabetes mellitus associated with obesity: laparoscopic gastric bypass, longitudinal resection of the stomach and others. In clinical practice, after this type of surgical intervention, patients often experience changes in taste habits and violations of tolerance to foods, nausea, vomiting, intolerance to the smell, type and texture of food. This review summarizes research data on the factors influencing changes in the gut and salivary microbiota, on the impact of microbiota composition on the development of obesity, on changes in taste habits in patients after bariatric surgery, and on possible causes of changes. To search for sources, Internet resources PubMed, Google Scholar, eLIBRARY.ru were used for the last 10 years, to access the full text of articles, the websites of publishers Springer, Elsevier and others were used. According to the search results, 101 sources were analyzed, 60 of them are included in this review.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42131911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Markova, D. G. Beltsevich, E. A. Kalinicheva, A. Koshkodan, N. M. Salavatova, K. A. Gaunova
Amiodarone is an antiarrhythmic drug that is widely used in clinical practice to control various types of arrhythmias. One of the most significant side effects of amiodarone therapy is thyroid dysfunction, which is observed in about 15–20% of patients. This article presents a clinical case of a 55-year-old patient with a paroxysmal form of atrial fibrillation, for which amiodarone therapy was performed with the development of manifest amiodarone-induced thyrotoxicosis, refractory to drug therapy with glucocorticosteroids and thyrostatics. Due to the ineffectiveness of drug therapy, a total thyroidectomy was performed, which led to a rapid resolution of thyrotoxicosis and normalization of the heart rhythm.
{"title":"Features of managing patients with amiodarone-induced thyrotoxicosis in real clinical practice","authors":"T. Markova, D. G. Beltsevich, E. A. Kalinicheva, A. Koshkodan, N. M. Salavatova, K. A. Gaunova","doi":"10.14341/serg12732","DOIUrl":"https://doi.org/10.14341/serg12732","url":null,"abstract":"Amiodarone is an antiarrhythmic drug that is widely used in clinical practice to control various types of arrhythmias. One of the most significant side effects of amiodarone therapy is thyroid dysfunction, which is observed in about 15–20% of patients. This article presents a clinical case of a 55-year-old patient with a paroxysmal form of atrial fibrillation, for which amiodarone therapy was performed with the development of manifest amiodarone-induced thyrotoxicosis, refractory to drug therapy with glucocorticosteroids and thyrostatics. Due to the ineffectiveness of drug therapy, a total thyroidectomy was performed, which led to a rapid resolution of thyrotoxicosis and normalization of the heart rhythm.","PeriodicalId":30783,"journal":{"name":"Endokrinnaia khirurgiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41683596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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