Pub Date : 2019-11-13DOI: 10.17650/2686-9594-2019-9-4-11-20
B. Belotserkovskiy, E. Gelfand, A. Bykov, O. Mamontova, D. Protsenko
This review focuses on the practical aspects of prevention and treatment of fungal infections in surgical patients. It covers epidemiology and risk factors for invasive candidiasis, updates on the etiological structure of fungal infections in patients in critical conditions, and provides the information on drug sensitivity of Candida species. The authors discuss the limitations of cultural and non-cultural diagnostic methods used in invasive candidiasis, emphasizing the importance of analyzing the existing risk factors in combination with a comprehensive assessment of clinical and laboratory data for timely initiation of adequate antifungal therapy. The review provides a brief description of currently available antimicotics, including polyenes, triazoles, and echinocandins. It also describes the benefits of anidulafungin, which does not interact with other drugs and has no negative effect on the liver and kidney. The article also covers indications for antifungal agents in surgical intensive care units in accordance with international and Russian guidelines. A cohort of patients with abdominal diseases requiring preventive and empirical treatment with antimicotics is described. In additions to that, the manuscript contains a rationale for the use of echinocandins in targeted therapy of invasive candidiasis.
{"title":"Criteria for the administration of systemic antimicotic therapy in surgical intensive care units (literature review)","authors":"B. Belotserkovskiy, E. Gelfand, A. Bykov, O. Mamontova, D. Protsenko","doi":"10.17650/2686-9594-2019-9-4-11-20","DOIUrl":"https://doi.org/10.17650/2686-9594-2019-9-4-11-20","url":null,"abstract":"This review focuses on the practical aspects of prevention and treatment of fungal infections in surgical patients. It covers epidemiology and risk factors for invasive candidiasis, updates on the etiological structure of fungal infections in patients in critical conditions, and provides the information on drug sensitivity of Candida species. The authors discuss the limitations of cultural and non-cultural diagnostic methods used in invasive candidiasis, emphasizing the importance of analyzing the existing risk factors in combination with a comprehensive assessment of clinical and laboratory data for timely initiation of adequate antifungal therapy. The review provides a brief description of currently available antimicotics, including polyenes, triazoles, and echinocandins. It also describes the benefits of anidulafungin, which does not interact with other drugs and has no negative effect on the liver and kidney. The article also covers indications for antifungal agents in surgical intensive care units in accordance with international and Russian guidelines. A cohort of patients with abdominal diseases requiring preventive and empirical treatment with antimicotics is described. In additions to that, the manuscript contains a rationale for the use of echinocandins in targeted therapy of invasive candidiasis.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67787520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-13DOI: 10.17650/2686-9594-2019-9-4-48-56
S. Tkachev, A. Abduzhapparov, V. Aliev, Y. Barsukov, J. Madyarov
This article demonstrates the experience of successful treatment of a patient with locally advanced rectal cancer, who received a combined treatment with a non-standard course of chemoradiotherapy in hypofractionation mode according to a prolonged program. After the end of a course of chemoradiation received the complete clinical response of the tumor.
{"title":"Neoadjuvant chemoradiation therapy for locally advanced colorectal cancer in hypofractionation mode (case report)","authors":"S. Tkachev, A. Abduzhapparov, V. Aliev, Y. Barsukov, J. Madyarov","doi":"10.17650/2686-9594-2019-9-4-48-56","DOIUrl":"https://doi.org/10.17650/2686-9594-2019-9-4-48-56","url":null,"abstract":"This article demonstrates the experience of successful treatment of a patient with locally advanced rectal cancer, who received a combined treatment with a non-standard course of chemoradiotherapy in hypofractionation mode according to a prolonged program. After the end of a course of chemoradiation received the complete clinical response of the tumor.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67787154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-13DOI: 10.17650/2686-9594-2019-9-4-32-36
O. Kozhevnikova, S. A. Nikogosyan, V. S. Ananyev, V. V. Kyznetsov, A. S. Shevchuk
Objective: to analyze intraoperative and postoperative complications in patients who underwent combination surgeries for advanced ovarian cancer. Materials and methods . This retrospective study included patients that underwent primary or interval cytoreductive combination surgeries for advanced (grade III–IV) ovarian cancer at N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia between 2000 and 2017. Results . We analyzed medical records of 144 patients with grade III–IV ovarian cancer who underwent combination surgery at some stage of their treatment. Almost two-thirds of patients (64.8 %) had complete or optimal volume of surgery. Intraoperative complications were registered in 7 % of patients (n = 10), while postoperative complications were observed in 38.2 % of cases (n = 55). The postoperative death rate was 0.7 % (n = 1). Conclusions . Higher frequency of complete and optimal cytoreduction, as well as acceptable level of intra- and postoperative complications confirm the need for combination surgeries in patients with advanced ovarian cancer. Aggressive surgical tactics should be used only in specialized cancer hospitals with the involvement of a multidisciplinary team that includes cancer surgeons and anesthesiologists in order to improve both short-term and long-term treatment outcomes in patients with advanced ovarian cancer.
{"title":"The immediate results of combined operations in patients with advanced ovarian cancer: the experience of N. N. Blokhin National Medical research Center of Oncology, Ministry of health of russia","authors":"O. Kozhevnikova, S. A. Nikogosyan, V. S. Ananyev, V. V. Kyznetsov, A. S. Shevchuk","doi":"10.17650/2686-9594-2019-9-4-32-36","DOIUrl":"https://doi.org/10.17650/2686-9594-2019-9-4-32-36","url":null,"abstract":"Objective: to analyze intraoperative and postoperative complications in patients who underwent combination surgeries for advanced ovarian cancer. Materials and methods . This retrospective study included patients that underwent primary or interval cytoreductive combination surgeries for advanced (grade III–IV) ovarian cancer at N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia between 2000 and 2017. Results . We analyzed medical records of 144 patients with grade III–IV ovarian cancer who underwent combination surgery at some stage of their treatment. Almost two-thirds of patients (64.8 %) had complete or optimal volume of surgery. Intraoperative complications were registered in 7 % of patients (n = 10), while postoperative complications were observed in 38.2 % of cases (n = 55). The postoperative death rate was 0.7 % (n = 1). Conclusions . Higher frequency of complete and optimal cytoreduction, as well as acceptable level of intra- and postoperative complications confirm the need for combination surgeries in patients with advanced ovarian cancer. Aggressive surgical tactics should be used only in specialized cancer hospitals with the involvement of a multidisciplinary team that includes cancer surgeons and anesthesiologists in order to improve both short-term and long-term treatment outcomes in patients with advanced ovarian cancer.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67787663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-02DOI: 10.17650/2220-3478-2019-9-3-59-61
O. Malikhova, I. Karasev, V. Lozovaya, V. Vereshchak
{"title":"Endoscopic diagnosis and treatment of a patient with synchronous rectal neuroendocrine tumors (a case report)","authors":"O. Malikhova, I. Karasev, V. Lozovaya, V. Vereshchak","doi":"10.17650/2220-3478-2019-9-3-59-61","DOIUrl":"https://doi.org/10.17650/2220-3478-2019-9-3-59-61","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67773842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-02DOI: 10.17650/2686-9594-2019-9-3-54-58
Yu. N. Kolbashova, D. V. Aphanasyev, S. Y. Philosophov, V. Burtsev
{"title":"Buschke-Lowenstein tumor: a case report","authors":"Yu. N. Kolbashova, D. V. Aphanasyev, S. Y. Philosophov, V. Burtsev","doi":"10.17650/2686-9594-2019-9-3-54-58","DOIUrl":"https://doi.org/10.17650/2686-9594-2019-9-3-54-58","url":null,"abstract":"","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49213679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-02DOI: 10.17650/2686-9594-2019-9-3-34-45
Y. Barsukov, S. Tkachev, Z. Mamedli, S. Gordeev, A. Perevoshchikov, N. Oltarzhevskaya, O. Vlasov, V. Aliev, M. Korovina
Objective: to improve the outcomes of combination treatment of patients with rectal cancer using polyradiomodification and short courses of neoadjuvant radiotherapy. with polyradiomodification included a course of radiotherapy with a total dose of 25 Gy delivered in 5 fractions (5 Gy each), rectal administration of biopolymer composition containing metronidazole at a dose of 10 g/m 2 (5-h exposure in the rectum on days 3 and 5), and chemo-therapy with capecitabine at a dose of 2 g/m 2 on days 1–14 followed by surgery within the next 4–6 weeks. We analyzed the incidence of postoperative complications, 5-year relapse-free survival, and frequency of relapses. Results. The incidence of grade IIIB postoperative complications was significantly lower in patients who underwent combination treatment with polyradiomodification than in those who had surgery only (p = 0.0023) and those who had combination therapy without polyradiomodification (p = 0.0003). The 5-year relapse-free survival rate was 80.5 % in the group of CT + PRM compared to 64.9 % in the group of CT (p = 0.00315) and 60.1 % in the group of ST (p = 0.000001). The frequency of relapses was 0.4 %, 8.5 % (p = 0.00001), and 13.7 % (p = 0.00001) in the groups CT + PRM, CT, and ST respectively. There were no significant differences in the incidence of distant metastasis between the groups. Conclusions. The developed variant of combination treatment with polyradiomodification did not increase the number of complications and ensured better relapse-free survival due to improved locoregional control.
{"title":"Combination treatment of rectal cancer using polyradiomodification and short courses of neoadjuvant radiotherapy","authors":"Y. Barsukov, S. Tkachev, Z. Mamedli, S. Gordeev, A. Perevoshchikov, N. Oltarzhevskaya, O. Vlasov, V. Aliev, M. Korovina","doi":"10.17650/2686-9594-2019-9-3-34-45","DOIUrl":"https://doi.org/10.17650/2686-9594-2019-9-3-34-45","url":null,"abstract":"Objective: to improve the outcomes of combination treatment of patients with rectal cancer using polyradiomodification and short courses of neoadjuvant radiotherapy. with polyradiomodification included a course of radiotherapy with a total dose of 25 Gy delivered in 5 fractions (5 Gy each), rectal administration of biopolymer composition containing metronidazole at a dose of 10 g/m 2 (5-h exposure in the rectum on days 3 and 5), and chemo-therapy with capecitabine at a dose of 2 g/m 2 on days 1–14 followed by surgery within the next 4–6 weeks. We analyzed the incidence of postoperative complications, 5-year relapse-free survival, and frequency of relapses. Results. The incidence of grade IIIB postoperative complications was significantly lower in patients who underwent combination treatment with polyradiomodification than in those who had surgery only (p = 0.0023) and those who had combination therapy without polyradiomodification (p = 0.0003). The 5-year relapse-free survival rate was 80.5 % in the group of CT + PRM compared to 64.9 % in the group of CT (p = 0.00315) and 60.1 % in the group of ST (p = 0.000001). The frequency of relapses was 0.4 %, 8.5 % (p = 0.00001), and 13.7 % (p = 0.00001) in the groups CT + PRM, CT, and ST respectively. There were no significant differences in the incidence of distant metastasis between the groups. Conclusions. The developed variant of combination treatment with polyradiomodification did not increase the number of complications and ensured better relapse-free survival due to improved locoregional control.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67787348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-02DOI: 10.17650/2686-9594-2019-9-3-46-53
M. N. Sekerskaya, S. Nikogosyan, V. Kuznetsov, A. S. Shevchuk, R. Tamrazov, V. Aliev
Background . Comparative assessment of the long-term oncological results of extended, combined and standard surgical interventions. Materials and methods . The study included women with histologically verified ovarian cancer T3—4N0—1M0—1. Group A (experimental) patients underwent advanced and combined surgical interventions; group B (control) patients underwent standard surgical interventions. In the postoperative period, all patients received 6 courses of polychemotherapy with a combination of platinum and taxanes. The authors compared the frequency of achieving optimal and conditionally radical operations after performing extended and combined operations and standard surgical interventions, the structure, frequency and causes of intra- and postoperative complications, and overall and disease-free survival. Results . From 2010 to 2018, we selected 150 archived case histories of patients with advanced ovarian cancer (III-IV stages). 135 (90 %) patients were able to track the long-term results of treatment. In group A (experimental), complete debulking was achieved in 52.8 %, in group B (control) — 26.7 %. In group A, 6 (19.9 %) patients had postoperative complications of I-II degree of severity, 1 patient had postoperative complications of IIIA degree of severity, complications of IIIB-IV degree of severity in the study group did not occur (p = 0.05). In group B, intraoperative complications were observed in 27 (22.5 %) patients. Postoperative I—II degrees of severity were observed in 28 (23.3 %) patients, III—IV degrees of severity — in 8 (6.6 %). In group B, the overall survival rate was 54.7 months, and re¬lapse-free was 14.3 months, in group A — 79.2 months and 19 months respectively (p = 0.004 and <0.05). Conclusions . The method of choosing treatment for patients with advanced ovarian cancer in the first stage is surgery in the amount of com - plete debulking. Performing combined and advanced operations for advanced ovarian cancer affects the success of complete debulking and is reasonable.
{"title":"Long-term outcomes of surgical treatment of common ovarian cancer at the stage of primary debulking","authors":"M. N. Sekerskaya, S. Nikogosyan, V. Kuznetsov, A. S. Shevchuk, R. Tamrazov, V. Aliev","doi":"10.17650/2686-9594-2019-9-3-46-53","DOIUrl":"https://doi.org/10.17650/2686-9594-2019-9-3-46-53","url":null,"abstract":"Background . Comparative assessment of the long-term oncological results of extended, combined and standard surgical interventions. Materials and methods . The study included women with histologically verified ovarian cancer T3—4N0—1M0—1. Group A (experimental) patients underwent advanced and combined surgical interventions; group B (control) patients underwent standard surgical interventions. In the postoperative period, all patients received 6 courses of polychemotherapy with a combination of platinum and taxanes. The authors compared the frequency of achieving optimal and conditionally radical operations after performing extended and combined operations and standard surgical interventions, the structure, frequency and causes of intra- and postoperative complications, and overall and disease-free survival. Results . From 2010 to 2018, we selected 150 archived case histories of patients with advanced ovarian cancer (III-IV stages). 135 (90 %) patients were able to track the long-term results of treatment. In group A (experimental), complete debulking was achieved in 52.8 %, in group B (control) — 26.7 %. In group A, 6 (19.9 %) patients had postoperative complications of I-II degree of severity, 1 patient had postoperative complications of IIIA degree of severity, complications of IIIB-IV degree of severity in the study group did not occur (p = 0.05). In group B, intraoperative complications were observed in 27 (22.5 %) patients. Postoperative I—II degrees of severity were observed in 28 (23.3 %) patients, III—IV degrees of severity — in 8 (6.6 %). In group B, the overall survival rate was 54.7 months, and re¬lapse-free was 14.3 months, in group A — 79.2 months and 19 months respectively (p = 0.004 and <0.05). Conclusions . The method of choosing treatment for patients with advanced ovarian cancer in the first stage is surgery in the amount of com - plete debulking. Performing combined and advanced operations for advanced ovarian cancer affects the success of complete debulking and is reasonable.","PeriodicalId":34449,"journal":{"name":"Tazovaia khirurgiia i onkologiia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48980393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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