A rare case of unicornuate uterus with interstitial ectopic pregnancy (IEP) was diagnosed using three-dimensional transvaginal ultrasound (3D-TVUS). The ultrasound revealed a "lancet-shaped" endometrial corona, a gestational sac near the uterus base extending towards the uterine serosa, and visible interstitial lines. The patient underwent laparoscopic surgery for a lesion in the right fallopian tube. 3D-TVUS was crucial in precisely locating the gestational sac, aiding in effective treatment. Interstitial ectopic pregnancies risk severe hemorrhaging upon rupture. Rapid, accurate diagnosis is vital for lifesaving treatment and preventing critical complications.
{"title":"Commentary: Three-dimensional transvaginal ultrasound diagnosis of interstitial ectopic pregnancy in a unicornuate uterus: A case report","authors":"Yanhua Dong, Hezhou Li, Runwei Liang","doi":"10.46439/hematol.3.011","DOIUrl":"https://doi.org/10.46439/hematol.3.011","url":null,"abstract":"A rare case of unicornuate uterus with interstitial ectopic pregnancy (IEP) was diagnosed using three-dimensional transvaginal ultrasound (3D-TVUS). The ultrasound revealed a \"lancet-shaped\" endometrial corona, a gestational sac near the uterus base extending towards the uterine serosa, and visible interstitial lines. The patient underwent laparoscopic surgery for a lesion in the right fallopian tube. 3D-TVUS was crucial in precisely locating the gestational sac, aiding in effective treatment. Interstitial ectopic pregnancies risk severe hemorrhaging upon rupture. Rapid, accurate diagnosis is vital for lifesaving treatment and preventing critical complications.","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"64 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on “Ultrasmall polyvinylpyrrolidone-modified iridium nanoparticles with antioxidant and anti-inflammatory activity for acute pancreatitis alleviation”","authors":"Wenzhang Jin, Xiang Su","doi":"10.46439/hematol.3.012","DOIUrl":"https://doi.org/10.46439/hematol.3.012","url":null,"abstract":"","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Taking BAFF-R targeting CAR T-cells on the road","authors":"M. Gadd, Hong Qin","doi":"10.46439/hematol.3.010","DOIUrl":"https://doi.org/10.46439/hematol.3.010","url":null,"abstract":"","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139957938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Xi-Ming Li, Qing-Song Hou, Shu-Fang Wang, Jian-Min Chen, Wei Yao, Yan-Yan Fu, Li- Chuan Liu, Ren-Shu Li, Xiao-Qiang Yan
{"title":"Efbemalenograstim alfa, a long-acting granulocyte colony-stimulating factor, a novel dimeric G-CSF Fc fusion protein for reducing the risk of febrile neutropenia following chemotherapy","authors":"Simon Xi-Ming Li, Qing-Song Hou, Shu-Fang Wang, Jian-Min Chen, Wei Yao, Yan-Yan Fu, Li- Chuan Liu, Ren-Shu Li, Xiao-Qiang Yan","doi":"10.46439/hematol.2.009","DOIUrl":"https://doi.org/10.46439/hematol.2.009","url":null,"abstract":"","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132887327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Khojah, Hadeel Alshareef, Lujain Alzahrani, M. Binhussein, A. Bukhari, Imad M Khojah
WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome is a rare primary immunodeficiency disorder characterized by susceptibility to human papillomavirus (HPV) infections, neutropenia, and hypogammaglobulinemia. WHIM syndrome is caused by a gain-of-function mutation CXCR4, leading to increased responsiveness of neutrophils and lymphocytes to CXCL12. This results in an accumulation of atypical hypersegmented mature neutrophils in the bone marrow and peripheral blood neutropenia. This case report discusses a 10-year-old girl who was diagnosed with WHIM syndrome at the age of four years following Haemophilus influenzae meningitis. She was found to have Tetralogy of Fallot at birth, which was surgically repaired when she was one year old. She was also found to have significant neutropenia during surgery and received multiple doses of G-CSF with a good response. She presented to the hospital at the age of four years with fever, neck stiffness, lethargy, and headache and was diagnosed with H. influenzae meningitis. Her immunology workup revealed significant neutropenia and hypogammaglobulinemia, as well as low antibody levels to H. influenza type B, tetanus toxoid, and Streptococcus pneumonia, despite up-to-date vaccination. Furthermore, decreased levels of T cells and B cells were detected. The patient was started on IgG replacement therapy and Bactrim prophylaxis. Bone marrow biopsy revealed granulocytic hyperplasia and occasional hypersegmented neutrophils, suggesting myelokathexis. Genetic testing revealed a heterozygous CXCR4 mutation with a premature stop codon (p.Ser338Ter), confirming the diagnosis of WHIM syndrome. This case report highlights the association of WHIM syndrome with congenital heart defects, such as Tetralogy of Fallot. A literature review revealed three other cases of congenital heart defects in patients with WHIM syndrome, indicating a potential role for CXCR4 and CXCL12 in septum formation. The rarity of the disorder and the lack of a universal screening tool makes the diagnosis of WHIM syndrome difficult. Therefore, physicians should consider WHIM syndrome in patients with congenital heart defects, particularly if they have recurrent HPV infections, neutropenia, and hypogammaglobulinemia.
{"title":"Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome and tetralogy of fallot; Case report and literature review","authors":"A. Khojah, Hadeel Alshareef, Lujain Alzahrani, M. Binhussein, A. Bukhari, Imad M Khojah","doi":"10.46439/hematol.2.007","DOIUrl":"https://doi.org/10.46439/hematol.2.007","url":null,"abstract":"WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome is a rare primary immunodeficiency disorder characterized by susceptibility to human papillomavirus (HPV) infections, neutropenia, and hypogammaglobulinemia. WHIM syndrome is caused by a gain-of-function mutation CXCR4, leading to increased responsiveness of neutrophils and lymphocytes to CXCL12. This results in an accumulation of atypical hypersegmented mature neutrophils in the bone marrow and peripheral blood neutropenia. This case report discusses a 10-year-old girl who was diagnosed with WHIM syndrome at the age of four years following Haemophilus influenzae meningitis. She was found to have Tetralogy of Fallot at birth, which was surgically repaired when she was one year old. She was also found to have significant neutropenia during surgery and received multiple doses of G-CSF with a good response. She presented to the hospital at the age of four years with fever, neck stiffness, lethargy, and headache and was diagnosed with H. influenzae meningitis. Her immunology workup revealed significant neutropenia and hypogammaglobulinemia, as well as low antibody levels to H. influenza type B, tetanus toxoid, and Streptococcus pneumonia, despite up-to-date vaccination. Furthermore, decreased levels of T cells and B cells were detected. The patient was started on IgG replacement therapy and Bactrim prophylaxis. Bone marrow biopsy revealed granulocytic hyperplasia and occasional hypersegmented neutrophils, suggesting myelokathexis. Genetic testing revealed a heterozygous CXCR4 mutation with a premature stop codon (p.Ser338Ter), confirming the diagnosis of WHIM syndrome. This case report highlights the association of WHIM syndrome with congenital heart defects, such as Tetralogy of Fallot. A literature review revealed three other cases of congenital heart defects in patients with WHIM syndrome, indicating a potential role for CXCR4 and CXCL12 in septum formation. The rarity of the disorder and the lack of a universal screening tool makes the diagnosis of WHIM syndrome difficult. Therefore, physicians should consider WHIM syndrome in patients with congenital heart defects, particularly if they have recurrent HPV infections, neutropenia, and hypogammaglobulinemia.","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129346881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Circular RNAs (circRNAs) are a novel type of covalently closed RNAs recently found to be involved in several physiological and pathological processes. A series of studies have proved that cyclic RNAs are related with the genesis and development of tumors, for example circ_0007841 and PVT1. Some circRNAs are strictly related to advanced clinical stage and poor prognosis, including circPTK2, circ-RNF217, circ-AFF2, circ-MYBL2, circ_0069767, circ-CDYL, circ_0000142, circRNA_101237 and exo-circMYC. In addition, circRNAs are involved in drug resistance and complications, they are circ-CCT3, Circ-007841, ciRS-7,circPVT1, circ_0001821, Exo-circ-G042080 and circCHEK1_246aa. Therefore, we propose that circRNAs can be considered as potential diagnostic and prognostic markers, which can induce chemoresistance, and might indicate novel therapeutic targets for multiple myeloma. Targeting cyclic RNA therapy will bring spring to the treatment of multiple myeloma.
{"title":"Research progress and prospect of circular RNA in multiple myeloma","authors":"Wenjun Yu, Fan Zhou","doi":"10.46439/hematol.2.008","DOIUrl":"https://doi.org/10.46439/hematol.2.008","url":null,"abstract":"Circular RNAs (circRNAs) are a novel type of covalently closed RNAs recently found to be involved in several physiological and pathological processes. A series of studies have proved that cyclic RNAs are related with the genesis and development of tumors, for example circ_0007841 and PVT1. Some circRNAs are strictly related to advanced clinical stage and poor prognosis, including circPTK2, circ-RNF217, circ-AFF2, circ-MYBL2, circ_0069767, circ-CDYL, circ_0000142, circRNA_101237 and exo-circMYC. In addition, circRNAs are involved in drug resistance and complications, they are circ-CCT3, Circ-007841, ciRS-7,circPVT1, circ_0001821, Exo-circ-G042080 and circCHEK1_246aa. Therefore, we propose that circRNAs can be considered as potential diagnostic and prognostic markers, which can induce chemoresistance, and might indicate novel therapeutic targets for multiple myeloma. Targeting cyclic RNA therapy will bring spring to the treatment of multiple myeloma.","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127372965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In there has been much progress in developing more accurate thixo- lasto- visco-plastic rheological models that can be used to mechanically characterize human blood. In theory as the thixo-elasto-visco-plastic (TEVP) model accuracy and predictive capability improves, the parameterization, as well as insights and parametric correlations will also improve. This will allow researchers to determine the healthy, average values for each rheological parameter, as well as left and right limits (2-standard deviations in either direction from average) respectively. It is understood that the mechanical characterization can be vastly improved by using Series of Physical Process framework that can further explore the viscous (liquid-like) and elastic (solid-like) properties along with the TEVP model parameterization.
{"title":"Recent advancements to characterize human blood via thixo-visco-elasto-plastic modeling","authors":"M. Armstrong, Andre Pincot","doi":"10.46439/hematol.1.002","DOIUrl":"https://doi.org/10.46439/hematol.1.002","url":null,"abstract":"In there has been much progress in developing more accurate thixo- lasto- visco-plastic rheological models that can be used to mechanically characterize human blood. In theory as the thixo-elasto-visco-plastic (TEVP) model accuracy and predictive capability improves, the parameterization, as well as insights and parametric correlations will also improve. This will allow researchers to determine the healthy, average values for each rheological parameter, as well as left and right limits (2-standard deviations in either direction from average) respectively. It is understood that the mechanical characterization can be vastly improved by using Series of Physical Process framework that can further explore the viscous (liquid-like) and elastic (solid-like) properties along with the TEVP model parameterization.","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121239705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Anemia adversely affects the children mental, physical and social development, particularly in Africa. In the early stages of life, it leads to severe negative consequences on the cognitive as well as growth and development children. Objective: This study is aimed to assess the prevalence of anemia and its associated factors among under five children attending at Bule Hora General Hospital, Guji Zone, Southern Ethiopia, from October to November, 2020. Method: A hospital based quantitative cross-sectional study was conducted at Bule Hora General Hospital, Southern Ethiopia. Convenient sampling technique was used to include 375 under-five children enrolled in the study. The pretested structure questionnaire was used to collect socioeconomic and demographic characteristics of study individuals after taking appropriate written informed consent. Then venous blood sample was collected from each child and analyzed for hemoglobin determination using Cell-DYN 1800 machine. Binary logistic regression models were used to identify associated factors of anemia. P-value ≤ 0.05 was considered as statistically significant. Result: The overall prevalence of anemia among under-five children was 13.2 % (50) at [95% CI=5.2-21.2%] of them anemic children, 11.1% (1) were had mild, 33.3% (3) moderate 55.6% (5) is severe anemia. In this study anemia was significantly associated with history of intestinal protozoa infection [AOR=2.13, 95% CI=1.35-9.270], malaria infection [AOR=5.42, 95% CI=0.307-11.034] and soil-transmitted helminths infection [AOR=6.09, 95% CI=2.047-27.54]. Conclusion: Anemia among under-five children in this study was found to be mild public health problem. It could be managed through preventing malaria infection, intestinal protozoa and soil-transmitted helminthic infection. Feeding related factors: nutrition knowledge, food insecurity, dietary diversity practices, animal product (no eating meat), meal frequency, breastfeeding practice, and introduction complementary Health care and diseases characteristics: Acute blood loss, blood transfusion reaction, surgical procedure, recent history of accident, history of intestinal protozoan infections, history of malaria infection, epistaxis, history soil-transmitted helminthic infection and history chronic diseases.
{"title":"Prevalence of anemia and associated factors among Under-five children attended at Bule Hora general hospital, West Guji zone, Oromia region, Southern Ethiopia","authors":"Alqeer Aliyo, Abdurezak Jibril, Yonas Dessie","doi":"10.46439/hematol.1.003","DOIUrl":"https://doi.org/10.46439/hematol.1.003","url":null,"abstract":"Background: Anemia adversely affects the children mental, physical and social development, particularly in Africa. In the early stages of life, it leads to severe negative consequences on the cognitive as well as growth and development children. Objective: This study is aimed to assess the prevalence of anemia and its associated factors among under five children attending at Bule Hora General Hospital, Guji Zone, Southern Ethiopia, from October to November, 2020. Method: A hospital based quantitative cross-sectional study was conducted at Bule Hora General Hospital, Southern Ethiopia. Convenient sampling technique was used to include 375 under-five children enrolled in the study. The pretested structure questionnaire was used to collect socioeconomic and demographic characteristics of study individuals after taking appropriate written informed consent. Then venous blood sample was collected from each child and analyzed for hemoglobin determination using Cell-DYN 1800 machine. Binary logistic regression models were used to identify associated factors of anemia. P-value ≤ 0.05 was considered as statistically significant. Result: The overall prevalence of anemia among under-five children was 13.2 % (50) at [95% CI=5.2-21.2%] of them anemic children, 11.1% (1) were had mild, 33.3% (3) moderate 55.6% (5) is severe anemia. In this study anemia was significantly associated with history of intestinal protozoa infection [AOR=2.13, 95% CI=1.35-9.270], malaria infection [AOR=5.42, 95% CI=0.307-11.034] and soil-transmitted helminths infection [AOR=6.09, 95% CI=2.047-27.54]. Conclusion: Anemia among under-five children in this study was found to be mild public health problem. It could be managed through preventing malaria infection, intestinal protozoa and soil-transmitted helminthic infection. Feeding related factors: nutrition knowledge, food insecurity, dietary diversity practices, animal product (no eating meat), meal frequency, breastfeeding practice, and introduction complementary Health care and diseases characteristics: Acute blood loss, blood transfusion reaction, surgical procedure, recent history of accident, history of intestinal protozoan infections, history of malaria infection, epistaxis, history soil-transmitted helminthic infection and history chronic diseases.","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125432459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Activated phosphoinositide-3-kinase delta syndrome presenting with early onset (infantile) autoimmune thrombocytopenia","authors":"","doi":"10.46439/hematol.1.005","DOIUrl":"https://doi.org/10.46439/hematol.1.005","url":null,"abstract":"","PeriodicalId":320755,"journal":{"name":"Journal of Clinical and Experimental Hematology","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124961642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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