Pub Date : 2019-04-29DOI: 10.15279/KPBA.2019.24.2.68
T. Kwon, Keol Lee, K. Lee
Background/Aims: Percutaneous transhepatic cholangioscopy (PTCS) is an effective treatment used for intrahepatic stone in patients who have undergone hepatectomy. There are few reports on natural course in these patients. Thus, we report the long-term results. Methods: We conducted a retrospective study of 19 patients who underwent PTCS after hepatectomy at Samsung Medical Center between January 1998 and December 2014. We investigated patient characteristics and recurrence of biliary complications during follow up period. Then, we analyzed the factors related to recurrence. Results: Indications for PTCS were cholangitis, symptomatic stone, liver abscess and biliary dilatation. Complete stone removal was achieved in 12 patients (63.2%). After receiving PTCS, the recurrence of intrahepatic stone related complication occurred in 52.6% (10/19) of patients during a median follow-up of 4.9 years (range, 1.8-7.8). Complications were cholangitis (5/10, 50%), cholangitis with liver abscess (3/10, 30%), liver abscess (1/10, 10%) and symptomatic stone (1/10, 10%). On univariate analysis, factors including multiple stone involvement, complete stone removal and bile duct stricture were not significantly associated with recurrent biliary complications. Conclusions: PTCS is an effective treatment for complications of recurrent intrahepatic stones in patients who have undergone hepatectomy. However, long term follow-up is necessary because of the recurrence of biliary complications.
{"title":"Effect and Course of Percutaneous Transhepatic Cholangioscopy in Intrahepatic Stone Related Complication after Liver Resection","authors":"T. Kwon, Keol Lee, K. Lee","doi":"10.15279/KPBA.2019.24.2.68","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.2.68","url":null,"abstract":"Background/Aims: Percutaneous transhepatic cholangioscopy (PTCS) is an effective treatment used for intrahepatic stone in patients who have undergone hepatectomy. There are few reports on natural course in these patients. Thus, we report the long-term results. Methods: We conducted a retrospective study of 19 patients who underwent PTCS after hepatectomy at Samsung Medical Center between January 1998 and December 2014. We investigated patient characteristics and recurrence of biliary complications during follow up period. Then, we analyzed the factors related to recurrence. Results: Indications for PTCS were cholangitis, symptomatic stone, liver abscess and biliary dilatation. Complete stone removal was achieved in 12 patients (63.2%). After receiving PTCS, the recurrence of intrahepatic stone related complication occurred in 52.6% (10/19) of patients during a median follow-up of 4.9 years (range, 1.8-7.8). Complications were cholangitis (5/10, 50%), cholangitis with liver abscess (3/10, 30%), liver abscess (1/10, 10%) and symptomatic stone (1/10, 10%). On univariate analysis, factors including multiple stone involvement, complete stone removal and bile duct stricture were not significantly associated with recurrent biliary complications. Conclusions: PTCS is an effective treatment for complications of recurrent intrahepatic stones in patients who have undergone hepatectomy. However, long term follow-up is necessary because of the recurrence of biliary complications.","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121573403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-29DOI: 10.15279/KPBA.2019.24.2.73
Sang Hoo Lee, J. H. Jun, Y. Doh, J. Jang, S. Kim, I. Baek, S. Jung
Most cases of hypertriglyceridemia (HTG)-induced gestational pancreatitis occur when a person with hyperlipidemia is overweight due to pregnancy or has secondary triggers associated with triglycerides (TGs). In Korea, 6 cases of HTG-induced gestational pancreatitis have been reported, but none of the affected patients had TG levels below 1,000 mg/dL. A 36-year-old female at 30 weeks of gestation was admitted due to pain in her upper abdomen. Initial biochemical analysis revealed a TG level of 260 mg/dL, an amylase level of 2,951 U/L and a lipase level of 3,500 U/L. Abdominal ultrasonography showed pancreatic swelling with a hypoechogenic rim. After several days, the patient was discharged and had a normal delivery at 38 weeks of gestation. This case report is the first to describe acute pancreatitis occurring in the presence of type IV hyperlipoproteinemia even though the TG level was less than 500 mg/dL, contrary to findings in previously reported cases. Korean J Pancreas Biliary Tract 2019;24(2):73-78
{"title":"Acute Pancreatitis in a Pregnant Patient with Type IV Hyperlipoproteinemia","authors":"Sang Hoo Lee, J. H. Jun, Y. Doh, J. Jang, S. Kim, I. Baek, S. Jung","doi":"10.15279/KPBA.2019.24.2.73","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.2.73","url":null,"abstract":"Most cases of hypertriglyceridemia (HTG)-induced gestational pancreatitis occur when a person with hyperlipidemia is overweight due to pregnancy or has secondary triggers associated with triglycerides (TGs). In Korea, 6 cases of HTG-induced gestational pancreatitis have been reported, but none of the affected patients had TG levels below 1,000 mg/dL. A 36-year-old female at 30 weeks of gestation was admitted due to pain in her upper abdomen. Initial biochemical analysis revealed a TG level of 260 mg/dL, an amylase level of 2,951 U/L and a lipase level of 3,500 U/L. Abdominal ultrasonography showed pancreatic swelling with a hypoechogenic rim. After several days, the patient was discharged and had a normal delivery at 38 weeks of gestation. This case report is the first to describe acute pancreatitis occurring in the presence of type IV hyperlipoproteinemia even though the TG level was less than 500 mg/dL, contrary to findings in previously reported cases. Korean J Pancreas Biliary Tract 2019;24(2):73-78","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128768281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-29DOI: 10.15279/KPBA.2019.24.2.55
S. Park
Sex and gender medicine investigates the impact of sex and gender differences on normal conditions, pathogenesis, and clinical features of diseases. By considering sex and gender differences during diagnosis, treatment and prevention, a person can receive the best individualized treatment based on scientific evidence. In this review, sex and gender differences in the field of pancreatobiliary diseases are described regarding gallstones, acute cholecystitis, acute and chronic pancreatitis, and cancers of the pancreas and biliary tract. In addition, recent policy on clinical and preclinical research which states that sex and gender analysis should be included during planning, conducting, and interpretation of the researches and websites containing resources about sex and gender medicine are introduced. This review highlights the importance of considering sex and gender aspect in research, clinics, and medical education.
{"title":"Sex and Gender Medicine in Pancreatobiliary Diseases","authors":"S. Park","doi":"10.15279/KPBA.2019.24.2.55","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.2.55","url":null,"abstract":"Sex and gender medicine investigates the impact of sex and gender differences on normal conditions, pathogenesis, and clinical features of diseases. By considering sex and gender differences during diagnosis, treatment and prevention, a person can receive the best individualized treatment based on scientific evidence. In this review, sex and gender differences in the field of pancreatobiliary diseases are described regarding gallstones, acute cholecystitis, acute and chronic pancreatitis, and cancers of the pancreas and biliary tract. In addition, recent policy on clinical and preclinical research which states that sex and gender analysis should be included during planning, conducting, and interpretation of the researches and websites containing resources about sex and gender medicine are introduced. This review highlights the importance of considering sex and gender aspect in research, clinics, and medical education.","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129003296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-29DOI: 10.15279/KPBA.2019.24.2.47
E. Choi
A primary mission of the Korean pancreatobiliary association (KPBA) is to promote high quality patient care and safety in the field of pancreatobiliary diseases. Among these, endoscopic retrograde cholangiopancreatography (ERCP) is one of the most important procedure among various endoscopic procedures. The purpose of this document is to provide a current Korean medical detailed and departmental specialty system that should be considered before preparing of privileging and credentialing for ERCP subspecialty and making suitable framework for determining the competency of practicing endoscopists and for the granting of privileges to perform ERCP. As such, this document provides current situation of Korean medical specialty and subspecialty system to assist KPBA in making credentialing organizations especially for ERCP subspecialty. Korean J Pancreas Biliary Tract 2019;24(2):47-50
{"title":"Current Korean Medical Specialty and Subspecialty System for Preparation of Privileging and Credentialing of ERCP Subspecialty","authors":"E. Choi","doi":"10.15279/KPBA.2019.24.2.47","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.2.47","url":null,"abstract":"A primary mission of the Korean pancreatobiliary association (KPBA) is to promote high quality patient care and safety in the field of pancreatobiliary diseases. Among these, endoscopic retrograde cholangiopancreatography (ERCP) is one of the most important procedure among various endoscopic procedures. The purpose of this document is to provide a current Korean medical detailed and departmental specialty system that should be considered before preparing of privileging and credentialing for ERCP subspecialty and making suitable framework for determining the competency of practicing endoscopists and for the granting of privileges to perform ERCP. As such, this document provides current situation of Korean medical specialty and subspecialty system to assist KPBA in making credentialing organizations especially for ERCP subspecialty. Korean J Pancreas Biliary Tract 2019;24(2):47-50","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"3186 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127482795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-29DOI: 10.15279/KPBA.2019.24.2.51
C. Paik, S. Ko, K. Cho
An endoscopic retrograde cholangiopancreatography (ERCP) is endoscopically complicated procedure which carries a higher risk of serious adverse events, and it is more challenging compared with general endoscopy. On a national basis, the accepted standards of practice in ERCP are needed to be outlined to ensure consistent clinical standards in patient management. Certificated system for general endoscopy has been implemented since 2006 in Korea. However, an established system for certification of ERCP does not exist, which requires longer training than general endoscopy. Recently, much has been reported about the need to measure and improve the quality of endoscopy services, but still the variability exists in standards used by hospitals for credentialing physicians to ERCP in Korea. There is an urgent need to settle the credentialing process to enhance practice and to protect patients, which suits our society. This article investigated the system of ERCP certification in overseas, and should be helpful to establish the standard certification system of ERCP in Korea. Korean J Pancreas Biliary Tract 2019;24(2):51-54
{"title":"Certificated System for Endoscopic Retrograde Cholangiopancreatography in Foreign Countries","authors":"C. Paik, S. Ko, K. Cho","doi":"10.15279/KPBA.2019.24.2.51","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.2.51","url":null,"abstract":"An endoscopic retrograde cholangiopancreatography (ERCP) is endoscopically complicated procedure which carries a higher risk of serious adverse events, and it is more challenging compared with general endoscopy. On a national basis, the accepted standards of practice in ERCP are needed to be outlined to ensure consistent clinical standards in patient management. Certificated system for general endoscopy has been implemented since 2006 in Korea. However, an established system for certification of ERCP does not exist, which requires longer training than general endoscopy. Recently, much has been reported about the need to measure and improve the quality of endoscopy services, but still the variability exists in standards used by hospitals for credentialing physicians to ERCP in Korea. There is an urgent need to settle the credentialing process to enhance practice and to protect patients, which suits our society. This article investigated the system of ERCP certification in overseas, and should be helpful to establish the standard certification system of ERCP in Korea. Korean J Pancreas Biliary Tract 2019;24(2):51-54","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132039025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-29DOI: 10.15279/KPBA.2019.24.2.84
N. Cho, S. Hwang
Cholecystocolic fistula (CCF) is a rare and late complication of gallbladder disease. The cause of CCF is known to be peptic ulcer, gallbladder disease, malignant tumor, trauma, and postoperative complications. The proper treatment method is to perform cholecystectomy and to identify and alleviate the CCF. However, cholecystectomy is not always possible owing to technical difficulties and disease severity. CCF is difficult to diagnose preoperatively, and CCF operation without an accurate preoperative diagnosis can lead to a more complicated surgery and cause surgeons to face more difficult situations or to endanger patients’ lives. We report a case of asymptomatic CCF successfully treated with laparoscopic surgery after accurate diagnosis before surgery.
{"title":"Asymptomatic Cholecystocolic Fistula Diagnosed Accurately before Surgery","authors":"N. Cho, S. Hwang","doi":"10.15279/KPBA.2019.24.2.84","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.2.84","url":null,"abstract":"Cholecystocolic fistula (CCF) is a rare and late complication of gallbladder disease. The cause of CCF is known to be peptic ulcer, gallbladder disease, malignant tumor, trauma, and postoperative complications. The proper treatment method is to perform cholecystectomy and to identify and alleviate the CCF. However, cholecystectomy is not always possible owing to technical difficulties and disease severity. CCF is difficult to diagnose preoperatively, and CCF operation without an accurate preoperative diagnosis can lead to a more complicated surgery and cause surgeons to face more difficult situations or to endanger patients’ lives. We report a case of asymptomatic CCF successfully treated with laparoscopic surgery after accurate diagnosis before surgery.","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126008119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-31DOI: 10.15279/KPBA.2019.24.1.11
Y. Choi, S. Lee
In acute biliary pancreatitis, endoscopic retrograde cholangiopancreatography (ERCP) and cholecystectomy should be considered to reduce the complications of gallstones including recurrent biliary pancreatitis. If biliary pancreatitis is accompanied by cholangitis or evidence of obvious biliary obstruction, removal of the common bile duct stone via early ERCP (within 24 to 72 hours) is necessary. Less or non-invasive imaging modalities such as endoscopic ultrasound, magnetic resonance cholangiopancreatography can be considered to avoid unnecessary ERCP if suspected biliary obstruction in the absence of cholangitis in patients with biliary pancreatitis. Cholecystectomy in patients with biliary pancreatitis requires a strategy that varies the timing of surgery depending on the severity of pancreatitis. In mild acute biliary pancreatitis, cholecystectomy can be performed safely at the time of initial admission. In moderate to severe biliary pancreatitis, cholecystectomy should be delayed until about 6 weeks when active inflammation subsides and fluid collections resolve or stabilize. Endoscopic sphincterotomy (EST) can be helpful in reducing recurrent pancreatitis in patients who unfit for cholecystectomy. However, even if EST is performed, additional cholecystectomy will further reduce the risk of recurrent pancreatitis, if possible, it is recommended to undergo a cholecystectomy.
{"title":"Indications and Timing of ERCP and Cholecystectomy for Biliary Pancreatitis","authors":"Y. Choi, S. Lee","doi":"10.15279/KPBA.2019.24.1.11","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.1.11","url":null,"abstract":"In acute biliary pancreatitis, endoscopic retrograde cholangiopancreatography (ERCP) and cholecystectomy should be considered to reduce the complications of gallstones including recurrent biliary pancreatitis. If biliary pancreatitis is accompanied by cholangitis or evidence of obvious biliary obstruction, removal of the common bile duct stone via early ERCP (within 24 to 72 hours) is necessary. Less or non-invasive imaging modalities such as endoscopic ultrasound, magnetic resonance cholangiopancreatography can be considered to avoid unnecessary ERCP if suspected biliary obstruction in the absence of cholangitis in patients with biliary pancreatitis. Cholecystectomy in patients with biliary pancreatitis requires a strategy that varies the timing of surgery depending on the severity of pancreatitis. In mild acute biliary pancreatitis, cholecystectomy can be performed safely at the time of initial admission. In moderate to severe biliary pancreatitis, cholecystectomy should be delayed until about 6 weeks when active inflammation subsides and fluid collections resolve or stabilize. Endoscopic sphincterotomy (EST) can be helpful in reducing recurrent pancreatitis in patients who unfit for cholecystectomy. However, even if EST is performed, additional cholecystectomy will further reduce the risk of recurrent pancreatitis, if possible, it is recommended to undergo a cholecystectomy.","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128935744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-31DOI: 10.15279/KPBA.2019.24.1.40
Hanjun Ryu, Hyun-Soo Kim, C. Park, J. Jung, Y. Chung, Jaekwang Lee, Daijin Kim
Endoscopic retrograde cholangiopancreatography (ERCP)-related perforations of the duodenum are rare but serious complications. Some ERCP-related perforations can be successfully managed without surgery. However, the presence of duodenal perforation may lead to premature termination of the ERCP and need for additional procedure such as percutaneous biliary drainage. If the ERCP-related perforation is identified early during the procedure, primary closure of the perforation can be attempted first or after completion of ERCP. We report two cases of duodenal perforation during ERCP in which ERCP was successfully completed after primary closure of the perforation.
{"title":"Two Cases of Successful ERCP during ERCP-Related Iatrogenic Duodenal Perforation","authors":"Hanjun Ryu, Hyun-Soo Kim, C. Park, J. Jung, Y. Chung, Jaekwang Lee, Daijin Kim","doi":"10.15279/KPBA.2019.24.1.40","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.1.40","url":null,"abstract":"Endoscopic retrograde cholangiopancreatography (ERCP)-related perforations of the duodenum are rare but serious complications. Some ERCP-related perforations can be successfully managed without surgery. However, the presence of duodenal perforation may lead to premature termination of the ERCP and need for additional procedure such as percutaneous biliary drainage. If the ERCP-related perforation is identified early during the procedure, primary closure of the perforation can be attempted first or after completion of ERCP. We report two cases of duodenal perforation during ERCP in which ERCP was successfully completed after primary closure of the perforation.","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130072177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-31DOI: 10.15279/KPBA.2019.24.1.1
Jimin Han
Recurrent acute pancreatitis (RAP) is defined as two or more true episodes of acute pancreatitis and about 20% of patients with acute pancreatitis experience at least one episode of recurrence. In about 10% of RAP, no definite etiology is found despite extensive evaluation. This entity is called idiopathic acute pancreatitis (IAP). Toxicmetabolic, idiopathic, genetic, autoimmune, recurrent and severe acute pancreatitis, obstructive (TIGAR-O) classification is commonly used to identify risk factors for RAP. Modalities employed to find causes of RAP and IAP include meticulous history taking, blood tests, diagnostic imaging, genetic testing, bile crystal analysis, endoscopic ultrasonography, and endoscopic retrograde cholangiopancreatography with/ without sphincter of Oddi manometry. Each modality is briefly reviewed in this review.
{"title":"Evaluation of Recurrent or Idiopathic Pancreatitis","authors":"Jimin Han","doi":"10.15279/KPBA.2019.24.1.1","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.1.1","url":null,"abstract":"Recurrent acute pancreatitis (RAP) is defined as two or more true episodes of acute pancreatitis and about 20% of patients with acute pancreatitis experience at least one episode of recurrence. In about 10% of RAP, no definite etiology is found despite extensive evaluation. This entity is called idiopathic acute pancreatitis (IAP). Toxicmetabolic, idiopathic, genetic, autoimmune, recurrent and severe acute pancreatitis, obstructive (TIGAR-O) classification is commonly used to identify risk factors for RAP. Modalities employed to find causes of RAP and IAP include meticulous history taking, blood tests, diagnostic imaging, genetic testing, bile crystal analysis, endoscopic ultrasonography, and endoscopic retrograde cholangiopancreatography with/ without sphincter of Oddi manometry. Each modality is briefly reviewed in this review.","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131253231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-31DOI: 10.15279/KPBA.2019.24.1.17
C. Park
Acute pancreatitis is one of the most common diseases of the pancreas. Although the incidence of acute pancreatitis is increasing, the mortality is decreasing. In general, most of fatal cases occur within 2 weeks after admission due to multi-organ failure. Initial medical treatment of acute pancreatitis is important in order to improve the prognosis of the patients with acute pancreatitis. Essential treatment in this early period includes intravenous hydration, paint control, enteral nutrition, and antimicrobial therapy. Although aggressive intravenous hydration with lactated Ringer’s solution can improve mortality rates and decrease the development of systemic inflammatory response syndrome in the patients with acute pancreatitis, fluid overload can induce pulmonary edema, increase of the extra-pancreatic fluid collection, intra-abdominal compartment syndrome, sepsis, and increase of the mortality. Therefore, goal-directed therapy, utilizing various parameters to guide fluid administration, reduces the risk of persistent single or multiple organ system failure, infected pancreatic necrosis or mortality from acute pancreatitis. Initiation of early oral feeding is recommended, beginning within 24 hours for mild acute pancreatitis. Enteral nutritional support is favored over parental nutrition in severe acute pancreatitis. Recent guidelines do not support the use of prophylactic antibiotics to prevent infection in necrotizing acute pancreatitis and severe acute pancreatitis. Korean J Pancreas Biliary Tract 2019;24(1):17-20
{"title":"Medical Management of Acute Pancreatitis: Intravenous Fluid, Nutrition and Antimicrobial Therapy","authors":"C. Park","doi":"10.15279/KPBA.2019.24.1.17","DOIUrl":"https://doi.org/10.15279/KPBA.2019.24.1.17","url":null,"abstract":"Acute pancreatitis is one of the most common diseases of the pancreas. Although the incidence of acute pancreatitis is increasing, the mortality is decreasing. In general, most of fatal cases occur within 2 weeks after admission due to multi-organ failure. Initial medical treatment of acute pancreatitis is important in order to improve the prognosis of the patients with acute pancreatitis. Essential treatment in this early period includes intravenous hydration, paint control, enteral nutrition, and antimicrobial therapy. Although aggressive intravenous hydration with lactated Ringer’s solution can improve mortality rates and decrease the development of systemic inflammatory response syndrome in the patients with acute pancreatitis, fluid overload can induce pulmonary edema, increase of the extra-pancreatic fluid collection, intra-abdominal compartment syndrome, sepsis, and increase of the mortality. Therefore, goal-directed therapy, utilizing various parameters to guide fluid administration, reduces the risk of persistent single or multiple organ system failure, infected pancreatic necrosis or mortality from acute pancreatitis. Initiation of early oral feeding is recommended, beginning within 24 hours for mild acute pancreatitis. Enteral nutritional support is favored over parental nutrition in severe acute pancreatitis. Recent guidelines do not support the use of prophylactic antibiotics to prevent infection in necrotizing acute pancreatitis and severe acute pancreatitis. Korean J Pancreas Biliary Tract 2019;24(1):17-20","PeriodicalId":342618,"journal":{"name":"The Korean Journal of Pancreas and Biliary Tract","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131396349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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