Pub Date : 2023-08-15DOI: 10.25207/1608-6228-2023-30-4-71-83
U. A. Shipieva, A. Adamchik, A. Gushchin, V. N. Samhaev, K. D. Kirsh, M. A. Adamchik, N. O. Risovannaya
Background. Polymer composites have good aesthetic characteristics and pronounced physicochemical properties, as compared to traditional restorative materials such as amalgam. However, the polymerization reaction of composite material containing bismethacrylate group commonly used in clinical practice is always accompanied by a different degree of volumetric shrinkage (2.7%~7.1%). The resulting stress can lead to adhesion failure and some other unfavorable clinical consequences, such as enamel destruction, microcracking of composite material and formation of microleakage between composite and tooth cavity wall, which can result in recurrent caries and postoperative sensitivity, thereby affecting the long-term effect of restoration. Therefore, studying the effect of preheating on composite restoration is important for its clinical application. Objective. To improve the effectiveness of treatment of patients with dental caries by improving the physicochemical properties of composite restorations.Methods. A randomized clinical trial enrolled 180 patients aged 18 to 45 years, diagnosed with dentin caries class I, according to Black (K02.1 in ICD). The study was conducted in the Dental Clinic of Kuban State Medical University, Russia. 180 composite restorations were performed in the treatment of dentin caries of molars. Patients were randomized into 2 groups): the control group — 90 patients and the main group — 90 patients. The control and main groups, in turn, were divided into three subgroups, depending on the composite used — Estelite Sigma Quick (Tokuyama Dental, Japan), Filtek Bulk Fill Posterior Restorative (3M Espe, USA) and DentLight (VladMiVa, Russia). Each subgroup consisted of 30 patients. In the control group, the classical method of filling with a composite material at “room temperature” was applied. In the main group, a composite heating conditioner “Ena Heat” (Micerium, Italy) was used to heat the composite to 55 °C before adapting the material in the formed cavity with subsequent photopolymerization. The quality of composite restorations within the clinical study was evaluated using the modified Ryge criterion immediately after treatment and after 6, 12, 18, 24 months. Statistical processing of the obtained data was carried out by means of one-factor analysis of variance using the GraphPadPrism 9 program (GraphPad Software, USA).Results. The duration of the clinical study comprised 24 months. The study revealed a statistically significant decrease in the quality of marginal fit of composite restorations (according to the Ryge score) by 20.1% (p = 0.0001) in the control group and by 5.7% (p = 0.0328) in the main group. At the same time, no statistically significant changes in Ryge scores were reported in the subgroups of composite materials of the main group (pF = 0.9480, pE = 0.1837, pD = 0.2529). As a result of the study, an optimal time algorithm (7 seconds) for using a special furnace for preheating the composite before sealing wi
{"title":"Clinical Justification for Preliminary Thermal Exposure to Composite in the Treatment of Caries: Randomized Clinical Trial","authors":"U. A. Shipieva, A. Adamchik, A. Gushchin, V. N. Samhaev, K. D. Kirsh, M. A. Adamchik, N. O. Risovannaya","doi":"10.25207/1608-6228-2023-30-4-71-83","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-4-71-83","url":null,"abstract":"Background. Polymer composites have good aesthetic characteristics and pronounced physicochemical properties, as compared to traditional restorative materials such as amalgam. However, the polymerization reaction of composite material containing bismethacrylate group commonly used in clinical practice is always accompanied by a different degree of volumetric shrinkage (2.7%~7.1%). The resulting stress can lead to adhesion failure and some other unfavorable clinical consequences, such as enamel destruction, microcracking of composite material and formation of microleakage between composite and tooth cavity wall, which can result in recurrent caries and postoperative sensitivity, thereby affecting the long-term effect of restoration. Therefore, studying the effect of preheating on composite restoration is important for its clinical application. Objective. To improve the effectiveness of treatment of patients with dental caries by improving the physicochemical properties of composite restorations.Methods. A randomized clinical trial enrolled 180 patients aged 18 to 45 years, diagnosed with dentin caries class I, according to Black (K02.1 in ICD). The study was conducted in the Dental Clinic of Kuban State Medical University, Russia. 180 composite restorations were performed in the treatment of dentin caries of molars. Patients were randomized into 2 groups): the control group — 90 patients and the main group — 90 patients. The control and main groups, in turn, were divided into three subgroups, depending on the composite used — Estelite Sigma Quick (Tokuyama Dental, Japan), Filtek Bulk Fill Posterior Restorative (3M Espe, USA) and DentLight (VladMiVa, Russia). Each subgroup consisted of 30 patients. In the control group, the classical method of filling with a composite material at “room temperature” was applied. In the main group, a composite heating conditioner “Ena Heat” (Micerium, Italy) was used to heat the composite to 55 °C before adapting the material in the formed cavity with subsequent photopolymerization. The quality of composite restorations within the clinical study was evaluated using the modified Ryge criterion immediately after treatment and after 6, 12, 18, 24 months. Statistical processing of the obtained data was carried out by means of one-factor analysis of variance using the GraphPadPrism 9 program (GraphPad Software, USA).Results. The duration of the clinical study comprised 24 months. The study revealed a statistically significant decrease in the quality of marginal fit of composite restorations (according to the Ryge score) by 20.1% (p = 0.0001) in the control group and by 5.7% (p = 0.0328) in the main group. At the same time, no statistically significant changes in Ryge scores were reported in the subgroups of composite materials of the main group (pF = 0.9480, pE = 0.1837, pD = 0.2529). As a result of the study, an optimal time algorithm (7 seconds) for using a special furnace for preheating the composite before sealing wi","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43618983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.25207/1608-6228-2023-30-4-37-47
N. A. Karpuk, S. Rubnikovich, I. V. Zhyltsov, O. C. Mazur, I. Karpuk, A. Mikhalenka
Background. The vast majority of malignant neoplasms of the oral mucosa refer to squamous cell carcinomas. The development of squamous cell carcinoma of the oral mucosa is often promoted by previous potentially malignant diseases, with oral leukoplakia dominating among them.Objective. To determine the clinical significance of the pathogenicity of somatic mutations in oral mucosal leukoplakia.Methods. The study material included 24 samples of abnormal epithelium of the oral mucosa from leukoplakia patients. QIAamp DNA FFPE Tissue Kit (Qiagen, Germany) was used for deoxyribonucleic acid (DNA) extraction from the samples. DNA sequencing was performed using IlluminaNextSeq 550 sequencer and TruSight™ Oncology 500 DNA Kit For Use with NextSeq (Illumina, USA). All DNA extractions from biological samples, preparation and sequencing of DNA libraries were performed step-by-step in strict accordance with the guidelines provided with the respective reagent kits. Bioinformatics analysis was carried out using specific software Illumina Base Space (Illumina, USA) and Galaxy Project (The Galaxy Community, a non-profit international project) according to current guidelines. The desired power of the study accounted for 90%. Two Proportions Z test was performed by means of The Sample Size Calculation of Statistica 12 (StatSoft, Inc.) with the set option “one-tailed hypothesis”, because it was initially assumed that pathogenic (oncogenic) genetic variants occur in the tissue of oral leukoplakia much more frequently than in the human reference genome used for sequence alignment.Results. The pathogenic somatic mutations in the TP53, KRAS, APC, NRAs and BRAF genes, identified in this study, alone or in combination, are highly likely (hazard ratio 3000-11000) to be associated with the development of oral mucosal leukoplakia and low-grade epithelial dysplasia. The multiplicity of pathogenic and likely pathogenic genetic variants associated with epithelial dysplasia, as well as the fact that a number of variants do not occur in all patients, suggests that the same histotype of oral mucosal dysplasia may develop under the influence of different mutations.Conclusion. The pathogenic and likely pathogenic variants of the TP53, KRAS, APC, NRAS and BRAF genes, identified in this study, alone or in combination, are highly likely (hazard ratio 3000–11000) to be associated with the development of leukoplakia and low-grade epithelial dysplasia.
背景绝大多数口腔粘膜恶性肿瘤是指鳞状细胞癌。口腔黏膜鳞状细胞癌的发展往往受到先前潜在恶性疾病的促进，其中口腔白斑占主导地位。客观的探讨口腔黏膜白斑体细胞突变致病性的临床意义。方法。研究材料包括24份白斑患者口腔粘膜异常上皮的样本。QIAamp DNA FFPE组织试剂盒（Qiagen，Germany）用于从样品中提取脱氧核糖核酸（DNA）。使用IlluminaNextSeq 550测序仪和TruSight进行DNA测序™ 与NextSeq一起使用的肿瘤学500 DNA试剂盒（Illumina，USA）。所有生物样品的DNA提取、DNA文库的制备和测序都是严格按照各自试剂盒提供的指南逐步进行的。根据现行指南，使用特定软件Illumina Base Space（Illumina，USA）和银河项目（银河社区，一个非营利国际项目）进行生物信息学分析。研究的期望功率占90%。两个比例Z检验是通过Statistica 12（StatSoft，股份有限公司）的样本量计算进行的，设置选项为“单尾假说”，因为最初假设致病（致癌）基因变异发生在口腔黏膜组织中的频率远高于用于序列比对的人类参考基因组。后果本研究中单独或联合鉴定的TP53、KRAS、APC、NRAs和BRAF基因的致病性体细胞突变极有可能（危险比3000-11000）与口腔粘膜白斑和低度上皮发育不良的发展有关。与上皮发育不良相关的致病性和可能致病性遗传变异的多样性，以及并非所有患者都会出现许多变异的事实，表明相同组织类型的口腔粘膜发育不良可能在不同突变的影响下发展。结论本研究中单独或联合鉴定的TP53、KRAS、APC、NRAS和BRAF基因的致病性和可能的致病性变体极有可能（危险比3000-11000）与白斑和低度上皮发育不良的发展有关。
{"title":"Clinical Significance of Pathogenicity of Somatic Mutations in Oral Leukoplakia: a Prospective Observational Study","authors":"N. A. Karpuk, S. Rubnikovich, I. V. Zhyltsov, O. C. Mazur, I. Karpuk, A. Mikhalenka","doi":"10.25207/1608-6228-2023-30-4-37-47","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-4-37-47","url":null,"abstract":"Background. The vast majority of malignant neoplasms of the oral mucosa refer to squamous cell carcinomas. The development of squamous cell carcinoma of the oral mucosa is often promoted by previous potentially malignant diseases, with oral leukoplakia dominating among them.Objective. To determine the clinical significance of the pathogenicity of somatic mutations in oral mucosal leukoplakia.Methods. The study material included 24 samples of abnormal epithelium of the oral mucosa from leukoplakia patients. QIAamp DNA FFPE Tissue Kit (Qiagen, Germany) was used for deoxyribonucleic acid (DNA) extraction from the samples. DNA sequencing was performed using IlluminaNextSeq 550 sequencer and TruSight™ Oncology 500 DNA Kit For Use with NextSeq (Illumina, USA). All DNA extractions from biological samples, preparation and sequencing of DNA libraries were performed step-by-step in strict accordance with the guidelines provided with the respective reagent kits. Bioinformatics analysis was carried out using specific software Illumina Base Space (Illumina, USA) and Galaxy Project (The Galaxy Community, a non-profit international project) according to current guidelines. The desired power of the study accounted for 90%. Two Proportions Z test was performed by means of The Sample Size Calculation of Statistica 12 (StatSoft, Inc.) with the set option “one-tailed hypothesis”, because it was initially assumed that pathogenic (oncogenic) genetic variants occur in the tissue of oral leukoplakia much more frequently than in the human reference genome used for sequence alignment.Results. The pathogenic somatic mutations in the TP53, KRAS, APC, NRAs and BRAF genes, identified in this study, alone or in combination, are highly likely (hazard ratio 3000-11000) to be associated with the development of oral mucosal leukoplakia and low-grade epithelial dysplasia. The multiplicity of pathogenic and likely pathogenic genetic variants associated with epithelial dysplasia, as well as the fact that a number of variants do not occur in all patients, suggests that the same histotype of oral mucosal dysplasia may develop under the influence of different mutations.Conclusion. The pathogenic and likely pathogenic variants of the TP53, KRAS, APC, NRAS and BRAF genes, identified in this study, alone or in combination, are highly likely (hazard ratio 3000–11000) to be associated with the development of leukoplakia and low-grade epithelial dysplasia.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42852383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.25207/1608-6228-2023-30-4-28-36
V. R. Gabidullina, A. Tsitsiashvili, A. V. Zaborovsky, I. Ostrovskaya, K. G. Gurevich
Background. The available comparative studies on issues of choosing antibiotic regimen in dental implantation are often observational and describe only visible postoperative signs. More objective assessment of postoperative period and comparison of approaches requires laboratory tests. One of the methods to be used at a dental appointment is to study examination of the biochemical properties of saliva.Objective. To carry out comparative evaluation of single and prolonged regimens of amoxicillin/clavulanate administration after dental implantation indicated by nonspecific immunity in mixed saliva.Methods. A randomized uncontrolled trial of 30 partially edentulous patients was conducted. The clinical phase of the study was performed at the Department of Propaedeutics of Surgical Dentistry, MSUMD; the laboratory phase — at the Pharmacology and Biological Chemistry Departments, MSUMD, in 2021–2022. The study included patients aged 18 to 75 years, anatomically suitable for dental implant placement. Patients with somatic diseases in the decompensation stage were excluded from the study. Patients were randomized into 2 groups. The group 1 was prescribed to take amoxicillin/clavulanate pills (875+125 mg) 30 minutes before surgery. The group 2 was to take amoxicillin/clavulanate (875+125 mg) 30 minutes before surgery and then 1 pill of Amoxicillin/ Clavulanate (500+125 mg) 2 times a day for 7 days after surgery. To evaluate the efficacy of the applied antibiotic therapy, unstimulated mixed saliva was collected from all patients on an empty stomach, 1 ml before surgery and on the third day after surgery. The amount of immunoglobulins of G, M, A classes (mg/l) and б-amylase activity (IU/l) were determined spectrophotometrically in the saliva samples. Statistical processing of laboratory data was performed using Welch's t-test by means of Statistica 10 Pro (StatSoft, USA). Intergroup and intragroup differences were considered significant at p ≤ 0.05.Results. Based on the saliva proteins examined, the most pronounced difference between the patient groups was obtained for IgA. For other studied parameters of saliva, no significant difference between the groups was obtained on the third day after the surgery. However, despite the absence of a statistical difference, a tendency to a stronger increase in the amount of IgA, G, IgM, salivary amylase activity was noted for all indicators; moreover, a high correlation between immunoglobulins of class A, G, immunoglobulins of class G, M, and immunoglobulins of class A, M was revealed.Conclusion. Among patients with the prolonged regimen, the groups did not differ significantly in such saliva parameters as immunoglobulins G and M and salivary б-amylase activity, however, a tendency to a stronger increase of the mentioned immunoglobulins in the saliva of group 1 patients was revealed. The most significant difference was recorded for immunoglobulin A in saliva, the amount of which was significantly lower in the group of
{"title":"Efficacy of Various Regimens of Inhibitor-Protected Penicillins on the Basis of Immunospecific Mixed Saliva Proteins in Patients after Dental Implantation: a Randomized Uncontrolled Trial","authors":"V. R. Gabidullina, A. Tsitsiashvili, A. V. Zaborovsky, I. Ostrovskaya, K. G. Gurevich","doi":"10.25207/1608-6228-2023-30-4-28-36","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-4-28-36","url":null,"abstract":"Background. The available comparative studies on issues of choosing antibiotic regimen in dental implantation are often observational and describe only visible postoperative signs. More objective assessment of postoperative period and comparison of approaches requires laboratory tests. One of the methods to be used at a dental appointment is to study examination of the biochemical properties of saliva.Objective. To carry out comparative evaluation of single and prolonged regimens of amoxicillin/clavulanate administration after dental implantation indicated by nonspecific immunity in mixed saliva.Methods. A randomized uncontrolled trial of 30 partially edentulous patients was conducted. The clinical phase of the study was performed at the Department of Propaedeutics of Surgical Dentistry, MSUMD; the laboratory phase — at the Pharmacology and Biological Chemistry Departments, MSUMD, in 2021–2022. The study included patients aged 18 to 75 years, anatomically suitable for dental implant placement. Patients with somatic diseases in the decompensation stage were excluded from the study. Patients were randomized into 2 groups. The group 1 was prescribed to take amoxicillin/clavulanate pills (875+125 mg) 30 minutes before surgery. The group 2 was to take amoxicillin/clavulanate (875+125 mg) 30 minutes before surgery and then 1 pill of Amoxicillin/ Clavulanate (500+125 mg) 2 times a day for 7 days after surgery. To evaluate the efficacy of the applied antibiotic therapy, unstimulated mixed saliva was collected from all patients on an empty stomach, 1 ml before surgery and on the third day after surgery. The amount of immunoglobulins of G, M, A classes (mg/l) and б-amylase activity (IU/l) were determined spectrophotometrically in the saliva samples. Statistical processing of laboratory data was performed using Welch's t-test by means of Statistica 10 Pro (StatSoft, USA). Intergroup and intragroup differences were considered significant at p ≤ 0.05.Results. Based on the saliva proteins examined, the most pronounced difference between the patient groups was obtained for IgA. For other studied parameters of saliva, no significant difference between the groups was obtained on the third day after the surgery. However, despite the absence of a statistical difference, a tendency to a stronger increase in the amount of IgA, G, IgM, salivary amylase activity was noted for all indicators; moreover, a high correlation between immunoglobulins of class A, G, immunoglobulins of class G, M, and immunoglobulins of class A, M was revealed.Conclusion. Among patients with the prolonged regimen, the groups did not differ significantly in such saliva parameters as immunoglobulins G and M and salivary б-amylase activity, however, a tendency to a stronger increase of the mentioned immunoglobulins in the saliva of group 1 patients was revealed. The most significant difference was recorded for immunoglobulin A in saliva, the amount of which was significantly lower in the group of ","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42440804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-15DOI: 10.25207/1608-6228-2023-30-4-84-95
E. A. Durnovo, V. Tarakanova, M. Shakhova, P. Peretyagin, S. A. Durnovo
Background. Healing of open wounds in the oral cavity is often accompanied by infection and constant traumatization, which lead to impaired blood supply to the tissues, lack of trophic support and low oxygen supply to increasing proliferative processes. Recently, photodynamic therapy has taken its place among the methods for stimulating regeneration of oral mucosal tissues. The authors consider it essential to study the influence of photodynamic treatment on the functional state of the microvasculature in the wound tissues, which determines the transcapillary exchange and the tissue respiration, providing the tissue regeneration.Objective. To study the photodynamic effect of sequential dual-wavelength radiation on the microvasculature in the wound tissues of the oral mucosa in vivo.Methods. The study was carried out on 36 female outbred Wistar rats, weighing 200–250 g. The animals were divided into two groups: control group (n = 18) and experimental group (n = 18). Wound surfaces healed by secondary intention were modeled on the cheek mucosa of the animals. Dual-wavelength photodynamic therapy was performed in the 1st postoperative day in experimental group. The microcirculatory function was assessed by Doppler flowmetry before, and on days 3, 7 and 14 after wounding. The results were processed using IBM SPSS Statistics 26.0.0.1 (IBM Inc., USA).Results. It has been established that dual-wavelength photodynamic therapy has a positive effect on the restoration of the microvasculature of the wound tissues. This therapy facilitated bypassing for microcirculatory flow on the 3rd day of the study, and increased the perfusion of tissues on the 7th. The experimental group did not have congestive-ischaemic phenomena in the wound region; the microcirculatory flow was augmented through the microcirculation regulation by the 14th day.Conclusion. Following the obtained results the use of dual-wavelength photodynamic therapy can be considered as a promising method for restoration of the microvasculature of tissues in the oral mucosal trauma.
{"title":"Examination of the Microvasculature During Wound Process of the Oral Mucosa when Using Dual-Wavelength Photodynamic Therapy: a Pre-Clinical Experimental Randomized Study","authors":"E. A. Durnovo, V. Tarakanova, M. Shakhova, P. Peretyagin, S. A. Durnovo","doi":"10.25207/1608-6228-2023-30-4-84-95","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-4-84-95","url":null,"abstract":"Background. Healing of open wounds in the oral cavity is often accompanied by infection and constant traumatization, which lead to impaired blood supply to the tissues, lack of trophic support and low oxygen supply to increasing proliferative processes. Recently, photodynamic therapy has taken its place among the methods for stimulating regeneration of oral mucosal tissues. The authors consider it essential to study the influence of photodynamic treatment on the functional state of the microvasculature in the wound tissues, which determines the transcapillary exchange and the tissue respiration, providing the tissue regeneration.Objective. To study the photodynamic effect of sequential dual-wavelength radiation on the microvasculature in the wound tissues of the oral mucosa in vivo.Methods. The study was carried out on 36 female outbred Wistar rats, weighing 200–250 g. The animals were divided into two groups: control group (n = 18) and experimental group (n = 18). Wound surfaces healed by secondary intention were modeled on the cheek mucosa of the animals. Dual-wavelength photodynamic therapy was performed in the 1st postoperative day in experimental group. The microcirculatory function was assessed by Doppler flowmetry before, and on days 3, 7 and 14 after wounding. The results were processed using IBM SPSS Statistics 26.0.0.1 (IBM Inc., USA).Results. It has been established that dual-wavelength photodynamic therapy has a positive effect on the restoration of the microvasculature of the wound tissues. This therapy facilitated bypassing for microcirculatory flow on the 3rd day of the study, and increased the perfusion of tissues on the 7th. The experimental group did not have congestive-ischaemic phenomena in the wound region; the microcirculatory flow was augmented through the microcirculation regulation by the 14th day.Conclusion. Following the obtained results the use of dual-wavelength photodynamic therapy can be considered as a promising method for restoration of the microvasculature of tissues in the oral mucosal trauma.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49582158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-14DOI: 10.25207/1608-6228-2023-30-5-113-123
N. V. Tomchik, T. A. Lashkovskaya, A. I. Kizilevich, A. I. Matveichyk
Background. Acute coronary syndrome is widespread in the adult population and has clear diagnostic criteria. In pediatric practice, this pathology is rare, and often implies difficulties in diagnosis. Case description . A 16-year-old male with negative paternal history, hypercholesterolemia, dyslipidemia, and excessive body weight developed myocardial infarction on the background of acute tonsillitis. In the onset of the disease, the adolescent demonstrated clinical signs of acute respiratory infection and coronary spasm. Electrocardiogram revealed ST segment elevation above the baseline in leads I, II, III, aVF, V4–V6 and biochemical markers of myocardial necrosis. Echocardiography revealed signs of focal hypokinesis of the left ventricle, newly detected degree 2 mitral regurgitation. Percutaneous coronary angiography revealed no signs of coronary artery stenosis. The patient received conventional medical treatment of acute myocardial infarction as well as antibacterial therapy. He was discharged in satisfactory condition. After 1 year of follow-up after the myocardial infarction the patient showed no pathologic changes both on stress-echocardiography and electrocardiogram. Three-year catamnesis appeared to be favorable. Conclusion. The presented clinical case demonstrates the individual mechanism of acute coronary syndrome development in children. Pediatricians should be aware of the risk of developing acute coronary syndrome against the background of infectious pathology.
{"title":"Acute coronary syndrome as a current issue of pediatric cardiology. Outcomes and prognosis: Clinical case","authors":"N. V. Tomchik, T. A. Lashkovskaya, A. I. Kizilevich, A. I. Matveichyk","doi":"10.25207/1608-6228-2023-30-5-113-123","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-5-113-123","url":null,"abstract":"Background. Acute coronary syndrome is widespread in the adult population and has clear diagnostic criteria. In pediatric practice, this pathology is rare, and often implies difficulties in diagnosis. Case description . A 16-year-old male with negative paternal history, hypercholesterolemia, dyslipidemia, and excessive body weight developed myocardial infarction on the background of acute tonsillitis. In the onset of the disease, the adolescent demonstrated clinical signs of acute respiratory infection and coronary spasm. Electrocardiogram revealed ST segment elevation above the baseline in leads I, II, III, aVF, V4–V6 and biochemical markers of myocardial necrosis. Echocardiography revealed signs of focal hypokinesis of the left ventricle, newly detected degree 2 mitral regurgitation. Percutaneous coronary angiography revealed no signs of coronary artery stenosis. The patient received conventional medical treatment of acute myocardial infarction as well as antibacterial therapy. He was discharged in satisfactory condition. After 1 year of follow-up after the myocardial infarction the patient showed no pathologic changes both on stress-echocardiography and electrocardiogram. Three-year catamnesis appeared to be favorable. Conclusion. The presented clinical case demonstrates the individual mechanism of acute coronary syndrome development in children. Pediatricians should be aware of the risk of developing acute coronary syndrome against the background of infectious pathology.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135308109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-12DOI: 10.25207/1608-6228-2023-30-4-96-109
A. V. Gus’kov, S. A. Mashutin, A. Oleinikov, M. K. Zainutdinov, E. A. Klimenko, L. Toropova
Background. Rehabilitation of patients with chronic periodontal diseases leading to multiple tooth loss can be carried out using the method of immediate prosthetics. However, the likelihood of atrophy of denture-supporting tissues under non-physiological load with removable dental prostheses imposes special requirements for their design features.Case description. Two patients seeking for dental surgical and prosthetic treatment for the diagnosis of chronic generalized periodontitis were treated in the dental clinic of Ryazan State Medical University named after academician I.P. Pavlov. Patient A. was mounted immediate prostheses made using additive technologies with the original design of the drug reservoir. Patient B. was mounted immediate prostheses with bases made of acrylic plastic, border ring of elastic polymer, and a drug reservoir made of polymethyl methacrylate. Patients underwent tooth extraction with immediate prosthetics. Patients were followed for 21 days. Criteria for the effectiveness of treatment included visual and palpatory control of extraction sites with a planimetric wound size analysis, assessment of microcirculation at the extraction site, control of the drug persistence in the reservoirs of prostheses.Conclusion. The observations at the stages of prosthodontic treatment revealed that immediate prostheses made with the help of 3D modeling and printing technologies resulted in a normal course of healing after tooth extraction with the normalization of microcirculatory parameters at the surgical wound sites. When using combined prosthetic structures, healing of postoperative wounds also proceeded favorably, however, congestion in the microcirculatory system was noted.
{"title":"Evaluating the Effectiveness of the Original Designs of Immediate-Prostheses after Multiple Tooth Extraction: Clinical Cases","authors":"A. V. Gus’kov, S. A. Mashutin, A. Oleinikov, M. K. Zainutdinov, E. A. Klimenko, L. Toropova","doi":"10.25207/1608-6228-2023-30-4-96-109","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-4-96-109","url":null,"abstract":"Background. Rehabilitation of patients with chronic periodontal diseases leading to multiple tooth loss can be carried out using the method of immediate prosthetics. However, the likelihood of atrophy of denture-supporting tissues under non-physiological load with removable dental prostheses imposes special requirements for their design features.Case description. Two patients seeking for dental surgical and prosthetic treatment for the diagnosis of chronic generalized periodontitis were treated in the dental clinic of Ryazan State Medical University named after academician I.P. Pavlov. Patient A. was mounted immediate prostheses made using additive technologies with the original design of the drug reservoir. Patient B. was mounted immediate prostheses with bases made of acrylic plastic, border ring of elastic polymer, and a drug reservoir made of polymethyl methacrylate. Patients underwent tooth extraction with immediate prosthetics. Patients were followed for 21 days. Criteria for the effectiveness of treatment included visual and palpatory control of extraction sites with a planimetric wound size analysis, assessment of microcirculation at the extraction site, control of the drug persistence in the reservoirs of prostheses.Conclusion. The observations at the stages of prosthodontic treatment revealed that immediate prostheses made with the help of 3D modeling and printing technologies resulted in a normal course of healing after tooth extraction with the normalization of microcirculatory parameters at the surgical wound sites. When using combined prosthetic structures, healing of postoperative wounds also proceeded favorably, however, congestion in the microcirculatory system was noted.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49118683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.25207/1608-6228-2023-30-4-48-60
Y. Makedonova, L. Gavrikova, S. Dyachenko, D. Dyachenko
Background. Effective treatment of oral candidiasis is especially relevant due to the increase in patients with recurrent fungal lesions of the oral cavity caused by the growing number of Candidaspp. strains refractory to antimycotic drugs. The paper presents the results of the study on the clinical efficacy of etiotropic therapy in patients with chronic recurrent course of oral candidiasis.Objective. To assess the effectiveness of etiotropic therapy in patients with chronic recurrent oral candidiasis.Methods. A randomized controlled clinical trial was conducted in 56 patients with chronic recurrent oral candidiasis aged 45 to 74 years. Examination and treatment of patients was performed at the Department of Dentistry of Volgograd State Medical University and at Volgograd Regional Clinical Dental Polyclinic (Volgograd, Russia). Study timeline: September 2020 — November 2022. Patients were divided into 2 groups depending on the antimycotic drug used: in the main group, patients took voriconazole, in the control group — fluconazole. In addition to etiotropic therapy, patients of both groups were prescribed complex treatment aimed at stimulating the immune protection of the body, restoring vitamin and mineral deficiency, and correcting the imbalance of the oral ecosystem. The patients underwent local symptomatic therapy: antiseptic treatment with 0.06% chlorhexidine bigluconate solution, anesthesia with 15% lidocaine gel, and 3.44% retinol oil solution to stimulate epithelization. Oral sanitation and professional hygiene were recommended for patients to prevent oral candidiasis. In order to restore chewing function, patients were referred to prosthodontic treatment. The main reference point of the study was to assess the effectiveness of the therapy, both by clinical criteria and by evaluating the results of bacterial culture test in order to record the quantitative, species and susceptibility profile of Candidaspp. strains in 3 weeks, 6 and 12 months after the end of treatment. Analysis and statistical processing of the obtained data were performed using Excel program to MS Windows 10 (Microsoft Corp., USA).Results. The most common pathogenic agent of chronic recurrent forms of oral candidiasis is C. albicans (69.6%), followed by C. non-albicans species — C. krusei (10.7%), C. tropicalis (10.7%) and C. glabrata (8.9%). Analysis of the quantitative characteristics of Candidaspp. using bacterial culture test revealed a high and moderate number of Candidaspp. CFU in most clinical isolates before treatment, and no such cases in patients of the main group after treatment. The susceptibility test of yeast fungi to fluconazole and itraconazole showed the presence of isolates with dose-dependent susceptibility, and the resistance of individual samples C. krusei to fluconazole and C. glabrata (16.7% and 60%, respectively) and to itraconazole (33.3% and 100%, respectively). All Candidaspp. isolates were found to be highly susceptible to voriconazole. The eff
{"title":"Effiectiveness of Etiotropic Therapy in Patients with Chronic Recurrent Oral Candidiasis: a Randomized Controlled Clinical Trial","authors":"Y. Makedonova, L. Gavrikova, S. Dyachenko, D. Dyachenko","doi":"10.25207/1608-6228-2023-30-4-48-60","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-4-48-60","url":null,"abstract":"Background. Effective treatment of oral candidiasis is especially relevant due to the increase in patients with recurrent fungal lesions of the oral cavity caused by the growing number of Candidaspp. strains refractory to antimycotic drugs. The paper presents the results of the study on the clinical efficacy of etiotropic therapy in patients with chronic recurrent course of oral candidiasis.Objective. To assess the effectiveness of etiotropic therapy in patients with chronic recurrent oral candidiasis.Methods. A randomized controlled clinical trial was conducted in 56 patients with chronic recurrent oral candidiasis aged 45 to 74 years. Examination and treatment of patients was performed at the Department of Dentistry of Volgograd State Medical University and at Volgograd Regional Clinical Dental Polyclinic (Volgograd, Russia). Study timeline: September 2020 — November 2022. Patients were divided into 2 groups depending on the antimycotic drug used: in the main group, patients took voriconazole, in the control group — fluconazole. In addition to etiotropic therapy, patients of both groups were prescribed complex treatment aimed at stimulating the immune protection of the body, restoring vitamin and mineral deficiency, and correcting the imbalance of the oral ecosystem. The patients underwent local symptomatic therapy: antiseptic treatment with 0.06% chlorhexidine bigluconate solution, anesthesia with 15% lidocaine gel, and 3.44% retinol oil solution to stimulate epithelization. Oral sanitation and professional hygiene were recommended for patients to prevent oral candidiasis. In order to restore chewing function, patients were referred to prosthodontic treatment. The main reference point of the study was to assess the effectiveness of the therapy, both by clinical criteria and by evaluating the results of bacterial culture test in order to record the quantitative, species and susceptibility profile of Candidaspp. strains in 3 weeks, 6 and 12 months after the end of treatment. Analysis and statistical processing of the obtained data were performed using Excel program to MS Windows 10 (Microsoft Corp., USA).Results. The most common pathogenic agent of chronic recurrent forms of oral candidiasis is C. albicans (69.6%), followed by C. non-albicans species — C. krusei (10.7%), C. tropicalis (10.7%) and C. glabrata (8.9%). Analysis of the quantitative characteristics of Candidaspp. using bacterial culture test revealed a high and moderate number of Candidaspp. CFU in most clinical isolates before treatment, and no such cases in patients of the main group after treatment. The susceptibility test of yeast fungi to fluconazole and itraconazole showed the presence of isolates with dose-dependent susceptibility, and the resistance of individual samples C. krusei to fluconazole and C. glabrata (16.7% and 60%, respectively) and to itraconazole (33.3% and 100%, respectively). All Candidaspp. isolates were found to be highly susceptible to voriconazole. The eff","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47174433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-22DOI: 10.25207/1608-6228-2023-30-3-76-84
I. A. Chastoyedova
Background. Hemodynamic parameters are interrelated with both the threshold of salt sensitivity and the type of initial autonomic tone. Available data on such relationships are insufficient. Objective — to identify the hemodynamic parameters and features in students with different thresholds of salt sensitivity and types of autonomic tone.Methods. The study enrolled 174 second-year students of Kirov State Medical University, aged 18–23, who gave consent to the survey. The study was conducted over a period of four months and included two stages. At the first stage, all participants were evaluated for the threshold of salt sensitivity. According to the results, two groups were formed: group A — students with a normal threshold of salt sensitivity (n = 127); group B — students with a high threshold of salt sensitivity (n = 39). In the formed groups, a comparative analysis of hemodynamic parameters was carried out. At the second stage of the study, after assessing the initial autonomic tone, three groups were identified: group 1 (n = 40) — students with equilibrium of the sympathetic and parasympathetic systems (normotension); group 2 (n = 104) — students with dominating parasympathetic regulation of the heart rhythm (vagotonia); group 3 (n = 22) — students with dominating sympathetic regulation of the heart rhythm (sympathicotonia). Hemodynamic parameters were also studied in these groups. Statistical data processing was carried out using Statistica Advanced 10 for Windows RU. The differences between the comparison groups were assessed using parametric Student’s t-test and non-parametric Mann-Whitney U-test.Results. A high threshold of salt sensitivity was revealed in 23% of students. When comparing hemodynamic parameters in the groups, it was found that students with high thresholds of salt sensitivity had significantly higher values of systolic blood pressure, diastolic blood pressure, pulse pressure and average hemodynamic pressure than students with a low threshold. Differences in hemodynamics in students may be caused by differences in the original autonomic tone. Thus, students with vagotonia, if compared to those with normotension, have significantly lower values of heart rate, cardiac minute output, double product, and circulatory efficiency ratio, but a higher value of the peripheral vascular resistance. Students with sympathicotonia have statistically higher heart rate, cardiac minute output, and double product values.Conclusion. The assessment of hemodynamic parameters in healthy young people in relation to the threshold of salt sensitivity and the initial autonomic tone enables the risk factors for the development of hypertension to be assessed, prehypertension (high normal blood pressure) to be identified, and preventive programs aimed at reducing the number of diseases of the cardiovascular system to be developed.
背景血液动力学参数与盐敏感性阈值和初始自主神经张力类型相关。关于这种关系的现有数据不足。目的：确定不同盐敏感性阈值和自主神经张力类型的学生的血液动力学参数和特征。方法。这项研究招募了基洛夫州立医科大学174名二年级学生，年龄在18-23岁之间，他们同意这项调查。这项研究历时四个月，包括两个阶段。在第一阶段，对所有参与者的盐敏感性阈值进行评估。根据结果，分为两组：A组——盐敏阈值正常的学生（n=127）；B组——具有高盐敏感性阈值的学生（n=39）。在形成的组中，对血液动力学参数进行比较分析。在研究的第二阶段，在评估了最初的自主神经张力后，确定了三组：第1组（n=40）——交感神经和副交感神经系统平衡的学生（血压正常）；第2组（n=104）——具有支配性副交感神经调节心律的学生（迷走神经缺乏症）；第3组（n=22）——具有支配性交感神经调节心律的学生（交感神经强直）。还对这些组的血液动力学参数进行了研究。使用Statistica Advanced 10 for Windows RU进行统计数据处理。使用参数Student t检验和非参数Mann-Whitney U检验评估比较组之间的差异。结果。23%的学生出现高盐敏感性阈值。在比较各组的血液动力学参数时，发现盐敏感性阈值高的学生的收缩压、舒张压、脉压和平均血液动力学压力值明显高于阈值低的学生。学生血流动力学的差异可能是由原始自主神经音调的差异引起的。因此，与血压正常的学生相比，迷走神经缺乏的学生的心率、每分钟输出量、双乘积和循环效率比明显较低，但外周血管阻力值较高。从统计数据来看，患有交感神经痛的学生心率、每分钟心输出量和双乘积值较高。结论通过评估健康年轻人的血液动力学参数与盐敏感性阈值和初始自主神经张力的关系，可以评估高血压发展的风险因素，确定高血压前期（正常血压高），并制定旨在减少心血管系统疾病数量的预防计划。
{"title":"Hemodynamic Parameters in Students with Different Thresholds of Salt Sensitivity and Type of Autonomic Tone: An Observational Cohort Study","authors":"I. A. Chastoyedova","doi":"10.25207/1608-6228-2023-30-3-76-84","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-3-76-84","url":null,"abstract":"Background. Hemodynamic parameters are interrelated with both the threshold of salt sensitivity and the type of initial autonomic tone. Available data on such relationships are insufficient. Objective — to identify the hemodynamic parameters and features in students with different thresholds of salt sensitivity and types of autonomic tone.Methods. The study enrolled 174 second-year students of Kirov State Medical University, aged 18–23, who gave consent to the survey. The study was conducted over a period of four months and included two stages. At the first stage, all participants were evaluated for the threshold of salt sensitivity. According to the results, two groups were formed: group A — students with a normal threshold of salt sensitivity (n = 127); group B — students with a high threshold of salt sensitivity (n = 39). In the formed groups, a comparative analysis of hemodynamic parameters was carried out. At the second stage of the study, after assessing the initial autonomic tone, three groups were identified: group 1 (n = 40) — students with equilibrium of the sympathetic and parasympathetic systems (normotension); group 2 (n = 104) — students with dominating parasympathetic regulation of the heart rhythm (vagotonia); group 3 (n = 22) — students with dominating sympathetic regulation of the heart rhythm (sympathicotonia). Hemodynamic parameters were also studied in these groups. Statistical data processing was carried out using Statistica Advanced 10 for Windows RU. The differences between the comparison groups were assessed using parametric Student’s t-test and non-parametric Mann-Whitney U-test.Results. A high threshold of salt sensitivity was revealed in 23% of students. When comparing hemodynamic parameters in the groups, it was found that students with high thresholds of salt sensitivity had significantly higher values of systolic blood pressure, diastolic blood pressure, pulse pressure and average hemodynamic pressure than students with a low threshold. Differences in hemodynamics in students may be caused by differences in the original autonomic tone. Thus, students with vagotonia, if compared to those with normotension, have significantly lower values of heart rate, cardiac minute output, double product, and circulatory efficiency ratio, but a higher value of the peripheral vascular resistance. Students with sympathicotonia have statistically higher heart rate, cardiac minute output, and double product values.Conclusion. The assessment of hemodynamic parameters in healthy young people in relation to the threshold of salt sensitivity and the initial autonomic tone enables the risk factors for the development of hypertension to be assessed, prehypertension (high normal blood pressure) to be identified, and preventive programs aimed at reducing the number of diseases of the cardiovascular system to be developed.","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46820659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-22DOI: 10.25207/1608-6228-2023-30-3-34-43
N. Bykova, S. Sirak, A. Ovsyannikova, A. Arutyunov, A. Romanenko, E. Sirak, V. Grigoryan, Yu. V. Verevkina, Z. K. Shamanova
Background. The significant prevalence of chronic generalized periodontitis, the severity of its course, the increase in the number of complicated forms and short-term remissions cause a constant search for new methods and means of its treatment. When choosing the most effective methods of therapy, specialists mostly prefer a complex effect on the main pathogenetic links of the disease, while often losing sight of the body's own defenses, especially in terms of pharmacotherapeutic support and immunity strengthening. This study presents the results of a study of the clinical efficacy of the treatment of chronic generalized periodontitis by means of the developed therapy complex, including the use of immunomodulatory and osteotropic drugs.Objective — to study clinical efficacy of the developed complex immunomodulatory and osteotropic treatment for chronic generalized periodontitis.Methods. A prospective cohort study was conducted in 154 patients aged 20 to 75 with periodontitis of varying severity. Conventional examination of patients was carried out in specialized dental clinics DentoProma (Krasnodar) and Dentalife (Stavropol) based at the Dentistry Department, Stavropol State Medical University (Russia). The study period was 24 months. The patients were divided into a main group of 118 participants and a control group of 36 participants. The comprehensive treatment plan, prescribed to all patients, included proper oral hygiene education, individual and professional dental hygiene, topical anti-inflammatory agents, Vector therapy, open flap debridement, flap surgery, relevant splinting prosthetics (if necessary). The authors developed a comprehensive therapy, which included administration of the immunomodulatory agent Hepon (Immapharma Company, Russia), glucosamine hydrochloride and chondroitin sulfate sodium. All patients of the main and control groups were additionally ranked into subgroups depending on the severity of diagnosed periodontitis: slight (subgroup 1), moderate (subgroup 2) and severe (subgroup 3). The major focus of the study was to establish efficacy of the developed therapy which was defined by the degree of resolution of the inflammatory process and increase in the period of remission. Reflecting the presence and degree of inflammation, dental plaque index and oral hygiene status were considered to be the target indicators. Analysis and statistical processing of the obtained data were carried out using Microsoft Excel (Microsoft, USA).Results. The analysis of the data revealed that the immediate clinical results of the developed complex therapy both in the main group and in the control group were approximately identical. According to the follow-up data obtained one month after the treatment, additional prescription of complex osteotropic treatment to the patients with chronic generalized periodontitis contributed to rapid resolution of infection in the gingival tissues and provided stable treatment results.Conclusion. Introductio
{"title":"Index Evaluation of Clinical Efficacy of Immunomodulatory and Osteotropic Therapy for Chronic Generalized Periodontitis of Varying Severity: A Prospective Cohort Study","authors":"N. Bykova, S. Sirak, A. Ovsyannikova, A. Arutyunov, A. Romanenko, E. Sirak, V. Grigoryan, Yu. V. Verevkina, Z. K. Shamanova","doi":"10.25207/1608-6228-2023-30-3-34-43","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-3-34-43","url":null,"abstract":"Background. The significant prevalence of chronic generalized periodontitis, the severity of its course, the increase in the number of complicated forms and short-term remissions cause a constant search for new methods and means of its treatment. When choosing the most effective methods of therapy, specialists mostly prefer a complex effect on the main pathogenetic links of the disease, while often losing sight of the body's own defenses, especially in terms of pharmacotherapeutic support and immunity strengthening. This study presents the results of a study of the clinical efficacy of the treatment of chronic generalized periodontitis by means of the developed therapy complex, including the use of immunomodulatory and osteotropic drugs.Objective — to study clinical efficacy of the developed complex immunomodulatory and osteotropic treatment for chronic generalized periodontitis.Methods. A prospective cohort study was conducted in 154 patients aged 20 to 75 with periodontitis of varying severity. Conventional examination of patients was carried out in specialized dental clinics DentoProma (Krasnodar) and Dentalife (Stavropol) based at the Dentistry Department, Stavropol State Medical University (Russia). The study period was 24 months. The patients were divided into a main group of 118 participants and a control group of 36 participants. The comprehensive treatment plan, prescribed to all patients, included proper oral hygiene education, individual and professional dental hygiene, topical anti-inflammatory agents, Vector therapy, open flap debridement, flap surgery, relevant splinting prosthetics (if necessary). The authors developed a comprehensive therapy, which included administration of the immunomodulatory agent Hepon (Immapharma Company, Russia), glucosamine hydrochloride and chondroitin sulfate sodium. All patients of the main and control groups were additionally ranked into subgroups depending on the severity of diagnosed periodontitis: slight (subgroup 1), moderate (subgroup 2) and severe (subgroup 3). The major focus of the study was to establish efficacy of the developed therapy which was defined by the degree of resolution of the inflammatory process and increase in the period of remission. Reflecting the presence and degree of inflammation, dental plaque index and oral hygiene status were considered to be the target indicators. Analysis and statistical processing of the obtained data were carried out using Microsoft Excel (Microsoft, USA).Results. The analysis of the data revealed that the immediate clinical results of the developed complex therapy both in the main group and in the control group were approximately identical. According to the follow-up data obtained one month after the treatment, additional prescription of complex osteotropic treatment to the patients with chronic generalized periodontitis contributed to rapid resolution of infection in the gingival tissues and provided stable treatment results.Conclusion. Introductio","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42466278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-22DOI: 10.25207/1608-6228-2023-30-3-56-64
Yuri Yu. Byalovsky, I. Rakitina
Background. In various situations healthy people may experience breathlessness caused by high altitude, breath-holding, anxiety or panic driven by stressful events, and, very often by physical activity. However, variability in perception of dyspnea in healthy individuals is yet to be explored. The present study analyzes the variability of dyspnea perception in healthy people in the context of additional respiratory resistance.Objective — to assess the variability in perception of dyspnea in healthy individuals against a step-up increase in additional respiratory resistance, and to evaluate the relationship between dyspnea perception and physical activity levels.Methods. A cross-sectional observational exploratory study involved healthy individuals aged 19–25. The study was conducted at the Department of Pathophysiology, Ryazan State Medical University named after acad. I.P. Pavlov (Russia), in the period from November 2018 to June 2019. A total number of individuals under study comprised 42. Study participants were subjected to additional respiratory resistance, when dyspnea perception was estimated using a modified Borg scale. Then all participants were divided into three groups according to the tertiles in their perception: slight perception (Borg score < 2; n = 13), moderate perception (Borg score 2–5; n = 19) and high perception (Borg score > 5, n = 13). The study involved determination of body mass index, maximal airway pressure, pulmonary function, physical activity by means of IPAQ (International Physical Activity Questionnaire) and 6MWT (6 Minute Walking Test). Data analysis was performed using IBM SPSS Statistics 17.0 (USA).Results. The study included 42 healthy individuals. The level of dyspnea perception was determined as slight (low), moderate (medium) and high in 13, 19 and 10 participants, respectively. Perceived level of breathlessness did not significantly correlate with age, gender, body mass index, physical activity, maximum airway pressure or pulmonary function test results.Conclusion. Perceived dyspnea caused by a step-up increase in additional respiratory resistance varied significantly. The perception of dyspnea was determined as slight in 31% of participants, moderate in 45% and high in 24%. The authors did not reveal a correlation between dyspnea perception and physical activity level (via IPAQ or 6 Minute Walking Test).
{"title":"Variability in Perception of Dyspnea in the Context of Additional Respiratory Resistance: Cross-Sectional Observational Exploratory Study","authors":"Yuri Yu. Byalovsky, I. Rakitina","doi":"10.25207/1608-6228-2023-30-3-56-64","DOIUrl":"https://doi.org/10.25207/1608-6228-2023-30-3-56-64","url":null,"abstract":"Background. In various situations healthy people may experience breathlessness caused by high altitude, breath-holding, anxiety or panic driven by stressful events, and, very often by physical activity. However, variability in perception of dyspnea in healthy individuals is yet to be explored. The present study analyzes the variability of dyspnea perception in healthy people in the context of additional respiratory resistance.Objective — to assess the variability in perception of dyspnea in healthy individuals against a step-up increase in additional respiratory resistance, and to evaluate the relationship between dyspnea perception and physical activity levels.Methods. A cross-sectional observational exploratory study involved healthy individuals aged 19–25. The study was conducted at the Department of Pathophysiology, Ryazan State Medical University named after acad. I.P. Pavlov (Russia), in the period from November 2018 to June 2019. A total number of individuals under study comprised 42. Study participants were subjected to additional respiratory resistance, when dyspnea perception was estimated using a modified Borg scale. Then all participants were divided into three groups according to the tertiles in their perception: slight perception (Borg score < 2; n = 13), moderate perception (Borg score 2–5; n = 19) and high perception (Borg score > 5, n = 13). The study involved determination of body mass index, maximal airway pressure, pulmonary function, physical activity by means of IPAQ (International Physical Activity Questionnaire) and 6MWT (6 Minute Walking Test). Data analysis was performed using IBM SPSS Statistics 17.0 (USA).Results. The study included 42 healthy individuals. The level of dyspnea perception was determined as slight (low), moderate (medium) and high in 13, 19 and 10 participants, respectively. Perceived level of breathlessness did not significantly correlate with age, gender, body mass index, physical activity, maximum airway pressure or pulmonary function test results.Conclusion. Perceived dyspnea caused by a step-up increase in additional respiratory resistance varied significantly. The perception of dyspnea was determined as slight in 31% of participants, moderate in 45% and high in 24%. The authors did not reveal a correlation between dyspnea perception and physical activity level (via IPAQ or 6 Minute Walking Test).","PeriodicalId":33483,"journal":{"name":"Kubanskii nauchnyi meditsinskii vestnik","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41642727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：