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In Vitro Antifungal Susceptibility of Candida Albicans Isolated from Yemeni Patients with Denture Stomatitis 也门义齿口炎患者白色念珠菌体外抗真菌敏感性研究
Pub Date : 2022-11-24 DOI: 10.31579/2643-6612/034
Hassan A. Al-Shamahy
Background and aims: Candida-associated denture stomatitis (CADS) is a common fungal infection in people who wear dentures. The main objectives of this study were to identify the causative agents of CADS and in vitro antifungal susceptibility testing (AFST) for Candida albicans in Yemeni patients with denture stomatitis. Methods: A total of 88 Candida spp. obtained from patients with denture stomatitis. Candida spp were identified using standard microbiological methods. The in-vitro antifungal susceptibility of Candida albicans. to fluconazole (FCZ), itraconazole (ICZ), voriconazole (VCZ), and amphotericin B (AMB) was evaluated using the E test strips. Interpretive sensitivity criteria for antifungal breakpoints were adapted from the Clinical and Laboratory Standards Institute (CLSI). Results: Overall, C. albicans was the most commonly isolated species (𝑛 = 60; 68.2%), followed by C. glabrata (𝑛 = 9; 10.2%), C. tropicalis (𝑛 = 7; 8%), and C. parapsilosis (𝑛 = 3; 3.4%). Voriconazole had the lowest geometric mean minimum inhibitory concentration which was 0.0418 𝜇g/ml for MIC50, and 0.957 𝜇g/ml for MIC90; followed by amphotericin B (AMB) in which MIC50 was 0.518 𝜇g/ml and for MIC90 was 1.06 𝜇g/ml. Conclusion: Our study showed that Candida albicans was the most prevalent Candida species in Yemeni patients with CADS and was susceptible to both azoles and amphotericin B. In addition, voriconazole could be a suitable alternative to antifungal agents currently used in the treatment of CADS, as well as in the treatment of recurrent Candidasis.
背景和目的:念珠菌相关性假牙口腔炎(CADS)是假牙佩戴者常见的真菌感染。本研究的主要目的是确定也门假牙口腔炎患者CADS的病原体和体外抗真菌药敏试验(AFST)。方法:从义齿口炎患者中采集念珠菌88株。采用标准微生物学方法对念珠菌进行鉴定。白色念珠菌体外抗真菌敏感性研究。采用E试纸对氟康唑(FCZ)、伊曲康唑(ICZ)、伏立康唑(VCZ)、两性霉素B (AMB)进行检测。抗真菌断点的解释敏感性标准改编自临床和实验室标准协会(CLSI)。结果:总体而言,白色念珠菌是最常见的分离种(𝑛= 60;68.2%),其次为光棘棘(𝑛= 9;10.2%),热带棘球绦虫(𝑛= 7;8%),和C. parapsilosis(𝑛= 3;3.4%)。Voriconazole的几何平均最小抑制浓度最低,MIC50为0.0418𝜇g/ml, MIC90为0.957𝜇g/ml;其次是两性霉素B (AMB), MIC50为0.518𝜇g/ml, MIC90为1.06𝜇g/ml。结论:我们的研究表明白色念珠菌是也门CADS患者中最常见的念珠菌种类,对唑类药物和两性霉素b均敏感,伏立康唑可作为目前治疗CADS的抗真菌药物的合适替代药物,也可用于治疗复发性念珠菌病。
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引用次数: 0
Counts of Damage Assessed following Head and Neck Cellulitis of Oral Origin 口腔源性头颈部蜂窝织炎后损伤评估计数
Pub Date : 2022-11-24 DOI: 10.31579/2643-6612/033
Nseme Etouckey Eric
Introduction: Cellulite is an inflammatory process of bacterial origin of cellulo-adipose tissue. Its evolution and management can be marked by complications that can induce sequelae to patients. The purpose of the study was to determine the counts of harm assessed following surgical management of head and neck cellulitis of oral origin in three hospitals in Yaounde. Methodology: A descriptive and retrospective study was conducted in three hospitals in the city of Yaounde during 2021 for 7 months. Included in our research were patients surgically treated for head and neck cellulitis from January 2010 to December 2018. The data collection was done with a pre-designed sheet and the analysis of the results obtained using the EPI info 7.2.2.6 software. Results: Out of 352 patients collected, male accounted for 63% of cases with a sex ratio of 1.69. The average age was 32.52 ± 11.4 years with extremes ranging from 1 to 73 years. About 46.88% worked in the informal sector. The main functional sequelae were edentulism (68.75%), and the average permanent functional deficit (PFD) was 1.61% ±1.15 with extremes between 0 and 7%. Permanent aesthetic damage (PEP) was mostly very mild, rated at 1/7 in 86.65% of cases. The suffering endured (SE) was mainly very mild, at 1/7 in 91.19% of cases. Conclusion: The counts of harm assessed following odontogenic head and neck cellulitis were aesthetic harm, suffering endured and permanent functional deficit.
脂肪团是由细菌引起的纤维脂肪组织炎症过程。它的发展和管理可以通过并发症来标志,这些并发症会给患者带来后遗症。该研究的目的是确定雅温得三家医院口腔源性头颈部蜂窝织炎手术治疗后评估的危害计数。方法:在2021年期间,在雅温得市的三家医院进行了为期7个月的描述性和回顾性研究。我们的研究纳入了2010年1月至2018年12月接受头颈部蜂窝织炎手术治疗的患者。使用预先设计的表格收集数据,并使用EPI info 7.2.2.6软件对结果进行分析。结果:352例患者中,男性占63%,性别比为1.69。平均年龄32.52±11.4岁,极值1 ~ 73岁。约46.88%的人在非正规部门工作。功能后遗症以缺牙(68.75%)为主,永久性功能缺损(PFD)平均为1.61%±1.15,极值为0 ~ 7%。永久性美观损伤(PEP)多为非常轻微,占86.65%,评分为1/7。所受痛苦(SE)以极轻为主,占91.19%病例的1/7。结论:牙源性头颈部蜂窝织炎的危害分为美观损害、忍受痛苦和永久性功能缺损。
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引用次数: 0
Evaluation of the Conformity of Care of Patients Hospitalized for Cervico-Facial Odontogenic Cellulitis in Yaounde-Cameroon 雅温得-喀麦隆颈-面牙源性蜂窝织炎住院患者护理一致性评价
Pub Date : 2022-11-24 DOI: 10.31579/2643-6612/037
Nokam Abena Marie Elvire
Introduction: Cervicofacial odontogenic cellulitis is a poly-bacterial inflammatory process of the cellulo-adipal tissue involving the dental organ. The severity of its clinical picture can compromise its treatment and cause death. The vital prognosis of a hospitalized patient depends on the conformity of his management conditions. It is in this perspective that this study was carried out with the aim of evaluating the conformity of care of patients hospitalised for odontogenic cervico-facial cellulitis in Yaounde. Material and method: This was a descriptive and retrospective study that took place over 7 months during 2022, including all patients hospitalised for cervico-facial cellulitis of oral origin during a 3-year period, from 1er January 2019 to 31 December 2021 at the Yaoundé Central Hospital (HCY), the Yaoundé University Hospital (CHUY) and the Efoulan District Hospital (HDE). Socio-demographic characteristics, clinical and therapeutic aspects, and compliance with management were recorded. Data collection was done with a pre-designed form and the results were processed and analysed using SPSS version 26.0 and Excel 2013. Results: Out of 134 patient records collected, 67% were male with a sex ratio of 2.04. The age range Age group The age group [20-40] represented 56% of the cases. About 52.2% of the patients worked in the informal sector, followed by 25.4% of pupils and students. Trismus was present in 92.5% of cases. Cellulitis was diffuse in 81.3% of cases, suppurative in 73.9% and acute in 71.6%. Dual therapy with 99.3% Penicillin and 97.8% Imidazole was used in 69.4% of cases; the first level of Paracetamol was used in 94% as an analgesic. Antimalarial drugs were associated with the initial treatment in 5.2% of cases. Incision and drainage used in 52% of cases. The prescribed care was notified and regularly administered in 73.1% of cases; the case fatality rate was 15.7%, with sepsis as the cause in 80% of cases. All the records included the identification, the reason for hospitalisation and the therapeutic prescription. The elements of the hospitalization report, the prescription established at discharge and the conclusion of the clinical examination were contained in 84.3%, 94.8% and 97.8% of cases respectively. Conclusion: cellulitis affects resourceful men. Even if the compliance of the management conditions was found to be fair, the prognosis is vital with the severity of the infection.
颈面牙源性蜂窝织炎是一种累及牙器官的蜂窝组织的多细菌炎症过程。其临床表现的严重程度可能危及其治疗并导致死亡。住院病人的生命预后取决于他的治疗条件是否符合。正是从这个角度来看,本研究的目的是评估雅温得牙源性颈面部蜂窝组织炎住院患者的护理一致性。材料和方法:这是一项描述性和回顾性研究,于2022年进行了7个多月,包括2019年1月1日至2021年12月31日期间在雅温得中心医院(HCY)、雅温得大学医院(CHUY)和Efoulan地区医院(HDE)因口腔源性颈面部蜂窝织炎住院的所有患者。记录社会人口学特征、临床和治疗方面以及对管理的依从性。采用预先设计的表格进行数据收集,使用SPSS 26.0和Excel 2013对结果进行处理和分析。结果:134例患者中,男性占67%,性别比为2.04。年龄层年龄层[20-40岁]占病例的56%。约52.2%的病人在非正规部门工作,其次是25.4%的小学生和学生。92.5%的病例出现牙关紧闭。蜂窝织炎81.3%为弥漫性,73.9%为化脓性,71.6%为急性。99.3%青霉素加97.8%咪唑双药治疗占69.4%;94%的患者使用第一级扑热息痛作为镇痛药。在5.2%的病例中,抗疟药物与初始治疗相关。52%的病例采用切开引流。73.1%的病例通报并定期执行了规定的护理;病死率为15.7%,败血症占80%。所有记录均包括身份、住院原因和治疗处方。住院报告内容、出院时处方内容和临床检查结论内容分别占84.3%、94.8%和97.8%。结论:蜂窝组织炎影响足智多谋的男性。即使发现符合管理条件是公平的,预后也与感染的严重程度有关。
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引用次数: 0
Complex Treatment of Internal TMJ Disorders in Patients with Different Bit Types 不同位型颞下颌关节紊乱的综合治疗
Pub Date : 2022-11-24 DOI: 10.31579/2643-6612/035
G. Hakobyan
Objective: To assess the impact of physiological and pathological types of occlusion on the effectiveness of the treatment of patients with internal disorders of the TMJ. Material and Methods: A comprehensive examination and treatment of 139 patients with internal TMJ disorders with subluxation and chronic dislocation of the articular disc was carried out. The patients were divided into three groups. All groups included patients with both physiological and pathological occlusion. The first group included 28 (20.1%) patients who were treated only with occlusal splint therapy; the second group included 95 (68.3%) patients who were treated with a combination of occlusal splint therapy and the use of arthrocentesis; in the third group (16 people (11.5%), along with splint therapy and arthrocentesis, TMJ arthroscopy was performed. The examination included a survey and examination of patients, a study of diagnostic models of the jaws to determine the types of occlusion and occlusal contacts, magnetic resonance imaging (MRI) and ultrasound examination (ultrasound) of the TMJ. Patients underwent a phased treatment, including occlusive splint therapy (stage I); with insufficient effectiveness - occlusive splint therapy and arthrocentesis (stage II); occlusive splint therapy and arthrocentesis in combination with arthroscopy (stage III of treatment). Results: As a result of the study, it turned out that the groups of patients differed significantly in the complexity and duration of the treatment. Thus, in patients with internal TMJ disorders and pathological type of occlusion, in 82.6% of cases, additional use of arthrocentesis was required and in 34.8% - arthroscopy (95 patients out of 139), while patients with physiological types of occlusion (orthognathic, progenic, biprogenic and direct) needed these treatments in 80.2% and 7.8% of cases, respectively In the groups of patients, the duration of therapy, as well as the number of arthrocentesis performed in patients at the second and third stages of treatment, significantly differed. In the first group, the duration of treatment was 6.2 months for patients with normal occlusion and 8.7 (p<0.01) months for patients with pathological occlusion; additional methods of treatment (arthrocentesis and arthroscopy) were not used. In the second and third groups of patients, the duration of treatment for patients with occlusion pathology was also longer: in the second group 4.9 and 6.8 (p<0.01) months for patients with physiological and pathological types of occlusion, respectively, in the third group with the use of splint therapy, arthrocentesis and arthroscopy in patients with normal occlusion was 13.1 (p<0.05) months, and in patients with occlusion pathology 14.5 months Conclusion: Patients with internal TMJ disorders need a comprehensive examination for the timely detection of occlusion pathologies. The relationship between internal TMJ disorders and the type of occlusion must always be taken into account in th
目的:探讨生理和病理类型的咬合对治疗颞下颌关节内部疾病疗效的影响。材料与方法:对139例伴有半脱位和慢性关节盘脱位的颞下颌关节内障碍患者进行综合检查和治疗。患者被分为三组。所有组均包括生理性和病理性闭塞患者。第一组28例(20.1%)患者仅接受咬合夹板治疗;第二组包括95例(68.3%)患者,采用咬合夹板联合关节穿刺治疗;第三组16例(11.5%),配合夹板治疗和关节穿刺,行TMJ关节镜检查。检查包括对患者进行调查和检查,研究颌骨诊断模型以确定咬合类型和咬合接触,并对TMJ进行磁共振成像(MRI)和超声检查(超声波)。患者接受分期治疗,包括闭塞夹板治疗(I期);效果不足-闭塞夹板治疗和关节穿刺(II期);闭塞夹板治疗和关节穿刺联合关节镜检查(III期治疗)。结果:研究结果显示,两组患者在治疗的复杂程度和持续时间上存在显著差异。因此,在患有TMJ内部疾病和病理性闭塞的患者中,82.6%的病例需要额外使用关节穿刺,34.8%的病例需要额外使用关节镜(139例中95例),而生理性闭塞(正颌、前颌、双颌和直接)的患者分别有80.2%和7.8%的病例需要这些治疗。在治疗的第二和第三阶段,患者进行关节穿刺的次数也有显著差异。第一组正常咬合组治疗时间为6.2个月,病理性咬合组治疗时间为8.7个月(p<0.01);没有使用其他治疗方法(关节穿刺和关节镜)。在第二组和第三组患者中,闭塞病理患者的治疗时间也更长:第二组生理性和病理性闭塞患者的治疗时间分别为4.9和6.8个月(p<0.01),第三组使用夹板治疗、关节穿刺和关节镜治疗的正常闭塞患者的治疗时间为13.1个月(p<0.05),闭塞病理患者的治疗时间为14.5个月。TMJ内障碍患者需要全面检查,及时发现咬合病理。在选择进一步的治疗策略和治疗计划时,必须考虑TMJ内障碍与咬合类型的关系,以达到最佳效果。
{"title":"Complex Treatment of Internal TMJ Disorders in Patients with Different Bit Types","authors":"G. Hakobyan","doi":"10.31579/2643-6612/035","DOIUrl":"https://doi.org/10.31579/2643-6612/035","url":null,"abstract":"Objective: To assess the impact of physiological and pathological types of occlusion on the effectiveness of the treatment of patients with internal disorders of the TMJ. Material and Methods: A comprehensive examination and treatment of 139 patients with internal TMJ disorders with subluxation and chronic dislocation of the articular disc was carried out. The patients were divided into three groups. All groups included patients with both physiological and pathological occlusion. The first group included 28 (20.1%) patients who were treated only with occlusal splint therapy; the second group included 95 (68.3%) patients who were treated with a combination of occlusal splint therapy and the use of arthrocentesis; in the third group (16 people (11.5%), along with splint therapy and arthrocentesis, TMJ arthroscopy was performed. The examination included a survey and examination of patients, a study of diagnostic models of the jaws to determine the types of occlusion and occlusal contacts, magnetic resonance imaging (MRI) and ultrasound examination (ultrasound) of the TMJ. Patients underwent a phased treatment, including occlusive splint therapy (stage I); with insufficient effectiveness - occlusive splint therapy and arthrocentesis (stage II); occlusive splint therapy and arthrocentesis in combination with arthroscopy (stage III of treatment). Results: As a result of the study, it turned out that the groups of patients differed significantly in the complexity and duration of the treatment. Thus, in patients with internal TMJ disorders and pathological type of occlusion, in 82.6% of cases, additional use of arthrocentesis was required and in 34.8% - arthroscopy (95 patients out of 139), while patients with physiological types of occlusion (orthognathic, progenic, biprogenic and direct) needed these treatments in 80.2% and 7.8% of cases, respectively In the groups of patients, the duration of therapy, as well as the number of arthrocentesis performed in patients at the second and third stages of treatment, significantly differed. In the first group, the duration of treatment was 6.2 months for patients with normal occlusion and 8.7 (p<0.01) months for patients with pathological occlusion; additional methods of treatment (arthrocentesis and arthroscopy) were not used. In the second and third groups of patients, the duration of treatment for patients with occlusion pathology was also longer: in the second group 4.9 and 6.8 (p<0.01) months for patients with physiological and pathological types of occlusion, respectively, in the third group with the use of splint therapy, arthrocentesis and arthroscopy in patients with normal occlusion was 13.1 (p<0.05) months, and in patients with occlusion pathology 14.5 months Conclusion: Patients with internal TMJ disorders need a comprehensive examination for the timely detection of occlusion pathologies. The relationship between internal TMJ disorders and the type of occlusion must always be taken into account in th","PeriodicalId":320549,"journal":{"name":"Dentistry and Oral Maxillofacial Surgery","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116595454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microscopy Analyses Reveal the Parasitism of Entamoeba gingivalis in Periodontitis: An Observational Study 显微镜分析揭示牙周炎中牙龈内阿米巴的寄生:一项观察性研究
Pub Date : 2022-11-24 DOI: 10.31579/2643-6612/042
Mark Bonner DMD
Background: Whereas the periodontal microbiota is well described, its non-bacterial component needs a better understanding. Metagenomic analyses show a strong increase of the protozoan Entamoeba gingivalis in inflamed periodontal pockets. Its presence is associated with periodontal deterioration and pockets typically 3mm or more in depth. The aim of this study is to observe the amoeba within the biofilm during active disease. Materials and Methods: Here, we present results of a phase contrast microscopy-based observation of amoebae in periodontal patients’ subgingival plaque from infected sulcus. Plaque samples from deepest part of sulcus are picked up and spread out between blade and coverslip in patient saliva medium. We relate significant behavior of the parasite during active periodontal disease. Results: From low power observation, parasite is quite frequent. Once targeted, high power observation confirms amoeban anatomy and presence. We observed a high degree of amoeba locomotion and movements toward specific environments within the subgingival plaque. This was accompanied by the formation of “channels” within the biofilm. We also present evidence of adhesion to human cells as well as characteristically parasitic behavior. Specifically, we observed the intrusion of amoeba pseudopods into leukocytes coupled with a decrease in leukocyte intracellular granular activity. We documented both single trogocytic processes and trogocytosis through multiple pseudopods. In addition to leukocytes, we also observed trogocytosis of red blood cells. Parasitic behavior was also evident from the observation of amoebae digesting the nuclei of multiple vacuolar white blood cells, simultaneously. Following trogocytosis, polynuclear neutrophils had the appearance of ghost cells. Finally, we show evidence for amoeba nesting and reproduction within periodontal pockets. Conclusion: Phase contrast microscopy of periodontal biofilms strongly suggests that E. gingivalis escapes the first lines of innate defenses and promotes a pathological state. Trogocytosis and exonucleophagy processes targeting neutrophils could consequently disrupt neutrophil extracellular traps activity and normal apoptotic function, a vital component of wound healing. This study points to Entamoeba gingivalis as a microbe involved in the inflammatory process during periodontitis and as a driver of the disease rather than a harmless commensal species.
背景:虽然牙周微生物群被很好地描述,但其非细菌成分需要更好地了解。宏基因组分析显示,发炎的牙周袋中牙龈内阿米巴原虫的数量明显增加。它的存在与牙周恶化有关,通常有3毫米或更深的口袋。本研究的目的是观察活动性疾病期间生物膜内的变形虫。材料和方法:在这里,我们报告了基于相衬显微镜观察牙周患者感染龈下菌斑的变形虫的结果。在患者唾液培养基中,从沟的最深处取出菌斑样本,在刀片和盖盖之间展开。我们将寄生虫在活动性牙周病期间的显著行为联系起来。结果:低倍镜观察,寄生虫较多。一旦锁定目标,高倍观测证实了变形虫的解剖和存在。我们观察到高度的阿米巴运动和运动到牙龈下菌斑内的特定环境。这伴随着生物膜内“通道”的形成。我们还提出了粘附到人类细胞的证据,以及典型的寄生行为。具体来说,我们观察到伪足变形虫侵入白细胞,同时白细胞胞内颗粒活性降低。我们记录了单一的凿胞过程和通过多个假足的凿胞过程。除白细胞外,我们还观察到红细胞的巨噬细胞增多。寄生行为也很明显,从观察阿米巴虫消化多个空泡白细胞的细胞核,同时。单核细胞增多后,多核中性粒细胞表现为鬼影细胞。最后,我们展示了变形虫在牙周袋内筑巢和繁殖的证据。结论:牙周生物膜的相衬显微镜检查强烈提示牙龈原丝酵母菌逃离了先天防御的第一道防线,并促进了一种病理状态。以中性粒细胞为目标的细胞吞噬和外核吞噬过程可能破坏中性粒细胞胞外陷阱活性和正常的凋亡功能,这是伤口愈合的重要组成部分。本研究指出牙龈内阿米巴是一种参与牙周炎炎症过程的微生物,是疾病的驱动因素,而不是一种无害的共生物种。
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引用次数: 0
Maximum Mouth Opening among Libyan Population 利比亚人口中最大的开口
Pub Date : 2022-01-06 DOI: 10.31579/2643-6612/023
Abdalmawla Alhussin Ali, Karima Ali Belgasem
Restricted mouth opening may be associated with musculoskeletal disorder or due to orofacial infections and trauma, as well as chronic condition such as disorders of the temporomandibular joint and tumors. Aim This study was aimed to measure the maximum mouth opening among the young healthy patients of Sirte city. Methods A total of 100 participates, 42 males and 58 females, in the age range of 12-20 years attending the orthodontic clinic in Sirte city were studied. The Participates were asked to open their mouth maximally until no further opening was possible. The distance from the incisal edge of the upper incisor teeth to the incisal edge of the lower incisor teeth was measured using a digital calibrated. All data were analyzed using SPSS program and simple descriptive statistics of MMO with regard to gender and age were reported. Results The mean maximal mouth opening for males was 49.35(4.5) mm and mean maximal mouth opening for females was 47. 11(4.7) mm. Mouth opening differences among different gender was compared which showed male had wider mouth opening but the difference was not statistically significant. Statistically significant differences were found between age groups. Conclusions The results of this study indicated that the positive relationship between MMO and age and the base line data was achieved in our study which needs to be validated further by conducting study in larger population.
张嘴受限可能与肌肉骨骼疾病或由于口面部感染和创伤,以及慢性疾病,如颞下颌关节疾病和肿瘤有关。目的本研究旨在了解苏尔特市年轻健康患者的最大张嘴量。方法选取苏尔特市正畸门诊就诊的100例患者,其中男42例,女58例,年龄12 ~ 20岁。参与者被要求最大程度地张开嘴,直到无法再张开为止。上切牙切缘到下切牙切缘的距离用数字校准仪测量。所有数据采用SPSS程序进行分析,并对MMO患者的性别和年龄进行简单描述性统计。结果男性平均最大开口49.35(4.5)mm,女性平均最大开口47 mm。11(4.7) mm。不同性别的口张度差异比较,男性的口张度更大,但差异无统计学意义。在不同年龄组之间发现了统计学上的显著差异。结论本研究结果表明,我们的研究获得了MMO与年龄和基线数据呈正相关关系,需要通过更大人群的研究进一步验证。
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引用次数: 0
Aggregatibacter Actinomycetemcomitans: Current Overview 聚合菌放线菌comitans:当前概述
Pub Date : 2022-01-06 DOI: 10.31579/2643-6612/025
Sharayu Rajendra Dhande, R. Hedge, Sangeeta Muglikar
Aggregatibacter Actinomycetemcomitans is one of the most aggressive pathobionts studied to the date. It encodes numerous putative toxins, the complex interplay of these toxins with the subgingival microbiota affects host defense mechanisms leading to rigorous destruction of the periodontium further causing loss of the tooth. The diversity in the field of oral microbiology has renewed interest among clinicians to study the bacterial species in particular. The aim of this review is to provide a comprehensive update on this commensal bacterium and co-relation of its virulence factors with the periodontal disease.
放线菌是迄今为止研究的最具侵袭性的病原体之一。它编码许多假定的毒素,这些毒素与龈下微生物群的复杂相互作用影响宿主防御机制,导致牙周组织的严重破坏,进一步导致牙齿脱落。口腔微生物学领域的多样性重新引起了临床医生对细菌种类研究的兴趣。这篇综述的目的是提供一个全面的更新的共生细菌及其毒力因子与牙周病的相互关系。
{"title":"Aggregatibacter Actinomycetemcomitans: Current Overview","authors":"Sharayu Rajendra Dhande, R. Hedge, Sangeeta Muglikar","doi":"10.31579/2643-6612/025","DOIUrl":"https://doi.org/10.31579/2643-6612/025","url":null,"abstract":"Aggregatibacter Actinomycetemcomitans is one of the most aggressive pathobionts studied to the date. It encodes numerous putative toxins, the complex interplay of these toxins with the subgingival microbiota affects host defense mechanisms leading to rigorous destruction of the periodontium further causing loss of the tooth. The diversity in the field of oral microbiology has renewed interest among clinicians to study the bacterial species in particular. The aim of this review is to provide a comprehensive update on this commensal bacterium and co-relation of its virulence factors with the periodontal disease.","PeriodicalId":320549,"journal":{"name":"Dentistry and Oral Maxillofacial Surgery","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128891068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gingival Parasitic Infections as a Contributor to Periodontitis: Identification and Treatment 牙龈寄生虫感染对牙周炎的影响:鉴定和治疗
Pub Date : 2022-01-06 DOI: 10.31579/2643-6612/026
Gregori M Kurtzman, A. Aalam, M. Bonner, A. Krivitsky, Madison Kaplan Zusman
Objectives: Parasites play a role in the pathology of periodontal disease with the protozoan Entamoeba gingivalis frequently observed when periodontal disease is present and has been ignored as a contributor to periodontal disease. Identification of the presence of periodontal parasites and how to treat them to eliminate their contribution to periodontal disease will be addressed. Methods: The first phase of therapy is reconstituting a normal commensal biofilm with minimal supragingival calculus removal to limit potential for the parasites to invade the soft tissue lining of the pocket and potentially spread related to the bleeding capillaries. At the fourth month, a systemic antiparasitic medication (metronidazole) is added. The second phase of therapy consists of four monthly subgingival calculus removal using sonic or ultrasonic instruments. Microscopic evaluation is used to confirm the absence of parasites. Results: The Bonner Method is nonsurgical. Pocket closure and osseous regrowth, without supplemental grafting help confirm healing and continued use of the homecare regime allow the patient to maintain gingival health long-term. Microbiota microscopic examination at every visit during active treatment confirms healing and elimination of the parasites. Conclusions: Patient who have traditionally avoided dental treatment or have experienced traditional surgery in the past easily accept antiparasitic treatment, which is reached from clinical and microscopic co-examination. Many of these patients are seeking an alternative to traditional surgery and are more comfortable with the basics behind the protocol once they have seen their biofilm under video from their microscopic sampling. Clinical significance: The subject of this article has clinical relevance, as parasites are an unrecognized contributor to periodontal disease that is frequently not identified or understood. This article discusses its clinical relevance, how to identify its presence and treatment to eliminate the parasite as part of periodontal treatment. The authors feel that this will have relevance to dental hygienists as they are the practitioner who would be first to identify its presence and provide treatment in the dental practice.
目的:寄生虫在牙周病的病理中发挥作用,当牙周病存在时,经常观察到牙龈内阿米巴原虫,但它一直被忽视为牙周病的一个因素。识别牙周寄生虫的存在,以及如何治疗它们以消除它们对牙周病的贡献将被解决。方法:第一阶段的治疗是重建正常的共生生物膜,尽量减少龈上结石的清除,以限制寄生虫侵入口袋软组织衬里的可能性,并可能扩散到出血的毛细血管。在第四个月时,添加全身抗寄生虫药物(甲硝唑)。第二阶段的治疗包括每月4次使用声波或超声仪器清除龈下结石。显微镜检查用来确认没有寄生虫。结果:Bonner法为非手术方法。袋闭合和骨再生,无需补充移植,有助于确认愈合和继续使用家庭护理方案,使患者长期保持牙龈健康。在积极治疗期间,每次就诊时进行微生物群显微镜检查,确认寄生虫的愈合和消除。结论:传统上不接受牙科治疗或接受过传统手术的患者容易接受抗寄生虫治疗,这是临床和镜检共同得出的结论。这些患者中的许多人正在寻求传统手术的替代方案,一旦他们在显微镜取样的视频中看到他们的生物膜,他们就会对方案背后的基础知识感到更舒服。临床意义:这篇文章的主题具有临床相关性,因为寄生虫是牙周病的一种未被认识的贡献者,通常不被识别或理解。本文讨论其临床意义,如何识别其存在和治疗,以消除寄生虫作为牙周治疗的一部分。作者认为,这将与牙科保健员有关,因为他们是首先确定其存在并在牙科实践中提供治疗的从业者。
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引用次数: 0
Evaluation of Aerosol and Splatter Production using Dental Handpieces and Ultrasonic Scalers during Dental Procedures: A Pilot Study 评估牙科手术过程中使用牙科手机和超声波清洗机产生的气溶胶和飞溅物:一项试点研究
Pub Date : 2022-01-06 DOI: 10.31579/2643-6612/027
Pamela L. Alberto, M. Conte, Thomas M Scorziello
There have been many articles written about aerosols and splatter during dental procedures with the potential for disease transmission. Due to the global COVID-19 pandemic, aerosol production during dental procedures has been considered a potential disease transmission pathway. Since there is no documented cases of dental professionals acquiring SARS-Cov1 or COVID-19, we decided to see how much aerosol is produced by a Dental High speed drill and ultrasonic scaler. Also if the use of high volume suction can eliminate any aerosol transmission. A pilot study using Glo Germ in the water to evaluate under blacklight the aerosol pattern and spread produced by a high speed dental handpiece and an ultrasonic scaler was performed. The results found that high volume suction using an 8mm diameter suction tip eliminated aerosol spray spread with a high speed dental handpiece. Minimal aerosol spread was found with the use of a cavitron scaler.
有许多文章写了气溶胶和飞溅在牙科过程中与潜在的疾病传播。由于全球COVID-19大流行,牙科手术期间产生的气溶胶被认为是一种潜在的疾病传播途径。由于没有记录在案的牙科专业人员感染SARS-Cov1或COVID-19的病例,我们决定看看牙科高速钻头和超声波清洗机产生了多少气溶胶。此外,如果使用大容量吸力可以消除任何气溶胶的传播。利用Glo Germ在水中进行了一项初步研究,以评估在黑光下高速牙科手机和超声波清洗机产生的气溶胶模式和传播。结果发现,使用直径8mm的吸头进行大容量吸吸,消除了高速牙科机头产生的气溶胶喷雾扩散。使用空腔电子秤发现气溶胶扩散最小。
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引用次数: 0
Oral Manifestations of Malnutrition and Causes 口腔营养不良的表现及原因
Pub Date : 2022-01-06 DOI: 10.31579/2643-6612/022
B. Helail
Studies by health specialists show that most people, both adults, and children,are vulnerable to the effects of malnutrition and oral diseases if they do not pay attention to their diet. In cases where patients were screened for malnourishment, the findings indicated that oral health was the common risk factor. Also, dentists in other case studies revealed that their patients lacked proper dietary schedules.Therefore, several investigations and findings indicate that several conditions in the mouth, such as periodontal diseases, ulcerative gingivitis, oral cancer, and edentulism, are all caused by various nutritional deficiencies; hence, they are signs of malnutrition.
健康专家的研究表明,大多数人,无论是成人还是儿童,如果不注意饮食,都容易受到营养不良和口腔疾病的影响。在对患者进行营养不良筛查的情况下,调查结果表明口腔健康是常见的危险因素。此外,牙医在其他案例研究中发现,他们的病人缺乏适当的饮食计划。因此,几项调查和结果表明,口腔中的几种疾病,如牙周病、溃疡性牙龈炎、口腔癌和牙髓症,都是由各种营养缺乏引起的;因此,它们是营养不良的迹象。
{"title":"Oral Manifestations of Malnutrition and Causes","authors":"B. Helail","doi":"10.31579/2643-6612/022","DOIUrl":"https://doi.org/10.31579/2643-6612/022","url":null,"abstract":"Studies by health specialists show that most people, both adults, and children,are vulnerable to the effects of malnutrition and oral diseases if they do not pay attention to their diet. In cases where patients were screened for malnourishment, the findings indicated that oral health was the common risk factor. Also, dentists in other case studies revealed that their patients lacked proper dietary schedules.Therefore, several investigations and findings indicate that several conditions in the mouth, such as periodontal diseases, ulcerative gingivitis, oral cancer, and edentulism, are all caused by various nutritional deficiencies; hence, they are signs of malnutrition.","PeriodicalId":320549,"journal":{"name":"Dentistry and Oral Maxillofacial Surgery","volume":"260 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134446536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Dentistry and Oral Maxillofacial Surgery
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