Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-3-20-29
A. Datsko, F. A. Orlov, O. N. Petrova, Stanislav I. Dorohin
In the practice of a military doctor, it is often necessary to make a differential diagnosis between neurocirculatory asthenia (NCA) of the hypertensive type and hypertensive disease (HD) stage I among young and middle-aged military personnel. Both hypertensive NCA and stage I HD patients under examination had autonomic disturbances of varying severity. In patients with NCA of the hypertensive type, the frequency and severity of the autonomic disturbances was higher. It is often not possible to make an accurate differential diagnosis of two diseases based on data from a standard clinical examination and basic laboratory and instrumental investigation methods. By constructing prediction equations for a particular patient with a probability of more than 96.1%, it is possible to calculate the acceptability of relating him to a certain diagnosis.
{"title":"Аpplication of regression analysis for differential diagnosis of essential arterial hypertension and neurocirculatory asthenia of the hypertensive type","authors":"A. Datsko, F. A. Orlov, O. N. Petrova, Stanislav I. Dorohin","doi":"10.53652/2782-1730-2022-3-3-20-29","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-3-20-29","url":null,"abstract":"In the practice of a military doctor, it is often necessary to make a differential diagnosis between neurocirculatory asthenia (NCA) of the hypertensive type and hypertensive disease (HD) stage I among young and middle-aged military personnel. Both hypertensive NCA and stage I HD patients under examination had autonomic disturbances of varying severity. In patients with NCA of the hypertensive type, the frequency and severity of the autonomic disturbances was higher. It is often not possible to make an accurate differential diagnosis of two diseases based on data from a standard clinical examination and basic laboratory and instrumental investigation methods. By constructing prediction equations for a particular patient with a probability of more than 96.1%, it is possible to calculate the acceptability of relating him to a certain diagnosis.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"628 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116080403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-4-24-31
Aleksej N. Kulikov, Sergej V. Churashov, Kirill Yu. Gaiduk, V. A. Pavlov, M. V. Sukhinin, V. E. Kurnosov
The main feature of modern armed conflicts is the use of new weapons and, as a result, changes in the nature and structure of eye injuries. This feature, on the one hand, and the rapid progress of medical science, on the other hand, require a rapid response to the changing operational situation using the resources of modern ophthalmology in order to provide care to wounded and injured ophthalmic patients efficiently and rationally. There are some differences in approaches to pre-hospital self- and mutual aid to the wounded with ophtalmic injuries on the battlefield in different schools of military medical training and tactical medicine. Some use a binocular bandage, while others use a rigid eye shield. The complexity and variety of visual injuries require good practical skills and experience in order to perform high-quality surgical treatment of perforated corneal and scleral wounds in open eye trauma. This necessitates a thorough training of specialists with practical skills. The issue of medical supply of units providing specialized care at the stages of medical evacuation, which includes a military ophthalmologist, is particularly significant. The problem of reasonable and rational update of the ophthalmological equipment at the stages of medical evacuation requires active discussion. There is still the question of the use of effective protective equipment for the eye during combat operations, which, without limiting visual function, could prevent combat eye injuries, most often caused by small fragments and secondary wounding projectiles.
{"title":"Organization of eye care in modern armed conflicts: state and prospects","authors":"Aleksej N. Kulikov, Sergej V. Churashov, Kirill Yu. Gaiduk, V. A. Pavlov, M. V. Sukhinin, V. E. Kurnosov","doi":"10.53652/2782-1730-2022-3-4-24-31","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-4-24-31","url":null,"abstract":"The main feature of modern armed conflicts is the use of new weapons and, as a result, changes in the nature and structure of eye injuries. This feature, on the one hand, and the rapid progress of medical science, on the other hand, require a rapid response to the changing operational situation using the resources of modern ophthalmology in order to provide care to wounded and injured ophthalmic patients efficiently and rationally. There are some differences in approaches to pre-hospital self- and mutual aid to the wounded with ophtalmic injuries on the battlefield in different schools of military medical training and tactical medicine. Some use a binocular bandage, while others use a rigid eye shield. The complexity and variety of visual injuries require good practical skills and experience in order to perform high-quality surgical treatment of perforated corneal and scleral wounds in open eye trauma. This necessitates a thorough training of specialists with practical skills. The issue of medical supply of units providing specialized care at the stages of medical evacuation, which includes a military ophthalmologist, is particularly significant. The problem of reasonable and rational update of the ophthalmological equipment at the stages of medical evacuation requires active discussion. There is still the question of the use of effective protective equipment for the eye during combat operations, which, without limiting visual function, could prevent combat eye injuries, most often caused by small fragments and secondary wounding projectiles.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125259892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2021-2-4(6)-51-55
A. Vasiukevich, A.M., Fedosyuk, S. Puchkov, A. Fokin
A 77-year-old patient was operated on for local recurrence of pleomorphic sarcoma of the left half of the chest wall with the involvement of three ribs in the tumor process. Successful extensive resection of the chest wall with Codubix plastic material made it possible to preserve the skeleton. Periodic accumulation of uninfected exudate can be considered as reactive plervritis, which required periodic evacuation of the contents of the left pleural cavity.
{"title":"Resection of the chest wall with Codubix alloplasty polymer material for treating recurrent sarcoma","authors":"A. Vasiukevich, A.M., Fedosyuk, S. Puchkov, A. Fokin","doi":"10.53652/2782-1730-2021-2-4(6)-51-55","DOIUrl":"https://doi.org/10.53652/2782-1730-2021-2-4(6)-51-55","url":null,"abstract":"A 77-year-old patient was operated on for local recurrence of pleomorphic sarcoma of the left half of the chest wall with the involvement of three ribs in the tumor process. Successful extensive resection of the chest wall with Codubix plastic material made it possible to preserve the skeleton. Periodic accumulation of uninfected exudate can be considered as reactive plervritis, which required periodic evacuation of the contents of the left pleural cavity.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133380956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-3-45-49
Valerij V. Bagrov, A. Dikov, V. Krylov
An overview of a monitoring system that provides rapid, high-quality imaging with minimal preparation and allows real-time monitoring of molecular, cellular and genetic diagnostics is presented.
概述了一个监测系统，提供快速，高质量的成像与最少的准备，并允许实时监测分子，细胞和遗传诊断。
{"title":"Visualization and analysis of cells with automatic counting in real time using a high-tech microscope","authors":"Valerij V. Bagrov, A. Dikov, V. Krylov","doi":"10.53652/2782-1730-2022-3-3-45-49","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-3-45-49","url":null,"abstract":"An overview of a monitoring system that provides rapid, high-quality imaging with minimal preparation and allows real-time monitoring of molecular, cellular and genetic diagnostics is presented.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130376125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-32-38
E. Egorova, Zavazhat M. Magomedova
The aim of the study was to assess the capabilities of magnetic resonance imaging (MRI) in the diagnosis of complications in patients with combined kidney and ureteral injuries during different periods of traumatic disease. The observation group included 139 patients aged from 18 to 72 years with renal and ureteral injuries, who were injured in traffic accidents. Complications of renal trauma occurred in 74 of 128 patients with isolated and combined injuries (59.2%), strictures were observed in 9 of 11 patients with ureteral trauma in the late period, and 1 of them had a failure of vesicoureteral anastomosis. The most common complication in the early and late periods of traumatic disease, occurring in 25.0% of cases, was pyelonephritis; patients with abscesses (12.5%) and acute renal failure (11.7%) were also common. The methods of choice for the diagnosis of combined injuries in the acute period were: ultrasound examinations according to the eFAST protocol and multislice computed tomography according to the “Polytrauma” protocol. Multiparametric magnetic resonance imaging (mpMRI) of the kidneys and ureters was indicated in the periods of early and late manifestations of traumatic disease to detect renal complications when there is a discrepancy between clinical data, ultrasound and multislice computed tomography (MSCT) findings, and there are contraindications for MSCT with intravenous contrast.
{"title":"Features of examination of patients with kidney and ureter injuries","authors":"E. Egorova, Zavazhat M. Magomedova","doi":"10.53652/2782-1730-2023-4-32-38","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-32-38","url":null,"abstract":"The aim of the study was to assess the capabilities of magnetic resonance imaging (MRI) in the diagnosis of complications in patients with combined kidney and ureteral injuries during different periods of traumatic disease. The observation group included 139 patients aged from 18 to 72 years with renal and ureteral injuries, who were injured in traffic accidents. Complications of renal trauma occurred in 74 of 128 patients with isolated and combined injuries (59.2%), strictures were observed in 9 of 11 patients with ureteral trauma in the late period, and 1 of them had a failure of vesicoureteral anastomosis. The most common complication in the early and late periods of traumatic disease, occurring in 25.0% of cases, was pyelonephritis; patients with abscesses (12.5%) and acute renal failure (11.7%) were also common. The methods of choice for the diagnosis of combined injuries in the acute period were: ultrasound examinations according to the eFAST protocol and multislice computed tomography according to the “Polytrauma” protocol. Multiparametric magnetic resonance imaging (mpMRI) of the kidneys and ureters was indicated in the periods of early and late manifestations of traumatic disease to detect renal complications when there is a discrepancy between clinical data, ultrasound and multislice computed tomography (MSCT) findings, and there are contraindications for MSCT with intravenous contrast.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130781892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2021-2-4(6)-56-61
E.S. Vasechko, М.Yu. Pavlov
Understanding asymptomatic bacteriuria can help clinicians in selecting rational antimicrobial therapy and improve disease outcomes.
了解无症状细菌性尿症可以帮助临床医生选择合理的抗菌药物治疗，改善疾病预后。
{"title":"Asymptomatic bacteriuria","authors":"E.S. Vasechko, М.Yu. Pavlov","doi":"10.53652/2782-1730-2021-2-4(6)-56-61","DOIUrl":"https://doi.org/10.53652/2782-1730-2021-2-4(6)-56-61","url":null,"abstract":"Understanding asymptomatic bacteriuria can help clinicians in selecting rational antimicrobial therapy and improve disease outcomes.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127299485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2022-3-4-79-84
Ol'ga A. Breslavtseva, Galina V. Shekurina
Currently, the implementation of the import substitution strategy is one of the priorities for the Government of the Russian Federation. The objective of this work is to examine the declared planned indicators of import substitution and their actual achievement, to assess the possibility of meeting the set indicators in 2022, as well as to highlight the information resources and data to be used in the procurement of certain types of medical devices.
{"title":"Current issues of import substitution in the procurement of medical institutions","authors":"Ol'ga A. Breslavtseva, Galina V. Shekurina","doi":"10.53652/2782-1730-2022-3-4-79-84","DOIUrl":"https://doi.org/10.53652/2782-1730-2022-3-4-79-84","url":null,"abstract":"Currently, the implementation of the import substitution strategy is one of the priorities for the Government of the Russian Federation. The objective of this work is to examine the declared planned indicators of import substitution and their actual achievement, to assess the possibility of meeting the set indicators in 2022, as well as to highlight the information resources and data to be used in the procurement of certain types of medical devices.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"5 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115870090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2021-2-4(6)-45-50
D. Grechukhin, A. Kerimov, D. Naida
Osteoarthritis (OA) is the most common disease in orthopedic practice, which is characterized by chronic pain in the joints and joint dysfunction. OA of the carpometacarpal joint (CMCJ) of the thumb is the most common type of hand osteoarthritis. The aim of the work was to evaluate the effect of ultrasound-guided intraarticular injection of hyaluronic acid (HA) for osteoarthritis of the CMCJ of the thumb (stage II–III Kellgren–Lawrence) in patients with persistent pain syndrome for 3 months and with failure of NSAIDs therapy. The study included 18 patients with stage II–III CMCJ OA who received intraarticular injection of HA drugs with a mass of 2400,000 kDa in the volume of 1.0 ml twice with an interval of 10 days. Demographic characteristics, body mass index, stage of osteoarthritis (CMCJ), severity of pain syndrome according to visual analog scale (VAS) and upper limb function assessed with the DASH questionnaire (disabilities of the arm, shoulder, and hand) were evaluated. Data was collected at the start of the study and in 1, 3 and 6 months after the first injection. DASH and VAS scores were compared using a variance analysis of repeated measurements. The non-parametric Friedman criteria was used to check the differences in proportions. The value of p<0.05 was considered statistically significant. There was a significant improvement in DASH values in 1, 3 and 6 months after injection. There were statistically significant differences between DASH values at the start of treatment and 6 months after therapy: χ²=45.7; df 3, p<0.001. There was also a significant decrease in the average VAS score during the study in 1, 3 and 6 months after the first injection. The differences in VAS score at the start of treatment and in 6 months reached statistical significance: χ²=47.1; df 3, p<0.001. Improvement occurred after 1 month after first injection and persisted throughout the entire follow-up period for 6 months. HA injections provide pain relief and improve upper limb function in patients who are resistant to analgesics and physiotherapy. A significant decrease in pain was observed as early as 1 month after the first intra-articular injection of GNC. The obtained results already allow us to recommend the use of HA drugs for CMCJ OA.
{"title":"Ultrasound-guided intra-articular injection of hyaluronic acid for osteoarthritis of the carpometacarpal joint of the thumb","authors":"D. Grechukhin, A. Kerimov, D. Naida","doi":"10.53652/2782-1730-2021-2-4(6)-45-50","DOIUrl":"https://doi.org/10.53652/2782-1730-2021-2-4(6)-45-50","url":null,"abstract":"Osteoarthritis (OA) is the most common disease in orthopedic practice, which is characterized by chronic pain in the joints and joint dysfunction. OA of the carpometacarpal joint (CMCJ) of the thumb is the most common type of hand osteoarthritis. The aim of the work was to evaluate the effect of ultrasound-guided intraarticular injection of hyaluronic acid (HA) for osteoarthritis of the CMCJ of the thumb (stage II–III Kellgren–Lawrence) in patients with persistent pain syndrome for 3 months and with failure of NSAIDs therapy. The study included 18 patients with stage II–III CMCJ OA who received intraarticular injection of HA drugs with a mass of 2400,000 kDa in the volume of 1.0 ml twice with an interval of 10 days. Demographic characteristics, body mass index, stage of osteoarthritis (CMCJ), severity of pain syndrome according to visual analog scale (VAS) and upper limb function assessed with the DASH questionnaire (disabilities of the arm, shoulder, and hand) were evaluated. Data was collected at the start of the study and in 1, 3 and 6 months after the first injection. DASH and VAS scores were compared using a variance analysis of repeated measurements. The non-parametric Friedman criteria was used to check the differences in proportions. The value of p<0.05 was considered statistically significant. There was a significant improvement in DASH values in 1, 3 and 6 months after injection. There were statistically significant differences between DASH values at the start of treatment and 6 months after therapy: χ²=45.7; df 3, p<0.001. There was also a significant decrease in the average VAS score during the study in 1, 3 and 6 months after the first injection. The differences in VAS score at the start of treatment and in 6 months reached statistical significance: χ²=47.1; df 3, p<0.001. Improvement occurred after 1 month after first injection and persisted throughout the entire follow-up period for 6 months. HA injections provide pain relief and improve upper limb function in patients who are resistant to analgesics and physiotherapy. A significant decrease in pain was observed as early as 1 month after the first intra-articular injection of GNC. The obtained results already allow us to recommend the use of HA drugs for CMCJ OA.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125267299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-2-69-76
D. O. Kolmakov, Andrej V. Korolev, Dmitrij O. Ilyin, D. Naida
This review highlights and summarizes the main features of the anatomy of the tendon of the long head of the biceps of the shoulder (LHBS Literature data on the structure, age and morphological peculiarities were collected, and predictors of inflammation of the LHBS tendon were identified. Anatomical features determine the tactics and efficacy of surgical treatment.
{"title":"Anatomical features of the tendon of the long head of the biceps of the shoulder","authors":"D. O. Kolmakov, Andrej V. Korolev, Dmitrij O. Ilyin, D. Naida","doi":"10.53652/2782-1730-2023-4-2-69-76","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-2-69-76","url":null,"abstract":"This review highlights and summarizes the main features of the anatomy of the tendon of the long head of the biceps of the shoulder (LHBS Literature data on the structure, age and morphological peculiarities were collected, and predictors of inflammation of the LHBS tendon were identified. Anatomical features determine the tactics and efficacy of surgical treatment.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126527066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.53652/2782-1730-2023-4-1-55-62
O. Rukavitsyn, Viktorija V. Tutaeva, E. Ignatieva
Extramedullary and paraskeletal plasmacytomas are not common and are usually one of the possible complications of multiple myeloma. This variant of the disease is more aggressive, less responsive to therapy, and recurs more often than conventional multiple myeloma. In our work, we described two cases of aggressively ongoing multiple myeloma with a mixed plasmacytic variant diagnosed at the time of setting the diagnosis. In both cases, a rapid progressive course was observed despite the wide range of both the newest drugs and the classical chemotherapy drugs used during treatment. Thus, this variant of the disease remains most often resistant to the therapy, with an unfavorable prognosis, and requires further study and improvement of the treatment approach to improve outcomes.
{"title":"Mixed type plasmacytoma with multiple myeloma: therapy and prognosis","authors":"O. Rukavitsyn, Viktorija V. Tutaeva, E. Ignatieva","doi":"10.53652/2782-1730-2023-4-1-55-62","DOIUrl":"https://doi.org/10.53652/2782-1730-2023-4-1-55-62","url":null,"abstract":"Extramedullary and paraskeletal plasmacytomas are not common and are usually one of the possible complications of multiple myeloma. This variant of the disease is more aggressive, less responsive to therapy, and recurs more often than conventional multiple myeloma. In our work, we described two cases of aggressively ongoing multiple myeloma with a mixed plasmacytic variant diagnosed at the time of setting the diagnosis. In both cases, a rapid progressive course was observed despite the wide range of both the newest drugs and the classical chemotherapy drugs used during treatment. Thus, this variant of the disease remains most often resistant to the therapy, with an unfavorable prognosis, and requires further study and improvement of the treatment approach to improve outcomes.","PeriodicalId":344630,"journal":{"name":"Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko","volume":"67 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132238260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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