Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-3-50-53
E. Budoragin, Vladimir N. Gorshenеv, Mariya S. Petcherskaya, M. V. Bambura, Maksim A. Dragun, V. Akopyan
A biocompatible calcium-phosphate-collagen composite porous material, suitable for creating implants of given sizes and shapes, is synthesized accelerationally in the field of a hydroacoustic emitter, separated and conditioned in an ultrasonic self-cleaning filter. Afterwards, homogenization is performed and the obtained homogenate is used to form a body with the required size and shape, it is then exposed to lyophilic drying to form an implant, which samples sewn under the skin into the scruff of white mice for the control without causing undesirable changes in the adjacent tissues.
{"title":"Biocompatible calcium-phosphate-collagen composite","authors":"E. Budoragin, Vladimir N. Gorshenеv, Mariya S. Petcherskaya, M. V. Bambura, Maksim A. Dragun, V. Akopyan","doi":"10.53652/2782-1730-2022-3-3-50-53","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-3-50-53","url":null,"abstract":"A biocompatible calcium-phosphate-collagen composite porous material, suitable for creating implants of given sizes and shapes, is synthesized accelerationally in the field of a hydroacoustic emitter, separated and conditioned in an ultrasonic self-cleaning filter. Afterwards, homogenization is performed and the obtained homogenate is used to form a body with the required size and shape, it is then exposed to lyophilic drying to form an implant, which samples sewn under the skin into the scruff of white mice for the control without causing undesirable changes in the adjacent tissues.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":" 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133121370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-2-25-34
E. Petukhov, M. Chernykh, D. G. Ishchanov
In order to reduce the incidence of acute radiation toxicity during chemoradiation therapy in patients with rectal cancer, we proposed a prone position for patient on the treatment table using a BellyBoard fixation device. The data on 156 patients with rectal cancer who underwent radiation therapy were analyzed, 108 patients were treated in prone position, 48 patients were treated in supine position. We obtained data on the reduction of small intestine volumes treated with the calculated dose of 35, 40 and 45 Gy (V35, V40 and V45) when positioning in the prone position compared to positioning in the supine position when contouring the volume of the small intestine in a single block (bowelbag). Treatment in the prone position using a BellyBoard fixation device significantly reduced acute urogenital toxicity (by 30%) and significantly reduced the incidence of grade 2 cystitis by 4 times (from 12% to 3%) compared with treatment of the patient in supine position. Treatment in the prone position using a BellyBoard significantly reduced the incidence of grade 3 enterocolitis by 5 times (from 10% to 2%) compared with treatment of the patient in supine position. Despite a number of objective advantages of using a BellyBoard fixation device, treatment in prone position is associated with a decrease in the reproducibility of patient positioning compared to supine position. The main source of error when using a BellyBoard is the unstable position of its aperture relative to the patient's anatomy. Treatment in prone position, planning using intensity-modulated radiation therapy (IMRT) and volume-modulated arc radiation therapy (VMAT), determining the indents during the conversion from the clinical target volume (CTV) to the planned target volume (PTV) based on the analysis of interfractional displacements, determining the optimal multiplicity of visual control may help to reduce the acute toxicity of chemoradiotherapy in patients with local advanced rectal cancer.
{"title":"A set of techniques to reduce the toxicity of radiation therapy for locally advanced rectal cancer","authors":"E. Petukhov, M. Chernykh, D. G. Ishchanov","doi":"10.53652/2782-1730-2023-4-2-25-34","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-2-25-34","url":null,"abstract":"In order to reduce the incidence of acute radiation toxicity during chemoradiation therapy in patients with rectal cancer, we proposed a prone position for patient on the treatment table using a BellyBoard fixation device. The data on 156 patients with rectal cancer who underwent radiation therapy were analyzed, 108 patients were treated in prone position, 48 patients were treated in supine position. We obtained data on the reduction of small intestine volumes treated with the calculated dose of 35, 40 and 45 Gy (V35, V40 and V45) when positioning in the prone position compared to positioning in the supine position when contouring the volume of the small intestine in a single block (bowelbag). Treatment in the prone position using a BellyBoard fixation device significantly reduced acute urogenital toxicity (by 30%) and significantly reduced the incidence of grade 2 cystitis by 4 times (from 12% to 3%) compared with treatment of the patient in supine position. Treatment in the prone position using a BellyBoard significantly reduced the incidence of grade 3 enterocolitis by 5 times (from 10% to 2%) compared with treatment of the patient in supine position. Despite a number of objective advantages of using a BellyBoard fixation device, treatment in prone position is associated with a decrease in the reproducibility of patient positioning compared to supine position. The main source of error when using a BellyBoard is the unstable position of its aperture relative to the patient's anatomy. Treatment in prone position, planning using intensity-modulated radiation therapy (IMRT) and volume-modulated arc radiation therapy (VMAT), determining the indents during the conversion from the clinical target volume (CTV) to the planned target volume (PTV) based on the analysis of interfractional displacements, determining the optimal multiplicity of visual control may help to reduce the acute toxicity of chemoradiotherapy in patients with local advanced rectal cancer.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"95 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114050495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-2-43-46
L. Levonyan, Devletkhan S. Temirkhanov
Gastric cancer is a common form among malignant neoplasms in Russia, predominantly in the age group over 60 years old. Concomitant diseases influence the choice of treatment, the frequency and spectrum of treatment complications, and survival rates in this patient population.
{"title":"A case of treatment of gastric cancer in a patient with severe comorbidities","authors":"L. Levonyan, Devletkhan S. Temirkhanov","doi":"10.53652/2782-1730-2023-4-2-43-46","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-2-43-46","url":null,"abstract":"Gastric cancer is a common form among malignant neoplasms in Russia, predominantly in the age group over 60 years old. Concomitant diseases influence the choice of treatment, the frequency and spectrum of treatment complications, and survival rates in this patient population.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122376117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-2-61-68
Sergej A. Ignatiev, V. A. Pavlov, Sergej P. Kazakov
The medical and social urgency of the problem of age-related macular degeneration (AMD) and other degenerative diseases of the posterior pole of the eye is explained, first of all, by the fact that until now the disease is incurable and is characterized by a progressive course. AMD is one of the most common causes of vision loss. The incidence of AMD in Russia is 15 cases per 1,000 people. In the structure of primary AMD disability, patients of working age account for 21%, and due to the fact that there is a clear trend toward an increasing share of the elderly population, there is an annual increase in the incidence of AMD. In the last decade, pathological processes of the retina have become a global problem among people of different age categories, and this group of diseases includes a large number of different retinal dystrophies. In the last few years, there has been a clear trend towards the rejuvenation of such diseases. These changes are the most common causes of vision loss, especially the exudative form of age-related macular degeneration (AMD). Recent studies have shown that this form of AMD is associated not only with aging, vascular wall weakness and free-radical oxidation, but also with nonspecific immunostimulation and the potential role of cytomegalovirus infection, other viruses and microorganisms as a trigger agent. Not surprisingly, chronic infection of endothelial cells leads to the attraction of macrophages to the area of inflammation, their adhesion and synthesis of anti-inflammatory cytokines, which eventually stimulates the formation or activation of chorioidal neovascularization (CNV).
{"title":"Some dystrophic diseases of the posterior pole of the eye associated with chronic inflammation and viral transmission (review)","authors":"Sergej A. Ignatiev, V. A. Pavlov, Sergej P. Kazakov","doi":"10.53652/2782-1730-2023-4-2-61-68","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-2-61-68","url":null,"abstract":"The medical and social urgency of the problem of age-related macular degeneration (AMD) and other degenerative diseases of the posterior pole of the eye is explained, first of all, by the fact that until now the disease is incurable and is characterized by a progressive course. AMD is one of the most common causes of vision loss. The incidence of AMD in Russia is 15 cases per 1,000 people. In the structure of primary AMD disability, patients of working age account for 21%, and due to the fact that there is a clear trend toward an increasing share of the elderly population, there is an annual increase in the incidence of AMD. In the last decade, pathological processes of the retina have become a global problem among people of different age categories, and this group of diseases includes a large number of different retinal dystrophies. In the last few years, there has been a clear trend towards the rejuvenation of such diseases. These changes are the most common causes of vision loss, especially the exudative form of age-related macular degeneration (AMD). Recent studies have shown that this form of AMD is associated not only with aging, vascular wall weakness and free-radical oxidation, but also with nonspecific immunostimulation and the potential role of cytomegalovirus infection, other viruses and microorganisms as a trigger agent. Not surprisingly, chronic infection of endothelial cells leads to the attraction of macrophages to the area of inflammation, their adhesion and synthesis of anti-inflammatory cytokines, which eventually stimulates the formation or activation of chorioidal neovascularization (CNV).","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116309765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-2-5-11
A. Fursov, Nikolaj P. Potekhin, N. B. Lyapkova, Konstanin Yu. Gorodnichev
This article provides information on the prevalence of fibromuscular dysplasia and its role in the development of arterial hypertension, as well as gives the classification, summarizes approaches to diagnosis and treatment, describes cases of different localization of fibromuscular dysplasia and individual (personalized) management tactics for this category of patients.
{"title":"Fibromuscular dysplasia: a review of the literature and case reports","authors":"A. Fursov, Nikolaj P. Potekhin, N. B. Lyapkova, Konstanin Yu. Gorodnichev","doi":"10.53652/2782-1730-2022-3-2-5-11","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-2-5-11","url":null,"abstract":"This article provides information on the prevalence of fibromuscular dysplasia and its role in the development of arterial hypertension, as well as gives the classification, summarizes approaches to diagnosis and treatment, describes cases of different localization of fibromuscular dysplasia and individual (personalized) management tactics for this category of patients.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114179246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-2-12-17
V. Kovalenko, O. V. Barinov, E. E. Fufaev, I. V. Dmitrochenko, I. V. Kurakevich
Objective. To compare and evaluate the effectiveness of using methylene blue solutions to visualize lymph drainage pathways in laboratory animals (outbred rat). Materials and methods. In the experiment, 16 female outbred rats aged about 40 days, with an initial body weight of 180-220 g, kept in standard vivarium conditions, were used. Zolazepam (Zoletil®100) was used for anesthesia. Animals were randomized into 2 groups ― 8 in each. The first group was injected subcutaneously in the left thigh with a 1% aqueous solution of methylene blue, the second group ― solution of methylene blue with human serum albumin. Depending on the time of exposure, animals were divided randomly into 4 subgroups ― 15, 30, 45 and 60 minutes. There was evaluated the effectiveness of marking the lymph drainage pathways from the injection site. Results. The study demonstrated that the use of a 1% aqueous solution of methylene blue solution allows visualizing of the lymph drainage pathways when the preparation is exposed for 30 minutes. Staining of the lymph nodes of the next order occurs with an increase in exposure time. A solution of methylene blue in combination with human serum albumin stains the first node in the lymph drainage path 30 minutes after administration. The preparation is characterized by slow migration from the first-order lymph nodes (>60 minutes). Conclusion. The use of methylene blue solution in combination with serum albumin is characterized by slow migration from the first-order lymph nodes, which makes its use preferable for surgical interventions.
{"title":"Сomparison of efficiency of methylene blue preparations for visualization of lymph drainage pathways in the experiment","authors":"V. Kovalenko, O. V. Barinov, E. E. Fufaev, I. V. Dmitrochenko, I. V. Kurakevich","doi":"10.53652/2782-1730-2022-3-2-12-17","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-2-12-17","url":null,"abstract":"Objective. To compare and evaluate the effectiveness of using methylene blue solutions to visualize lymph drainage pathways in laboratory animals (outbred rat). Materials and methods. In the experiment, 16 female outbred rats aged about 40 days, with an initial body weight of 180-220 g, kept in standard vivarium conditions, were used. Zolazepam (Zoletil®100) was used for anesthesia. Animals were randomized into 2 groups ― 8 in each. The first group was injected subcutaneously in the left thigh with a 1% aqueous solution of methylene blue, the second group ― solution of methylene blue with human serum albumin. Depending on the time of exposure, animals were divided randomly into 4 subgroups ― 15, 30, 45 and 60 minutes. There was evaluated the effectiveness of marking the lymph drainage pathways from the injection site. Results. The study demonstrated that the use of a 1% aqueous solution of methylene blue solution allows visualizing of the lymph drainage pathways when the preparation is exposed for 30 minutes. Staining of the lymph nodes of the next order occurs with an increase in exposure time. A solution of methylene blue in combination with human serum albumin stains the first node in the lymph drainage path 30 minutes after administration. The preparation is characterized by slow migration from the first-order lymph nodes (>60 minutes). Conclusion. The use of methylene blue solution in combination with serum albumin is characterized by slow migration from the first-order lymph nodes, which makes its use preferable for surgical interventions.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126895105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-2-7-18
Dmitrij V. Trishkin, E. Kryukov, D. Davydov, V. Khominets, L. Brizhan', A. A. Kerimov
The features of morphological changes in gunshot fractures of the musculoskeletal system determine a continuous search for opportunities to improve the techniques of surgical wound treatment and immobilization devices for injured limbs. At the same time, the quality of fracture fixation largely defines both the result of immediate surgical treatment and the final long-term result of the wounded person's treatment. The article provides an analysis of the scientific literature and our own experience in the development, testing, implementation and use of external fixation devices for surgical and specialized trauma care at the stages of medical evacuation. The main achievements of the world and Russian science are presented. The main directions of search for ways to improve external fixation devices based on the achievements of modern science and innovative technologies are determined.
{"title":"Advancement of external fixation as a foundation for innovative staged treatment of the wounded in the extremities","authors":"Dmitrij V. Trishkin, E. Kryukov, D. Davydov, V. Khominets, L. Brizhan', A. A. Kerimov","doi":"10.53652/2782-1730-2023-4-2-7-18","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-2-7-18","url":null,"abstract":"The features of morphological changes in gunshot fractures of the musculoskeletal system determine a continuous search for opportunities to improve the techniques of surgical wound treatment and immobilization devices for injured limbs. At the same time, the quality of fracture fixation largely defines both the result of immediate surgical treatment and the final long-term result of the wounded person's treatment. The article provides an analysis of the scientific literature and our own experience in the development, testing, implementation and use of external fixation devices for surgical and specialized trauma care at the stages of medical evacuation. The main achievements of the world and Russian science are presented. The main directions of search for ways to improve external fixation devices based on the achievements of modern science and innovative technologies are determined.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125884997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-1-39-47
Andrey M. Shitov, Il'ja A. Sazonov, O. Belousova, S. Eliava
The article is devoted to the clinical manifestations and diagnosis of peripheral cerebral aneurysms. The clinical course of this disease was analyzed in 139 patients depending on topographic and anatomical features (106 patients with hemorrhagic stroke, 33 without a history of aneurysm rupture). The study included patients with peripheral aneurysms of the anterior cerebral, middle cerebral arteries, posterior cerebral, posterior inferior cerebellar arteries. A high incidence of seizures was noted in case of rupture of distal aneurysms (up to 10%). Quite typical for hemorrhage from peripheral aneurysms was the formation of an intracerebral hematoma (43.1%). A comparison of diagnostic methods for detection of this vascular pathology was performed: cerebral angiography (informative in 93.3%), СТ angiography (CTA) (90.9%) and magnetic resonance imaging in the vascular mode (12.2%). CTA is a highly effective method for diagnosing peripheral cerebral aneurysms and in most cases does not require additional invasive angiographic examination.
{"title":"Peripheral cerebral aneurysms: clinical picture and diagnostics","authors":"Andrey M. Shitov, Il'ja A. Sazonov, O. Belousova, S. Eliava","doi":"10.53652/2782-1730-2023-4-1-39-47","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-1-39-47","url":null,"abstract":"The article is devoted to the clinical manifestations and diagnosis of peripheral cerebral aneurysms. The clinical course of this disease was analyzed in 139 patients depending on topographic and anatomical features (106 patients with hemorrhagic stroke, 33 without a history of aneurysm rupture). The study included patients with peripheral aneurysms of the anterior cerebral, middle cerebral arteries, posterior cerebral, posterior inferior cerebellar arteries. A high incidence of seizures was noted in case of rupture of distal aneurysms (up to 10%). Quite typical for hemorrhage from peripheral aneurysms was the formation of an intracerebral hematoma (43.1%). A comparison of diagnostic methods for detection of this vascular pathology was performed: cerebral angiography (informative in 93.3%), СТ angiography (CTA) (90.9%) and magnetic resonance imaging in the vascular mode (12.2%). CTA is a highly effective method for diagnosing peripheral cerebral aneurysms and in most cases does not require additional invasive angiographic examination.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"164 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123137098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2021-2-4(6)-19-22
E. Budoragin, V. Gorshenev, V. Akopyan, M. V. Bambura, I. E. Budoragin
Development of new materials suitable for the formation of implants via 3D-printing, as well as stimulating biological tissues regeneration, is an urgent problem in traumatology, neurosurgery, andrology and urology. The article discusses the possibilities of improving the quality of 3D-printed implants by using paste-like thermoplastic compositions, as well as using ultrasound and a rotating magnetic field to prevent changes in viscosity in extruders for 3D-printers.
{"title":"Characteristics of medical implants 3D-printing","authors":"E. Budoragin, V. Gorshenev, V. Akopyan, M. V. Bambura, I. E. Budoragin","doi":"10.53652/2782-1730-2021-2-4(6)-19-22","DOIUrl":"https://doi.org/10.53652/2782-1730-2021-2-4(6)-19-22","url":null,"abstract":"Development of new materials suitable for the formation of implants via 3D-printing, as well as stimulating biological tissues regeneration, is an urgent problem in traumatology, neurosurgery, andrology and urology. The article discusses the possibilities of improving the quality of 3D-printed implants by using paste-like thermoplastic compositions, as well as using ultrasound and a rotating magnetic field to prevent changes in viscosity in extruders for 3D-printers.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128387532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-3-5-10
Sergej V. Chernavsky, A.V. Dorokhina, O. Artyushkevich, A. A. Stremoukhov, L.A. Kudentsova
Coronary heart disease (CHD) is an acute problem of modern medicine. Primarily, it is determined by the high prevalence of the disease among the working-age population, as well as by the considerable mortality and disability associated with it. Amiodarone (Am) is the drug of choice in the treatment of cardiac arrhythmias (CA), one of the frequent and threatening manifestations of CHD. Long-term use of the drug can lead to the development of primary hypothyroidism (HT), which significantly aggravates the course of cardiovascular diseases. Objective. To assess the cardiovascular system (CVS) of CHD patients with the development of amiodarone-associated hypothyroidism (AmHT). Material and methods. Analysis of case histories of 810 patients with CHD and various CA who were taking Am for sinus rhythm control was performed. The case histories were examined and a retrospective analysis was performed on the clinical course of CHD in 28 patients with AmHT before and after the development of thyreopathy. To evaluate the state of cardiovascular system the patients' complaints, objective examination data, electrocardiography (ECG) and echocardiography (EchoCG) were assessed. Results. Long-term intake of Am by patients with CHD results in primary HT in 3.4% of cases. The formation of thyreopathy significantly affects the course of the disease. Patients show a 19.6% increase in myocardial volume indices and a 22.7% decrease in myocardial contractility, with a 30.2% increase in left ventricular myocardial mass (LVMM). Conclusion. Amiodarone-associated hypothyroidism is one of the significant complications developing in patients taking the drug for a long period of time. The formation of thyreopathy in patients with CHD significantly aggravates the course of the underlying disease, which should be taken into account when prescribing treatment and dynamic monitoring
{"title":"Features of clinical manifestations of coronary heart disease in patients with amiodarone-associated hypothyroidism","authors":"Sergej V. Chernavsky, A.V. Dorokhina, O. Artyushkevich, A. A. Stremoukhov, L.A. Kudentsova","doi":"10.53652/2782-1730-2022-3-3-5-10","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-3-5-10","url":null,"abstract":"Coronary heart disease (CHD) is an acute problem of modern medicine. Primarily, it is determined by the high prevalence of the disease among the working-age population, as well as by the considerable mortality and disability associated with it. Amiodarone (Am) is the drug of choice in the treatment of cardiac arrhythmias (CA), one of the frequent and threatening manifestations of CHD. Long-term use of the drug can lead to the development of primary hypothyroidism (HT), which significantly aggravates the course of cardiovascular diseases. Objective. To assess the cardiovascular system (CVS) of CHD patients with the development of amiodarone-associated hypothyroidism (AmHT). Material and methods. Analysis of case histories of 810 patients with CHD and various CA who were taking Am for sinus rhythm control was performed. The case histories were examined and a retrospective analysis was performed on the clinical course of CHD in 28 patients with AmHT before and after the development of thyreopathy. To evaluate the state of cardiovascular system the patients' complaints, objective examination data, electrocardiography (ECG) and echocardiography (EchoCG) were assessed. Results. Long-term intake of Am by patients with CHD results in primary HT in 3.4% of cases. The formation of thyreopathy significantly affects the course of the disease. Patients show a 19.6% increase in myocardial volume indices and a 22.7% decrease in myocardial contractility, with a 30.2% increase in left ventricular myocardial mass (LVMM). Conclusion. Amiodarone-associated hypothyroidism is one of the significant complications developing in patients taking the drug for a long period of time. The formation of thyreopathy in patients with CHD significantly aggravates the course of the underlying disease, which should be taken into account when prescribing treatment and dynamic monitoring","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132611576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：