Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797696
D. Blanco, J. Annen, A. Piarulli, A. Díaz-Méndez, Steven Laureys
In this paper is presented an analysis of the phase lag index (PLI) in healthy controls and patients with disorders of consciousness aimed to find differences in connectivity of brain sources between these two states in different frequency bands. It was analyzed a total of 50 EEGs, 28 from healthy patients and 22 from patients with disorders of consciousness with two kind of montages, bipolar and mastoid referenced. The patients show a higher PLI in lower frequency bands with significative differences for interhemispheric distances between electrodes using a mastoid reference.
本文通过对健康对照者和意识障碍患者的相位滞后指数(phase lag index, PLI)进行分析，旨在发现两种状态下不同频带的脑源连通性的差异。对50例脑电图进行分析，其中健康患者28例，意识障碍患者22例，采用双相和乳突两种蒙太奇对照。患者在较低频段显示更高的PLI，使用乳突参考电极之间的半球间距离有显著差异。
{"title":"A phased lag index study in patients with disorders of consciousness","authors":"D. Blanco, J. Annen, A. Piarulli, A. Díaz-Méndez, Steven Laureys","doi":"10.1109/HIC.2016.7797696","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797696","url":null,"abstract":"In this paper is presented an analysis of the phase lag index (PLI) in healthy controls and patients with disorders of consciousness aimed to find differences in connectivity of brain sources between these two states in different frequency bands. It was analyzed a total of 50 EEGs, 28 from healthy patients and 22 from patients with disorders of consciousness with two kind of montages, bipolar and mastoid referenced. The patients show a higher PLI in lower frequency bands with significative differences for interhemispheric distances between electrodes using a mastoid reference.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"28 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116594329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797711
U. Obahiagbon, D. Kullman, Joseph T. Smith, B. Katchman, Hany M Arafa, K. Anderson, J. Christen
This work details the design and characterization of a low-cost, portable and highly sensitive fluorescence detection system intended for use in a compact and disposable point-of-care (POC) device. The detection device leverages time integration to improve the signal to noise ratio (SNR) compared to instantaneous measurements. It also eliminates complicated focusing optics and electronics typically found in bulky and expensive laboratory-scale devices. Characterization was performed by measuring a series of logarithmically scaled dilutions of 1 μm Nile Red fluorescent microspheres immobilized on microscope slides. This approach eliminates assay dependencies and elucidates the actual system performance. A theoretical model that predicts the time-integrated output voltage profile of the sensor was developed; this prediction is useful for evaluating any lens-free fluorescent system based on a set of filters and choice of fluorophore. By relating the fluorophore concentration, system design parameters, and the output voltage, the model matches well with the empirical data and the limit of determination (LOD) for Nile Red is 20 particles. This system provides a sensitive and potentially low-cost device for fluorescent diagnosis in an integrated and compact/miniaturized POC device, lab-on-chip or a table-top reader.
{"title":"Characterization of a compact and highly sensitive fluorescence-based detection system for point-of-care applications","authors":"U. Obahiagbon, D. Kullman, Joseph T. Smith, B. Katchman, Hany M Arafa, K. Anderson, J. Christen","doi":"10.1109/HIC.2016.7797711","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797711","url":null,"abstract":"This work details the design and characterization of a low-cost, portable and highly sensitive fluorescence detection system intended for use in a compact and disposable point-of-care (POC) device. The detection device leverages time integration to improve the signal to noise ratio (SNR) compared to instantaneous measurements. It also eliminates complicated focusing optics and electronics typically found in bulky and expensive laboratory-scale devices. Characterization was performed by measuring a series of logarithmically scaled dilutions of 1 μm Nile Red fluorescent microspheres immobilized on microscope slides. This approach eliminates assay dependencies and elucidates the actual system performance. A theoretical model that predicts the time-integrated output voltage profile of the sensor was developed; this prediction is useful for evaluating any lens-free fluorescent system based on a set of filters and choice of fluorophore. By relating the fluorophore concentration, system design parameters, and the output voltage, the model matches well with the empirical data and the limit of determination (LOD) for Nile Red is 20 particles. This system provides a sensitive and potentially low-cost device for fluorescent diagnosis in an integrated and compact/miniaturized POC device, lab-on-chip or a table-top reader.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131093665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797721
Katerina Hadjigeorgiou, E. Kastanos, C. Pitris
Urinary Tract Infections (UTIs) are some of the most common bacterial diseases, especially in women, resulting in millions of hospital visits and a cost of 1.6 billion dollars every year in the US alone. Currently, diagnosis is performed with two sequential urine cultures, for species identification and antibiotic susceptibility testing, which require a total of 48 hrs. The limitations of the current scheme can be overcome by the development of a Surface Enhanced Raman Spectroscopy (SERS) based diagnostic. The proposed technology can: (i) identify the presence of bacteria (correctly quantifies the concentration and specifies the bacteurimic samples), (ii) classify the causative bacteria (~94% correct classification), and (iii) determine the sensitivity of the bacteria to various antibiotics (81-100% correct classification depending on the antibiotic). These results demonstrate that SERS can be used for complete, fast, accurate, and inexpensive POCT for urinary tract and other bacterial infections.
{"title":"Surface enhanced Raman spectroscopy as a tool for rapid and inexpensive diagnosis and antibiotic susceptibility testing for urinary tract infections","authors":"Katerina Hadjigeorgiou, E. Kastanos, C. Pitris","doi":"10.1109/HIC.2016.7797721","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797721","url":null,"abstract":"Urinary Tract Infections (UTIs) are some of the most common bacterial diseases, especially in women, resulting in millions of hospital visits and a cost of 1.6 billion dollars every year in the US alone. Currently, diagnosis is performed with two sequential urine cultures, for species identification and antibiotic susceptibility testing, which require a total of 48 hrs. The limitations of the current scheme can be overcome by the development of a Surface Enhanced Raman Spectroscopy (SERS) based diagnostic. The proposed technology can: (i) identify the presence of bacteria (correctly quantifies the concentration and specifies the bacteurimic samples), (ii) classify the causative bacteria (~94% correct classification), and (iii) determine the sensitivity of the bacteria to various antibiotics (81-100% correct classification depending on the antibiotic). These results demonstrate that SERS can be used for complete, fast, accurate, and inexpensive POCT for urinary tract and other bacterial infections.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134277443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797695
Qian He, E. Agu
Sedentary behaviors such as prolonged occupational and leisure-time sitting are now ubiquitous in modern societies. Sedentary time is positively associated with increased risk of obesity, diabetes, cardiovascular disease, and all-cause mortality. Smartphones can sense the sedentary behaviors performed by their users, as well as the contexts (situations) in which sedentary behaviors occur. In this paper, we explore whether the contexts that can be sensed by users' smartphones can be used to predict their future sedentary behaviors reliably. We analyze data gathered in a term-long study of 49 college students in order to discover their sedentary behavior patterns and contexts strongly correlated with sedentary states. The ability to predict sedentary behaviors will facilitate more effective computer-driven interventions based on the theory of planned behavior. Using logistic regression, we are able to classify user context variables such as location, time, and app usage to predict if the user will be "very sedentary" in the next hour with a precision of 73.1% (recall of 87.7%).
{"title":"Smartphone usage contexts and sensable patterns as predictors of future sedentary behaviors","authors":"Qian He, E. Agu","doi":"10.1109/HIC.2016.7797695","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797695","url":null,"abstract":"Sedentary behaviors such as prolonged occupational and leisure-time sitting are now ubiquitous in modern societies. Sedentary time is positively associated with increased risk of obesity, diabetes, cardiovascular disease, and all-cause mortality. Smartphones can sense the sedentary behaviors performed by their users, as well as the contexts (situations) in which sedentary behaviors occur. In this paper, we explore whether the contexts that can be sensed by users' smartphones can be used to predict their future sedentary behaviors reliably. We analyze data gathered in a term-long study of 49 college students in order to discover their sedentary behavior patterns and contexts strongly correlated with sedentary states. The ability to predict sedentary behaviors will facilitate more effective computer-driven interventions based on the theory of planned behavior. Using logistic regression, we are able to classify user context variables such as location, time, and app usage to predict if the user will be \"very sedentary\" in the next hour with a precision of 73.1% (recall of 87.7%).","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124885598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797719
R. Macko, T. Forrester, Patrice A. Francis, G. Nelson, C. Hafer-Macko, A. Roy
Stroke is a growing global public health issue in low and middle income countries, where prevalence rates for cerebrovascular events now exceed those in industrialized nations. Limited access to stroke rehabilitation, which includes prevention of physical inactivity and deconditioning to better manage risk factors for recurrent vascular events, remains a major barrier to care. In the Caribbean Community, this is compounded by population trends in aging and obesity that also require an integrative health education and nutrition program to manage the myriad metabolic risk factors that drive pan-vascular disease. To begin to address this gap, we developed Interactive Video Exercise Tele-rehabilitation (IVET) as a web-based and smart device linked technology to deliver personalized exercise rehabilitation, coupled as needed with nutrition and health education. The exercise program uses a pull down menu Avatar remotely manageable by a coach to personalize visual-motor reinforced mobility focused training, according to each individual's observed neurological and cardiopulmonary capacities. Rate and duration of exercise are adjusted to produce a measured aerobic intensity known to improve cardiovascular health. This initial report describes the IVET technology as a wireless tool for low and middle income countries, and demonstrates the exercise rehabilitation safety and performance profiles, and ratings for acceptance of the technology for 27 Jamaican adults with hemiparetic stroke.
{"title":"Interactive video exercise tele-rehabilitation (IVET) for stroke care in Jamaica","authors":"R. Macko, T. Forrester, Patrice A. Francis, G. Nelson, C. Hafer-Macko, A. Roy","doi":"10.1109/HIC.2016.7797719","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797719","url":null,"abstract":"Stroke is a growing global public health issue in low and middle income countries, where prevalence rates for cerebrovascular events now exceed those in industrialized nations. Limited access to stroke rehabilitation, which includes prevention of physical inactivity and deconditioning to better manage risk factors for recurrent vascular events, remains a major barrier to care. In the Caribbean Community, this is compounded by population trends in aging and obesity that also require an integrative health education and nutrition program to manage the myriad metabolic risk factors that drive pan-vascular disease. To begin to address this gap, we developed Interactive Video Exercise Tele-rehabilitation (IVET) as a web-based and smart device linked technology to deliver personalized exercise rehabilitation, coupled as needed with nutrition and health education. The exercise program uses a pull down menu Avatar remotely manageable by a coach to personalize visual-motor reinforced mobility focused training, according to each individual's observed neurological and cardiopulmonary capacities. Rate and duration of exercise are adjusted to produce a measured aerobic intensity known to improve cardiovascular health. This initial report describes the IVET technology as a wireless tool for low and middle income countries, and demonstrates the exercise rehabilitation safety and performance profiles, and ratings for acceptance of the technology for 27 Jamaican adults with hemiparetic stroke.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130162342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797733
M. Slayton, Richard C. Amodei, Keegan B. Compton, D. Latt, J. Kearney
Background/Objective: Intense Therapy Ultrasound (ITU) effectively creates thermal injury zones inside soft tissue, initiating a tissue repair cascade in the skin, promoting collagen generation. It may be feasible to promote a robust healing response in musculoskeletal tissue accelerating healing from injury [1]. The objectives of the studies were to establish the feasibility of treatment by High Frequency ITU for Plantar Fasciitis and Lateral Epicondylitis. Protocols/Methods: Chronic Plantar Fasciitis: Two treatments, 2 weeks apart, 38 patients, (27-treated, 11-sham group) consisted of 250-320 80 msec pulses creating matrices of small ablative thermal lesions of 4-5 joules at a pre-programmed pitch of 1.6 mm. Each treatment did not exceed 12 minutes. Treatment effects were assessed with diagnostic ultrasound imaging at 12 MHz. Ultrasound images were analyzed to determine changes in peri-fascial lesion size. Patients reported outcomes at 2, 4 6 and 12 weeks after initiating treatment [2]. Chronic Lateral Epicondylitis: Two treatments, 4 weeks apart, 24 patients, consisting of 80 14 msec pulses creating matrices of small ablative thermal lesions of 1 joule. Manually targeted area mapped by diagnostic ultrasound imaging. Each treatment was less than 10 minutes. Treatment effects were assessed with diagnostic ultrasound at 17MHz. Patient reported outcomes at 2, 4, 8 and 12 weeks after initial treatment. For both studies patients randomized, the principal investigator, sonographer and study coordinator administering the study were blinded to clinical assessments and diagnostic ultrasound results. Results/Conclusions: Plantar Fasciitis: Results of the double blinded, randomized, sham controlled study for the treatment of Plantar Fasciitis with ITU appeared to have significant positive results within 12 weeks' post-treatment in 81% of patients treated. Both quantitative measurements from diagnostic ultrasound imaging and applied standardized assessment protocols showed statistically significant coincidental improvements in treated patients vs. control group. Chronic Lateral Epicondylitis: Statistically significant improvements were seen in 75% of patients and diagnostic ultrasound images show significant reduction in free fluid at 8 weeks compared to baseline images in patients with no to mild peri-tendon calcifications. These patients correlated well with significantly improved PRTEE survey scores. Few patients with little or no improvement in PRTEE scores consistently presented with moderate to severe peri-tendon calcifications.
{"title":"Musculoskeletal treatments using intense therapy ultrasound: Clinical studies for chronic plantar fasciitis and lateral epicondylitis","authors":"M. Slayton, Richard C. Amodei, Keegan B. Compton, D. Latt, J. Kearney","doi":"10.1109/HIC.2016.7797733","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797733","url":null,"abstract":"Background/Objective: Intense Therapy Ultrasound (ITU) effectively creates thermal injury zones inside soft tissue, initiating a tissue repair cascade in the skin, promoting collagen generation. It may be feasible to promote a robust healing response in musculoskeletal tissue accelerating healing from injury [1]. The objectives of the studies were to establish the feasibility of treatment by High Frequency ITU for Plantar Fasciitis and Lateral Epicondylitis. Protocols/Methods: Chronic Plantar Fasciitis: Two treatments, 2 weeks apart, 38 patients, (27-treated, 11-sham group) consisted of 250-320 80 msec pulses creating matrices of small ablative thermal lesions of 4-5 joules at a pre-programmed pitch of 1.6 mm. Each treatment did not exceed 12 minutes. Treatment effects were assessed with diagnostic ultrasound imaging at 12 MHz. Ultrasound images were analyzed to determine changes in peri-fascial lesion size. Patients reported outcomes at 2, 4 6 and 12 weeks after initiating treatment [2]. Chronic Lateral Epicondylitis: Two treatments, 4 weeks apart, 24 patients, consisting of 80 14 msec pulses creating matrices of small ablative thermal lesions of 1 joule. Manually targeted area mapped by diagnostic ultrasound imaging. Each treatment was less than 10 minutes. Treatment effects were assessed with diagnostic ultrasound at 17MHz. Patient reported outcomes at 2, 4, 8 and 12 weeks after initial treatment. For both studies patients randomized, the principal investigator, sonographer and study coordinator administering the study were blinded to clinical assessments and diagnostic ultrasound results. Results/Conclusions: Plantar Fasciitis: Results of the double blinded, randomized, sham controlled study for the treatment of Plantar Fasciitis with ITU appeared to have significant positive results within 12 weeks' post-treatment in 81% of patients treated. Both quantitative measurements from diagnostic ultrasound imaging and applied standardized assessment protocols showed statistically significant coincidental improvements in treated patients vs. control group. Chronic Lateral Epicondylitis: Statistically significant improvements were seen in 75% of patients and diagnostic ultrasound images show significant reduction in free fluid at 8 weeks compared to baseline images in patients with no to mild peri-tendon calcifications. These patients correlated well with significantly improved PRTEE survey scores. Few patients with little or no improvement in PRTEE scores consistently presented with moderate to severe peri-tendon calcifications.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122898942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797716
Andrea García, F. Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Olivia Sanchez, M. Ramirez, M. Godinez, M. L. Coco, J. Azpiroz, M. Borsody, E. Sacristán
Stroke affects more than 16 M people worldwide and emergency treatments are available for less than 5% of the patients. Magnetic stimulation of the facial nerve has been tested in pre-clinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of this study in healthy human subjects is to help understand the safety, tolerability, and effectiveness of a clinical prototype facial nerve stimulator as a first step toward clinical studies in ischemic stroke patients. The geniculate ganglion region of the facial nerve was located bilaterally with neuronavigation and then stimulated in 35 healthy subjects. Safety was assessed with adverse event reports and by medical examination in all 35 subjects. Tolerability was defined as each subjects' self-determined ability to withstand at least 2 minutes of stimulation at escalating power levels. MRI perfusion cerebral blood flow (CBF) measurements were available in 31 of the subjects. Stimulation produced a clear (> 25%) increase in CBF in 10 of 31 subjects, and smaller increases in most of the remaining subjects. These results support the development of our device as an emergency ischemic stroke treatment.
{"title":"Facial nerve stimulation in healthy human subjects","authors":"Andrea García, F. Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Olivia Sanchez, M. Ramirez, M. Godinez, M. L. Coco, J. Azpiroz, M. Borsody, E. Sacristán","doi":"10.1109/HIC.2016.7797716","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797716","url":null,"abstract":"Stroke affects more than 16 M people worldwide and emergency treatments are available for less than 5% of the patients. Magnetic stimulation of the facial nerve has been tested in pre-clinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of this study in healthy human subjects is to help understand the safety, tolerability, and effectiveness of a clinical prototype facial nerve stimulator as a first step toward clinical studies in ischemic stroke patients. The geniculate ganglion region of the facial nerve was located bilaterally with neuronavigation and then stimulated in 35 healthy subjects. Safety was assessed with adverse event reports and by medical examination in all 35 subjects. Tolerability was defined as each subjects' self-determined ability to withstand at least 2 minutes of stimulation at escalating power levels. MRI perfusion cerebral blood flow (CBF) measurements were available in 31 of the subjects. Stimulation produced a clear (> 25%) increase in CBF in 10 of 31 subjects, and smaller increases in most of the remaining subjects. These results support the development of our device as an emergency ischemic stroke treatment.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122799124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797731
N. Selvaraj
Development of wearable medical devices to measure noninvasive blood pressure (NIBP) has recently been evolving at finger/wrist and earlobe locations. The study investigates the predictive power of pulse transit time (PTT) and pulse arrival time (PAT) measured at finger and earlobe sites for BP measurement during two unique physiological interventions: handgrip test (HGT) and modified Valsalva test (mVT). Single-lead electrocardiogram, impedance cardiogram, infrared photoplethysmogram (PPG) from finger and earlobe, and CNAP® NIBP were simultaneously acquired in 14 heathy subjects (39±11 years); beat-to-beat BP, PAT and PTT were extracted; linear regression, correlation and statistical analyses were carried out. The results show that both the BP interventions caused significant increase (P<;0.05) in diastolic blood pressure (DBP), but concurrent significant decrease (P<;0.01) in PTT was observed only during mVT in both finger and earlobe sites. On the other hand, PAT did not change significantly during both the BP interventions. PTT showed highest correlation (R2) of 0.47±0.26 and negative regression slope of - 0.39±0.31 with DBP in finger during mVT compared to earlobe. Thus, the predictive power of PTT for NIBP monitoring vary broadly in distinct BP regulation mechanisms, and found to be moderate in finger site and relatively weak in earlobe site.
{"title":"Assessment of pulse transit/arrival time as noninvasive blood pressure predictors in finger and earlobe sites","authors":"N. Selvaraj","doi":"10.1109/HIC.2016.7797731","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797731","url":null,"abstract":"Development of wearable medical devices to measure noninvasive blood pressure (NIBP) has recently been evolving at finger/wrist and earlobe locations. The study investigates the predictive power of pulse transit time (PTT) and pulse arrival time (PAT) measured at finger and earlobe sites for BP measurement during two unique physiological interventions: handgrip test (HGT) and modified Valsalva test (mVT). Single-lead electrocardiogram, impedance cardiogram, infrared photoplethysmogram (PPG) from finger and earlobe, and CNAP® NIBP were simultaneously acquired in 14 heathy subjects (39±11 years); beat-to-beat BP, PAT and PTT were extracted; linear regression, correlation and statistical analyses were carried out. The results show that both the BP interventions caused significant increase (P<;0.05) in diastolic blood pressure (DBP), but concurrent significant decrease (P<;0.01) in PTT was observed only during mVT in both finger and earlobe sites. On the other hand, PAT did not change significantly during both the BP interventions. PTT showed highest correlation (R2) of 0.47±0.26 and negative regression slope of - 0.39±0.31 with DBP in finger during mVT compared to earlobe. Thus, the predictive power of PTT for NIBP monitoring vary broadly in distinct BP regulation mechanisms, and found to be moderate in finger site and relatively weak in earlobe site.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129067814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797729
Ahmad Hassan Mirza, Nuno Miguel Matos Pires, T. Dong
Organic Photo Detectors (OPD) present an attractive detection system to be incorporated in Point of Care (POC) disposable diagnostic devices due to their low cost fabrication and flexible device structure. Indium Tin Oxide (ITO) is the most commonly used material for the fabrication of transparent anode for these devices. The fabrication of ITO is an expensive process and the rarity of the materials required itself makes this the cost driving factor in realizing cheap and hence disposable detection system for the POC devices. Furthermore ITO has a spiked morphology that results in a shorter device lifetime. All these disadvantages associated with ITO have made the search for an alternative material for ITO which has comparable characteristics an important research field. In this study we explore the possibility of utilizing a commercially available high conductivity grade solution of PEDOT:PSS and further enhance its characteristics by addition of gold nano particles and a MEMS structure to enhance the photo absorption of the OPD by increased surface area. The reported results show comparable sheet resistance values (18.2 Ω/sq for the fabricated electrode) and optical characteristics to the ITO electrode and a much better surface morphology characteristics for the new fabricated electrode.
{"title":"ITO-free 3D MEMS photodetector for point-of-care biosensing devices","authors":"Ahmad Hassan Mirza, Nuno Miguel Matos Pires, T. Dong","doi":"10.1109/HIC.2016.7797729","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797729","url":null,"abstract":"Organic Photo Detectors (OPD) present an attractive detection system to be incorporated in Point of Care (POC) disposable diagnostic devices due to their low cost fabrication and flexible device structure. Indium Tin Oxide (ITO) is the most commonly used material for the fabrication of transparent anode for these devices. The fabrication of ITO is an expensive process and the rarity of the materials required itself makes this the cost driving factor in realizing cheap and hence disposable detection system for the POC devices. Furthermore ITO has a spiked morphology that results in a shorter device lifetime. All these disadvantages associated with ITO have made the search for an alternative material for ITO which has comparable characteristics an important research field. In this study we explore the possibility of utilizing a commercially available high conductivity grade solution of PEDOT:PSS and further enhance its characteristics by addition of gold nano particles and a MEMS structure to enhance the photo absorption of the OPD by increased surface area. The reported results show comparable sheet resistance values (18.2 Ω/sq for the fabricated electrode) and optical characteristics to the ITO electrode and a much better surface morphology characteristics for the new fabricated electrode.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114205928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.1109/HIC.2016.7797704
C. Phaneuf, V. Vandernoot, Chung-Yan Koh
The threats of disease outbreaks and exposure to biothreat agents, both accidental and intentional, demand field-deployable technology capable of rapid, sensitive, and accurate diagnosis. In order to address these public health concerns, we present a portable centrifugal microfluidic platform and demonstrate sensitive detection protein antigens, host response antibodies, and nucleic acids down to single digit starting copies. The nucleic acid detection utilizes an isothermal amplification via loop-mediated isothermal amplification (LAMP). The platform, which is composed of a compact optical system for laser induced fluorescence (LIF) detection, a quiet brushless motor, and an efficient non-contact heater, offers an easy-to-use system capable of performing sensitive biodetection in a constrained-resource environment.
{"title":"Portable centrifugal microfluidic system for diagnostics in resource-limited settings","authors":"C. Phaneuf, V. Vandernoot, Chung-Yan Koh","doi":"10.1109/HIC.2016.7797704","DOIUrl":"https://doi.org/10.1109/HIC.2016.7797704","url":null,"abstract":"The threats of disease outbreaks and exposure to biothreat agents, both accidental and intentional, demand field-deployable technology capable of rapid, sensitive, and accurate diagnosis. In order to address these public health concerns, we present a portable centrifugal microfluidic platform and demonstrate sensitive detection protein antigens, host response antibodies, and nucleic acids down to single digit starting copies. The nucleic acid detection utilizes an isothermal amplification via loop-mediated isothermal amplification (LAMP). The platform, which is composed of a compact optical system for laser induced fluorescence (LIF) detection, a quiet brushless motor, and an efficient non-contact heater, offers an easy-to-use system capable of performing sensitive biodetection in a constrained-resource environment.","PeriodicalId":333642,"journal":{"name":"2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference (HI-POCT)","volume":"221 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116375846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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