{"title":"Australasian Society of Cardio-Vascular Perfusionists Inc. 17th Annual Scientific Meeting","authors":"","doi":"10.1051/ject/2001333197","DOIUrl":"https://doi.org/10.1051/ject/2001333197","url":null,"abstract":"","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115606660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eighty patients were entered in a randomized, doubleblinded, prospective trial to study the benefits of a new surface modification (SMARxT, Cobe Cardiovascular) on neurologic protection. Cardiotomy suction was avoided. Cerebral ischemia markers were similar in both groups but cognitive testing demonstrated a slight improvement in the coated circuit group. The authors warn that showing subtle, yet significant, improvements in clinical outcomes is difficult.
{"title":"Articles of Interest","authors":"Rick G. Smith","doi":"10.1051/ject/200537324","DOIUrl":"https://doi.org/10.1051/ject/200537324","url":null,"abstract":"Eighty patients were entered in a randomized, doubleblinded, prospective trial to study the benefits of a new surface modification (SMARxT, Cobe Cardiovascular) on neurologic protection. Cardiotomy suction was avoided. Cerebral ischemia markers were similar in both groups but cognitive testing demonstrated a slight improvement in the coated circuit group. The authors warn that showing subtle, yet significant, improvements in clinical outcomes is difficult.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132839311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“The whole of science is nothing more than a refinement of everyday thinking.”","authors":"A. Stammers","doi":"10.1051/ject/200133278","DOIUrl":"https://doi.org/10.1051/ject/200133278","url":null,"abstract":"","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132023208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thirty-three years ago, a fledgling group of individuals identified the need for a publication devoted to the field extracorporeal circulation. These pioneers were drawn from numerous disciplines that included dialysis technicians, cardiovascular research laboratories, and allied health fields, yet were unified through a common goal: A commitment to grasp a fuller understanding of the intricacies of blood flow outside of the body. They were unencumbered by neither the temptations of finance, nor by ego, since cardiac surgery, with the use of the heart-lung machine, had yet to experience the tremendous growth that soon followed. Having joined the field since that time, I can only summize that their motivations were genuine—focused totally upon the unifying goal of improving patient care. Regardless, they ushered in a new era with the creation of the first formal publication dedicated to the field of perfusion: the Journal of ExtraCorporeal Technology.
33年前，一群羽翼未丰的人认为有必要出版一本专门研究体外循环领域的出版物。这些先驱者来自众多学科，包括透析技术人员、心血管研究实验室和相关的健康领域，但他们通过一个共同的目标统一起来:致力于更全面地了解体外血液流动的复杂性。他们既没有受到金钱的诱惑，也没有受到自我的束缚，因为使用心肺机的心脏手术尚未经历随后的巨大增长。从那时起我就加入了这个领域，我只能总结说，他们的动机是真诚的——完全专注于改善病人护理的统一目标。无论如何，他们开创了一个新时代，创造了第一本致力于灌注领域的正式出版物:《体外技术杂志》(Journal of ExtraCorporeal Technology)。
{"title":"The Advancement of Perfusion Sciences","authors":"A. Stammers","doi":"10.1051/ject/20013312","DOIUrl":"https://doi.org/10.1051/ject/20013312","url":null,"abstract":"Thirty-three years ago, a fledgling group of individuals identified the need for a publication devoted to the field extracorporeal circulation. These pioneers were drawn from numerous disciplines that included dialysis technicians, cardiovascular research laboratories, and allied health fields, yet were unified through a common goal: A commitment to grasp a fuller understanding of the intricacies of blood flow outside of the body. They were unencumbered by neither the temptations of finance, nor by ego, since cardiac surgery, with the use of the heart-lung machine, had yet to experience the tremendous growth that soon followed. Having joined the field since that time, I can only summize that their motivations were genuine—focused totally upon the unifying goal of improving patient care. Regardless, they ushered in a new era with the creation of the first formal publication dedicated to the field of perfusion: the Journal of ExtraCorporeal Technology.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133635058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhu De, Wang Wei, Chen Hong, Zhang Wei, Lin Ru, Xiongkai Zhu, Ahznk Zewei, Kang Manli, Xia Qiang
The purpose of this study is to investigate the effectiveness of pinacidil, an opener of ATP-sensitive K+ channels, in protecting myocardium of immature rabbit hearts from ischemic reperfusion injury. Methods: On Langendorff apparatus the hearts underwent 30 minutes of global normothermic ischemia followed by 30 minutes of reperfusion. 52 isolated hearts of 3–4 weeks old immature rabbits were divided into four groups randomly. During ischemia, three different cardioplegic solutions were administered intermittently by infusion every 15 minutes (20–25 ml every time) Group I control (n=13),; Group II: K-H solution with potassium (16 mmol/L) (n=13) ; Group III: K-H solution with potassium (16 mmol/L) and pinacidil (50 m mol/L) (n=13); Group IV: K-H solution with potassium (16 mmol/L), pinacidil(50 m mol/L) and glibenclamide (10 m mol/L) (n=13). The pre and postischemic myocardial function were assessed by the percentage recovery of left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP), both positive and negative peak first derivative of left ventricular pressures(± dp/ptmax), coronary flow(CF), CK, LDH, AST in coronary sinus venous effluent and by myocardial ultrastructural changes. Results: Before myocardial ischemia, there were no significant difference in all above mentioned parameters in four groups. Postischemic recovery of LVDP, LVEDP, ± dp/dtmax, CF, the level of CK, LDH, AST and myocardial ultrastructural changes were better in group III than that in three other groups.
{"title":"Abstracts for Oral and Poster Presentations","authors":"Zhu De, Wang Wei, Chen Hong, Zhang Wei, Lin Ru, Xiongkai Zhu, Ahznk Zewei, Kang Manli, Xia Qiang","doi":"10.1051/ject/200133137","DOIUrl":"https://doi.org/10.1051/ject/200133137","url":null,"abstract":"The purpose of this study is to investigate the effectiveness of pinacidil, an opener of ATP-sensitive K+ channels, in protecting myocardium of immature rabbit hearts from ischemic reperfusion injury. Methods: On Langendorff apparatus the hearts underwent 30 minutes of global normothermic ischemia followed by 30 minutes of reperfusion. 52 isolated hearts of 3–4 weeks old immature rabbits were divided into four groups randomly. During ischemia, three different cardioplegic solutions were administered intermittently by infusion every 15 minutes (20–25 ml every time) Group I control (n=13),; Group II: K-H solution with potassium (16 mmol/L) (n=13) ; Group III: K-H solution with potassium (16 mmol/L) and pinacidil (50 m mol/L) (n=13); Group IV: K-H solution with potassium (16 mmol/L), pinacidil(50 m mol/L) and glibenclamide (10 m mol/L) (n=13). The pre and postischemic myocardial function were assessed by the percentage recovery of left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP), both positive and negative peak first derivative of left ventricular pressures(± dp/ptmax), coronary flow(CF), CK, LDH, AST in coronary sinus venous effluent and by myocardial ultrastructural changes. Results: Before myocardial ischemia, there were no significant difference in all above mentioned parameters in four groups. Postischemic recovery of LVDP, LVEDP, ± dp/dtmax, CF, the level of CK, LDH, AST and myocardial ultrastructural changes were better in group III than that in three other groups.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133995260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiopulmonary Bypass Principles and Practice, 2nd Edition","authors":"G. Gravlee, Richard F. Davis, M. Kurusz, J. Utley","doi":"10.1051/ject/2000324224","DOIUrl":"https://doi.org/10.1051/ject/2000324224","url":null,"abstract":"","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122490509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phyllis Palmer Stark: Editor Extraordinaire of the Journal of Extra-Corporeal Technology","authors":"A. Stammers","doi":"10.1051/ject/2000323118","DOIUrl":"https://doi.org/10.1051/ject/2000323118","url":null,"abstract":"","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125356109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is understood that the biocompatibility of a material depends upon the proteins that bind to its surface. It is this protein layer that interacts directly with components of the coagulation and inflammatory systems. Fibrinogen, capable of platelet binding and activation, is a particularly important protein in determining a material’s biocompatibility. Hydrophobic materials tend to have a greater affinity for fibrinogen, making them less biocompatible than hydrophilic materials. We compared the hydrophobicity of three different heparin-coated polyvinylchloride (PVC) tubing preparations with uncoated PVC tubing. We also determined if there would be a difference in the applied solution; water, an ionic solution (saline), and a protein solution (fresh frozen plasma). Hydrophobicity was quantified with five separate measurements of contact angles of water, saline, and plasma, and droplet spread diameter of water and saline. We found that Duraflo II displayed hydrophobicity similar to that of uncoated PVC tubing (initial contact angles of water were 78.0 ± 1.1 and 79.6 ± 0.6 degrees, respectively). Carmeda and 3M heparin-coated tubings displayed significantly (p < .01) less hydrophobicity (initial contact angles of water were 59.8 ± 2.1 and 39.6 ± 1.9, respectively). Three minutes after initial contact, the 3M heparin coating was the only preparation that remained significantly (p < .01) less hydrophobic than the uncoated PVC. These data suggest that 3M heparin-coated PVC is the most biocompatible of the tubings we examined, followed by Carmeda, Duraflo II, and the untreated PVC tubing.
{"title":"Quantification of Hydrophobicity of Heparin-Treated Polyvinylchloride Tubing","authors":"H. E. Albino, Stuart K. Williams, D. Larson","doi":"10.1051/ject/2000322070","DOIUrl":"https://doi.org/10.1051/ject/2000322070","url":null,"abstract":"It is understood that the biocompatibility of a material depends upon the proteins that bind to its surface. It is this protein layer that interacts directly with components of the coagulation and inflammatory systems. Fibrinogen, capable of platelet binding and activation, is a particularly important protein in determining a material’s biocompatibility. Hydrophobic materials tend to have a greater affinity for fibrinogen, making them less biocompatible than hydrophilic materials. We compared the hydrophobicity of three different heparin-coated polyvinylchloride (PVC) tubing preparations with uncoated PVC tubing. We also determined if there would be a difference in the applied solution; water, an ionic solution (saline), and a protein solution (fresh frozen plasma). Hydrophobicity was quantified with five separate measurements of contact angles of water, saline, and plasma, and droplet spread diameter of water and saline. We found that Duraflo II displayed hydrophobicity similar to that of uncoated PVC tubing (initial contact angles of water were 78.0 ± 1.1 and 79.6 ± 0.6 degrees, respectively). Carmeda and 3M heparin-coated tubings displayed significantly (p < .01) less hydrophobicity (initial contact angles of water were 59.8 ± 2.1 and 39.6 ± 1.9, respectively). Three minutes after initial contact, the 3M heparin coating was the only preparation that remained significantly (p < .01) less hydrophobic than the uncoated PVC. These data suggest that 3M heparin-coated PVC is the most biocompatible of the tubings we examined, followed by Carmeda, Duraflo II, and the untreated PVC tubing.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115178541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report the administration of biologic antithrombin III (AT III) concentrate for the treatment of heparin resistance in 44 patients undergoing cardiopulmonary bypass (CPB). During CPB, the amount of heparin required to maintain an activated clotting time greater than 480 sec was significantly reduced following the administration of AT III concentrate (p = .000). The average increase in the ACT was 176 sec following the administration of AT III concentrate (p = .000). Thirteen of 44 patients did not require any additional heparin for the duration of CPB after AT III therapy. AT III concentrate seemed to be efficacious in the treatment of heparin resistance attributable to presumed AT III deficiency. Moreover, the reduction in heparin requirements following administration of AT III concentrate may reduce postoperative bleeding associated with heparin rebound, protamine requirements, and its associated complications and threat of intravascular coagulation during CPB.
{"title":"The Use of Human Antithrombin III Concentrate for Treatment of Heparin Resistance During Cardiopulmonary Bypass","authors":"M. E. Brown, J. M. Gallagher, J. Armitage","doi":"10.1051/ject/2000322075","DOIUrl":"https://doi.org/10.1051/ject/2000322075","url":null,"abstract":"We report the administration of biologic antithrombin III (AT III) concentrate for the treatment of heparin resistance in 44 patients undergoing cardiopulmonary bypass (CPB). During CPB, the amount of heparin required to maintain an activated clotting time greater than 480 sec was significantly reduced following the administration of AT III concentrate (p = .000). The average increase in the ACT was 176 sec following the administration of AT III concentrate (p = .000). Thirteen of 44 patients did not require any additional heparin for the duration of CPB after AT III therapy. AT III concentrate seemed to be efficacious in the treatment of heparin resistance attributable to presumed AT III deficiency. Moreover, the reduction in heparin requirements following administration of AT III concentrate may reduce postoperative bleeding associated with heparin rebound, protamine requirements, and its associated complications and threat of intravascular coagulation during CPB.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128326045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Defoe, R. Harbaugh, Grant H. Shumaker, Christian P DioDato, N. A. Dame, Mark S. Farrell, C. A. Marrin, L. J. Dacey, J. Sanders, W. Nugent
Modern advances in neurosurgical technique and improvements in cardiopulmonary bypass technology have facilitated a renewed interest in the ligation of giant cerebral aneurysms utilizing deep hypothermia and low-flow conditions. The widespread introduction of biocompatible heparin-bonded bypass circuits presents perfusionists with the opportunity to curtail sharply the need for heparin and protamine in these patients. We briefly discuss the merits of this procedure and describe our clinical experience.
{"title":"Circulatory Support for Repair of Cerebral Aneurysms Using Heparin-Bonded Bypass Circuits and Low-Dose Heparin","authors":"G. Defoe, R. Harbaugh, Grant H. Shumaker, Christian P DioDato, N. A. Dame, Mark S. Farrell, C. A. Marrin, L. J. Dacey, J. Sanders, W. Nugent","doi":"10.1051/ject/2000322079","DOIUrl":"https://doi.org/10.1051/ject/2000322079","url":null,"abstract":"Modern advances in neurosurgical technique and improvements in cardiopulmonary bypass technology have facilitated a renewed interest in the ligation of giant cerebral aneurysms utilizing deep hypothermia and low-flow conditions. The widespread introduction of biocompatible heparin-bonded bypass circuits presents perfusionists with the opportunity to curtail sharply the need for heparin and protamine in these patients. We briefly discuss the merits of this procedure and describe our clinical experience.","PeriodicalId":309024,"journal":{"name":"The Journal of ExtraCorporeal Technology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129229154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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