Pub Date : 2022-12-01DOI: 10.52418/moldovan-med-j.65-2.22.03
V. Cobzac, M. Jian, T. Globa, V. Nacu
Background: The existing surgical techniques used to regenerate articular cartilage fail. Utilisation of hierarchical, biphasic structures obtained from osteochondral tissue, through demineralisation, decellularization, longitudinal perforation and combination with chondroprogenitor cells, presents a high potential in cartilage defects regeneration. Material and methods: The research was performed on 36 rabbits, separated equally in two experimental and one control group. In the experimental groups, the experimental osteochondral defects of 4-4.5 mm in depth, were performed with a 3.7 drill bit at the level of weight bearing surface of the medial femoral condyle. In the 1st group the defects were treated with grafts combined with autologous chondrocytes, and in the 2nd group with grafts combined with autologous mesenchymal stem cells. In the control group, cartilaginous defects were treated by transferring the osteochondral plugs taken from the trochlear groove. The rabbits were removed from the experiment at 6 and 12 weeks. The results were evaluated by Unified Histological Score of Regenerated Cartilage (UHSRC). Results: At 6 weeks, according to UHSRC, the 1st group had 28.33±1.53 points, the 2nd group –27.67±2.08 points and the control group –26.33±1.53 points (p˃0.1; p˃0.2). At 12 weeks the 1st group had 18.68±5 points, the 2nd group –14.89±3.76 points and the control group –17.22 ±4.84 points (p˃0.5; p˃0.2). Conclusions: According to UHSRC, the experimental groups don’t show a significant difference compared to the control group at 6 and 12 weeks, also the quality of regenerated cartilage is poor.
{"title":"Joint cartilage experimental defect regeneration by hierarchic biphasic combined grafts","authors":"V. Cobzac, M. Jian, T. Globa, V. Nacu","doi":"10.52418/moldovan-med-j.65-2.22.03","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-2.22.03","url":null,"abstract":"Background: The existing surgical techniques used to regenerate articular cartilage fail. Utilisation of hierarchical, biphasic structures obtained from osteochondral tissue, through demineralisation, decellularization, longitudinal perforation and combination with chondroprogenitor cells, presents a high potential in cartilage defects regeneration. Material and methods: The research was performed on 36 rabbits, separated equally in two experimental and one control group. In the experimental groups, the experimental osteochondral defects of 4-4.5 mm in depth, were performed with a 3.7 drill bit at the level of weight bearing surface of the medial femoral condyle. In the 1st group the defects were treated with grafts combined with autologous chondrocytes, and in the 2nd group with grafts combined with autologous mesenchymal stem cells. In the control group, cartilaginous defects were treated by transferring the osteochondral plugs taken from the trochlear groove. The rabbits were removed from the experiment at 6 and 12 weeks. The results were evaluated by Unified Histological Score of Regenerated Cartilage (UHSRC). Results: At 6 weeks, according to UHSRC, the 1st group had 28.33±1.53 points, the 2nd group –27.67±2.08 points and the control group –26.33±1.53 points (p˃0.1; p˃0.2). At 12 weeks the 1st group had 18.68±5 points, the 2nd group –14.89±3.76 points and the control group –17.22 ±4.84 points (p˃0.5; p˃0.2). Conclusions: According to UHSRC, the experimental groups don’t show a significant difference compared to the control group at 6 and 12 weeks, also the quality of regenerated cartilage is poor.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43026442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.52418/moldovan-med-j.65-2.22.06
Anna Benea, C. Ciobanu, N. Ciobanu, I. Pompus, Maria Cojocaru-Toma
Background: Hyssopus officinalis L. (hyssop), a species native to the Caspian Sea region, has been cultivated in the Republic of Moldova as aromatic plant and has been used in folk medicine as antitussive, expectorant, carminative, digestive and sedative remedy. Material and methods: The aerial parts of H. officinalis L., with pink, white and blue flowers, were collected from the collection of the Scientific Practical Center in the Field of Medicinal Plants during flowering phase. The extracts were obtained with 70% ethanol by maceration with stirring. The concetration of the extracts was done with the rotative evaporator Laborota 4011. Identification of phenolic compounds in dried extracts from hyssop herb was carried out by thin-layer chromatography. The total content of hydrocyanamic acids was measured in plant products and dried ethanolic extracts, by spectrophotometric method, with Arnow’s reagent. Quantitative analysis of total phenolic content was carried out by UV-spectrophotometry analysis, using a Metertech UV/VIS SP 8001 spectrophotometer. Results: The chlorogenic (Rf 0.47) and caffeic (Rf 0.93) acids were identified in the three genotypes of Hyssop herba, with pink, white and blue flowers. The total of hydroxycinnamic acids, expressed in caffeic acid, for both, aerial parts and dry extract, was the highest in H. officinalis L. with white flowers (1.484 mg/g; 3.014 mg/g respectively), followed by H. officinalis L. with pink flowers (1.190 mg/g; 2.915 mg/g) and H. officinalis L. with blue flowers (1.015 mg/g; 2.851 mg/g). The highest polyphenol content, expressed in gallic acid equivalent (GAE), was found in the dry extract of H. officinalis L. with blue flowers (39.056 mgGAE/g dry extract). Conclusions: This study showed that the extract of the Hyssopus officinalis L. containing phenolic compounds, can be used as a natural antioxidant in pharmaceutical and cosmetic industries.
{"title":"Polyphenolic content and antioxidant activity of Hyssopus officinalis L. from the Republic of Moldova","authors":"Anna Benea, C. Ciobanu, N. Ciobanu, I. Pompus, Maria Cojocaru-Toma","doi":"10.52418/moldovan-med-j.65-2.22.06","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-2.22.06","url":null,"abstract":"Background: Hyssopus officinalis L. (hyssop), a species native to the Caspian Sea region, has been cultivated in the Republic of Moldova as aromatic plant and has been used in folk medicine as antitussive, expectorant, carminative, digestive and sedative remedy. Material and methods: The aerial parts of H. officinalis L., with pink, white and blue flowers, were collected from the collection of the Scientific Practical Center in the Field of Medicinal Plants during flowering phase. The extracts were obtained with 70% ethanol by maceration with stirring. The concetration of the extracts was done with the rotative evaporator Laborota 4011. Identification of phenolic compounds in dried extracts from hyssop herb was carried out by thin-layer chromatography. The total content of hydrocyanamic acids was measured in plant products and dried ethanolic extracts, by spectrophotometric method, with Arnow’s reagent. Quantitative analysis of total phenolic content was carried out by UV-spectrophotometry analysis, using a Metertech UV/VIS SP 8001 spectrophotometer. Results: The chlorogenic (Rf 0.47) and caffeic (Rf 0.93) acids were identified in the three genotypes of Hyssop herba, with pink, white and blue flowers. The total of hydroxycinnamic acids, expressed in caffeic acid, for both, aerial parts and dry extract, was the highest in H. officinalis L. with white flowers (1.484 mg/g; 3.014 mg/g respectively), followed by H. officinalis L. with pink flowers (1.190 mg/g; 2.915 mg/g) and H. officinalis L. with blue flowers (1.015 mg/g; 2.851 mg/g). The highest polyphenol content, expressed in gallic acid equivalent (GAE), was found in the dry extract of H. officinalis L. with blue flowers (39.056 mgGAE/g dry extract). Conclusions: This study showed that the extract of the Hyssopus officinalis L. containing phenolic compounds, can be used as a natural antioxidant in pharmaceutical and cosmetic industries.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44094202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.52418/moldovan-med-j.65-2.22.10
Tatiana Taralunga, A. Paduca, V. Nacu
Background: The tissue engineering is the evolving science that combines cells, biomaterials and biochemical factors aimed at restoring, maintaining and substituting different types of tissue. An important role is played by the use of the stem cells in various fields of medicine, including ophthalmology, namely in cases of retinopathies and optic nerve atrophy. Conclusions: Current treatment of the optic nerve atrophy is based on the etiological causes or late complications. Considering the availability of advanced therapies, stem cell therapy offers a new approach in the treatment of the atrophy of the optic nerve. Being easy to harvest and cultivate, mesenchymal stem cells are most commonly used in regenerative medicine, they can be induced to differentiate into cartilage, tendons, adipose tissue and other cell lines. Mesenchymal stem cell harvesting has no ethical issues compared to embryonic stem cell harvesting. The major histocompatibility factor II is not expressed on the surface of mesenchymal stem cells, and this great advantage allows their use in autologous or allogenic form. Mesenchymal stem cells produce growth factors with paracrine action that are thought to activate endogenous repair mechanisms, due to these properties mesenchymal stem cells have been used in several clinical studies in optic nerve disorders where immunomodulatory and neuroprotective properties have been demonstrated. All of the properties mentioned above stand for the clinical use of mesenchymal stem cells in case of optic nerve atrophy.
{"title":"A new approach to the treatment of retinopathies and optic nerve atrophy by using mesenchymal stem cells","authors":"Tatiana Taralunga, A. Paduca, V. Nacu","doi":"10.52418/moldovan-med-j.65-2.22.10","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-2.22.10","url":null,"abstract":"Background: The tissue engineering is the evolving science that combines cells, biomaterials and biochemical factors aimed at restoring, maintaining and substituting different types of tissue. An important role is played by the use of the stem cells in various fields of medicine, including ophthalmology, namely in cases of retinopathies and optic nerve atrophy. Conclusions: Current treatment of the optic nerve atrophy is based on the etiological causes or late complications. Considering the availability of advanced therapies, stem cell therapy offers a new approach in the treatment of the atrophy of the optic nerve. Being easy to harvest and cultivate, mesenchymal stem cells are most commonly used in regenerative medicine, they can be induced to differentiate into cartilage, tendons, adipose tissue and other cell lines. Mesenchymal stem cell harvesting has no ethical issues compared to embryonic stem cell harvesting. The major histocompatibility factor II is not expressed on the surface of mesenchymal stem cells, and this great advantage allows their use in autologous or allogenic form. Mesenchymal stem cells produce growth factors with paracrine action that are thought to activate endogenous repair mechanisms, due to these properties mesenchymal stem cells have been used in several clinical studies in optic nerve disorders where immunomodulatory and neuroprotective properties have been demonstrated. All of the properties mentioned above stand for the clinical use of mesenchymal stem cells in case of optic nerve atrophy.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48792406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.52418/moldovan-med-j.65-2.22.07
Chiril Voloc, Aliona Rotari, A. Voloc, E. Kuissi Kamgaing, J. F. Djoba Siawaya, S. Ategbo
Background: Vitamin D plays an important role in the prevention of many diseases. More than 1 billion people worldwide suffer from vitamin D deficiency. Vitamin D deficiency can contribute to the development of 16 types of cancer (breast, colon, prostate, etc.), cardiovascular diseases, stroke, autoimmune diseases, periodontal pathologies, transplant failure in endo-alveolar surgery, etc. There are several risk factors that would prevent the achievement of treatment objectives. The national protocol for deficiency rickets prevention privileges vitamin D2 versus vitamin D3, which creates a medical risk factor compromising oral health in both children and adults. The article provides sufficient arguments in favour of vitamin D3 vs vitamin D2 prescription for prophylactic and treatment purposes. Conclusions: Considering that vitamin D deficiency is currently a global public health problem, it can be proposed to declare vitamin D deficit/deficiency a priority public health problem at the national level. Vitamin D3 should be elective in preventing deficit. Taking into account the multitude of acute and chronic diseases related to vitamin D deficiency, in order to improve the status of vitamin D in all population categories, it is necessary to include vitamin D3 in the list of molecules fully subsidized by the state and distributed free of charge at least to children under the age of 5 years and adolescents in the period of intensive growth.
{"title":"Vitamin D2 versus vitamin D3 as a risk factor in compromised bone health","authors":"Chiril Voloc, Aliona Rotari, A. Voloc, E. Kuissi Kamgaing, J. F. Djoba Siawaya, S. Ategbo","doi":"10.52418/moldovan-med-j.65-2.22.07","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-2.22.07","url":null,"abstract":"Background: Vitamin D plays an important role in the prevention of many diseases. More than 1 billion people worldwide suffer from vitamin D deficiency. Vitamin D deficiency can contribute to the development of 16 types of cancer (breast, colon, prostate, etc.), cardiovascular diseases, stroke, autoimmune diseases, periodontal pathologies, transplant failure in endo-alveolar surgery, etc. There are several risk factors that would prevent the achievement of treatment objectives. The national protocol for deficiency rickets prevention privileges vitamin D2 versus vitamin D3, which creates a medical risk factor compromising oral health in both children and adults. The article provides sufficient arguments in favour of vitamin D3 vs vitamin D2 prescription for prophylactic and treatment purposes. Conclusions: Considering that vitamin D deficiency is currently a global public health problem, it can be proposed to declare vitamin D deficit/deficiency a priority public health problem at the national level. Vitamin D3 should be elective in preventing deficit. Taking into account the multitude of acute and chronic diseases related to vitamin D deficiency, in order to improve the status of vitamin D in all population categories, it is necessary to include vitamin D3 in the list of molecules fully subsidized by the state and distributed free of charge at least to children under the age of 5 years and adolescents in the period of intensive growth.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45443040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.52418/moldovan-med-j.65-1.22.08
Ilarion Draguta
Background: The infection with the new coronavirus SARS-CoV-2 has caused a large number of cases of disease and death worldwide. Identifying the source of COVID-19 is an important issue though still unresolved. The analysis of the literature on highlighting possible sources of the SARS-CoV-2 virus was carried out. Conclusions: The COVID-19 pandemic is occurring on the underlying imminent global ecological catastrophe as a result of the anthropogenic activity. Therefore, it can be stated that Homo Sapiens in the context of the interaction with the biosphere is a maladaptive species. According to the literature, the species’ adaptive responses to environmental changes are due to endogenous retroviruses. The latter act as evolutionary factors. Possible pandemic COVID-19 is not a separate epidemic process caused by the penetration of a new virus into human populations, but rather is one of the manifestations of a more complex natural phenomenon – an evolutionary process under the guise of an infectious one. In terms of evolution, COVID-19 plays the role of a biosphere factor that seeks to help a relatively new species to adapt to the general conditions of survival in a symbiotic relationship with other living organisms.
{"title":"Overview on possible causes of COVID-19","authors":"Ilarion Draguta","doi":"10.52418/moldovan-med-j.65-1.22.08","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-1.22.08","url":null,"abstract":"Background: The infection with the new coronavirus SARS-CoV-2 has caused a large number of cases of disease and death worldwide. Identifying the source of COVID-19 is an important issue though still unresolved. The analysis of the literature on highlighting possible sources of the SARS-CoV-2 virus was carried out. Conclusions: The COVID-19 pandemic is occurring on the underlying imminent global ecological catastrophe as a result of the anthropogenic activity. Therefore, it can be stated that Homo Sapiens in the context of the interaction with the biosphere is a maladaptive species. According to the literature, the species’ adaptive responses to environmental changes are due to endogenous retroviruses. The latter act as evolutionary factors. Possible pandemic COVID-19 is not a separate epidemic process caused by the penetration of a new virus into human populations, but rather is one of the manifestations of a more complex natural phenomenon – an evolutionary process under the guise of an infectious one. In terms of evolution, COVID-19 plays the role of a biosphere factor that seeks to help a relatively new species to adapt to the general conditions of survival in a symbiotic relationship with other living organisms.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48828324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.52418/moldovan-med-j.65-1.22.03
Victoria Verejan, E. Bendelic, J. Bernic
Background: Visual disturbances may result in a long-term complication after mild traumatic brain injury (mTBI) in children. These problems may affect both near work and reading, and thus affect activities of daily life and the child’s return to school activity. The purpose of the study was to assess the visual acuity disturbances and refractive status in children with persisting symptoms after mild traumatic brain injury. Material and methods: Forty-eight patients with persisting symptoms after mild traumatic brain injury and anomalies of visual acuity were included. Visual symptoms and refractive status were assessed during the eye examination. Results: Thus, in the mTBI group the visual acuity for the right eye was of 0.09-0.5 in 83.7% (40 patients), in 16.3% (8 patients) – right eye 0.6-0.8, comparing to the control group, where 62% patients had the visual acuity ranged almost in 1.0, just 14% (7 patients) ranged 0.09-0.5 and in 24% (12 patients) – 0.6-0.8. The visual acuity for the left eye in the research group was of 0.09-0.5 in 89.8% (43 patients), in 10.2% (5 patients) – for the left eye was 0.6-0.8, comparing to the control group, where 66% patients had the visual acuity ranged almost in 1.0, just 24% (12 patients) it ranged 0.09-0.5 and in 14% (5 patients) – 0.6-0.8. Conclusions: Visual acuity (VA) is affected primary after head trauma although it has big chances to get better with a vision therapy in a time period ranged between 3 and 6 months after the trauma. In most of the cases, we speak of a blurred vison in the near work and relative unclear perception at far. Autorefraction data usually will reveal a slight hyperopia with a possible astigmatic component ranged between 1D to 3D, and in 4.1%-8.2% of cases a slight myopia referring to the spherical compound and 18.4%-32.7% astigmatic compound, also ranged between 1D and 3D.
{"title":"Visual acuity disturbances following brain injury in school-aged children","authors":"Victoria Verejan, E. Bendelic, J. Bernic","doi":"10.52418/moldovan-med-j.65-1.22.03","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-1.22.03","url":null,"abstract":"Background: Visual disturbances may result in a long-term complication after mild traumatic brain injury (mTBI) in children. These problems may affect both near work and reading, and thus affect activities of daily life and the child’s return to school activity. The purpose of the study was to assess the visual acuity disturbances and refractive status in children with persisting symptoms after mild traumatic brain injury. Material and methods: Forty-eight patients with persisting symptoms after mild traumatic brain injury and anomalies of visual acuity were included. Visual symptoms and refractive status were assessed during the eye examination. Results: Thus, in the mTBI group the visual acuity for the right eye was of 0.09-0.5 in 83.7% (40 patients), in 16.3% (8 patients) – right eye 0.6-0.8, comparing to the control group, where 62% patients had the visual acuity ranged almost in 1.0, just 14% (7 patients) ranged 0.09-0.5 and in 24% (12 patients) – 0.6-0.8. The visual acuity for the left eye in the research group was of 0.09-0.5 in 89.8% (43 patients), in 10.2% (5 patients) – for the left eye was 0.6-0.8, comparing to the control group, where 66% patients had the visual acuity ranged almost in 1.0, just 24% (12 patients) it ranged 0.09-0.5 and in 14% (5 patients) – 0.6-0.8. Conclusions: Visual acuity (VA) is affected primary after head trauma although it has big chances to get better with a vision therapy in a time period ranged between 3 and 6 months after the trauma. In most of the cases, we speak of a blurred vison in the near work and relative unclear perception at far. Autorefraction data usually will reveal a slight hyperopia with a possible astigmatic component ranged between 1D to 3D, and in 4.1%-8.2% of cases a slight myopia referring to the spherical compound and 18.4%-32.7% astigmatic compound, also ranged between 1D and 3D.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44054437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.52418/moldovan-med-j.65-1.22.09
Stela Vudu, Gouri Durga Krishna
Background: Hypothyroidism is the deficiency in the production of thyroid hormones to meet the requirements of peripheral tissues. Subclinical hypothyroidism (SCH) is defined biochemically as normal serum free thyroxin concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration. SCH may be associated with low-grade systemic inflammation (increased high sensitivity-C reactive protein (hs-CRP), one possible explanation may be that TSH in adipocytes promotes the release of interleukin-6 (IL-6). Studies have confirmed inflammatory biomarkers like hs-CRP and IL-6 to be a predictor of cardiovascular (CV) events. However, the treatment of SCH remains subject to debate. Conclusions: It is increasingly evident that SCH has prognostic values and crucial clinical effects, which leads to the view of SCH not being a compensated biochemical change sensu strictu. Even a modest but consistent fluctuation in the circulating thyroid hormone levels can create a response from the human heart. Well-timed treatment should be considered as a precaution to avoid the unfavourable CV diseases. The inflammatory biomarkers, namely CRP and IL-6 are exceptionally robust markers of cardiovascular risk. Thus, using these biomarkers may be helpful in assessing the cardiovascular risk in patients with subclinical hypothyroidism.
{"title":"Low-grade systemic inflammation in subclinical hypothyroidism","authors":"Stela Vudu, Gouri Durga Krishna","doi":"10.52418/moldovan-med-j.65-1.22.09","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-1.22.09","url":null,"abstract":"Background: Hypothyroidism is the deficiency in the production of thyroid hormones to meet the requirements of peripheral tissues. Subclinical hypothyroidism (SCH) is defined biochemically as normal serum free thyroxin concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration. SCH may be associated with low-grade systemic inflammation (increased high sensitivity-C reactive protein (hs-CRP), one possible explanation may be that TSH in adipocytes promotes the release of interleukin-6 (IL-6). Studies have confirmed inflammatory biomarkers like hs-CRP and IL-6 to be a predictor of cardiovascular (CV) events. However, the treatment of SCH remains subject to debate. Conclusions: It is increasingly evident that SCH has prognostic values and crucial clinical effects, which leads to the view of SCH not being a compensated biochemical change sensu strictu. Even a modest but consistent fluctuation in the circulating thyroid hormone levels can create a response from the human heart. Well-timed treatment should be considered as a precaution to avoid the unfavourable CV diseases. The inflammatory biomarkers, namely CRP and IL-6 are exceptionally robust markers of cardiovascular risk. Thus, using these biomarkers may be helpful in assessing the cardiovascular risk in patients with subclinical hypothyroidism.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43689936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.52418/moldovan-med-j.65-1.22.02
Natalia Staver, I. Codreanu
Background: Evaluation of the peculiarities of radiology reports of patients with neoplasms of the abdomen and pelvis to optimize clinical imaging management. Material and methods: The study included 104 patients, divided into two groups, experimental group (L2) and control group (L1), repeatedly investigated by computed tomography in 2009-2019, a total of 440 examinations, of which 120 prospective examinations and 320 retrospective examinations, aged between 25 and 85 years, with primary tumors of the abdomen and pelvis. Results: Four specific descriptive criteria were analyzed from radiology reports and were obtained the following results: specification of the scanning protocols in radiology reports (0% for L1 and 95.3% for L2), specifying the reason for the examination in radiology reports (100% for L1 and 26.0% for L2), use of international terminology in radiology reports (0% for L1 and 74% for L2), patient follow-up in radiology reports (88.5% for L1 and 59.8 % for L2). Conclusions: Following the SWOT analysis of the radiology reports, has been developed a standardized model for describing CT images of patients with oncological pathologies of the abdomen and pelvis. The decision-making process was built on Strengths, eliminating Weaknesses, exploiting Opportunities and removing Threats.
{"title":"Audit of radiology reports of patients with neoplasms performed on computed tomography","authors":"Natalia Staver, I. Codreanu","doi":"10.52418/moldovan-med-j.65-1.22.02","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-1.22.02","url":null,"abstract":"Background: Evaluation of the peculiarities of radiology reports of patients with neoplasms of the abdomen and pelvis to optimize clinical imaging management. Material and methods: The study included 104 patients, divided into two groups, experimental group (L2) and control group (L1), repeatedly investigated by computed tomography in 2009-2019, a total of 440 examinations, of which 120 prospective examinations and 320 retrospective examinations, aged between 25 and 85 years, with primary tumors of the abdomen and pelvis. Results: Four specific descriptive criteria were analyzed from radiology reports and were obtained the following results: specification of the scanning protocols in radiology reports (0% for L1 and 95.3% for L2), specifying the reason for the examination in radiology reports (100% for L1 and 26.0% for L2), use of international terminology in radiology reports (0% for L1 and 74% for L2), patient follow-up in radiology reports (88.5% for L1 and 59.8 % for L2). Conclusions: Following the SWOT analysis of the radiology reports, has been developed a standardized model for describing CT images of patients with oncological pathologies of the abdomen and pelvis. The decision-making process was built on Strengths, eliminating Weaknesses, exploiting Opportunities and removing Threats.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46947856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.52418/moldovan-med-j.65-1.22.05
Andrei Scureac, Serghei Cumpata, E. Gutu
Background: Gastroesophageal reflux disease (GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. The patient who does not respond to the empiric antisecretory treatment, with alarming symptoms, or referred to surgery should undergo an esophagogastroduodenoscopy (EGD). Material and methods: This was a retrospective and descriptive study of patients with GERD admitted for antireflux laparoscopic surgery from 2012 to 2019. All endoscopic data were analyzed with the following variables: age, gender, reflux esophagitis and its severity, esophageal ulcers and strictures, Shatzky’s ring, Barrett’s esophagus (BE), incompetence of the esogastric junction; hiatal hernia. Results: A total of 152 patients were included in the study. The age of the patients ranged from 19 to 76 years, averaging 52 years. Among them, 97 (63.8%) were women and 55 (35.38%) men. A wide variety of endoscopic features has been found: non-erosive GERD (6.57%); reflux esophagitis (Savary-Miller) – I (21.05%), II (44.07%), III (23.68%); esophageal ulcer (1.31%), BE (1.97%). The majority of patients present axial hiatal hernia (92.76%) corresponding to Hill grade IV incompetence of the flap valve. Hill grade III was present in 4.6% of cases, grade II – 2.63%. Conclusions: The patients with GERD may have a wide range of endoscopic features (from normal to esophagitis, hiatal hernia, strictures and EB). Considering the multitude of data provided by endoscopic examination in patients with GERD, it can be certainly stated that EGD is one of the most important investigations in these patients, and is mandatory in those selected for surgical treatment.
{"title":"Endoscopic findings in patients with gastroesophageal reflux disease referred to antireflux laparoscopic surgery","authors":"Andrei Scureac, Serghei Cumpata, E. Gutu","doi":"10.52418/moldovan-med-j.65-1.22.05","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-1.22.05","url":null,"abstract":"Background: Gastroesophageal reflux disease (GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. The patient who does not respond to the empiric antisecretory treatment, with alarming symptoms, or referred to surgery should undergo an esophagogastroduodenoscopy (EGD). Material and methods: This was a retrospective and descriptive study of patients with GERD admitted for antireflux laparoscopic surgery from 2012 to 2019. All endoscopic data were analyzed with the following variables: age, gender, reflux esophagitis and its severity, esophageal ulcers and strictures, Shatzky’s ring, Barrett’s esophagus (BE), incompetence of the esogastric junction; hiatal hernia. Results: A total of 152 patients were included in the study. The age of the patients ranged from 19 to 76 years, averaging 52 years. Among them, 97 (63.8%) were women and 55 (35.38%) men. A wide variety of endoscopic features has been found: non-erosive GERD (6.57%); reflux esophagitis (Savary-Miller) – I (21.05%), II (44.07%), III (23.68%); esophageal ulcer (1.31%), BE (1.97%). The majority of patients present axial hiatal hernia (92.76%) corresponding to Hill grade IV incompetence of the flap valve. Hill grade III was present in 4.6% of cases, grade II – 2.63%. Conclusions: The patients with GERD may have a wide range of endoscopic features (from normal to esophagitis, hiatal hernia, strictures and EB). Considering the multitude of data provided by endoscopic examination in patients with GERD, it can be certainly stated that EGD is one of the most important investigations in these patients, and is mandatory in those selected for surgical treatment.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48635021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.52418/moldovan-med-j.65-1.22.06
Victor Schiopu, Corina Scerbatiuc-Condur, Nicolae Ghidirim
Background: Primary retroperitoneal tumors (PRT) are a group of extremely heterogeneous soft tissue tumors that grow in the retroperitoneal space and have no organic affiliation. Tumors usually become symptomatically late and cause secondary symptoms or become palpable once they have become significantly large. Preoperative diagnosis of PRT is essential for assessing subsequent treatment tactics, planning the approach and volume of surgery, by detecting the structural component, relationships with adjacent anatomical structures and the degree of invasion. Material and methods: Complex prospective and retrospective analysis of clinical, anamnestic and imaging data of 118 patients with primary and nonprimary retroperitoneal tumors, investigated and treated at the Institute of Oncology of the Republic of Moldova during 2015-2020. Results: To determine the primary PRT diagnosis for the clinician, it is primordial to rule out the organic or secondary nature of the tumor. Thus, the patients were examined by: abdominal USG – 118 patients (100%), abdominal and small pelvic contrast-enhanced CT – 118 patients (100%), MRI – 3 patients (2.5%), videoesogastroduodenoscopy – 32 patients (27.1%), videocolonoscopy – 31 patients (26.3%), irigography – 4 patients (3.4%), urography – 29 patients (24.6%). Conclusions: Contrast-enhanced CT provides more accurate data than USG. The image obtained at the USG examination is flat, therefore the dimensional measurements of the tumor are not always performed on the longest tumor axis, especially in the case of polylobulated or giant tumors, while the tomographic examination techniques allow the three-dimensional reconstruction of the tumor with more accurate assessment of the tumor size.
{"title":"Comparative analysis of imaging investigations in the diagnosis of retroperitoneal tumors","authors":"Victor Schiopu, Corina Scerbatiuc-Condur, Nicolae Ghidirim","doi":"10.52418/moldovan-med-j.65-1.22.06","DOIUrl":"https://doi.org/10.52418/moldovan-med-j.65-1.22.06","url":null,"abstract":"Background: Primary retroperitoneal tumors (PRT) are a group of extremely heterogeneous soft tissue tumors that grow in the retroperitoneal space and have no organic affiliation. Tumors usually become symptomatically late and cause secondary symptoms or become palpable once they have become significantly large. Preoperative diagnosis of PRT is essential for assessing subsequent treatment tactics, planning the approach and volume of surgery, by detecting the structural component, relationships with adjacent anatomical structures and the degree of invasion. Material and methods: Complex prospective and retrospective analysis of clinical, anamnestic and imaging data of 118 patients with primary and nonprimary retroperitoneal tumors, investigated and treated at the Institute of Oncology of the Republic of Moldova during 2015-2020. Results: To determine the primary PRT diagnosis for the clinician, it is primordial to rule out the organic or secondary nature of the tumor. Thus, the patients were examined by: abdominal USG – 118 patients (100%), abdominal and small pelvic contrast-enhanced CT – 118 patients (100%), MRI – 3 patients (2.5%), videoesogastroduodenoscopy – 32 patients (27.1%), videocolonoscopy – 31 patients (26.3%), irigography – 4 patients (3.4%), urography – 29 patients (24.6%). Conclusions: Contrast-enhanced CT provides more accurate data than USG. The image obtained at the USG examination is flat, therefore the dimensional measurements of the tumor are not always performed on the longest tumor axis, especially in the case of polylobulated or giant tumors, while the tomographic examination techniques allow the three-dimensional reconstruction of the tumor with more accurate assessment of the tumor size.","PeriodicalId":32733,"journal":{"name":"The Moldovan Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44692434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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