Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/54854.2333
Elizabeth Lalhmangaihzuali Fanai, Zonuntluangi Khiangte, Lalrintluangi Chhakchhuak, G. S. Anusuya, Swati M. Patki, Jenny Lalduhawmi Ralte, Remthangpuii Fanai, Larinawmi Hrahsel
Introduction: The clinical presentation and the difference in the pattern of presentation of Paediatric Coronavirus Disease-2019 (COVID-19) positive cases between the first wave and second wave have not been studied in North Eastern region of India. Aim: To study the socio-demographic factors, clinical presentations and also to compare the pattern of presentation of Paediatric COVID-19 positive cases between the first COVID 19 wave and second COVID-19 wave. Materials and Methods: A retrospective observational study of 85 Paediatric COVID-19 positive cases admitted in Zoram Medical College, Mizoram, India, during the period from July 2020 to June 2021 was conducted. Children of age group <14 years were included in the study. The data like age, sex, type of testing done, possible primary contact, symptoms , treatment given and prognosis were collected from the case sheets in Medical Records Department. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency and proportion for categorical variables. Categorical outcomes were compared between study groups using Chi square test/Fisher's Exact test. Results: Records of total of 85 participants were included in the final analysis. The mean age of the study population was 6.59 years. 40 (52.94%) were male patients. Majority , 46 (54.11%) have contracted the infection from their parents. The most common symptoms reported were fever (36.47%), cough (24.71%) and cold (22.4%). A total of 9.42% had co-morbidity. The mean duration of hospital stay was 10.14±5.2 days. In age group <5 years, (58.33%) were symptomatic when compared with 5 to 10 years (16.67%) and 25% in children >10 years (p-value= <0.001). There was a significant difference in the mean age group admitted in first wave (2.91±2.94 years) versus second wave (11.38±2.91 years) (p-value <0.001). Conclusion: The children less than 5 years were more symptomatic when compared with other age groups. Also we can see a transition in age group being infected and it was greater than 10 years old in the second wave. Hence there is an urgent need to vaccinate the population less than 18 years old.
{"title":"Retrospective Study of COVID-19 Positive Paediatric Patients Admitted in a Tertiary Care Hospital, Mizoram, India","authors":"Elizabeth Lalhmangaihzuali Fanai, Zonuntluangi Khiangte, Lalrintluangi Chhakchhuak, G. S. Anusuya, Swati M. Patki, Jenny Lalduhawmi Ralte, Remthangpuii Fanai, Larinawmi Hrahsel","doi":"10.7860/ijnmr/2022/54854.2333","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/54854.2333","url":null,"abstract":"Introduction: The clinical presentation and the difference in the pattern of presentation of Paediatric Coronavirus Disease-2019 (COVID-19) positive cases between the first wave and second wave have not been studied in North Eastern region of India. Aim: To study the socio-demographic factors, clinical presentations and also to compare the pattern of presentation of Paediatric COVID-19 positive cases between the first COVID 19 wave and second COVID-19 wave. Materials and Methods: A retrospective observational study of 85 Paediatric COVID-19 positive cases admitted in Zoram Medical College, Mizoram, India, during the period from July 2020 to June 2021 was conducted. Children of age group <14 years were included in the study. The data like age, sex, type of testing done, possible primary contact, symptoms , treatment given and prognosis were collected from the case sheets in Medical Records Department. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency and proportion for categorical variables. Categorical outcomes were compared between study groups using Chi square test/Fisher's Exact test. Results: Records of total of 85 participants were included in the final analysis. The mean age of the study population was 6.59 years. 40 (52.94%) were male patients. Majority , 46 (54.11%) have contracted the infection from their parents. The most common symptoms reported were fever (36.47%), cough (24.71%) and cold (22.4%). A total of 9.42% had co-morbidity. The mean duration of hospital stay was 10.14±5.2 days. In age group <5 years, (58.33%) were symptomatic when compared with 5 to 10 years (16.67%) and 25% in children >10 years (p-value= <0.001). There was a significant difference in the mean age group admitted in first wave (2.91±2.94 years) versus second wave (11.38±2.91 years) (p-value <0.001). Conclusion: The children less than 5 years were more symptomatic when compared with other age groups. Also we can see a transition in age group being infected and it was greater than 10 years old in the second wave. Hence there is an urgent need to vaccinate the population less than 18 years old.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/52407.2325
N. Thakur, Narendra Rai
Introduction: Low birth babies account for 10% of neonatal mortality. Survival of these babies depends on gestation, birth weight, presence of associated co-morbidities and quality of neonatal care. Aim: To evaluate predictors of mortality of low birth weight neonates admitted in Special Newborn Care Unit (SNCU) of a district hospital in Lucknow. Materials and Methods: A retrospective analysis of case records were done to assess predictors of mortality of low birth weight babies admitted in SNCU of a district hospital in Lucknow from January 2017 to January 2020 was done. Neonatal variables in the form of gender, place of delivery, birth weight, gestation, mode of delivery, need for resuscitation at birth, respiratory distress, need for oxygen, duration of stay in hospital, neonatal outcome in the form of death, discharge, referral or leave against medical advice was assessed. The association between qualitative variables was assessed using Fisher’s-exact test. Quantitative variables were analysed using unpaired t-test. Results: Out of 2227 babies admitted in SNCU of a district hospital, 47.4% (n=1056) babies were low birth weight. Mean age of admission was 3.32±6.35 hours and mean weight on admission was 1.8±0.46 kg. A 53.41% (n=564) were preterm, 46.31% (n=489) were term and only 3 babies (n=0.28%) were post-term babies. A total of 655 (62%) babies were discharged, 85 (8%) referred and 316 (29%) died. Using univariate Odds Ratio (OR) to calculate the risk for mortality and taking p-value <0.05 statistically significant predictors of mortality were prematurity (p-value=0.001, OR 2.223), extremely low birth weight (<0.001), birth asphyxia (p-value=0.024, OR=1.399), place of delivery p-value=0.036, OR=1.290) and duration of stay in the hospital (p-value <0.001). Conclusion: In the present study, it was seen that gestation less than 28 weeks extremely low birth weight perinatal asphyxia and duration of stay in hospital were the most important predictors of mortality. Timely referral could have saved these babies. Consolidation of the existing infrastructure with better networking among the district and tertiary hospitals is required.
{"title":"A Retrospective Study of Predictors of Mortality in Low Birth Weight Neonates in a District Hospital of Lucknow, India","authors":"N. Thakur, Narendra Rai","doi":"10.7860/ijnmr/2022/52407.2325","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/52407.2325","url":null,"abstract":"Introduction: Low birth babies account for 10% of neonatal mortality. Survival of these babies depends on gestation, birth weight, presence of associated co-morbidities and quality of neonatal care. Aim: To evaluate predictors of mortality of low birth weight neonates admitted in Special Newborn Care Unit (SNCU) of a district hospital in Lucknow. Materials and Methods: A retrospective analysis of case records were done to assess predictors of mortality of low birth weight babies admitted in SNCU of a district hospital in Lucknow from January 2017 to January 2020 was done. Neonatal variables in the form of gender, place of delivery, birth weight, gestation, mode of delivery, need for resuscitation at birth, respiratory distress, need for oxygen, duration of stay in hospital, neonatal outcome in the form of death, discharge, referral or leave against medical advice was assessed. The association between qualitative variables was assessed using Fisher’s-exact test. Quantitative variables were analysed using unpaired t-test. Results: Out of 2227 babies admitted in SNCU of a district hospital, 47.4% (n=1056) babies were low birth weight. Mean age of admission was 3.32±6.35 hours and mean weight on admission was 1.8±0.46 kg. A 53.41% (n=564) were preterm, 46.31% (n=489) were term and only 3 babies (n=0.28%) were post-term babies. A total of 655 (62%) babies were discharged, 85 (8%) referred and 316 (29%) died. Using univariate Odds Ratio (OR) to calculate the risk for mortality and taking p-value <0.05 statistically significant predictors of mortality were prematurity (p-value=0.001, OR 2.223), extremely low birth weight (<0.001), birth asphyxia (p-value=0.024, OR=1.399), place of delivery p-value=0.036, OR=1.290) and duration of stay in the hospital (p-value <0.001). Conclusion: In the present study, it was seen that gestation less than 28 weeks extremely low birth weight perinatal asphyxia and duration of stay in hospital were the most important predictors of mortality. Timely referral could have saved these babies. Consolidation of the existing infrastructure with better networking among the district and tertiary hospitals is required.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/55907.2342
D. Dhole, S. Kolhe, A. Saxena, M. Sharif, Vinaykumar P. Hedaginal
Introduction: Anaemia during pregnancy is highly prevalent especially in developing nations (65-75% in India). The causes are multifactorial, nutritional anaemia being the most common cause. Maternal anaemia is known to have adverse neonatal outcomes, including anthropometric measurements. Aim: To study the correlation between maternal haemoglobin level and neonatal birth weight, length and head circumference. Materials and Methods: It was a prospective observational study carried out at DY Patil University School of Medicine and Hospital, Nerul, Navi Mumbai, Maharashtra, India done over two years between November 2018-November 2020. Maternal history, blood samples and neonatal birth weight, length and head circumference were taken. Results were recorded, and qualitative data was presented using frequency, percentage while quantitative data was presented using descriptive statistics. Further statistical analysis was carried out with the help of tests such as Wilcoxon Mann-whitney U test, Kruskal Walis test and Spearman’s correlation test for association. Results: A total of 550 anaemic mothers fulfilling the inclusion criteria were enrolled in the study. Neonatal birth weight, length and head circumference were negatively affected by the severity of maternal anaemia which was statistically significant. Higher Body Mass Index (BMI), compliance with Iron Folic Acid (IFA) supplementation, adequate interpregnancy interval between pregnancies and adequate calorie intake during pregnancy resulted in significant differences in birth weight and length. Conclusion: Maternal anaemia, malnutrition, irregular IFA supplementation, inadequate spacing and inadequate calorie intake significantly hampers neonatal anthropometry.
{"title":"Effect of Maternal Haemoglobin on Neonatal Anthropometry: A Prospective Observational Study","authors":"D. Dhole, S. Kolhe, A. Saxena, M. Sharif, Vinaykumar P. Hedaginal","doi":"10.7860/ijnmr/2022/55907.2342","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/55907.2342","url":null,"abstract":"Introduction: Anaemia during pregnancy is highly prevalent especially in developing nations (65-75% in India). The causes are multifactorial, nutritional anaemia being the most common cause. Maternal anaemia is known to have adverse neonatal outcomes, including anthropometric measurements. Aim: To study the correlation between maternal haemoglobin level and neonatal birth weight, length and head circumference. Materials and Methods: It was a prospective observational study carried out at DY Patil University School of Medicine and Hospital, Nerul, Navi Mumbai, Maharashtra, India done over two years between November 2018-November 2020. Maternal history, blood samples and neonatal birth weight, length and head circumference were taken. Results were recorded, and qualitative data was presented using frequency, percentage while quantitative data was presented using descriptive statistics. Further statistical analysis was carried out with the help of tests such as Wilcoxon Mann-whitney U test, Kruskal Walis test and Spearman’s correlation test for association. Results: A total of 550 anaemic mothers fulfilling the inclusion criteria were enrolled in the study. Neonatal birth weight, length and head circumference were negatively affected by the severity of maternal anaemia which was statistically significant. Higher Body Mass Index (BMI), compliance with Iron Folic Acid (IFA) supplementation, adequate interpregnancy interval between pregnancies and adequate calorie intake during pregnancy resulted in significant differences in birth weight and length. Conclusion: Maternal anaemia, malnutrition, irregular IFA supplementation, inadequate spacing and inadequate calorie intake significantly hampers neonatal anthropometry.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/51020.2326
K. Nagendra, G. Gopal, S. Rudrappa, D. Karthick
Introduction: Emergency Medical Service (EMS) systems have been well established and designed largely to cater to the needs of the cardiac and trauma related emergencies in adult patients. Paediatric emergencies are different; the benefits and outcomes of paediatric EMS have been assumed but without much evidence. With the emergence of paediatric and neonatal Advanced Life Support (ALS); it is imperative to have data that define the problems encountered in the prehospital care setting and also their outcome. This analysis may also provide insights into any modifications that may be required in the EMS system that exists to transport sick children. Aim: To characterise the paediatric prehospital care with emphasis on demography, presenting symptoms, treatment given, prehospital times, vitals monitoring and interventions done during EMS transport affiliated to Emergency Medical Service Agency. Materials and Methods: This descriptive cross-sectional study was conducted from July 2018 to June 2019 in Cheluvamba Hospital, a tertiary care referral teaching hospital attached to Mysore Medical College and Research Institute, Mysuru, India. The study included 147 children who were provided EMS by the 108 ambulance affiliated to the state/central government. Data pertaining to demography, presenting symptoms, vital sign monitoring, treatment given, various prehospital times, and interventions done during transport was obtained and analysed. Inpatient diagnosis with the duration of hospital stay and outcome in these childrens were also described. Results: Among the 147 children included; 3 were brought dead, hence the studied population comprised of 144 children. Amongst them, 42 were neonates and the remaining 102 belonged to the general paediatric population (older children). Overall, 61.8% were males and 57.64% hailed from a rural background. Mean ‘on- scene’ time was 12.12±2.34 minutes and 5.50±5.01 minutes, and ‘transport time’ was 33.79±16.78 minutes, and 26.11±14.2 minutes for neonates and older children, respectively. Respiratory distress was the most common presenting symptom. The mean Heart Rate (HR, beats/min), Respiratory Rate (RR, cycles/min) and temperature (°C) in neonates was 129.86±27.91, 59.90±15.40 and 36.14±0.84 whereas in older children it was 112.81±28.39, 34.87±14.86, and 37.40±0.96, respectively. Mean systolic blood pressure (SBP mmHg) in children aged more than 10 years was 116.67±8.61. Of the 39 children aged more than 6 years, 36 (92.30%) had a Glasgow Coma Scale (GCS) between 13-15. The most common intervention done was administering oxygen in 84.02% (121/144) of children; 34.02% (49/144) of children were unstable at admission; 127 (88.2%) were discharged; remaining 17 (11.8%) succumbed to their illness. On- scene time of more than 15 minutes, transport time of more than 30 minutes and factors such as hypoxia, respiratory failure and shock at admission were significantly associated with mortality (p<0.001). Conclusion: Majority o
{"title":"Characteristics of Paediatric Patients Transported by Emergency Care Personnel in a Government Tertiary Care Centre, Mysuru, India: A Cross-sectional Study","authors":"K. Nagendra, G. Gopal, S. Rudrappa, D. Karthick","doi":"10.7860/ijnmr/2022/51020.2326","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/51020.2326","url":null,"abstract":"Introduction: Emergency Medical Service (EMS) systems have been well established and designed largely to cater to the needs of the cardiac and trauma related emergencies in adult patients. Paediatric emergencies are different; the benefits and outcomes of paediatric EMS have been assumed but without much evidence. With the emergence of paediatric and neonatal Advanced Life Support (ALS); it is imperative to have data that define the problems encountered in the prehospital care setting and also their outcome. This analysis may also provide insights into any modifications that may be required in the EMS system that exists to transport sick children. Aim: To characterise the paediatric prehospital care with emphasis on demography, presenting symptoms, treatment given, prehospital times, vitals monitoring and interventions done during EMS transport affiliated to Emergency Medical Service Agency. Materials and Methods: This descriptive cross-sectional study was conducted from July 2018 to June 2019 in Cheluvamba Hospital, a tertiary care referral teaching hospital attached to Mysore Medical College and Research Institute, Mysuru, India. The study included 147 children who were provided EMS by the 108 ambulance affiliated to the state/central government. Data pertaining to demography, presenting symptoms, vital sign monitoring, treatment given, various prehospital times, and interventions done during transport was obtained and analysed. Inpatient diagnosis with the duration of hospital stay and outcome in these childrens were also described. Results: Among the 147 children included; 3 were brought dead, hence the studied population comprised of 144 children. Amongst them, 42 were neonates and the remaining 102 belonged to the general paediatric population (older children). Overall, 61.8% were males and 57.64% hailed from a rural background. Mean ‘on- scene’ time was 12.12±2.34 minutes and 5.50±5.01 minutes, and ‘transport time’ was 33.79±16.78 minutes, and 26.11±14.2 minutes for neonates and older children, respectively. Respiratory distress was the most common presenting symptom. The mean Heart Rate (HR, beats/min), Respiratory Rate (RR, cycles/min) and temperature (°C) in neonates was 129.86±27.91, 59.90±15.40 and 36.14±0.84 whereas in older children it was 112.81±28.39, 34.87±14.86, and 37.40±0.96, respectively. Mean systolic blood pressure (SBP mmHg) in children aged more than 10 years was 116.67±8.61. Of the 39 children aged more than 6 years, 36 (92.30%) had a Glasgow Coma Scale (GCS) between 13-15. The most common intervention done was administering oxygen in 84.02% (121/144) of children; 34.02% (49/144) of children were unstable at admission; 127 (88.2%) were discharged; remaining 17 (11.8%) succumbed to their illness. On- scene time of more than 15 minutes, transport time of more than 30 minutes and factors such as hypoxia, respiratory failure and shock at admission were significantly associated with mortality (p<0.001). Conclusion: Majority o","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/52320.2328
P. Jose, Nishanth Rajan, Sudiksha Prabhakar, P. Kommu, L. Krishnan
Introduction: When mother’s milk is not available, Infant Milk Substitutes (IMS) must be supplemented with medical advice. Human milk can be digested easily because of the whey protein present in it and which is less in other animal milk. Considering this fact the manufacturers have attempted to make IMS as close to breast milk. Aim: To compare the composition of different IMS with breast milk, and with international guidelines given by European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Materials and Methods: A cross-sectional study was performed between April to May 2020, at a tertiary centre in Puducherry, India. Total 11 whey protein containing IMS brands that were commercially available in the Indian market for children aged up to six months were included in the study. The IMS for preterm babies and those without whey protein like hydrolysed milk, IMS with soya bean extract were excluded from the study. The details of IMS was collected and compared. The composition of the IMS was taken from the information provided by the manufacturer. The data was entered in Microsoft excel and was analysed using statistical software Statistical Package for the Social Sciences (SPSS) version 20.0. Results: With respect to calories, protein, fats and vitamins all IMS met the requirements. Nucleotide content exceeded in 18.1%. Sialic acid was added in 9% IMS. Iron content is more than the ESPGHAN requirement in 9% IMS. Conclusion: All the IMS were almost within the range advised by ESPGHAN. The children who fail to gain adequate weight can be given the brands with more calories. Babies with features of iron deficiency, can be given Brand VIII. For parents who cannot afford to buy the IMS with smart nutrients, they can choose the basic IMS which are of low cost, but meets the requirements.
当没有母乳时，婴儿代用品(IMS)必须补充医疗建议。由于乳清蛋白的存在，人乳很容易被消化，而乳清蛋白在其他动物奶中较少。考虑到这一事实，制造商试图使IMS接近母乳。目的:比较不同IMS与母乳的组成，并与欧洲儿科胃肠病学、肝病学和营养学会(ESPGHAN)给出的国际指南进行比较。材料和方法:一项横断面研究于2020年4月至5月在印度普杜切里的一个高等教育中心进行。在印度市场上为6个月以下儿童提供的含有IMS品牌乳清蛋白的总共11种乳清蛋白被纳入研究。早产儿的IMS和那些没有乳清蛋白的人，如水解牛奶，IMS与大豆提取物被排除在研究之外。收集并比较了IMS的详细信息。IMS的成分取自制造商提供的信息。数据在Microsoft excel中输入，并使用统计软件statistical Package for The Social Sciences (SPSS) 20.0进行分析。结果:IMS的热量、蛋白质、脂肪和维生素均满足要求。核苷酸含量超标18.1%。在9% IMS中加入唾液酸。在9%的IMS中，铁含量超过了ESPGHAN要求。结论:所有IMS均在ESPGHAN建议范围内。那些体重没有达到标准的孩子可以选择含有更多卡路里的品牌。缺铁的宝宝，可以给VIII牌。对于买不起智能营养IMS的家长，可以选择价格较低但符合要求的基本款IMS。
{"title":"Comparison of Various Infant Milk Substitutes with the Guidelines by European Society of Paediatric Gastroenterology, Hepatology and Nutrition: A Cross-sectional Study","authors":"P. Jose, Nishanth Rajan, Sudiksha Prabhakar, P. Kommu, L. Krishnan","doi":"10.7860/ijnmr/2022/52320.2328","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/52320.2328","url":null,"abstract":"Introduction: When mother’s milk is not available, Infant Milk Substitutes (IMS) must be supplemented with medical advice. Human milk can be digested easily because of the whey protein present in it and which is less in other animal milk. Considering this fact the manufacturers have attempted to make IMS as close to breast milk. Aim: To compare the composition of different IMS with breast milk, and with international guidelines given by European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Materials and Methods: A cross-sectional study was performed between April to May 2020, at a tertiary centre in Puducherry, India. Total 11 whey protein containing IMS brands that were commercially available in the Indian market for children aged up to six months were included in the study. The IMS for preterm babies and those without whey protein like hydrolysed milk, IMS with soya bean extract were excluded from the study. The details of IMS was collected and compared. The composition of the IMS was taken from the information provided by the manufacturer. The data was entered in Microsoft excel and was analysed using statistical software Statistical Package for the Social Sciences (SPSS) version 20.0. Results: With respect to calories, protein, fats and vitamins all IMS met the requirements. Nucleotide content exceeded in 18.1%. Sialic acid was added in 9% IMS. Iron content is more than the ESPGHAN requirement in 9% IMS. Conclusion: All the IMS were almost within the range advised by ESPGHAN. The children who fail to gain adequate weight can be given the brands with more calories. Babies with features of iron deficiency, can be given Brand VIII. For parents who cannot afford to buy the IMS with smart nutrients, they can choose the basic IMS which are of low cost, but meets the requirements.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/55789.2347
Ajay S Shandilya, A. Narayan, Hari Krishna, .. Ramya
Congenital Lobar Emphysema (CLE) is a rare congenital disorder causing overinflation of a lobe or lobes of the lung. The left upper lobe is most commonly involved. Surgery is the preferred treatment in cases of CLE, with the patients recovering well after surgery, even with excision of more than one lobe. Here authors report a case of 2-week-old female infant with worsening respiratory distress that did not resolve despite supplemental oxygen and non-invasive ventilatory support and was subsequently diagnosed with Congenital Lobar Emphysema (CLE). The pathology in CLE is the overinflation of the affected lobes and consequent collapse of the normal lobes, leading to hypoxia and reduced gas exchange. The emphysematous lobe causes the mediastinum to shift to the other side, and severe cases may have a haemodynamic compromise. Anaesthesia in such infants is a precarious proposition. The infants may also have other congenital abnormalities. Furthermore, the over distended lobe will cause several problems affecting the infant’s cardiorespiratory physiology. Hence, the preanaesthetic evaluation, anaesthesia plan and execution should be meticulously planned.
{"title":"Anaesthetic Management of Congenital Lobar Emphysema- A Case Report","authors":"Ajay S Shandilya, A. Narayan, Hari Krishna, .. Ramya","doi":"10.7860/ijnmr/2022/55789.2347","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/55789.2347","url":null,"abstract":"Congenital Lobar Emphysema (CLE) is a rare congenital disorder causing overinflation of a lobe or lobes of the lung. The left upper lobe is most commonly involved. Surgery is the preferred treatment in cases of CLE, with the patients recovering well after surgery, even with excision of more than one lobe. Here authors report a case of 2-week-old female infant with worsening respiratory distress that did not resolve despite supplemental oxygen and non-invasive ventilatory support and was subsequently diagnosed with Congenital Lobar Emphysema (CLE). The pathology in CLE is the overinflation of the affected lobes and consequent collapse of the normal lobes, leading to hypoxia and reduced gas exchange. The emphysematous lobe causes the mediastinum to shift to the other side, and severe cases may have a haemodynamic compromise. Anaesthesia in such infants is a precarious proposition. The infants may also have other congenital abnormalities. Furthermore, the over distended lobe will cause several problems affecting the infant’s cardiorespiratory physiology. Hence, the preanaesthetic evaluation, anaesthesia plan and execution should be meticulously planned.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/54951.2335
Vishwanath L. Machakanur, N. Nayak, Naresh T Pavaskar, Malatesh Undi, A. Rachana
Introduction: Hyperlipidemia and its complications are common health issues in the current era with multifactorial in origin. Foetal malnutrition results in neuroendocrine, pancreatic, and adipose tissue dysfunction, ultimately increasing food intake and decreasing energy utilisation. It leads to an increase in adiposity and insulin resistance and ultimately increase adult diseases in later life. Aim: To compare the lipid profiles of Small for Gestational Age (SGA) and Appropriate for Gestational Age (AGA) babies. Materials and Methods: This case-control study was conducted in the Department of Paediatrics, Obstetrics and Gynaecology of Karwar Institute of Medical Sciences, Karwar, Karnataka, India over a period from December 2020 to March 2021. A total of 133 deliveries were recruited randomly and babies were divided into cases including those small for gestational age and controls including those appropriate for gestational age. Data was analysed and described using descriptive (mean, standard deviation, and range) and inferential statistics (Students’ t-test). Results: There were 99 Appropriate for Gestational Age (AGA) and 34 small for Gestational Age (SGA) babies studied. This study found that SGA-babies had statistically significantly lower gestational age (37.69±2.45 weeks) at birth compared to AGA-babies (Mean 38.55±1.11 weeks) t=-2.351 p=0.022. The mean Total Cholesterol (TC) level (63.62±40.48 mg/dL) was higher in SGA-babies compared to AGA-babies (48.69±2.29 mg/dL) and this difference was statistically significant (p-value=0.007). The mean High Density Lipoprotein (HDL) levels of SGA and AGA babies were comparable with no statistical significance (21.82±13.26mg/ dL of SGA; 21.49±14.64mg/dL of AGA; p-value 0.907). The mean Very Low Density Lipoprotein (VLDL) level (17.11±25.35 mg/dL) was higher in SGA-babies compared to AGA-babies (9.47±9.35 mg/dL) and this difference was statistically significant (p-value=0.012). Conclusion: Levels of all lipids were found to be higher in SGA- babies than in AGA-babies.
{"title":"Comparison of Lipid Profiles from Cord Blood of Appropriate and Small for Gestational Age Babies in a Tertiary Care Hospital: A Case-control Study","authors":"Vishwanath L. Machakanur, N. Nayak, Naresh T Pavaskar, Malatesh Undi, A. Rachana","doi":"10.7860/ijnmr/2022/54951.2335","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/54951.2335","url":null,"abstract":"Introduction: Hyperlipidemia and its complications are common health issues in the current era with multifactorial in origin. Foetal malnutrition results in neuroendocrine, pancreatic, and adipose tissue dysfunction, ultimately increasing food intake and decreasing energy utilisation. It leads to an increase in adiposity and insulin resistance and ultimately increase adult diseases in later life. Aim: To compare the lipid profiles of Small for Gestational Age (SGA) and Appropriate for Gestational Age (AGA) babies. Materials and Methods: This case-control study was conducted in the Department of Paediatrics, Obstetrics and Gynaecology of Karwar Institute of Medical Sciences, Karwar, Karnataka, India over a period from December 2020 to March 2021. A total of 133 deliveries were recruited randomly and babies were divided into cases including those small for gestational age and controls including those appropriate for gestational age. Data was analysed and described using descriptive (mean, standard deviation, and range) and inferential statistics (Students’ t-test). Results: There were 99 Appropriate for Gestational Age (AGA) and 34 small for Gestational Age (SGA) babies studied. This study found that SGA-babies had statistically significantly lower gestational age (37.69±2.45 weeks) at birth compared to AGA-babies (Mean 38.55±1.11 weeks) t=-2.351 p=0.022. The mean Total Cholesterol (TC) level (63.62±40.48 mg/dL) was higher in SGA-babies compared to AGA-babies (48.69±2.29 mg/dL) and this difference was statistically significant (p-value=0.007). The mean High Density Lipoprotein (HDL) levels of SGA and AGA babies were comparable with no statistical significance (21.82±13.26mg/ dL of SGA; 21.49±14.64mg/dL of AGA; p-value 0.907). The mean Very Low Density Lipoprotein (VLDL) level (17.11±25.35 mg/dL) was higher in SGA-babies compared to AGA-babies (9.47±9.35 mg/dL) and this difference was statistically significant (p-value=0.012). Conclusion: Levels of all lipids were found to be higher in SGA- babies than in AGA-babies.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/54974.2352
S. Satpathy, Manas R Upadhyay, R. Upadhyay
Introduction: With better healthcare facilities, despite an increase in neonatal survivor rates, the outcomes in the survivors still remains uknown to a great extent. In overburdened centres following an early discharge policy, a structured follow-up plan to evaluate growth, development and problems faced by the high-risk babies is essential. Aim: To assess the growth, development at 52 and 64 weeks Post Menstrual Age (PMA) and association of postnatal growth failure with developmental outcome in Low Birth Weight (LBW) and Very Low Birth Weight (VLBW) babies. Materials and Methods: This was a prospective cohort study carried out amongst the newborn babies discharged from a tertiary care hospital, Sriram Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India. within 2 months period and followed-up till 64 weeks PMA. Out of 189 newborns discharged during study period, 168 met the inclusion criteria and only 114 babies could complete the follow-up till 64 weeks postmenstrual. The weight, length and head circumference were documented at discharge, 44, 52 and 64 weeks PMA and compared using INTERGROWTH 21st postnatal standards. Denver Developmental Screening Test was used for developmental screening at 52 and 64 week PMA. Descriptive analysis was performed using Statistical Package for Social Sciences (SPSS) version 20.0 and categorical data was compared using Chi-square test in trend using Epi Info software. Results: Out of 114 patients, 51 (44.7%) were females and 63 (55.3%) were males. At birth, 72 (63.16%) of study population was below 10th centile which increased to 77 (67.54%) at 44 weeks PMA. By 64 weeks PMA, 62 (54.39%) infants were showing catch up. Out of total, 18 (15.79%) showed delayed developmental milestones. 11 out of 18 (61.11%) babies were with delayed development, i.e., below 3rd centile of weight for age showing that at lower postnatal weight odds of patients having developmental delay were increased. Conclusion: Postnatal growth pattern of the study population was along the lower centiles of INTERGROWTH 21st chart. Incidence of developmental delay was higher in babies with postnatal growth failure.
{"title":"Short Term Assessment of Growth and Neurodevelopmental Outcome in Low Birth Weight and Very Low Birth Weight Newborns Discharged from A Tertiary Care Centre-A Cohort Study","authors":"S. Satpathy, Manas R Upadhyay, R. Upadhyay","doi":"10.7860/ijnmr/2022/54974.2352","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/54974.2352","url":null,"abstract":"Introduction: With better healthcare facilities, despite an increase in neonatal survivor rates, the outcomes in the survivors still remains uknown to a great extent. In overburdened centres following an early discharge policy, a structured follow-up plan to evaluate growth, development and problems faced by the high-risk babies is essential. Aim: To assess the growth, development at 52 and 64 weeks Post Menstrual Age (PMA) and association of postnatal growth failure with developmental outcome in Low Birth Weight (LBW) and Very Low Birth Weight (VLBW) babies. Materials and Methods: This was a prospective cohort study carried out amongst the newborn babies discharged from a tertiary care hospital, Sriram Chandra Bhanja Medical College and Hospital, Cuttack, Odisha, India. within 2 months period and followed-up till 64 weeks PMA. Out of 189 newborns discharged during study period, 168 met the inclusion criteria and only 114 babies could complete the follow-up till 64 weeks postmenstrual. The weight, length and head circumference were documented at discharge, 44, 52 and 64 weeks PMA and compared using INTERGROWTH 21st postnatal standards. Denver Developmental Screening Test was used for developmental screening at 52 and 64 week PMA. Descriptive analysis was performed using Statistical Package for Social Sciences (SPSS) version 20.0 and categorical data was compared using Chi-square test in trend using Epi Info software. Results: Out of 114 patients, 51 (44.7%) were females and 63 (55.3%) were males. At birth, 72 (63.16%) of study population was below 10th centile which increased to 77 (67.54%) at 44 weeks PMA. By 64 weeks PMA, 62 (54.39%) infants were showing catch up. Out of total, 18 (15.79%) showed delayed developmental milestones. 11 out of 18 (61.11%) babies were with delayed development, i.e., below 3rd centile of weight for age showing that at lower postnatal weight odds of patients having developmental delay were increased. Conclusion: Postnatal growth pattern of the study population was along the lower centiles of INTERGROWTH 21st chart. Incidence of developmental delay was higher in babies with postnatal growth failure.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/55097.2338
C. Tom, S. Joseph, Bindusha Sasidharan, V. Anand, A. Santhoshkumar
Introduction: Hypoglycaemia is common in babies at risk. Without early detection, timely diagnosis and treatment, hypoglycaemia can cause disastrous consequences on neurological and developmental outcomes. Therefore, continuous monitoring of blood glucose levels in babies at risk should be done to reduce its impact. Aim: To describe the clinical profile and sequential blood sugar levels in the first four postnatal days in at-risk neonates and to identify the risk group of neonates with recurrent hypoglycaemia. Materials and Methods: This was a longitudinal study done in the Neonatal Intensive Care Unit (NICU) and Special Newborn Care Unit (SNCU) of a tertiary care teaching institute; Sri Avittam Thirunal Hospital (SATH), Government Medical College, Thiruvananthapuram, Kerala, India, from October 2017 to October 2018. Neonates admitted with risk factors for hypoglycaemia according to ‘National Neonatology Forum’ clinical guidelines with low capillary blood sugar (<40 mg/dL) within the first two to four hours of life were included in the study. These neonates were followed-up clinically till fourth postnatal day with glucose monitoring. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software version 22. Categorical variables were expressed as proportions and compared using the Chi-square test. A p-value <0.05 was considered statistically significant. Results: A total of 368 ‘at risk’neonates had hypoglycaemia at admission (2 to 4 hours) and of these 200 (54.3%) developed recurrent hypoglycaemia. Out of the neonates with recurrent hypoglycaemia, 150 (75%) were preterm and 50 (25%) were term. The preterm Small for Gestational Age (SGA) had a higher chance of developing recurrent hypoglycaemia than preterm Appropriate for Gestational Age (AGA) and Large for Gestational Age (LGA) (p-value=0.0256). Although, 102 (40.2%) preterm had asymptomatic hypoglycaemia, 90 (78.9%) term neonates showed symptoms of hypoglycaemia. The major clinical manifestation was jitteriness in those with a single episode 31 (18.45%) and lethargy/poor activity in those with more than one episode 66 (33%). The blood glucose levels less than 25 mg/dL at admission was significantly associated with the occurrence of a repeat episode of hypoglycaemia (p-value=0.028). Conclusion: Blood glucose monitoring in neonates with risk factors is mandatory as 54.3% of neonates developed recurrent hypoglycaemia. Of these, preterm SGA had a high chance of developing recurrent hypoglycaemia. The variable presentations in neonatal hypoglycaemia indicates the need for detailed and thorough clinical examination with glucose monitoring in these at-risk neonates. Initial blood glucose level less than 25 mg/dL was significantly associated with recurrent hypoglycaemia.
{"title":"Clinical Profile of Hypoglycaemia in Neonates at Risk in a Tertiary Care Teaching Institute in Southern India: A Longitudinal Study","authors":"C. Tom, S. Joseph, Bindusha Sasidharan, V. Anand, A. Santhoshkumar","doi":"10.7860/ijnmr/2022/55097.2338","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/55097.2338","url":null,"abstract":"Introduction: Hypoglycaemia is common in babies at risk. Without early detection, timely diagnosis and treatment, hypoglycaemia can cause disastrous consequences on neurological and developmental outcomes. Therefore, continuous monitoring of blood glucose levels in babies at risk should be done to reduce its impact. Aim: To describe the clinical profile and sequential blood sugar levels in the first four postnatal days in at-risk neonates and to identify the risk group of neonates with recurrent hypoglycaemia. Materials and Methods: This was a longitudinal study done in the Neonatal Intensive Care Unit (NICU) and Special Newborn Care Unit (SNCU) of a tertiary care teaching institute; Sri Avittam Thirunal Hospital (SATH), Government Medical College, Thiruvananthapuram, Kerala, India, from October 2017 to October 2018. Neonates admitted with risk factors for hypoglycaemia according to ‘National Neonatology Forum’ clinical guidelines with low capillary blood sugar (<40 mg/dL) within the first two to four hours of life were included in the study. These neonates were followed-up clinically till fourth postnatal day with glucose monitoring. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software version 22. Categorical variables were expressed as proportions and compared using the Chi-square test. A p-value <0.05 was considered statistically significant. Results: A total of 368 ‘at risk’neonates had hypoglycaemia at admission (2 to 4 hours) and of these 200 (54.3%) developed recurrent hypoglycaemia. Out of the neonates with recurrent hypoglycaemia, 150 (75%) were preterm and 50 (25%) were term. The preterm Small for Gestational Age (SGA) had a higher chance of developing recurrent hypoglycaemia than preterm Appropriate for Gestational Age (AGA) and Large for Gestational Age (LGA) (p-value=0.0256). Although, 102 (40.2%) preterm had asymptomatic hypoglycaemia, 90 (78.9%) term neonates showed symptoms of hypoglycaemia. The major clinical manifestation was jitteriness in those with a single episode 31 (18.45%) and lethargy/poor activity in those with more than one episode 66 (33%). The blood glucose levels less than 25 mg/dL at admission was significantly associated with the occurrence of a repeat episode of hypoglycaemia (p-value=0.028). Conclusion: Blood glucose monitoring in neonates with risk factors is mandatory as 54.3% of neonates developed recurrent hypoglycaemia. Of these, preterm SGA had a high chance of developing recurrent hypoglycaemia. The variable presentations in neonatal hypoglycaemia indicates the need for detailed and thorough clinical examination with glucose monitoring in these at-risk neonates. Initial blood glucose level less than 25 mg/dL was significantly associated with recurrent hypoglycaemia.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.7860/ijnmr/2022/58516.2364
P. Bhadane, Ravi Sonawane
Introduction: Prenatal diagnosis is important in outcome of various congenital anomalies in recent times especially in congenital heart diseases. This study would help in recognising the importance of prenatal diagnosis and in understanding the management of newborns with congenital heart diseases. Aim: To evaluate the impact of prenatal diagnosis on the management and prognosis of infants with congenital heart disease. Materials and Methods: This retrospective study was conducted in Department of Paediatrics at Dr. Vasantrao Pawar Medical College, Nashik, Maharshtra, India, from January 2018 to January 2021. The study was performed on newborns who were diagnosed with Congenital Heart Diseases (CHD) during hospitalisation, in an inborn and outborn unit of Neonatal Intensive Care Unit (NICU). The data recorded for requirement of inotropes, ventilation, arterial blood gas analysis and outcome in the form of survival. The babies were classified into Prenatal ECHO (PNE) group and No Prenatal ECHO Available (NPEA) group, based on availability of prenatal Echocardiogram (ECHO) diagnostic report. CHDs were categorised into critical/major and minor. For the comparison of quantitative variables, Unpaired t-test/Mann- Whitney test was used. For the comparison of qualitative variable, Fisher’s-exact test/Chi-square test was used, as necessary. Results: There were 5000 admissions in the inborn and outborn neonatal unit during the study period, of which 159 cases had a diagnosis of CHDs. The PNE group consisted of 61 neonates who had been diagnosed with CHD and the NPEA group consisted of 67 neonates who were not antenatally diagnosed to have CHD. Ionotropic support needed for PNE group (4.5%) was comparatively lesser than NPEA group (14.3%). Need for ventilation was reduced in PNE group (4.5%) as compared to NPEA group (14.3%). Mean for serum lactate and serum bicarbonate was 3.49±2.58 and 16.24±4.31 in PNE group, whereas, it was 5.08±2.79 and 15.12±4.13 in NPEA group on admission in NICU. In management of critical CHDs, 2/31 (6.5%) babies died in PNE group compared to 11/37 (29.7%) in NPEA group (p-value=0.09). Conclusion: Antenatal diagnosis helps in meticulous management of neonates with congenital heart diseases in terms of fewer requirement of inotropes, need of ventilation and improved management. There was no significant difference in outcome in the form of survival.
{"title":"Impact of Prenatal Diagnosis on the Management and Prognosis of Infants with Congenital Heart Disease- A Retrospective Study","authors":"P. Bhadane, Ravi Sonawane","doi":"10.7860/ijnmr/2022/58516.2364","DOIUrl":"https://doi.org/10.7860/ijnmr/2022/58516.2364","url":null,"abstract":"Introduction: Prenatal diagnosis is important in outcome of various congenital anomalies in recent times especially in congenital heart diseases. This study would help in recognising the importance of prenatal diagnosis and in understanding the management of newborns with congenital heart diseases. Aim: To evaluate the impact of prenatal diagnosis on the management and prognosis of infants with congenital heart disease. Materials and Methods: This retrospective study was conducted in Department of Paediatrics at Dr. Vasantrao Pawar Medical College, Nashik, Maharshtra, India, from January 2018 to January 2021. The study was performed on newborns who were diagnosed with Congenital Heart Diseases (CHD) during hospitalisation, in an inborn and outborn unit of Neonatal Intensive Care Unit (NICU). The data recorded for requirement of inotropes, ventilation, arterial blood gas analysis and outcome in the form of survival. The babies were classified into Prenatal ECHO (PNE) group and No Prenatal ECHO Available (NPEA) group, based on availability of prenatal Echocardiogram (ECHO) diagnostic report. CHDs were categorised into critical/major and minor. For the comparison of quantitative variables, Unpaired t-test/Mann- Whitney test was used. For the comparison of qualitative variable, Fisher’s-exact test/Chi-square test was used, as necessary. Results: There were 5000 admissions in the inborn and outborn neonatal unit during the study period, of which 159 cases had a diagnosis of CHDs. The PNE group consisted of 61 neonates who had been diagnosed with CHD and the NPEA group consisted of 67 neonates who were not antenatally diagnosed to have CHD. Ionotropic support needed for PNE group (4.5%) was comparatively lesser than NPEA group (14.3%). Need for ventilation was reduced in PNE group (4.5%) as compared to NPEA group (14.3%). Mean for serum lactate and serum bicarbonate was 3.49±2.58 and 16.24±4.31 in PNE group, whereas, it was 5.08±2.79 and 15.12±4.13 in NPEA group on admission in NICU. In management of critical CHDs, 2/31 (6.5%) babies died in PNE group compared to 11/37 (29.7%) in NPEA group (p-value=0.09). Conclusion: Antenatal diagnosis helps in meticulous management of neonates with congenital heart diseases in terms of fewer requirement of inotropes, need of ventilation and improved management. There was no significant difference in outcome in the form of survival.","PeriodicalId":31116,"journal":{"name":"Indian Journal of Neonatal Medicine and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71266627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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