S. Pop Trajković - Dinić, M. Stefanović, R. Živadinović, V. Antić, M. Trenkić, J. Milošević Stevanović
{"title":"COUNCELING PATIENTS WITH ENDOMETRIOSIS","authors":"S. Pop Trajković - Dinić, M. Stefanović, R. Živadinović, V. Antić, M. Trenkić, J. Milošević Stevanović","doi":"10.5633/amm.2021.0305","DOIUrl":"https://doi.org/10.5633/amm.2021.0305","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45705282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE SYNDROME OF THE INFERIOR VENA CAVA: A CASE REPORT","authors":"B. Mladenovic, Nikola Mladenović, Vesna Brzački","doi":"10.5633/amm.2021.0309","DOIUrl":"https://doi.org/10.5633/amm.2021.0309","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42578149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"METASTATIC EYE CANCER AS A PROGNOSTIC FACTOR FOR PATIENT SURVIVAL: A REVIEW ARTICLE","authors":"Milana Ristić, S. Cekić, N. Zlatanović","doi":"10.5633/amm.2021.0307","DOIUrl":"https://doi.org/10.5633/amm.2021.0307","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49196259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COGNITIVE AND LANGUAGE DEFICITS IN VASCULAR DEMENTIA","authors":"Slavica Vasilijević, M. Vuković, Lana Jerkić","doi":"10.5633/amm.2021.0312","DOIUrl":"https://doi.org/10.5633/amm.2021.0312","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44614767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danijela Jovančić Petković, G. Samardžija, G. Kostić, V. Bogičević
{"title":"A CASE REPORT OF RARE HEPATOSPLENIC T-CELL LYMPHOMA IN AN ADOLESCENT","authors":"Danijela Jovančić Petković, G. Samardžija, G. Kostić, V. Bogičević","doi":"10.5633/amm.2021.0310","DOIUrl":"https://doi.org/10.5633/amm.2021.0310","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45757494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mihajlo Gajić, B. Ilić, B. Bondžić, Z. Džambaski, Ana Filipović, G. Kocic, A. Šmelcerović
Xanthine oxidase (XO) is a versatile metalloflavoprotein enzyme that is best known for its rate-limiting role in the purine degradation pathway. Therapeutic inhibition of XO is based on its role in a variety of diseases that is attributed either to the hyperproduction of uric acid, or the hyperproduction of reactive oxygen species. Herein, we report the assessment of XO inhibitory properties of 24 1,2,3,4-tetrahydroisoquinoline derivatives, among which compound 16 exhibited IC 50 value of 135.72 ± 2.71 µM. The interaction of compound 16 with XO enzyme was simulated using the Site Finder module, molecular docking and molecular dynamics. Molecular modeling suggests that interactions with Met 1038, Gln 1040, Thr 1077, Gln 1194 and Val 1259 are an important factor for inhibitor affinity toward the XO enzyme. Our proposed binding model might be beneficial for the discovery of new active 1,2,3,4-tetrahydroisoquino-line-based inhibitors of XO enzyme. Acta Medica Medianae 2021;60(1):48-55.
{"title":"XANTHINE OXIDASE INHIBITORY PROPERTIES OF 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES","authors":"Mihajlo Gajić, B. Ilić, B. Bondžić, Z. Džambaski, Ana Filipović, G. Kocic, A. Šmelcerović","doi":"10.5633/AMM.2021.0106","DOIUrl":"https://doi.org/10.5633/AMM.2021.0106","url":null,"abstract":"Xanthine oxidase (XO) is a versatile metalloflavoprotein enzyme that is best known for its rate-limiting role in the purine degradation pathway. Therapeutic inhibition of XO is based on its role in a variety of diseases that is attributed either to the hyperproduction of uric acid, or the hyperproduction of reactive oxygen species. Herein, we report the assessment of XO inhibitory properties of 24 1,2,3,4-tetrahydroisoquinoline derivatives, among which compound 16 exhibited IC 50 value of 135.72 ± 2.71 µM. The interaction of compound 16 with XO enzyme was simulated using the Site Finder module, molecular docking and molecular dynamics. Molecular modeling suggests that interactions with Met 1038, Gln 1040, Thr 1077, Gln 1194 and Val 1259 are an important factor for inhibitor affinity toward the XO enzyme. Our proposed binding model might be beneficial for the discovery of new active 1,2,3,4-tetrahydroisoquino-line-based inhibitors of XO enzyme. Acta Medica Medianae 2021;60(1):48-55.","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42666115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Igić, B. Stojković, A. Mitić, Aleksandar Acović, Kosta Todorović, A. Todorović, D. Sokolović, Marija Igić
The aim of this study was to analyze injuries to the primary teeth and adjacent soft tissues in relation to the gender and age of injured children, type of injury, place, and mechanism of injury. The study enrolled 115 children (71 boys and 44 girls) managed at the Dentistry Clinic, Faculty of Medicine, University of Niš, in the period 2009-2019. The information about the type of injury, place, and mechanism of injury were obtained from the medical records of the patients aged 1-5 years. Our analysis established that there were statistically significantly (p < 0.05) more injured boys (61.74%) than girls (38.26%). Subluxation was the most common primary teeth injury, present in 60 (52.17%) children and was statistically significantly more prevalent compared to other injuries (p < 0.001). Of the injuries to the adjacent soft tissues, laceration was statistically significantly more common than other soft tissue injuries (p < 0.001). Children were most commonly injured at their homes (52.17%), and rarely in their day nurseries (3.48%). Falling was the most common cause of injuries (63.48%). Based on the obtained results, a conclusion may be drawn that boys were more commonly injured compared to girls, and that falls were the most common cause. Injuries usually occurred at the age of about 2 years. Subluxation was the most common injury, and children usually got injured at their own home.
{"title":"INJURIES TO THE PRIMARY TEETH AND SOFT TISSUES IN CHILDREN IN NIŠ, SERBIA","authors":"Ana Igić, B. Stojković, A. Mitić, Aleksandar Acović, Kosta Todorović, A. Todorović, D. Sokolović, Marija Igić","doi":"10.5633/AMM.2021.0107","DOIUrl":"https://doi.org/10.5633/AMM.2021.0107","url":null,"abstract":"The aim of this study was to analyze injuries to the primary teeth and adjacent soft tissues in relation to the gender and age of injured children, type of injury, place, and mechanism of injury. The study enrolled 115 children (71 boys and 44 girls) managed at the Dentistry Clinic, Faculty of Medicine, University of Niš, in the period 2009-2019. The information about the type of injury, place, and mechanism of injury were obtained from the medical records of the patients aged 1-5 years. Our analysis established that there were statistically significantly (p < 0.05) more injured boys (61.74%) than girls (38.26%). Subluxation was the most common primary teeth injury, present in 60 (52.17%) children and was statistically significantly more prevalent compared to other injuries (p < 0.001). Of the injuries to the adjacent soft tissues, laceration was statistically significantly more common than other soft tissue injuries (p < 0.001). Children were most commonly injured at their homes (52.17%), and rarely in their day nurseries (3.48%). Falling was the most common cause of injuries (63.48%). Based on the obtained results, a conclusion may be drawn that boys were more commonly injured compared to girls, and that falls were the most common cause. Injuries usually occurred at the age of about 2 years. Subluxation was the most common injury, and children usually got injured at their own home.","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45784922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mirna Zelić, J. Todorović, Dusko Pavlovic, Lana Jerkić
{"title":"THE RELATIONSHIP BETWEEN LESION LOCALIZATION AND SWALLOWING DISORDERS","authors":"Mirna Zelić, J. Todorović, Dusko Pavlovic, Lana Jerkić","doi":"10.5633/AMM.2021.0112","DOIUrl":"https://doi.org/10.5633/AMM.2021.0112","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":"60 1","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43255723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the study was to describe a study of 43 patients operated using a transobturator tape (TOT). A prospective study was performed on forty free patients operated between 2014 and 2020. In all patients, the diagnosis of stress urinary incontinence (SUI) was based on clinical criteria: positive stress test or positive pad test, confirmed urethral hypermobility (> 30 degrees), ultrasound and bladder diary for three days. Cystoscopy was performed in all patients to document satisfactory bladder compliance and capacity, and to exclude ordinary pathology of the bladder. In all patients, TOT was performed. Follow up was performed one month, six months, and 12 months after the surgery. All patients, 42/43 (97.6%), were in a generally good preoperative health state according to American Society of Anesthesia grading system (ASA 1-2). The subjective cure was achieved in 36/43 (83.7%) patients after one year. The objective cure was achieved in 32/43 (74.7%) patients after one year. OAB was present preoperatively in 19/43 (44.1%) patients, and postoperatively in 9/43 (20.9%) patients (p < 0.02). Postoperative complications were minor (Clavien-Dindo grade ≤ 2) in 42/43 (97.6%) patients. Transobturator tape can be successfully performed in selected patients in a small municipal hospital. Acta Medica Medianae 2021;60(1):68-73.
{"title":"TRANSOBTURATOR TAPE FOR THE TREATMENT OF STRESS URINARY INCONTINENCE IN A SMALL MUNICIPAL HOSPITAL: A SINGLE SURGEON EXPERIENCE","authors":"S. Branković, I. Ignjatovic, B. Jovanovic","doi":"10.5633/AMM.2021.0109","DOIUrl":"https://doi.org/10.5633/AMM.2021.0109","url":null,"abstract":"The aim of the study was to describe a study of 43 patients operated using a transobturator tape (TOT). A prospective study was performed on forty free patients operated between 2014 and 2020. In all patients, the diagnosis of stress urinary incontinence (SUI) was based on clinical criteria: positive stress test or positive pad test, confirmed urethral hypermobility (> 30 degrees), ultrasound and bladder diary for three days. Cystoscopy was performed in all patients to document satisfactory bladder compliance and capacity, and to exclude ordinary pathology of the bladder. In all patients, TOT was performed. Follow up was performed one month, six months, and 12 months after the surgery. All patients, 42/43 (97.6%), were in a generally good preoperative health state according to American Society of Anesthesia grading system (ASA 1-2). The subjective cure was achieved in 36/43 (83.7%) patients after one year. The objective cure was achieved in 32/43 (74.7%) patients after one year. OAB was present preoperatively in 19/43 (44.1%) patients, and postoperatively in 9/43 (20.9%) patients (p < 0.02). Postoperative complications were minor (Clavien-Dindo grade ≤ 2) in 42/43 (97.6%) patients. Transobturator tape can be successfully performed in selected patients in a small municipal hospital. Acta Medica Medianae 2021;60(1):68-73.","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":"60 1","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41918729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Nikolić, T. Kostić, M. Marinkovic, M. Golubovic, T. Stojanovic, M. Manojlović, I. Petkovic
{"title":"EFFICIENCY EXAMINATION OF ANTIHYPERTENSIVE FIXED-DOSE COMBINATION IN PATIENTS PREVIOUSLY TREATED WITH ANTIHYPERTENSIVE MONOTHERAPY","authors":"N. Nikolić, T. Kostić, M. Marinkovic, M. Golubovic, T. Stojanovic, M. Manojlović, I. Petkovic","doi":"10.5633/AMM.2021.0111","DOIUrl":"https://doi.org/10.5633/AMM.2021.0111","url":null,"abstract":"","PeriodicalId":31409,"journal":{"name":"Acta Medica Medianae","volume":"60 1","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44223135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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