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Chronic subdural hematoma: Epidemiological analysis and factors associated with hematoma size – A single center experience 慢性硬膜下血肿:流行病学分析及与血肿大小相关的因素 - 单中心经验
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2023.12.005

Objective

This study aims to analyze the profile of patients with chronic subdural hematoma (cSDH) and to verify the factors associated with hematoma size.

Methods

We conducted a single-center, retrospective and observational case series of consecutive patients who underwent surgical treatment for cSDH at the Hospital de Clínicas de Passo Fundo, between 2018 and 2022. Data were extracted from the patients’ history records and imaging exams available. Patients’ characteristics were grouped and described through their respective prevalence. The relationship between patients’ characteristics and outcome (discharge or death) was analyzed using Fisher's exact test. Hematoma size was described in millimeters using means, and the relationship between hematoma size, patient age and hematoma side was tested using Student's t test.

Results

A total of 95 individuals were included in the study. Of these, 66.3 % were male and 7.4 % died. The mean age was 72 years. The most common symptoms and history findings were history of trauma (69.9 %), motor deficit (68.4 %) and cognitive deficit (26.3 %). The average hematoma size was similar on both sides, and showed an increasing trend with aging. The size of cSDH was also greater in those who presented motor deficits.

Conclusion

Surgically treated patients with cSDH had high rates of cognitive deficit, motor deficit and history of trauma. In addition, mortality rate was considered low and the size of hematoma was associated with age and motor deficits.

本研究旨在分析慢性硬膜下血肿(cSDH)患者的概况,并验证与血肿大小相关的因素。方法我们对2018年至2022年期间在帕索芬多(Passo Fundo)临床医院接受手术治疗的慢性硬膜下血肿连续患者进行了单中心、回顾性和观察性病例系列研究。数据提取自患者的病史记录和现有的影像学检查。对患者的特征进行了分组,并通过其各自的患病率进行了描述。患者特征与结果(出院或死亡)之间的关系采用费雪精确检验进行分析。血肿大小以毫米为单位,采用均值进行描述,血肿大小、患者年龄和血肿侧之间的关系采用学生 t 检验。其中 66.3% 为男性,7.4% 死亡。平均年龄为 72 岁。最常见的症状和病史结果是外伤史(69.9%)、运动障碍(68.4%)和认知障碍(26.3%)。两侧血肿的平均大小相似,并随着年龄的增长呈上升趋势。结论接受手术治疗的 cSDH 患者出现认知障碍、运动障碍和外伤史的比例较高。此外,死亡率较低,血肿大小与年龄和运动障碍有关。
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引用次数: 0
Delayed hematoma growth in a patient with thrombocytopenia 血小板减少症患者血肿延迟生长
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.01.002

Background

Hematoma growth rarely occurs after 24 h in patients with intracerebral hemorrhage (ICH). Here we report a case with delayed hematoma growth caused by thrombocytopenia.

Case presentation

A 68-year-old leukemia patient presented with sudden left-sided weakness. Initial computed tomography scans revealed a small basal ganglia hemorrhage without early expansion. However, three days later, there was a significant hematoma expansion coupled with thrombocytopenia. The patient's condition remained stable after treatment. Our case suggests that hematoma expansion may occur even 3 days after symptom onset in patients with ICH.

Conclusion

This underscores the significance of promptly recognizing and closely monitoring delayed hematoma growth in cases of ICH associated with leukemia to facilitate timely intervention.

背景脑出血(ICH)患者血肿生长很少在 24 小时后发生。我们在此报告了一例因血小板减少而导致血肿延迟生长的病例。病例介绍 一位 68 岁的白血病患者突然出现左侧肢体无力。最初的计算机断层扫描显示基底节小出血,但没有早期扩大。然而,三天后,血肿明显扩大并伴有血小板减少。治疗后,患者病情保持稳定。我们的病例表明,ICH 患者即使在症状出现 3 天后也可能出现血肿扩大。结论这强调了在白血病相关 ICH 病例中及时识别和密切监测延迟血肿生长以促进及时干预的重要性。
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引用次数: 0
The use of bioinformatic analysis to study intracerebral hemorrhage 利用生物信息分析研究脑出血
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.05.002

The integration of bioinformatics analysis into intracerebral hemorrhage (ICH)research represents a paradigm shift in our approach to understanding, diagnosing, and treating this complex neurological disorder. By leveraging the power of bioinformatics, the scientific community is poised to make significant strides in combating this devastating condition, ultimately improving patient outcomes and quality of life. This study provides a comprehensive overview of the application of bioinformatics tools and techniques in elucidating the genetic, molecular, and environmental underpinnings of ICH. Through a detailed examination of genomic sequencing, transcriptomics, proteomics, and machine learning, we explore how these bioinformatics approaches have contributed to identifying genetic variants, understanding molecular pathways, and discovering biomarkers related to ICH. Challenges such as data complexity, integration of multi-omics data, and the translation of bioinformatics findings into clinical practice are discussed, alongside ethical considerations surrounding data privacy and patient consent. This study underscores the critical role of bioinformatics in advancing our understanding of ICH, offering insights into its pathophysiology, and paving the way for personalized medicine and targeted therapeutic interventions.

将生物信息学分析融入脑出血(ICH)研究,代表着我们在理解、诊断和治疗这种复杂神经系统疾病的方法上发生了范式转变。通过利用生物信息学的力量,科学界有望在抗击这一毁灭性疾病方面取得重大进展,最终改善患者的预后和生活质量。本研究全面概述了生物信息学工具和技术在阐明 ICH 遗传、分子和环境基础方面的应用。通过对基因组测序、转录组学、蛋白质组学和机器学习的详细研究,我们探讨了这些生物信息学方法如何有助于识别基因变异、了解分子通路以及发现与 ICH 相关的生物标志物。我们还讨论了数据复杂性、多组学数据整合、将生物信息学发现转化为临床实践等挑战,以及围绕数据隐私和患者同意的伦理考虑。这项研究强调了生物信息学在促进我们对 ICH 的了解、提供对其病理生理学的见解以及为个性化医疗和靶向治疗干预铺平道路方面的关键作用。
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引用次数: 0
Anterior cranial fossa dural arteriovenous fistula presenting with left basal ganglia hemorrhage: A case report 前颅窝硬脑膜动静脉瘘伴有左侧基底节出血:病例报告
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2023.11.005

Background

Anterior cranial fossa dural arteriovenous fistulas (ACF-dAVFs) usually drain into the superior sagittal sinus (SSS) via the cortical veins. More rarely, the ACF-dAVF drains posteriorly into the olfactory vein, which points deeply into the basal vein of Rosenthal.

Case presentation

Here, we report a previously unreported case of ACF-dAVF with basal ganglia hemorrhage as the clinical symptom, in which the fistula drained posteriorly into the straight sinus via the olfactory vein, the basal vein of Rosenthal and the Galen vein. Obstruction of the draining vein leads to the formation of a venous bulb in the mid-basal vein of Rosenthal, which eventually causes basal ganglia hemorrhage.

Conclusion

This case highlights the importance of careful consideration of ACF-dAVF draining posteriorly via the olfactory vein, which may lead to differential diagnosis of basal ganglia hemorrhage.

背景前颅窝硬脑膜动静脉瘘(ACF-dAVF)通常经皮质静脉引流至上矢状窦(SSS)。在此,我们报告了一例以前未报道过的以基底节出血为临床症状的 ACF-dAVF 病例,瘘管经由嗅静脉、罗森塔尔基底静脉和盖伦静脉向后引流至直窦。引流静脉阻塞导致罗森塔尔基底静脉中段形成静脉球,最终引起基底节出血。
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引用次数: 0
Association between glucose-to-lymphocyte ratio and short-term mortality in critically ill subarachnoid hemorrhage patients: A retrospective cohort study 重症蛛网膜下腔出血患者葡萄糖与淋巴细胞比率与短期死亡率之间的关系:回顾性队列研究
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.01.001

Objective

We aimed to evaluate the association between admission glucose-to-lymphocyte ratio (GLR) and 28-day all-cause mortality in critically ill patients with non-traumatic SAH.

Methods

Data were extracted from the Medical Information Mart for Intensive Care IV database. The primary outcome was 28-day all-cause mortality. Cox regression analysis, Kaplan-Meier curves, restricted cubic spline curves, subgroup analysis and sensitivity analysis were used to assess the relationship between GLR and patient outcome.

Results

A total of 530 patients were included in this study. The Kaplan-Meier curves demonstrated that SAH patients in the high-GLR group (GLR ≧7.4) had a lower 28-day survival rate. A linear relationship was found between GLR and 28-day mortality. Multivariable Cox regression revealed that admission GLR was independently associated with 28-day mortality in critically ill SAH patients (hazard ratio [HR] = 1.03, 95 % confidence interval [CI] = 1.01–1.06, P = 0.011). SAH patients in the high-GLR group had a higher risk of 28-day mortality, compared with those in the low-GLR group (HR = 1.62, 95 % CI = 1.10–2.37, P = 0.015). Subgroup and sensitivity analyses supported the robustness of our results.

Conclusion

High GLR levels at admission were associated with increased 28-day all-cause mortality in critically ill SAH patients.

目的我们旨在评估非创伤性 SAH 重症患者入院时葡萄糖与淋巴细胞比值(GLR)与 28 天全因死亡率之间的关系。主要结果是28天的全因死亡率。采用 Cox 回归分析、Kaplan-Meier 曲线、限制性三次样条曲线、亚组分析和敏感性分析来评估 GLR 与患者预后之间的关系。Kaplan-Meier曲线显示,高GLR组(GLR≧7.4)SAH患者的28天生存率较低。GLR与28天死亡率之间存在线性关系。多变量 Cox 回归显示,入院 GLR 与重症 SAH 患者的 28 天死亡率密切相关(危险比 [HR] = 1.03,95% 置信区间 [CI] = 1.01-1.06,P = 0.011)。与低GLR组相比,高GLR组SAH患者的28天死亡风险更高(HR = 1.62,95 % CI = 1.10-2.37,P = 0.015)。结论入院时 GLR 水平高与 SAH 重症患者 28 天全因死亡率增加有关。
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引用次数: 0
The function of astrocytes in cerebral infarction and potential therapeutic approaches 星形胶质细胞在脑梗塞中的功能及潜在治疗方法
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-08-01 DOI: 10.1016/j.hest.2024.03.003

Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo activation, transforming into reactive astrocytes, ultimately leading to the formation of glial scars. These scars play a crucial role in the intricate process of brain injury. Given their involvement in neuroprotection, regulation of scarring, facilitation of nerve regeneration, preservation of the blood–brain barrier, promotion of angiogenesis, and modulation of the immune response post-cerebral infarction, researchers have proposed an array of therapeutic strategies directed towards targeting astrocytes. This review delves into the beneficial functions of reactive astrocytes in the context of cerebral infarction, exploring corresponding treatment strategies that capitalize on these insights.

星形胶质细胞是中枢神经系统中最常见的细胞,对大脑的正常生理功能起着重要作用。脑梗塞发生后,这些星形胶质细胞会发生活化,转变为反应性星形胶质细胞,最终形成胶质疤痕。这些疤痕在错综复杂的脑损伤过程中起着至关重要的作用。鉴于星形胶质细胞参与神经保护、疤痕调节、促进神经再生、保护血脑屏障、促进血管生成以及调节脑梗塞后的免疫反应,研究人员提出了一系列针对星形胶质细胞的治疗策略。本综述深入探讨了反应性星形胶质细胞在脑梗塞中的有益功能,并利用这些见解探讨了相应的治疗策略。
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引用次数: 0
Immune system perspective in intracerebral hemorrhage Research: A focus on monocytes and Macrophages 脑出血研究中的免疫系统视角:聚焦单核细胞和巨噬细胞
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.hest.2024.07.004
Hang Hang, Lei Huang, Yuan-hong Mao, Guofeng Wu
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引用次数: 0
Step-down infusion of barbiturate improves neurofunction in a new rat model of rebleeding subarachnoid hemorrhage 降压输注巴比妥酸盐可改善蛛网膜下腔出血再出血新模型大鼠的神经功能
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.hest.2024.07.001
Sosho Kajiwara, Yu Hasegawa, Kana Fujimori, Motohiro Morioka
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引用次数: 0
Mixed-reality head-mounted display in cranial neurosurgery: A proof-of-concept study 混合现实头戴式显示器在头颅神经外科手术中的应用:概念验证研究
IF 1.3 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-01 DOI: 10.1016/j.hest.2024.07.003
Lukas Andereggen, G. Boillat, J. Haegler, Philipp Gruber, Basil Erwin Grüter, S. Wanderer, Angelo Tortora, Gerrit A. Schubert, Hans-Jakob Steiger, Serge Marbacher
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引用次数: 0
Inflammation in intracerebral hemorrhage: A bibliometric perspective 脑出血中的炎症:文献计量学视角
Q2 Medicine Pub Date : 2024-06-01 DOI: 10.1016/j.hest.2024.01.003
Rui Zhang , Ruoqi Ding , Qiao Wang , Linke Zhang , Xiaochong Fan , Fuyou Guo , Xuemei Chen , Chao Jiang , Jing Cao , Junmin Wang , Weidong Zang , Jian Wang

Objective

Intracerebral hemorrhage (ICH) is a severe stroke that can adversely affect patient outcomes due to the accompanying inflammatory response. As a result, there is a growing interest in studying inflammation in ICH. We systematically reviewed relevant articles using the Web of Science to understand the literature on this subject. This study aims to provide a comprehensive overview of the field through bibliometric analysis, highlight its current status, identify frontiers, and speculate on future directions.

Methods

We conducted a bibliometric analysis of the global English literature on inflammation related to ICH research based on the Web of Science from 1993 to the present to address publication trends and research hotspots.

Results

A total of 885 publications were included from 1993 to 2023. These articles were authored by 7375 researchers from 1639 organizations in 68 countries and published in 571 journals. Collectively, they cited 48,980 references from 5621 journals. The author who published the most articles was Dr. Zhang, John H. Interestingly, 6 of the top ten most published authors were from China. Regarding the countries that published the most articles, China was at the top of the list, followed by the United States. The most frequently used keywords were “Inflammation”, “Neuroinflammation”, and “Microglia”. Regarding journal publication and reference citations, Stroke was the most published and cited journal.

Conclusions

Over the past 30 years, there has been considerable progress in scientific research concerning inflammation in the context of ICH. The pivotal themes of these studies have been immune cells and inflammatory mediators. It is worth noting, however, that most of the published literature on inflammation in ICH pertains to preclinical studies, with comparatively fewer clinical investigations. Several challenges must be addressed to translate these promising research achievements into clinical practice.

目的脑出血(ICH)是一种严重的中风,由于伴随的炎症反应会对患者的预后产生不利影响。因此,人们对研究 ICH 中的炎症越来越感兴趣。我们利用 "科学网 "系统地查阅了相关文章,以了解有关这一主题的文献。本研究旨在通过文献计量学分析对该领域进行全面概述,突出其现状,确定前沿领域,并推测未来的研究方向。方法我们基于科学网对 1993 年至今与 ICH 研究相关的炎症方面的全球英文文献进行了文献计量学分析,以探讨出版趋势和研究热点。结果从 1993 年到 2023 年,共收录了 885 篇出版物。这些文章由来自 68 个国家 1639 个组织的 7375 名研究人员撰写,发表在 571 种期刊上。这些文章共引用了 5621 种期刊中的 48980 篇参考文献。有趣的是,发表文章最多的前十名作者中有六位来自中国。关于发表文章最多的国家,中国位居榜首,其次是美国。最常使用的关键词是 "炎症"、"神经炎症 "和 "小胶质细胞"。在期刊发表和参考文献引用方面,《卒中》是发表和引用最多的期刊。这些研究的核心主题是免疫细胞和炎症介质。但值得注意的是,已发表的有关 ICH 炎症的文献大多涉及临床前研究,临床研究相对较少。要将这些充满希望的研究成果转化为临床实践,必须应对几个挑战。
{"title":"Inflammation in intracerebral hemorrhage: A bibliometric perspective","authors":"Rui Zhang ,&nbsp;Ruoqi Ding ,&nbsp;Qiao Wang ,&nbsp;Linke Zhang ,&nbsp;Xiaochong Fan ,&nbsp;Fuyou Guo ,&nbsp;Xuemei Chen ,&nbsp;Chao Jiang ,&nbsp;Jing Cao ,&nbsp;Junmin Wang ,&nbsp;Weidong Zang ,&nbsp;Jian Wang","doi":"10.1016/j.hest.2024.01.003","DOIUrl":"10.1016/j.hest.2024.01.003","url":null,"abstract":"<div><h3>Objective</h3><p>Intracerebral hemorrhage (ICH) is a severe stroke that can adversely affect patient outcomes due to the accompanying inflammatory response. As a result, there is a growing interest in studying inflammation in ICH. We systematically reviewed relevant articles using the Web of Science to understand the literature on this subject. This study aims to provide a comprehensive overview of the field through bibliometric analysis, highlight its current status, identify frontiers, and speculate on future directions.</p></div><div><h3>Methods</h3><p>We conducted a bibliometric analysis of the global English literature on inflammation related to ICH research based on the Web of Science from 1993 to the present to address publication trends and research hotspots.</p></div><div><h3>Results</h3><p>A total of 885 publications were included from 1993 to 2023. These articles were authored by 7375 researchers from 1639 organizations in 68 countries and published in 571 journals. Collectively, they cited 48,980 references from 5621 journals. The author who published the most articles was Dr. Zhang, John H. Interestingly, 6 of the top ten most published authors were from China. Regarding the countries that published the most articles, China was at the top of the list, followed by the United States. The most frequently used keywords were “Inflammation”, “Neuroinflammation”, and “Microglia”. Regarding journal publication and reference citations, <em>Stroke</em> was the most published and cited journal.</p></div><div><h3>Conclusions</h3><p>Over the past 30 years, there has been considerable progress in scientific research concerning inflammation in the context of ICH. The pivotal themes of these studies have been immune cells and inflammatory mediators. It is worth noting, however, that most of the published literature on inflammation in ICH pertains to preclinical studies, with comparatively fewer clinical investigations. Several challenges must be addressed to translate these promising research achievements into clinical practice.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000032/pdfft?md5=e606002c1b01e2943d2bc866dd64d591&pid=1-s2.0-S2589238X24000032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139537216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Brain Hemorrhages
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