Pub Date : 2021-12-06DOI: 10.25207/1608-6228-2021-28-6-117-132
V. V. Fedyushkin, A. G. Barishev
{"title":"Vacuum-assisted healing of various-aetiology wounds: A systematic review","authors":"V. V. Fedyushkin, A. G. Barishev","doi":"10.25207/1608-6228-2021-28-6-117-132","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-6-117-132","url":null,"abstract":"","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49663148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-06DOI: 10.25207/1608-6228-2021-28-6-90-116
S. Kanorskii
{"title":"Post-COVID syndrome: prevalence, organ pathogenesis and routes of correction. A systematic review","authors":"S. Kanorskii","doi":"10.25207/1608-6228-2021-28-6-90-116","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-6-90-116","url":null,"abstract":"","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42701673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-06DOI: 10.25207/1608-6228-2021-28-6-59-72
A. A. Kurmangulov, Y. Reshetnikova
{"title":"Public intent profile towards medical facility visualisation systems in russian federation: a one-stage sociological survey","authors":"A. A. Kurmangulov, Y. Reshetnikova","doi":"10.25207/1608-6228-2021-28-6-59-72","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-6-59-72","url":null,"abstract":"","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48645333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-117-130
S. Chepurnenko, G. Shavkuta, A. V. Safonova
Background. The prevalence of heterozygous familial hypercholesterolaemia (HeFH) comprises 1 per 250 people. The risk of premature cardiovascular disease (CVD) is 20 times higher in HeFH patients among the general population. CVD develops in HeFH patients under 20 years of age, and they usually do not survive to 30 years. Therefore, the primary treatment track here is correction of dyslipidaemia to prevent atherosclerosis progression and CVD. Clinical Case Descriptions. The article describes the clinical cases of familial dyslipidaemia in 47-yo patient M. and his 75-yo mother P. The patient had a visit related to blood pressure (BP) surges up to 140/90 mm Hg. In history: acute myocardial infarction (AMI) in maternal grandfather at 50 years and own uncle at 32 years. The patient’s cardiovascular risk factors: male gender, dyslipidaemia (total cholesterol (TC) 15.8 mmol/L), overweight (body mass index 29.9 kg/m2), familial history of young CVD, sedentary lifestyle (employed as manager), psychological and socioeconomic factors (work-related stress pressure), resting heart rate 88 beats/min. The patient was immediately ordered a combined hypolipidaemic therapy including rosuvastatin 20 mg, ezetimibe 10 mg, telmisartan 40 mg once daily for blood pressure correction. In 1-month therapy, cholesterol dropped to 4.4 mmol/L, low-density lipoprotein (LDL) cholesterol – to 2.2, but triglycerides remained high at 3.9 mmol/L. Fenofi brate added to therapy at 145 mg 1 time. Another 1-month therapy allowed the overall reduction of TC to 3.7, LDL cholesterol to 1.9, triglycerides to 2.17 and high-density lipoproteins to 1.19 mmol/L. Past 3 months, a further drop was observed in triglycerides to 1.7 mmol/L. Hence, a triple hypolipidaemic therapy facilitated the target LDL and triglyceride values without involving expensive medications like PCSK9 blockers. The patient’s mother also achieved the target basic lipidogram owing to a triple lipid-lowering therapy.Conclusion. The case is of interest to exemplify a successful triple lipid-lowering therapy in patients with familial hypercholesterolaemia.
{"title":"Triple-combined hypolipidaemic therapy in familial hypercholesterolaemia: clinical cases","authors":"S. Chepurnenko, G. Shavkuta, A. V. Safonova","doi":"10.25207/1608-6228-2021-28-5-117-130","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-117-130","url":null,"abstract":"Background. The prevalence of heterozygous familial hypercholesterolaemia (HeFH) comprises 1 per 250 people. The risk of premature cardiovascular disease (CVD) is 20 times higher in HeFH patients among the general population. CVD develops in HeFH patients under 20 years of age, and they usually do not survive to 30 years. Therefore, the primary treatment track here is correction of dyslipidaemia to prevent atherosclerosis progression and CVD. Clinical Case Descriptions. The article describes the clinical cases of familial dyslipidaemia in 47-yo patient M. and his 75-yo mother P. The patient had a visit related to blood pressure (BP) surges up to 140/90 mm Hg. In history: acute myocardial infarction (AMI) in maternal grandfather at 50 years and own uncle at 32 years. The patient’s cardiovascular risk factors: male gender, dyslipidaemia (total cholesterol (TC) 15.8 mmol/L), overweight (body mass index 29.9 kg/m2), familial history of young CVD, sedentary lifestyle (employed as manager), psychological and socioeconomic factors (work-related stress pressure), resting heart rate 88 beats/min. The patient was immediately ordered a combined hypolipidaemic therapy including rosuvastatin 20 mg, ezetimibe 10 mg, telmisartan 40 mg once daily for blood pressure correction. In 1-month therapy, cholesterol dropped to 4.4 mmol/L, low-density lipoprotein (LDL) cholesterol – to 2.2, but triglycerides remained high at 3.9 mmol/L. Fenofi brate added to therapy at 145 mg 1 time. Another 1-month therapy allowed the overall reduction of TC to 3.7, LDL cholesterol to 1.9, triglycerides to 2.17 and high-density lipoproteins to 1.19 mmol/L. Past 3 months, a further drop was observed in triglycerides to 1.7 mmol/L. Hence, a triple hypolipidaemic therapy facilitated the target LDL and triglyceride values without involving expensive medications like PCSK9 blockers. The patient’s mother also achieved the target basic lipidogram owing to a triple lipid-lowering therapy.Conclusion. The case is of interest to exemplify a successful triple lipid-lowering therapy in patients with familial hypercholesterolaemia.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44908035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-47-63
D. Dragunov, A. Sokolova, V. Mitrokhin, G. Arutyunov
Background. Salt intake currently poses a serious threat due to the cardiovascular challenge incurred by excessive sodium consumption.Objectives. The identification of markers associated with high salt intake in hypertensive patients.Methods. A retrospective observational case-control study surveyed 251 persons, including 194 hypertensive patients with stable salt intake. The intake was assessed in the “Charlton: SaltScreener” questionnaire. General, biochemical blood panels and interleukin levels (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18) were evaluated in the outcome of medical examination. Statistical data processing was performed with R using the RStudio software.Results. The mean patient age in survey was 72.47 ± 9.8 years, women prevailed in the selected cohort (n = 151, 60.1%). All patients were assigned in cohorts by the daily salt intake rate, ≤5 g (n = 12), 6–10 g (n = 144), >10 g salt per day (n = 38). The largest cohort (74.2%) united patients consuming 6–10 g salt per day, whereas only 6.2% patients consumed salt <5 g/day. Final analysis included patients consuming ≥6 g/day and having a C-reactive protein (CRP) level <20 mg/L. The analysis elicited an association between the monocyte count, CRP and salt intake towards the statement that higher salt intake leads to higher monocyte counts at CRP <20 mg/L in blood. Modelling revealed a close monocyte count–salt intake relationship, with a low-to-high intake transition sharply increasing the probability of elevated absolute monocyte count in blood provided the CRP level is <20 mg/L.Conclusion. The study infers a direct relationship between salt intake >10 g/day and blood monocyte count. However, its significance ceases at CRP rising to ≥20 mg/L.
{"title":"Impact of salt intake on inflammation markers in cardiovascular disease: a retrospective observational case-control study","authors":"D. Dragunov, A. Sokolova, V. Mitrokhin, G. Arutyunov","doi":"10.25207/1608-6228-2021-28-5-47-63","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-47-63","url":null,"abstract":"Background. Salt intake currently poses a serious threat due to the cardiovascular challenge incurred by excessive sodium consumption.Objectives. The identification of markers associated with high salt intake in hypertensive patients.Methods. A retrospective observational case-control study surveyed 251 persons, including 194 hypertensive patients with stable salt intake. The intake was assessed in the “Charlton: SaltScreener” questionnaire. General, biochemical blood panels and interleukin levels (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18) were evaluated in the outcome of medical examination. Statistical data processing was performed with R using the RStudio software.Results. The mean patient age in survey was 72.47 ± 9.8 years, women prevailed in the selected cohort (n = 151, 60.1%). All patients were assigned in cohorts by the daily salt intake rate, ≤5 g (n = 12), 6–10 g (n = 144), >10 g salt per day (n = 38). The largest cohort (74.2%) united patients consuming 6–10 g salt per day, whereas only 6.2% patients consumed salt <5 g/day. Final analysis included patients consuming ≥6 g/day and having a C-reactive protein (CRP) level <20 mg/L. The analysis elicited an association between the monocyte count, CRP and salt intake towards the statement that higher salt intake leads to higher monocyte counts at CRP <20 mg/L in blood. Modelling revealed a close monocyte count–salt intake relationship, with a low-to-high intake transition sharply increasing the probability of elevated absolute monocyte count in blood provided the CRP level is <20 mg/L.Conclusion. The study infers a direct relationship between salt intake >10 g/day and blood monocyte count. However, its significance ceases at CRP rising to ≥20 mg/L.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44292516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-29-46
A. Y. Barannikov, V. D. Sakhno, V. M. Durleshter, L. G. Izmailova, Andrei V. Andreev, E. V. Tokarenko
Background. Despite decreasing mortality in pancreaticoduodenal resection, the incidence of postoperative complications in such patients remains high. The choice and formation of “reliable” pancreatic-enteroanastomosis remain relevant.Objectives. The improvement of immediate surgery outcomes in pancreaticoduodenal resection via development of a differentiated algorithm for pancreatic-enteroanastomosis formation.Methods. A prospective non-randomised controlled trial enrolled 90 patients with a pancreaticoduodenal resection surgery. The patients were divided in three cohorts, A (n = 30), B (n = 30) and control C (n = 30). Pancreatic shear wave ultrasound elastography was conducted pre-surgery in main cohorts A and B. Average parenchymal stiffness and intraoperative data decided between the two pancreatico-enteric anastomosis techniques, end-to-side or the original pancreatic-enteroanastomosis. Control cohort C had pancreatico-enteric anastomosis without taking into account the pancreas stiffness and macrocondition.Results. Class A postoperative pancreatic fistula was registered in 2 (6.7%) of 30 patients in cohort B; it was transient, asymptomatic, not requiring additional treatment or a longer postoperative period. No class B and C pancreatic-enteroanastomosis failures or stump pancreonecroses were observed in main cohorts A and B. Clinically significant class B and C postoperative pancreatic fistulae were registered in 5 (16.7%) of 30 patients in control cohort C (inter-cohort comparison statistically significant).Conclusion. The proposed differentiated approach to pancreatic-enteroanastomosis formation associates with a reliably low postoperative complication frequency and lack of clinically significant class B and C postoperative pancreatic fistulae.
{"title":"Differentiated approach to pancreatic-enteroanastomosis in pancreaticoduodenal resection: a clinical experimental controlled trial","authors":"A. Y. Barannikov, V. D. Sakhno, V. M. Durleshter, L. G. Izmailova, Andrei V. Andreev, E. V. Tokarenko","doi":"10.25207/1608-6228-2021-28-5-29-46","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-29-46","url":null,"abstract":"Background. Despite decreasing mortality in pancreaticoduodenal resection, the incidence of postoperative complications in such patients remains high. The choice and formation of “reliable” pancreatic-enteroanastomosis remain relevant.Objectives. The improvement of immediate surgery outcomes in pancreaticoduodenal resection via development of a differentiated algorithm for pancreatic-enteroanastomosis formation.Methods. A prospective non-randomised controlled trial enrolled 90 patients with a pancreaticoduodenal resection surgery. The patients were divided in three cohorts, A (n = 30), B (n = 30) and control C (n = 30). Pancreatic shear wave ultrasound elastography was conducted pre-surgery in main cohorts A and B. Average parenchymal stiffness and intraoperative data decided between the two pancreatico-enteric anastomosis techniques, end-to-side or the original pancreatic-enteroanastomosis. Control cohort C had pancreatico-enteric anastomosis without taking into account the pancreas stiffness and macrocondition.Results. Class A postoperative pancreatic fistula was registered in 2 (6.7%) of 30 patients in cohort B; it was transient, asymptomatic, not requiring additional treatment or a longer postoperative period. No class B and C pancreatic-enteroanastomosis failures or stump pancreonecroses were observed in main cohorts A and B. Clinically significant class B and C postoperative pancreatic fistulae were registered in 5 (16.7%) of 30 patients in control cohort C (inter-cohort comparison statistically significant).Conclusion. The proposed differentiated approach to pancreatic-enteroanastomosis formation associates with a reliably low postoperative complication frequency and lack of clinically significant class B and C postoperative pancreatic fistulae.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47429431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-14-28
M. Avdeeva, M. I. Kulbuzheva, S. V. Zotov, Yelena V. Zhuravleva, A. V. Yatsukova
Background. The new coronavirus infection has manifested untypically compared to other acute respiratory agents, posing a major challenge to researchers worldwide. Despite low incidence of bacterial complications, microbial coinfection plays an important role in the onset and development of severe COVID-19 to hamper diagnosis, treatment and prognosis.Objectives. A study of microbial landscape in secondary complications of COVID-19 and prevailing microbial-agent antibiotic resistance dynamics in COVID-19 vs. patients with pre-COVID community-acquired pneumonia.Methods. We analysed 1,113 bacterial sputum cultures in COVID-19 patients from 21 hospital of Krasnodar Krai. The study sample comprised 524 strains isolated from COVID-19 patients in bacteriological assays. The comparison sample included 643 positive sputum strains isolated from community-acquired pneumonia patients developing disease in outcome of acute respiratory infection in 2015–2018. The microbial aetiology landscape and strain antibiotic resistance have been compared in COVID-19 vs. patients with community-acquired pneumonia.Results. Gram-negative bacteria predominated in COVID-19 cultures (58%), followed by Gram-positive bacteria (15%) and fungi (27%). Acinetobacter baumannii (35%) and Klebsiella pneumoniae (33%) were about equally represented in Gram-negative flora, Pseudomonas aeruginosa (19%) and other microorganisms were half as common. Streptococcus pneumonia and Staphylococcus aureus accounted for 48 and 15% Gram-positive strains, respectively. Sputum-isolated fungi were mainly identifi ed as Candida albicans (89%). The Streptoccocus pneumoniae detection rate dropped to 7% in 2020 relative of other flora, which is 10 times less vs. pre-COVID rates, whilst the fungal rate increased dramatically. Antibiotic resistance increased in most isolated microbial strains.Conclusion. A Gram-negative-dominated aetiology of lower respiratory tract lesions, as well as higher risk of fungal and other opportunistic coinfections should be taken into account in patient treatment for a complicated coronavirus infection. A higher antibiotic resistance is induced by active indication-ignorant use of antibiotics, including pre-hospital treatment. A suitable treatment regimen in COVID-19 should avoid undue antibiotic prescriptions in every patient.
{"title":"Microbial landscape in hospital patients with new coronavirus disease (COVID-19), antibiotic resistance comparison vs. Pre-covid stage: a prospective study","authors":"M. Avdeeva, M. I. Kulbuzheva, S. V. Zotov, Yelena V. Zhuravleva, A. V. Yatsukova","doi":"10.25207/1608-6228-2021-28-5-14-28","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-14-28","url":null,"abstract":"Background. The new coronavirus infection has manifested untypically compared to other acute respiratory agents, posing a major challenge to researchers worldwide. Despite low incidence of bacterial complications, microbial coinfection plays an important role in the onset and development of severe COVID-19 to hamper diagnosis, treatment and prognosis.Objectives. A study of microbial landscape in secondary complications of COVID-19 and prevailing microbial-agent antibiotic resistance dynamics in COVID-19 vs. patients with pre-COVID community-acquired pneumonia.Methods. We analysed 1,113 bacterial sputum cultures in COVID-19 patients from 21 hospital of Krasnodar Krai. The study sample comprised 524 strains isolated from COVID-19 patients in bacteriological assays. The comparison sample included 643 positive sputum strains isolated from community-acquired pneumonia patients developing disease in outcome of acute respiratory infection in 2015–2018. The microbial aetiology landscape and strain antibiotic resistance have been compared in COVID-19 vs. patients with community-acquired pneumonia.Results. Gram-negative bacteria predominated in COVID-19 cultures (58%), followed by Gram-positive bacteria (15%) and fungi (27%). Acinetobacter baumannii (35%) and Klebsiella pneumoniae (33%) were about equally represented in Gram-negative flora, Pseudomonas aeruginosa (19%) and other microorganisms were half as common. Streptococcus pneumonia and Staphylococcus aureus accounted for 48 and 15% Gram-positive strains, respectively. Sputum-isolated fungi were mainly identifi ed as Candida albicans (89%). The Streptoccocus pneumoniae detection rate dropped to 7% in 2020 relative of other flora, which is 10 times less vs. pre-COVID rates, whilst the fungal rate increased dramatically. Antibiotic resistance increased in most isolated microbial strains.Conclusion. A Gram-negative-dominated aetiology of lower respiratory tract lesions, as well as higher risk of fungal and other opportunistic coinfections should be taken into account in patient treatment for a complicated coronavirus infection. A higher antibiotic resistance is induced by active indication-ignorant use of antibiotics, including pre-hospital treatment. A suitable treatment regimen in COVID-19 should avoid undue antibiotic prescriptions in every patient.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42810897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-98-116
D. Dyachenko, S. Dyachenko
Background. The fi nite element method is gaining acknowledgment in Russia and other developed countries in a range of areas, including medicine. In stomatology, the method is applicable in research and implication of novel treatment and relevant material design.Objective. The review highlights usage of the fi nite element method in computer simulation to improve quality of patient dental care.Methods. The review analyses the state-of-the-art in current scientific literature. Records were mined in the PubMed and e-Library databases at a depth of 10 years, with selective inclusion of earlier articles. The query keywords were: finite element method [метод конечных элементов], computer simulation [компьютерная симуляция], quality of life improvement [повышение качества жизни], oral diseases [заболевания полости рта], dental treatment [стоматологическое лечение].Results. The review systematically surveys 56 scientific papers in the focus area for current state-of-the-art in the finite element analysis-empowered simulation in dentistry. The method’s rising employment is conditioned by its flexibility, 3D-object modelling simplicity and the rapid acquisition of reliable high-quality output. Its undoubted paramount advantage in dentistry is an explicit software visualisation of reliable results through co-modelling of multiple oral parameters.Conclusion. The growing acquaintance, mastering and use of this technique among researchers around the globe will give impetus to novel diagnosis and treatment, as well as relevant management algorithms in particular patient categories to enable personalisation of even mass dental check-up. This will reduce the number of visits, peri- and posttreatment error and complication rates for the improved patient’s quality of life and social rehabilitation.
{"title":"Finite element method in computer simulation for improved patient care in dentistry: A systematic review","authors":"D. Dyachenko, S. Dyachenko","doi":"10.25207/1608-6228-2021-28-5-98-116","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-98-116","url":null,"abstract":"Background. The fi nite element method is gaining acknowledgment in Russia and other developed countries in a range of areas, including medicine. In stomatology, the method is applicable in research and implication of novel treatment and relevant material design.Objective. The review highlights usage of the fi nite element method in computer simulation to improve quality of patient dental care.Methods. The review analyses the state-of-the-art in current scientific literature. Records were mined in the PubMed and e-Library databases at a depth of 10 years, with selective inclusion of earlier articles. The query keywords were: finite element method [метод конечных элементов], computer simulation [компьютерная симуляция], quality of life improvement [повышение качества жизни], oral diseases [заболевания полости рта], dental treatment [стоматологическое лечение].Results. The review systematically surveys 56 scientific papers in the focus area for current state-of-the-art in the finite element analysis-empowered simulation in dentistry. The method’s rising employment is conditioned by its flexibility, 3D-object modelling simplicity and the rapid acquisition of reliable high-quality output. Its undoubted paramount advantage in dentistry is an explicit software visualisation of reliable results through co-modelling of multiple oral parameters.Conclusion. The growing acquaintance, mastering and use of this technique among researchers around the globe will give impetus to novel diagnosis and treatment, as well as relevant management algorithms in particular patient categories to enable personalisation of even mass dental check-up. This will reduce the number of visits, peri- and posttreatment error and complication rates for the improved patient’s quality of life and social rehabilitation.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46918404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-64-78
G. Mogilnaya, E. V. Fomicheva
Background. A leading concept in modern regenerative medicine is the perspective of using own body resources to remodel organs and tissues via the formation of “living scaffold”. A pivotal role in the formation of dermal scaffold is played by fibroblasts that produce extracellular matrix (ECM).Aim. A study of the fibroblast activation mechanism mediating synthesis of the dermal ECM fibrillar component under the Facetem filler administration.Methods. The experimental trial was conducted in Wistar male rats (72 animals). Animals had 0.05 mL Facetem (Korea) injections subdermally. The filler is a calcium-containing product featuring gradual degradation delivered through structural microspheric properties of the Lattice-pore technology. Biological material was sampled at weeks 1 and 2 of months 1, 2, 3 and 5. Tissues were paraffin-embedded in standard histological assays and stained with Mallory’s trichrome, Picrosirius red in polarisation microscopy and immunohistochemistry with collagen types I, III and elastin antibodies (Abcam).Results. Collagen distribution in dermis and the filling zone suggests that collagen production occurs by week 2 of the Facetem filler placement followed by an increase in synthesised matrix volume to 4.39 ± 0.7 for collagen type I and 3.9 ± 0.2 for collagen type III (p < 0.05). The synthetic activity of fi broblasts reduces by month 3, albeit with collagen production remaining above control even by the end of month 5. Elastin synthesis also initiates by week 2 of the filler injection in dermis and grows by month 3.Conclusion. The presence of Facetem filler triggers a foreign body inflammatory response in dermis. This multifactorial process initiates with protein adsorption proceeding to dermal cell recruitment and modulation of fibroblasts and macrophages. Activation of these cell types induces neocollagenesis entailing the extracellular matrix synthesis and expansion in dermis.
背景现代再生医学的一个主要概念是利用自身的身体资源，通过形成“活支架”来重塑器官和组织。产生细胞外基质（ECM）的成纤维细胞在真皮支架的形成中发挥着关键作用。目的：研究在Facetem填充剂给药下，成纤维细胞活化介导真皮ECM原纤维成分合成的机制。方法。实验试验在Wistar雄性大鼠（72只动物）中进行。动物皮下注射0.05 mL Facetem（韩国）。填料是一种含钙产品，通过Lattice孔隙技术的结构微球特性逐渐降解。在第1、2、3和5个月的第1周和第2周对生物材料进行取样。将组织石蜡包埋在标准组织学测定中并在偏振显微镜下用Mallory三色染色、Picrosirius红染色以及用I型胶原进行免疫组织化学染色，III和弹性蛋白抗体（Abcam）。结果。真皮和填充区中的胶原分布表明，在Facetem填充物放置的第2周，胶原产生，随后合成基质体积增加到I型胶原的4.39±0.7和III型胶原的3.9±0.2（p<0.05）。成纤维细胞的合成活性在第3个月降低，尽管即使在第5个月结束时胶原生产仍保持在控制之上。在真皮中注射填充剂的第2周，弹性蛋白的合成也开始，并在第3个月生长。结论：Facetem填充剂的存在会引发真皮中的异物炎症反应。这一多因素过程始于蛋白质吸附，进而进行真皮细胞的募集和成纤维细胞和巨噬细胞的调节。这些细胞类型的激活诱导新胶原生成，这涉及真皮中细胞外基质的合成和扩张。
{"title":"Dermal extracellular matrix response to facetem implant: a randomised controlled experimental study","authors":"G. Mogilnaya, E. V. Fomicheva","doi":"10.25207/1608-6228-2021-28-5-64-78","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-64-78","url":null,"abstract":"Background. A leading concept in modern regenerative medicine is the perspective of using own body resources to remodel organs and tissues via the formation of “living scaffold”. A pivotal role in the formation of dermal scaffold is played by fibroblasts that produce extracellular matrix (ECM).Aim. A study of the fibroblast activation mechanism mediating synthesis of the dermal ECM fibrillar component under the Facetem filler administration.Methods. The experimental trial was conducted in Wistar male rats (72 animals). Animals had 0.05 mL Facetem (Korea) injections subdermally. The filler is a calcium-containing product featuring gradual degradation delivered through structural microspheric properties of the Lattice-pore technology. Biological material was sampled at weeks 1 and 2 of months 1, 2, 3 and 5. Tissues were paraffin-embedded in standard histological assays and stained with Mallory’s trichrome, Picrosirius red in polarisation microscopy and immunohistochemistry with collagen types I, III and elastin antibodies (Abcam).Results. Collagen distribution in dermis and the filling zone suggests that collagen production occurs by week 2 of the Facetem filler placement followed by an increase in synthesised matrix volume to 4.39 ± 0.7 for collagen type I and 3.9 ± 0.2 for collagen type III (p < 0.05). The synthetic activity of fi broblasts reduces by month 3, albeit with collagen production remaining above control even by the end of month 5. Elastin synthesis also initiates by week 2 of the filler injection in dermis and grows by month 3.Conclusion. The presence of Facetem filler triggers a foreign body inflammatory response in dermis. This multifactorial process initiates with protein adsorption proceeding to dermal cell recruitment and modulation of fibroblasts and macrophages. Activation of these cell types induces neocollagenesis entailing the extracellular matrix synthesis and expansion in dermis.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43594675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.25207/1608-6228-2021-28-5-79-97
I. N. Alekhin, N. S. Apkhanova, E. Dushina, Maria L. Prokopyeva
Background. Mental and behavioural disorders pose a pressing challenge in healthcare as pertaining to socially significant diseases. The significance is conditioned by high morbidity rates, including temporary and permanent disability, high fi nancial burden of medical care andregular social subsidy to target groups. According to the World Health Organisation, mental burden currently aggravates to entail serious social, human-rights and economic impact around the globe.Objectives. A study of regional dynamics of mental and behavioural morbidity in the Irkutsk Region over a seven-year period.Methods. A retrospective descriptive study used statistics data on primary and overall morbidity of definitely diagnosed mental and behavioural disorders (other than substance use disorders; F00–F09, F20–F99). The analysis of mental and behavioural illness incidence was based on statistical reports over the period of 2013–2019. The inclusion criterion was definite diagnosis of a mental and behavioural disorder (other than substance use disorder; F00–F09, F20–F99) in children, adolescents and adults. The main study indicators were the regional mental morbidity rate and prevalence, mental and behavioural morbidity rates among “dispensary care” and “medical counselling” outpatients, and primary morbidity rates by mental and behavioural nosology groups.Results. The article reports the regional traits of mental morbidity dynamics exhibiting a growing trend in Irkutsk Region. The morbidity traits of primary diagnoses have been analysed in dispensary care and medical counselling outpatients. Growing psychoneurologic visits are observed along with the institutional redirection of fi rst diagnoses towards decreasing the numbers of dispensary care vs. medical counselling outpatients. Thus, the structure of fi rst mental diagnoses changed towards prevailed medical counselling. Primary morbidity rate in male population is higher almost 1.5-fold in the study period. Primary morbidity elevated in both men and women. A primary morbidity analysis in different age cohorts reveals its growth in ages 0–14, 40–59 and >60 years.Conclusion. Our analyses reveal a lowering primary morbidity rate of mental disorders in outpatients taken for dispensary care, given the overall higher incidence. This may occur due to an institutional and instructional change in medical care provided to this patient category, including ineffective diagnosis, poor aid access and visit rate, statistical reporting design and possible changes in the criteria of taking for dispensary care. This fact requires improvements in the legal regulation of outpatient management of mental and behavioural illness at psychoneurologic institutions and the development of clear criteria of registering for dispensary care.
{"title":"Regional features of the incidence of mental disorders in the population (on the example of the Irkutsk region): a retrospective study","authors":"I. N. Alekhin, N. S. Apkhanova, E. Dushina, Maria L. Prokopyeva","doi":"10.25207/1608-6228-2021-28-5-79-97","DOIUrl":"https://doi.org/10.25207/1608-6228-2021-28-5-79-97","url":null,"abstract":"Background. Mental and behavioural disorders pose a pressing challenge in healthcare as pertaining to socially significant diseases. The significance is conditioned by high morbidity rates, including temporary and permanent disability, high fi nancial burden of medical care andregular social subsidy to target groups. According to the World Health Organisation, mental burden currently aggravates to entail serious social, human-rights and economic impact around the globe.Objectives. A study of regional dynamics of mental and behavioural morbidity in the Irkutsk Region over a seven-year period.Methods. A retrospective descriptive study used statistics data on primary and overall morbidity of definitely diagnosed mental and behavioural disorders (other than substance use disorders; F00–F09, F20–F99). The analysis of mental and behavioural illness incidence was based on statistical reports over the period of 2013–2019. The inclusion criterion was definite diagnosis of a mental and behavioural disorder (other than substance use disorder; F00–F09, F20–F99) in children, adolescents and adults. The main study indicators were the regional mental morbidity rate and prevalence, mental and behavioural morbidity rates among “dispensary care” and “medical counselling” outpatients, and primary morbidity rates by mental and behavioural nosology groups.Results. The article reports the regional traits of mental morbidity dynamics exhibiting a growing trend in Irkutsk Region. The morbidity traits of primary diagnoses have been analysed in dispensary care and medical counselling outpatients. Growing psychoneurologic visits are observed along with the institutional redirection of fi rst diagnoses towards decreasing the numbers of dispensary care vs. medical counselling outpatients. Thus, the structure of fi rst mental diagnoses changed towards prevailed medical counselling. Primary morbidity rate in male population is higher almost 1.5-fold in the study period. Primary morbidity elevated in both men and women. A primary morbidity analysis in different age cohorts reveals its growth in ages 0–14, 40–59 and >60 years.Conclusion. Our analyses reveal a lowering primary morbidity rate of mental disorders in outpatients taken for dispensary care, given the overall higher incidence. This may occur due to an institutional and instructional change in medical care provided to this patient category, including ineffective diagnosis, poor aid access and visit rate, statistical reporting design and possible changes in the criteria of taking for dispensary care. This fact requires improvements in the legal regulation of outpatient management of mental and behavioural illness at psychoneurologic institutions and the development of clear criteria of registering for dispensary care.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46303216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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