Pub Date : 2024-01-01Epub Date: 2024-12-04DOI: 10.15388/Amed.2024.31.2.24
Saifullah Khalid, Manzoor Ahmad, Ezaz Ahmed, Wasif Mohammad, AliImad Ali
Background: Renal vascular injuries, like renal artery pseudoaneurysms and arteriovenous fistulas, are rare but serious complications following renal procedures and trauma. Standard management requires costly microcatheters for angioembolization. This study investigates a cost-effective method using diagnostic catheters and affordable coils in a low-resource setting.
Methods: We analyzed five patients from December 2023 to June 2024 who had persistent hematuria or hemoglobin drops after renal intervention or trauma. CT angiography identified their injuries, and angioembolization was performed with diagnostic catheters and coils, reducing procedural costs.
Results: The use of diagnostic catheters and coils successfully managed all cases. Patients experienced resolution of hematuria and were discharged in 2-3 days. Follow-up over three months revealed no recurrence or significant renal function issues.
Conclusion: Diagnostic catheters and coils offer an effective method for managing renal vascular injuries in resource-limited settings, achieving satisfactory outcomes with minimal morbidity.
{"title":"figManagement of Renal Vascular Injuries by Angioembolization in a Low Resource Setting: A Case Series with Review of Literature.","authors":"Saifullah Khalid, Manzoor Ahmad, Ezaz Ahmed, Wasif Mohammad, AliImad Ali","doi":"10.15388/Amed.2024.31.2.24","DOIUrl":"10.15388/Amed.2024.31.2.24","url":null,"abstract":"<p><strong>Background: </strong>Renal vascular injuries, like renal artery pseudoaneurysms and arteriovenous fistulas, are rare but serious complications following renal procedures and trauma. Standard management requires costly microcatheters for angioembolization. This study investigates a cost-effective method using diagnostic catheters and affordable coils in a low-resource setting.</p><p><strong>Methods: </strong>We analyzed five patients from December 2023 to June 2024 who had persistent hematuria or hemoglobin drops after renal intervention or trauma. CT angiography identified their injuries, and angioembolization was performed with diagnostic catheters and coils, reducing procedural costs.</p><p><strong>Results: </strong>The use of diagnostic catheters and coils successfully managed all cases. Patients experienced resolution of hematuria and were discharged in 2-3 days. Follow-up over three months revealed no recurrence or significant renal function issues.</p><p><strong>Conclusion: </strong>Diagnostic catheters and coils offer an effective method for managing renal vascular injuries in resource-limited settings, achieving satisfactory outcomes with minimal morbidity.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"416-422"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-12-04DOI: 10.15388/Amed.2024.31.2.7
Sigita Lesinskienė, Mariam Afrahi, Kamilė Pociūtė
Background: Nonsuicidal self-injurious behavior in children and adolescents is a major concern that requires mental health professionals' attention. The aim of this study is to analyze clinical care aspects of children and adolescents who self-harm in psychiatric hospitals.
Materials and methods: In 2023, 30 various specialists from five different child and adolescent psychiatric units in Lithuania were interviewed. The survey used a semistructured interview consisting of twelve questions related to complex clinical care methods of children and adolescents who self-harm. The interview responses were summarized and grouped into 5 categories: assessment and monitoring, methods and consequences of self-injury, safety measures, prevention and treatment, insights from staff.
Results: Self-injurious behavior in psychiatric inpatient settings was managed through risk assessment, monitoring, communication, medication, counselling, removal of sharp objects, patient allocation, and a several of other methods such as safety contracts, rewards or alternate pain-inducing or self-harm mimicking stimuli. Despite the hospital's safety procedures patients frequently devised alternate methods to self-harm, such as hitting and scratching themselves and using nonspecific materials.
Conclusions: The management of self-harm in children and adolescents psychiatric settings remains insufficient. Further research is needed to explore alternative ways of managing self-injurious behavior in child and adolescent psychiatric hospitals.
{"title":"Self-Injurious Behavior in Child and Adolescent Psychiatry Inpatient Units: Actual Aspects of the Complex Care Provision.","authors":"Sigita Lesinskienė, Mariam Afrahi, Kamilė Pociūtė","doi":"10.15388/Amed.2024.31.2.7","DOIUrl":"10.15388/Amed.2024.31.2.7","url":null,"abstract":"<p><strong>Background: </strong>Nonsuicidal self-injurious behavior in children and adolescents is a major concern that requires mental health professionals' attention. The aim of this study is to analyze clinical care aspects of children and adolescents who self-harm in psychiatric hospitals.</p><p><strong>Materials and methods: </strong>In 2023, 30 various specialists from five different child and adolescent psychiatric units in Lithuania were interviewed. The survey used a semistructured interview consisting of twelve questions related to complex clinical care methods of children and adolescents who self-harm. The interview responses were summarized and grouped into 5 categories: assessment and monitoring, methods and consequences of self-injury, safety measures, prevention and treatment, insights from staff.</p><p><strong>Results: </strong>Self-injurious behavior in psychiatric inpatient settings was managed through risk assessment, monitoring, communication, medication, counselling, removal of sharp objects, patient allocation, and a several of other methods such as safety contracts, rewards or alternate pain-inducing or self-harm mimicking stimuli. Despite the hospital's safety procedures patients frequently devised alternate methods to self-harm, such as hitting and scratching themselves and using nonspecific materials.</p><p><strong>Conclusions: </strong>The management of self-harm in children and adolescents psychiatric settings remains insufficient. Further research is needed to explore alternative ways of managing self-injurious behavior in child and adolescent psychiatric hospitals.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"275-287"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-12-04DOI: 10.15388/Amed.2024.31.2.2
Saphal Lakshmi Pasupulati, Sanjit Satheesan, Piyush Saiyam, Saketh Chowdary, P K Sankaran, Kishore Sesham
During the routine dissection of lower limb in a female cadaver of age 61 years, a rare variation in the extensor digitorum longus (EDL) muscle was noticed on the both legs. An EDL muscle with small belly dividing into two slips, which inserted on to the second and third digits on the right leg, whereas on the left leg divided into three slips, which inserted on to the second, third and fourth digits. There was also an accessory EDL muscle arising from the middle third of the medial surface of the fibula and inserted on to the fifth digit in the left foot, and it inserted on to the fourth and fifth digits in the right foot. To our knowledge, such variation hasn't been reported in literature and apprehension of such variations is important for surgeons and orthopaedicians with regards to contractures and surgical procedures concerning the anterior leg and dorsum of the foot.
{"title":"An Accessory Extensor Digitorum Longus Muscle - a Rare Variation.","authors":"Saphal Lakshmi Pasupulati, Sanjit Satheesan, Piyush Saiyam, Saketh Chowdary, P K Sankaran, Kishore Sesham","doi":"10.15388/Amed.2024.31.2.2","DOIUrl":"10.15388/Amed.2024.31.2.2","url":null,"abstract":"<p><p>During the routine dissection of lower limb in a female cadaver of age 61 years, a rare variation in the extensor digitorum longus (EDL) muscle was noticed on the both legs. An EDL muscle with small belly dividing into two slips, which inserted on to the second and third digits on the right leg, whereas on the left leg divided into three slips, which inserted on to the second, third and fourth digits. There was also an accessory EDL muscle arising from the middle third of the medial surface of the fibula and inserted on to the fifth digit in the left foot, and it inserted on to the fourth and fifth digits in the right foot. To our knowledge, such variation hasn't been reported in literature and apprehension of such variations is important for surgeons and orthopaedicians with regards to contractures and surgical procedures concerning the anterior leg and dorsum of the foot.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"334-338"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-12-04DOI: 10.15388/Amed.2024.31.2.13
Edoardo Ipponi, Martina Cordoni, Elena Bechini, Fabrizia Gentili, Fabio Cosseddu, Antonio D'Arienzo, Lorenzo Andreani
Background: The distal tibia is one of the rarest sites for the onset of malignant and locally aggressive bone tumors. When diagnosed, these lesions should undergo surgical resection with wide margins to eradicate the disease. In the era of limb-sparing surgery, several reconstructive approaches have been proposed and described in modern literature for reconstructing the distal tibia and the ankle. The 3D-printed custom-made prostheses represent an innovative and promising reconstructive option. Several authors highlighted that despite being expensive and prone to some complications such as talar collapse or loosening and soft tissue necrosis, the megaprostheses of the distal tibia could lead to good functional outcomes, also allowing a better range of motion compared to the most common arthrodesis.
Materials and methods: We report two cases who suffered from malignant bone tumors localized in the distal tibia and treated with wide resections and the implant of 3D printed custom-made megaprostheses to replace the distal tibia and the ankle.
Results: Both patients had excellent functional results (MSTS 30/30) one year after surgery. No local recurrence occurred during the patients' latest follow-up.
Conclusions: Our results support the effectiveness of custom-made implants in replacing the distal tibia and the ankle in orthopedic oncology.
{"title":"Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature.","authors":"Edoardo Ipponi, Martina Cordoni, Elena Bechini, Fabrizia Gentili, Fabio Cosseddu, Antonio D'Arienzo, Lorenzo Andreani","doi":"10.15388/Amed.2024.31.2.13","DOIUrl":"10.15388/Amed.2024.31.2.13","url":null,"abstract":"<p><strong>Background: </strong>The distal tibia is one of the rarest sites for the onset of malignant and locally aggressive bone tumors. When diagnosed, these lesions should undergo surgical resection with wide margins to eradicate the disease. In the era of limb-sparing surgery, several reconstructive approaches have been proposed and described in modern literature for reconstructing the distal tibia and the ankle. The 3D-printed custom-made prostheses represent an innovative and promising reconstructive option. Several authors highlighted that despite being expensive and prone to some complications such as talar collapse or loosening and soft tissue necrosis, the megaprostheses of the distal tibia could lead to good functional outcomes, also allowing a better range of motion compared to the most common arthrodesis.</p><p><strong>Materials and methods: </strong>We report two cases who suffered from malignant bone tumors localized in the distal tibia and treated with wide resections and the implant of 3D printed custom-made megaprostheses to replace the distal tibia and the ankle.</p><p><strong>Results: </strong>Both patients had excellent functional results (MSTS 30/30) one year after surgery. No local recurrence occurred during the patients' latest follow-up.</p><p><strong>Conclusions: </strong>Our results support the effectiveness of custom-made implants in replacing the distal tibia and the ankle in orthopedic oncology.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"372-381"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-12-04DOI: 10.15388/Amed.2024.31.2.19
Fatma Çelik, Aylin Ayyıldız, Selda Çiftci İnceoğlu, Figen Yılmaz, Mustafa Çelik, Banu Kuran
Background: The objective of this study is to assess the clinical and electrophysiological effectiveness of electrical stimulation in patients diagnosed Bell's palsy (BP), and to examine its impact on potential complications that may arise during the course of the illness.
Methods: Thirty patients diagnosed with BP were enrolled and randomized into two treatment groups of 15 patients each. The treatment group (TG) received 15 sessions of electrical stimulation (ES), infrared, and exercise therapy, 5 days a week for 3 weeks, while the control group (CG) received sham ES, infrared, and exercise therapy. Evaluations were conducted by electromyography before treatment and at 1 and 3 months after the end of treatment for all patients.
Results: When evaluating patients in both groups based on the side where the BP developed, electrophysiological examination showed an increase in the rate of synkinesis in both the TG and CG. However, there was no statistically significant difference between the two groups. The study found that ES did not reduce the presence of synkinesis in denervated muscles. However, the nerve conduction studies of the studied branches of the facial nerve showed a decrease in distal latencies and an increase in amplitudes of compound muscle action potentials, indicating that ES has a positive effect on nerve regeneration.
Conclusion: ES resulted in a notable reduction in distal latency values within the treatment group. Additionally, ES was found to significantly alleviate depressive symptoms, although it did not result in an improvement in overall quality of life. Therefore, ES is considered a safe treatment method that can be used in the treatment of BP.
{"title":"Clinical and Electrophysiological Evaluation of Electrical Stimulation in Patients with Bell's Palsy.","authors":"Fatma Çelik, Aylin Ayyıldız, Selda Çiftci İnceoğlu, Figen Yılmaz, Mustafa Çelik, Banu Kuran","doi":"10.15388/Amed.2024.31.2.19","DOIUrl":"10.15388/Amed.2024.31.2.19","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to assess the clinical and electrophysiological effectiveness of electrical stimulation in patients diagnosed Bell's palsy (BP), and to examine its impact on potential complications that may arise during the course of the illness.</p><p><strong>Methods: </strong>Thirty patients diagnosed with BP were enrolled and randomized into two treatment groups of 15 patients each. The treatment group (TG) received 15 sessions of electrical stimulation (ES), infrared, and exercise therapy, 5 days a week for 3 weeks, while the control group (CG) received sham ES, infrared, and exercise therapy. Evaluations were conducted by electromyography before treatment and at 1 and 3 months after the end of treatment for all patients.</p><p><strong>Results: </strong>When evaluating patients in both groups based on the side where the BP developed, electrophysiological examination showed an increase in the rate of synkinesis in both the TG and CG. However, there was no statistically significant difference between the two groups. The study found that ES did not reduce the presence of synkinesis in denervated muscles. However, the nerve conduction studies of the studied branches of the facial nerve showed a decrease in distal latencies and an increase in amplitudes of compound muscle action potentials, indicating that ES has a positive effect on nerve regeneration.</p><p><strong>Conclusion: </strong>ES resulted in a notable reduction in distal latency values within the treatment group. Additionally, ES was found to significantly alleviate depressive symptoms, although it did not result in an improvement in overall quality of life. Therefore, ES is considered a safe treatment method that can be used in the treatment of BP.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"31 2","pages":"302-314"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-22DOI: 10.15388/amed.2023.30.2.15
P. Virych, N. Shuvalova, Anton F. Karas, Galina Karas, Svitlana Chaika, T. Kucherenko, Ganna Y. Minina, Marina Timchenko, Oleg Melnykov, Yurii Minin
Background. The restoration of auricular cartilage is a major problem of otolaryngology. The low regenerative capacity of cartilage requires alternative approaches such as cell and tissue engineering. Stem cells are one of the ways to repair auricular cartilage damages. The aim of the investigation was the regeneration of an artificial defect of the auricular cartilage of rabbits after the intravenous injection of stem cells.Materials and Methods. The study was carried out on rabbits. A narrow strip of auricular cartilage was surgically removed. A previously prepared suspension of homologous mesenchymal stem cells (5 million) in 0.5 ml physiological solution was injected into the vein of the opposite ear. Tissue samples from the site of the injury were collected after 1, 2, and 3 months. Histological examinations of the tissues were carried out after staining with fuchsin-eosin, azure II–eosin, and according to Weigert. In addition, the amount of interleukin-6 (IL-6) and the transforming growth factor β1 (TGF-β1) in the blood serum were determined.Results. The main method of healing is the formation of a connective tissue scar. Yret, an increase of the number of fibroblasts and single islands of the newly formed auricular cartilage was found, which indicates the migration of the injected stem cells to the site of the damage and settling there. The intravenous injection of stem cells did not affect the secretion of pro-inflammatory IL-6, but significantly increased the amount of TGF-β1.Conclusions. We assume that regenerative processes were stimulated. Nevertheless, they were aimed at quickly restoring the tissue integrity through the typical stages of scar formation. The restoration of cartilage integrity requires additional regulatory factors which will determine the chondrogenic differentiation of stem cells.
{"title":"Regeneration of Rabbit Auricular Cartilage After the Intravenous Stem Cell Injection","authors":"P. Virych, N. Shuvalova, Anton F. Karas, Galina Karas, Svitlana Chaika, T. Kucherenko, Ganna Y. Minina, Marina Timchenko, Oleg Melnykov, Yurii Minin","doi":"10.15388/amed.2023.30.2.15","DOIUrl":"https://doi.org/10.15388/amed.2023.30.2.15","url":null,"abstract":"Background. The restoration of auricular cartilage is a major problem of otolaryngology. The low regenerative capacity of cartilage requires alternative approaches such as cell and tissue engineering. Stem cells are one of the ways to repair auricular cartilage damages. The aim of the investigation was the regeneration of an artificial defect of the auricular cartilage of rabbits after the intravenous injection of stem cells.Materials and Methods. The study was carried out on rabbits. A narrow strip of auricular cartilage was surgically removed. A previously prepared suspension of homologous mesenchymal stem cells (5 million) in 0.5 ml physiological solution was injected into the vein of the opposite ear. Tissue samples from the site of the injury were collected after 1, 2, and 3 months. Histological examinations of the tissues were carried out after staining with fuchsin-eosin, azure II–eosin, and according to Weigert. In addition, the amount of interleukin-6 (IL-6) and the transforming growth factor β1 (TGF-β1) in the blood serum were determined.Results. The main method of healing is the formation of a connective tissue scar. Yret, an increase of the number of fibroblasts and single islands of the newly formed auricular cartilage was found, which indicates the migration of the injected stem cells to the site of the damage and settling there. The intravenous injection of stem cells did not affect the secretion of pro-inflammatory IL-6, but significantly increased the amount of TGF-β1.Conclusions. We assume that regenerative processes were stimulated. Nevertheless, they were aimed at quickly restoring the tissue integrity through the typical stages of scar formation. The restoration of cartilage integrity requires additional regulatory factors which will determine the chondrogenic differentiation of stem cells.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"99 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.15388/amed.2023.30.2.14
Agnė Okulevičiūtė, Gabija Laubner Sakalauskienė
Introduction: Benzodiazepines are commonly prescribed but often misused, leading to dependence and withdrawal symptoms. Increased worldwide prescriptions raise adverse effects and overdose concerns, especially for the elderly. Caution is needed in prescribing and considering alternative treatments to minimize risks. Aim: Narrative literature review of potential atrial fibrillation mechanism of action induced by discontinuation of benzodiazepines. Materials and methods: Database PubMed was searched using the combination of keywords – “Benzodiazepine AND atrial fibrillation OR peripheral benzodiazepine receptors”, “history of benzodiazepines”, “benzodiazepines mechanism of action”, “benzodiazepines indications”, “benzodiazepines adverse effects” and “benzodiazepines withdrawal effects”. Non-full-text and non-English scientific publications were removed. A total of 31 publication was included. Discussion: Benzodiazepines (BZDs) were synthesized in 1955 and initially considered less toxic than barbiturates. They interact with GABA-A receptors, causing hyperpolarization and inhibitory effects in the central nervous system. BZDs are used to treat various clinical disorders, but long-term use can lead to adverse effects and withdrawal symptoms. There is evidence that genetic diversity can influence the response to BZDs through GABA receptors. The interaction between benzodiazepines and peripheral benzodiazepine receptors may influence calcium ion channels, affecting cardiac action potential and contractility, and discontinuation of these medications can potentially contribute to atrial fibrillation. Additionally, benzodiazepines may directly affect calcium channels, causing antiarrhythmic effects and vasodilation. Conclusion: In summary, benzodiazepines, once considered safer sedatives, now raise concerns about misuse, dependence, and withdrawal symptoms. While there is a potential link between discontinuing benzodiazepines and atrial fibrillation through mechanisms involving peripheral benzodiazepine receptors and cardiac calcium channels, causality remains uncertain and multifaceted. Further research is needed to clarify these mechanisms, and healthcare providers should exercise caution in long-term benzodiazepine prescriptions while exploring alternative treatment strategies to mitigate risks.
{"title":"Narrative Literature Review of Potential Atrial Fibrillation Mechanism of Action Induced by Discontinuation of Benzodiazepines","authors":"Agnė Okulevičiūtė, Gabija Laubner Sakalauskienė","doi":"10.15388/amed.2023.30.2.14","DOIUrl":"https://doi.org/10.15388/amed.2023.30.2.14","url":null,"abstract":"Introduction: Benzodiazepines are commonly prescribed but often misused, leading to dependence and withdrawal symptoms. Increased worldwide prescriptions raise adverse effects and overdose concerns, especially for the elderly. Caution is needed in prescribing and considering alternative treatments to minimize risks. Aim: Narrative literature review of potential atrial fibrillation mechanism of action induced by discontinuation of benzodiazepines. Materials and methods: Database PubMed was searched using the combination of keywords – “Benzodiazepine AND atrial fibrillation OR peripheral benzodiazepine receptors”, “history of benzodiazepines”, “benzodiazepines mechanism of action”, “benzodiazepines indications”, “benzodiazepines adverse effects” and “benzodiazepines withdrawal effects”. Non-full-text and non-English scientific publications were removed. A total of 31 publication was included. Discussion: Benzodiazepines (BZDs) were synthesized in 1955 and initially considered less toxic than barbiturates. They interact with GABA-A receptors, causing hyperpolarization and inhibitory effects in the central nervous system. BZDs are used to treat various clinical disorders, but long-term use can lead to adverse effects and withdrawal symptoms. There is evidence that genetic diversity can influence the response to BZDs through GABA receptors. The interaction between benzodiazepines and peripheral benzodiazepine receptors may influence calcium ion channels, affecting cardiac action potential and contractility, and discontinuation of these medications can potentially contribute to atrial fibrillation. Additionally, benzodiazepines may directly affect calcium channels, causing antiarrhythmic effects and vasodilation. Conclusion: In summary, benzodiazepines, once considered safer sedatives, now raise concerns about misuse, dependence, and withdrawal symptoms. While there is a potential link between discontinuing benzodiazepines and atrial fibrillation through mechanisms involving peripheral benzodiazepine receptors and cardiac calcium channels, causality remains uncertain and multifaceted. Further research is needed to clarify these mechanisms, and healthcare providers should exercise caution in long-term benzodiazepine prescriptions while exploring alternative treatment strategies to mitigate risks.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"14 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139274589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.15388/amed.2023.30.2.13
Anna Kornete, D. Bokučava, Natalija Vedmedovska
Sacrococcygeal teratoma (SCT) occurs in approximately 1 per 20,000–40,000 births and is the most frequently encountered fetal teratoma, with 75% of cases observed in female fetuses. SCT can be detected on ultrasound as early as the first trimester, presenting as a large mass originating from the sacrococcygeal area, with or without an intrapelvic component. The prenatal course for most fetuses with SCT is generally uneventful, with only a few cases experiencing obstetric and fetal complications. We present the case of a 19-year-old woman who was in good health and had no relevant family or medical history. She was gravida 2 and para 1. During the first trimester scan, an examination revealed a heterogeneous mass in the presacral area with a predominantly multicystic appearance, measuring 12 mm in diameter. At 21+6 weeks of gestation, the Type 2 fetal SCT showed an increase in volume with the size of 49×37×36 mm and contiune to increase in size. The male fetus was delivered by elective Cesarean section at 38 weeks of gestation. The resection of the tumor and coccyx was performed when the newborn was 7 days old. The tumor measured 190×160×100 mm and weighed 1100 g. Pathological examination confirmed the diagnosis of a mature teratoma (Grade 0), and the resection margins were negative. Our case report highlights a fetus with a large and rapidly growing SCT, yet the outcome was excellent.
{"title":"Fetal Sacrococcygeal Teratoma: A Case Report of a Giant Tumor with an Excellent Outcome","authors":"Anna Kornete, D. Bokučava, Natalija Vedmedovska","doi":"10.15388/amed.2023.30.2.13","DOIUrl":"https://doi.org/10.15388/amed.2023.30.2.13","url":null,"abstract":"Sacrococcygeal teratoma (SCT) occurs in approximately 1 per 20,000–40,000 births and is the most frequently encountered fetal teratoma, with 75% of cases observed in female fetuses. SCT can be detected on ultrasound as early as the first trimester, presenting as a large mass originating from the sacrococcygeal area, with or without an intrapelvic component. The prenatal course for most fetuses with SCT is generally uneventful, with only a few cases experiencing obstetric and fetal complications. We present the case of a 19-year-old woman who was in good health and had no relevant family or medical history. She was gravida 2 and para 1. During the first trimester scan, an examination revealed a heterogeneous mass in the presacral area with a predominantly multicystic appearance, measuring 12 mm in diameter. At 21+6 weeks of gestation, the Type 2 fetal SCT showed an increase in volume with the size of 49×37×36 mm and contiune to increase in size. The male fetus was delivered by elective Cesarean section at 38 weeks of gestation. The resection of the tumor and coccyx was performed when the newborn was 7 days old. The tumor measured 190×160×100 mm and weighed 1100 g. Pathological examination confirmed the diagnosis of a mature teratoma (Grade 0), and the resection margins were negative. Our case report highlights a fetus with a large and rapidly growing SCT, yet the outcome was excellent.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"23 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139274846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.15388/amed.2023.30.2.12
Gurpreet Kaur, R. Lalwani, Manal M. Khan, Sunita A Athavale
Background. Architectural properties of the muscles are the prime predictors of functional attributes and force-generating capacity of the muscles. This data is vital for musculoskeletal modelling and selecting the appropriate muscle–tendon units for tendon transfers.Cadaveric data for architectural properties is the gold standard and primary input for musculoskeletal modelling. There is a paucity of these datasets, especially in the leg muscles.Methods. Sixty muscles of the anterior and lateral compartments from twelve formalin-fixed lower limbs were studied for gross architecture, including the peculiar fibre arrangements and architectural properties of muscles. Muscle weight, muscle length, fibre length, pennation angle and sarcomere length were measured. Normalised fibre length, fibre length to muscle length ratio (FL/ML ratio), and the physiological cross-sectional area (PCSA) were calculated from the obtained data.Results. Muscles displayed a combination of architectural strategies and were partly fusiform and partly pennate. The tibialis anterior and peroneus longus were the heaviest muscles in their respective compartments and showed more extensive origin from the nearby deep facial sheets.Long fibre length and less pennation angle were seen in muscles of the extensor compartment. Potential muscle power was highest in the tibialis anterior and peroneus longus and least in the extensor hallucis longus.Conclusions. Arching of the foot and eversion are peculiar to humans and recent in evolution. Due to the functional demand of maintaining the medial longitudinal arch and eversion, the tibialis anterior and peroneus longus have more muscle weight and larger physiological cross-sectional area and are potentially more powerful.Extensor compartment muscles were architecturally more suited for excursions because of the long fibre length and less pennation angle.This study contributes baseline normative data for musculoskeletal modelling platforms and simulation tools – an emerging area in biomechanics and tendon transfers.
{"title":"Muscle Architecture of Leg Muscles: Functional and Clinical Significance","authors":"Gurpreet Kaur, R. Lalwani, Manal M. Khan, Sunita A Athavale","doi":"10.15388/amed.2023.30.2.12","DOIUrl":"https://doi.org/10.15388/amed.2023.30.2.12","url":null,"abstract":"Background. Architectural properties of the muscles are the prime predictors of functional attributes and force-generating capacity of the muscles. This data is vital for musculoskeletal modelling and selecting the appropriate muscle–tendon units for tendon transfers.Cadaveric data for architectural properties is the gold standard and primary input for musculoskeletal modelling. There is a paucity of these datasets, especially in the leg muscles.Methods. Sixty muscles of the anterior and lateral compartments from twelve formalin-fixed lower limbs were studied for gross architecture, including the peculiar fibre arrangements and architectural properties of muscles. Muscle weight, muscle length, fibre length, pennation angle and sarcomere length were measured. Normalised fibre length, fibre length to muscle length ratio (FL/ML ratio), and the physiological cross-sectional area (PCSA) were calculated from the obtained data.Results. Muscles displayed a combination of architectural strategies and were partly fusiform and partly pennate. The tibialis anterior and peroneus longus were the heaviest muscles in their respective compartments and showed more extensive origin from the nearby deep facial sheets.Long fibre length and less pennation angle were seen in muscles of the extensor compartment. Potential muscle power was highest in the tibialis anterior and peroneus longus and least in the extensor hallucis longus.Conclusions. Arching of the foot and eversion are peculiar to humans and recent in evolution. Due to the functional demand of maintaining the medial longitudinal arch and eversion, the tibialis anterior and peroneus longus have more muscle weight and larger physiological cross-sectional area and are potentially more powerful.Extensor compartment muscles were architecturally more suited for excursions because of the long fibre length and less pennation angle.This study contributes baseline normative data for musculoskeletal modelling platforms and simulation tools – an emerging area in biomechanics and tendon transfers.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"88 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-18DOI: 10.15388/amed.2023.30.2.6
Petros Galanis, Aglaia Katsiroumpa, Irene Vraka, Katerina Kosiara, Olga Siskou, Olympia Konstantakopoulou, Theodoros Katsoulas, Parisis Gallos, Daphne Kaitelidou
Background: Post-COVID-19 syndrome affects a significant number of SARS-CoV-2 infected individuals, even in asymptomatic cases causing several neurological and neuropsychiatric symptoms and signs.Materials and Methods: An online cross-sectional study with a convenience sample was conducted in Greece from November 2022 to January 2023. We measured the demographic and clinical characteristics of patients with post-COVID-19 dysautonomia in terms of the quality of life with the EQ-5D-3L, and anxiety and depressive symptoms by employing Patient Health Questionnaire-4.Results: The study population included 122 patients with post-COVID-19 syndrome. One out of four patients (27.8%) manifested post-COVID-19 dysautonomia, while the mean duration of COVID-19 symptoms was 11.6 months. Anxiety and depressive symptoms were worse after the post-COVID-19 syndrome (p<0.001 in both cases). A statistically significant reduction in quality of life was observed among patients after the post-COVID-19 syndrome (p<0.001 for both EQ-5D-3L index value and EQ-5D-3L VAS). Post-COVID-19 dysautonomia increased depression symptoms after developing the post-COVID-19 syndrome (p=0.02). We found a negative relationship between the duration of COVID-19 symptoms and the quality of life (p<0.001). Moreover, our results showed that depressive symptoms were more common among females after the post-COVID-19 syndrome (p=0.01). Also, the quality of life was lower among females than males (p=0.004 for EQ-5D-3L index value, and p=0.007 for EQ-5D-3L VAS).Conclusions: Our results suggest that post-COVID-19 syndrome causes a tremendous impact on the patients’ quality of life and mental health. In addition, we found that the groups most psychologically affected were patients with post-COVID-19 dysautonomia, females, and patients with a longer duration of symptoms. Policy makers should assign priority rights to vulnerable groups in future psychiatric planning. Policy measures should focus on the mental health of post-COVID-19 patients who seem to be particularly vulnerable.
背景:covid -19后综合征影响大量SARS-CoV-2感染者,即使在无症状病例中也会引起几种神经和神经精神症状和体征。材料和方法:从2022年11月到2023年1月,在希腊进行了一项方便样本的在线横断面研究。我们采用《患者健康问卷-4》(Patient Health Questionnaire-4)测量了covid -19后自主神经异常患者的人口学特征和临床特征,包括EQ-5D-3L的生活质量以及焦虑和抑郁症状。结果:研究人群包括122例covid -19后综合征患者。1 / 4的患者(27.8%)出现新型冠状病毒感染后自主神经异常,平均持续时间为11.6个月。焦虑和抑郁症状在covid -19综合征后加重(p<0.001)。covid -19综合征后患者的生活质量下降具有统计学意义(EQ-5D-3L指数值和EQ-5D-3L VAS的p<均为0.001)。出现covid -19后综合征后,自主神经异常加重了抑郁症状(p=0.02)。我们发现COVID-19症状持续时间与生活质量呈负相关(p<0.001)。此外,我们的研究结果显示,女性在covid -19综合征后出现抑郁症状更为常见(p=0.01)。此外,女性的生活质量低于男性(EQ-5D-3L指数值p=0.004, EQ-5D-3L VAS p=0.007)。结论:我们的研究结果表明,covid -19后综合征对患者的生活质量和心理健康造成了巨大的影响。此外,我们发现心理上受影响最大的群体是covid -19后自主神经紊乱患者、女性和症状持续时间较长的患者。在未来的精神病学规划中,决策者应优先考虑弱势群体。政策措施应侧重于似乎特别脆弱的covid -19后患者的心理健康。
{"title":"Post-COVID-19 Syndrome and Related Dysautonomia: Reduced Quality of Life, Increased Anxiety and Manifestation of Depressive Symptoms: Evidence from Greece","authors":"Petros Galanis, Aglaia Katsiroumpa, Irene Vraka, Katerina Kosiara, Olga Siskou, Olympia Konstantakopoulou, Theodoros Katsoulas, Parisis Gallos, Daphne Kaitelidou","doi":"10.15388/amed.2023.30.2.6","DOIUrl":"https://doi.org/10.15388/amed.2023.30.2.6","url":null,"abstract":"Background: Post-COVID-19 syndrome affects a significant number of SARS-CoV-2 infected individuals, even in asymptomatic cases causing several neurological and neuropsychiatric symptoms and signs.Materials and Methods: An online cross-sectional study with a convenience sample was conducted in Greece from November 2022 to January 2023. We measured the demographic and clinical characteristics of patients with post-COVID-19 dysautonomia in terms of the quality of life with the EQ-5D-3L, and anxiety and depressive symptoms by employing Patient Health Questionnaire-4.Results: The study population included 122 patients with post-COVID-19 syndrome. One out of four patients (27.8%) manifested post-COVID-19 dysautonomia, while the mean duration of COVID-19 symptoms was 11.6 months. Anxiety and depressive symptoms were worse after the post-COVID-19 syndrome (p<0.001 in both cases). A statistically significant reduction in quality of life was observed among patients after the post-COVID-19 syndrome (p<0.001 for both EQ-5D-3L index value and EQ-5D-3L VAS). Post-COVID-19 dysautonomia increased depression symptoms after developing the post-COVID-19 syndrome (p=0.02). We found a negative relationship between the duration of COVID-19 symptoms and the quality of life (p<0.001). Moreover, our results showed that depressive symptoms were more common among females after the post-COVID-19 syndrome (p=0.01). Also, the quality of life was lower among females than males (p=0.004 for EQ-5D-3L index value, and p=0.007 for EQ-5D-3L VAS).Conclusions: Our results suggest that post-COVID-19 syndrome causes a tremendous impact on the patients’ quality of life and mental health. In addition, we found that the groups most psychologically affected were patients with post-COVID-19 dysautonomia, females, and patients with a longer duration of symptoms. Policy makers should assign priority rights to vulnerable groups in future psychiatric planning. Policy measures should focus on the mental health of post-COVID-19 patients who seem to be particularly vulnerable.","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135824403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}