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2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)最新文献

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Intelligent fractional-order PID (FOPID) heart rate controller for cardiac pacemaker 智能分数阶PID (FOPID)心脏起搏器心率控制器
Pub Date : 2016-12-27 DOI: 10.1109/HIC.2016.7797708
S. P. Arunachalam, S. Kapa, S. Mulpuru, P. Friedman, E. Tolkacheva
Efficient and robust control of cardiac pacemaker is essential for providing life-saving control action to regulate Heart Rate (HR) in a dynamic environment. Several controller designs involving proportional-integral-derivative (PID) and fuzzy logic controllers (FLC) have been reported but each have their limitations to face the dynamic challenge of regulating HR. Fractional-order control (FOC) systems provide controllers that are described by fractional-order differential equations that offers fine tuning of the control parameters to provide robust and efficient performance. In this work a robust fractional-order PID (FOPID) controller is designed based on Ziegler-Nichols tuning method. The stable FOPID controller outperformed PID controllers with different tuning methods and also the FLC in terms of rise time, settling time and % overshoot. The FOPID controller also demonstrated feasibility for rate-adaptive pacing. However, the FOPID controller designed in this work is not optimal and is limited by the tuning procedure. More efficient design using optimization techniques such as particle swarm intelligence or genetic algorithm tuning can offer optimal control of the cardiac pacemaker.
有效和稳健的心脏起搏器控制对于在动态环境中提供挽救生命的控制行动来调节心率(HR)至关重要。比例-积分-导数(PID)和模糊逻辑控制器(FLC)等几种控制器设计已经被报道,但它们在面对调节HR的动态挑战时都有其局限性。分数阶控制(FOC)系统提供由分数阶微分方程描述的控制器,可以对控制参数进行微调,以提供鲁棒和高效的性能。本文基于齐格勒-尼科尔斯整定方法设计了一种鲁棒分数阶PID控制器。稳定的FOPID控制器在上升时间、稳定时间和超调率方面优于采用不同整定方法的PID控制器,也优于FLC控制器。FOPID控制器也证明了速率自适应起搏的可行性。然而,本文所设计的FOPID控制器并不是最优的,并且受到整定过程的限制。更有效的设计使用优化技术,如粒子群智能或遗传算法调谐可以提供心脏起搏器的最佳控制。
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引用次数: 16
Comparing machine learning clustering with latent class analysis on cancer symptoms' data 机器学习聚类与潜在类分析对癌症症状数据的比较
Pub Date : 2016-11-09 DOI: 10.1109/HIC.2016.7797722
Nikolaos Papachristou, C. Miaskowski, P. Barnaghi, R. Maguire, Nazli Farajidavar, B. Cooper, Xiao Hu
Symptom Cluster Research is a major topic in Cancer Symptom Science. In spite of the several statistical and clinical approaches in this domain, there is not a consensus on which method performs better. Identifying a generally accepted analytical method is important in order to be able to utilize and process all the available data. In this paper we report a secondary analysis on cancer symptom data, comparing the performance of five Machine Learning (ML) clustering algorithms in doing so. Based on how well they separate specific subsets of symptom measurements we select the best of them and proceed to compare its performance with the Latent Class Analysis (LCA) method. This analysis is a part of an ongoing study for identifying suitable Machine Learning algorithms to analyse and predict cancer symptoms in cancer treatment.
症状聚类研究是癌症症状科学的一个重要课题。尽管在这一领域有几种统计和临床方法,但对于哪种方法表现更好还没有达成共识。为了能够利用和处理所有可用的数据,确定一种普遍接受的分析方法是很重要的。在本文中,我们报告了对癌症症状数据的二次分析,比较了五种机器学习(ML)聚类算法在此过程中的性能。基于它们如何很好地分离症状测量的特定子集,我们选择其中最好的,并继续将其性能与潜在类分析(LCA)方法进行比较。这项分析是一项正在进行的研究的一部分,该研究旨在确定合适的机器学习算法,以分析和预测癌症治疗中的癌症症状。
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引用次数: 14
Two-dimensional, error-corrected barcode readout for point-of-care colorimetrie assays 二维,纠错条形码读出点护理比色测定
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797702
Harrison Hall, Abeer Syed, John X. J. Zhang
We report a semiquantitative readout technique using structured Quick Response (QR) codes partially patterned with colorimetric assay. This allows error-corrected readout at point-of-care (POC) the assay using mobile devices while transparently enabling remote tabulation of population-level statistics through analysis of web traffic.
我们报告了一种半定量读出技术,使用结构化快速反应(QR)代码,部分图案与比色分析。这允许使用移动设备在医疗点(POC)进行校正错误的读数,同时通过分析网络流量透明地实现人口水平统计的远程制表。
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引用次数: 1
Technology platform for tele-rehabilitation implementation in Mysathenia gravis at the point-of-care 在护理点实现重症肌无力远程康复的技术平台
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797694
C. Hafer-Macko, J. Naumes, R. Macko, A. Roy
Myasthenia gravis (MG) is a rare neuromuscular condition characterized by weakness and fatigue. Exertional fatigue in MG provokes caution with exercise advice. There is no consensus on how to implement safe and effective exercise or rehabilitation for MG. To address this gap, we developed an MG specific, progressive exercise program that focuses on the muscles that are most affected. The program combines aerobic training, muscular endurance, and pulmonary rehabilitation to improve function, energy efficiency, and cardio-pulmonary capacity. Our Interactive Video Exercise Tele-rehabilitation (IVET) platform embeds our MG specific exercises, adapted to each client's capacity. A video avatar guides home exercises with adjustable metronome pacing, while video capturing the client's performance for unprecedented understanding of desired body mechanics and to enhance coach feedback. This two-way interactive wireless platform increases access to expert oversight and enhances safety. IVET was pilot tested at the point-of-care in neurology and infusion clinics to assess clients' acceptance of this technology, as well as client and coach/therapist ratings on client safety and competency for each exercise. Twelve clients with a broad range of age and MG severity were enrolled. Survey of client's technology acceptance for home IVET exercise used a nominal 10-point scale and demonstrated high rating for enjoyment, interest, confidence, safety, perceived value, and increased frequency of structured exercise. Further studies are needed to determine the treatment fidelity, safety, and efficacy of IVET as a virtual therapist in the home to improve function and health for individuals with MG.
重症肌无力(MG)是一种罕见的神经肌肉疾病,以虚弱和疲劳为特征。MG的劳累性疲劳引起了运动建议的谨慎。对于如何安全有效地进行MG的锻炼和康复,目前还没有达成共识。为了解决这一差距,我们开发了一种针对MG的渐进式锻炼计划,重点关注受影响最大的肌肉。该项目结合了有氧训练、肌肉耐力和肺部康复来改善功能、能量效率和心肺容量。我们的交互式视频练习远程康复(IVET)平台嵌入了MG特定的练习,以适应每个客户的能力。视频化身指导家庭练习与可调节拍器节奏,而视频捕捉客户的表现前所未有的理解所需的身体力学和加强教练的反馈。这种双向互动无线平台增加了专家监督的机会,并提高了安全性。IVET在神经病学和输液诊所的护理点进行了试点测试,以评估客户对这项技术的接受程度,以及客户和教练/治疗师对客户安全性和每次练习能力的评分。纳入了12名年龄和MG严重程度不等的患者。客户对家庭IVET锻炼的技术接受度调查使用了名义10分制,并在享受、兴趣、信心、安全、感知价值和结构化锻炼频率增加方面显示出较高的评级。需要进一步的研究来确定IVET作为家庭虚拟治疗师改善MG患者的功能和健康的治疗保真度、安全性和有效性。
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引用次数: 1
An Android based wireless ECG monitoring system for cardiac arrhythmia 基于Android的心律失常无线心电监测系统
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797727
Varsha Wahane, P. Ingole
The Wireless Body Area Network (WBAN) is emerging by leaps and bound due to tremendous evolutions in sensors and wireless communication technologies. For WBAN technology improvisation, researchers are mainly concentrating on technical parameters of health monitoring to make it interactive and real time based. A WBAN is an integration of Wireless Sensor Networks (WSNs) to connect various Biomedical Wireless Sensors (BWSs) located inside and outside of the human body to collect and transmit vital signals. The collected biomedical data is send to the hospitals and medical centres for therapeutic, diagnostic analysis and treatment. An electrocardiogram (ECG), a non-invasive mechanism, is widely used to establish medical diagnosis of heart diseases in health care systems. This paper presents a microcontroller ARM7 based health monitoring system intended to monitor and to early detect situations when heart rate and blood oxygen level are out of their safe ranges. The main objective of this proposal is to prevent emergency situations by informing the patient to take actions before patient's health condition get worse leading to emergency medical care. This system employs a programmable ARM7 for confab the bio-signal to determine the condition of heart. If any abnormalities are discovered from patient's heart parameters, the system sends alarm to the doctor. The system ensures wireless transmission of ECG signal to the Medical Server (doctor's PC) through Bluetooth and Android platform. This endows doctor to have visual description of patient's ECG on Medical Server and if critical condition exists, system will send alert messages to the doctor on his mobile phone even if doctor is away from Medical server. The experimental result shows that the device is compact, cheap, user friendly and useful.
由于传感器和无线通信技术的巨大发展,无线体域网络(WBAN)正在跨越式发展。对于无线宽带网络技术的改进,研究人员主要关注健康监测的技术参数,使其具有互动性和实时性。无线宽带网络(WBAN)是无线传感器网络(wsn)的集成,用于连接人体内外的各种生物医学无线传感器(BWSs),以收集和传输生命信号。收集到的生物医学数据被送到医院和医疗中心进行治疗、诊断分析和治疗。心电图(electrocardiogram, ECG)作为一种无创机制,在医疗保健系统中被广泛应用于心脏病的医学诊断。本文提出了一种基于ARM7单片机的健康监测系统,旨在监测和早期检测心率和血氧水平超出安全范围的情况。该提案的主要目的是在患者的健康状况恶化导致紧急医疗护理之前,通过告知患者采取行动来预防紧急情况。该系统采用可编程ARM7对生物信号进行配置,以确定心脏状况。如果发现病人的心脏参数有任何异常,系统就会向医生发出警报。该系统通过蓝牙和Android平台将心电信号无线传输到医疗服务器(医生的PC)。这使得医生可以在医疗服务器上对患者的心电图进行直观的描述,如果存在危重情况,即使医生不在医疗服务器上,系统也会向医生的手机发送警报信息。实验结果表明,该装置结构紧凑,价格低廉,操作方便,实用性强。
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引用次数: 12
Smart brace for monitoring patients with scoliosis using a multimodal sensor board solution 使用多模态传感器板解决方案监测脊柱侧凸患者的智能支架
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797698
O. Dehzangi, M. Mohammadi, Y. Li
The aim of this study is to develop a platform to monitor compliance with brace treatment in patients with scoliosis. Scoliosis is a curvature of the spine that frequently occurs in adolescents. Nonoperative treatment with a thoracolumbosacral orthosis (TLSO) is widely used. However, a brace that is not worn correctly is not effective at controlling scoliosis, regardless of the duration of brace wear. As a solution for monitoring these patients, we developed a low power multi-modal sensor board capable of: 1) logging pressure distribution inside the brace using analog pressure sensors and 2) detecting different activities that the patient is involved in using accelerometer sensor. We employ the two modalities of signals recorded from the brace to achieve high precision compliance monitoring system. Our data processing algorithm suite includes a two-stage data classification design. In the first stage, we detect six predefined activities including: standing, sitting, walking, running, lying down, and climbing the stairs using an embedded motion sensor. In the second stage, we detect four levels of brace tightness based on features extracted from internal force sensors and activity specific models. Our results demonstrated high levels of accuracy for activity and tightness level classification.
本研究的目的是开发一个监测脊柱侧凸患者支架治疗依从性的平台。脊柱侧弯是一种脊柱弯曲,常见于青少年。非手术治疗胸腰骶矫形器(TLSO)被广泛使用。然而,不正确佩戴的支具不能有效控制脊柱侧凸,无论支具佩戴的时间长短。作为监测这些患者的解决方案,我们开发了一种低功耗多模态传感器板,能够:1)使用模拟压力传感器记录支架内的压力分布;2)使用加速度传感器检测患者参与的不同活动。我们采用两种模式的信号从支架记录,以实现高精度的依从性监测系统。我们的数据处理算法套件包括一个两阶段的数据分类设计。在第一阶段,我们使用嵌入式运动传感器检测六种预定义的活动,包括:站、坐、走、跑、躺和爬楼梯。在第二阶段,我们根据从内力传感器和活动特定模型中提取的特征检测出四个级别的支撑紧度。我们的结果证明了活动和紧密程度分类的高水平准确性。
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引用次数: 4
Computer aided detection of cavernous malformation in T2-weighted brain MR images 脑t2加权MR图像海绵样畸形的计算机辅助检测
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797707
Huiquan Wang, Hongming Xu, S. N. Ahmed, M. Mandai
Cavernous malformation or cavernomas is abnormal development of brain blood vessels and affect an estimated 0.5% of the world population. These could cause seizures, intracerebral hemorrhage and various neurological deficits based on the location of the lesion. Radiologists usually analysis brain magnetic resonance (MR) images to detect cavernomas. However, automatic detection of cavernomas by computer has not been investigated enough. This paper proposes a computer aided cavernomas detection method based on MR images analysis. The proposed method includes three steps: brain extraction based on deformable contour (to remove the non-brain tissues from image), template matching (to find suspected cavernomas regions) and post-processing (to get rid of false positives based on size, shape and brightness information). The performance of the proposed technique is evaluated and a sensitivity of 0.92 is obtained after testing.
海绵体畸形或海绵体瘤是脑血管的异常发育,估计影响世界人口的0.5%。这些可能会引起癫痫发作、脑出血和基于病变位置的各种神经功能障碍。放射科医生通常分析脑磁共振(MR)图像来检测海绵状瘤。然而,计算机对海绵状瘤的自动检测还没有足够的研究。本文提出了一种基于MR图像分析的计算机辅助海绵瘤检测方法。该方法包括三个步骤:基于可变形轮廓的脑提取(从图像中去除非脑组织)、模板匹配(寻找疑似海绵瘤区域)和后处理(基于大小、形状和亮度信息去除误报)。对该技术的性能进行了评价,测试后的灵敏度为0.92。
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引用次数: 2
Characterization and application of a discrete quartz extended-gate ISFET for the assessment of tumor cell viability 用于评估肿瘤细胞活力的离散石英扩展栅极ISFET的特性和应用
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797697
Hany M Arafa, U. Obahiagbon, D. Kullman, Fatima-Joyce Dominguez, Abigail Magee, J. Christen
In this work we present a system designed for continuous assessment of tumor cell extracellular pH using a fabricated quartz extended-gate ion-sensitive field effect transistor (EGFET). The extended gate structure was fabricated by patterning gold on a quartz substrate creating a pseudo-reference electrode and sensor below a Si3N4 sensing membrane. Various electrode geometries and configurations were created and each pattern was characterized. A readout/data acquisition system was designed to convert the current output of the EGFET to a voltage that was recorded using a low-power single board computer, which performed a hard "reset" before every data acquisition interval. This setup was able to monitor the viability of SKBR3 mammary gland tumor cells treated with staurosporine. Over a span of 8 hours, the autonomous data acquisition system recorded a steady decrease in cell viability. Results were verified with periodic cell culture images. Future applications include design of an extended gate EGFET array, which allows for accurate monitoring of individual cell cultures.
在这项工作中,我们提出了一种设计用于连续评估肿瘤细胞细胞外pH值的系统,该系统使用了一种制造的石英扩展栅离子敏感场效应晶体管(EGFET)。扩展栅极结构是通过在石英衬底上图案化金来制造的,在Si3N4传感膜下创建了伪参考电极和传感器。创建了各种电极几何形状和配置,并对每种模式进行了表征。设计了一个读出/数据采集系统,将EGFET的电流输出转换为电压,使用低功耗单板计算机记录电压,在每个数据采集间隔之前执行硬“复位”。该装置能够监测经staurosporine处理的SKBR3乳腺肿瘤细胞的生存能力。在8小时的时间内,自主数据采集系统记录到细胞活力稳步下降。用周期性细胞培养图像验证结果。未来的应用包括扩展栅极EGFET阵列的设计,它可以精确地监测单个细胞培养。
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引用次数: 4
CryoPen®, A gasless cryotherapy system adapted for low-resource settings CryoPen®,一种适用于低资源环境的无气体冷冻治疗系统
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797714
M. Cremer, Jillian Garai, L. Taxa, M. Salinas, J. Felix, K. Alfaro, Michael Haas, Albert Zevallos
The development of human papillomavirus screening tests is outpacing the introduction of new treatment technologies. In low-resource settings, there is an urgent need for treatment methods that are accessible, affordable, and sustainable in areas with limited medical infrastructure. The gasless CryoPen® Cryosurgical System overcomes the limitations of traditional gas-based cryotherapy and is being adapted specifically for use in low-resource areas. The innovative device demonstrates exceptional portability, durability, and efficiency. The adapted CryoPen® is a simple, safe, and practical option for treatment of cervical precancer in settings that cannot support gas-based cryotherapy.
人乳头瘤病毒筛查试验的发展速度超过了新治疗技术的引进速度。在资源匮乏的环境中,医疗基础设施有限的地区迫切需要可获得、负担得起和可持续的治疗方法。无气体CryoPen®冷冻手术系统克服了传统气体冷冻疗法的局限性,特别适用于资源匮乏地区。这一创新设备展示了卓越的便携性、耐用性和效率。改良后的CryoPen®是一种简单、安全、实用的宫颈癌前病变治疗方案,适用于不能支持气体冷冻疗法的环境。
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引用次数: 1
Towards the evaluation of force-sensing resistors for in situ measurement of interface pressure during leg compression therapy 腿受压治疗中原位测量界面压力的力感电阻评估
Pub Date : 2016-11-01 DOI: 10.1109/HIC.2016.7797688
Mahan Rahimi, A. Blaber, C. Menon
While compression therapy is the cornerstone in managing leg venous disorders, the applied pressure has to be in specific ranges in order to have an effective treatment. Medical bandages and compression stockings lack an embedded pressure measurement system. The listed class of compression for medical stockings is not utterly reliable, and achieving desired pressure profiles in medical bandages is dependent solely on the bandaging skills of clinicians. Moreover, after the recipients of compression products leave medical centers, there exists no way to continuously assess the changes in sub-bandage pressure that might occur due to movements and physiological changes of the lower extremities. Thus there is a need for a valid and reliable measurement system that can be integrated into compression products for continuous monitoring of the interface pressure. In the current study, force-sensing resistors (FSRs®), which are portable, thin, flexible, low-cost, and easy-to-use sensors, were investigated. FSRs, like many other flexible resistive sensors, are known for their qualitative rather than quantitative measurements. Therefore, they should be validated for clinical use. In this study, the FSRs were first calibrated on different surfaces, including human leg, and then evaluated in measuring interface pressures in situ. The preliminary investigations showed promising results.
虽然压迫疗法是管理腿部静脉疾病的基石,但施加的压力必须在特定范围内,以便有效治疗。医用绷带和压缩袜缺乏嵌入式压力测量系统。列出的医用丝袜的压缩等级并不完全可靠,在医用绷带中实现所需的压力概况完全取决于临床医生的包扎技能。此外,在接受压缩产品的患者离开医疗中心后,没有办法持续评估由于下肢运动和生理变化而可能发生的绷带下压力变化。因此,需要一种有效可靠的测量系统,可以集成到压缩产品中,以连续监测界面压力。在目前的研究中,力感电阻(FSRs®)是一种便携式,薄,灵活,低成本和易于使用的传感器。fsr,像许多其他柔性电阻传感器一样,以定性而非定量测量而闻名。因此,它们应该经过临床应用验证。在这项研究中,fsr首先在不同的表面(包括人腿)上进行校准,然后在原位测量界面压力进行评估。初步调查显示出可喜的结果。
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引用次数: 7
期刊
2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)
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