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figManagement of Renal Vascular Injuries by Angioembolization in a Low Resource Setting: A Case Series with Review of Literature. 图低资源环境下血管栓塞治疗肾血管损伤:一个病例系列并文献回顾。
Q3 Medicine Pub Date : 2024-01-01 Epub Date: 2024-12-04 DOI: 10.15388/Amed.2024.31.2.24
Saifullah Khalid, Manzoor Ahmad, Ezaz Ahmed, Wasif Mohammad, AliImad Ali

Background: Renal vascular injuries, like renal artery pseudoaneurysms and arteriovenous fistulas, are rare but serious complications following renal procedures and trauma. Standard management requires costly microcatheters for angioembolization. This study investigates a cost-effective method using diagnostic catheters and affordable coils in a low-resource setting.

Methods: We analyzed five patients from December 2023 to June 2024 who had persistent hematuria or hemoglobin drops after renal intervention or trauma. CT angiography identified their injuries, and angioembolization was performed with diagnostic catheters and coils, reducing procedural costs.

Results: The use of diagnostic catheters and coils successfully managed all cases. Patients experienced resolution of hematuria and were discharged in 2-3 days. Follow-up over three months revealed no recurrence or significant renal function issues.

Conclusion: Diagnostic catheters and coils offer an effective method for managing renal vascular injuries in resource-limited settings, achieving satisfactory outcomes with minimal morbidity.

背景:肾血管损伤,如肾动脉假性动脉瘤和动静脉瘘,是肾脏手术和创伤后罕见但严重的并发症。标准管理需要昂贵的微导管进行血管栓塞。本研究探讨了在低资源环境下使用诊断导管和负担得起的线圈的成本效益方法。方法:对2023年12月至2024年6月5例肾脏干预或外伤后持续血尿或血红蛋白下降的患者进行分析。CT血管造影确定了他们的损伤,并使用诊断导管和线圈进行血管栓塞,降低了手术成本。结果:所有病例均成功应用诊断导管和线圈。患者血尿消退,2 ~ 3天出院。随访3个多月,未发现复发或明显的肾功能问题。结论:在资源有限的情况下,诊断性导管和线圈是治疗肾血管损伤的有效方法,以最小的发病率获得满意的结果。
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引用次数: 0
Self-Injurious Behavior in Child and Adolescent Psychiatry Inpatient Units: Actual Aspects of the Complex Care Provision. 儿童和青少年精神病学住院病房的自伤行为:复杂护理提供的实际方面。
Q3 Medicine Pub Date : 2024-01-01 Epub Date: 2024-12-04 DOI: 10.15388/Amed.2024.31.2.7
Sigita Lesinskienė, Mariam Afrahi, Kamilė Pociūtė

Background: Nonsuicidal self-injurious behavior in children and adolescents is a major concern that requires mental health professionals' attention. The aim of this study is to analyze clinical care aspects of children and adolescents who self-harm in psychiatric hospitals.

Materials and methods: In 2023, 30 various specialists from five different child and adolescent psychiatric units in Lithuania were interviewed. The survey used a semistructured interview consisting of twelve questions related to complex clinical care methods of children and adolescents who self-harm. The interview responses were summarized and grouped into 5 categories: assessment and monitoring, methods and consequences of self-injury, safety measures, prevention and treatment, insights from staff.

Results: Self-injurious behavior in psychiatric inpatient settings was managed through risk assessment, monitoring, communication, medication, counselling, removal of sharp objects, patient allocation, and a several of other methods such as safety contracts, rewards or alternate pain-inducing or self-harm mimicking stimuli. Despite the hospital's safety procedures patients frequently devised alternate methods to self-harm, such as hitting and scratching themselves and using nonspecific materials.

Conclusions: The management of self-harm in children and adolescents psychiatric settings remains insufficient. Further research is needed to explore alternative ways of managing self-injurious behavior in child and adolescent psychiatric hospitals.

背景:儿童和青少年的非自杀性自伤行为是一个需要心理健康专业人员关注的主要问题。本研究的目的是分析在精神病院自残的儿童和青少年的临床护理方面。材料和方法:2023年,采访了来自立陶宛五个不同儿童和青少年精神科的30名不同专家。调查采用半结构化访谈,包括12个问题,涉及儿童和青少年自残的复杂临床护理方法。访谈结果汇总并分为5类:评估与监测、自伤方法与后果、安全措施、预防与治疗、员工见解。结果:通过风险评估、监测、沟通、药物治疗、咨询、移除尖锐物品、患者分配以及安全合同、奖励或替代诱导疼痛或模仿自残刺激等几种其他方法来管理精神科住院患者的自伤行为。尽管医院有安全程序,但病人经常想出其他自残方法,比如打自己、抓自己,以及使用非特异性材料。结论:在儿童和青少年精神病院自我伤害的管理仍然不足。需要进一步的研究来探索在儿童和青少年精神病院管理自伤行为的替代方法。
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引用次数: 0
An Accessory Extensor Digitorum Longus Muscle - a Rare Variation. 指长副伸肌-一种罕见的变异。
Q3 Medicine Pub Date : 2024-01-01 Epub Date: 2024-12-04 DOI: 10.15388/Amed.2024.31.2.2
Saphal Lakshmi Pasupulati, Sanjit Satheesan, Piyush Saiyam, Saketh Chowdary, P K Sankaran, Kishore Sesham

During the routine dissection of lower limb in a female cadaver of age 61 years, a rare variation in the extensor digitorum longus (EDL) muscle was noticed on the both legs. An EDL muscle with small belly dividing into two slips, which inserted on to the second and third digits on the right leg, whereas on the left leg divided into three slips, which inserted on to the second, third and fourth digits. There was also an accessory EDL muscle arising from the middle third of the medial surface of the fibula and inserted on to the fifth digit in the left foot, and it inserted on to the fourth and fifth digits in the right foot. To our knowledge, such variation hasn't been reported in literature and apprehension of such variations is important for surgeons and orthopaedicians with regards to contractures and surgical procedures concerning the anterior leg and dorsum of the foot.

在对一名61岁女性尸体进行常规下肢解剖时,发现两腿的指长伸肌(EDL)发生了罕见的变异。一种有小腹的EDL肌肉,分为两个卡瓦,插入右腿的第二和第三指,而左腿上分为三个卡瓦,插入第二,第三和第四指。还有一个附属EDL肌起源于腓骨内侧表面的中间三分之一并插入到左脚的第五指,它插入到右脚的第四和第五指。据我们所知,此类变异尚未在文献中报道,了解此类变异对外科医生和骨科医生在处理腿前侧和足背挛缩和手术过程中很重要。
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引用次数: 0
Ankle and Distal Tibia Megaprostheses in Orthopedic Oncology: A Report of Two Cases and Review of the Literature. 踝关节和胫骨远端大型假体在骨科肿瘤中的应用:两例报告及文献复习。
Q3 Medicine Pub Date : 2024-01-01 Epub Date: 2024-12-04 DOI: 10.15388/Amed.2024.31.2.13
Edoardo Ipponi, Martina Cordoni, Elena Bechini, Fabrizia Gentili, Fabio Cosseddu, Antonio D'Arienzo, Lorenzo Andreani

Background: The distal tibia is one of the rarest sites for the onset of malignant and locally aggressive bone tumors. When diagnosed, these lesions should undergo surgical resection with wide margins to eradicate the disease. In the era of limb-sparing surgery, several reconstructive approaches have been proposed and described in modern literature for reconstructing the distal tibia and the ankle. The 3D-printed custom-made prostheses represent an innovative and promising reconstructive option. Several authors highlighted that despite being expensive and prone to some complications such as talar collapse or loosening and soft tissue necrosis, the megaprostheses of the distal tibia could lead to good functional outcomes, also allowing a better range of motion compared to the most common arthrodesis.

Materials and methods: We report two cases who suffered from malignant bone tumors localized in the distal tibia and treated with wide resections and the implant of 3D printed custom-made megaprostheses to replace the distal tibia and the ankle.

Results: Both patients had excellent functional results (MSTS 30/30) one year after surgery. No local recurrence occurred during the patients' latest follow-up.

Conclusions: Our results support the effectiveness of custom-made implants in replacing the distal tibia and the ankle in orthopedic oncology.

背景:胫骨远端是恶性和局部侵袭性骨肿瘤发病最罕见的部位之一。当诊断出这些病变时,应进行大切缘手术切除以根除疾病。在保肢手术时代,现代文献中提出并描述了几种重建胫骨远端和踝关节的方法。3d打印定制假肢代表了一种创新和有前途的重建选择。几位作者强调,尽管价格昂贵且容易出现一些并发症,如距骨塌陷或松动和软组织坏死,但胫骨远端大型假体可以带来良好的功能结果,与最常见的关节融合术相比,还可以提供更好的活动范围。材料和方法:我们报告了2例胫骨远端恶性骨肿瘤,采用大面积切除和3D打印定制大型假体植入胫骨远端和踝关节。结果:两例患者术后1年功能恢复良好(MSTS 30/30)。最近一次随访未见局部复发。结论:我们的研究结果支持定制植入物在骨科肿瘤中替代胫骨远端和踝关节的有效性。
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引用次数: 0
Clinical and Electrophysiological Evaluation of Electrical Stimulation in Patients with Bell's Palsy. 电刺激治疗贝尔氏麻痹的临床及电生理评价。
Q3 Medicine Pub Date : 2024-01-01 Epub Date: 2024-12-04 DOI: 10.15388/Amed.2024.31.2.19
Fatma Çelik, Aylin Ayyıldız, Selda Çiftci İnceoğlu, Figen Yılmaz, Mustafa Çelik, Banu Kuran

Background: The objective of this study is to assess the clinical and electrophysiological effectiveness of electrical stimulation in patients diagnosed Bell's palsy (BP), and to examine its impact on potential complications that may arise during the course of the illness.

Methods: Thirty patients diagnosed with BP were enrolled and randomized into two treatment groups of 15 patients each. The treatment group (TG) received 15 sessions of electrical stimulation (ES), infrared, and exercise therapy, 5 days a week for 3 weeks, while the control group (CG) received sham ES, infrared, and exercise therapy. Evaluations were conducted by electromyography before treatment and at 1 and 3 months after the end of treatment for all patients.

Results: When evaluating patients in both groups based on the side where the BP developed, electrophysiological examination showed an increase in the rate of synkinesis in both the TG and CG. However, there was no statistically significant difference between the two groups. The study found that ES did not reduce the presence of synkinesis in denervated muscles. However, the nerve conduction studies of the studied branches of the facial nerve showed a decrease in distal latencies and an increase in amplitudes of compound muscle action potentials, indicating that ES has a positive effect on nerve regeneration.

Conclusion: ES resulted in a notable reduction in distal latency values within the treatment group. Additionally, ES was found to significantly alleviate depressive symptoms, although it did not result in an improvement in overall quality of life. Therefore, ES is considered a safe treatment method that can be used in the treatment of BP.

背景:本研究的目的是评估电刺激对诊断为贝尔麻痹(BP)的患者的临床和电生理效果,并检查其对病程中可能出现的潜在并发症的影响。方法:30例确诊为BP的患者随机分为两组,每组15例。治疗组(TG)接受15次电刺激(ES)、红外线和运动疗法,每周5天,持续3周;对照组(CG)接受假ES、红外线和运动疗法。在治疗前和治疗结束后1个月和3个月对所有患者进行肌电图评估。结果:两组患者根据血压发生的侧位进行评估时,电生理检查显示TG和CG的联合作用率均有所增加。但两组间无统计学差异。研究发现,ES并没有减少失神经支配肌肉中联动性的存在。然而,面神经所研究分支的神经传导研究显示远端潜伏期减少,复合肌肉动作电位振幅增加,表明ES对神经再生有积极作用。结论:ES使治疗组远端潜伏期值显著降低。此外,研究发现ES可以显著缓解抑郁症状,但不能改善整体生活质量。因此,ES被认为是一种安全的治疗方法,可以用于治疗BP。
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引用次数: 0
Regeneration of Rabbit Auricular Cartilage After the Intravenous Stem Cell Injection 静脉注射干细胞后兔耳廓软骨的再生
Q3 Medicine Pub Date : 2023-11-22 DOI: 10.15388/amed.2023.30.2.15
P. Virych, N. Shuvalova, Anton F. Karas, Galina Karas, Svitlana Chaika, T. Kucherenko, Ganna Y. Minina, Marina Timchenko, Oleg Melnykov, Yurii Minin
Background. The restoration of auricular cartilage is a major problem of otolaryngology. The low regenerative capacity of cartilage requires alternative approaches such as cell and tissue engineering. Stem cells are one of the ways to repair auricular cartilage damages. The aim of the investigation was the regeneration of an artificial defect of the auricular cartilage of rabbits after the intravenous injection of stem cells.Materials and Methods. The study was carried out on rabbits. A narrow strip of auricular cartilage was surgically removed. A previously prepared suspension of homologous mesenchymal stem cells (5 million) in 0.5 ml physiological solution was injected into the vein of the opposite ear. Tissue samples from the site of the injury were collected after 1, 2, and 3 months. Histological examinations of the tissues were carried out after staining with fuchsin-eosin, azure II–eosin, and according to Weigert. In addition, the amount of interleukin-6 (IL-6) and the transforming growth factor β1 (TGF-β1) in the blood serum were determined.Results. The main method of healing is the formation of a connective tissue scar. Yret, an increase of the number of fibroblasts and single islands of the newly formed auricular cartilage was found, which indicates the migration of the injected stem cells to the site of the damage and settling there. The intravenous injection of stem cells did not affect the secretion of pro-inflammatory IL-6, but significantly increased the amount of TGF-β1.Conclusions. We assume that regenerative processes were stimulated. Nevertheless, they were aimed at quickly restoring the tissue integrity through the typical stages of scar formation. The restoration of cartilage integrity requires additional regulatory factors which will determine the chondrogenic differentiation of stem cells.
背景。耳廓软骨的修复是耳鼻喉科的一大难题。软骨的再生能力较低,因此需要采用细胞和组织工程等替代方法。干细胞是修复耳软骨损伤的方法之一。这项研究的目的是在静脉注射干细胞后,对兔子耳廓软骨的人工缺损进行再生。研究以兔子为对象。通过手术切除一条狭长的耳廓软骨。将事先在 0.5 毫升生理溶液中制备好的同种间充质干细胞悬浮液(500 万个)注入对耳静脉。1个月、2个月和3个月后,从受伤部位采集组织样本。用紫红-伊红、天蓝 II-伊红染色后,根据 Weigert 标准对组织进行组织学检查。此外,还测定了血清中白细胞介素-6(IL-6)和转化生长因子β1(TGF-β1)的含量。愈合的主要方法是结缔组织瘢痕的形成。结果发现,新形成的耳软骨的成纤维细胞和单个岛屿的数量增加,这表明注射的干细胞迁移到损伤部位并在那里定居。静脉注射干细胞不会影响促炎性 IL-6 的分泌,但会显著增加 TGF-β1 的含量。我们认为干细胞刺激了再生过程。然而,它们的目的是通过疤痕形成的典型阶段迅速恢复组织的完整性。软骨完整性的恢复需要额外的调节因子,这些因子将决定干细胞的软骨分化。
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引用次数: 0
Narrative Literature Review of Potential Atrial Fibrillation Mechanism of Action Induced by Discontinuation of Benzodiazepines 关于停用苯二氮卓类药物诱发心房颤动潜在作用机制的叙述性文献综述
Q3 Medicine Pub Date : 2023-11-15 DOI: 10.15388/amed.2023.30.2.14
Agnė Okulevičiūtė, Gabija Laubner Sakalauskienė
Introduction: Benzodiazepines are commonly prescribed but often misused, leading to dependence and withdrawal symptoms. Increased worldwide prescriptions raise adverse effects and overdose concerns, especially for the elderly. Caution is needed in prescribing and considering alternative treatments to minimize risks. Aim: Narrative literature review of potential atrial fibrillation mechanism of action induced by discontinuation of benzodiazepines. Materials and methods: Database PubMed was searched using the combination of keywords – “Benzodiazepine AND atrial fibrillation OR peripheral benzodiazepine receptors”, “history of benzodiazepines”, “benzodiazepines mechanism of action”, “benzodiazepines indications”, “benzodiazepines adverse effects” and “benzodiazepines withdrawal effects”. Non-full-text and non-English scientific publications were removed. A total of 31 publication was included. Discussion: Benzodiazepines (BZDs) were synthesized in 1955 and initially considered less toxic than barbiturates. They interact with GABA-A receptors, causing hyperpolarization and inhibitory effects in the central nervous system. BZDs are used to treat various clinical disorders, but long-term use can lead to adverse effects and withdrawal symptoms. There is evidence that genetic diversity can influence the response to BZDs through GABA receptors. The interaction between benzodiazepines and peripheral benzodiazepine receptors may influence calcium ion channels, affecting cardiac action potential and contractility, and discontinuation of these medications can potentially contribute to atrial fibrillation. Additionally, benzodiazepines may directly affect calcium channels, causing antiarrhythmic effects and vasodilation. Conclusion: In summary, benzodiazepines, once considered safer sedatives, now raise concerns about misuse, dependence, and withdrawal symptoms. While there is a potential link between discontinuing benzodiazepines and atrial fibrillation through mechanisms involving peripheral benzodiazepine receptors and cardiac calcium channels, causality remains uncertain and multifaceted. Further research is needed to clarify these mechanisms, and healthcare providers should exercise caution in long-term benzodiazepine prescriptions while exploring alternative treatment strategies to mitigate risks.
简介:苯二氮卓类药物是常用处方药,但经常被滥用,导致依赖性和戒断症状。全球处方量的增加引发了不良反应和用药过量的担忧,尤其是对老年人而言。在处方和考虑替代疗法时需要谨慎,以尽量降低风险。目的:对停用苯二氮卓类药物可能诱发心房颤动的作用机制进行叙述性文献综述。材料与方法:使用 "苯二氮卓类药物和心房颤动或外周苯二氮卓受体"、"苯二氮卓类药物的历史"、"苯二氮卓类药物的作用机制"、"苯二氮卓类药物的适应症"、"苯二氮卓类药物的不良反应 "和 "苯二氮卓类药物的戒断效应 "等关键词组合检索数据库PubMed。删除了非全文和非英文科学出版物。共纳入 31 篇出版物。讨论苯二氮卓类药物(BZDs)于 1955 年合成,最初被认为毒性低于巴比妥类药物。它们与 GABA-A 受体相互作用,导致中枢神经系统超极化和抑制作用。BZDs 可用于治疗各种临床疾病,但长期使用会导致不良反应和戒断症状。有证据表明,遗传多样性可通过 GABA 受体影响对 BZDs 的反应。苯二氮卓类药物与外周苯二氮卓受体之间的相互作用可能会影响钙离子通道,从而影响心脏动作电位和收缩力,停用这些药物有可能导致心房颤动。此外,苯二氮卓类药物可能直接影响钙离子通道,导致抗心律失常作用和血管扩张。结论总之,苯二氮卓类药物曾被认为是较安全的镇静剂,但现在却引起了人们对滥用、依赖性和戒断症状的担忧。虽然通过涉及外周苯二氮卓受体和心脏钙通道的机制,停用苯二氮卓类药物与心房颤动之间存在潜在联系,但因果关系仍不确定,且涉及多个方面。需要进一步研究以明确这些机制,医疗保健提供者应谨慎对待苯二氮卓类药物的长期处方,同时探索替代治疗策略以降低风险。
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引用次数: 0
Fetal Sacrococcygeal Teratoma: A Case Report of a Giant Tumor with an Excellent Outcome 胎儿骶尾部畸胎瘤:巨大肿瘤的病例报告,结果良好
Q3 Medicine Pub Date : 2023-11-15 DOI: 10.15388/amed.2023.30.2.13
Anna Kornete, D. Bokučava, Natalija Vedmedovska
Sacrococcygeal teratoma (SCT) occurs in approximately 1 per 20,000–40,000 births and is the most frequently encountered fetal teratoma, with 75% of cases observed in female fetuses. SCT can be detected on ultrasound as early as the first trimester, presenting as a large mass originating from the sacrococcygeal area, with or without an intrapelvic component. The prenatal course for most fetuses with SCT is generally uneventful, with only a few cases experiencing obstetric and fetal complications. We present the case of a 19-year-old woman who was in good health and had no relevant family or medical history. She was gravida 2 and para 1. During the first trimester scan, an examination revealed a heterogeneous mass in the presacral area with a predominantly multicystic appearance, measuring 12 mm in diameter. At 21+6 weeks of gestation, the Type 2 fetal SCT showed an increase in volume with the size of 49×37×36 mm and contiune to increase in size. The male fetus was delivered by elective Cesarean section at 38 weeks of gestation. The resection of the tumor and coccyx was performed when the newborn was 7 days old. The tumor measured 190×160×100 mm and weighed 1100 g. Pathological examination confirmed the diagnosis of a mature teratoma (Grade 0), and the resection margins were negative. Our case report highlights a fetus with a large and rapidly growing SCT, yet the outcome was excellent.
骶尾部畸胎瘤(Sacrococcygeal teratoma,SCT)的发生率约为每 2 万至 4 万名新生儿中 1 例,是最常见的胎儿畸胎瘤,75% 的病例可见于女性胎儿。胎儿畸胎瘤最早可在妊娠头三个月的超声检查中发现,表现为起源于骶尾部的巨大肿块,伴有或不伴有骨盆内成分。大多数 SCT 胎儿的产前过程一般都很顺利,只有少数病例会出现产科和胎儿并发症。我们介绍了一例 19 岁女性的病例,她健康状况良好,无相关家族史或病史。她的孕期为 2 月 1 日。在妊娠头三个月的扫描中,检查发现骶前区有一个异质肿块,主要呈多囊性,直径为 12 毫米。妊娠 21+6 周时,2 型胎儿 SCT 显示体积增大,大小为 49×37×36 毫米,并继续增大。男胎在妊娠 38 周时选择剖宫产。在新生儿出生 7 天时,对肿瘤和尾骨进行了切除。病理检查确诊为成熟畸胎瘤(0 级),切除边缘呈阴性。我们的病例报告强调了胎儿患有巨大且生长迅速的 SCT,但结果却很好。
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引用次数: 0
Muscle Architecture of Leg Muscles: Functional and Clinical Significance 腿部肌肉的结构:功能和临床意义
Q3 Medicine Pub Date : 2023-11-14 DOI: 10.15388/amed.2023.30.2.12
Gurpreet Kaur, R. Lalwani, Manal M. Khan, Sunita A Athavale
Background. Architectural properties of the muscles are the prime predictors of functional attributes and force-generating capacity of the muscles. This data is vital for musculoskeletal modelling and selecting the appropriate muscle–tendon units for tendon transfers.Cadaveric data for architectural properties is the gold standard and primary input for musculoskeletal modelling. There is a paucity of these datasets, especially in the leg muscles.Methods. Sixty muscles of the anterior and lateral compartments from twelve formalin-fixed lower limbs were studied for gross architecture, including the peculiar fibre arrangements and architectural properties of muscles. Muscle weight, muscle length, fibre length, pennation angle and sarcomere length were measured. Normalised fibre length, fibre length to muscle length ratio (FL/ML ratio), and the physiological cross-sectional area (PCSA) were calculated from the obtained data.Results. Muscles displayed a combination of architectural strategies and were partly fusiform and partly pennate. The tibialis anterior and peroneus longus were the heaviest muscles in their respective compartments and showed more extensive origin from the nearby deep facial sheets.Long fibre length and less pennation angle were seen in muscles of the extensor compartment. Potential muscle power was highest in the tibialis anterior and peroneus longus and least in the extensor hallucis longus.Conclusions. Arching of the foot and eversion are peculiar to humans and recent in evolution. Due to the functional demand of maintaining the medial longitudinal arch and eversion, the tibialis anterior and peroneus longus have more muscle weight and larger physiological cross-sectional area and are potentially more powerful.Extensor compartment muscles were architecturally more suited for excursions because of the long fibre length and less pennation angle.This study contributes baseline normative data for musculoskeletal modelling platforms and simulation tools – an emerging area in biomechanics and tendon transfers.
背景。肌肉的结构特性是肌肉功能属性和发力能力的主要预测指标。这些数据对于肌肉骨骼建模和选择合适的肌肉-肌腱单位进行肌腱转移至关重要。尸体结构特性数据是肌肉骨骼建模的黄金标准和主要输入数据。这些数据集非常缺乏,尤其是腿部肌肉。我们对来自 12 个福尔马林固定的下肢前部和侧部的 60 块肌肉进行了大体结构研究,包括肌肉的特殊纤维排列和结构特性。测量了肌肉重量、肌肉长度、纤维长度、五棱角和肌节长度。根据获得的数据计算归一化纤维长度、纤维长度与肌肉长度比率(FL/ML 比率)和生理横截面积(PCSA)。肌肉显示出多种结构策略,部分呈纺锤形,部分呈羽状。胫骨前肌和腓骨长肌是各自部位中最重的肌肉,并显示出更广泛的起源于附近的深面片。胫骨前肌和腓骨长肌的潜在肌肉力量最大,而拇长伸肌最小。足弓和足外翻是人类特有的现象,也是最近才出现的进化现象。由于维持内侧纵弓和足外翻的功能需求,胫骨前肌和腓骨长肌的肌肉重量更大,生理横截面积更大,可能更有力量。
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引用次数: 0
Post-COVID-19 Syndrome and Related Dysautonomia: Reduced Quality of Life, Increased Anxiety and Manifestation of Depressive Symptoms: Evidence from Greece covid -19后综合征和相关的自主神经异常:生活质量下降、焦虑增加和抑郁症状表现:来自希腊的证据
Q3 Medicine Pub Date : 2023-10-18 DOI: 10.15388/amed.2023.30.2.6
Petros Galanis, Aglaia Katsiroumpa, Irene Vraka, Katerina Kosiara, Olga Siskou, Olympia Konstantakopoulou, Theodoros Katsoulas, Parisis Gallos, Daphne Kaitelidou
Background: Post-COVID-19 syndrome affects a significant number of SARS-CoV-2 infected individuals, even in asymptomatic cases causing several neurological and neuropsychiatric symptoms and signs.Materials and Methods: An online cross-sectional study with a convenience sample was conducted in Greece from November 2022 to January 2023. We measured the demographic and clinical characteristics of patients with post-COVID-19 dysautonomia in terms of the quality of life with the EQ-5D-3L, and anxiety and depressive symptoms by employing Patient Health Questionnaire-4.Results: The study population included 122 patients with post-COVID-19 syndrome. One out of four patients (27.8%) manifested post-COVID-19 dysautonomia, while the mean duration of COVID-19 symptoms was 11.6 months. Anxiety and depressive symptoms were worse after the post-COVID-19 syndrome (p<0.001 in both cases). A statistically significant reduction in quality of life was observed among patients after the post-COVID-19 syndrome (p<0.001 for both EQ-5D-3L index value and EQ-5D-3L VAS). Post-COVID-19 dysautonomia increased depression symptoms after developing the post-COVID-19 syndrome (p=0.02). We found a negative relationship between the duration of COVID-19 symptoms and the quality of life (p<0.001). Moreover, our results showed that depressive symptoms were more common among females after the post-COVID-19 syndrome (p=0.01). Also, the quality of life was lower among females than males (p=0.004 for EQ-5D-3L index value, and p=0.007 for EQ-5D-3L VAS).Conclusions: Our results suggest that post-COVID-19 syndrome causes a tremendous impact on the patients’ quality of life and mental health. In addition, we found that the groups most psychologically affected were patients with post-COVID-19 dysautonomia, females, and patients with a longer duration of symptoms. Policy makers should assign priority rights to vulnerable groups in future psychiatric planning. Policy measures should focus on the mental health of post-COVID-19 patients who seem to be particularly vulnerable.
背景:covid -19后综合征影响大量SARS-CoV-2感染者,即使在无症状病例中也会引起几种神经和神经精神症状和体征。材料和方法:从2022年11月到2023年1月,在希腊进行了一项方便样本的在线横断面研究。我们采用《患者健康问卷-4》(Patient Health Questionnaire-4)测量了covid -19后自主神经异常患者的人口学特征和临床特征,包括EQ-5D-3L的生活质量以及焦虑和抑郁症状。结果:研究人群包括122例covid -19后综合征患者。1 / 4的患者(27.8%)出现新型冠状病毒感染后自主神经异常,平均持续时间为11.6个月。焦虑和抑郁症状在covid -19综合征后加重(p<0.001)。covid -19综合征后患者的生活质量下降具有统计学意义(EQ-5D-3L指数值和EQ-5D-3L VAS的p<均为0.001)。出现covid -19后综合征后,自主神经异常加重了抑郁症状(p=0.02)。我们发现COVID-19症状持续时间与生活质量呈负相关(p<0.001)。此外,我们的研究结果显示,女性在covid -19综合征后出现抑郁症状更为常见(p=0.01)。此外,女性的生活质量低于男性(EQ-5D-3L指数值p=0.004, EQ-5D-3L VAS p=0.007)。结论:我们的研究结果表明,covid -19后综合征对患者的生活质量和心理健康造成了巨大的影响。此外,我们发现心理上受影响最大的群体是covid -19后自主神经紊乱患者、女性和症状持续时间较长的患者。在未来的精神病学规划中,决策者应优先考虑弱势群体。政策措施应侧重于似乎特别脆弱的covid -19后患者的心理健康。
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Acta Medica Lituanica
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