Pub Date : 2023-06-16DOI: 10.26420/jdismarkers.2023.1055
Lakshmi Sai Niharika Janga, Vanaja Rani Bathina, Afnan Akram Nawaz Khan, Raghava Rao Alluri, Sweatha Mani
Chronic Kidney Disease (CKD) is a prevalent health condition that can lead to various cardiovascular complications, including endothelial dysfunction and arterial stiffness. Endothelial dysfunction is characterized by impaired vasodilation, increased vascular permeability, and increased inflammatory response. Arterial stiffness, on the other hand, refers to the reduced ability of the arterial wall to stretch and accommodate the blood flow. Both of these complications contribute to the increased risk of cardiovascular events and mortality in patients with CKD [1]. Vitamin D, a fat-soluble vitamin, plays a crucial role in the regulation of calcium and phosphorus metabolism, bone health, and immune function [2]. Vitamin D deficiency is prevalent in patients with CKD due to reduced synthesis and increased urinary excretion of the active form of vitamin D (1,25-dihydroxyvitamin D) [3]. Vitamin D supplementation has been proposed as a potential therapy to improve cardiovascular outcomes in CKD patients by reducing inflammation, improving endothelial function, and reducing arterial stiffness [4]. The aim of this systematic review is to examine the impact of vitamin D supplementation on endothelial function and arterial stiffness in patients with CKD.
慢性肾脏病（CKD）是一种普遍存在的健康问题，可导致各种心血管并发症，包括内皮功能障碍和动脉僵化。内皮功能障碍的特点是血管舒张功能受损、血管通透性增加和炎症反应加剧。另一方面，动脉僵化是指动脉壁伸展和适应血流的能力下降。这两种并发症都会增加慢性肾脏病患者发生心血管事件和死亡的风险[1]。维生素 D 是一种脂溶性维生素，在调节钙磷代谢、骨骼健康和免疫功能方面起着至关重要的作用 [2]。由于活性维生素 D（1,25-二羟基维生素 D）合成减少和尿排泄增加，维生素 D 缺乏症在慢性肾脏病患者中十分普遍 [3]。维生素 D 补充剂被认为是一种潜在的疗法，可通过减少炎症、改善内皮功能和降低动脉僵化来改善 CKD 患者的心血管预后 [4]。本系统综述旨在研究维生素 D 补充剂对 CKD 患者内皮功能和动脉僵化的影响。
{"title":"The Impact of Vitamin D Supplementation on Endothelial Function and Arterial Stiffness in Patients with Chronic Kidney Disease","authors":"Lakshmi Sai Niharika Janga, Vanaja Rani Bathina, Afnan Akram Nawaz Khan, Raghava Rao Alluri, Sweatha Mani","doi":"10.26420/jdismarkers.2023.1055","DOIUrl":"https://doi.org/10.26420/jdismarkers.2023.1055","url":null,"abstract":"Chronic Kidney Disease (CKD) is a prevalent health condition that can lead to various cardiovascular complications, including endothelial dysfunction and arterial stiffness. Endothelial dysfunction is characterized by impaired vasodilation, increased vascular permeability, and increased inflammatory response. Arterial stiffness, on the other hand, refers to the reduced ability of the arterial wall to stretch and accommodate the blood flow. Both of these complications contribute to the increased risk of cardiovascular events and mortality in patients with CKD [1]. Vitamin D, a fat-soluble vitamin, plays a crucial role in the regulation of calcium and phosphorus metabolism, bone health, and immune function [2]. Vitamin D deficiency is prevalent in patients with CKD due to reduced synthesis and increased urinary excretion of the active form of vitamin D (1,25-dihydroxyvitamin D) [3]. Vitamin D supplementation has been proposed as a potential therapy to improve cardiovascular outcomes in CKD patients by reducing inflammation, improving endothelial function, and reducing arterial stiffness [4]. The aim of this systematic review is to examine the impact of vitamin D supplementation on endothelial function and arterial stiffness in patients with CKD.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-20DOI: 10.26420/jdismarkers.2023.1051
Hyo-Eun Kim, K. Park, Dasom Lee, Soram Lee, Sang-Woon Kim, Tae Soon Hwang, Kyung-Won Hong
Background: Direct-to-Consumer (DTC) genetic testing provides genetic risk to consumers and motivates consumers to take care of their own customized health care. In 2018, we developed and provided a DTC genetic testing service (GENESTART™) in collaboration with Herbalife Korea Co. Ltd. Methods: The analyzed dataset consisted of the body fat percentage (BFP), body mass index (BMI), 31 genetic polymorphism genotypes, and responses to 19 questionnaire items of 24,447 individuals. The genetic main effects for BFP and BMI were examined by linear regression analysis, and the interaction effects were examined using a generalized linear model that controlled age and sex as covariates. Results: In the case of BFP, the sample average was 31.47% overall, 24.76% for men, and 32.79% for women, showing that men had an average BFP that was 8 percentage points lower than that of women. The average BMI was 25.38 overall, 26.45 for men, and 25.17 for women, showing that men had an average BMI of 1.2 kg/m2 higher than that of women. The FTO and MC4R genes, well-known obesity markers, showed a significant correlation with both phenotypes, and the BDNF gene, which is related to stress obesity, showed a highly significant association with BMI but only a weak association with BFP. Among the remaining genes, TRIB1, ABCA1, MYL2, G6PC, GCKR, GLIS3, CYP17A1, HECTD4, and NT5C2 genes showed significant associations with the obesity-related phenotypes. In this study, we found four interaction results for BFP (ABO and fruits, CYP1A2 and sugary foods, FTO and muscle exercise, MC4R and vitamins) and five interactions for BMI (MC4R and proteins, CSK and fruits, MC4R and calcium, DGKB and calcium, CSK and water). Conclusions: This study is expected to enable the provision of personalized and accurate solutions for BFP and BMI management to customers who have undergone genetic testing.
{"title":"Direct-to-Consumer Genetic Test and Lifestyle Questionnaire Analysis of Body Mass Index and Body Fat Percentage in a Large Korean Population","authors":"Hyo-Eun Kim, K. Park, Dasom Lee, Soram Lee, Sang-Woon Kim, Tae Soon Hwang, Kyung-Won Hong","doi":"10.26420/jdismarkers.2023.1051","DOIUrl":"https://doi.org/10.26420/jdismarkers.2023.1051","url":null,"abstract":"Background: Direct-to-Consumer (DTC) genetic testing provides genetic risk to consumers and motivates consumers to take care of their own customized health care. In 2018, we developed and provided a DTC genetic testing service (GENESTART™) in collaboration with Herbalife Korea Co. Ltd. Methods: The analyzed dataset consisted of the body fat percentage (BFP), body mass index (BMI), 31 genetic polymorphism genotypes, and responses to 19 questionnaire items of 24,447 individuals. The genetic main effects for BFP and BMI were examined by linear regression analysis, and the interaction effects were examined using a generalized linear model that controlled age and sex as covariates. Results: In the case of BFP, the sample average was 31.47% overall, 24.76% for men, and 32.79% for women, showing that men had an average BFP that was 8 percentage points lower than that of women. The average BMI was 25.38 overall, 26.45 for men, and 25.17 for women, showing that men had an average BMI of 1.2 kg/m2 higher than that of women. The FTO and MC4R genes, well-known obesity markers, showed a significant correlation with both phenotypes, and the BDNF gene, which is related to stress obesity, showed a highly significant association with BMI but only a weak association with BFP. Among the remaining genes, TRIB1, ABCA1, MYL2, G6PC, GCKR, GLIS3, CYP17A1, HECTD4, and NT5C2 genes showed significant associations with the obesity-related phenotypes. In this study, we found four interaction results for BFP (ABO and fruits, CYP1A2 and sugary foods, FTO and muscle exercise, MC4R and vitamins) and five interactions for BMI (MC4R and proteins, CSK and fruits, MC4R and calcium, DGKB and calcium, CSK and water). Conclusions: This study is expected to enable the provision of personalized and accurate solutions for BFP and BMI management to customers who have undergone genetic testing.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"10 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132512801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-10DOI: 10.26420/jdismarkers.2023.1050
Araujo Zaida, Lopez-Ramos Juan Ernesto, Enciso-Moreno Jose Antonio, de Waard Jacobus Henri, R. Bruno, Vanegas Magnolia, Patarroyo Manuel Alfonso
Objective: Global Tuberculosis (TB) eradication efforts must also focus on detecting and treating cases of Latent TB Infection (LTBI); persons with LTBI can progress to active TB at any time, often many years or even decades after the initial infection, thereby serving as a source of new infections. Methods: The aim was evaluated the diagnostic accuracy of the combination of serological host biomarkers that may support the differentiation between LTBI and Non-Infected (NI) individuals. A total of 182 adult Warao Amerindians were included; cases with LTBI (n=103) and Non-Infected (NI) individuals (n=79). The Real-time quantitative PCR (qPCR) was performed on all peripheral blood samples from Warao Amerindians and analyzed transcriptional immune biomarkers (i.e., IFN-γ, CD14, MMP-9, CCR5, CCL11, CXCL9/MIG, and uPAR/PLAUR proteins) under stimulation condition with ESAT-6, CFP10, and TB7.7 Mycobacterium Tuberculosis (Mtb)-antigens. Additionally, Enzyme-Linked Immunosorbent Assays (ELISA) were performed for evaluating host biomarker anti-synthetic peptides (5 ESAT-6 and 17 Ag85A synthetic peptides) covering Mtb antigen sequences. Results: The approach’s diagnostic information was compared using Receiver Operating Characteristic (ROC) curves. The ROC analysis revealed high biosignature discriminative ability for the relative gene expression of MMP-9 high levels (AUC=0.799 ± 0.071: 0.640 - 0.917, 95% CI), p < 0.002) between LTBI and NI; additionally IgG anti-synthetic peptide; ESAT-6 P-12037 (AUC=0.640; 0.545-0.735 95% CI, p<0.007) allowed differentiation between LTBI and NI or healthy ones. Conclusion: The accuracy of the MMP-9/IgG anti-P-12037 combination could have a high discriminative ability for diagnosing LTBI; such an approach holds promise for further validation.
{"title":"Immune Biomarker Combinations for Diagnosis Monitoring of Latent Tuberculosis Infection","authors":"Araujo Zaida, Lopez-Ramos Juan Ernesto, Enciso-Moreno Jose Antonio, de Waard Jacobus Henri, R. Bruno, Vanegas Magnolia, Patarroyo Manuel Alfonso","doi":"10.26420/jdismarkers.2023.1050","DOIUrl":"https://doi.org/10.26420/jdismarkers.2023.1050","url":null,"abstract":"Objective: Global Tuberculosis (TB) eradication efforts must also focus on detecting and treating cases of Latent TB Infection (LTBI); persons with LTBI can progress to active TB at any time, often many years or even decades after the initial infection, thereby serving as a source of new infections. Methods: The aim was evaluated the diagnostic accuracy of the combination of serological host biomarkers that may support the differentiation between LTBI and Non-Infected (NI) individuals. A total of 182 adult Warao Amerindians were included; cases with LTBI (n=103) and Non-Infected (NI) individuals (n=79). The Real-time quantitative PCR (qPCR) was performed on all peripheral blood samples from Warao Amerindians and analyzed transcriptional immune biomarkers (i.e., IFN-γ, CD14, MMP-9, CCR5, CCL11, CXCL9/MIG, and uPAR/PLAUR proteins) under stimulation condition with ESAT-6, CFP10, and TB7.7 Mycobacterium Tuberculosis (Mtb)-antigens. Additionally, Enzyme-Linked Immunosorbent Assays (ELISA) were performed for evaluating host biomarker anti-synthetic peptides (5 ESAT-6 and 17 Ag85A synthetic peptides) covering Mtb antigen sequences. Results: The approach’s diagnostic information was compared using Receiver Operating Characteristic (ROC) curves. The ROC analysis revealed high biosignature discriminative ability for the relative gene expression of MMP-9 high levels (AUC=0.799 ± 0.071: 0.640 - 0.917, 95% CI), p < 0.002) between LTBI and NI; additionally IgG anti-synthetic peptide; ESAT-6 P-12037 (AUC=0.640; 0.545-0.735 95% CI, p<0.007) allowed differentiation between LTBI and NI or healthy ones. Conclusion: The accuracy of the MMP-9/IgG anti-P-12037 combination could have a high discriminative ability for diagnosing LTBI; such an approach holds promise for further validation.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134494955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-02DOI: 10.26420/jdismarkers.2022.1049
C. L, H. c, F. Q, L. P, Gao Yh, Li Wl, Chen Jy, Zhang Hw, Q. T.
Carney-Stratakis Syndrome (CSS), first described in 2002 [1], encompasses Gastrointestinal Stromal Tumors (GISTs) and Paragangliomas (PGLs) and has autosomal dominant inheritance with incomplete penetrance [2]. Germline mutations of Succinate Dehydrogenase (SDH) complex subunits and consequent SDH functional deficiency have been identified as responsible for CSS [3]. Here, we present a case with a new mutation site in SDHB that has not yet been reported.
{"title":"A New Mutation Site of Succinate Dehydrogenase-Related Carney-Stratakis Syndrome: A Case Report","authors":"C. L, H. c, F. Q, L. P, Gao Yh, Li Wl, Chen Jy, Zhang Hw, Q. T.","doi":"10.26420/jdismarkers.2022.1049","DOIUrl":"https://doi.org/10.26420/jdismarkers.2022.1049","url":null,"abstract":"Carney-Stratakis Syndrome (CSS), first described in 2002 [1], encompasses Gastrointestinal Stromal Tumors (GISTs) and Paragangliomas (PGLs) and has autosomal dominant inheritance with incomplete penetrance [2]. Germline mutations of Succinate Dehydrogenase (SDH) complex subunits and consequent SDH functional deficiency have been identified as responsible for CSS [3]. Here, we present a case with a new mutation site in SDHB that has not yet been reported.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122926092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-25DOI: 10.26420/jdismarkers.2022.1048
Xin F, S. L, J. L., Zhi-Bin W
Background: Type 2 Diabetes Mellitus (T2DM) is currently one of the most prominent and global chronic conditions. In recent years, it has been found that macromolecular polysaccharide has a significant effect on T2DM, various polysaccharides such as Angelica Sinensis Polysaccharide (ASP), Poriacocos polysaccharide and Atractylodesmacrocephala polysaccharide in DSS have effects on T2DM, but mechanism of polysaccharides of DSS(p-DSS) at the metabolic level is still unclear. The purpose of this work is to study the male and female mechanisms of p-DSS in treating T2DM based on metabolomics. Materials and Methods: In this study, metabolomics was used to elucidate the therapeutic mechanism of DSS in T2DM. Urinary samples were collected from male and female rats with T2DM, induced by a high-sugar and high-fat diet combined with Streptozotocin (STZ), to measure the levels of biochemical markers. Urinary metabolomics-based analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was conducted to evaluate the differential metabolites from multiple metabolic pathways. Results: After treatment with p-DSS for 4 weeks, biochemical indicators, including Fasting Blood Glucose (FBG), Fasting Insulin (FINS), Oral Glucose Tolerance Test (OGTT), Insulin Tolerance Test (ITT) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), were significantly improved. Metabolomics results revealed that p-DSS regulated the biomarkers, such as PC, 2-oxoglutarate, NAAG in TCA cycle and alanine, aspartate and glutamate metabolism for male rats, on the contrary, leukotriene B4, cholic acid in arachidonic acid metabolism and primary bile acid biosynthesis for female rats. Conclusions: Based on metabolomics, the mechanisms of p- DSS in male and female rats are not identical.
{"title":"UPLC-QTOF-MS-Based Metabolomics Reveal the Effect of Polysaccharides from Danggui-Shaoyao-San in Type 2 Diabetic Male and Female Rats","authors":"Xin F, S. L, J. L., Zhi-Bin W","doi":"10.26420/jdismarkers.2022.1048","DOIUrl":"https://doi.org/10.26420/jdismarkers.2022.1048","url":null,"abstract":"Background: Type 2 Diabetes Mellitus (T2DM) is currently one of the most prominent and global chronic conditions. In recent years, it has been found that macromolecular polysaccharide has a significant effect on T2DM, various polysaccharides such as Angelica Sinensis Polysaccharide (ASP), Poriacocos polysaccharide and Atractylodesmacrocephala polysaccharide in DSS have effects on T2DM, but mechanism of polysaccharides of DSS(p-DSS) at the metabolic level is still unclear. The purpose of this work is to study the male and female mechanisms of p-DSS in treating T2DM based on metabolomics. Materials and Methods: In this study, metabolomics was used to elucidate the therapeutic mechanism of DSS in T2DM. Urinary samples were collected from male and female rats with T2DM, induced by a high-sugar and high-fat diet combined with Streptozotocin (STZ), to measure the levels of biochemical markers. Urinary metabolomics-based analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was conducted to evaluate the differential metabolites from multiple metabolic pathways. Results: After treatment with p-DSS for 4 weeks, biochemical indicators, including Fasting Blood Glucose (FBG), Fasting Insulin (FINS), Oral Glucose Tolerance Test (OGTT), Insulin Tolerance Test (ITT) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), were significantly improved. Metabolomics results revealed that p-DSS regulated the biomarkers, such as PC, 2-oxoglutarate, NAAG in TCA cycle and alanine, aspartate and glutamate metabolism for male rats, on the contrary, leukotriene B4, cholic acid in arachidonic acid metabolism and primary bile acid biosynthesis for female rats. Conclusions: Based on metabolomics, the mechanisms of p- DSS in male and female rats are not identical.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126103444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-16DOI: 10.26420/jdismarkers.2022.1047
P. D, P. T, Sharma A
Alzheimer’s Disease is a prominent neurodegenerative disorder affecting the age group 60 and above. Cholinergic hypothesis, amyloid β cascade, oxidative stress is some of the known etiologies of marked importance to name a few. We have undertaken a computational analysis where fifteen phytochemicals were selected. These natural molecules were studied and analysed against acetylcholinesterase, butyrlcholinesterase, BACE and amyloid β monomer and protofibril. The binding affinities of Genistein, Huperzine A, kaempferol, Methyl quercetin, Paclitaxel and Withinolide A against AChE and BuChE enzymes were found to be -7.7 to -8.6 Kcal/mol, respectively. Various phytochemicals like Genistein, kaempferol, Piceatannol, Ginkgolide B, Methyl quercetin and Withinolide A were found to bind the BACE-1 enzyme with the binding affinities of -6.7 to -7.9 Kcal/mol. All the phytochemicals experienced efficient binding towards Aβ monomer and Aβ protofibril. Withinolide A was found to bind all the PDB’s efficiently with binding affinity of -8.4, -8.9, -7.7, -6.6 and -6.8 Kcal/mol against AChE enzyme, BuChE enzyme, BACE-1 enzyme, Aβ monomer and Aβ protofibril, respectively as a result it can be carried forward for the further preclinical and clinical studies.
{"title":"Phytochemicals as Potential Anti-Alzheimer’s Agents- An In-Silico Evidence","authors":"P. D, P. T, Sharma A","doi":"10.26420/jdismarkers.2022.1047","DOIUrl":"https://doi.org/10.26420/jdismarkers.2022.1047","url":null,"abstract":"Alzheimer’s Disease is a prominent neurodegenerative disorder affecting the age group 60 and above. Cholinergic hypothesis, amyloid β cascade, oxidative stress is some of the known etiologies of marked importance to name a few. We have undertaken a computational analysis where fifteen phytochemicals were selected. These natural molecules were studied and analysed against acetylcholinesterase, butyrlcholinesterase, BACE and amyloid β monomer and protofibril. The binding affinities of Genistein, Huperzine A, kaempferol, Methyl quercetin, Paclitaxel and Withinolide A against AChE and BuChE enzymes were found to be -7.7 to -8.6 Kcal/mol, respectively. Various phytochemicals like Genistein, kaempferol, Piceatannol, Ginkgolide B, Methyl quercetin and Withinolide A were found to bind the BACE-1 enzyme with the binding affinities of -6.7 to -7.9 Kcal/mol. All the phytochemicals experienced efficient binding towards Aβ monomer and Aβ protofibril. Withinolide A was found to bind all the PDB’s efficiently with binding affinity of -8.4, -8.9, -7.7, -6.6 and -6.8 Kcal/mol against AChE enzyme, BuChE enzyme, BACE-1 enzyme, Aβ monomer and Aβ protofibril, respectively as a result it can be carried forward for the further preclinical and clinical studies.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122941723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-28DOI: 10.26420/jdismarkers.2022.1046
J. Z, C. L, Liu Z, Zhou L, Ding N, Z. H, Liu P, Li B, Wu Y, Yu B, Yang J
Aim: The study aimed to estimate the association between characterizations on coronary computed tomography angiography (CCTA) and cardiovascular events in type 2 diabetic patients at high/very high cardiovascular risk without known coronary artery disease (CAD), to investigate the incremental value of CCTA in these individuals. Methods: 82 type 2 diabetes patients without known CAD were enrolled according to the 2019 European Society of Cardiology (ESC) guidelines of high/ very high cardiovascular risk. The coronary artery calcium score, plaque location and extent and composition, stenosis severity, and epicardial adipose tissue (EAT) volume were evaluated. The cardiovascular events included cardiac death, non-fatal myocardial infarction, coronary revascularization, non-fatal stroke, hospitalization for unstable angina, and hospitalization for congestive heart failure during a mean follow-up period of 4.7±1.5 years. Univariate analysis and multivariate regression were used to obtain independent risk factors for CVEVs in these patients. The increased discriminative value after the addition of CAD features and EATS volume to the established clinical risk factors were estimated using the area under a receiver-operating characteristic curve (AUC). Results: CVEVs occurred in 26.8% of the patients. Independent predictors of CVEVs included hypertension (odds ratio (OR) 3.844, P=0.020), diabetes duration (OR 1.129, P=0.049), creatinine (OR 1.072, P=0.022), ABOS (OR 1.729, P=0.031), SSS (OR 1.213, P=0.021), and EAT volume (OR 1.025, P=0.012) The combination of ABOS, SSS and clinical risk factors improved the identify of CVEVs, with an area under the receiver operating characteristic curve of 0.955 (95% confidence interval 0.885 to 0.989; P=0.004) for the prediction of the endpoints. Conclusion: The extent and severity of overall coronary atheroma burden and EAT volume based on CCTA are associated with long-term CVEVs for type 2 diabetic patients at high/very high cardiovascular risk. CCTA has incremental value in evaluating the heterogeneity of such subclinical patients and beneficial forewarning for these individuals with CVEVs.
{"title":"Coronary Artery Disease Features and Epicardial Adipose on CT are Predictive Factors for Cardiovascular Events in Type 2 Diabetic Patients at High/Very High Cardiovascular Risk: A Pilot Retrospective Study","authors":"J. Z, C. L, Liu Z, Zhou L, Ding N, Z. H, Liu P, Li B, Wu Y, Yu B, Yang J","doi":"10.26420/jdismarkers.2022.1046","DOIUrl":"https://doi.org/10.26420/jdismarkers.2022.1046","url":null,"abstract":"Aim: The study aimed to estimate the association between characterizations on coronary computed tomography angiography (CCTA) and cardiovascular events in type 2 diabetic patients at high/very high cardiovascular risk without known coronary artery disease (CAD), to investigate the incremental value of CCTA in these individuals. Methods: 82 type 2 diabetes patients without known CAD were enrolled according to the 2019 European Society of Cardiology (ESC) guidelines of high/ very high cardiovascular risk. The coronary artery calcium score, plaque location and extent and composition, stenosis severity, and epicardial adipose tissue (EAT) volume were evaluated. The cardiovascular events included cardiac death, non-fatal myocardial infarction, coronary revascularization, non-fatal stroke, hospitalization for unstable angina, and hospitalization for congestive heart failure during a mean follow-up period of 4.7±1.5 years. Univariate analysis and multivariate regression were used to obtain independent risk factors for CVEVs in these patients. The increased discriminative value after the addition of CAD features and EATS volume to the established clinical risk factors were estimated using the area under a receiver-operating characteristic curve (AUC). Results: CVEVs occurred in 26.8% of the patients. Independent predictors of CVEVs included hypertension (odds ratio (OR) 3.844, P=0.020), diabetes duration (OR 1.129, P=0.049), creatinine (OR 1.072, P=0.022), ABOS (OR 1.729, P=0.031), SSS (OR 1.213, P=0.021), and EAT volume (OR 1.025, P=0.012) The combination of ABOS, SSS and clinical risk factors improved the identify of CVEVs, with an area under the receiver operating characteristic curve of 0.955 (95% confidence interval 0.885 to 0.989; P=0.004) for the prediction of the endpoints. Conclusion: The extent and severity of overall coronary atheroma burden and EAT volume based on CCTA are associated with long-term CVEVs for type 2 diabetic patients at high/very high cardiovascular risk. CCTA has incremental value in evaluating the heterogeneity of such subclinical patients and beneficial forewarning for these individuals with CVEVs.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131727430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-03DOI: 10.26420/jdismarkers.2021.1045
L. B, Skarżyńska E, Zborowska H, Strawa A, J. A.
Background: Ratios of total serum protein (TP) concentrations to serum protein electrophoretic fractions could reflect impact on intravascular homeostasis in pregnancy of qualitative and quantitative changes in highabundance protein of serum between consecutive trimesters. Methods: TP concentrations were measured by biuret method and six protein fractions were separated by electrophoresis in 186 serum samples from 65 healthy pregnant women in each trimester of normal singleton pregnancy and from 20 non-pregnant women. Results: TP/fraction ratios in pregnancy and postpartum period differed from those in non-pregnancy. Ratios of TP/ protein fractions changed across trimesters, mostly between first and second trimesters with increase in TP / albumin ratio by 5% while ratios TP/alpha-1-, TP/alpha-2- and TP/beta-1- globulin decreased by 22%, 15% and 15%, respectively. TP/gamma-globulin ratio increased by 15% between second and third trimesters. Conclusions: Ratios of TP concentrations to specific protein fractions may reflect trimester-specific qualitative and quantitative changes in serum content of high-abundance proteins and their effect on serum protein homeostasis in pregnancy. Decreased ratios of TP to alpha-1-, alpha-2-, beta-1- and beta-2- globulins confirm increases in concentrations of individual proteins contained in these fractions with development of pregnancy, with largest increase in level of alpha-1-globulin in earliest period of pregnancy
{"title":"The Ratios of Total Serum Protein to Protein Electrophoretic Fractions during Pregnancy as Diagnostic Information","authors":"L. B, Skarżyńska E, Zborowska H, Strawa A, J. A.","doi":"10.26420/jdismarkers.2021.1045","DOIUrl":"https://doi.org/10.26420/jdismarkers.2021.1045","url":null,"abstract":"Background: Ratios of total serum protein (TP) concentrations to serum protein electrophoretic fractions could reflect impact on intravascular homeostasis in pregnancy of qualitative and quantitative changes in highabundance protein of serum between consecutive trimesters. Methods: TP concentrations were measured by biuret method and six protein fractions were separated by electrophoresis in 186 serum samples from 65 healthy pregnant women in each trimester of normal singleton pregnancy and from 20 non-pregnant women. Results: TP/fraction ratios in pregnancy and postpartum period differed from those in non-pregnancy. Ratios of TP/ protein fractions changed across trimesters, mostly between first and second trimesters with increase in TP / albumin ratio by 5% while ratios TP/alpha-1-, TP/alpha-2- and TP/beta-1- globulin decreased by 22%, 15% and 15%, respectively. TP/gamma-globulin ratio increased by 15% between second and third trimesters. Conclusions: Ratios of TP concentrations to specific protein fractions may reflect trimester-specific qualitative and quantitative changes in serum content of high-abundance proteins and their effect on serum protein homeostasis in pregnancy. Decreased ratios of TP to alpha-1-, alpha-2-, beta-1- and beta-2- globulins confirm increases in concentrations of individual proteins contained in these fractions with development of pregnancy, with largest increase in level of alpha-1-globulin in earliest period of pregnancy","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129583778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-22DOI: 10.26420/jdismarkers.2021.1044
W. X, Long Q, H. Q, L. J, S. Y, Zhao Jy, L. F
Objective: To investigate the difference of clinical outcomes between patients with and without Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP) after camrelizumab treatment. Methods: A retrospective, matched case-control study was designed. A total of 92 patients with advanced solid tumors treated with camrelizumab at xx hospital between July 2019 and October 2020 were included, of whom 16 patients developed RCCEP (RCCEP group) and the remaining 76 served as the control group. The primary endpoint is Progression-Free Survival (PFS), and the secondary endpoint is Objective Response Rate (ORR) and Overall Survival (OS). Multivariate Cox regression analysis is used to assess the relevant indicators of PFS. Results: Compared with the control group, significantly increased ORR was observed in patients with RCCEP (56.3% vs 19.7%) (P<0.05). The PFS was 13 months (5-15 months) in the RCCEP group and 6 months (2-11 months) in the control group. Compared with the control group, the PFS was significantly higher in the RCCEP group (HR=0.555, 95% CI: 0.278-0.985, P<0.05). In multivariate Cox regression, RCCEP remained statistically significant after excluding potential confounders (HR=0.312, 95% CI: 0.095-0.637, P<0.01) and was associated with PFS in patients. Conclusion: In camrelizumab treatment, the occurrence of RCCEP may be a marker of strong immune response and improved tumor treatment outcomes, and has potential predictive value in patient efficacy and prognosis.
{"title":"Clinical Outcomes of Patients with Advanced Solid Tumors of Cutaneous Capillary Hyperplasia Following Treatment with Camrelizumab: A Retrospective Case-Control Study","authors":"W. X, Long Q, H. Q, L. J, S. Y, Zhao Jy, L. F","doi":"10.26420/jdismarkers.2021.1044","DOIUrl":"https://doi.org/10.26420/jdismarkers.2021.1044","url":null,"abstract":"Objective: To investigate the difference of clinical outcomes between patients with and without Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP) after camrelizumab treatment. Methods: A retrospective, matched case-control study was designed. A total of 92 patients with advanced solid tumors treated with camrelizumab at xx hospital between July 2019 and October 2020 were included, of whom 16 patients developed RCCEP (RCCEP group) and the remaining 76 served as the control group. The primary endpoint is Progression-Free Survival (PFS), and the secondary endpoint is Objective Response Rate (ORR) and Overall Survival (OS). Multivariate Cox regression analysis is used to assess the relevant indicators of PFS. Results: Compared with the control group, significantly increased ORR was observed in patients with RCCEP (56.3% vs 19.7%) (P<0.05). The PFS was 13 months (5-15 months) in the RCCEP group and 6 months (2-11 months) in the control group. Compared with the control group, the PFS was significantly higher in the RCCEP group (HR=0.555, 95% CI: 0.278-0.985, P<0.05). In multivariate Cox regression, RCCEP remained statistically significant after excluding potential confounders (HR=0.312, 95% CI: 0.095-0.637, P<0.01) and was associated with PFS in patients. Conclusion: In camrelizumab treatment, the occurrence of RCCEP may be a marker of strong immune response and improved tumor treatment outcomes, and has potential predictive value in patient efficacy and prognosis.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122508863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-19DOI: 10.26420/jdismarkers.2021.1042
A. Rodríguez-Morata, Reyes-Ortega Jp, R. Ml, F. Gallardo-Pedrajas, G. Ja
Ovarian Vein Syndrome (OVS) is a rare and a controversial disease caused by varicose veins, a crossing and dilated ovarian veins inducing chronic ureteral obstruction [1]. We report a case of a woman with a large history of chronic abdominal pain and urinary symptoms with left chronical ureteral obstruction successfully treated by transvenous embolization with coils and foam.
{"title":"Ovarian Vein Syndrome in a Woman with Abdominal Pain","authors":"A. Rodríguez-Morata, Reyes-Ortega Jp, R. Ml, F. Gallardo-Pedrajas, G. Ja","doi":"10.26420/jdismarkers.2021.1042","DOIUrl":"https://doi.org/10.26420/jdismarkers.2021.1042","url":null,"abstract":"Ovarian Vein Syndrome (OVS) is a rare and a controversial disease caused by varicose veins, a crossing and dilated ovarian veins inducing chronic ureteral obstruction [1]. We report a case of a woman with a large history of chronic abdominal pain and urinary symptoms with left chronical ureteral obstruction successfully treated by transvenous embolization with coils and foam.","PeriodicalId":344125,"journal":{"name":"Journal of Disease Markers","volume":"567 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123322228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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