Pub Date : 2023-04-20DOI: 10.17650/2686-9594-2023-13-1-39-44
M. N. Saryev, M. B. Nurberdyev, R. Valiev, M. Nechushkin, E. A. Tizilova, A. S. Tikhomirova, V. Aliev
One of the possible adverse events of cervical cancer arising both as a result of the progression of the disease and as a result of the treatment, leading to a significant decrease in the quality of life, is the development of genital fistulas. This review presents current information on diagnostic approaches, and treatment options for fistulas caused by cervical cancer. The peculiarities of fistulas that have arisen after radiation therapy and surgical treatment are highlighted.
{"title":"Fistulas as a complication of cervical cancer: the current state of the problem","authors":"M. N. Saryev, M. B. Nurberdyev, R. Valiev, M. Nechushkin, E. A. Tizilova, A. S. Tikhomirova, V. Aliev","doi":"10.17650/2686-9594-2023-13-1-39-44","DOIUrl":"https://doi.org/10.17650/2686-9594-2023-13-1-39-44","url":null,"abstract":"One of the possible adverse events of cervical cancer arising both as a result of the progression of the disease and as a result of the treatment, leading to a significant decrease in the quality of life, is the development of genital fistulas. This review presents current information on diagnostic approaches, and treatment options for fistulas caused by cervical cancer. The peculiarities of fistulas that have arisen after radiation therapy and surgical treatment are highlighted.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47283455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-20DOI: 10.17650/2686-9594-2023-13-1-27-32
S. Y. Trishchenkov, D. Erygin, A. Nevolskikh, L. Petrov, T. P. Pochujev, Yu. Yu. Mikhalevа, I. A. Orekhov, D. T. Mouraova, M. D. Sivolob
Purpose of the study. To study the frequency and risk factors for the development of colorectal anastomosis leakage after anterior rectal resection for cancer.Materials and Methods. In a retrospective cohort study between April 2011 and February 2018. The data of the case histories of patients who underwent combined treatment for rectal cancer were analyzed. The study included patients who underwent neoadjuvant chemoradiotherapy followed by surgery. The influence of risk factors on the incidence of AN was assessed based on multivariate analysis using the logistic regression method.Results. The study was conducted in 474 patients who underwent anterior resection for rectal cancer. Depending on the outcome of the operation, the patients were divided into two groups: with the formation of a preventive intestinal stoma (main group, n = 344) and without formation (control group, n = 140) The overall incidence of postoperative complications was 20.6 % in patients with preventive stoma (PS) and 26.1 % without PS (p = 0.198). Colorectal anastomosis (RCA) leaks were detected in 40 (11.6 %) patients in the PS group and in 9 (6.9 %) patients in the non-PS group (р = 0,134). This complication was detected on the 7th day (2–12 days) after the operation in 5 (9.8 %) patients, while in patients with PS on the 10th day (11.6 %) and without PS on 3 (6.9 %) %), (p = 0.134). According to the classification of NCA severity, grade A was detected in 12 patients, B – at 24, C – in 11 patients. The frequency of reoperations in patients with PS was 10.8 %, while in patients with PS it was 15 % (p <0.001). The most common reason for reoperations in patients with LCA in the group without PS was the development of peritonitis (5.4 %, p <0.001). In a statistical multivariate analysis, the most significant risk factors for the development of NCA were: the presence of preoperative chemoradiotherapy (p = 0.001), diabetes mellitus (p = 0.031) and stage III–IV of the disease (p = 0.051).Conclusions. The formation of a preventive intestinal stoma after anterior resections does not reduce the incidence of colorectal anastomosis leaks (p = 0.134), however, it reduces the degree of manifestation of AN in the severity of the course of the postoperative postoperative period (p = 0.029). The frequency of reoperations in patients without a PS is significantly higher than in patients with a stoma (p <0.0001). Diabetes mellitus, chemoradiotherapy, and stage III–IV of the disease are factors influencing the development of leakage.
{"title":"Colorectal anastomosis leakage after anterior rectal resection: frequency, risk factors","authors":"S. Y. Trishchenkov, D. Erygin, A. Nevolskikh, L. Petrov, T. P. Pochujev, Yu. Yu. Mikhalevа, I. A. Orekhov, D. T. Mouraova, M. D. Sivolob","doi":"10.17650/2686-9594-2023-13-1-27-32","DOIUrl":"https://doi.org/10.17650/2686-9594-2023-13-1-27-32","url":null,"abstract":"Purpose of the study. To study the frequency and risk factors for the development of colorectal anastomosis leakage after anterior rectal resection for cancer.Materials and Methods. In a retrospective cohort study between April 2011 and February 2018. The data of the case histories of patients who underwent combined treatment for rectal cancer were analyzed. The study included patients who underwent neoadjuvant chemoradiotherapy followed by surgery. The influence of risk factors on the incidence of AN was assessed based on multivariate analysis using the logistic regression method.Results. The study was conducted in 474 patients who underwent anterior resection for rectal cancer. Depending on the outcome of the operation, the patients were divided into two groups: with the formation of a preventive intestinal stoma (main group, n = 344) and without formation (control group, n = 140) The overall incidence of postoperative complications was 20.6 % in patients with preventive stoma (PS) and 26.1 % without PS (p = 0.198). Colorectal anastomosis (RCA) leaks were detected in 40 (11.6 %) patients in the PS group and in 9 (6.9 %) patients in the non-PS group (р = 0,134). This complication was detected on the 7th day (2–12 days) after the operation in 5 (9.8 %) patients, while in patients with PS on the 10th day (11.6 %) and without PS on 3 (6.9 %) %), (p = 0.134). According to the classification of NCA severity, grade A was detected in 12 patients, B – at 24, C – in 11 patients. The frequency of reoperations in patients with PS was 10.8 %, while in patients with PS it was 15 % (p <0.001). The most common reason for reoperations in patients with LCA in the group without PS was the development of peritonitis (5.4 %, p <0.001). In a statistical multivariate analysis, the most significant risk factors for the development of NCA were: the presence of preoperative chemoradiotherapy (p = 0.001), diabetes mellitus (p = 0.031) and stage III–IV of the disease (p = 0.051).Conclusions. The formation of a preventive intestinal stoma after anterior resections does not reduce the incidence of colorectal anastomosis leaks (p = 0.134), however, it reduces the degree of manifestation of AN in the severity of the course of the postoperative postoperative period (p = 0.029). The frequency of reoperations in patients without a PS is significantly higher than in patients with a stoma (p <0.0001). Diabetes mellitus, chemoradiotherapy, and stage III–IV of the disease are factors influencing the development of leakage.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46379404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-20DOI: 10.17650/2686-9594-2023-13-1-33-38
I. V. Kozlova, Y. Udalov, L. A. Danilova, A. Nezvetsky, I. A. Bogomolova, S. E. Gritsenko
Colorectal cancer is a significant group of malignant neoplasms that dominates the morbidity and mortality patterns in the world. for patients with colorectal cancer, a multidisciplinary approach is required when choosing treatment tactics involving surgeons, radiotherapists and chemotherapists. At present, it is impossible to overestimate the role of radiotherapy in the treatment of locally advanced rectal cancer. The purpose of this review is to summarize current data on proton beam therapy and its role in the treatment of rectal cancer.
{"title":"Proton beam therapy for rectal cancer: a literature review","authors":"I. V. Kozlova, Y. Udalov, L. A. Danilova, A. Nezvetsky, I. A. Bogomolova, S. E. Gritsenko","doi":"10.17650/2686-9594-2023-13-1-33-38","DOIUrl":"https://doi.org/10.17650/2686-9594-2023-13-1-33-38","url":null,"abstract":"Colorectal cancer is a significant group of malignant neoplasms that dominates the morbidity and mortality patterns in the world. for patients with colorectal cancer, a multidisciplinary approach is required when choosing treatment tactics involving surgeons, radiotherapists and chemotherapists. At present, it is impossible to overestimate the role of radiotherapy in the treatment of locally advanced rectal cancer. The purpose of this review is to summarize current data on proton beam therapy and its role in the treatment of rectal cancer.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42940148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-20DOI: 10.17650/2686-9594-2023-13-1-11-18
O. A. Rozonova, N. A. Kozlov, A. Y. Volkov, A. Egorova, E. V. Artamonovа
Background. Uterine leiomyosarcomas are highly aggressive tumors with a poor prognosis. The main prognostic factors are the stage of the disease, the size of the primary tumor, and the grade of malignancy. It is well known that the clinical course and prognosis of uterine leiomyosarcoma do not correlate with the FNCLCC histological grade, based on assessment of the mitotic index and the presence and amount of necrosis in sarcomas. There is published data on a more unfavorable course of non-spindle cell uterine leiomyosarcomas.Aim. To evaluate the influence of pathological factors (histological subtype, mitotic index, necrosis and its type) on survival rates in uterine leiomyosarcoma.Materials and methods. The study included 58 patients who underwent radical surgery for uterine leiomyosarcoma. The following morphological parameters were evaluated on histological slides: histological subtype, mitotic index, the presence of necrosis in the tumor and its type. Further, the analysis of the influence of these morphological characteristics on the indicators of progression-free survival and overall survival was carried out. Statistical analysis was carried out using the IBM SPSS Statistics Professional 20.0 statistical software package. Long-term results are presented in the form of actuarial survival calculated by the Kaplan–Meier method.Results. Most cases of uterine leiomyosarcoma were of the spindle-cell variant (82.8 %), had a mitotic index >20 per 10 high power field (93.1 %) and large foci of necrosis (70.7 %), coagulation necrosis was more often detected (43.1 %). There was a significant difference in the median overall survival of patients with spindle-cell variant of uterine leiomyosarcoma and non-spindle-cell variants (epithelioid or myxoid): 77 months vs. 49 months (p = 0.05). There was no significant relationship between the mitotic index of the primary tumor, the size of necrosis foci in the tumor and survival rates. The presence of coagulative necrosis in the tumor was significantly associated with a deterioration in progression-free survival (9 months vs. 14 months, p = 0.05) and overall survival (51 months vs. 104 months, p = 0.05).Conclusion. The spindle-cell variant of leiomyosarcoma is associated with higher overall survival rates compared to other histological subtypes. The presence of coagulative necrosis in the tumor in comparison with other types of necrosis is an unfavorable prognostic factor associated with a decrease in both progression-free survival and overall survival.
背景子宫平滑肌肉瘤是高度侵袭性肿瘤，预后不良。主要的预后因素是疾病的分期、原发肿瘤的大小和恶性程度。众所周知，子宫平滑肌肉瘤的临床病程和预后与FNCLCC的组织学分级无关，这是基于对有丝分裂指数以及肉瘤中坏死的存在和数量的评估。有关于非梭形细胞子宫平滑肌肉瘤更不利的过程的公开数据。目标评估病理因素（组织学亚型、有丝分裂指数、坏死及其类型）对子宫平滑肌肉瘤生存率的影响。材料和方法。该研究包括58名接受子宫平滑肌肉瘤根治性手术的患者。在组织学切片上评估以下形态学参数：组织学亚型、有丝分裂指数、肿瘤坏死的存在及其类型。此外，还分析了这些形态学特征对无进展生存率和总生存率指标的影响。使用IBM SPSS Statistics Professional 20.0统计软件包进行统计分析。长期结果以Kaplan–Meier方法计算的精算生存率的形式呈现。后果大多数子宫平滑肌肉瘤为梭形细胞变体（82.8%），有丝分裂指数>20/10高倍视野（93.1%）和大坏死灶（70.7%），凝固性坏死更常见（43.1%）。子宫平滑肌肉瘤梭形细胞变异和非梭形细胞（上皮样或黏液样）变异患者的中位总生存期存在显著差异：77个月与49个月（p=0.05）。原发肿瘤的有丝分裂指数、肿瘤坏死灶的大小与生存率之间无显著关系。肿瘤中存在凝固性坏死与无进展生存期（9个月对14个月，p=0.05）和总生存期（51个月对104个月，p=0.05）的恶化显著相关。结论：与其他组织学亚型相比，平滑肌肉瘤的梭形细胞变体与更高的总生存率相关。与其他类型的坏死相比，肿瘤中存在凝固性坏死是一个不利的预后因素，与无进展生存期和总生存期的降低有关。
{"title":"Morphological parameters of uterine body leiomyosarcoma associated with survival rates","authors":"O. A. Rozonova, N. A. Kozlov, A. Y. Volkov, A. Egorova, E. V. Artamonovа","doi":"10.17650/2686-9594-2023-13-1-11-18","DOIUrl":"https://doi.org/10.17650/2686-9594-2023-13-1-11-18","url":null,"abstract":"Background. Uterine leiomyosarcomas are highly aggressive tumors with a poor prognosis. The main prognostic factors are the stage of the disease, the size of the primary tumor, and the grade of malignancy. It is well known that the clinical course and prognosis of uterine leiomyosarcoma do not correlate with the FNCLCC histological grade, based on assessment of the mitotic index and the presence and amount of necrosis in sarcomas. There is published data on a more unfavorable course of non-spindle cell uterine leiomyosarcomas.Aim. To evaluate the influence of pathological factors (histological subtype, mitotic index, necrosis and its type) on survival rates in uterine leiomyosarcoma.Materials and methods. The study included 58 patients who underwent radical surgery for uterine leiomyosarcoma. The following morphological parameters were evaluated on histological slides: histological subtype, mitotic index, the presence of necrosis in the tumor and its type. Further, the analysis of the influence of these morphological characteristics on the indicators of progression-free survival and overall survival was carried out. Statistical analysis was carried out using the IBM SPSS Statistics Professional 20.0 statistical software package. Long-term results are presented in the form of actuarial survival calculated by the Kaplan–Meier method.Results. Most cases of uterine leiomyosarcoma were of the spindle-cell variant (82.8 %), had a mitotic index >20 per 10 high power field (93.1 %) and large foci of necrosis (70.7 %), coagulation necrosis was more often detected (43.1 %). There was a significant difference in the median overall survival of patients with spindle-cell variant of uterine leiomyosarcoma and non-spindle-cell variants (epithelioid or myxoid): 77 months vs. 49 months (p = 0.05). There was no significant relationship between the mitotic index of the primary tumor, the size of necrosis foci in the tumor and survival rates. The presence of coagulative necrosis in the tumor was significantly associated with a deterioration in progression-free survival (9 months vs. 14 months, p = 0.05) and overall survival (51 months vs. 104 months, p = 0.05).Conclusion. The spindle-cell variant of leiomyosarcoma is associated with higher overall survival rates compared to other histological subtypes. The presence of coagulative necrosis in the tumor in comparison with other types of necrosis is an unfavorable prognostic factor associated with a decrease in both progression-free survival and overall survival.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49418096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.17650/2686-9594-2022-12-4-33-40
I. V. Matveev, M. Danilov, A. V. Klimashevich, A. Allakhverdiev, A. Leontyev, A. Baychorov, Z. Abdulatipova, A. V. Maksimenko
{"title":"Optimized surgical tactics for localized colon cancer (literature review)","authors":"I. V. Matveev, M. Danilov, A. V. Klimashevich, A. Allakhverdiev, A. Leontyev, A. Baychorov, Z. Abdulatipova, A. V. Maksimenko","doi":"10.17650/2686-9594-2022-12-4-33-40","DOIUrl":"https://doi.org/10.17650/2686-9594-2022-12-4-33-40","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47869985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.17650/2686-9594-2022-12-4-52-59
A. Shabunin, D. Grekov, Z. A. Bagateliya, V. M. Kulushev, N. Sokolov, A. Minenkova, S. S. Lebedev, M. S. Lebedko
{"title":"Perioperative chemotherapy in the treatment of locally advanced forms of colon cancer: literature review","authors":"A. Shabunin, D. Grekov, Z. A. Bagateliya, V. M. Kulushev, N. Sokolov, A. Minenkova, S. S. Lebedev, M. S. Lebedko","doi":"10.17650/2686-9594-2022-12-4-52-59","DOIUrl":"https://doi.org/10.17650/2686-9594-2022-12-4-52-59","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46407859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.17650/2686-9594-2022-12-4-26-32
B. Akhmedov
{"title":"Prediction factors in surgical treatment of intragrawn kidney cancer metastasis","authors":"B. Akhmedov","doi":"10.17650/2686-9594-2022-12-4-26-32","DOIUrl":"https://doi.org/10.17650/2686-9594-2022-12-4-26-32","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41461942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.17650/2686-9594-2022-12-4-11-18
S. Gordeev, E. Rybakov, A. M. Каrachun, V. B. Кaushanskiy, K. A. Tsapko, D. Samsonov, Z. Z. Маmedli, I. Stilidi
{"title":"The optimal surgical volume for anorectal melanoma: a retrospective analysis of the Russian Colorectal Cancer Society registry","authors":"S. Gordeev, E. Rybakov, A. M. Каrachun, V. B. Кaushanskiy, K. A. Tsapko, D. Samsonov, Z. Z. Маmedli, I. Stilidi","doi":"10.17650/2686-9594-2022-12-4-11-18","DOIUrl":"https://doi.org/10.17650/2686-9594-2022-12-4-11-18","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47851854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.17650/2686-9594-2022-12-4-19-25
B. Akhmedov
{"title":"Short-term and long-term outcomes of repeated surgeries for lung metastases","authors":"B. Akhmedov","doi":"10.17650/2686-9594-2022-12-4-19-25","DOIUrl":"https://doi.org/10.17650/2686-9594-2022-12-4-19-25","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46900438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.17650/2686-9594-2022-12-4-41-51
M. Fedyanin
{"title":"Cabozantinib in hepatocellular cancer: from preclinical experiments to observational studies","authors":"M. Fedyanin","doi":"10.17650/2686-9594-2022-12-4-41-51","DOIUrl":"https://doi.org/10.17650/2686-9594-2022-12-4-41-51","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46998299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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