Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.139
Hyun Ju Kim, Sang‐Hyun Choi, B. Chun, Dong Hoon Kim
Received: 8 December, 2011, Accepted: 12 December, 2011 Address for correspondence: Dong-Hoon Kim, M.D., Ph.D. Department of Pharmacology, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul 136-705, Korea Tel: +82.2-920-6237, Fax: +82.2-927-0824 E-mail: LDHKIM@korea.ac.kr 질병의심각성을고려해볼때 이에대처할방법은절대적으 , 로 부족하다 4) 특히 체내에서 에너지균형 . , (energy balance) 을조절하는신경내분비계기전(neuroendocrine mechanism) 의강력한방어기전으로장기투여목적의치료제로사용할 수있는비만치료제는극히드물다 5, 6) 미국과유럽의경우 . 년에 과 년에 가 각각 장기 2010 sibutramine 2008 rimonabant 투여시유발되는남용과부작용으로인하여승인이취소되 었으며 현재승인된비만치료제는 인 , lipase inhibitor orlistat 이유일하다 4, . 에너지균형은 에너지섭취 와 에너지소비 (energy intake) 가두축을이루어상호작용함으로써엄 (energy expenditure) 격하게 유지되고있다 체중 의증가는에너지 . (body weight) 균형 조절기전이 손상되어 지속적인 에너지섭취의 증가 또 는에너지소비의감소가초래되어유발된다 5, 6) 렙틴저항성 . 은 손상된 에너지균형 조절기전의 주원인 (leptin resistance) 에너지균형에 미치는 흰지방조직 내 혈관의 역할
2011年12月12日，2011年12月12日Address for correspondence:Dong-Hoon Kim, m.d.， Ph.D. Department of Pharmacology, Korea University College of Medicine, 126- 1,5 -ga Anam- Dong, Seongbuk-gu, Seoul 136-705, Korea Tel: +82.2-920-6237, Fax: +82.2-927-0824 E-mail:LDHKIM@korea.ac.kr考虑到疾病疑似症状的觉醒，应对方法是绝对的，不足4)特别是在体内能量平衡。，调节(energy balance)的神经内分泌系统机制(neuroendocrine mechanism)的强力的韩医期前，能够作为长期治疗目的的肥胖治疗剂极少，5,6)美国和欧洲。年和年分别因服用2010 sibutramine 2008 rimonabant引起的滥用过度作用而取消了认可，目前认可的肥胖治疗药物只有磷、lipase inhibitor orlistat 4。能量平衡是由能量摄取和能量消耗(energy intake)组成双轴相互作用来维持的。体重的增加是能量。(body weight)平衡调节机制受损，导致持续能量摄取增加，又导致能源消费减少，从而导致发病5,6)胰岛素抵抗性。白脂肪组织内血管对能量平衡的作用(leptin resistance)
{"title":"The Role of Adipose Tissue Vasculature in Energy Balance","authors":"Hyun Ju Kim, Sang‐Hyun Choi, B. Chun, Dong Hoon Kim","doi":"10.6065/JKSPE.2011.16.3.139","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.139","url":null,"abstract":"Received: 8 December, 2011, Accepted: 12 December, 2011 Address for correspondence: Dong-Hoon Kim, M.D., Ph.D. Department of Pharmacology, Korea University College of Medicine, 126-1, 5-ga Anam-dong, Seongbuk-gu, Seoul 136-705, Korea Tel: +82.2-920-6237, Fax: +82.2-927-0824 E-mail: LDHKIM@korea.ac.kr 질병의심각성을고려해볼때 이에대처할방법은절대적으 , 로 부족하다 4) 특히 체내에서 에너지균형 . , (energy balance) 을조절하는신경내분비계기전(neuroendocrine mechanism) 의강력한방어기전으로장기투여목적의치료제로사용할 수있는비만치료제는극히드물다 5, 6) 미국과유럽의경우 . 년에 과 년에 가 각각 장기 2010 sibutramine 2008 rimonabant 투여시유발되는남용과부작용으로인하여승인이취소되 었으며 현재승인된비만치료제는 인 , lipase inhibitor orlistat 이유일하다 4, . 에너지균형은 에너지섭취 와 에너지소비 (energy intake) 가두축을이루어상호작용함으로써엄 (energy expenditure) 격하게 유지되고있다 체중 의증가는에너지 . (body weight) 균형 조절기전이 손상되어 지속적인 에너지섭취의 증가 또 는에너지소비의감소가초래되어유발된다 5, 6) 렙틴저항성 . 은 손상된 에너지균형 조절기전의 주원인 (leptin resistance) 에너지균형에 미치는 흰지방조직 내 혈관의 역할","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127388830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.172
Yong Hyuk Kim, M. Song, Sochung Chung
Purpose: The objective of this study was to determine the type differences of diabetes by analyzing the growth status and body composition of newly diagnosed diabetic adolescent girls. Methods: The study included 6 type 1 diabetic adolescent girls (age 11.7 ± 1.9 years) and 6 type 2 diabetic adole- scent girls (age 14.4 ± 2.6 years). The height, weight and body composition of fat mass and fat-free mass were measured in each patient. Body mass index (BMI), fat mass index (FMI), fat free mass index (FFMI) and percent body fat (PBF) were calculated and each component was plotted on a body composition chart. Results: Type 2 diabetic adolescent girls seemed to be taller and heavier compared to type 1 diabetic girls, but the differences in height and weight z-score were not significant. BMI, FFMI, FMI, PBF were also higher in type 2 diabetic girls. The body composition chart revealed that type 2 diabetic girls had significantly higher FMI and PBF. In type 1 diabetic girls, FFMI was lower compared to type 2 diabetic girls. The BMI difference between diabetes types was explained with the difference in FFMI as well as FMI. Conclusion: The components of body composition differ according to diabetes type in adolescent girls. Measuring the body composition of diabetic girls might help to promote growth and adequate FFM gain during childhood. In diabetes control, diet and exercise should be emphasized along with insulin treatment.
{"title":"Body Composition Analysis in Newly Diagnosed Diabetic Adolescent Girls","authors":"Yong Hyuk Kim, M. Song, Sochung Chung","doi":"10.6065/JKSPE.2011.16.3.172","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.172","url":null,"abstract":"Purpose: The objective of this study was to determine the type differences of diabetes by analyzing the growth status and body composition of newly diagnosed diabetic adolescent girls. Methods: The study included 6 type 1 diabetic adolescent girls (age 11.7 ± 1.9 years) and 6 type 2 diabetic adole- scent girls (age 14.4 ± 2.6 years). The height, weight and body composition of fat mass and fat-free mass were measured in each patient. Body mass index (BMI), fat mass index (FMI), fat free mass index (FFMI) and percent body fat (PBF) were calculated and each component was plotted on a body composition chart. Results: Type 2 diabetic adolescent girls seemed to be taller and heavier compared to type 1 diabetic girls, but the differences in height and weight z-score were not significant. BMI, FFMI, FMI, PBF were also higher in type 2 diabetic girls. The body composition chart revealed that type 2 diabetic girls had significantly higher FMI and PBF. In type 1 diabetic girls, FFMI was lower compared to type 2 diabetic girls. The BMI difference between diabetes types was explained with the difference in FFMI as well as FMI. Conclusion: The components of body composition differ according to diabetes type in adolescent girls. Measuring the body composition of diabetic girls might help to promote growth and adequate FFM gain during childhood. In diabetes control, diet and exercise should be emphasized along with insulin treatment.","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121998947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.135
Duk-Hee Kim
Received: 5 November, 2011, Accepted: 5 November, 2011 Address for correspondence: Duk Hee Kim M.D. Department of Pediatrics, Sowha Children's Hospital 224-32, Seogyel-dong, Yongsan-gu, Seoul 140-829, Korea Tel: +82.2-705-9112, Fax: +82.2-705-9000 E-mail: dhkim345@naver.com 여아 세 남아 세가 된다 사춘기동안 앉은 키 13 , 15 . (sitting 는척추와머리높이로여아에서 남아에서 height) 7.5 cm, 8.5 성장된다 하지 는 여아 남아 cm . (lower extremities) 7 cm, 8 성장된다 사춘기시작은신장치와앉은키를 개월간격 cm . 6 으로측정하여성장속도증가여부를찾아낼수있다 신장 . 이 여아에서 남아 되면 6 cm/year, 8 cm/year peak height 에도달하게된다 velocity 6-7) 또한성장속도가증가될때성 . 성숙도 가 단계가된다 이러한 (sexual maturation rate, SMR) 2 . 시기의 는여아 세 남아 세가된다 BA 11 , 13 .
2011年5月5日，Accepted: 5月5日，2011年Address for correspondence:Duk Hee Kim m.d. Department of Pediatrics, Sowha Children's Hospital 224-32, Seogyel-dong, Yongsan-gu, Seoul 140-829, Korea Tel: +82.2-705-9112, Fax: +82.2-705-9000 E-mail:dhkim345@naver.com女孩变成男孩，青春期期间坐着的身高13,15。(sitting是脊椎和头部的高度，从女婴到男婴的height)长7.5厘米，从男婴长8.5厘米。(lower extremities) 7厘米，成长8厘米青春期开始隐身装置和坐高间隔1个月cm。用6测定，可找出增长速度是否增加。velocity 6-7)在成长速度增加时也可达到6厘米/year, 8厘米/year peak height。成熟度达到阶段(sexual maturation rate, SMR) 2。时期是女婴和男婴。BA 11,13。
{"title":"Assessment of Bone Age During Pubertal Age","authors":"Duk-Hee Kim","doi":"10.6065/JKSPE.2011.16.3.135","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.135","url":null,"abstract":"Received: 5 November, 2011, Accepted: 5 November, 2011 Address for correspondence: Duk Hee Kim M.D. Department of Pediatrics, Sowha Children's Hospital 224-32, Seogyel-dong, Yongsan-gu, Seoul 140-829, Korea Tel: +82.2-705-9112, Fax: +82.2-705-9000 E-mail: dhkim345@naver.com 여아 세 남아 세가 된다 사춘기동안 앉은 키 13 , 15 . (sitting 는척추와머리높이로여아에서 남아에서 height) 7.5 cm, 8.5 성장된다 하지 는 여아 남아 cm . (lower extremities) 7 cm, 8 성장된다 사춘기시작은신장치와앉은키를 개월간격 cm . 6 으로측정하여성장속도증가여부를찾아낼수있다 신장 . 이 여아에서 남아 되면 6 cm/year, 8 cm/year peak height 에도달하게된다 velocity 6-7) 또한성장속도가증가될때성 . 성숙도 가 단계가된다 이러한 (sexual maturation rate, SMR) 2 . 시기의 는여아 세 남아 세가된다 BA 11 , 13 .","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"21 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131231398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.196
Ki Won Oh, J. Jeong, J. Kim
Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by recurrent paralysis of skeletal muscle and hypokalemia caused by a massive intracellular shift of potassium. TPP mainly affects young male patients of Asian descent. We describe a case of TPP in a 14-year-old girl who presented with palpitation and intermittent weakness of the lower extremities especially after physical exercises. The patient showed sinus tachycardia, proximal weakness of both legs and a severe hypokalemia. Thyroid function tests showed hyperthy- roidism, and thyroid scan revealed diffusely enlarged goiter consistent with Graves' disease. After the management with antithyroid drug, beta-adrenergic blocker and potassium supplementation for TPP, she has remained euthyroid state and symptom free on the follow-up. TPP should be considered in children with acute paralysis of skeletal muscle and hypokalemia, also thyroid function should be evaluated.
{"title":"A Case of Thyrotoxic Periodic Paralysis in Adolescent with Graves' Disease","authors":"Ki Won Oh, J. Jeong, J. Kim","doi":"10.6065/JKSPE.2011.16.3.196","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.196","url":null,"abstract":"Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by recurrent paralysis of skeletal muscle and hypokalemia caused by a massive intracellular shift of potassium. TPP mainly affects young male patients of Asian descent. We describe a case of TPP in a 14-year-old girl who presented with palpitation and intermittent weakness of the lower extremities especially after physical exercises. The patient showed sinus tachycardia, proximal weakness of both legs and a severe hypokalemia. Thyroid function tests showed hyperthy- roidism, and thyroid scan revealed diffusely enlarged goiter consistent with Graves' disease. After the management with antithyroid drug, beta-adrenergic blocker and potassium supplementation for TPP, she has remained euthyroid state and symptom free on the follow-up. TPP should be considered in children with acute paralysis of skeletal muscle and hypokalemia, also thyroid function should be evaluated.","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"1 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120821690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.193
Seul Lee, A. Kwon, H. Chae, Ho-Seong Kim
Hypomagnesemia may arise from various disorders such as renal magnesium wasting, familial hypomagnesemia, inadequate intake and increased gastrointestinal loss. Hypomagnesemia and hypocalcemia were found in a month- old female patient with generalized tonic-clonic seizure. Twenty-four hour urine collection samples were used to assess renal magnesium wasting; fractional excretion of 24-hr urine magnesium was less than 1.45%, i.e., within the normal limits. The patient had no history of chronic diarrhea or failure to thrive, which supports the conclusion that intake was adequate. She had no family history of hypocalcemia, hypomagnesemia, or seizures. Here, we report a case of idiopathic hypomagnesemia.
{"title":"A Case of Idiopathic Hypomagnesemia with Hypocalcemia Presenting as Generalized Tonic-Clonic Seizure","authors":"Seul Lee, A. Kwon, H. Chae, Ho-Seong Kim","doi":"10.6065/JKSPE.2011.16.3.193","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.193","url":null,"abstract":"Hypomagnesemia may arise from various disorders such as renal magnesium wasting, familial hypomagnesemia, inadequate intake and increased gastrointestinal loss. Hypomagnesemia and hypocalcemia were found in a month- old female patient with generalized tonic-clonic seizure. Twenty-four hour urine collection samples were used to assess renal magnesium wasting; fractional excretion of 24-hr urine magnesium was less than 1.45%, i.e., within the normal limits. The patient had no history of chronic diarrhea or failure to thrive, which supports the conclusion that intake was adequate. She had no family history of hypocalcemia, hypomagnesemia, or seizures. Here, we report a case of idiopathic hypomagnesemia.","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117200436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.165
J. Yoon, M. Kang, S. Y. Kim, J. Seo, S. Yang, Y. Lee, Jieun Lee, H. Chung, C. Shin
The Relationship between Initial Body Mass Index and Body Mass Index after One Year of Gonadotropin-Releasing Hormone Agonist Therapy in Idiopathic True Precocious Puberty Girls Ju Young Yoon, M.D., Min Jae Kang, M.D., Se Young Kim, M.D., Ji Young Seo, M.D., Sei Won Yang, M.D., Young Ah Lee, M.D., Ji Eun Lee, M.D., Hye Rim Chung, M.D and Choong Ho Shin, M.D. Department of Pediatrics , Seoul National University College of Medicine, Seoul, Department of Pediatrics, Bundang Jesaeng General Hospital, Seongnam, Department of Pediatrics, Eulji University School of Medicine, Seoul, Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea
{"title":"The Relationship between Initial Body Mass Index and Body Mass Index after One Year of Gonadotropin-Releasing Hormone Agonist Therapy in Idiopathic True Precocious Puberty Girls","authors":"J. Yoon, M. Kang, S. Y. Kim, J. Seo, S. Yang, Y. Lee, Jieun Lee, H. Chung, C. Shin","doi":"10.6065/JKSPE.2011.16.3.165","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.165","url":null,"abstract":"The Relationship between Initial Body Mass Index and Body Mass Index after One Year of Gonadotropin-Releasing Hormone Agonist Therapy in Idiopathic True Precocious Puberty Girls Ju Young Yoon, M.D., Min Jae Kang, M.D., Se Young Kim, M.D., Ji Young Seo, M.D., Sei Won Yang, M.D., Young Ah Lee, M.D., Ji Eun Lee, M.D., Hye Rim Chung, M.D and Choong Ho Shin, M.D. Department of Pediatrics , Seoul National University College of Medicine, Seoul, Department of Pediatrics, Bundang Jesaeng General Hospital, Seongnam, Department of Pediatrics, Eulji University School of Medicine, Seoul, Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126594863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pamidronate Treatment in 9-Year-Old Boy Diagnosed with Gorham Disease","authors":"J. Yoon, Jieun Lee, Seung Wan Park, M. Kang, Y. Lee, S. Yang, K. Park, C. Shin","doi":"10.6065/JKSPE.2011.16.3.189","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.189","url":null,"abstract":"병은뼈에서의비정상적인혈관증식으로인한골 Gorham 용해를 특징으로하는질환이다 주 증상은골 소실로 인한 . 골절이나유미흉 혈흉등이있으며 주된침범부위는상악 , , 골 어깨뼈 늑골 골반뼈등이다 , , , 1) 등 . Heffez 2) 은 병 Gorham 의진단기준으로 생검소견상혈관종성조직소견 비 1) , 2) 정형세포가없을것 신생골형성이나이영양성석회화가 , 3) 없을것 진행되는국소성골용해소견 비증식성 비궤 , 4) , 5) , 양성병변 내부장기의침범이없을것 방사선학적으 , 6) , 7) 로골용해소견이보일것 유전적인대사이상 면역학적 , 8) , 이상 악성종양이나 감염이 없을 것 등을 제시하였다 , . Gor병은현재까지약 예가보고된드문질환으로 발병 ham 200 원인과그기전은밝혀져있지않으며적립된치료법도없다. 이에저자들은 세에 병으로진단받은남아에서파 9 Gorham 미드로네이트 치료 후 성공적으로 질병 활동성이 안정화되","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124001209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.157
Kee Hyoung Lee, B. Lee, C. Ko, D. Jin, S. Yang, H. Yoo, W. Chung, Duk-Hee Kim, Byung-Kyu Suh
Department of Pediatrics, Korea University Hospital, Department of Pediatrics, The Catholic University St. Mary s Hospital, Seoul, ’ Department of Pediatrics, Kyungpook National University Hospital, Daegu, Department of Pediatrics, Samsung Medical Center, Department of Pediatrics, Seoul National University Children's Hospital, Department of Pediatrics, Asan Medical Center, Seoul, Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Department of Pediatrics, Severance Hospital, Department of Pediatrics, The Catholic University Seoul St. Mary s Hospital, Seoul, Korea ’
{"title":"A Single-Arm, Phase III Study to Assess Efficacy and Safety after 6-Month-Treatment of Eutropin™ Inj. (Recombinant Human Growth Hormone) in Prepubertal Children with Short Stature due to Small for Gestational Age","authors":"Kee Hyoung Lee, B. Lee, C. Ko, D. Jin, S. Yang, H. Yoo, W. Chung, Duk-Hee Kim, Byung-Kyu Suh","doi":"10.6065/JKSPE.2011.16.3.157","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.157","url":null,"abstract":"Department of Pediatrics, Korea University Hospital, Department of Pediatrics, The Catholic University St. Mary s Hospital, Seoul, ’ Department of Pediatrics, Kyungpook National University Hospital, Daegu, Department of Pediatrics, Samsung Medical Center, Department of Pediatrics, Seoul National University Children's Hospital, Department of Pediatrics, Asan Medical Center, Seoul, Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Department of Pediatrics, Severance Hospital, Department of Pediatrics, The Catholic University Seoul St. Mary s Hospital, Seoul, Korea ’","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122041934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.178
Jieun Lee, J. Yoon, Y. Lee, J. Lim, C. Shin, S. Yang
Purpose: The aim of this study was to evaluate the efficacy of pamidronate therapy in children and adolescents with secondary osteoporosis. Methods: Nine patients (7 males, 2 females, 13.2 ± 2.5 years, 10.1-17.4 years) with secondary osteoporosis who had a history of severe bone pain and/or fracture were enrolled. Intravenous pamidronate 1.5 mg/kg (0.5 mg/kg for 3 consecutive days) was given every 6 to 8 weeks for 0.86 ± 0.15 years (6 or 8 cycles). Bone mineral density (BMD) in lumbar spine and femoral neck and their Z-scores were measured before treatment, after the fourth and last cycle (sixth or eighth cycle). Results: Underlying diseases were as follows; neurofibromatosis type 1 (n = 2), epilepsy with/without cerebral palsy (N=2), autoimmune disease treated with steroid (n = 2), hematologic malignancy (n = 3). Bone pain was relieved in most of the patients after the first cycle of treatment, and no more fracture occurred thereafter. There was a significant increase in BMD Z-score of the lumbar spine and femoral neck after the last cycle of therapy, compared to baseline values (from -3.91 ± 1.79 to 1.86 ± 1.18, in L1-4 and -3.71 ± 1.83 to -2.53 ± 1.77 for femoral neck; P = 0.008 and 0.011, respectively). However, there was no significant change in BMD Z-scores between the fourth cycle and the last cycle. Fever developed in 7 out of 9 patients (77.8%), which was relieved by antipyretics. Total serum levels of calcium and phosphorus were significantly decreased (calcium, P = 0.008; phosphorus, P = 0.015) after pamidronate therapy, and three of them experienced symptomatic hypocalcemia during the first cycle. The growth velocity was normal during follow-up periods (mean, 4.47 ± 1.69 years; range, 1.05 to 6.77 years). Conclusion: In conclusion, pamidronate can be administered to the patients with secondary osteoporosis, relieving the symptoms and signs effectively and safely. However, its side effects should be monitored during treatment.
{"title":"Pamidronate Therapy in Children and Adolescents with Secondary Osteoporosis","authors":"Jieun Lee, J. Yoon, Y. Lee, J. Lim, C. Shin, S. Yang","doi":"10.6065/JKSPE.2011.16.3.178","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.178","url":null,"abstract":"Purpose: The aim of this study was to evaluate the efficacy of pamidronate therapy in children and adolescents with secondary osteoporosis. Methods: Nine patients (7 males, 2 females, 13.2 ± 2.5 years, 10.1-17.4 years) with secondary osteoporosis who had a history of severe bone pain and/or fracture were enrolled. Intravenous pamidronate 1.5 mg/kg (0.5 mg/kg for 3 consecutive days) was given every 6 to 8 weeks for 0.86 ± 0.15 years (6 or 8 cycles). Bone mineral density (BMD) in lumbar spine and femoral neck and their Z-scores were measured before treatment, after the fourth and last cycle (sixth or eighth cycle). Results: Underlying diseases were as follows; neurofibromatosis type 1 (n = 2), epilepsy with/without cerebral palsy (N=2), autoimmune disease treated with steroid (n = 2), hematologic malignancy (n = 3). Bone pain was relieved in most of the patients after the first cycle of treatment, and no more fracture occurred thereafter. There was a significant increase in BMD Z-score of the lumbar spine and femoral neck after the last cycle of therapy, compared to baseline values (from -3.91 ± 1.79 to 1.86 ± 1.18, in L1-4 and -3.71 ± 1.83 to -2.53 ± 1.77 for femoral neck; P = 0.008 and 0.011, respectively). However, there was no significant change in BMD Z-scores between the fourth cycle and the last cycle. Fever developed in 7 out of 9 patients (77.8%), which was relieved by antipyretics. Total serum levels of calcium and phosphorus were significantly decreased (calcium, P = 0.008; phosphorus, P = 0.015) after pamidronate therapy, and three of them experienced symptomatic hypocalcemia during the first cycle. The growth velocity was normal during follow-up periods (mean, 4.47 ± 1.69 years; range, 1.05 to 6.77 years). Conclusion: In conclusion, pamidronate can be administered to the patients with secondary osteoporosis, relieving the symptoms and signs effectively and safely. However, its side effects should be monitored during treatment.","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131054926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-12-01DOI: 10.6065/JKSPE.2011.16.3.185
Jeoung Suk Kim, Min Sun Kim, Sun Jun Kim, G. Chung, P. Hwang, Dae-Yeol Lee
Pituitary enlargement secondary to primary hypothyroidism is a known but uncommon occurrence and is difficult to distinguish on computed tomography (CT) and magnetic resonance imaging (MRI) from primary pituitary tumor. The lack of thyroxine feedback found in uncontrolled primary hypothyroidism leads to elevated levels of thyrotropin-releasing hormone (TRH), which causes both pituitary thyrotroph and lactotroph hyperplasia, increasing the secretion of both thyroidstimulating hormone (TSH) and prolactin. With long-standing hypothyroidism, thyrotroph hyperplasia can result in expansion of the sella turcica and enlargement of the pituitary gland. Pituitary hyperplasia usually regresses following adequate treatment with hormone replacement over a period of a few months. We herein report a case of pituitary hyperplasia associated with hypothyroidism in a short statured female adolescent without the typical clinical features associated with hypothy-
{"title":"Pituitary Hyperplasia Secondary to Hypothyroidism Caused by Hashimoto's Thyroiditis in a Female Adolescent","authors":"Jeoung Suk Kim, Min Sun Kim, Sun Jun Kim, G. Chung, P. Hwang, Dae-Yeol Lee","doi":"10.6065/JKSPE.2011.16.3.185","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.3.185","url":null,"abstract":"Pituitary enlargement secondary to primary hypothyroidism is a known but uncommon occurrence and is difficult to distinguish on computed tomography (CT) and magnetic resonance imaging (MRI) from primary pituitary tumor. The lack of thyroxine feedback found in uncontrolled primary hypothyroidism leads to elevated levels of thyrotropin-releasing hormone (TRH), which causes both pituitary thyrotroph and lactotroph hyperplasia, increasing the secretion of both thyroidstimulating hormone (TSH) and prolactin. With long-standing hypothyroidism, thyrotroph hyperplasia can result in expansion of the sella turcica and enlargement of the pituitary gland. Pituitary hyperplasia usually regresses following adequate treatment with hormone replacement over a period of a few months. We herein report a case of pituitary hyperplasia associated with hypothyroidism in a short statured female adolescent without the typical clinical features associated with hypothy-","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115038310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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