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2023 International Conference on Intelligent Supercomputing and BioPharma (ISBP)最新文献

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Drug Resistance Testing Using Electrical Impedance Counting Method 电阻抗计数法耐药试验
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061299
Jindai Huang, Dianchen Zhang
Traditional methods for testing drug sensitivity values include broth dilution methods including micro broth dilution and macro broth dilution methods, agar dilution methods, E-test methods and paper diffusion methods[1]. These traditional methods have a common shortcoming, that is, the test often takes a long time to obtain drug sensitivity results, which can lead to missed diagnosis, misdiagnosis and delayed treatment.This paper describes how the electrical impedance counting method was used for the study of drug sensitivity testing and what advantages it has over traditional drug sensitivity testing. The impedance counting method still uses the broth dilution method and the existing parameter MIC (minimum inhibitory concentration)[1], which is the most relied upon parameter to guide the use of antibiotics, as an indicator, with the Coulter principle[2] technique as the underlying principle, and the IT system to collect, process and analyze the data. The MIC values were obtained by calculating the number of bacteria at different doses of antibiotics, analyzing the graphical changes such as growth indices, using software algorithms and referring to the CLSI M100[3] standard to discriminate the drug susceptibility of bacteria. The results show that the electrical impedance counting method will provide us with a more rapid and effective method for drug sensitivity analysis, and can be used in medical institutions and related medical industries for drug sensitivity analysis, which is of great significance for rapid and accurate clinical drug use and new antibiotic research.
传统的药敏值检测方法有肉汤稀释法(包括微肉汤稀释法和宏肉汤稀释法)、琼脂稀释法、e试验法和纸扩散法[1]。这些传统方法都有一个共同的缺点,即检测往往需要很长时间才能获得药敏结果,从而导致漏诊、误诊和延误治疗。本文介绍了电阻抗计数法在药敏试验研究中的应用,以及电阻抗计数法相对于传统药敏试验的优势。阻抗计数法仍然采用肉汤稀释法和现有的MIC (minimum inhibitory concentration,最小抑菌浓度)参数[1]作为指标,这是指导抗生素使用最依赖的参数,以Coulter原理[2]技术为基础原理,利用IT系统对数据进行采集、处理和分析。MIC值是通过计算不同抗生素剂量下的细菌数量,分析其生长指标等图形变化,采用软件算法,参照CLSI M100[3]标准对细菌进行药敏鉴别得到的。结果表明,电阻抗计数法将为我们提供一种更为快速有效的药敏分析方法,可用于医疗机构及相关医疗行业进行药敏分析,对临床快速准确用药及新型抗生素研究具有重要意义。
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引用次数: 0
Box-Behnken Designs for the Optimization of the Ethanol Extraction Process for Chuilian Jianpi Granules 疏连健脾颗粒乙醇提取工艺的Box-Behnken设计优化
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061319
Yingying Wang, Guang-Jiao Zhou, Xiao-Wei Li
Objective: The extraction process of Chuilian Jianpi granules was optimized.Methods: The extraction process of Chuilian Jianpi granules was optimized by box-Behnken response surface method, and the comprehensive score was calculated based on the content of geniposide in the extract and the yield of extract.Results: The optimal extraction process was as follows: add water volume multiple of 10 times, cook twice, cook for 3h each time. Under this condition, the comprehensive score was 96.816. The comprehensive score of the validation test was 99.07(RSD=0.54%, n=3), and the results were basically consistent.Conclusion: The process is stable and feasible, which can provide basis for the preparation of Chuilian Jianpi granules.
目的:优选泻连健脾颗粒的提取工艺。方法:采用box-Behnken响应面法对泻连健脾颗粒的提取工艺进行优化,并根据提取液中京尼平苷的含量和提取液得率进行综合评分。结果:最佳提取工艺为:加水量10倍,煮2次,每次煮3h。在此条件下,综合得分为96.816。验证试验的综合评分为99.07(RSD=0.54%, n=3),结果基本一致。结论:该工艺稳定可行,可为泻连健脾颗粒的制备提供依据。
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引用次数: 0
Semi-supervised Medical Image Segmentation with Low-Confidence Consistency and Class Separation 基于低置信度一致性和类分离的半监督医学图像分割
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061306
Zhimin Gao, Tianyou Yu
Deep learning has achieved a great success in various fields, such as image classification, semantic segmentation and so on. But its excellent performance tends to rely on a large amount of data annotations that are hard to collect, especially in dense prediction tasks, like medical image segmentation. Semi-supervised learning (SSL), as a popular solution, relieves the burden of labeling. However, most of current semi-supervised medical image segmentation methods treat each pixel equally and underestimate the importance of indistinguishable and low-proportion pixels which are drowned in easily distinguishable but high-proportion pixels. We believe that these regions with less attention tend to contain crucial and indispensable information to obtain better segmentation performance. Therefore, we propose a simple but effective method for semi-supervised medical image segmentation task via enforcing low-confidence consistency and applying low-confidence class separation. Concretely, we separate low- and high-confidence pixels via the maximum probability values of model’s predictions and only low-confidence pixels are kept. For these remaining pixels, in the mean teacher framework, consistency is enforced for invariant predictions between student and teacher in the output level, and class separation is applied for promoting representations close to corresponding class prototypes in the feature level. We evaluated the proposed approach on two public datasets of cardiac, achieving a higher performance than the state-of-the-art semi-supervised methods on both datasets.
深度学习在图像分类、语义分割等各个领域都取得了巨大的成功。但其优异的性能往往依赖于大量难以收集的数据注释,特别是在密集的预测任务中,如医学图像分割。半监督学习(SSL)作为一种流行的解决方案,减轻了标注的负担。然而,目前大多数半监督医学图像分割方法对每个像素都一视同仁,低估了难以区分的低比例像素的重要性,这些像素被容易区分的高比例像素所淹没。我们认为,这些较少被关注的区域往往包含了关键和不可或缺的信息,从而获得更好的分割性能。因此,我们提出了一种简单而有效的半监督医学图像分割方法,即增强低置信度一致性和应用低置信度类分离。具体来说,我们通过模型预测的最大概率值来分离低置信度像素和高置信度像素,只保留低置信度像素。对于这些剩余的像素,在平均教师框架中,在输出级别强制一致性来实现学生和教师之间的不变预测,并且在特征级别应用类分离来促进接近相应类原型的表示。我们在两个公开的心脏数据集上评估了所提出的方法,在这两个数据集上都取得了比最先进的半监督方法更高的性能。
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引用次数: 0
Intelligent Compound Selection of Anti-cancer Drugs Based on Multi-Objective Optimization 基于多目标优化的抗癌药物智能复方选择
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061321
Xiaoyan Liu, Zhiwei Xu, Guangwen Liu, Limin Liu
In the compound selection process of anti-cancer drugs, safety properties such as drug activity and pharmacokinetics need to be considered simultaneously. To construct a more complete and precise drug screening mechanism, this paper proposed an intelligent compound selection method for anti-cancer drugs based on multi-objective optimization. The proposed model is executed in the MapReduce environment. Quantitatively analyze the biological activity of the compound, and qualitatively analyze the properties of pharmacokinetics and safety properties (Absorption, Distribution, Metabolism, Excretion, and Toxicity) to build a multi-objective optimization model. Guided by Pareto optimization theory, the set of non-inferior solution values was determined, and the compound combination that satisfies the optimization goal was found by genetic optimization. On this basis, a Monte Carlo hypothesis test was used to determine the equipped range of the compounds. Finally, an example of the compound selection of anti-breast cancer drugs is given, and the experimental evaluation proves that the algorithm can screen compounds limitedly, which provides a basis for anti-cancer drug synthesis.
在抗癌药物的化合物选择过程中,需要同时考虑药物活性和药代动力学等安全性。为了构建更完整、更精确的药物筛选机制,本文提出了一种基于多目标优化的抗癌药物智能化合物选择方法。提出的模型在MapReduce环境中执行。定量分析化合物的生物活性,定性分析其药代动力学性质和安全性(吸收、分布、代谢、排泄、毒性),建立多目标优化模型。在Pareto优化理论指导下,确定非劣解值集,通过遗传优化找到满足优化目标的复合组合。在此基础上,采用蒙特卡罗假设检验确定了化合物的装备范围。最后给出了抗乳腺癌药物的化合物选择实例,实验评价证明该算法能够有限筛选化合物,为抗乳腺癌药物的合成提供依据。
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引用次数: 0
Application of virtual reality technology in post-traumatic stress disorder 虚拟现实技术在创伤后应激障碍中的应用
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061313
Jinxiu Zhang, Xunbing Shen
Post-traumatic stress disorder (PTSD) is a series of long-lasting mental disorders caused by individuals experiencing or witnessing life-threatening events, which are characterized by the presence of three main symptom groups: persistent fear memory, hyperarousal and avoidance, causing severe social disorders and health damage to patients. With the development of computer science and technology, emerging virtual reality technology provides a new means of treatment for common mental illness. Based on the analysis of the pathogenesis of PTSD and the superiority of virtual reality technology, this paper reviews the application of virtual reality technology in the treatment of PTSD in recent years at home and abroad. We hope to bring inspiration for the combination of virtual reality technology with traditional therapy and its innovative application for better diagnosis and treatment of PTSD.
创伤后应激障碍(PTSD)是个体经历或目睹危及生命的事件而引起的一系列长期的精神障碍,其特征是存在三种主要症状组:持续恐惧记忆、过度觉醒和回避,对患者造成严重的社交障碍和健康损害。随着计算机科学技术的发展,新兴的虚拟现实技术为治疗常见的精神疾病提供了新的手段。本文在分析PTSD发病机理和虚拟现实技术优越性的基础上,综述了近年来国内外虚拟现实技术在PTSD治疗中的应用。我们希望为虚拟现实技术与传统疗法的结合及其创新应用带来灵感,从而更好地诊断和治疗创伤后应激障碍。
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引用次数: 1
ISBP 2023 Cover Page ISBP 2023封面页
Pub Date : 2023-01-06 DOI: 10.1109/isbp57705.2023.10061300
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引用次数: 0
High-efficiency drug design research based on virtual high-throughput screening 基于虚拟高通量筛选的高效药物设计研究
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061293
Haonan Zhou
Drug screening is crucial in the entire pharmaceutical chain. There are about 3500W of known structural drug compound molecules in the world. The massive amount of data has led to an enormous screening task for a single protein target. Therefore, how accelerating the speed of high-throughput screening is an urgent problem. We combine the advantages of computer CPU multi-core for parallel optimization of D3DOCKxb to achieve accelerated drug screening.
药物筛选在整个制药链中至关重要。世界上已知的结构药物化合物分子约有3500W。大量的数据导致了对单个蛋白质目标的巨大筛选任务。因此,如何加快高通量筛选的速度是一个亟待解决的问题。我们结合计算机CPU多核的优势,对D3DOCKxb进行并行优化,实现药物加速筛选。
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引用次数: 0
ECG arrhythmias Classification with a Graph Bispectrum method 基于图双谱法的心电心律失常分类
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061314
Yang Shiyilin, Shao Jie, Yang Xin, Chen Xin, Wang Xingxing
Heart disease is leading killers of human beings. Recognizing and categorizing Electrocardiogram (ECG) signals is crucial for early heart and cardiovascular disease prevention. A novel classification approach for ECG Arrhythmias based on Graph Bispectrum (GBispec) is proposed. First, the ECG signal is converted from the time domain to the Graph domain by using Graph Fourier Transform (GFT); Then, referring to the traditional bispectrum algorithm, the GFT results of ECG are converted into GBispec; Then, extract the graph features of Graph Integral Bispectrum (GIB), and use Deep Neural Networks(DNN) to process the GIB results. 4 different types of ECG signals are classified. Experiments results show that proposed method is effective in classification.
心脏病是人类的头号杀手。识别和分类心电图信号对早期心脏和心血管疾病的预防至关重要。提出了一种新的基于图双谱(GBispec)的心电失常分类方法。首先,利用图傅里叶变换(GFT)将心电信号从时域转换到图域;然后,参照传统的双谱算法,将ECG的GFT结果转换为GBispec;然后,提取图积分双谱(GIB)的图特征,并使用深度神经网络(DNN)对GIB结果进行处理。分为4种不同类型的心电信号。实验结果表明,该方法具有较好的分类效果。
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引用次数: 0
Depth-First Uncertain Frequent Itemsets Mining based on Ensembled Conditional Item-Wise Supports 基于集成条件项支持的深度优先不确定频繁项集挖掘
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061307
Wanyong Tian, Fuqiang Li, Yibo Liu, Zichen Wang, Zhang Tao
Uncertain frequent pattern mining is usually challenged by the single probabilistic frequent threshold or the single expected support as the measurements of frequent itemsets. A promising solution based on multiple expected minimum support has been introduced in more recent studies to distinguish the mining values of each item, but the intrinsic combinatorial explosion still limited this strategy to be further improved for more generic scenarios. In this paper, a novel mining scheme for uncertain frequent itemsets is proposed. By ensembling multiple conditional item-wise supports, the problems of information redundancy as well as loss caused by a single probabilistic frequent threshold can be effectively improved. Furthermore, by using a variety of pruning strategies based on the property of sorted downward closure and the concept of least minimum probabilistic frequent threshold, an UFP-ECIS (Uncertain Frequent Pattern Mining with Ensembled Conditional Item-wise Supports) algorithm is also introduced. Substantial experiments have been proved to demonstrate that the proposed mining scheme and algorithm has enhanced the information precision of the uncertain frequent itemsets mining.
不确定频繁模式挖掘通常受到单一概率频繁阈值或单一期望支持度作为频繁项集度量的挑战。在最近的研究中,提出了一种基于多个期望最小支持度的有希望的解决方案来区分每个项目的挖掘值,但固有的组合爆炸仍然限制了该策略在更一般场景下的进一步改进。提出了一种新的不确定频繁项集挖掘方案。通过集成多个条件项支持,可以有效地改善信息冗余和单个概率频繁阈值造成的损失问题。在此基础上,利用基于向下闭合排序特性和最小概率频繁阈值概念的多种剪接策略,提出了一种UFP-ECIS(不确定频繁模式挖掘与集成条件逐项支持)算法。大量实验证明,所提出的挖掘方案和算法提高了不确定频繁项集挖掘的信息精度。
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引用次数: 0
EEG Motion Classification Combining Graph Convolutional Network and Self-attentiion 结合图卷积网络和自注意的脑电运动分类
Pub Date : 2023-01-06 DOI: 10.1109/ISBP57705.2023.10061298
Lingyun Chen, Yi Niu
The study of EEG motor imagery adds a new therapeutic approach for patients with motor disorders, and the key to the problem study is how to improve the classification recognition of EEG motor imagery. The complex characteristics of EEG signals and the existence of multi-channel spatio-temporal properties increase the difficulty of their feature extraction and classification. There are spatial correlations between different channels and temporal correlations between different time series signals, so the selection process of signal features is complicated, resulting in low recognition rate. In this paper, we propose a spatial graph convolutional neural network based on a self-attentive mechanism. For the spatial characteristics of signals with different channels, we extract spatial features by constructing a graph structure and then by information aggregation; for its temporal characteristics, we use time slicing to calculate the importance weights of different time periods in the input signal by using the self-attentive mechanism, and then update the time segments by weighting and summing, so as to minimize the influence of other interfering signals, complete feature extraction and improve the The classification recognition rate is improved. From the experimental results, the recognition rate of this model reaches over 88% in the existing open EEG motion imagery dataset, which has good practicality and applicability.
脑电运动图像的研究为运动障碍患者提供了一种新的治疗途径,而如何提高脑电运动图像的分类识别是问题研究的关键。脑电信号的复杂特性和多通道时空特性的存在增加了其特征提取和分类的难度。不同信道之间存在空间相关性,不同时间序列信号之间存在时间相关性,信号特征的选择过程较为复杂,导致识别率较低。本文提出了一种基于自关注机制的空间图卷积神经网络。针对不同信道信号的空间特征,先构造图结构,再进行信息聚合提取空间特征;针对其时间特征,我们采用时间切片的方法,利用自关注机制计算输入信号中不同时间段的重要权重,然后通过加权和求和对时间段进行更新,从而最大限度地减少其他干扰信号的影响,完成特征提取,提高分类识别率。实验结果表明,该模型在现有开放的脑电运动图像数据集中识别率达到88%以上,具有良好的实用性和适用性。
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引用次数: 0
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2023 International Conference on Intelligent Supercomputing and BioPharma (ISBP)
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