Çocuk istismarı ve ihmali evrensel bir sorundur ve farkındalığın artırılması, bunu dünya çapında azaltmak için ilk adımdır. Çocuk istismarı vakalarının büyük bir çoğunluğunda boyun, baş ve yüz bölgelerinde yaralar oluşmaktadır. İstismar neticesinde yüz ve çene kemiklerinde kırıklar, dişlerde avülsiyon, kırık veya lüksasyonlar; alveolar ve yanak mukozası, dil, diş eti, dudaklar, damak ya da frenilumlarda yanık ya da delici ve ezici yaralanmalar meydana gelmektedir. Diş hekimlerinin yapacağı değerlendirmeler, istismar ve ihmal vakalarının tanısı ve bildirilmesi noktasında önem taşımaktadır. Bilinçli ve özenli bir intraoral ve ekstraoral bir muayene yapılması ihmal ve istismar kaygısı oluşturan tüm vakalarda gerekir. Literatür taranarak hazırlanan derlemede çocuk istismarı ve ihmali olgularının oral bulguları ve şüpheli vakalarda izlenecek yollar üzerinde durulmaktadır.
{"title":"Evaluation of Child Abuse Findings in Terms of Dentistry","authors":"Deniz Aykam, Ebru HAZAR BODRUMLU","doi":"10.29058/mjwbs.1070016","DOIUrl":"https://doi.org/10.29058/mjwbs.1070016","url":null,"abstract":"Çocuk istismarı ve ihmali evrensel bir sorundur ve farkındalığın artırılması, bunu dünya çapında azaltmak \u0000için ilk adımdır. Çocuk istismarı vakalarının büyük bir çoğunluğunda boyun, baş ve yüz bölgelerinde \u0000yaralar oluşmaktadır. İstismar neticesinde yüz ve çene kemiklerinde kırıklar, dişlerde avülsiyon, kırık \u0000veya lüksasyonlar; alveolar ve yanak mukozası, dil, diş eti, dudaklar, damak ya da frenilumlarda yanık \u0000ya da delici ve ezici yaralanmalar meydana gelmektedir. Diş hekimlerinin yapacağı değerlendirmeler, \u0000istismar ve ihmal vakalarının tanısı ve bildirilmesi noktasında önem taşımaktadır. Bilinçli ve özenli bir \u0000intraoral ve ekstraoral bir muayene yapılması ihmal ve istismar kaygısı oluşturan tüm vakalarda gerekir. \u0000Literatür taranarak hazırlanan derlemede çocuk istismarı ve ihmali olgularının oral bulguları ve şüpheli \u0000vakalarda izlenecek yollar üzerinde durulmaktadır.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127381113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To evaluate the relationship between anxiety levels determined by Beck Anxiety Index (BAI) and Temporomandibular Joint Dysfunction (TMD) prevalence determined by Fonseca Anamnestic Index (FAI) and Class I, Class II and Class III orthodontic malocclusions in young adults who apply with the desire to receive orthodontic treatment. Material and Methods: 120 participants, consisting of young adults aged 14-24, who consecutively applied for the correction of malocclusions, constitute the material of our study. As a result of the clinical examination, individuals were divided into 3 groups as Angle Class I, II and III according to their dental malocclusions. Each group is divided into two subgroups as male and female individuals. As a result, 6 groups were formed with 20 individuals in each group. In addition to routine orthodontic examination, FAI was applied to evaluate the prevalence and severity of TMD, and BAI was applied to determine their anxiety levels. Fischer’s Exact test, Mann-Whitney U test and Kruskal Wallis test were used to evaluate the data. Kendall Tau-b correlation test was used to evaluate the relationship between BAI and FAI. Significance level was accepted as p
{"title":"Evaluation of the Relationship between Anxiety Levels, Temporomandibular Joint Dysfunction Scores and Orthodontic Malocclusion in Individuals who Seeking Orthodontic Treatment","authors":"Kevser Kurt Demirsoy, S. Büyük, Nursu Becet","doi":"10.29058/mjwbs.1114749","DOIUrl":"https://doi.org/10.29058/mjwbs.1114749","url":null,"abstract":"Aim: To evaluate the relationship between anxiety levels determined by Beck Anxiety Index (BAI) and Temporomandibular Joint Dysfunction \u0000(TMD) prevalence determined by Fonseca Anamnestic Index (FAI) and Class I, Class II and Class III orthodontic malocclusions in young \u0000adults who apply with the desire to receive orthodontic treatment. \u0000Material and Methods: 120 participants, consisting of young adults aged 14-24, who consecutively applied for the correction of malocclusions, \u0000constitute the material of our study. As a result of the clinical examination, individuals were divided into 3 groups as Angle Class I, II and \u0000III according to their dental malocclusions. Each group is divided into two subgroups as male and female individuals. As a result, 6 groups \u0000were formed with 20 individuals in each group. In addition to routine orthodontic examination, FAI was applied to evaluate the prevalence \u0000and severity of TMD, and BAI was applied to determine their anxiety levels. Fischer’s Exact test, Mann-Whitney U test and Kruskal Wallis \u0000test were used to evaluate the data. Kendall Tau-b correlation test was used to evaluate the relationship between BAI and FAI. Significance \u0000level was accepted as p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130158871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: İş Sağlığı ve Güvenliği alanında önleyici stratejilerin geliştirilmesi, uygulanması ve başarısı her şeyden önce mevcut durumun çok yönlü ve doğru değerlendirilmesini gerekli kılmaktadır. Bu araştırma ile hem konu ile ilgili literatüre hem de uzun vadede etkili İş Sağlığı ve Güvenliği uygulamalarının geliştirilmesine katkı sağlamak amaçlanmaktadır. Gereç ve Yöntemler: Türkiye’de bir üniversite hastanesinde kolayda örnekleme yöntemiyle yürütülen tanımlayıcı çalışmada, 2017 yılı Mayıs ayı içerisinde anket uygulanarak, hemşire (n=149) ve doktorlardan (n=43) oluşan 192 sağlık profesyoneline ulaşılmıştır. Veri toplamak için katılımcıların demografik özellikleri, son bir yıl içerisinde yaralanma ve enfeksiyon bulaşma riski taşıyan kaza deneyimleri ve İş Sağlığı ve Güvenliği eğitimlerine katılımları ile ilgili soruları içeren bir anket formu kullanılmıştır. Toplanan veriler SPSS Statistics 19 programında analiz edilmiştir. Çalışmanın hipotezleri, %95’lik güven aralığında, p
{"title":"Examining the Occupational Accident Risks and Occupational Health and Safety Trainings of Doctors and Nurses","authors":"Mehpare TATLI YÖNDEM, A. Çakmak","doi":"10.29058/mjwbs.1021934","DOIUrl":"https://doi.org/10.29058/mjwbs.1021934","url":null,"abstract":"Amaç: İş Sağlığı ve Güvenliği alanında önleyici stratejilerin geliştirilmesi, uygulanması ve başarısı her \u0000şeyden önce mevcut durumun çok yönlü ve doğru değerlendirilmesini gerekli kılmaktadır. Bu araştırma \u0000ile hem konu ile ilgili literatüre hem de uzun vadede etkili İş Sağlığı ve Güvenliği uygulamalarının \u0000geliştirilmesine katkı sağlamak amaçlanmaktadır. \u0000Gereç ve Yöntemler: Türkiye’de bir üniversite hastanesinde kolayda örnekleme yöntemiyle \u0000yürütülen tanımlayıcı çalışmada, 2017 yılı Mayıs ayı içerisinde anket uygulanarak, hemşire (n=149) \u0000ve doktorlardan (n=43) oluşan 192 sağlık profesyoneline ulaşılmıştır. Veri toplamak için katılımcıların \u0000demografik özellikleri, son bir yıl içerisinde yaralanma ve enfeksiyon bulaşma riski taşıyan kaza \u0000deneyimleri ve İş Sağlığı ve Güvenliği eğitimlerine katılımları ile ilgili soruları içeren bir anket formu \u0000kullanılmıştır. Toplanan veriler SPSS Statistics 19 programında analiz edilmiştir. Çalışmanın hipotezleri, \u0000%95’lik güven aralığında, p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116165803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To reduce morbidity and mortality in surgical operations to be applied to the craniovertebral junction, it is important to know the anatomical structures in the skull base and the topographical relationship between these structures. Lateral suboccipital craniotomy and occipital condyle resection are among the preferred methods. Surrounding neurovascular structures may be damaged during occipital condyle resection. The aim of study was to develop regression formulas that will determine the precise location of the occipital condyle and estimate the distances to the surrounding anatomical structures, based on the skull morphometry of the person. Material and Methods: The study was carried out on 22 condylus occipitalis (11 skulls) at Harran University, Medical Faculty Anatomy Laboratory. The determined 27 parameters were measured via the Image J program on the skulls’ inferior, anterior, lateral and posterior aspect photographs. Multiple linear regression analysis was performed. Results: To determine the morphometric and topographic features of the occipital condyle, the equations have been developed such as; The occipital condyle length= -2.142 + (0.330 x P15) – (0.468 x P19) – (0.748 x P20) + (0.807 x P21); Adjusted R2= 0.911, Standard Error of the Estimation= 0.938. Conclusion: Considering the difference between the minimum and the maximum values observed in descriptive statistics, the distribution between these values, the different findings in the studies in the literature, there may be erroneous applications in the attempts to be made over the mean values. We believe that the formulas we have developed will be beneficial in personal-specific approaches.
{"title":"Condylus Occipitalis’in Morfometrik-Topografik Özelliklerinin ve Klinik Öneminin Değerlendirilmesi","authors":"Serdar Babacan, Rohat Bayat, Mustafa Deniz","doi":"10.29058/mjwbs.1160776","DOIUrl":"https://doi.org/10.29058/mjwbs.1160776","url":null,"abstract":"Aim: To reduce morbidity and mortality in surgical operations to be applied to the craniovertebral junction, \u0000it is important to know the anatomical structures in the skull base and the topographical relationship \u0000between these structures. Lateral suboccipital craniotomy and occipital condyle resection are among \u0000the preferred methods. Surrounding neurovascular structures may be damaged during occipital condyle \u0000resection. The aim of study was to develop regression formulas that will determine the precise location \u0000of the occipital condyle and estimate the distances to the surrounding anatomical structures, based on \u0000the skull morphometry of the person. \u0000Material and Methods: The study was carried out on 22 condylus occipitalis (11 skulls) at Harran \u0000University, Medical Faculty Anatomy Laboratory. The determined 27 parameters were measured via the \u0000Image J program on the skulls’ inferior, anterior, lateral and posterior aspect photographs. Multiple linear \u0000regression analysis was performed. \u0000Results: To determine the morphometric and topographic features of the occipital condyle, the \u0000equations have been developed such as; The occipital condyle length= -2.142 + (0.330 x P15) – (0.468 \u0000x P19) – (0.748 x P20) + (0.807 x P21); Adjusted R2= 0.911, Standard Error of the Estimation= 0.938. \u0000Conclusion: Considering the difference between the minimum and the maximum values observed in \u0000descriptive statistics, the distribution between these values, the different findings in the studies in the \u0000literature, there may be erroneous applications in the attempts to be made over the mean values. We \u0000believe that the formulas we have developed will be beneficial in personal-specific approaches.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120856952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: In the clinical course of Chronic Obstructive Pulmonary Disease (COPD), exacerbations that are defined as worsening of respiratory symptoms (dyspnoea, cough, sputum production) may occur, which causes poor prognosis and require additional treatments. Cost-effective mortality predictors are valuable for the treatment management of COPD. We aimed to investigate whether serum uric acid (UA) and serum uric acid to creatinine ratio (UCR) are predictors of mortality and hypoxemia in patients with acute exacerbations of COPD (AECOPD). Material and Methods: 105 patients with AECOPD who were hospitalized in a reference chest hospital between January 2014 and December 2018 were evaluated retrospectively in this cross-sectional study. The associations between UA and UCR and long-term mortality, hypoxemia, comorbidity, FEV1 value, and Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (GOLD) stage were analyzed. Results: In the present study including 105 patients with AECOPD (97 males, mean age of 65±9 years), a significant correlation was found between hyperuricemia and mortality (95% CI:1.15-10.72, p=0.027; 95% CI:1.16-4.12, p=0.016, respectively), while no correlation was found between UCR and mortality (p=0.051, p=0.053, respectively). Low UA level was associated with hypoxemia significantly (p=0.022), but no association was observed between UCR and hypoxemia (p=0.094). Conclusion: It appears that UA is more important for predicting long-term mortality in patients with AECOPD than UCR. We suggest that UA can be used as a biomarker of long-term mortality for the identification of high-risk COPD patients that require frequent clinical follow-up and intense treatment management.
{"title":"Kronik Obstrüktif Akciğer Hastalığının Akut Alevlenmesinde Ürik Asit ve Ürik Asitin Kreatinine Oranı Mortalitenin Öngörücüleri midir?","authors":"Hülya Abali, Seda TURAL ÖNÜR, Fatma TOKGÖZ AKYIL, Dila Demir, Sinem Nedime Sökücü, Neslihan Boyraci","doi":"10.29058/mjwbs.1027675","DOIUrl":"https://doi.org/10.29058/mjwbs.1027675","url":null,"abstract":"Aim: In the clinical course of Chronic Obstructive Pulmonary Disease (COPD), exacerbations that \u0000are defined as worsening of respiratory symptoms (dyspnoea, cough, sputum production) may occur, \u0000which causes poor prognosis and require additional treatments. Cost-effective mortality predictors are \u0000valuable for the treatment management of COPD. We aimed to investigate whether serum uric acid \u0000(UA) and serum uric acid to creatinine ratio (UCR) are predictors of mortality and hypoxemia in patients \u0000with acute exacerbations of COPD (AECOPD). \u0000Material and Methods: 105 patients with AECOPD who were hospitalized in a reference chest hospital \u0000between January 2014 and December 2018 were evaluated retrospectively in this cross-sectional study. \u0000The associations between UA and UCR and long-term mortality, hypoxemia, comorbidity, FEV1 value, \u0000and Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary \u0000Disease (GOLD) stage were analyzed. \u0000Results: In the present study including 105 patients with AECOPD (97 males, mean age of 65±9 years), \u0000a significant correlation was found between hyperuricemia and mortality (95% CI:1.15-10.72, p=0.027; \u000095% CI:1.16-4.12, p=0.016, respectively), while no correlation was found between UCR and mortality \u0000(p=0.051, p=0.053, respectively). Low UA level was associated with hypoxemia significantly (p=0.022), \u0000but no association was observed between UCR and hypoxemia (p=0.094). \u0000Conclusion: It appears that UA is more important for predicting long-term mortality in patients with \u0000AECOPD than UCR. We suggest that UA can be used as a biomarker of long-term mortality for the \u0000identification of high-risk COPD patients that require frequent clinical follow-up and intense treatment \u0000management.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131908299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anıl TURHAN ÇAKIR, Çağdaş Baytar, T. Bayraktaroğlu
Amaç: Kanıta dayalı tıp, klinik bakımı optimize etmek için, hekimleri yayınlanmış literatürü anlama ve kullanabilme açısından eğitmeye odaklanmıştır. Kanıta dayalı tıp uygulamaları, hekim adaylarının eğitiminde, eleştirel düşünme ve bilimsel akıl yürütmenin önemini vurgulamak açısından gereklidir. Fakültemizde kanıta dayalı tıp uygulamalarına önem verilmekte ve tıp eğitimi içerisinde yer almaktadır. Bu uygulamanın amacı, öğrencilerin kanıta dayalı tıbbın önemini kavramalarını, bilimsel bir araştırmanın planlanması ve sonuçlandırılması sürecindeki sorumlulukların ve işbirliğinin farkına varmalarını sağlamaktır. Gereç ve Yöntemler: Kanıta dayalı tıp uygulamaları, tıp fakültesi dönem 3 ders programı içinde yer almaktadır. Öğrenciler, eğitim komisyon başkanı önderliğinde sorumlu öğretim üyesi eşliğinde gruplara ayrılır, bir döneme yayılacak şekilde belirlenen tarihlerde gruplar halinde bir araya gelir ve bilimsel bir araştırma planlarlar. Etik kurulu onayı sonrası verilerin toplanması ve değerlendirilmesi gerçekleştirilir, sonuçlandırılan araştırmalar öğrenciler tarafından sunularak tartışılır. Bulgular: 2021-2022 Eğitim ve Öğretim döneminde gerçekleştirilen kanıta dayalı tıp çalışmalarına 215 Dönem 3 öğrencisi ve 15 sorumlu öğretim üyesi katıldı. Çeşitli alanlarda, başta öğrencilerin olmak üzere, bilgi tutum ve davranışların araştırıldığı çalışmalar ile bazı hastalıkların klinik özelliklerinin araştırıldığı toplam 15 farklı çalışma yapıldı. Çalışmaların sonuçları sorumlu öğretim üyesi önderliğinde öğrenciler tarafında tüm tıp fakültesi öğrenci ve öğretim üyelerinin davet edildiği bir oturumda sunuldu ve tartışıldı. Sonuç: 2021-2022 Eğitim ve Öğretim döneminde, tüm dönem 3 öğrencileri, kanıta dayalı tıbbın önemini kavrayarak, sorumlu öğretim üyesi yürütücülüğünde bilimsel bir çalışmanın tüm aşamalarını yürüttüler ve çalışmalarını başarıyla sonlandırıp sundular.
{"title":"Evidence Based Medicine Practice of Zonguldak Bülent Ecevit University Medical Faculty 2021-2022 Education Term Class 3 Student","authors":"Anıl TURHAN ÇAKIR, Çağdaş Baytar, T. Bayraktaroğlu","doi":"10.29058/mjwbs.1150644","DOIUrl":"https://doi.org/10.29058/mjwbs.1150644","url":null,"abstract":"Amaç: Kanıta dayalı tıp, klinik bakımı optimize etmek için, hekimleri yayınlanmış literatürü anlama \u0000ve kullanabilme açısından eğitmeye odaklanmıştır. Kanıta dayalı tıp uygulamaları, hekim adaylarının \u0000eğitiminde, eleştirel düşünme ve bilimsel akıl yürütmenin önemini vurgulamak açısından gereklidir. \u0000Fakültemizde kanıta dayalı tıp uygulamalarına önem verilmekte ve tıp eğitimi içerisinde yer almaktadır. \u0000Bu uygulamanın amacı, öğrencilerin kanıta dayalı tıbbın önemini kavramalarını, bilimsel bir araştırmanın \u0000planlanması ve sonuçlandırılması sürecindeki sorumlulukların ve işbirliğinin farkına varmalarını \u0000sağlamaktır. \u0000Gereç ve Yöntemler: Kanıta dayalı tıp uygulamaları, tıp fakültesi dönem 3 ders programı içinde yer \u0000almaktadır. Öğrenciler, eğitim komisyon başkanı önderliğinde sorumlu öğretim üyesi eşliğinde gruplara \u0000ayrılır, bir döneme yayılacak şekilde belirlenen tarihlerde gruplar halinde bir araya gelir ve bilimsel bir \u0000araştırma planlarlar. Etik kurulu onayı sonrası verilerin toplanması ve değerlendirilmesi gerçekleştirilir, \u0000sonuçlandırılan araştırmalar öğrenciler tarafından sunularak tartışılır. \u0000Bulgular: 2021-2022 Eğitim ve Öğretim döneminde gerçekleştirilen kanıta dayalı tıp çalışmalarına 215 \u0000Dönem 3 öğrencisi ve 15 sorumlu öğretim üyesi katıldı. Çeşitli alanlarda, başta öğrencilerin olmak üzere, \u0000bilgi tutum ve davranışların araştırıldığı çalışmalar ile bazı hastalıkların klinik özelliklerinin araştırıldığı \u0000toplam 15 farklı çalışma yapıldı. Çalışmaların sonuçları sorumlu öğretim üyesi önderliğinde öğrenciler \u0000tarafında tüm tıp fakültesi öğrenci ve öğretim üyelerinin davet edildiği bir oturumda sunuldu ve tartışıldı. \u0000Sonuç: 2021-2022 Eğitim ve Öğretim döneminde, tüm dönem 3 öğrencileri, kanıta dayalı tıbbın önemini \u0000kavrayarak, sorumlu öğretim üyesi yürütücülüğünde bilimsel bir çalışmanın tüm aşamalarını yürüttüler \u0000ve çalışmalarını başarıyla sonlandırıp sundular.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126059089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meryem Ergenc, Hale Sayan Özaçmak, I. Turan, Veysel Haktan Özaçmak
Aim: Chronic cerebral hypoperfusion (CCH) leads to vascular dementia with progressive hippocampal damage and cognitive impairments. CCH also causes a decrease in blood flow in the retina.The aim of this study was to investigate the effects of spironolactone on oxidative stress and glycogen levels in the eye and prefrontal cortex (PFC) tissues in ovariectomized rats with CCH. Material and Methods: 32 female Wistar Albino rats were randomly divided into 4 groups, 8 in each group: 1)Control, 2)KSH, 3) KSH+Spironolactone 25mg/kg 4)KSH+Spironolactone 50mg/kg. The rats underwent bilateral ovariectomy (OVX) at the start of the experiment, a CCH model was created with permanent occlusion of the common carotid arteries (2VO) 5 weeks after OVX. Spironolactone was administered by oral gavage three days before 2VO and once daily for 3 weeks after 2VO. At the end of the experiment, tissue glycogen, reduced glutathione (GSH), malondialdehyde (MDA) and ascorbic acid (AA) levels were measured. Statistical analysis was performed using ANOVA and Bonferroni tests. Results: CCH caused an increase in oxidative stress markers and a decrease in glycogen level in PFC. Similarly, CCH caused a decrease in both glycogen and AA levels in the eye tissue. In the group treated with 25mg/kg spironolactone, the AA and PFC glycogen levels of the eyes decreased, while the MDA levels in the PFC were increased compared to the CCH group(p
{"title":"Effect of Spironolactone on Glycogen and Oxidative Stress Parameters in Prefrontal Cortex and Eye Tissues in Rats in Which Surgical Menopause and Chronic Cerebral Hypoperfusion Performed","authors":"Meryem Ergenc, Hale Sayan Özaçmak, I. Turan, Veysel Haktan Özaçmak","doi":"10.29058/mjwbs.1089000","DOIUrl":"https://doi.org/10.29058/mjwbs.1089000","url":null,"abstract":"Aim: Chronic cerebral hypoperfusion (CCH) leads to vascular dementia with progressive hippocampal damage and cognitive impairments. \u0000CCH also causes a decrease in blood flow in the retina.The aim of this study was to investigate the effects of spironolactone on oxidative \u0000stress and glycogen levels in the eye and prefrontal cortex (PFC) tissues in ovariectomized rats with CCH. \u0000Material and Methods: 32 female Wistar Albino rats were randomly divided into 4 groups, 8 in each group: 1)Control, 2)KSH, 3) \u0000KSH+Spironolactone 25mg/kg 4)KSH+Spironolactone 50mg/kg. The rats underwent bilateral ovariectomy (OVX) at the start of the \u0000experiment, a CCH model was created with permanent occlusion of the common carotid arteries (2VO) 5 weeks after OVX. Spironolactone \u0000was administered by oral gavage three days before 2VO and once daily for 3 weeks after 2VO. At the end of the experiment, tissue glycogen, \u0000reduced glutathione (GSH), malondialdehyde (MDA) and ascorbic acid (AA) levels were measured. Statistical analysis was performed using \u0000ANOVA and Bonferroni tests. \u0000Results: CCH caused an increase in oxidative stress markers and a decrease in glycogen level in PFC. Similarly, CCH caused a decrease \u0000in both glycogen and AA levels in the eye tissue. In the group treated with 25mg/kg spironolactone, the AA and PFC glycogen levels of the \u0000eyes decreased, while the MDA levels in the PFC were increased compared to the CCH group(p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114470838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Avascular necrosis of the femoral head is a condition characterized by limited range of motion, pain, and gait disturbance resulting from insufficient blood flow. We aim to evaluate the relationship between COVID-19 and avascular necrosis. Case: Herein, we present a 63-year-old male patient who developed avascular necrosis of the bilateral femoral head after COVID-19. Conclusion: COVID-19 infection alone and corticosteroids given to treat it can increase the incidence of avascular necrosis of the femoral head. MRI of the hip is highly specific in detecting early stagea vascular necrosis of the femoral head and can reduce patient’s disability and need for surgery.
{"title":"COVID-19 Enfeksiyonu Sonrası Femur Başının Bilateral Avasküler Nekrozu: Bir Olgu Sunumu","authors":"Alper Uysal, Merve ERDEM UYSAL","doi":"10.29058/mjwbs.1054040","DOIUrl":"https://doi.org/10.29058/mjwbs.1054040","url":null,"abstract":"Aim: Avascular necrosis of the femoral head is a condition characterized by limited range of motion, \u0000pain, and gait disturbance resulting from insufficient blood flow. We aim to evaluate the relationship \u0000between COVID-19 and avascular necrosis. \u0000Case: Herein, we present a 63-year-old male patient who developed avascular necrosis of the bilateral \u0000femoral head after COVID-19. \u0000Conclusion: COVID-19 infection alone and corticosteroids given to treat it can increase the incidence \u0000of avascular necrosis of the femoral head. MRI of the hip is highly specific in detecting early stagea \u0000vascular necrosis of the femoral head and can reduce patient’s disability and need for surgery.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133830337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Uzun, E. Caliskan Yildirim, H. Semiz, F. Ekinci, B. Demi̇r, A. Erdoğan, A. Karaoglu
Aim: Despite many new generation treatments, it is known that the prognostic markers used to date in patients with metastatic renal cell carcinoma (mRCC), who have a very poor prognosis, can not accurately determine the prognosis in every patient. Therefore, the search for prognostic biomarkers continues. In this study, it was aimed to investigate the effect of pre-treatment biochemical parameters on oncological outcomes in mRHC patients. Material and Methods: We retrospectively evaluated the clinical, pathological, survival characteristics and factors affecting survival of 90 mRCC patients who were metastatic (stage 4) or local (stage 1-3) at the time of diagnosis in our clinic, who underwent radical nephrectomy and relapsed during follow-up. Descriptive statistical analyzes of patients' demographic, clinicopathological and treatment characteristics were performed. Results: 21.2% of the patients were female and 78.8 % were male. There was no difference in median OS (overall survival) between women and men. The median OS duration was statistically significantly lower in patients with metastasis at the time of diagnosis (p=0.001). While the median OS was 36.2 months in metastatic patients at the time of diagnosis, the median OS was 90.4 months in patients with recurrence at follow-up. As the ratio of alkaline phosphatase/Albumin (ALP/ALB) increased, survival decreased (p=0.038). While the median OS of those with a CRP/ALB ratio of 0.072 (AUC.630 p=0.046 cut off:0.072). Conclusion: It has been determined that the CRP/ALB ratio is a biomarker that determines the prognosis. We recommend immunotherapy in patients who progress after first-linetargettherapy. Today, prognosis has become important especially in the treatment decision of mRCC, and we think that our study will shedlight on the search for new prognostic markers.
{"title":"Examination of Factors Affecting General Survival in Patients with Metastatic Renal Cell Cancer: A Case of Dokuz Eylül University Medical Oncology Clinic","authors":"M. Uzun, E. Caliskan Yildirim, H. Semiz, F. Ekinci, B. Demi̇r, A. Erdoğan, A. Karaoglu","doi":"10.29058/mjwbs.1084889","DOIUrl":"https://doi.org/10.29058/mjwbs.1084889","url":null,"abstract":"Aim: Despite many new generation treatments, it is known that the prognostic markers used to date \u0000in patients with metastatic renal cell carcinoma (mRCC), who have a very poor prognosis, can not accurately determine the prognosis in every patient. Therefore, the search for prognostic biomarkers continues. In this study, it was aimed to \u0000investigate the effect of pre-treatment biochemical parameters on oncological outcomes in mRHC patients. \u0000Material and Methods: We retrospectively evaluated the clinical, pathological, survival characteristics and factors affecting survival of 90 \u0000mRCC patients who were metastatic (stage 4) or local (stage 1-3) at the time of diagnosis in our clinic, who underwent radical nephrectomy \u0000and relapsed during follow-up. Descriptive statistical analyzes of patients' demographic, clinicopathological and treatment characteristics \u0000were performed. \u0000Results: 21.2% of the patients were female and 78.8 % were male. There was no difference in median OS (overall survival) between women \u0000and men. The median OS duration was statistically significantly lower in patients with metastasis at the time of diagnosis (p=0.001). While the \u0000median OS was 36.2 months in metastatic patients at the time of diagnosis, the median OS was 90.4 months in patients with recurrence at \u0000follow-up. As the ratio of alkaline phosphatase/Albumin (ALP/ALB) increased, survival decreased (p=0.038). While the median OS of those \u0000with a CRP/ALB ratio of 0.072 (AUC.630 \u0000p=0.046 cut off:0.072). \u0000Conclusion: It has been determined that the CRP/ALB ratio is a biomarker that determines the prognosis. We recommend immunotherapy \u0000in patients who progress after first-linetargettherapy. Today, prognosis has become important especially in the treatment decision of mRCC, \u0000and we think that our study will shedlight on the search for new prognostic markers.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131403121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayhan Atıgan, D. Kiliç, E. Alataş, Yeliz Arman Karakaya, Ö. Güler
Aim: This study was designed to retrospectively evaluatethe clinical and pathological data of cases diagnosed with Vulvar Intraepithelial Neoplasia (VIN) in ourclinic. Material and Methods: 68 patients diagnosed with VIN at Pamukkale University between January 2016 and June 2020 were analyzed retrospectively. Pathological slides were examined with a microscope. Socio demographic data, biopsy and histopathological data of the cases were obtained. Cervical Papsmear, HPV and cervical biopsy results taken simultaneously to VIN cases were grouped and evaluated Results: Of the 68 patients included in the study, 48 were low grade (vLSIL) and 20 were high grade (vHSIL). The mean age in the vLSIL group was 48,60±16,02; gravida 2,54±1,92; parity 2,02±1,60 while; 44,80±14,71; 2,40±1,81; 1,70±1,49 in the vHSIL group, respectively. In the vHSIL group; lesion area (p=0,008), Ki-67 (p=0,001), p53 (p=0,036), p16 (p=0,034) immunohistochemistry staining were statistically significantly higher. There was no difference in HPV staining (p>0,05). There was no statistically significant difference between the groups in terms of simultaneous cervical Pap-smear, HPV-pcr and cervical biopsy (p>0,05). Conclusion: In our study, in accordance with the literature, immunohistochemical markers were found to be higher in the vHSIL group, as in cervical intraepithelial lesions (CIN) and VIN studies. Although it contains common risk factors with CIN, population-based screening for VIN is not yet available. Therefore, the gold standard procedure for diagnosis in the investigation of suspicious vulvar lesions is biopsy. Multi center advanced studies are needed to create algorithms for the diagnosis and treatment of VIN patients
{"title":"Retrospective Analysis of Clinical and Pathological Data of Vulvar IntraepitheliaI Neoplasia Cases","authors":"Ayhan Atıgan, D. Kiliç, E. Alataş, Yeliz Arman Karakaya, Ö. Güler","doi":"10.29058/mjwbs.1115733","DOIUrl":"https://doi.org/10.29058/mjwbs.1115733","url":null,"abstract":"Aim: This study was designed to retrospectively evaluatethe clinical and pathological data of cases \u0000diagnosed with Vulvar Intraepithelial Neoplasia (VIN) in ourclinic. \u0000Material and Methods: 68 patients diagnosed with VIN at Pamukkale University between January 2016 \u0000and June 2020 were analyzed retrospectively. Pathological slides were examined with a microscope. \u0000Socio demographic data, biopsy and histopathological data of the cases were obtained. Cervical Papsmear, \u0000HPV and cervical biopsy results taken simultaneously to VIN cases were grouped and evaluated Results: Of the 68 patients included in the study, 48 were low grade (vLSIL) and 20 were high grade (vHSIL). The mean age in the vLSIL \u0000group was 48,60±16,02; gravida 2,54±1,92; parity 2,02±1,60 while; 44,80±14,71; 2,40±1,81; 1,70±1,49 in the vHSIL group, respectively. \u0000In the vHSIL group; lesion area (p=0,008), Ki-67 (p=0,001), p53 (p=0,036), p16 (p=0,034) immunohistochemistry staining were statistically \u0000significantly higher. There was no difference in HPV staining (p>0,05). There was no statistically significant difference between the groups in \u0000terms of simultaneous cervical Pap-smear, HPV-pcr and cervical biopsy (p>0,05). \u0000Conclusion: In our study, in accordance with the literature, immunohistochemical markers were found to be higher in the vHSIL group, as \u0000in cervical intraepithelial lesions (CIN) and VIN studies. Although it contains common risk factors with CIN, population-based screening for \u0000VIN is not yet available. Therefore, the gold standard procedure for diagnosis in the investigation of suspicious vulvar lesions is biopsy. Multi \u0000center advanced studies are needed to create algorithms for the diagnosis and treatment of VIN patients","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124132034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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