Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.433
S. Kalay, T. Çandar
Background: The analysis of lipid profiles is a crucial step for cardiovascular risk evaluation, prevention, and therapeutic management. Small dense LDL (sdLDL) is one of the distinct subfractions of LDL and is established to have pro-atherogenic properties. Ischemia-modified albumin (IMA) is an early biomarker arising as a result of oxidative stress and ischemia. Objective: This study aimed to determine serum levels of sdLDL and IMA in patients with hyperlipidemia. Methods: Seventy-four patients with hyperlipidemia and 35 healthy controls were included. sdLDL was determined by the heparin-magnesium precipitation method. IMA was measured quantified manually with the colorimetric method. The patient group was divided into three groups: HyperTG (n=11), HyperLDL (n=38), and combined hyperlipidemia (n=25). Results: Median serum sdLDL and IMA levels were higher in patients with hyperlipidemia than healthy participants (both, p<0.001). Elevated sdLDL levels were observed in the HyperLDL group compared to the HyperTG group and the combined hyperlipidemia group (p<0.001). Cut-off values for the detection of patients with hyperlipidemia were >70 mg/dL for sdLDL and >0.7 AU for IMA, and both parameters showed considerably high levels of sensitivity and specificity. Multiple logistic regression analysis revealed that high sdLDL (p=0.042) and high IMA (p<0.001) were independently associated with hyperlipidemia after adjusting for age and sex. Conclusion: Serum sdLDL and IMA levels could be used as biomarkers for dyslipidemia-associated diseases. Further studies with larger sample size are needed to validate the impact of sdLDL on the pathogenesis of atherogenesis, and its value in the diagnosis and prognosis hyperlipidemia. Keywords: Small dense LDL, Lipoprotein, Ischemia modified albumin, IMA, Atherosclerosis
{"title":"The Role of Small Dense LDL Cholesterol and Ischemia Modified Albumin in Patients with Hyperlipidemia","authors":"S. Kalay, T. Çandar","doi":"10.46347/jmsh.v9i1.22.433","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.433","url":null,"abstract":"Background: The analysis of lipid profiles is a crucial step for cardiovascular risk evaluation, prevention, and therapeutic management. Small dense LDL (sdLDL) is one of the distinct subfractions of LDL and is established to have pro-atherogenic properties. Ischemia-modified albumin (IMA) is an early biomarker arising as a result of oxidative stress and ischemia. Objective: This study aimed to determine serum levels of sdLDL and IMA in patients with hyperlipidemia. Methods: Seventy-four patients with hyperlipidemia and 35 healthy controls were included. sdLDL was determined by the heparin-magnesium precipitation method. IMA was measured quantified manually with the colorimetric method. The patient group was divided into three groups: HyperTG (n=11), HyperLDL (n=38), and combined hyperlipidemia (n=25). Results: Median serum sdLDL and IMA levels were higher in patients with hyperlipidemia than healthy participants (both, p<0.001). Elevated sdLDL levels were observed in the HyperLDL group compared to the HyperTG group and the combined hyperlipidemia group (p<0.001). Cut-off values for the detection of patients with hyperlipidemia were >70 mg/dL for sdLDL and >0.7 AU for IMA, and both parameters showed considerably high levels of sensitivity and specificity. Multiple logistic regression analysis revealed that high sdLDL (p=0.042) and high IMA (p<0.001) were independently associated with hyperlipidemia after adjusting for age and sex. Conclusion: Serum sdLDL and IMA levels could be used as biomarkers for dyslipidemia-associated diseases. Further studies with larger sample size are needed to validate the impact of sdLDL on the pathogenesis of atherogenesis, and its value in the diagnosis and prognosis hyperlipidemia. Keywords: Small dense LDL, Lipoprotein, Ischemia modified albumin, IMA, Atherosclerosis","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47918542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.409
Trisha Banik, Rajarshi Bhattacharyya, N. Basu, Sabya Sachi Maje
Background: Carcinoma of lung has now become increasingly frequent during the last 60 years; this increase is seen in males and especially in the females. Cytological evaluation from respiratory tract is the initial investigation along with radiological investigations in patients suspected to have pulmonary diseases. The various cytological samples included transbronchial needle aspiration, guided fine needle aspiration cytology (FNAC) smears and pleural fluid. Present study was undertaken to study the spectrum of lesions diagnosed by cytomorphological analysis of various cytological samples and correlation of the histopathology, cytology and radiology of lung lesions. Materials and Methods: Centrifuged and direct smears from received samples were stained with MGG and PAP stain. Cytohistological correlation was done when biopsy was available with radiological correlation & comparison of topographic display. Results: Present study was carried out during the period of December 2018 to November 2019. During this period, of total 52 cases, 36 (69.2%) were males and 16 (30.8%) were females. Their age ranged from 26 years to 73 years, most patients (53.8) belonged to the age group of 56 – 65 years. The literacy status of the patients was assessed. 2 out of 52 (3.8%) patients were illiterate, 8 out of 52 (15.4%) patients were educated above H.S. level. Adenocarcinoma was seen to be the most prevalent 29 (55.7%) followed by squamous cell carcinoma 12 (23.0%) among the cases studied. Smoking was seen to be the most common addiction i.e. 34 out of 52 cases (65.4%). Among non-smokers 66.7% presented with adenocarcinoma and 16.6% cases with squamous cell carcinoma. The topography of the neoplasms within the lungs was assessed radiologically. On chest X ray (82.6%) lung lesions were identified; (48%) of patients were found to have pleural effusion. By using CT SCAN, all masses were located definitely. Conclusion: A good correlation between cytology and histopathology is revealed in our study. Guided FNAC helps in early detection and diagnosis of lung lesions and facilitates appropriate management of patients. Keywords: Lung, Carcinoma, Detection, Diagnosis, Fine needle aspiration, Cytology, Histopathology, Radiology, Correlation
{"title":"Role of FNAC in Early Detection and Diagnosis of Lung Lesions with Histo-radiological Correlation and Clinical Insights in a Tertiary Care Centre","authors":"Trisha Banik, Rajarshi Bhattacharyya, N. Basu, Sabya Sachi Maje","doi":"10.46347/jmsh.v9i1.22.409","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.409","url":null,"abstract":"Background: Carcinoma of lung has now become increasingly frequent during the last 60 years; this increase is seen in males and especially in the females. Cytological evaluation from respiratory tract is the initial investigation along with radiological investigations in patients suspected to have pulmonary diseases. The various cytological samples included transbronchial needle aspiration, guided fine needle aspiration cytology (FNAC) smears and pleural fluid. Present study was undertaken to study the spectrum of lesions diagnosed by cytomorphological analysis of various cytological samples and correlation of the histopathology, cytology and radiology of lung lesions. Materials and Methods: Centrifuged and direct smears from received samples were stained with MGG and PAP stain. Cytohistological correlation was done when biopsy was available with radiological correlation & comparison of topographic display. Results: Present study was carried out during the period of December 2018 to November 2019. During this period, of total 52 cases, 36 (69.2%) were males and 16 (30.8%) were females. Their age ranged from 26 years to 73 years, most patients (53.8) belonged to the age group of 56 – 65 years. The literacy status of the patients was assessed. 2 out of 52 (3.8%) patients were illiterate, 8 out of 52 (15.4%) patients were educated above H.S. level. Adenocarcinoma was seen to be the most prevalent 29 (55.7%) followed by squamous cell carcinoma 12 (23.0%) among the cases studied. Smoking was seen to be the most common addiction i.e. 34 out of 52 cases (65.4%). Among non-smokers 66.7% presented with adenocarcinoma and 16.6% cases with squamous cell carcinoma. The topography of the neoplasms within the lungs was assessed radiologically. On chest X ray (82.6%) lung lesions were identified; (48%) of patients were found to have pleural effusion. By using CT SCAN, all masses were located definitely. Conclusion: A good correlation between cytology and histopathology is revealed in our study. Guided FNAC helps in early detection and diagnosis of lung lesions and facilitates appropriate management of patients. Keywords: Lung, Carcinoma, Detection, Diagnosis, Fine needle aspiration, Cytology, Histopathology, Radiology, Correlation","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42024636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.292
M. R., R. Udgiri, Ashalatha Mallapur, Shailaja S Patil
Background: Nutrient intake is important to the well-being of pregnant women and the fetus. Most of the previous studies points nutrition status based on energy and protein intake. However there are few studies indicate the use of dietary diversity as a marker of assessing the nutrition status. Healthy diets include the most diverse foods, and balance in eating food provides maternal and fetal health and reduces the prevalence of Low birthweight. Objectives: The objectives of the present study are to find out the association between Dietary diversity score with the nutrition status of the Pregnant Women (Gestational weight gain and nutritional anaemia.) And to find out the effects of gestational weight gain and nutritional anemia on the birth weight of the baby. Methods: An Institutional ethical clearance was obtained and the present Hospital based study was carried out in the OBG department of tertiary care centre of North Karnataka between December 2019 to February 2020. Sample size was estimated to be 120. Results: In the present study, a total of 120 women participated in the study. The Mean age of the study participants was 25.2±3.4, and the study found mean DDS was 7.04±1.58, with the scores ranging from 3 to 12. Association between the Dietary diversity score (DDS) and birthweight of the baby was found to be statistically significant (p=0.03) There is a statistically significant difference in DDS mean score between anaemic and normal pregnant women (p=0.007). There was a statistically significant positive correlation between Gestational weight gain and birth weight of the baby (p=0.03). There were positive correlation between the DDS and the Birthweight and Gestational weight gain, though it was statistically non-significant. Conclusion: Nutrition education for pregnant women should include the facts about the different food groups, it advantages will help to include diverse food items in their diet. Keywords: Dietary diversity score, Gestational weight gain, Birth weight
{"title":"Effect of Dietary Diversity on the Nutritional Status in Pregnant Women and in Turn its Effect on Birth Weight of the Baby","authors":"M. R., R. Udgiri, Ashalatha Mallapur, Shailaja S Patil","doi":"10.46347/jmsh.v9i1.22.292","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.292","url":null,"abstract":"Background: Nutrient intake is important to the well-being of pregnant women and the fetus. Most of the previous studies points nutrition status based on energy and protein intake. However there are few studies indicate the use of dietary diversity as a marker of assessing the nutrition status. Healthy diets include the most diverse foods, and balance in eating food provides maternal and fetal health and reduces the prevalence of Low birthweight. Objectives: The objectives of the present study are to find out the association between Dietary diversity score with the nutrition status of the Pregnant Women (Gestational weight gain and nutritional anaemia.) And to find out the effects of gestational weight gain and nutritional anemia on the birth weight of the baby. Methods: An Institutional ethical clearance was obtained and the present Hospital based study was carried out in the OBG department of tertiary care centre of North Karnataka between December 2019 to February 2020. Sample size was estimated to be 120. Results: In the present study, a total of 120 women participated in the study. The Mean age of the study participants was 25.2±3.4, and the study found mean DDS was 7.04±1.58, with the scores ranging from 3 to 12. Association between the Dietary diversity score (DDS) and birthweight of the baby was found to be statistically significant (p=0.03) There is a statistically significant difference in DDS mean score between anaemic and normal pregnant women (p=0.007). There was a statistically significant positive correlation between Gestational weight gain and birth weight of the baby (p=0.03). There were positive correlation between the DDS and the Birthweight and Gestational weight gain, though it was statistically non-significant. Conclusion: Nutrition education for pregnant women should include the facts about the different food groups, it advantages will help to include diverse food items in their diet. Keywords: Dietary diversity score, Gestational weight gain, Birth weight","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48060062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.343
Aparna Mohan, Michell Gulabani, A. Tyagi, Jubin Jakhar, Mahendra Kumar
Background: Percutaneous nephrolithotomy (PCNL) surgery may be associated with postoperative Acute Kidney Injury (AKI). Commonest intraoperative risk factors for postoperative AKI include hypotension and hypoperfusion. Intravenous fluids are administered during surgery to optimize intravascular status and thus prevent hypotension. Conventionally, intravenous fluids are administered during surgery using pre-calculated volumes based on maintenance needs. Alternatively, goal-directed fluid therapy using Stroke Volume Variation (SVV) can be used to decide the volume of intravenous fluids. We compared early postoperative AKI following intraoperative use of conventional (group C, n=15) versus SVV directed fluid therapy (group S, n = 17) in patients undergoing PCNL surgery. Methods: This double-blinded pilot study involved 32 adult patients, randomised to two groups according to type of intraoperative fluid therapy (group C or group S). Postoperative AKI was diagnosed as per KDIGO guidelines. Results: Incidence of early postoperative AKI was clinically higher for group S, though statistically similar, as compared to group C (47.1% versus 26.7%) (P = 0.234). Postoperative increase in eGFR, and 24-hour urine output were clinically greater for group S (P > 0.05). Volume of intraoperative fluids infused was significantly lesser for group S (P = 0.000). The incidence of hypotension and requirement of vasopressor to maintain blood pressure was clinically lesser, though statistically similar for group S as compared to group C (P = 0.659). Conclusions: There appears to be a clinical trend of greater incidence of AKI with use of SVV guided therapy despite better intraoperative hemodynamic stability and greater improvement in postoperative urine output and eGFR in the first postoperative day. Keywords: Percutaneous nephrolithotomy, Acute kidney injury, Fluid therapy, General anesthesia, Blood pressure
{"title":"Stroke Volume Variation Directed Versus Conventional Fluid Therapy for Postoperative Acute Kidney Injury after Percutaneous Nephrolithotomy - A Randomized Pilot Study","authors":"Aparna Mohan, Michell Gulabani, A. Tyagi, Jubin Jakhar, Mahendra Kumar","doi":"10.46347/jmsh.v9i1.22.343","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.343","url":null,"abstract":"Background: Percutaneous nephrolithotomy (PCNL) surgery may be associated with postoperative Acute Kidney Injury (AKI). Commonest intraoperative risk factors for postoperative AKI include hypotension and hypoperfusion. Intravenous fluids are administered during surgery to optimize intravascular status and thus prevent hypotension. Conventionally, intravenous fluids are administered during surgery using pre-calculated volumes based on maintenance needs. Alternatively, goal-directed fluid therapy using Stroke Volume Variation (SVV) can be used to decide the volume of intravenous fluids. We compared early postoperative AKI following intraoperative use of conventional (group C, n=15) versus SVV directed fluid therapy (group S, n = 17) in patients undergoing PCNL surgery. Methods: This double-blinded pilot study involved 32 adult patients, randomised to two groups according to type of intraoperative fluid therapy (group C or group S). Postoperative AKI was diagnosed as per KDIGO guidelines. Results: Incidence of early postoperative AKI was clinically higher for group S, though statistically similar, as compared to group C (47.1% versus 26.7%) (P = 0.234). Postoperative increase in eGFR, and 24-hour urine output were clinically greater for group S (P > 0.05). Volume of intraoperative fluids infused was significantly lesser for group S (P = 0.000). The incidence of hypotension and requirement of vasopressor to maintain blood pressure was clinically lesser, though statistically similar for group S as compared to group C (P = 0.659). Conclusions: There appears to be a clinical trend of greater incidence of AKI with use of SVV guided therapy despite better intraoperative hemodynamic stability and greater improvement in postoperative urine output and eGFR in the first postoperative day. Keywords: Percutaneous nephrolithotomy, Acute kidney injury, Fluid therapy, General anesthesia, Blood pressure","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47144417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.21.22
O. R. Krishna, Narahari Bapanpally, S. Fatima, G. Padmaja
Background: Sickle cells are easily identified on the peripheral smear however quantification of sickle cells is seldom done. This study attempts to understand the importance of the sickling index in the reporting of peripheral smear in patients with SCD. Objectives: This study aims to standardize the methodology of quantification of sickle cells on the peripheral smear in paediatric SCD cases and study its relation to the patient characteristics like age and sex, SCD genotype, and treatment. Materials and Methods: A prospective study of 6 months duration was conducted at a tertiary paediatric referral hospital for 6 months. 30 known cases of SCD were admitted during this period. Routinely studied peripheral smears were used in the study. 30 normal smears of age-matched patients were also used for comparative purpose. The sickling index was calculated in both patient and age matched smears. The sickling index was compared in both the groups and also the index in the known SCD cases was studied in relation to the patient's age, SCD genotype, and treatment with blood transfusions or hydroxyurea. Statistical analysis: Descriptive statistics were used in the study Results & Conclusion: Hb SS was the commonest genotype seen in 69% of the cases. Higher sickling index was noted in older children, SS genotype and those on treatment with blood transfusions or Hydroxyurea. Sickling index is an interesting prospect which may provide helpful information regarding cases with increasing hemolysis and vasocclusive crises and also help in follow up of patients on treatment. Keywords: Paediatric, Disease severity, Sickling index
{"title":"Quantification of Sickle Cells in the Peripheral Smear as a Marker of Disease Severity in Sickle Cell Disease in Paediatric Patients","authors":"O. R. Krishna, Narahari Bapanpally, S. Fatima, G. Padmaja","doi":"10.46347/jmsh.v9i1.21.22","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.21.22","url":null,"abstract":"Background: Sickle cells are easily identified on the peripheral smear however quantification of sickle cells is seldom done. This study attempts to understand the importance of the sickling index in the reporting of peripheral smear in patients with SCD. Objectives: This study aims to standardize the methodology of quantification of sickle cells on the peripheral smear in paediatric SCD cases and study its relation to the patient characteristics like age and sex, SCD genotype, and treatment. Materials and Methods: A prospective study of 6 months duration was conducted at a tertiary paediatric referral hospital for 6 months. 30 known cases of SCD were admitted during this period. Routinely studied peripheral smears were used in the study. 30 normal smears of age-matched patients were also used for comparative purpose. The sickling index was calculated in both patient and age matched smears. The sickling index was compared in both the groups and also the index in the known SCD cases was studied in relation to the patient's age, SCD genotype, and treatment with blood transfusions or hydroxyurea. Statistical analysis: Descriptive statistics were used in the study Results & Conclusion: Hb SS was the commonest genotype seen in 69% of the cases. Higher sickling index was noted in older children, SS genotype and those on treatment with blood transfusions or Hydroxyurea. Sickling index is an interesting prospect which may provide helpful information regarding cases with increasing hemolysis and vasocclusive crises and also help in follow up of patients on treatment. Keywords: Paediatric, Disease severity, Sickling index","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48894456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.365
G. Neethu, T. Mounika, P. Rashmi, V. Kulkarni
Objectives: To compare the traditional teaching with algorithm or flowchart-based teaching method in cytology and to assess the performance of newly joined residents in cytopathology after training them with algorithm-based approach. Materials & Methods: The study included 20 newly joined residents who were divided into two groups I.e., group A and group B and was conducted in two different sets. In set 1, group A residents were trained with the algorithmic approach and group B residents by theoretical method for 10 different cytological cases of thyroid and breast. In set 2, group B residents were taught the algorithmic approach and group A residents by theoretical method for 10 different cytological cases of salivary gland and lymph node. The performance of the residents in both the sets was assessed and pre-test and post-test scores were given based on their ability to diagnose the lesions before and after the training. The feedback on the utility of algorithmic approach in cytopathology was received from the participated residents after the study. Results: The performance of the residents was compared using Mann Whitney U test of post-test scores and was found that in set 1, group A residents’ performance was greater than that of group B residents. Similarly for the set 2, the performance of group B residents was greater than group A residents. The performance of group A residents in set 2 was found to be better than their performance in set 1. Conclusion: The algorithm or flowchart-based teaching is a unique teaching method which enhances case solving skills and effective reasoning in the residents. Keywords: Algorithm based approach, Cytopathology, FNAC, Pathology resident training
{"title":"Algorithmic Approach in Cytopathology : A Mode of Training the New Residents","authors":"G. Neethu, T. Mounika, P. Rashmi, V. Kulkarni","doi":"10.46347/jmsh.v9i1.22.365","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.365","url":null,"abstract":"Objectives: To compare the traditional teaching with algorithm or flowchart-based teaching method in cytology and to assess the performance of newly joined residents in cytopathology after training them with algorithm-based approach. Materials & Methods: The study included 20 newly joined residents who were divided into two groups I.e., group A and group B and was conducted in two different sets. In set 1, group A residents were trained with the algorithmic approach and group B residents by theoretical method for 10 different cytological cases of thyroid and breast. In set 2, group B residents were taught the algorithmic approach and group A residents by theoretical method for 10 different cytological cases of salivary gland and lymph node. The performance of the residents in both the sets was assessed and pre-test and post-test scores were given based on their ability to diagnose the lesions before and after the training. The feedback on the utility of algorithmic approach in cytopathology was received from the participated residents after the study. Results: The performance of the residents was compared using Mann Whitney U test of post-test scores and was found that in set 1, group A residents’ performance was greater than that of group B residents. Similarly for the set 2, the performance of group B residents was greater than group A residents. The performance of group A residents in set 2 was found to be better than their performance in set 1. Conclusion: The algorithm or flowchart-based teaching is a unique teaching method which enhances case solving skills and effective reasoning in the residents. Keywords: Algorithm based approach, Cytopathology, FNAC, Pathology resident training","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43353114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.374
Teleflo Boopathy, S. Kanimozhi, V. Ramya, P. L. Piriya
Diabetic mastopathy is an uncommon fibrous tissue lesion of the breast which is usually seen in patients with longstanding type 1 diabetes mellitus. We report a case of diabetic mastopathy in an insulin dependent type 2 diabetes mellitus patient. 47-year-old postmenopausal woman, presented with two lumps, one firm mobile mass and another, a firm-hard mass in the upper inner quadrant of the left breast. Mammography and ultrasonography came out to be BIRADS III lesion. Fine-needle aspiration cytology [FNAC] was performed showing features of fibroadenoma with fibrocystic change. Histopathological examination and Immunohistochemistry studies revealed it to be fibroadenoma along with lymphocytic mastopathy. Keywords: Fibroadenoma, Lymphocytic mastitis, Mimicker, Diabetes
{"title":"Lymphocytic Mastitis with Fibroadenoma – A Case Report","authors":"Teleflo Boopathy, S. Kanimozhi, V. Ramya, P. L. Piriya","doi":"10.46347/jmsh.v9i1.22.374","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.374","url":null,"abstract":"Diabetic mastopathy is an uncommon fibrous tissue lesion of the breast which is usually seen in patients with longstanding type 1 diabetes mellitus. We report a case of diabetic mastopathy in an insulin dependent type 2 diabetes mellitus patient. 47-year-old postmenopausal woman, presented with two lumps, one firm mobile mass and another, a firm-hard mass in the upper inner quadrant of the left breast. Mammography and ultrasonography came out to be BIRADS III lesion. Fine-needle aspiration cytology [FNAC] was performed showing features of fibroadenoma with fibrocystic change. Histopathological examination and Immunohistochemistry studies revealed it to be fibroadenoma along with lymphocytic mastopathy. Keywords: Fibroadenoma, Lymphocytic mastitis, Mimicker, Diabetes","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43419874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.492
B. Soumya, L. Sharma, V. Kulkarni, C. Preethi
The spectrum of lipomatous lesions ranges from benign to highly malignant disease. Differentiation between these mesenchymal lesions is important for pathologist as well as clinician to indicate prognosis and choose the most appropriate treatment. Hemosiderotic firohistiocytic lipomatous tumor (HFLT) is a rare subtype of lipomatous tumor. The diagnosis is usually based on clinical, histological, and immunohistochemical (IHC) information. We reported a case of 56 years old man with a painful mass in the dorsal aspect of the thigh showing an unusal clinical presentation but a characteristic histological and IHC features. In this article we have retrospectively reviewed the 67 cases of HFLT reported in literature so far along with one case reported at our institution. The review focuses on clinicopathological and histomorphological characteristics of HFLT and the related entities. The hallmark of HFLT and its related lesions is complex admixture of mature adipose tissue, spindle tumor cells with striking deposition of hemosiderin pigment. Even though HFLT shows marked predeliction for the distal extremeties especially the foot/ ankle with a female preponderance, they can occur at uncommon site such as thigh and also in males as seen in our case. Keywords: Pleomorphic hyalinizing angiectatic tumor, Hemosiderotic fibrolipomatous tumor, Myxoinflammatory Fibroblastic Sarcoma, Hemosiderin, Lipoma
{"title":"Report of an Unusual Case of Hemosiderotic Fibrohistiocytic Lipomatous Tumor with Systematic Review of Clinicopathological Characteristics and Differential Diagnosis","authors":"B. Soumya, L. Sharma, V. Kulkarni, C. Preethi","doi":"10.46347/jmsh.v9i1.22.492","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.492","url":null,"abstract":"The spectrum of lipomatous lesions ranges from benign to highly malignant disease. Differentiation between these mesenchymal lesions is important for pathologist as well as clinician to indicate prognosis and choose the most appropriate treatment. Hemosiderotic firohistiocytic lipomatous tumor (HFLT) is a rare subtype of lipomatous tumor. The diagnosis is usually based on clinical, histological, and immunohistochemical (IHC) information. We reported a case of 56 years old man with a painful mass in the dorsal aspect of the thigh showing an unusal clinical presentation but a characteristic histological and IHC features. In this article we have retrospectively reviewed the 67 cases of HFLT reported in literature so far along with one case reported at our institution. The review focuses on clinicopathological and histomorphological characteristics of HFLT and the related entities. The hallmark of HFLT and its related lesions is complex admixture of mature adipose tissue, spindle tumor cells with striking deposition of hemosiderin pigment. Even though HFLT shows marked predeliction for the distal extremeties especially the foot/ ankle with a female preponderance, they can occur at uncommon site such as thigh and also in males as seen in our case. Keywords: Pleomorphic hyalinizing angiectatic tumor, Hemosiderotic fibrolipomatous tumor, Myxoinflammatory Fibroblastic Sarcoma, Hemosiderin, Lipoma","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47406376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.21.253
Salman Mohammad Tariq, K. Khan, M. M. Sadiq, S. Pooja, Sindhu Suyog, S. K. Devendra
Objective: Black cumin (Nigella sativa L.) seeds and its crude extract or essential oils have been widely used traditionally for nutritional and medicinal applications in Asian countries. Its effects on diabetics with high fat diet consumption have not been adequately studied. This study was undertaken to study its effects on body weight, abdominal girth, lipid profile and plasma glucose levels in diabetic high fat diet fed rats. Materials and Methods : Streptozotocin induced male Wistar rats were fed high fat diet [5130 kcal] for 4 weeks after which they were given vehicle, Nigella sativa ethanolic extract (300mg/kg), Nigella sativa ethanolic extract (600 mg) or metformin (100 mg). Lipid profile, blood glucose, body weight & abdominal girth were measured. Results: Nigella sativa ethanolic extract (600 mg) caused significant reduction in blood glucose, total cholesterol, triglycerides, VLDL and non HDL cholesterol comparable to metformin. Conclusion : Nigella sativa shows anti-hyperglycemic effects and improvement in lipid profile in diabetic high fat diet fed rats which is comparable to metformin. Further studies are required to advocate its use in patients with diabetes and dyslipidemias. Keywords: Nigella sativa, diabetes mellitus, antihyperlipidemic, antihyperglycemic, high fat
{"title":"Nigella Sativa's Effect on Biochemical as well as Anthropometric Parameters in Diabetic Rats on High Fat Diet","authors":"Salman Mohammad Tariq, K. Khan, M. M. Sadiq, S. Pooja, Sindhu Suyog, S. K. Devendra","doi":"10.46347/jmsh.v9i1.21.253","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.21.253","url":null,"abstract":"Objective: Black cumin (Nigella sativa L.) seeds and its crude extract or essential oils have been widely used traditionally for nutritional and medicinal applications in Asian countries. Its effects on diabetics with high fat diet consumption have not been adequately studied. This study was undertaken to study its effects on body weight, abdominal girth, lipid profile and plasma glucose levels in diabetic high fat diet fed rats. Materials and Methods : Streptozotocin induced male Wistar rats were fed high fat diet [5130 kcal] for 4 weeks after which they were given vehicle, Nigella sativa ethanolic extract (300mg/kg), Nigella sativa ethanolic extract (600 mg) or metformin (100 mg). Lipid profile, blood glucose, body weight & abdominal girth were measured. Results: Nigella sativa ethanolic extract (600 mg) caused significant reduction in blood glucose, total cholesterol, triglycerides, VLDL and non HDL cholesterol comparable to metformin. Conclusion : Nigella sativa shows anti-hyperglycemic effects and improvement in lipid profile in diabetic high fat diet fed rats which is comparable to metformin. Further studies are required to advocate its use in patients with diabetes and dyslipidemias. Keywords: Nigella sativa, diabetes mellitus, antihyperlipidemic, antihyperglycemic, high fat","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45118477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.46347/jmsh.v9i1.22.512
Benjamin Jelley, T. Hughes, Phil Jones
Background: The All Wales Stroke Meeting (AWSM) is a multidisciplinary stroke meeting. Stroke clinicians can present cases to review the neuroradiology and discuss the clinical story to further clinical care, seek consensus views on the management in specific rare or complex cases or provide an educational opportunity for the group centred around a rare case or specific feature of the case. Methods: The meeting was created to pool the knowledge of clinicians working across Wales to benefit patient care throughout the country. Here we describe the development, structure and personnel involved in the meeting. There is a focus on the technological requirements of the meeting and how utilising newly introduced IT solutions further improved the meeting’s accessibility. Results: There is a positive economic and environmental impact of delivering multidisciplinary meetings through videoconference technology. The AWSM is estimated to annually save 97.16 days of clinician time and £13,087.18 in travel expenses. We estimate a reduction of carbon footprint of 15,792.38–19,722.44 kg CO2. Conclusion: The AWSM has been an invaluable component of stroke healthcare in Wales since 2009. We think this is an example of where collaborative working and innovative use of technologies can benefit clinicians, patients, NHS services and the environment. Keywords: Stroke, Stroke evaluation, Video conference, Neuroradiology, Continued professional development, Education, Multidisciplinary meeting
{"title":"The Evolution and Environmental Benefits of the All Wales Stroke Meeting (AWSM), a Video Conference Multidisciplinary Meeting for Stroke Physicians","authors":"Benjamin Jelley, T. Hughes, Phil Jones","doi":"10.46347/jmsh.v9i1.22.512","DOIUrl":"https://doi.org/10.46347/jmsh.v9i1.22.512","url":null,"abstract":"Background: The All Wales Stroke Meeting (AWSM) is a multidisciplinary stroke meeting. Stroke clinicians can present cases to review the neuroradiology and discuss the clinical story to further clinical care, seek consensus views on the management in specific rare or complex cases or provide an educational opportunity for the group centred around a rare case or specific feature of the case. Methods: The meeting was created to pool the knowledge of clinicians working across Wales to benefit patient care throughout the country. Here we describe the development, structure and personnel involved in the meeting. There is a focus on the technological requirements of the meeting and how utilising newly introduced IT solutions further improved the meeting’s accessibility. Results: There is a positive economic and environmental impact of delivering multidisciplinary meetings through videoconference technology. The AWSM is estimated to annually save 97.16 days of clinician time and £13,087.18 in travel expenses. We estimate a reduction of carbon footprint of 15,792.38–19,722.44 kg CO2. Conclusion: The AWSM has been an invaluable component of stroke healthcare in Wales since 2009. We think this is an example of where collaborative working and innovative use of technologies can benefit clinicians, patients, NHS services and the environment. Keywords: Stroke, Stroke evaluation, Video conference, Neuroradiology, Continued professional development, Education, Multidisciplinary meeting","PeriodicalId":33653,"journal":{"name":"Journal of Medical Sciences and Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46151588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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