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Magnetic Resonance Imaging Appearance of Giant Intracerebral Tuberculoma: A Retrospective Analysis 巨大脑结核瘤的磁共振成像表现回顾性分析
Q3 Medicine Pub Date : 2022-12-13 DOI: 10.15388/amed.2022.29.2.19
Deb K. Boruah, K. Sarma, Pallavi Gogoi, Binoy K. Singh, Bidyut B. Gogoi, Karuna Hazarika, B. Sharma, P. Phukan
Background: Giant intracerebral tuberculomas are rare lesions but should be considered in the differential diagnosis of intracranial space-occupying lesion in an endemic region.Objective: The purpose of this study is to analyze the clinical data and magnetic resonance imaging (MRI) findings of giant intracerebral tuberculomas to improve the diagnostic precision.Material and Methods: The clinical and MRI findings of 22 patients of giant intracerebral tuberculoma were analyzed retrospectively. For the statistical analysis independent sample Student t-test was used.Results: For 22 patients included in this sample the giant intracerebral tuberculoma was of size more than 2.5cm. The majority of the giant tuberculomas (19 patients (86.4%))was located in the supratentorial area.T2-weighted hypointense core of giant tuberculoma was observed in 12 patients (54.5%) and T1 hyperintensities were observed in peripheral (wall) of the giant tuberculoma in 14 patients (63.6%). The mean ADC value of the peripheral (wall) of the giant tuberculoma was 1.034± 0.466[SD] x 10-3mm2/s and the core was 0.994± 0.455[SD] x 10-3mm2/s with a statistically significant difference (p-value <0.0005) in between. MR spectroscopy showed raised lipid peak at 0.9 to 1.33 ppm in 10 patients (45.5%),raised lipid-lactate peak in 12 patients (54.5%),raised Choline/Cr ratio more than 1.2 in 14 patients(63.6%) and Choline/Cr ratio less than 1.2 in 5 patients (22.7%). Associated involvement of lung was observed in the 6patients (27.3%), cervical lymph node in 1 patient (4.5%) and spine in 1patient (4.5%).Conclusions: MRI plays a vital role in distinguishing giant intracerebral tuberculomas from other intracranial space-occupying lesions, thereby allows the early institution of anti-tubercular treatment (ATT), decreased patient morbidity, mortality, and prevents unnecessary neurosurgical excision.
背景:巨大的脑内结核瘤是一种罕见的病变,但在地方性颅内占位性病变的鉴别诊断中应予以考虑。目的:分析巨大脑内结核瘤的临床资料和MRI表现,提高诊断的准确性。材料与方法:回顾性分析22例巨大脑内结核瘤的临床和MRI表现。统计分析采用独立样本Student t检验。结果:22例患者的巨大脑内结核瘤大小超过2.5cm,其中大部分(19例(86.4%))位于幕上区。12例(54.5%)观察到T2加权低信号核心,14例(63.6%)观察到T1高信号。巨大结核瘤外周(壁)平均ADC值为1.034±0.466[SD]×10-3mm2/s,核心为0.994±0.455[SD]x 10-3mm2/s。差异有统计学意义(p值<0.0005)。磁共振波谱显示,10例(45.5%)患者的脂质峰值在0.9至1.33ppm处升高,12例(54.5%)患者脂质乳酸峰值升高,14例(63.6%)患者的胆碱/Cr比值升高超过1.2,5例(22.7%)患者的胆碱酯酶/Cr比值低于1.2,结论:MRI在区分巨大脑内结核瘤和其他颅内占位性病变方面起着至关重要的作用,从而可以早期进行抗结核治疗,降低患者的发病率和死亡率,并防止不必要的神经外科切除。
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引用次数: 0
Risk Factors of Chronic Kidney Disease after Partial Nephrectomy 肾部分切除术后慢性肾脏疾病的危险因素
Q3 Medicine Pub Date : 2022-12-12 DOI: 10.15388/amed.2022.29.2.18
J. Makevičius, B. Kirstukaite, A. Želvys, F. Jankevicius, M. Miglinas, R. Komiagienė
Background: In comparison with radical nephrectomy, partial nephrectomy (PN) is considered a better option for small renal mass surgery, because of optimal kidney tissue removal and parenchyma preservation. But there are patients with worsening postoperative renal function (RF) and chronic kidney disease (CKD) after PN. Therefore, the study aimed to evaluate and detect risk factors for CKD after PN.Materials and Methods. A prospective observational study was conducted, which consisted of 91 individuals who received PN with warm ischemia and an estimated preoperative glomerular filtration rate (eGFR) ≥ 60 ml/min/1.72m2 without pathologic albuminuria. Preoperative and intraoperative factors like intraoperative hypotension (IOH), blood loss, and resected part volume were analyzed.Results. At 6-month follow-up, 14 (15.4 %) patients experienced postoperative CKD. After 12 months of follow-up, 15 (16.5 %) patients had CKD. Patients with CKD had a lower preoperative eGFR than non-CKD group (69.0 vs 91.0 ml/min/1.72m2, p < 0.001), longer ischemia (20.0 vs 14.0, p = 0.002) and IOH time (40.0 (40.0; 47.5) vs 0.0 (0.0; 26.2) min, p < 0.001). Also, higher volumes of resected kidney part tumor and removed parenchyma with higher glomerulosclerosis amounts (73.3 % vs 14.5 %, p = 0.009) were found in CKD group. Estimated blood loss > 500 ml during PN was discovered to be the major risk factor for CKD development (OR 11.13, 95 % CI 1.88–65.92, p = 0.008). Furthermore, kidney resected part volume (OR 1.05, 95% CI 1.05-1.10, p = 0.033) and IOH time (OR 1.11, 95% CI 1.03-1.19, p = 0.005) were identified as risk factors for postoperative CKD. Conclusions. Patients after PN are at an increased risk of CKD development. Most commonly, postoperative CKD occurs in the first 6 months after PN and appears stable after 12 months of follow-up. Blood loss > 500 ml during PN, IOH and resected kidney volume can have an impact on postoperative RF and increase the risk of CKD.
背景:与根治性肾切除术相比,部分肾切除术(PN)被认为是小肾脏肿块手术的更好选择,因为它可以最佳地切除肾组织和保存实质。但也有患者在PN术后肾功能(RF)和慢性肾脏疾病(CKD)恶化。因此,本研究旨在评估和检测PN术后CKD的危险因素。材料和方法。进行了一项前瞻性观察性研究,该研究由91名接受PN治疗的患者组成,这些患者伴有热缺血,术前肾小球滤过率(eGFR)≥60 ml/min/1.72m2,无病理性蛋白尿。分析术前和术中因素,如术中低血压(IOH)、失血量和切除部分体积。后果在6个月的随访中,14名(15.4%)患者出现了术后CKD。经过12个月的随访,15名(16.5%)患者患有CKD。CKD患者术前eGFR低于非CKD组(69.0 vs 91.0 ml/min/1.72m2,p<0.001),缺血时间更长(20.0 vs 14.0,p=0.002),IOH时间更长(40.0(40.0;47.5)vs 0.0(0.0;26.2)min,p<001)。此外,CKD组切除的肾部分肿瘤和切除的实质体积更大,肾小球硬化量更高(73.3%vs 14.5%,p=0.009)。PN期间估计失血量>500 ml被发现是CKD发展的主要风险因素(OR 11.13,95%CI 1.88-65.92,p=0.008)。此外,肾脏切除部分体积(OR 1.05,95%CI 1.05-10.10,p=0.033)和IOH时间(OR 1.11,95%CI 1.03-1.19,p=0.005)被确定为术后CKD的风险因素。结论。PN后的患者患CKD的风险增加。最常见的是,术后CKD发生在PN后的前6个月,随访12个月后表现稳定。PN、IOH和切除肾体积期间失血量>500 ml会对术后RF产生影响,并增加CKD的风险。
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引用次数: 0
Use of Tranexamic Acid to Reduce PostOperative Bleeding in Orthopaedic Oncology 应用氨甲环酸减少骨科肿瘤术后出血
Q3 Medicine Pub Date : 2022-12-12 DOI: 10.15388/amed.2022.29.2.17
L. Andreani, A. Del Chiaro, E. Ipponi, Federico di Sacco, Martina Caterino, R. Capanna
Background: Orthopaedic oncology often causes major blood losses that may put at risk patients’ hemodynamic balance and their overall clinical stability. To this date, transfusion therapy still represents the pivotal treatment to counterbalance the reduction in hemoglobin levels which occur after surgery. Although effective, transfusions are expensive and inevitably associated with a number of complications and therefore other solutions, such as procoagulative drugs, could play an important role to prevent massive blood losses.Material and methods: We reviewed the clinical intercourse of 37 patients who underwent major bone resection due to malignant tumors of the lower limb. Cases were divided in two different groups: group G1 consisting of 12 patients treated intraoperatively with tranexamic acid and group G2 which was made of 25 controls.Results: On average, patients treated with tranexamic acid (G1) required transfusion of 3.9 concentrated blood cells units during surgery and 0.9 units during the postoperative course. Other patients (G2), for their part, required on average 3.1 units intraoperatively and 2.1 units postoperatively. No significant difference was found in intraoperative transfusion rate (p=0.402). Instead, postoperative transfusions were significantly less frequent for patients treated with tranexamic acid (p=0.023). None of the 12 patients treated with tranexamic acid had evidence of Deep Vein Thrombosis.Conclusion: Our outcomes indicate that the use of TXA was effective in reducing blood losses also for major surgical interventions in orthopedic oncology.
背景:骨科肿瘤学通常会导致严重的血液损失,这可能会危及患者的血液动力学平衡和整体临床稳定性。到目前为止,输血治疗仍然是抵消术后血红蛋白水平下降的关键治疗方法。尽管有效,但输血费用高昂,不可避免地会出现许多并发症,因此其他解决方案,如促凝药物,可以在防止大量失血方面发挥重要作用。材料与方法:回顾性分析37例下肢恶性肿瘤大骨切除患者的临床资料。病例分为两组:G1组由12名术中接受氨甲环酸治疗的患者组成,G2组由25名对照组组成。结果:平均而言,接受氨甲环酸(G1)治疗的患者在手术期间需要输注3.9个浓缩血细胞单位,在术后过程中需要输注0.9个单位。其他患者(G2)术中平均需要3.1个单位,术后平均需要2.1个单位。术中输血率无显著差异(p=0.402),接受氨甲环酸治疗的患者术后输血的频率明显降低(p=0.023)。12名接受氨甲环环酸治疗患者中没有一名有深静脉血栓形成的证据。结论:我们的结果表明,TXA的使用在减少血液损失方面是有效的,在骨科肿瘤学的主要手术干预中也是如此。
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引用次数: 0
Predictors of Real-World Parents' Acceptance to Vaccinate Their Children Against the COVID-19. 现实世界中家长接受为子女接种 COVID-19 疫苗的预测因素。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-07-26 DOI: 10.15388/Amed.2021.29.1.4
Petros Galanis, Irene Vraka, Olga Siskou, Olympia Konstantakopoulou, Aglaia Katsiroumpa, Ioannis Moisoglou, Daphne Kaitelidou

Background: As the COVID-19 pandemic continues to threaten public health, the vaccination of children against the disease appears to be a key factor to control the pandemic. Our aim was to investigate the prevalence of parents who have vaccinated their children against the COVID-19 and the factors influencing this decision.

Materials and methods: We conducted a web-based cross-sectional study in Greece during the first week of September 2021. The study questionnaire was distributed through social media and a convenience sample was obtained. Only parents with children aged 12-17 years old could participate in the study. We collected socio-demographic data of parents and we measured their attitudes towards vaccination and COVID-19 pandemic.

Results: Study population included 656 parents. Regarding vaccination, 27.1% of parents had their children vaccinated against the COVID-19, while almost all children had a complete vaccination history (98.9%). The most important reasons for decline of COVID-19 vaccination were doubts about the safety and effectiveness of COVID-19 vaccines (45.3%) and fear of side effects (36.6%). Regarding the information about the COVID-19 vaccines, parents showed more trust in family doctors than in scientists and the government. We found that increased parents' age, increased trust in COVID-19 vaccines, and positive attitude of parents towards vaccination had a positive effect on children's vaccination.

Conclusions: Understanding the factors influencing parents' decision to vaccinate their children against the COVID-19 is crucial to increase the COVID-19 vaccination coverage rate. Implementation of public health policies is necessary to spread knowledge about COVID-19 vaccines and to regain vaccine confidence.

背景:由于 COVID-19 大流行继续威胁着公众健康,为儿童接种该疾病疫苗似乎是控制大流行的一个关键因素。我们的目的是调查已为子女接种 COVID-19 疫苗的父母的比例以及影响这一决定的因素:我们于 2021 年 9 月的第一周在希腊开展了一项基于网络的横断面研究。研究问卷通过社交媒体发布,并获得了便利样本。只有子女年龄在 12-17 岁之间的父母才能参与研究。我们收集了家长的社会人口学数据,并测量了他们对疫苗接种和 COVID-19 大流行的态度:研究对象包括 656 名家长。在疫苗接种方面,27.1%的家长为其子女接种了COVID-19疫苗,而几乎所有儿童都有完整的疫苗接种史(98.9%)。拒绝接受 COVID-19 疫苗接种的最主要原因是对 COVID-19 疫苗的安全性和有效性存在疑虑(45.3%)和害怕副作用(36.6%)。关于 COVID-19 疫苗的信息,家长对家庭医生的信任度高于对科学家和政府的信任度。我们发现,家长年龄的增加、对 COVID-19 疫苗信任度的增加以及家长对接种疫苗的积极态度对儿童接种疫苗有积极影响:结论:了解影响家长决定为其子女接种 COVID-19 疫苗的因素对于提高 COVID-19 疫苗接种率至关重要。有必要实施公共卫生政策,以普及 COVID-19 疫苗知识并重塑疫苗信心。
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引用次数: 0
Vertigo and Ischemic Stroke after Hyperextension (Beauty Parlour Stroke syndrome). 过度伸展后的眩晕和缺血性中风(Beauty Parlour中风综合征)。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-06-29 DOI: 10.15388/Amed.2022.29.2.2
Bünyamin Tosunoğlu, Sultan Merve Ünal, Seyfi Emre Aksoy, Tahir Kurtuluş Yoldaş

Beauty parlour stroke syndrome is a stroke syndrome that occurs secondary to hyperextension of the neck due to compression of the vertebral artery in the atlanto-occipital region. It was first defined as "pearl beauty stroke syndrome" in 1992 by Weintraub et al. Vertigo syndrome caused by cervical region pathologies, bad posture of the neck and/or trauma [1]. We present a young, 23-year-old patient who has no disease, no trauma history nor substance-drug use. He was diagnosed with vertigo that started after going to the barber's and then had an infarction in the cerebellum.

美容院中风综合征是一种继发于寰枕区椎动脉压迫导致颈部过度伸展的中风综合征。1992年,Weintraub等人首次将其定义为“珍珠美人中风综合征”。由颈部病变、颈部不良姿势和/或创伤引起的眩晕综合征[1]。我们介绍了一名23岁的年轻患者,他没有疾病,没有创伤史,也没有药物使用。他在去理发店后被诊断为眩晕,随后小脑梗死。
{"title":"Vertigo and Ischemic Stroke after Hyperextension (Beauty Parlour Stroke syndrome).","authors":"Bünyamin Tosunoğlu,&nbsp;Sultan Merve Ünal,&nbsp;Seyfi Emre Aksoy,&nbsp;Tahir Kurtuluş Yoldaş","doi":"10.15388/Amed.2022.29.2.2","DOIUrl":"https://doi.org/10.15388/Amed.2022.29.2.2","url":null,"abstract":"<p><p>Beauty parlour stroke syndrome is a stroke syndrome that occurs secondary to hyperextension of the neck due to compression of the vertebral artery in the atlanto-occipital region. It was first defined as \"pearl beauty stroke syndrome\" in 1992 by Weintraub et al. Vertigo syndrome caused by cervical region pathologies, bad posture of the neck and/or trauma [1]. We present a young, 23-year-old patient who has no disease, no trauma history nor substance-drug use. He was diagnosed with vertigo that started after going to the barber's and then had an infarction in the cerebellum.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 2","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9799011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitudes toward COVID-19 Pandemic among Fully Vaccinated Individuals: Evidence from Greece Two Years after the Pandemic. 完全接种疫苗的个人对新冠肺炎大流行的态度:大流行两年后来自希腊的证据。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-06-29 DOI: 10.15388/Amed.2022.29.2.11
Petros Galanis, Irene Vraka, Aglaia Katsiroumpa, Olga Siskou, Olympia Konstantakopoulou, Theodoros Katsoulas, Theodoros Mariolis-Sapsakos, Daphne Kaitelidou

Background: Considering the major effects of COVID-19 pandemic on health, social, economic, and political dimensions of all countries, positive attitudes toward COVID-19 pandemic are essential to control the pandemic. In our study, we investigated attitudes toward COVID-19 pandemic among fully COVID-19 vaccinated individuals two years after the pandemic and we identified predictors of attitudes.

Materials and methods: We conducted an on-line cross-sectional study with 815 fully COVID-19 vaccinated individuals in Greece during May 2022. A self-administered and valid questionnaire was disseminated through social media platforms. We measured socio-demographic variables and COVID-19-related variables as potential predictors of attitudes toward COVID-19 pandemic. The outcome variable was attitudes toward COVID-19 pandemic (compliance with hygiene measures, trust in COVID-19 vaccination, fear of COVID-19, and information regarding the COVID-19 pandemic and vaccination).

Results: We found a very high level of compliance with hygiene measures, a high level of trust and information about the COVID-19 pandemic and vaccination, and a moderate level of fear of COVID-19. Also, we identified that females, participants with a higher educational level, those with a chronic disease, those with a better self-perceived physical health, and those without a previous COVID-19 diagnosis adhered more in hygiene measures. Trust in COVID-19 vaccination was higher among females, older participants, those with a higher educational level, those with a better self-perceived physical health, and those without a previous COVID-19 diagnosis. Moreover, females, older participants, those with a higher educational level, those with a chronic disease, those with a better self-perceived physical health, those that received a flu vaccine in previous season, and those without a previous COVID-19 diagnosis experienced more fear of COVID-19. Finally, level of information regarding COVID-19 pandemic and vaccination was higher for participants with a higher educational level, those without a chronic disease, those with a better self-perceived physical health, and those that received a flu vaccine in previous season.

Conclusions: Understanding predictors of attitudes toward COVID-19 pandemic among fully vaccinated individuals is crucial for developing appropriate public health campaigns in the future. Vaccination should be accompanied by positive attitudes in order to decrease the frequency of negative outcomes of COVID-19, such as hospitalization, complications and mortality.

背景:考虑到新冠肺炎大流行对所有国家的健康、社会、经济和政治层面的重大影响,对新冠肺炎大流行持积极态度对于控制大流行至关重要。在我们的研究中,我们调查了在大流行两年后完全接种新冠肺炎疫苗的人对新冠肺炎大流行的态度,并确定了态度的预测因素。材料和方法:2022年5月,我们对希腊815名完全接种新冠肺炎疫苗的人进行了一项在线横断面研究。通过社交媒体平台分发了一份自我管理的有效问卷。我们测量了社会形态变量和新冠肺炎相关变量,作为对新冠肺炎大流行态度的潜在预测因素。结果变量是对新冠肺炎大流行的态度(对卫生措施的遵守、对新冠肺炎疫苗接种的信任、对新冠肺炎的恐惧以及关于新冠肺炎大流行和疫苗接种的信息),以及对新冠肺炎的中度恐惧。此外,我们还发现,女性、教育水平较高的参与者、患有慢性病的参与者、自我感觉身体健康状况较好的参与者以及之前未被诊断为新冠肺炎的参与者更坚持卫生措施。女性、年龄较大的参与者、教育水平较高的参与者、自我认知身体健康状况较好的参与者以及之前未确诊为新冠肺炎的参与者对新冠肺炎疫苗接种的信任度较高。此外,女性、年龄较大的参与者、教育水平较高的参与者、患有慢性病的参与者、自我认知身体健康状况较好的参与者、在上一季接种过流感疫苗的参与者以及之前未被诊断为新冠肺炎的参与者对新冠肺炎的恐惧程度更高。最后,对于教育水平较高的参与者、没有慢性病的参与者、自我感觉身体健康较好的参与者以及在上一季接种流感疫苗的参与者,有关新冠肺炎大流行和疫苗接种的信息水平更高。结论:了解完全接种疫苗的个人对新冠肺炎大流行态度的预测因素对于未来开展适当的公共卫生运动至关重要。接种疫苗时应采取积极态度,以减少新冠肺炎负面结果的发生频率,如住院、并发症和死亡率。
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引用次数: 0
All that Glitters is not Cholecystitis. A Rare Presentation of Acute Pericarditis Mimicking Cholecystitis and Review of the Literature. 闪光点不是胆囊炎。罕见的模拟胆囊炎的急性心包炎表现及文献复习。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-06-29 DOI: 10.15388/Amed.2022.29.2.8
Anna Garmpi, Christos Damaskos, Nikolaos Garmpis, Vasiliki E Georgakopoulou, Vaios Vasileios Kaminiotis, Evangelos Diamantis, Alexandros Patsouras, Athanasios Syllaios, Dimitrios Dimitroulis

Acute pericarditis is the most common inflammatory disorder of the pericardium, responsible for approximately 5% of visits to the emergency departments, concerning chest pain without myocardial infarction. We report a case of a 41-year-old man who presented to our hospital, complaining about retrosternal and epigastrium pain. The transthoracic echocardiogram showed pericardial effusion while the electrocardiogram and laboratory findings revealed acute pericarditis. An abdominal ultrasound revealed gallbladder edema. The pericardial effusion was treated with pericardial catheter insertion, diuretics, and nonsteroidal anti-inflammatory drugs. This case shows that acute pericarditis can be clinically presented with many ways, one of them being gallbladder edema. Furthermore, in this case-based review we present all cases of simultaneous appearance of pericarditis and acalculous cholecystitis or gallbladder edema.

急性心包炎是最常见的心包炎症性疾病,约5%的急诊就诊是由于胸痛而非心肌梗死。我们报告了一例41岁的男性患者,他来到我们的医院,抱怨胸骨后和上腹部疼痛。经胸超声心动图显示心包积液,心电图和实验室检查显示急性心包炎。腹部超声检查显示胆囊水肿。心包积液采用心包导管插入、利尿剂和非甾体抗炎药治疗。该病例表明急性心包炎在临床上有多种表现,其中之一是胆囊水肿。此外,在这篇基于病例的综述中,我们介绍了所有同时出现心包炎和非结石性胆囊炎或胆囊水肿的病例。
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引用次数: 0
Vaccinating with a COVID-19 Vaccine: Experience of the Tertiary Allergology Center. 接种COVID-19疫苗:三级过敏症中心的经验。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-07-26 DOI: 10.15388/Amed.2021.29.1.1
Eglė Žilėnaitė, Laura Malinauskienė, Kęstutis Černiauskas, Linas Griguola, Kotryna Linauskienė, Violeta Kvedarienė, Anželika Chomičienė

Background: Allergic reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but detailed descriptions and further actions are not well characterized.

Objective: To describe the symptoms of possible allergic reactions after the mRNA COVID-19 vaccine and outcomes of further vaccination.

Methods: We descriptively analyzed data of adult (≥18 years of age) patients, who were sent for vaccination to our outpatient center for the Diagnostics and Treatment of Allergic and Immune diseases. All patients were vaccinated with the Pfizer-BioNTech Comirnaty® vaccine.

Results: From January 2021 to July 2021 twenty-two patients were vaccinated in our center. Six patients experienced a reaction after the first Comirnaty® dose in different vaccination centers. The majority of them complained of various types of rashes after the first dose, one case was consistent with anaphylaxis. The latter patient was tested with the skin prick using Pfizer-BioNTech Comirnaty® vaccine and the test was negative. Other sixteen patients were vaccinated in our center from the first dose because of past allergic reactions to other medication or due to concomitant mast cell disorder. All patients were vaccinated without any immediate adverse reactions.

Conclusions: None of our patients experienced repeated cutaneous reactions after the second dose. Patients with previous anaphylaxis or mastocytosis also were safely vaccinated.

背景:基于信使RNA (mRNA)的COVID-19疫苗后的过敏反应已有报道,但详细的描述和进一步的作用尚未得到很好的描述。目的:描述mRNA - COVID-19疫苗接种后可能出现的过敏反应症状及进一步接种后的结果。方法:我们描述性分析成人(≥18岁)患者的资料,这些患者被送到我们的门诊中心进行过敏和免疫疾病的诊断和治疗。所有患者均接种了Pfizer-BioNTech Comirnaty®疫苗。结果:2021年1月至2021年7月,22例患者在我中心接种疫苗。6名患者在不同的疫苗接种中心首次接种Comirnaty®后出现反应。大多数患者在第一次给药后出现不同类型的皮疹,1例符合过敏反应。后一名患者使用Pfizer-BioNTech Comirnaty®疫苗进行皮肤穿刺测试,测试结果为阴性。另有16例患者因既往对其他药物过敏或伴有肥大细胞疾病,从第一次接种起就在本中心接种。所有患者均接种了疫苗,没有立即出现不良反应。结论:我们的患者在第二次给药后没有出现重复的皮肤反应。既往有过敏反应或肥大细胞增多症的患者也安全接种疫苗。
{"title":"Vaccinating with a COVID-19 Vaccine: Experience of the Tertiary Allergology Center.","authors":"Eglė Žilėnaitė,&nbsp;Laura Malinauskienė,&nbsp;Kęstutis Černiauskas,&nbsp;Linas Griguola,&nbsp;Kotryna Linauskienė,&nbsp;Violeta Kvedarienė,&nbsp;Anželika Chomičienė","doi":"10.15388/Amed.2021.29.1.1","DOIUrl":"https://doi.org/10.15388/Amed.2021.29.1.1","url":null,"abstract":"<p><strong>Background: </strong>Allergic reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but detailed descriptions and further actions are not well characterized.</p><p><strong>Objective: </strong>To describe the symptoms of possible allergic reactions after the mRNA COVID-19 vaccine and outcomes of further vaccination.</p><p><strong>Methods: </strong>We descriptively analyzed data of adult (≥18 years of age) patients, who were sent for vaccination to our outpatient center for the Diagnostics and Treatment of Allergic and Immune diseases. All patients were vaccinated with the Pfizer-BioNTech Comirnaty® vaccine.</p><p><strong>Results: </strong>From January 2021 to July 2021 twenty-two patients were vaccinated in our center. Six patients experienced a reaction after the first Comirnaty® dose in different vaccination centers. The majority of them complained of various types of rashes after the first dose, one case was consistent with anaphylaxis. The latter patient was tested with the skin prick using Pfizer-BioNTech Comirnaty® vaccine and the test was negative. Other sixteen patients were vaccinated in our center from the first dose because of past allergic reactions to other medication or due to concomitant mast cell disorder. All patients were vaccinated without any immediate adverse reactions.</p><p><strong>Conclusions: </strong>None of our patients experienced repeated cutaneous reactions after the second dose. Patients with previous anaphylaxis or mastocytosis also were safely vaccinated.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unrecognized Primary Hypoparathyroidism with Severe Hypocalcemia in the Presence of COVID-19 Infection. 未被识别的原发性甲状旁腺功能低下伴严重低钙感染。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-03-15 DOI: 10.15388/Amed.2021.29.1.9
Domas Grigoravičius, Laura Šiaulienė, Žydrūnė Visockienė

Primary hypoparathyroidism (PHPT) is a rare disease most commonly caused by surgical parathyroid glands destruction or genetic disorders. PHPT manifestation varies from subclinical to acute or even lethal symptoms. In atypical presentation the signs of hypocalcemia could be missed, and asymptotic chronic hypocalcemia could manifest only in the presence of exacerbated comorbidities, infections, hypomagnesemia or certain medications. We present a case of PHPT with severe hypocalcemia manifesting as seizures and delirium in a presence of COVID-19 infection.

原发性甲状旁腺功能减退症(PHPT)是一种罕见的疾病,最常见的原因是手术破坏甲状旁腺或遗传疾病。PHPT的表现从亚临床到急性甚至致命症状不等。在不典型的表现中,低钙血症的症状可能会被忽略,而慢性无症状低钙血症只有在存在加重的合并症、感染、低镁血症或某些药物的情况下才会出现。我们提出一个PHPT与严重的低钙血症表现为癫痫发作和谵妄在存在COVID-19感染的情况下。
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引用次数: 2
Appendicitis in a Newborn: Case Report and Review of the Literature. 新生儿阑尾炎一例报告及文献复习。
Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-01-25 DOI: 10.15388/Amed.2021.29.1.3
Eleonora Ivanova, Rasa Garunkštienė, Arūnas Liubšys

Background: Acute appendicitis in a newborn is rare and may be fatal. The reported incidence is 0,04 % to 0,2 %. Diagnosis remains challenging as the symptoms are undefined.

Case presentation: Here we present a full-term newborn boy of 9 days presenting with malaise, reluctance to feed and subfebrile fever. Over the course of 6 days his condition became worse. The newborn was febrile, passed no stool and his stomach became distended. Perforation due to necrotizing enterocolitis was highly suspected. The diagnosis of acute appendicitis was finalized perioperatively after the perforation and worsening condition made the emergency surgery inevitable. After 16 days of admission the patient was discharged in good condition.

Conclusion: Appendicitis in neonates is a dangerous yet manageable condition. While rare it should be included in differential diagnosis when presented with atypical necrotizing enterocolitis or unexplained peritonitis. Quick and accurate diagnosis may increase survival rates.

背景:急性阑尾炎在新生儿中是罕见的,可能是致命的。报道的发病率为0.04%至0.2%。由于症状不明确,诊断仍然具有挑战性。病例介绍:这里我们报告一个9天的足月新生儿,表现为身体不适,不愿进食和低热。在6天的过程中,他的病情恶化了。新生儿发热,不大便,胃胀。由于坏死性小肠结肠炎引起的穿孔被高度怀疑。急性阑尾炎的诊断是在穿孔后围手术期确定的,病情恶化使急诊手术成为必然。入院16天后,患者出院情况良好。结论:新生儿阑尾炎是一种危险但可控制的疾病。虽然罕见,但当出现非典型坏死性小肠结肠炎或不明原因的腹膜炎时,应列入鉴别诊断。快速准确的诊断可以提高生存率。
{"title":"Appendicitis in a Newborn: Case Report and Review of the Literature.","authors":"Eleonora Ivanova,&nbsp;Rasa Garunkštienė,&nbsp;Arūnas Liubšys","doi":"10.15388/Amed.2021.29.1.3","DOIUrl":"https://doi.org/10.15388/Amed.2021.29.1.3","url":null,"abstract":"<p><strong>Background: </strong>Acute appendicitis in a newborn is rare and may be fatal. The reported incidence is 0,04 % to 0,2 %. Diagnosis remains challenging as the symptoms are undefined.</p><p><strong>Case presentation: </strong>Here we present a full-term newborn boy of 9 days presenting with malaise, reluctance to feed and subfebrile fever. Over the course of 6 days his condition became worse. The newborn was febrile, passed no stool and his stomach became distended. Perforation due to necrotizing enterocolitis was highly suspected. The diagnosis of acute appendicitis was finalized perioperatively after the perforation and worsening condition made the emergency surgery inevitable. After 16 days of admission the patient was discharged in good condition.</p><p><strong>Conclusion: </strong>Appendicitis in neonates is a dangerous yet manageable condition. While rare it should be included in differential diagnosis when presented with atypical necrotizing enterocolitis or unexplained peritonitis. Quick and accurate diagnosis may increase survival rates.</p>","PeriodicalId":34365,"journal":{"name":"Acta Medica Lituanica","volume":"29 1","pages":"131-135"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40350763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Acta Medica Lituanica
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