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Expression of Kl67 In ER+ PR+ HER2- & ERr- PRr- HER2- Breast Cancer Patients Kl67在ER+ PR+ HER2-和ERr- PRr- HER2-乳腺癌患者中的表达
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43812
Hasanuzzaman, Johirul Lslam, A. Hossain, Rassell, M. M. Rahman, M. Rahman, A. U. Haque
Background: Carcinoma of the breast is one of the most common malignancies in women worldwide. Objective: The current study was conducted to evaluate the role of Ki-67 as a prognosticmarker in two definite groups of breast cancer patients (ER+ve, PR+ve, HER-ve& triple negative)in Bangladesh perspective. Methods: Sixty nine female breast cancer patients operated at the surgical oncology departmentof National Institute of Cancer Research & Hospital were selected by non-probabilitysampling method and operated specimens were sent for immunohistochemical study of theER, PR, Her2/neu receptors and Ki-67 protein analysis. Statistical analysis was conductedusing SPSS version 17 for Windows software. P-value 0.05 or less was considered as significant. Result: The mean age of the patients was 46.96 years with SD of± 13.13 years. Histopathologyreports revealed that 94.2% (65/69) were suffering from duct cell carcinoma (DCC) whilelobular varieties were found in 2 cases. Majority of the patients with ER+, PR+ and Ki-67 +vestatus were between 36-50 years of age. But for Her2/neu positive cases most of patientswere above 50 years of age. In Luminal A category cancer patients 69.7% showed positiveKi-67 expression but in case of triple negative cases this percentage was 87.5%. However, thisdifference was not statistically significant. Conclusion: Scores based upon staining of ER, PR, Her2/neu and Ki-67 collectively known asIHC4 which can be used as prognostic markers in breast cancer patients. Journal of Surgical Sciences (2016) Vol. 20 (2) :37-41
背景:乳腺癌是全世界女性最常见的恶性肿瘤之一。目的:本研究旨在评估Ki-67在孟加拉国两组乳腺癌患者(ER+ve、PR+ve、her -ve和三阴性)中的预后指标作用。方法:采用非概率抽样方法,选取在国立肿瘤研究所肿瘤外科手术的女性乳腺癌患者69例,将手术标本送行er、PR、Her2/neu受体和Ki-67蛋白的免疫组化检测。采用SPSS version 17 for Windows软件进行统计分析。p值小于0.05为显著性。结果:患者平均年龄46.96岁,SD±13.13岁。组织病理学报告显示94.2%(65/69)为导管细胞癌(DCC), 2例为小叶细胞癌。ER+、PR+和Ki-67 +vestatus患者以36-50岁为主。但在Her2/neu阳性病例中,大多数患者年龄在50岁以上。在Luminal A类肿瘤患者中,69.7%的患者ki -67阳性表达,而在三阴性病例中,这一比例为87.5%。然而,这种差异没有统计学意义。结论:基于ER、PR、Her2/neu和Ki-67(统称asIHC4)染色的评分可作为乳腺癌患者的预后指标。外科杂志(2016)Vol. 20 (2):37-41
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引用次数: 0
Dence of Postoperatve Deep Vein Thrombosis:A Study of 150 Cases 150例术后深静脉血栓的预防分析
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43813
M. A. Sarker, A. Amin, Johirul Lslam, A. Nuruzzaman, A. Bhattacharjee
Background: Venous thromboembolism remains a common cause of morbidity and sometimescause of death in surgical practice. In developed world about 10% of hospital deathsare due to pulmonary embolism resulting from deep vein thrombosis( DVT). DVT in Asiancountries is not a rare condition. Objective: The purpose of the study was to find the incidence ,demgraophic characterand risk factors of deep vein thrombosis. Methods: 150patients undergoing emergency or elective operation of more than one hourof duration was selected for study. Patients evaluated by history, clinical examination andduplex scan. Collected analyzed by computer program. Results: 102 cases were male and 48 cases were female. The incidence of DVT in malewas 36.3% while among females it was 27.5%. venous thrombosis in age group above 50yrs is quite high, (43.33%) . One-fifth of the DVT patients were smokers. Longer duration ofoperation procedure was correlated with development of DVT and development of DVT waslittle higher in emergency operation than elective one. The occurrence of the condition insome co-morbid states especially diabetes mellitus (36. 7%) and cancer (33.3%) is noteworthy.Out of 51 DVT patients more than 84% developed sub-clinical DVT. Conclusion: In Bangladesh it is assumed that DVT is rare. But the current study revealsthat the incidence of postoperative DVT in Bangladesh is not that much rare event. Journal of Surgical Sciences (2016) Vol. 20 (2) :42-45
背景:静脉血栓栓塞仍然是外科实践中常见的发病原因,有时甚至导致死亡。在发达国家,约10%的医院死亡是由于深静脉血栓形成(DVT)引起的肺栓塞。深静脉血栓在亚洲国家并不罕见。目的:了解深静脉血栓形成的发生率、人口学特征及危险因素。方法:选取150例急诊或择期手术时间大于1小时的患者作为研究对象。通过病史、临床检查和双相扫描对患者进行评估。通过计算机程序收集分析。结果:男性102例,女性48例。男性深静脉血栓发生率为36.3%,女性为27.5%。50岁以上年龄组静脉血栓发生率较高,占43.33%。五分之一的深静脉血栓患者是吸烟者。手术时间较长与DVT的发生相关,急诊手术DVT的发生略高于择期手术。在一些合并症中,特别是糖尿病中,这种情况的发生(36)。7%)和癌症(33.3%)值得注意。在51例深静脉血栓患者中,超过84%的患者发展为亚临床深静脉血栓。结论:在孟加拉国,人们认为深静脉血栓是罕见的。但目前的研究表明,在孟加拉国,术后深静脉血栓的发生率并不是那么罕见。外科杂志(2016)Vol. 20 (2):42-45
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引用次数: 0
Pica of Adult Onset Presenting as Surgical Emergency 成人异食癖以外科急诊的形式出现
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43818
Azizur Rahman, Abu Taher Md Ashaduzzaman, A. Jamal, Abm Bayzid Hossain, S. Paul, T. Saha, H. Saha
Pica is a worldwide problem that has no barriers of age, race, gender or geography. Picamay be benign or it may have life threatening consequences. We report here a case of 28-year-old male, electrician apparently psychologically sound got admitted with complaints ofpersistent pain in upper abdomen and vomiting with history of ingestion of dinner fork andtooth brush. Laparotomy was done to remove the foreign bodies and later referred topsychiatry department where he was diagnosed as an adult onset pica due to schizophrenia.Pica in elderly age group is relatively uncommon, and it rarely has an adult onset. Journal of Surgical Sciences (2016) Vol. 20 (2) :62-64
异食癖是一个世界性的问题,没有年龄、种族、性别或地域的障碍。皮卡可能是良性的,也可能有危及生命的后果。我们在此报告一例28岁男性电工,心理健康,因持续上腹疼痛和呕吐而入院,并有进食餐叉和牙刷的历史。开腹手术取出异物,随后转介精神科,诊断为因精神分裂症引起的成人异食癖。异食癖在老年人群中相对少见,很少有成人发病。外科杂志(2016)Vol. 20 (2):62-64
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引用次数: 0
Gastro Intestinal Stromal Tumour: Treatment Strategies 胃肠道间质瘤:治疗策略
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43817
Masrur A. Khan
Recent discoveries over the last decade have led to a greater insight to the molecular and biologicalbehavior of GIST along with its expression of receptors like KIT and platelet derived growthfactor. Consequently the advent of the tyrosine kinase inhibitor imatinibmesylate has been aphenomenal example of targeted molecular therapy. The unique success of the targeted therapyin the management of GIST has enhanced the multidisciplinary management approach to thedisease. Careful and intense study of the treatment strategies in GIST may lead to new era in themanagement of cancer. Journal of Surgical Sciences (2016) Vol. 20 (2) :55-58
在过去的十年中,最近的发现使人们对GIST的分子和生物学行为及其受体如KIT和血小板衍生生长因子的表达有了更深入的了解。因此,酪氨酸激酶抑制剂伊马替尼甲磺酸的出现是靶向分子治疗的一个非凡的例子。靶向治疗在胃肠道间质瘤管理中的独特成功,加强了对该疾病的多学科管理方法。对胃肠道间质瘤治疗策略的深入研究可能会开启肿瘤治疗的新纪元。外科杂志(2016)Vol. 20 (2):55-58
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引用次数: 1
Gastrointestinal Perforation Due to Gastrointestinal Stromal Tumour (GIST) In Small Intestine-A Case Report 小肠间质瘤致胃肠道穿孔1例报告
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43819
Sm Sagar, A. Sharfuzzaman, SM Nazrul Lslam, M. Hasan
Gastrointestinal stromal tumors (GISTs) is a mesenchymal tumor of GI tract. Now a daysdiagnosis of GISTs is more frequent then previous due to advance diagnostic tool. GISTsusually present with abdominal mass and GI bleeding but it may also present with manyunusual pattern like obstruction, perforation. Perforation of GISTs is extremely rare presentation.We report a case of pneumoperitoneum due to perforation of small intestinal GIST.Emergency laparotomy followed by resection and end to end anastomosis was done. Aftersurgical treatment lmatinibmesylate was given for prevention of early recurrence. Journal of Surgical Sciences (2016) Vol. 20 (2) :65-67
胃肠道间质瘤是一种发生在胃肠道的间质肿瘤。现在由于先进的诊断工具,胃肠道间质瘤的诊断比以前更频繁。它通常表现为腹部肿块和消化道出血,但也可能出现许多不寻常的症状,如梗阻、穿孔。胃肠道间质瘤穿孔是极为罕见的表现。我们报告一例因小肠间质瘤穿孔而致气腹的病例。急诊开腹手术,术后切除,端端吻合。术后给予伊马替尼甲磺酸预防早期复发。外科杂志(2016)Vol. 20 (2):65-67
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引用次数: 4
Prognostic Factors of Success of Extracorporeal Shock Wave Lithotripsy 46 (ESWL) in The Treatment of Renal Stones. 体外冲击波碎石术治疗肾结石成功的预后因素分析。
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43814
M. A. Zaman, Jamal E Rabby, M. Ali, Kabirul Hassan, M. M. Rahman, Atm Ashaduzzaman
Background: Renal calculi are common approximately 50% of patient between the ages of 30and 50 years. The development of endourological and extracorporeal lithotripsy techniques ledto an increasing number of options for the management of renal calculi. Objective: To define factors those have a significant impact on the success rate after extracorporealshock wave lithotripsy (ESWL) for treatment of renal stones. Materials and Methods: Between April 2008 & December 2008, 64 patients with single ormultiple radiopaque renal stones (::s;30mm) were treated with ESWL monotherapy using StortzModulith SLX-F2 lithotriptor.The results of treatment were evaluated after 3 months of followupTreatment success was defined as complete clearance of the stones or presence ofclinically insignificant residual fragments (::s;4mm).The results of treatment were correlated withthe patient characteristics (age, sex, body mass index) and stone features (size, site, nature &radio density). Results: At 3-months follow-up, the overall success rate is 76%. Among them, repeated ESWLsessions are required in 19 patients (53.9%). Post-ESWL complications are recorded in 8patients (12.5%). Using the x2 test, only three factors have a significant impact on the successrate, namely: stone site, size (the largest diameter of the stone), stone number & BMI (BodyMass Index). The success rate is highest for stones located in the upper calyx (15/15; 100%)and lowest for those located in the lower calyx (10/16; 62.5%) (p=.005). Stones with a largestdiameter ot s 15mm are associated with a success rate of 90.2% (37 /41), compared to 52.2%(12/23) for those with a diameter of >15mm (p=.001). The success rate is also higher forsingle stone (46/56; 82%) than multiple stones (3/8; 37.5%) (p=0.005).Patients with lowerBMI (<24) have a better success than higher BMI (>25) (p=0.01) Conclusion: The success rate of ESWL for the treatment of renal stones can be predicted bystone size, location, number and patient BMI. Journal of Surgical Sciences (2016) Vol. 20 (2) :46-50
背景:肾结石很常见,大约50%的患者年龄在30 - 50岁之间。随着泌尿系统和体外碎石技术的发展,治疗肾结石的方法越来越多。目的:探讨影响体外冲击波碎石(ESWL)治疗肾结石成功率的因素。材料与方法:2008年4月至2008年12月间,采用StortzModulith SLX-F2碎石机对64例单发或多发透光性肾结石(::5;30mm)进行ESWL单药治疗。治疗结果在随访3个月后进行评估,治疗成功的定义是结石完全清除或存在临床不显著的残余碎片(::5;4mm)。治疗结果与患者特征(年龄、性别、体重指数)和结石特征(大小、部位、性质和放射性密度)相关。结果:随访3个月,总成功率为76%。其中19例(53.9%)患者需要重复eswlsession。eswl术后并发症8例(12.5%)。通过x2检验,只有三个因素对成功率有显著影响,分别是:结石部位、大小(结石的最大直径)、结石数量和BMI(身体质量指数)。位于花萼上部的结石成功率最高(15/15;100%),位于下花萼的最低(10/16;62.5%) (p = .005)。直径大于15毫米的结石成功率为90.2%(37 /41),而直径大于15毫米的结石成功率为52.2%(12/23)(p=.001)。单个结石的成功率也更高(46/56;82%)大于多发结石(3/8;37.5%) (p = 0.005)。结论:ESWL治疗肾结石的成功率可通过结石的大小、位置、数量和患者的BMI来预测。外科杂志(2016)Vol. 20 (2):46-50
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引用次数: 0
Case Report Adrenal Myelolipoma 肾上腺骨髓瘤病例报告
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43816
Abu Taher Md Ashaduzzaman, M. Khalil, Abm Jarnaf
Adrenal myelolipoma is a rare tumor that is benign in nature, usually asymptomatic, unilateraland nonsecreting, With the widespread use of imaging modalities such as ultrasonographythe incidental detection of these tumors are increasing in frequency. We report acase of adrenal myelolipoma in a 45-year-old female who presented with pain in the rightupper abdomen, headache and hypertension. Myelolipoma as an incidental diagnosismight keep in mind and evaluate accordingly to validated protocol because of surgicalemergencies such as spontaneous retroperitoneal hemorrhage. Journal of Surgical Sciences (2016) Vol. 20 (2) :59-61
肾上腺骨髓瘤是一种罕见的良性肿瘤,通常无症状、单侧、无分泌性。随着超声等影像学手段的广泛应用,偶然发现这些肿瘤的频率越来越高。我们报告一例肾上腺骨髓瘤在一个45岁的女性谁提出了疼痛在右上腹部,头痛和高血压。由于手术紧急情况,如自发性腹膜后出血,作为偶然诊断的骨髓瘤应记住并根据有效的方案进行评估。外科杂志(2016)Vol. 20 (2):59-61
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引用次数: 0
Bile Duct Injury during Laparoscopic Cholecystectomy: Risk Factors, Mechanism and Prevention 腹腔镜胆囊切除术中胆管损伤:危险因素、机制及预防
Pub Date : 2019-11-07 DOI: 10.3329/jss.v20i2.43811
A. Akbar
Abstract not available Journal of Surgical Sciences (2016) Vol. 20 (2) :35-36
外科科学杂志(2016)Vol. 20 (2):35-36
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引用次数: 0
A short history of surgery and anesthesiology in Space 太空手术和麻醉学的简史
Pub Date : 2019-11-06 DOI: 10.33695/jss.v6i3.268
Christos Tsagkaris
Space Medicine has grown in parallel to Space Exploration since the second half of the 20th century. Surgery and anesthesia procedures with a special focus on acute surgical conditions management have been investigated and/or performed on animal models and astronauts/cosmonauts. Although total anesthesia has been successfully performed on animal models it is considered of high risk for humans and regional anesthesia techniques have been the method of choice so far. The history of surgery and anesthesia in Space has expanded the limits of these fields and is expected to skyrocket their conjugation with modern technology such as 3D printing.  
自20世纪下半叶以来,太空医学与太空探索同步发展。在动物模型和宇航员身上研究和/或进行了外科手术和麻醉程序,特别关注急性手术条件的管理。虽然在动物模型上已经成功地进行了全麻醉,但它被认为对人类有高风险,迄今为止,区域麻醉技术一直是选择的方法。太空手术和麻醉的历史扩大了这些领域的局限性,预计将与3D打印等现代技术结合起来。
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引用次数: 1
Surgical Management Analysis of Emergency Colorectal Cancer Surgical Cases - a Retrospective Observational Study 急诊结直肠癌手术病例的外科处理分析——回顾性观察研究
Pub Date : 2019-11-06 DOI: 10.33695/jss.v6i3.276
G. Andrei, B. Dumitriu, M. Beuran
We present an observational retrospective study which takes into consideration and analyzes the surgical management of emergency colorectal cancer cases. This analysis would contribute to a better understanding and for identification of those characteristics that are essential for reducing emergency colorectal cancer incidence and for improving the management of such cases. A number of 159 patients that underwent surgery for obstructive, bleeding or perforated colorectal cancer between January 2015 and September 2017 were selected to be included in the study. The results obtained by analyzing available data collected from the observation charts, surgery protocols, histopathological protocols were then compared with those in the literature.
我们提出了一项观察性回顾性研究,考虑并分析了急诊结直肠癌病例的手术治疗。这一分析将有助于更好地了解和确定那些对减少紧急结直肠癌发病率和改善这类病例的管理至关重要的特征。2015年1月至2017年9月期间接受手术治疗梗阻性、出血或穿孔结直肠癌的159例患者被纳入研究。通过分析从观察图、手术方案、组织病理学方案中收集的可用数据获得的结果,然后与文献中的结果进行比较。
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引用次数: 0
期刊
Journal of Surgical Sciences
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