Pub Date : 2025-01-01Epub Date: 2025-02-18DOI: 10.1007/s43939-025-00208-8
Seyedtaghi Mousavi, John G Hardy
In-situ microscopic methods can help researchers to analyse microstructural changes of materials structures under different conditions (e.g., temperature and pressure) at various length scales. Digital Image Correlation (DIC) combines image registration and tracking to enable accurate measurements of changes in materials in 2D and 3D. This review focuses on combining microscopy and DIC to study the properties of materials (including natural/synthetic biomaterials, biological samples and their composites) in academic, public and industry settings, including exciting examples of bioimaging.
{"title":"In-situ microscopy and digital image correlation to study the mechanical characteristics of polymer-based materials.","authors":"Seyedtaghi Mousavi, John G Hardy","doi":"10.1007/s43939-025-00208-8","DOIUrl":"10.1007/s43939-025-00208-8","url":null,"abstract":"<p><p>In-situ microscopic methods can help researchers to analyse microstructural changes of materials structures under different conditions (e.g., temperature and pressure) at various length scales. Digital Image Correlation (DIC) combines image registration and tracking to enable accurate measurements of changes in materials in 2D and 3D. This review focuses on combining microscopy and DIC to study the properties of materials (including natural/synthetic biomaterials, biological samples and their composites) in academic, public and industry settings, including exciting examples of bioimaging.</p>","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"5 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-03-22DOI: 10.1007/s43939-025-00240-8
Samuel Mugo, Scott Robertson, Weihao Lu
Polymer based microneedle transdermal drug delivery system fits the criterion for an efficient patient compliant drug delivery system of the future. Smart and controlled microneedle drug delivery systems remain an emerging research area. One of the objectives of this study was to design an accessible approach of molding microneedles using a beeswax mold. The second objective was to evaluate a polymer-based microneedle drug release transdermal platform fabricated via layer by layer (LbL) assembly of conductive polydimethylsiloxane integrated with carbon nanotubes, cellulose nanocrystal and polyaniline (PDMS@CNT/CNC@PANI). The electrically conductive PDMS@CNT/CNC@PANI microneedle patch provides a platform for drug loading, stabilization and transdermal controlled drug release. The drug loaded PDMS@CNT/CNC@PANI microneedle patch was evaluated for diffusion and voltage mediated transdermal delivery of thymol blue and rutin as model compounds. Chicken skin was used as an analogue of human skin. Both electrochemical and passive release from the rutin loaded PDMS@CNC/CNT microneedle patch resulted in ~ 66%. On the other hand, the PDMS@CNC/CNT@PANI patch loaded with rutin resulted in 66-84% release. The results show the novel microneedle patches could effectively release rutin in a controlled manner, and as such showed promise for potential use in clinical drug release applications.
Graphical abstract:
Supplementary information: The online version contains supplementary material available at 10.1007/s43939-025-00240-8.
{"title":"Transdermal microneedle patch for antioxidants release.","authors":"Samuel Mugo, Scott Robertson, Weihao Lu","doi":"10.1007/s43939-025-00240-8","DOIUrl":"10.1007/s43939-025-00240-8","url":null,"abstract":"<p><p>Polymer based microneedle transdermal drug delivery system fits the criterion for an efficient patient compliant drug delivery system of the future. Smart and controlled microneedle drug delivery systems remain an emerging research area. One of the objectives of this study was to design an accessible approach of molding microneedles using a beeswax mold. The second objective was to evaluate a polymer-based microneedle drug release transdermal platform fabricated via layer by layer (LbL) assembly of conductive polydimethylsiloxane integrated with carbon nanotubes, cellulose nanocrystal and polyaniline (PDMS@CNT/CNC@PANI). The electrically conductive PDMS@CNT/CNC@PANI microneedle patch provides a platform for drug loading, stabilization and transdermal controlled drug release. The drug loaded PDMS@CNT/CNC@PANI microneedle patch was evaluated for diffusion and voltage mediated transdermal delivery of thymol blue and rutin as model compounds. Chicken skin was used as an analogue of human skin. Both electrochemical and passive release from the rutin loaded PDMS@CNC/CNT microneedle patch resulted in ~ 66%. On the other hand, the PDMS@CNC/CNT@PANI patch loaded with rutin resulted in 66-84% release. The results show the novel microneedle patches could effectively release rutin in a controlled manner, and as such showed promise for potential use in clinical drug release applications.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43939-025-00240-8.</p>","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"5 1","pages":"64"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.1007/s43939-024-00096-4
N. A. Reddy, P. S. Chandana
{"title":"Microstructural analysis and densification of ordinary Portland cement mortars incorporated with minimal nano-TiO2: intermixing and surface coating on both fresh and hardened surfaces","authors":"N. A. Reddy, P. S. Chandana","doi":"10.1007/s43939-024-00096-4","DOIUrl":"https://doi.org/10.1007/s43939-024-00096-4","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"24 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.1007/s43939-024-00092-8
Daniela Rizzo, Anna Somigliana, Stefania Marmai, Debora Cusumano, Laura Clerici, Marco Volante
{"title":"Product classes characterization at micro-scale level applied to granular wastes fractions < 20 mm: a case-study","authors":"Daniela Rizzo, Anna Somigliana, Stefania Marmai, Debora Cusumano, Laura Clerici, Marco Volante","doi":"10.1007/s43939-024-00092-8","DOIUrl":"https://doi.org/10.1007/s43939-024-00092-8","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141826362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1007/s43939-024-00098-2
J. M. Córdoba Gallego
{"title":"Pressureless sintering kinetics analysis of Ti3SiC2 and Ti2AlC powdered MAX phases","authors":"J. M. Córdoba Gallego","doi":"10.1007/s43939-024-00098-2","DOIUrl":"https://doi.org/10.1007/s43939-024-00098-2","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"5 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.1007/s43939-024-00090-w
Gareth Collett, Jacqueline Akhavan, Richard Critchley
{"title":"Understanding the explosion risk presented by ammonium nitrate and aluminium home-made explosives detonated as surface charges in hexahedral main charge containers","authors":"Gareth Collett, Jacqueline Akhavan, Richard Critchley","doi":"10.1007/s43939-024-00090-w","DOIUrl":"https://doi.org/10.1007/s43939-024-00090-w","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"22 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-05DOI: 10.1007/s43939-024-00086-6
B. H. Patel, D. P. Panchal, S. Chaudhari
{"title":"Per-acetic acid effect on separation of banana fiber and their dyeing with natural dyes","authors":"B. H. Patel, D. P. Panchal, S. Chaudhari","doi":"10.1007/s43939-024-00086-6","DOIUrl":"https://doi.org/10.1007/s43939-024-00086-6","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":" 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1007/s43939-024-00097-3
Karabo G. Sekwele, S. Tichapondwa, W. Mhike
{"title":"Cellulose, graphene and graphene-cellulose composite aerogels and their application in water treatment: a review","authors":"Karabo G. Sekwele, S. Tichapondwa, W. Mhike","doi":"10.1007/s43939-024-00097-3","DOIUrl":"https://doi.org/10.1007/s43939-024-00097-3","url":null,"abstract":"","PeriodicalId":34625,"journal":{"name":"Discover Materials","volume":"286 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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