Lazarou investigates the relationship between mitochondria and autophagy.
Lazarou研究了线粒体和自噬之间的关系。
{"title":"Michael Lazarou: Building a body of research","authors":"M. A. O'Donnell","doi":"10.1083/jcb.201911052","DOIUrl":"https://doi.org/10.1083/jcb.201911052","url":null,"abstract":"Lazarou investigates the relationship between mitochondria and autophagy.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134105208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam W. J. Soh, Teunis J. P. van Dam, Alexander J. Stemm-Wolf, Andrew T. Pham, G. Morgan, E. O'Toole, C. Pearson
Soh et al. study the organization of Tetrahymena ciliary arrays. Basal body–associated striated fibers organize motile cilia by promoting basal body orientation, reorientation, and resistance to ciliary forces. To do so, striated fiber length is modulated to ensure connections between neighboring basal bodies and to the cell cortex.
{"title":"Ciliary force-responsive striated fibers promote basal body connections and cortical interactions","authors":"Adam W. J. Soh, Teunis J. P. van Dam, Alexander J. Stemm-Wolf, Andrew T. Pham, G. Morgan, E. O'Toole, C. Pearson","doi":"10.1083/jcb.201904091","DOIUrl":"https://doi.org/10.1083/jcb.201904091","url":null,"abstract":"Soh et al. study the organization of Tetrahymena ciliary arrays. Basal body–associated striated fibers organize motile cilia by promoting basal body orientation, reorientation, and resistance to ciliary forces. To do so, striated fiber length is modulated to ensure connections between neighboring basal bodies and to the cell cortex.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131798960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband
Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicles between somatodendritic and axonal compartments. Torii et al. show that NuMA1 is transiently located at the AIS and promotes rapid AIS assembly by inhibiting the endocytosis of neurofascin-186.
{"title":"NuMA1 promotes axon initial segment assembly through inhibition of endocytosis","authors":"Tomohiro Torii, Y. Ogawa, Cheng-Hsin Liu, T. Ho, Hamdan Hamdan, Chih-Chuan Wang, J. Oses-Prieto, A. Burlingame, M. Rasband","doi":"10.1083/jcb.201907048","DOIUrl":"https://doi.org/10.1083/jcb.201907048","url":null,"abstract":"Axon initial segments (AISs) initiate action potentials and regulate the trafficking of vesicles between somatodendritic and axonal compartments. Torii et al. show that NuMA1 is transiently located at the AIS and promotes rapid AIS assembly by inhibiting the endocytosis of neurofascin-186.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116936445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Getting under the skin: Cuticle damage elicits systemic autophagy response in C. elegans","authors":"Caroline Kumsta, M. Hansen","doi":"10.1083/jcb.201911020","DOIUrl":"https://doi.org/10.1083/jcb.201911020","url":null,"abstract":"Kumsta and Hansen highlight new findings from Zhang and Zhang exploring how local cellular stress triggers autophagy in distant tissues.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"40 7-8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120897815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Celetti, G. Paci, Joana Caria, V. Vandelinder, G. Bachand, E. Lemke
Nuclear pore complexes form a permeability barrier in vivo that regulates nucleocytoplasmic transport. Here, the authors present a microfluidic device that couples rapid liquid–liquid phase separation of nucleoporins with direct optical interrogation. Freshly formed liquid nucleoporin droplets mimic permeability barrier properties of NPCs.
{"title":"The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes","authors":"G. Celetti, G. Paci, Joana Caria, V. Vandelinder, G. Bachand, E. Lemke","doi":"10.1083/jcb.201907157","DOIUrl":"https://doi.org/10.1083/jcb.201907157","url":null,"abstract":"Nuclear pore complexes form a permeability barrier in vivo that regulates nucleocytoplasmic transport. Here, the authors present a microfluidic device that couples rapid liquid–liquid phase separation of nucleoporins with direct optical interrogation. Freshly formed liquid nucleoporin droplets mimic permeability barrier properties of NPCs.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129263892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epithelial cells are categorized as cuboidal versus squamous based on the height of the lateral membrane. Wang and Brieher show that CD2AP links PI3K activity to actin assembly to extend the height of the lateral membrane.
{"title":"CD2AP links actin to PI3 kinase activity to extend epithelial cell height and constrain cell area","authors":"Y. Wang, W. Brieher","doi":"10.1083/jcb.201812087","DOIUrl":"https://doi.org/10.1083/jcb.201812087","url":null,"abstract":"Epithelial cells are categorized as cuboidal versus squamous based on the height of the lateral membrane. Wang and Brieher show that CD2AP links PI3K activity to actin assembly to extend the height of the lateral membrane.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125393560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derek P. Narendra, C. Guillermier, F. Gyngard, Xiaoping Huang, Michael E. Ward, M. Steinhauser
Narendra et al. demonstrate that APEX can be used as the first genetically encoded reporter for isotope ratio imaging mass spectrometry. Bulk protein turnover is measured in individual lysosomes demonstrating unanticipated heterogeneity among lysosomes within a single cell.
{"title":"Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover","authors":"Derek P. Narendra, C. Guillermier, F. Gyngard, Xiaoping Huang, Michael E. Ward, M. Steinhauser","doi":"10.1083/jcb.201901097","DOIUrl":"https://doi.org/10.1083/jcb.201901097","url":null,"abstract":"Narendra et al. demonstrate that APEX can be used as the first genetically encoded reporter for isotope ratio imaging mass spectrometry. Bulk protein turnover is measured in individual lysosomes demonstrating unanticipated heterogeneity among lysosomes within a single cell.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122253226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nootan Pandey, Daniel Keifenheim, M. Yoshida, Victoria A Hassebroek, Caitlin Soroka, Y. Azuma, D. J. Clarke
To prevent chromosome missegregation, a metaphase checkpoint is activated when topoisomerase II is catalytically inhibited and DNA catenations persist. Pandey et al. dissect the key molecular events triggering this regulatory system.
{"title":"Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases","authors":"Nootan Pandey, Daniel Keifenheim, M. Yoshida, Victoria A Hassebroek, Caitlin Soroka, Y. Azuma, D. J. Clarke","doi":"10.1083/jcb.201807189","DOIUrl":"https://doi.org/10.1083/jcb.201807189","url":null,"abstract":"To prevent chromosome missegregation, a metaphase checkpoint is activated when topoisomerase II is catalytically inhibited and DNA catenations persist. Pandey et al. dissect the key molecular events triggering this regulatory system.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"352 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122847408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DNA replication and mitotic entry: A brake model for cell cycle progression","authors":"B. Lemmens, A. Lindqvist","doi":"10.1083/jcb.201909032","DOIUrl":"https://doi.org/10.1083/jcb.201909032","url":null,"abstract":"Lemmens and Lindqvist discuss how DNA replication and mitosis are coordinated and propose a cell cycle model controlled by brakes.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"38 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120994584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Genetic studies revealed that Abl family kinases interact functionally with microtubules, but the mechanism by which Abl kinases regulate microtubules remains unclear. Hu et al. provide the first evidence that the Abl family kinase Abl2 directly binds microtubules to regulate microtubule dynamics.
{"title":"Regulation of MT dynamics via direct binding of an Abl family kinase","authors":"Yuhan Hu, Wanqing Lyu, L. A. Lowery, A. Koleske","doi":"10.1083/jcb.201812144","DOIUrl":"https://doi.org/10.1083/jcb.201812144","url":null,"abstract":"Genetic studies revealed that Abl family kinases interact functionally with microtubules, but the mechanism by which Abl kinases regulate microtubules remains unclear. Hu et al. provide the first evidence that the Abl family kinase Abl2 directly binds microtubules to regulate microtubule dynamics.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"218 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130727306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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