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Antibiotic resistance as a medical problem 抗生素耐药性是一个医学问题
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010033
R. S. Kozlov, A. Y. Kuzmenkov, A. G. Vinogradova
The growth and spread of antimicrobial resistance (AMR) is one of the main threats to the healthcare system. Currently, along with the development of new antimicrobial drugs (AMPs) the basic approach to countering the spread of AMR is the rational use of existing medicines. Selection of the optimal drug taking into account its activity, doses, frequency and route of administration are the basis of rational antimicrobial therapy. However, due to widespread availability of AMR, availability of up-to-date information on activity of AMP is extremely important. Therefore, monitoring of antibiotic resistance is a key activity to ensure providing the evidence base on which antimicrobial formularies should be drawn up drugs and treatment protocols. In the solution of these problems in the Russian Federation active role plaies the Methodological Verification Center on Antimicrobial Resistance – Reference center for clinical pharmacology, created on the basis of the Research Institute of Antimicrobial Chemotherapy of the Smolensk State Medical University of the Ministry of Health of Russian Federation.
抗菌药耐药性(AMR)的增长和蔓延是医疗系统面临的主要威胁之一。目前,在开发新型抗菌药物(AMPs)的同时,应对 AMR 扩散的基本方法是合理使用现有药物。根据药物的活性、剂量、给药频率和途径选择最佳药物是合理抗菌治疗的基础。然而,由于 AMR 的广泛存在,提供有关 AMP 活性的最新信息极为重要。因此,对抗生素耐药性的监测是一项关键工作,以确保为制定抗菌药物目录和治疗方案提供证据基础。在解决这些问题的过程中,俄罗斯联邦抗菌药物耐药性方法验证中心(临床药理参考中心)发挥了积极作用,该中心是在俄罗斯联邦卫生部斯摩棱斯克国立医科大学抗菌药物化疗研究所的基础上建立的。
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引用次数: 0
Antibiotic resistance as a factor, hindering the fight against infectious animal diseases 抗生素耐药性是阻碍防治动物传染病的一个因素
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010049
A. M. Gulyukin, A. V. Kapustin, A. V. Mishchenko
The presented review outlines the generally significant problem of antibiotic resistance. The authors outline the main causes of this phenomenon, possible measures to reduce antibiotic resistance in veterinary medicine, as well as strategies aimed at preventing the development of resistant strains. Alternative means of combating infectious diseases are considered.
本综述概述了抗生素耐药性这一普遍存在的重大问题。作者概述了造成这一现象的主要原因、减少兽医抗生素耐药性的可行措施以及旨在防止耐药菌株发展的战略。此外还考虑了其他防治传染病的方法。
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引用次数: 0
National system for microbiological monitoring of microorganisms resistant to antimicrobial drugs 对抗菌药物产生抗药性的微生物国家监测系统
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010026
V. G. Akimkin
Antimicrobial resistance in pathogens is a global problem associated with millions of additional deaths per year. In addition to the risks to human, animal and environmental health, this phenomenon undermines the functioning of agri-food systems. Rospotrebnadzor is doing its best to counteract the spread of antibiotic resistance in Russia, both through medical organizations and through food products. The Central Research Institute of Epidemiology of Rospotrebnadzor has established the heterogeneity of populations of ESKAPE pathogens. t has been shown that even within the same line, pathogenic isolates can have their own distinctive features formed during the process of evolution. The clonal similarity of strains isolated from food, as well as the circulation in the food chain of transmissible genes KPC, NDM, MBLBS, which cause multidrug resistance in bacteria, pose a threat to public health. For timely and adequate diagnosis, carrying out epidemiological surveillance and preventing the widespread spread of antimicrobial resistance, the institute’s specialists are developing sets of reagents that allow prompt detect single genes associated with resistance directly in biological material. Currently, domestic scientists are working on creating a system for monitoring resistant strains and genetic determinants of resistance (genomic epidemiological surveillance).
病原体的抗菌药耐药性是一个全球性问题,每年造成数百万人死亡。除了对人类、动物和环境健康造成风险外,这一现象还破坏了农业食品系统的运作。俄罗斯国家食品药品监督管理局(Rospotrebnadzor)正通过医疗机构和食品,尽最大努力遏制抗生素耐药性在俄罗斯的蔓延。Rospotrebnadzor 流行病学中央研究所已经确定了 ESKAPE 病原体种群的异质性。事实证明,即使在同一品系中,病原体分离株在进化过程中也会形成自己的独特特征。从食物中分离出的菌株具有克隆相似性,而且可传播基因 KPC、NDM、MBLBS 在食物链中流通,导致细菌产生多重耐药性,这些都对公共卫生构成威胁。为了进行及时、充分的诊断,开展流行病学监测,防止抗菌药耐药性的广泛传播,该研究所的专家们正在开发成套试剂,以便能够直接在生物材料中迅速检测出与耐药性相关的单个基因。目前,国内科学家正在努力创建一个监测抗药性菌株和抗药性基因决定因素(基因组流行病学监测)的系统。
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引用次数: 0
Innovative radiopharmaceuticals in cancer diagnostics and radionuclide therapy 癌症诊断和放射性核素治疗中的创新放射性药物
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010088
V. I. Chernov
The article presents the development trends of nuclear medicine in oncology. It has been shown that the main trends in modern radiopharmaceutics are closely related to theranostics, i.e., the use of radiopharmaceuticals obtained on the basis of a single delivery vector labeled with diagnostic and therapeutic radionuclides. In nuclear medicine, this approach has found application for the individualization and planning of radionuclide therapy. The results of our own research aimed at the development of radiopharmaceuticals for the diagnosis and radionuclide therapy of cancer are presented.
文章介绍了肿瘤学核医学的发展趋势。研究表明,现代放射性药物学的主要趋势与治疗学密切相关,即使用以诊断和治疗放射性核素为标记的单一给药载体获得放射性药物。在核医学中,这种方法被应用于放射性核素治疗的个体化和规划。本文介绍了我们在开发用于癌症诊断和放射性核素治疗的放射性药物方面的研究成果。
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引用次数: 0
Global agroforestry projects and their implementation 全球农林项目及其实施情况
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010071
K. N. Kulik, A. I. Belyaev, A. M. Pugacheva, A. A. Zykova
Desertification of lands as one of the most acute environmental problems deserves special attention. Agroforestry development of territories is considered a recognized means of combating desertification. The article considers large-scale agroforestry projects initiated in the USA, the USSR, China, and African countries, development schemes, individual and common features of these projects, and stages of implementation. The authors emphasize that the experience of Russia in the field of agroforestry was actively used in foreign countries during the nineteenth and twentieth centuries, since the scientific achievements of Russian and Soviet scientists in the development of protective afforestation are recognized in the world.
土地荒漠化是最严重的环境问题之一,值得特别关注。发展农林业被认为是防治荒漠化的公认手段。文章探讨了美国、苏联、中国和非洲国家发起的大规模农林项目、发展计划、这些项目的个性和共性以及实施阶段。作者强调,十九世纪和二十世纪,俄罗斯在农林业领域的经验被外国积极借鉴,因为俄罗斯和苏联科学家在发展保护性造林方面的科学成就得到了世界的认可。
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引用次数: 0
External-beam neutron therapy: the first domestic medical unit 体外束中子疗法:国内首台医疗设备
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010098
Yury S. Mardynsky, I. Gulidov, K. B. Gordon, S. N. Кoryakin, А. N. Solovyov, V. Saburov, S. A. Ivanov, А. D. Kaprin, Т. K. Lobzhanidze, N. V. Маrkov, I. М. Zheleznov, D. Yurkov, О. A. Gerasimchuk, А. Y. Presnyakov, V. I. Zverev, V. P. Smirnov
Modern radiotherapy, employing traditional linear accelerators, has nearly reached its apex in terms of efficacy in treating oncological diseases. The challenge before researchers in the field of implementing cutting-edge technologies pertains to the utilization of fundamentally different therapeutic approaches, one of which is remote neutron therapy. Its salient advantages include an increased relative biological effectiveness of radiation, while the complexities of implementing specific technological solutions encompass forming a beam of the required geometry and spectral characteristics. The article delineates the key milestones in the development of the usage of fast neutron beams for remote radiotherapy, a general description of the neutron therapy complex and its primary structural components is also presented. These are currently being developed as an innovative, mass-producible medical project.
采用传统直线加速器的现代放射疗法在治疗肿瘤疾病方面的疗效几乎达到了顶峰。研究人员在实施尖端技术领域面临的挑战与利用根本不同的治疗方法有关,远程中子疗法就是其中之一。远程中子疗法的突出优势包括提高辐射的相对生物有效性,而实施特定技术解决方案的复杂性则包括形成所需的几何形状和光谱特征的光束。文章描述了利用快中子束进行远程放射治疗的重要里程碑,还介绍了中子治疗综合装置及其主要结构组件的总体情况。这些部件目前正在作为一个创新的、可大规模生产的医疗项目进行开发。
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引用次数: 0
Antibiotic resistance genes in pathogens of open cavities 开放性龋齿病原体中的抗生素耐药基因
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010055
S. Shabunin, G. Vostroilova, D. I. Shabanov, I. Burakova, Yu.D. Smirnova, M. Gryaznova, M. Syromyatnikov
The work is devoted to the study of the phenotypic and genotypic resistance to antibiotics of bacteria that cause diseases of open cavities of farm animals – mastitis and colibacteriosis. A high prevalence of antibiotic resistance genes of bacteria has been established, both in the gut of piglets and in the causative agents of cow mastitis. It is noteworthy that 38% of the identified genes in the gut microbiota were beta-lactam antibiotic resistance genes. It has been shown that all bacteria E. coli of piglets’ gut turned out to be phenotypically multiresistant. More than 88% of the causative agents of mastitis in cows were characterized by resistance to benzylpenicillin, ampicillin, lincomycin and polymyxin. At the same time, 19 varieties of antibiotic resistance genes have been identified in the causative agents of mastitis. The study of phenotypic resistance to antibiotics and the genome of pathogens of farm animals did not reveal stable correlations between them. It is necessary to conduct further active research in the field of circulation of resistance genes in livestock farms for the safety of livestock.
这项工作致力于研究引起农场动物开放性空腔疾病--乳腺炎和大肠杆菌病--的细菌对抗生素的表型和基因型耐药性。无论是在仔猪肠道中还是在奶牛乳腺炎的致病菌中,细菌的抗生素耐药性基因的流行率都很高。值得注意的是,在肠道微生物群中发现的基因中,有 38% 是β-内酰胺类抗生素耐药基因。研究表明,仔猪肠道中的所有大肠杆菌在表型上都具有多重耐药性。88% 以上的奶牛乳腺炎致病菌对苄青霉素、氨苄西林、林可霉素和多粘菌素具有耐药性。同时,在乳腺炎致病菌中还发现了 19 种抗生素耐药基因。对抗生素表型耐药性和农场动物病原体基因组的研究并未发现两者之间存在稳定的相关性。为了牲畜的安全,有必要进一步积极研究抗药性基因在畜牧场中的流通情况。
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引用次数: 0
Two circuit assessments of the performance of scientific organizations in Russia: current state and development prospects from the point of view of international experience 对俄罗斯科学组织绩效的两次巡回评估:从国际经验角度看现状和发展前景
Pub Date : 2024-07-04 DOI: 10.31857/s0869587324010063
D. V. Kosyakov, I. V. Selivanova, A. Guskov
In Russia, in fact, two contours for assessing the scientific performance of organizations have developed: the expert one, which underlies the categorization of scientific organizations, and the quantitative one, which, according to the methodology of the comprehensive calculation of publication productivity, makes it possible to determine and monitor the implementation of the state assignment for fundamental scientific research. The article describes the history of the formation of these circuits, their advantages and disadvantages, as well as the prerequisites for further development. The British REF (Research Excellence Framework) examination system and the Norwegian quantitative assessment model are considered as model examples for improving both circuits. REF features include a differentiated assessment of the results, impact and environment of scientific units, which is organized by expert panels and groups. The features of the Norwegian model are an expert approach to the formation of a national white list of scientific journals, conferences and publishers, a methodology for calculating the publication indicator and an open database of publications of Norwegian scientists, from which this indicator is determined. The authors believe that these two examples can be considered as parametric assessment models, the adaptation of which taking into account national characteristics will make it possible to update and improve both contours of the assessment of scientific organizations in Russia. The importance of regular retrospective reflection on the experience, procedures and results of assessing organizations is emphasized, which is necessary for the systematic development of this system at the next stages.
事实上,在俄罗斯已经形成了两种评估科研组织科学绩效的方法:一种是专家方法,它是科研组织分类的基础;另一种是定量方法,它根据出版生产力综合计算方法,可以确定和监督国家基础科学研究任务的执行情况。文章介绍了这些回路的形成历史、优缺点以及进一步发展的前提条件。英国的REF(卓越研究框架)考试制度和挪威的量化评估模式被视为改进这两个系统的范例。REF 的特点包括由专家小组和专家组对科研单位的成果、影响和环境进行有区别的评估。挪威模式的特点是以专家方法编制国家科学期刊、会议和出版商白名单,计算出版指标的方法,以及据以确定该指标的挪威科学家出版物开放数据库。作者认为,这两个例子可被视为参数评估模型,根据本国特点对其进行调整,将有可能更新和完善俄罗斯科学组织评估的两个轮廓。作者强调了定期回顾反思评估组织的经验、程序和结果的重要性,这对于该系统在下一 阶段的系统化发展十分必要。
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引用次数: 0
Идеи академика А.Д. Сахарова и стратегическая стабильность
Pub Date : 2022-07-01 DOI: 10.31857/s0869587321120033
Алексей Георгиевич Арбатов
Начало специальной операции России на Украине в конце февраля 2022 г. ознаменовало окончание исторического периода более полувека длиной. Отношения СССР/России и Запада завершили полный круг и вернулись к холодной войне, вновь приблизив державы к роковой черте, едва не перейденной в дни Карибского кризиса октября 1962 г. Влияние украинского конфликта на стратегическую стабильность проявляется, во-первых, в новых взглядах на ядерное сдерживание. Видимо, теперь в качестве причин рассмотрения вопроса применения российских ядерных сил подразумевается не только нападение на Россию и ее союзников с использованием ядерного или обычного оружия, но и прямое вовлечение НАТО в локальные военные действия на территории Украины, оказание ей помощи поставками вооружений, экономические санкции и даже агрессивные высказывания против России. На Западе эта тема широко обсуждается, в том числе на правительственном уровне, несмотря на официальные заявления Москвы об отсутствии таких ядерных планов. Во-вторых, воздействие украинской трагедии на стратегическую стабильность в том, что она непосредственно отразилась на переговорах России и США по стратегическим вооружениям, которые опять оказались “заморожены” после успешного дебюта в июле 2021 г. в Женеве. В-третьих, текущий конфликт пагубно отразился на общем климате политических отношений государств в Европе и за ее пределами, что всегда было важным фоном переговоров по контролю над вооружениями. Если удастся избежать наихудшего сценария, то рано или поздно украинская проблема будет разрешена мирным путем, каким бы трудным и далеким ни казался сейчас такой итог. После этого, или даже в процессе продвижения к миру, возможно возобновление диалога России и США по контролю над вооружениями. Так бывало и в прошлом, начиная с ослабления напряженности после Карибского кризиса и подписания договора 1963 г. о частичном запрещении ядерных испытаний. Затем, разрешая периодические кризисы, ответственные державы заключили десятки договоров по ядерному оружию и другим смертоносным средствам, что позволило к концу 1980-х годов завершить холодную войну, свернуть гонку вооружений и на три десятилетия избавить мир от призрака ядерного Армагеддона.
2022年2月底,俄罗斯在乌克兰开始了一项特别行动,标志着半个多世纪历史的结束。苏联/俄罗斯和西方的关系完成了一个完整的循环,又回到了冷战,再次接近于1962年10月加勒比海危机期间几乎跨越的临界点。乌克兰冲突对战略稳定的影响首先体现在对核威慑的新观点上。可见,现在作为理由审议俄罗斯核使用武力不仅意味着袭击俄罗斯使用核武器或常规武器及其盟友,但局部军事行动和北约直接介入乌克兰领土上她援助武器供应,对俄罗斯的经济制裁,甚至攻击性言论。在西方,这个话题被广泛讨论,包括在政府层面,尽管莫斯科官方宣称没有这样的核计划。其次,乌克兰悲剧对战略稳定的影响直接影响到俄罗斯和美国在2021年7月在日内瓦成功登场后再次“冻结”的战略武器谈判。第三,当前的冲突严重影响了欧洲和其他国家政治关系的总体气候,这一直是军备控制谈判的重要背景。如果避免了最坏的情况,乌克兰问题迟早会以和平的方式得到解决,不管结果现在看起来多么困难和遥远。在那之后,甚至在走向和平的过程中,俄罗斯和美国的军备控制对话可能会重新开始。自古巴导弹危机后局势缓和和1963年签署《部分禁止核试验条约》以来,这种情况一直在发生。然后,在解决定期危机的过程中,负责任的大国签署了数十项核武器和其他致命武器条约,使冷战在20世纪80年代末结束,军备竞赛结束,使世界摆脱核世界末日的幽灵长达30年。
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引用次数: 0
Science’s role in socioeconomic development of integrated scientific and technological space of the union state of Russia and Belarus 科学在俄白联盟国家一体化科技空间社会经济发展中的作用
Pub Date : 2019-11-13 DOI: 10.31857/s0869-587389111085-1094
G. Zaikina, Г А Заикина
On June 18, 2019, the Presidiums of the Russian Academy of Sciences and of the National Academy of Sciences of Belarus held a joint session to discuss results of cooperation in 2018, prospective projects of Union State programs, and short-term plans for cooperation between the Russian Academy of Sciences and the National Academy of Sciences of Belarus. Particular attention was paid to scientific support for development of strategic directions for long-term spatial-territorial and socioeconomic development of Russia and Belarus and to the concept of the United Eurasia megaproject.
2019年6月18日,俄罗斯科学院和白俄罗斯国家科学院主席团举行了联合会议,讨论了2018年的合作成果、联盟国家计划的预期项目以及俄罗斯科学院和白俄罗斯国家科学院的短期合作计划。双方特别关注为制定俄罗斯和白俄罗斯长期空间-领土和社会经济发展战略方向提供科学支持,以及欧亚联合大项目的概念。
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引用次数: 0
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Вестник Российской академии наук
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