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Footprint medialization with bone marrow stimulation versus conventional incomplete repair for chronic retracted rotator cuff tears. 骨髓刺激介导与传统不完全修复治疗慢性肩袖撕裂。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI: 10.5397/cise.2025.00017
Jung-Taek Hwang
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引用次数: 0
Surgical technique for secondary pectoralis major transfer after reverse total shoulder arthroplasty to treat residual internal rotation dysfunction. 反向全肩关节置换术后继发胸大肌转移治疗残余内旋功能障碍的手术技术。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2024-12-02 DOI: 10.5397/cise.2024.00542
Chang Hee Baek, Bo Taek Kim, Jung Gon Kim

Reverse total shoulder arthroplasty (RSA) has emerged as a promising treatment option for rotator cuff tear arthropathy. However, concerns persist regarding horizontal rotational dysfunction after RSA. While many studies focus on improving external rotation after RSA, limited attention has been paid to internal rotation. In this technical note, we describe how to perform secondary pectoralis major transfer in a patient with residual internal rotation dysfunction after RSA.

反向全肩关节置换术(RSA)已成为一种有前途的治疗选择肩袖撕裂关节病。然而,对于RSA术后水平旋转功能障碍的担忧仍然存在。虽然许多研究关注于RSA后改善外旋,但对内旋的关注有限。在这篇技术笔记中,我们描述了如何对RSA术后残留内旋功能障碍患者进行继发性胸大肌转移。
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引用次数: 0
Effectiveness of a combined arthroscopic and antibiotic-impregnated bead approach for septic shoulder arthritis management: a case series. 联合关节镜和抗生素浸渍头方法对脓毒性肩关节关节炎管理的有效性:一个病例系列。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-17 DOI: 10.5397/cise.2024.00584
Sung-Jin Park, Sam-Guk Park

Background: This study sought to evaluate the effectiveness of a combined treatment approach for septic shoulder arthritis involving arthroscopic synovectomy and use of antibiotic-impregnated polymethylmethacrylate (PMMA) beads for localized antibiotic delivery.

Methods: This retrospective study included 22 patients with septic shoulder arthritis treated at our institution between 2017 and 2023. The treatment involved arthroscopic lavage, debridement, and insertion of antibiotic-impregnated PMMA beads. Patients were evaluated preoperatively and postoperatively based on laboratory tests, imaging, joint fluid analysis, and physical examination. Treatment efficacy was assessed based on normalization of C-reactive protein (CRP) levels, pain reduction as measured using a visual analog scale (VAS), and improvement in shoulder function according to Constant-Murley score.

Results: All 22 patients demonstrated successful resolution of infection, with only one case of recurrence, leading to a notably low recurrence rate of 5%. Recurrence was determined based on clinical signs (aggravated pain, swelling, and fever) and laboratory markers (elevated CRP and white blood cell count). Mean follow-up duration was 20.2 months. Significant reductions in pain (average VAS score reduction from 8.1 to 2.4, P<0.001) were observed, and mean Constant-Murley score at final follow-up was 60.7, reflecting improved shoulder function.

Conclusions: Arthroscopic debridement combined with localized antibiotic delivery using PMMA beads is an effective and safe treatment for septic shoulder arthritis. This method offers substantial advantages over traditional treatments, as evidenced by the very low recurrence rate. Level of evidence: IV.

背景:本研究旨在评估化脓性肩关节关节炎的联合治疗方法的有效性,包括关节镜下滑膜切除术和使用抗生素浸渍的聚甲基丙烯酸甲酯(PMMA)微球进行局部抗生素输送。方法:本回顾性研究纳入了2017年至2023年在我院治疗的22例脓毒性肩关节关节炎患者。治疗包括关节镜灌洗,清创,并插入抗生素浸渍PMMA珠。术前和术后根据实验室检查、影像学、关节液分析和体格检查对患者进行评估。根据c反应蛋白(CRP)水平的正常化、视觉模拟量表(VAS)测量的疼痛减轻以及根据Constant-Murley评分的肩部功能改善来评估治疗效果。结果:22例患者均成功治愈感染,仅有1例复发,复发率低至5%。根据临床症状(疼痛加重、肿胀和发热)和实验室标志物(CRP和白细胞计数升高)确定复发。平均随访时间为20.2个月。疼痛明显减轻(VAS平均评分从8.1降至2.4)。结论:关节镜下清创联合PMMA微球局部给药是治疗脓毒性肩关节关节炎的有效、安全的方法。这种方法比传统的治疗方法有很大的优势,复发率很低。证据等级:四级。
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引用次数: 0
Platelet rich plasma versus corticosteroids for lateral epicondylitis: a meta-analysis of randomized clinical trials. 富血小板血浆与皮质类固醇治疗外侧上髁炎:随机临床试验的荟萃分析。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.5397/cise.2024.00801
Ralph Maroun, Mohammad Daher, Peter Boufadel, Ryan Lopez, Adam Z Khan, Joseph A Abboud

Background: Lateral epicondylitis, colloquially known as tennis elbow, is a common cause of elbow pain and daily task disability. Caused by repetitive movement, it is typically a degenerative rather than inflammatory event and affects mostly middle-aged patients. Despite its good prognostic nature, its economic burden on the healthcare system encourages research on the efficacity of non-operative injection treatments. This article aims to compare the clinical effectiveness of platelet-rich plasma (PRP) and corticosteroid (CS) injections in managing lateral epicondylitis.

Methods: PubMed, Cochrane, and Google Scholar (pages 1-20) were searched up to March 2024. Only randomized controlled trials were included. The clinical outcomes evaluated were the visual analog scale (VAS) and Disabilities of the Arm, Shoulder, and Hand (DASH) score.

Results: Twenty-six randomized controlled trials with 1.877 patients were included in this meta-analysis. In terms of VAS scores, short-term results (<2 months) favored CS over PRP (P=0.03; mean difference [MD], 0.67; 95% CI, 0.05 to 1.28), whereas long-term results (>6 months) favored PRP (P<0.001; MD, -1.60; 95% CI, -2.01 to -1.20]). Intermediate-term results (2-6 months) showed no significant difference between injection treatments. In terms of DASH scores, short- and intermediate-term results showed no significant difference, whereas long-term results favored PRP (P<0.001; MD, -4.87; 95% CI, -7.69 to -2.06).

Conclusions: CS provides significantly better short-term pain relief, while PRP provides better long-term functional improvement and clinical long-term pain relief. However, future studies should focus on other injection protocols or addition of other non-invasive modalities. Level of evidence: I.

背景:外侧上髁炎,俗称网球肘,是肘部疼痛和日常工作障碍的常见原因。由重复运动引起,它通常是一种退行性而不是炎症性事件,主要影响中年患者。尽管它具有良好的预后性质,但它对医疗保健系统的经济负担鼓励了对非手术注射治疗有效性的研究。本文旨在比较富血小板血浆(PRP)和皮质类固醇(CS)注射治疗外侧上髁炎的临床疗效。方法:检索截至2024年3月的PubMed、Cochrane和谷歌Scholar(第1-20页)。仅纳入随机对照试验。临床结果评估为视觉模拟量表(VAS)和臂、肩、手残疾(DASH)评分。结果:26项随机对照试验纳入了1877例患者。在VAS评分方面,短期结果(6个月)偏向于PRP(结论:CS能明显改善短期疼痛,而PRP能更好地改善长期功能和临床长期疼痛。然而,未来的研究应侧重于其他注射方案或增加其他非侵入性方式。证据等级:1。
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引用次数: 0
Outcomes of footprint medialization and bone marrow stimulation in chronic retracted rotator cuff tears. 足印介导和骨髓刺激治疗慢性后缩性肩袖撕裂的疗效。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-14 DOI: 10.5397/cise.2024.00689
Hyoung Bok Kim, Seong Hun Kim

Background: This study compared the clinical and radiological outcomes of chronic retracted rotator cuff tears where complete footprint coverage cannot be achieved, using two treatments: footprint medialization with bone marrow stimulation and conventional incomplete repair.

Methods: This retrospective study included 87 patients who underwent arthroscopic rotator cuff repair with incomplete footprint coverage. The included patients were divided into group 1 (54 patients with footprint medialization and bone marrow stimulation) and group 2 (33 patients with conventional repair). Medialization and bone marrow stimulation were performed if the tendon did not cover a footprint of ≥1 cm2. Clinical outcomes, including a visual analog scale for pain score, range of motion, American Shoulder and Elbow Surgeons score, Constant-Murley score, and patient satisfaction, were evaluated preoperatively and at follow-up. Radiological healing was assessed using magnetic resonance imaging or computed tomography arthrography at 6 months and ultrasound at 2 years.

Results: Both groups showed significant improvements in clinical outcomes from preoperative levels. Group 1 demonstrated better outcomes in all measures at the final follow-up than group 2. Active range of motion improved significantly in both groups, with no significant postoperative differences. At 2 years postoperatively, group 1 had a significantly lower retear rate (14.8%) than group 2 (36.4%) (P=0.020).

Conclusions: In this study, the group that underwent footprint medialization and bone marrow stimulation for chronic retracted rotator cuff tears, in which complete footprint coverage was not possible, exhibited a lower retear rate and better clinical outcomes than the group that underwent conventional incomplete repair, with a minimum follow-up period of 2 years. Level of evidence: III.

背景:本研究比较了慢性挛缩性肩袖撕裂的临床和影像学结果,在这种情况下,无法实现足印完全覆盖,采用两种治疗方法:骨髓刺激足印介导和常规不完全修复。方法:本回顾性研究纳入87例关节镜下肩袖修复术患者。纳入的患者分为1组(54例足迹介质化+骨髓刺激)和2组(33例常规修复)。如果肌腱没有覆盖≥1 cm2的足迹,则进行介导和骨髓刺激。术前和随访时评估临床结果,包括疼痛评分、活动范围、美国肩关节外科医生评分、Constant-Murley评分和患者满意度的视觉模拟量表。放射学愈合在6个月时使用磁共振成像或计算机断层关节摄影进行评估,在2年时使用超声进行评估。结果:两组临床结果均较术前水平有显著改善。在最后的随访中,组1的各项指标均优于组2。两组患者的活动范围均有明显改善,术后无明显差异。术后2年,组1的复发率(14.8%)明显低于组2 (36.4%)(P=0.020)。结论:在本研究中,在不可能完全覆盖足印的情况下,接受足印介导和骨髓刺激治疗慢性挛缩性肩袖撕裂的组比接受常规不完全修复的组表现出更低的恢复率和更好的临床结果,随访时间至少为2年。证据水平:III。
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引用次数: 0
Current concepts in arthroscopic rotator cuff repair. 关节镜下肩袖修复的最新概念。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-17 DOI: 10.5397/cise.2025.00010
Kang-San Lee, Dong-Hyun Kim, Seok Won Chung, Jong Pil Yoon

Rotator cuff repair has experience great development, transitioning from open surgical techniques to minimally invasive arthroscopic methods. This review explores its historical development, current repair techniques, biomechanical considerations, and advances in materials and biological augmentation. It also addresses strategies for managing partial-thickness and massive tears, compares single-row and double-row repairs, and highlights the importance of individualized postoperative rehabilitation. By integrating biomechanical precision with biological innovations, modern rotator cuff repair aims to improve healing rates, reduce retear risk, and optimize functional outcomes.

肩袖修复经历了很大的发展,从开放手术技术过渡到微创关节镜方法。本文综述了其历史发展、目前的修复技术、生物力学方面的考虑以及材料和生物增强技术的进展。它还讨论了处理部分厚度和大量撕裂的策略,比较单排和双排修复,并强调个性化术后康复的重要性。通过将生物力学精度与生物学创新相结合,现代肩袖修复旨在提高愈合率,降低复发风险,并优化功能结果。
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引用次数: 0
Acute complications after reverse total shoulder arthroplasty for treatment of cuff arthropathy versus fracture. 反向全肩关节置换术治疗袖带关节病与骨折的急性并发症。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.5397/cise.2024.00766
Chase T Nelson, Isabel Shaffrey, James Satalich, Haleigh Hopper, Conor O'Neill, Carl Edge, Brady Ernst, Jennifer L Vanderbeck

Background: Reverse total shoulder arthroplasty (RTSA) has become increasingly popular in recent years, and this trend is expected to continue. However, differences in outcomes of RTSA for fractures compared with other indications are poorly understood. This study aimed to identify the compare the incidences of adverse events during RTSA to treat cuff tear arthropathy (CTA) versus RTSA to treat fractures, as well as identify risk factors for any adverse event.

Methods: Patients who underwent RTSA from 2010 to 2020 in the National Surgical Quality Improvement Program database were included. Matched cohorts were created using nearest-neighbor matching. Independent sample t-tests and chi-square tests were used to determine differences between groups, and binary logistic regression was performed to determine odds ratios and 95% CIs.

Results: In total, 27,607 CTA patients (94.5%) and 1,537 fracture patients (5.3%) underwent RTSA. Adverse events occurred in 1,088 CTA patients (3.9%) and 192 fracture patients (12.4%). Incidences of adverse events, postoperative transfusions, and returns to an operating room were all significantly higher in the fracture cohort compared with CTA patients.

Conclusions: Following surgery, higher rates of adverse events were observed in the CTA patients compared with those in the fracture cohort. These findings improve our understanding of the effectiveness of an increasingly popular surgical intervention due to the use of a large database analysis to identify short-term complications and risk factors. Level of evidence: III.

背景:逆行全肩关节置换术(RTSA)近年来越来越流行,这一趋势预计将持续下去。然而,与其他适应症相比,RTSA治疗骨折的结果差异尚不清楚。本研究旨在确定RTSA治疗袖带撕裂性关节病(CTA)与RTSA治疗骨折期间不良事件发生率的比较,并确定任何不良事件的危险因素。方法:纳入2010 - 2020年国家外科质量改进计划数据库中接受RTSA的患者。使用最近邻匹配创建匹配队列。采用独立样本t检验和卡方检验确定组间差异,采用二元logistic回归确定优势比和95% ci。结果:共27,607例CTA患者(94.5%)和1,537例骨折患者(5.3%)接受了RTSA。不良事件发生在1088例CTA患者(3.9%)和192例骨折患者(12.4%)。与CTA患者相比,骨折组的不良事件、术后输血和返回手术室的发生率均显著高于CTA患者。结论:手术后,CTA患者的不良事件发生率高于骨折患者。由于使用了大型数据库分析来识别短期并发症和危险因素,这些发现提高了我们对日益流行的手术干预的有效性的理解。证据水平:III。
{"title":"Acute complications after reverse total shoulder arthroplasty for treatment of cuff arthropathy versus fracture.","authors":"Chase T Nelson, Isabel Shaffrey, James Satalich, Haleigh Hopper, Conor O'Neill, Carl Edge, Brady Ernst, Jennifer L Vanderbeck","doi":"10.5397/cise.2024.00766","DOIUrl":"10.5397/cise.2024.00766","url":null,"abstract":"<p><strong>Background: </strong>Reverse total shoulder arthroplasty (RTSA) has become increasingly popular in recent years, and this trend is expected to continue. However, differences in outcomes of RTSA for fractures compared with other indications are poorly understood. This study aimed to identify the compare the incidences of adverse events during RTSA to treat cuff tear arthropathy (CTA) versus RTSA to treat fractures, as well as identify risk factors for any adverse event.</p><p><strong>Methods: </strong>Patients who underwent RTSA from 2010 to 2020 in the National Surgical Quality Improvement Program database were included. Matched cohorts were created using nearest-neighbor matching. Independent sample t-tests and chi-square tests were used to determine differences between groups, and binary logistic regression was performed to determine odds ratios and 95% CIs.</p><p><strong>Results: </strong>In total, 27,607 CTA patients (94.5%) and 1,537 fracture patients (5.3%) underwent RTSA. Adverse events occurred in 1,088 CTA patients (3.9%) and 192 fracture patients (12.4%). Incidences of adverse events, postoperative transfusions, and returns to an operating room were all significantly higher in the fracture cohort compared with CTA patients.</p><p><strong>Conclusions: </strong>Following surgery, higher rates of adverse events were observed in the CTA patients compared with those in the fracture cohort. These findings improve our understanding of the effectiveness of an increasingly popular surgical intervention due to the use of a large database analysis to identify short-term complications and risk factors. Level of evidence: III.</p>","PeriodicalId":33981,"journal":{"name":"Clinics in Shoulder and Elbow","volume":"28 1","pages":"77-84"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic accuracy of clinical tests after subacromial lidocaine injection and ultrasonography for evaluating supraspinatus tendon disorder. 肩峰下注射利多卡因及超声检查对冈上肌腱紊乱的诊断准确性。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI: 10.5397/cise.2024.00738
Jansen Lee, Andri Maruli Tua Lubis, Iman Widya Aminata, Renaldi Prasetia

Background: Accurate pathoanatomic diagnosis of the cause of shoulder pain cannot rely solely on clinical tests. Similarly, diagnosis based on imaging results alone is not reliable due to the high prevalence of asymptomatic pathology. This study aims to assess the diagnostic accuracy of clinical testing with lidocaine injection and ultrasonography as a screening method for detecting supraspinatus disorders compared with magnetic resonance imaging (MRI).

Methods: Patients with supraspinatus-related shoulder pain were collected from outpatient clinics. Clinical tests, ultrasonography, and subacromial lidocaine injections were performed, with tests repeated post-injection. The results were confirmed with MRI findings.

Results: Of 78 patients, the average age was 58±6 years, with 76.9% being normal weight females. Moderate shoulder pain was reported by 75.6% of participants, predominantly on the dominant right side (84.6%), with a significant correlation (P<0.05). The Hawkins-Kennedy test (0.73) and Neer sign (0.68) had the best sensitivity, while the drop arm test (0.93) showed the highest specificity for tendon pathology. For full-thickness tears, the Hawkins-Kennedy and empty can test (0.76) had the best sensitivity, and the drop arm test (0.82) had the best specificity. Lidocaine injection reduced sensitivity but increased specificity, with the drop arm test reaching 0.96. Supraspinatus ultrasonography was over 90% accurate compared with MRI, with a kappa value above 0.7.

Conclusions: Subacromial lidocaine injection reduces sensitivity but increases the specificity of clinical tests for supraspinatus tendon disorders. Ultrasonography can be used as a screening tool for supraspinatus tendon abnormalities. Level of evidence: IV.

背景:对肩痛病因的准确病理诊断不能仅仅依靠临床检查。同样,由于无症状病理的高患病率,仅基于影像学结果的诊断是不可靠的。本研究旨在评价利多卡因注射及超声检查作为冈上肌疾病筛查方法的临床检测与磁共振成像(MRI)的诊断准确性。方法:收集门诊收治的冈上肌相关性肩痛患者。进行临床检查、超声检查和肩峰下利多卡因注射,注射后重复检查。结果与MRI检查结果一致。结果:78例患者平均年龄58±6岁,体重正常的女性占76.9%。75.6%的参与者报告了中度肩痛,主要发生在右侧(84.6%),两者之间存在显著相关性(结论:肩峰下利多卡因注射降低了冈上肌腱疾病临床检查的敏感性,但增加了特异性)。超声检查可作为冈上肌腱异常的筛查工具。证据等级:四级。
{"title":"Diagnostic accuracy of clinical tests after subacromial lidocaine injection and ultrasonography for evaluating supraspinatus tendon disorder.","authors":"Jansen Lee, Andri Maruli Tua Lubis, Iman Widya Aminata, Renaldi Prasetia","doi":"10.5397/cise.2024.00738","DOIUrl":"10.5397/cise.2024.00738","url":null,"abstract":"<p><strong>Background: </strong>Accurate pathoanatomic diagnosis of the cause of shoulder pain cannot rely solely on clinical tests. Similarly, diagnosis based on imaging results alone is not reliable due to the high prevalence of asymptomatic pathology. This study aims to assess the diagnostic accuracy of clinical testing with lidocaine injection and ultrasonography as a screening method for detecting supraspinatus disorders compared with magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Patients with supraspinatus-related shoulder pain were collected from outpatient clinics. Clinical tests, ultrasonography, and subacromial lidocaine injections were performed, with tests repeated post-injection. The results were confirmed with MRI findings.</p><p><strong>Results: </strong>Of 78 patients, the average age was 58±6 years, with 76.9% being normal weight females. Moderate shoulder pain was reported by 75.6% of participants, predominantly on the dominant right side (84.6%), with a significant correlation (P<0.05). The Hawkins-Kennedy test (0.73) and Neer sign (0.68) had the best sensitivity, while the drop arm test (0.93) showed the highest specificity for tendon pathology. For full-thickness tears, the Hawkins-Kennedy and empty can test (0.76) had the best sensitivity, and the drop arm test (0.82) had the best specificity. Lidocaine injection reduced sensitivity but increased specificity, with the drop arm test reaching 0.96. Supraspinatus ultrasonography was over 90% accurate compared with MRI, with a kappa value above 0.7.</p><p><strong>Conclusions: </strong>Subacromial lidocaine injection reduces sensitivity but increases the specificity of clinical tests for supraspinatus tendon disorders. Ultrasonography can be used as a screening tool for supraspinatus tendon abnormalities. Level of evidence: IV.</p>","PeriodicalId":33981,"journal":{"name":"Clinics in Shoulder and Elbow","volume":"28 1","pages":"68-76"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose- and sex-dependent effects on umbilical cord-derived mesenchymal stem cell efficacy in regeneration of a full-thickness tendon defect in a rat model. 剂量和性别依赖性对脐带间充质干细胞再生大鼠全层肌腱缺损的影响。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2025-02-17 DOI: 10.5397/cise.2024.00626
Ji-Hye Yea, Chris Hyunchul Jo

Background: Mesenchymal stem cells (MSCs) have shown potential in regenerative medicine. In the present study the effects of MSC dosage and recipient sex on tendon regeneration were evaluated.

Methods: A full-thickness tendon defect (FTTD) was created on supraspinatus tendons (SSTs) of rats and cryoprotective solution (CPS) and MSCs (0.05, 0.1 and 0.5 million MSCs [M-MSC] for female groups and 1.0 M-MSC for both female and male groups) were applied. After 2 and 4 weeks, macroscopic and histological evaluations were performed.

Results: Total macroscopic scores were improved in all MSC groups compared with the CPS group, with no significant differences among the MSC groups. Furthermore, all MSC groups had lower total degenerative scores than the CPS group; however, only 0.1 M-MSC, 0.5 M-MSC, and 1 M-MSC groups showed significantly improved hyalinization compared with the CPS group at 4 weeks. Collagen organization and coherence were higher in all MSC groups than in the CPS group at both 2 and 4 weeks; however, 0.5 M-MSC and 1 M-MSC groups scored better than the 0.05 M-MSC group at 4 weeks. Heterotopic matrix analysis revealed smaller glycosaminoglycan (GAG)-rich areas in the 0.1 M-MSC, 0.5 M-MSC, and 1 M-MSC groups compared with the CPS group at 4 weeks. Overall, macroscopic and histological evaluations were not significantly different between female and male groups except for GAG-rich area.

Conclusions: The MSC dosage affected collagen and heterotopic matrix formation in a FTTD rat model; however, the efficacy of MSCs (1.0 M dose) in collagen regeneration was not affected based on the sex of the recipient. Level of evidence: I.

背景:间充质干细胞(MSCs)在再生医学中显示出潜力。本研究评价了骨髓间充质干细胞剂量和受体性别对肌腱再生的影响。方法:在大鼠冈上肌腱(SSTs)上制造全层肌腱缺损(FTTD),应用冷冻保护液(CPS)和间充质干细胞(雌性组0.05、10万、50万个MSCs [M-MSC],雌雄组各1.0个M-MSC)。2周和4周后进行宏观和组织学评价。结果:与CPS组相比,所有MSC组的宏观评分均有所提高,MSC组间无显著差异。此外,所有MSC组的退行性评分均低于CPS组;然而,与CPS组相比,只有0.1 M-MSC、0.5 M-MSC和1 M-MSC组在4周时显示出明显改善的透明化。在2周和4周时,所有MSC组的胶原组织和一致性均高于CPS组;但在第4周时,0.5 M-MSC组和1 M-MSC组的评分高于0.05 M-MSC组。异位基质分析显示,与4周时的CPS组相比,0.1 M-MSC、0.5 M-MSC和1 M-MSC组的糖胺聚糖(GAG)富区更小。总体而言,除了gag富集区域外,男女两组间的宏观和组织学评价均无显著差异。结论:间充质干细胞剂量影响FTTD大鼠模型中胶原和异位基质的形成;然而,MSCs (1.0 M剂量)的胶原再生效果不受受体性别的影响。证据等级:1。
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引用次数: 0
Descriptive analysis of total elbow arthroplasty for distal humerus fractures: 30-day complications. 肱骨远端骨折全肘关节置换术的描述性分析:30天并发症。
IF 1.8 Q2 ORTHOPEDICS Pub Date : 2025-03-01 Epub Date: 2024-11-19 DOI: 10.5397/cise.2024.00500
Dany El-Najjar, Apoorva Mehta, Caroline Taber, Puneet Gupta, Joel R Peterson, Brandon Rogalski, Charles M Jobin, David P Trofa

Background: Although functional outcomes of total elbow arthroplasty (TEA) for distal humerus fractures are satisfactory, there is a high rate of complications. This study aims to characterize the 30-day complications, readmissions, and mortality of patients with TEA for distal humerus fractures in a large registry database.

Methods: Patients who underwent TEA for a distal humerus fracture were identified from the 2015 to 2020 ACS-NSQIP (American College of Surgeons National Surgical Quality Improvement Program) database. Baseline demographics, clinical characteristics, and complications including deep vein thrombosis/pulmonary embolus, infection, mortality, readmissions, and reoperations were recorded. Overall, 134 patients (mean age, 73.6 years; mean body mass index, 28.9 kg/m2 ; 88.8% females) were included.

Results: The total complication rate was 21.6% (n=29). The most common complications were unplanned readmission (6.0%), postoperative transfusion (5.2%), unplanned reoperation (3.0%), wound disruption (2.2%), and urinary tract infection (1.5%). The composite infection rate was 3.7%. There were no 30-day events of mortality, sepsis, or cerebral vascular accident. Patients 80 years or older had higher but not significant rates of unplanned readmission (10.2% vs. 3.5%, P=0.116) and reoperation (6.1% vs. 1.2%, P=0.105).

Conclusions: TEA for distal humerus fracture analyzed over 5 years had high rates of 30-day postoperative complications (21.6%), with unplanned readmission, reoperation, and infection being the most common. Level of evidence: IV.

背景:尽管全肘关节置换术(TEA)治疗肱骨远端骨折的功能效果令人满意,但并发症的发生率很高。本研究旨在通过大型登记数据库了解肱骨远端骨折 TEA 患者的 30 天并发症、再入院率和死亡率:从2015年至2020年的ACS-NSQIP(美国外科学院国家外科质量改进计划)数据库中确定了因肱骨远端骨折接受TEA治疗的患者。记录了基线人口统计学、临床特征和并发症,包括深静脉血栓/肺栓塞、感染、死亡率、再入院和再手术。共纳入 134 名患者(平均年龄 73.6 岁;平均体重指数 28.9 kg/m2;88.8% 为女性):结果:总并发症发生率为 21.6%(n=29)。最常见的并发症是计划外再入院(6.0%)、术后输血(5.2%)、计划外再次手术(3.0%)、伤口破坏(2.2%)和尿路感染(1.5%)。综合感染率为 3.7%。30 天内没有发生死亡、败血症或脑血管意外。80岁或以上患者的意外再入院率(10.2% vs. 3.5%,P=0.116)和再次手术率(6.1% vs. 1.2%,P=0.105)较高,但无显著性差异:肱骨远端骨折TEA术后30天并发症发生率较高(21.6%),其中最常见的是计划外再入院、再次手术和感染。证据级别:IV级。
{"title":"Descriptive analysis of total elbow arthroplasty for distal humerus fractures: 30-day complications.","authors":"Dany El-Najjar, Apoorva Mehta, Caroline Taber, Puneet Gupta, Joel R Peterson, Brandon Rogalski, Charles M Jobin, David P Trofa","doi":"10.5397/cise.2024.00500","DOIUrl":"10.5397/cise.2024.00500","url":null,"abstract":"<p><strong>Background: </strong>Although functional outcomes of total elbow arthroplasty (TEA) for distal humerus fractures are satisfactory, there is a high rate of complications. This study aims to characterize the 30-day complications, readmissions, and mortality of patients with TEA for distal humerus fractures in a large registry database.</p><p><strong>Methods: </strong>Patients who underwent TEA for a distal humerus fracture were identified from the 2015 to 2020 ACS-NSQIP (American College of Surgeons National Surgical Quality Improvement Program) database. Baseline demographics, clinical characteristics, and complications including deep vein thrombosis/pulmonary embolus, infection, mortality, readmissions, and reoperations were recorded. Overall, 134 patients (mean age, 73.6 years; mean body mass index, 28.9 kg/m2 ; 88.8% females) were included.</p><p><strong>Results: </strong>The total complication rate was 21.6% (n=29). The most common complications were unplanned readmission (6.0%), postoperative transfusion (5.2%), unplanned reoperation (3.0%), wound disruption (2.2%), and urinary tract infection (1.5%). The composite infection rate was 3.7%. There were no 30-day events of mortality, sepsis, or cerebral vascular accident. Patients 80 years or older had higher but not significant rates of unplanned readmission (10.2% vs. 3.5%, P=0.116) and reoperation (6.1% vs. 1.2%, P=0.105).</p><p><strong>Conclusions: </strong>TEA for distal humerus fracture analyzed over 5 years had high rates of 30-day postoperative complications (21.6%), with unplanned readmission, reoperation, and infection being the most common. Level of evidence: IV.</p>","PeriodicalId":33981,"journal":{"name":"Clinics in Shoulder and Elbow","volume":" ","pages":"9-14"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinics in Shoulder and Elbow
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