Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.86
Min jeong Kim, H. Jung, I. Choi, S. Hong
Purpose: There are few reports about the natural history of patients with pseudoprecocious puberty due to autonomous ovarian cyst. We reviewed the clinical course of 7 patients who had autonomous ovarian cysts and signs of precocious puberty. Methods:We retrospectively evaluated 7 children, aged 2.8 to 7.9 years, who were diagnosed with pseudoprecocious puberty due to autonomous ovarian cysts from November 2005 to May 2011. The follow-up durations ranged from 0.5 to 6.3 years. Results: Four out of 7 patients showed elevated serum estrogen levels and all revealed prepubertal response of gonadotropin to GnRH stimulation at diagnosis. The size of the cysts was from 1.7 to 4.6 cm on pelvic ultrasound examination. After 1 to 3 months, the ovarian cysts disappeared in all patients. Three of the girls developed relapsing signs of precocious puberty (vaginal bleeding and breast budding). Two of them showed an increase in growth velocity and bone age due to recurrent ovarian cysts, and one of them was converted to true precocious puberty. Conclusion: In our cases, all patients with autonomous ovarian cysts resolved spontaneously. However, some showed frequent recurrence of ovarian cysts, and needed a longer follow up because of the possibility of conversion to true precocious puberty and signs of McCune-Albright syndrome. (J Korean Soc Pediatr Endocrinol 2011;16: 86-91)
{"title":"Clinical Course of Childhood Onset Pseudoprecocious Puberty due to Autonomous Ovarian Cyst","authors":"Min jeong Kim, H. Jung, I. Choi, S. Hong","doi":"10.6065/JKSPE.2011.16.2.86","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.86","url":null,"abstract":"Purpose: There are few reports about the natural history of patients with pseudoprecocious puberty due to autonomous ovarian cyst. We reviewed the clinical course of 7 patients who had autonomous ovarian cysts and signs of precocious puberty. Methods:We retrospectively evaluated 7 children, aged 2.8 to 7.9 years, who were diagnosed with pseudoprecocious puberty due to autonomous ovarian cysts from November 2005 to May 2011. The follow-up durations ranged from 0.5 to 6.3 years. Results: Four out of 7 patients showed elevated serum estrogen levels and all revealed prepubertal response of gonadotropin to GnRH stimulation at diagnosis. The size of the cysts was from 1.7 to 4.6 cm on pelvic ultrasound examination. After 1 to 3 months, the ovarian cysts disappeared in all patients. Three of the girls developed relapsing signs of precocious puberty (vaginal bleeding and breast budding). Two of them showed an increase in growth velocity and bone age due to recurrent ovarian cysts, and one of them was converted to true precocious puberty. Conclusion: In our cases, all patients with autonomous ovarian cysts resolved spontaneously. However, some showed frequent recurrence of ovarian cysts, and needed a longer follow up because of the possibility of conversion to true precocious puberty and signs of McCune-Albright syndrome. (J Korean Soc Pediatr Endocrinol 2011;16: 86-91)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130093630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.119
Jiyun Park, Jong Seok Oh, Jeesuk Yu
The present research was conducted by the research fund of Dankook University in 2010. Received: 2 August, 2011, Revised: 12 August, 2011 Accepted: 25 August, 2011 Address for correspondence: Jeesuk Yu, M.D., Ph.D. Department of Pediatrics, Dankook University College of Medicine, Anseo-dong, dongnam-gu, Cheonan 330-714, Korea Tel: +82.41.550-3938, Fax: +82.41.565-6167 E-mail: dryujs@yahoo.co.kr 병이 형이었으나 최근소아에서의 형당뇨병또한늘어나 1 , 2
{"title":"Autoantibody Positivity and Clinical Characteristics of Diabetes Mellitus in Childhood","authors":"Jiyun Park, Jong Seok Oh, Jeesuk Yu","doi":"10.6065/JKSPE.2011.16.2.119","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.119","url":null,"abstract":"The present research was conducted by the research fund of Dankook University in 2010. Received: 2 August, 2011, Revised: 12 August, 2011 Accepted: 25 August, 2011 Address for correspondence: Jeesuk Yu, M.D., Ph.D. Department of Pediatrics, Dankook University College of Medicine, Anseo-dong, dongnam-gu, Cheonan 330-714, Korea Tel: +82.41.550-3938, Fax: +82.41.565-6167 E-mail: dryujs@yahoo.co.kr 병이 형이었으나 최근소아에서의 형당뇨병또한늘어나 1 , 2","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121065165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.112
Y. Yi, Jung Kyung Yoo, H. K. Park, Seung Yang, I. Hwang
Purpose: The aim of the study was to investigate postnatal changes in growth and insulin, leptin, IGF-I, adiponectin, and ghrelin, and to examine the relationship of these hormones with catch-up growth in full-term small for gestational age (SGA) infants. Methods: SGA was defined as a birth weight less than the ten percentile. Weight and height were measured at birth, 1 month, 6 months, 1 year, and 2 years of age in 70 SGA infants (40 females and 30 males). The infants were subdivided according to their weight and height catch-up growth (CUG) at 2 years old. CUG is defined as reaching a standard deviation score (SDS) of -2 SDS. Blood samples were serially taken for insulin, leptin, insulin- ˃ like growth factor (IGF)-I, adiponectin, and ghrelin. Results: 1) Dramatic CUG for weight and height occurred during the first year of life; weight and height growth gain decreased thereafter. 2) Non-catch-up growth (NCUG) infants showed more decreased weight and height growth gain than CUG infants between the first and second year of life. 3) Weight CUG was 77.1% and height CUG was 75.8% in the SGA infants. 4) Weight CUG infants showed significantly higher leptin and ghrelin levels than in weight NCUG infants at the age of 1 year (P 0.05). 5) Height CUG infants showed significantly higher ˂ leptin and ghrelin levels than in height NCUG infants at the age of 1 year (P 0.05). ˂ Conclusion: CUG for weight and height occurred during the first year of life and growth velocity decreased thereafter. Significant corresponding changes occurred with regard to serum leptin and ghrelin. (J Korean Soc Pediatr Endocrinol 2011;16:112-118)
{"title":"Relationship between Catch-up Growth and Changes in Insulin, Leptin, IGF-I, Adiponectin, and Ghrelin in Infants Born Full-term Small for Gestational Age","authors":"Y. Yi, Jung Kyung Yoo, H. K. Park, Seung Yang, I. Hwang","doi":"10.6065/JKSPE.2011.16.2.112","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.112","url":null,"abstract":"Purpose: The aim of the study was to investigate postnatal changes in growth and insulin, leptin, IGF-I, adiponectin, and ghrelin, and to examine the relationship of these hormones with catch-up growth in full-term small for gestational age (SGA) infants. Methods: SGA was defined as a birth weight less than the ten percentile. Weight and height were measured at birth, 1 month, 6 months, 1 year, and 2 years of age in 70 SGA infants (40 females and 30 males). The infants were subdivided according to their weight and height catch-up growth (CUG) at 2 years old. CUG is defined as reaching a standard deviation score (SDS) of -2 SDS. Blood samples were serially taken for insulin, leptin, insulin- ˃ like growth factor (IGF)-I, adiponectin, and ghrelin. Results: 1) Dramatic CUG for weight and height occurred during the first year of life; weight and height growth gain decreased thereafter. 2) Non-catch-up growth (NCUG) infants showed more decreased weight and height growth gain than CUG infants between the first and second year of life. 3) Weight CUG was 77.1% and height CUG was 75.8% in the SGA infants. 4) Weight CUG infants showed significantly higher leptin and ghrelin levels than in weight NCUG infants at the age of 1 year (P 0.05). 5) Height CUG infants showed significantly higher ˂ leptin and ghrelin levels than in height NCUG infants at the age of 1 year (P 0.05). ˂ Conclusion: CUG for weight and height occurred during the first year of life and growth velocity decreased thereafter. Significant corresponding changes occurred with regard to serum leptin and ghrelin. (J Korean Soc Pediatr Endocrinol 2011;16:112-118)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125208983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.92
Hyeon Jeong Lee, Bong Sub Song, Dong Hwan Kim, Seung Youn Kim, J. Cho, Dong Ho Kim, J. Lee, J. Lim
Purpose: To obtain normative data on bone mineral density of each region of interest (ROI) measured by Hologic model dual-energy x-ray absorptiometry (DXA) of children and adolescents. Methods: Cross sectional results from 723 healthy Korean children and adolescents (10-20 years of age) in the Korean National Health and Nutrition Examination Surveys were analyzed. We used age- and sex-specific reference data for bone mineral density (BMD) of the lumbar spine, femur neck, and total body except head from Hologic DXA device as recommended by the International Society for Clinical Densitometry. Results: The bone mineral density of each ROI increased with age in both boys and girls. Maximal increase in the lumbar BMD occurred between ages 11 and 12 in girls and between ages 12 and 14 in boys. However, the increases of BMD in each ROI were different. The plateaus of the lumbar spine and whole body except head BMD in girls occurred at ages 15 and 17, respectively. The plateaus of BMD in each ROI occurred at age 17 in boys. Conclusion: Most of the skeletal mass, including lumbar spine and total body except head, is reached before the end of the second decade. This study provides reference values for bone density of each ROI measured with DXA for children and adolescents. (J Korean Soc Pediatr Endocrinol 2011;16:92-99)
{"title":"Bone Mineral Density Reference of 10-20 year-old Korean Children and Adolescents - Based on Hologic DXA from the Korean National Health and Nutrition Examination Surveys -","authors":"Hyeon Jeong Lee, Bong Sub Song, Dong Hwan Kim, Seung Youn Kim, J. Cho, Dong Ho Kim, J. Lee, J. Lim","doi":"10.6065/JKSPE.2011.16.2.92","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.92","url":null,"abstract":"Purpose: To obtain normative data on bone mineral density of each region of interest (ROI) measured by Hologic model dual-energy x-ray absorptiometry (DXA) of children and adolescents. Methods: Cross sectional results from 723 healthy Korean children and adolescents (10-20 years of age) in the Korean National Health and Nutrition Examination Surveys were analyzed. We used age- and sex-specific reference data for bone mineral density (BMD) of the lumbar spine, femur neck, and total body except head from Hologic DXA device as recommended by the International Society for Clinical Densitometry. Results: The bone mineral density of each ROI increased with age in both boys and girls. Maximal increase in the lumbar BMD occurred between ages 11 and 12 in girls and between ages 12 and 14 in boys. However, the increases of BMD in each ROI were different. The plateaus of the lumbar spine and whole body except head BMD in girls occurred at ages 15 and 17, respectively. The plateaus of BMD in each ROI occurred at age 17 in boys. Conclusion: Most of the skeletal mass, including lumbar spine and total body except head, is reached before the end of the second decade. This study provides reference values for bone density of each ROI measured with DXA for children and adolescents. (J Korean Soc Pediatr Endocrinol 2011;16:92-99)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134074338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.106
S. Bauer, Hyo-Kyoung Nam, Y. Rhie, Sang Hee Park, K. Lee
Purpose: The objective of this study was to evaluate the effect of gonadotropin releasing hormone analog (GnRHa) treatment on bone mineral density (BMD) in girls with central precocious puberty (CPP). Further we investigated the differences in the effect on BMD by using the GnRHa leuprolide-acetate and triptorelin. Methods: Sixty-one females with CPP were enrolled in the study, the lumbar spine BMD was measured by dual energy x-ray absorptiometry before treatment, after one year (n = 61) and after two years (n = 24) of treatment. Lumbar spine BMD standard deviation scores (SDS) were compared according to chronological age (CA) and bone age (BA) for the whole group, as well as for the group A, treated with leuprolide-acetate (n = 40), and the group B, treated with triptorelin (n = 21). Results: All subjects showed significant increment in BMD during treatment (P ˂ 0.05). Lumbar spine BMD SDS for CA and BA showed no significant changes before and during treatment. Group A and group B, within each group, showed no significant changes in lumbar spine BMD SDS for CA and BA during treatment. Conclusion: Our study suggests that lumbar spine BMD was not impaired in girls treated with GnRHa for CPP and both leuprolide-acetate and triptorelin showed comparable effects on lumbar spine BMD during treatment. (J Korean Soc Pediatr Endocrinol 2011;16:106-111)
{"title":"Effect of GnRH Analogs Leuprolide-Acetate and Triptorelin on Bone Mineral Density in Girls with Central Precocious Puberty","authors":"S. Bauer, Hyo-Kyoung Nam, Y. Rhie, Sang Hee Park, K. Lee","doi":"10.6065/JKSPE.2011.16.2.106","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.106","url":null,"abstract":"Purpose: The objective of this study was to evaluate the effect of gonadotropin releasing hormone analog (GnRHa) treatment on bone mineral density (BMD) in girls with central precocious puberty (CPP). Further we investigated the differences in the effect on BMD by using the GnRHa leuprolide-acetate and triptorelin. Methods: Sixty-one females with CPP were enrolled in the study, the lumbar spine BMD was measured by dual energy x-ray absorptiometry before treatment, after one year (n = 61) and after two years (n = 24) of treatment. Lumbar spine BMD standard deviation scores (SDS) were compared according to chronological age (CA) and bone age (BA) for the whole group, as well as for the group A, treated with leuprolide-acetate (n = 40), and the group B, treated with triptorelin (n = 21). Results: All subjects showed significant increment in BMD during treatment (P ˂ 0.05). Lumbar spine BMD SDS for CA and BA showed no significant changes before and during treatment. Group A and group B, within each group, showed no significant changes in lumbar spine BMD SDS for CA and BA during treatment. Conclusion: Our study suggests that lumbar spine BMD was not impaired in girls treated with GnRHa for CPP and both leuprolide-acetate and triptorelin showed comparable effects on lumbar spine BMD during treatment. (J Korean Soc Pediatr Endocrinol 2011;16:106-111)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130628773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.80
Jun Hyeon Shin, W. Hu, I. Hwang, Seung Yang
Purpose: The aim of this study was to assess the usefulness of growth velocity at 3 months after gonadotropin- releasing hormone (GnRH) agonist treatment as a predictive value of 1 year growth velocity after treatment in girls with precocious puberty. Methods: We studied 30 Korean girls with precocious puberty whose chronologic and bone age were less than 9 years and 11 years old, respectively at diagnosis. They treated with a 4 week interval GnRH agonist subcutaneous injections for at least more than 1 year. The patients who were treated with growth hormone simultaneously exclu- ded for this study. Data were collected from chart review retrospectively. We measured heights and calculated growth velocities of the subjects at 3 months and 1 year after GnRH agonist treatment. Results: The mean chronologic age and bone age of the subjects were 8.3 ± 0.8 year and 10.4 ± 0.6 years, respec- tively. The growth velocity at 3 months, 6 months, 9 months and 1 year after GnRH agonist treatment were 7.1 ± 2.6, 6.6 ± 2.1, 5.7 ± 1.3 and 5.8 ± 0.9 cm/yr, respectively. The positive correlation between the growth velocity at 3 months and 6 months, 9 months, 1 year after GnRH agonist treatment were shown(P ˂ 0.001, P ˂ 0.001, P = 0.002, respectively). Conclusion: In this study, the growth velocity at 1 year after GnRH agonist treatment may be predicted by the growth velocity at 3 months after treatment. The patient whose growth velocity at 3 months after GnRH agnoist treatment was low would be needed to observe the growth pattern carefully and to consider combined growth hormone treatment, if needed. It may be deserve further studies to improve final height in patients with central precocious puberty in various conditions. (J Korean Soc Pediatr Endocrinol 2011;16:80-85)
{"title":"Prediction of 1 Year Growth in Girls with Precocious Puberty with GnRH Agonist Treatment by Measurement of Growth Velocity at 3 Months after Treatment","authors":"Jun Hyeon Shin, W. Hu, I. Hwang, Seung Yang","doi":"10.6065/JKSPE.2011.16.2.80","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.80","url":null,"abstract":"Purpose: The aim of this study was to assess the usefulness of growth velocity at 3 months after gonadotropin- releasing hormone (GnRH) agonist treatment as a predictive value of 1 year growth velocity after treatment in girls with precocious puberty. Methods: We studied 30 Korean girls with precocious puberty whose chronologic and bone age were less than 9 years and 11 years old, respectively at diagnosis. They treated with a 4 week interval GnRH agonist subcutaneous injections for at least more than 1 year. The patients who were treated with growth hormone simultaneously exclu- ded for this study. Data were collected from chart review retrospectively. We measured heights and calculated growth velocities of the subjects at 3 months and 1 year after GnRH agonist treatment. Results: The mean chronologic age and bone age of the subjects were 8.3 ± 0.8 year and 10.4 ± 0.6 years, respec- tively. The growth velocity at 3 months, 6 months, 9 months and 1 year after GnRH agonist treatment were 7.1 ± 2.6, 6.6 ± 2.1, 5.7 ± 1.3 and 5.8 ± 0.9 cm/yr, respectively. The positive correlation between the growth velocity at 3 months and 6 months, 9 months, 1 year after GnRH agonist treatment were shown(P ˂ 0.001, P ˂ 0.001, P = 0.002, respectively). Conclusion: In this study, the growth velocity at 1 year after GnRH agonist treatment may be predicted by the growth velocity at 3 months after treatment. The patient whose growth velocity at 3 months after GnRH agnoist treatment was low would be needed to observe the growth pattern carefully and to consider combined growth hormone treatment, if needed. It may be deserve further studies to improve final height in patients with central precocious puberty in various conditions. (J Korean Soc Pediatr Endocrinol 2011;16:80-85)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115401356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.73
M. Jung
Endocrine disorders develop commonly in preterm neonates and critically ill neonates. Preterm newborns have im- mature endocrine system as well as immature organs. Their adaptation to extrauterine life might be more challeng- ing and more unfavorable. The most common endocrine disorders in the sick and preterm newborn are thyroid disorders, hypocalcemia, adrenal insufficiency and disorders of glucose metabolism. To detect the endocrine pro- blems appropriately and to find best approaches to them, pediatric neonatologists and endocrinologists should be well aware of the epidemiology, pathophysiology, clinical characteristics and effective management of common endocrine disorders in the sick and preterm newborns. (J Korean Soc Pediatr Endocrinol 2011;16:73-79)
{"title":"Endocrine Disorders in the Sick and Preterm Newborn","authors":"M. Jung","doi":"10.6065/JKSPE.2011.16.2.73","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.73","url":null,"abstract":"Endocrine disorders develop commonly in preterm neonates and critically ill neonates. Preterm newborns have im- mature endocrine system as well as immature organs. Their adaptation to extrauterine life might be more challeng- ing and more unfavorable. The most common endocrine disorders in the sick and preterm newborn are thyroid disorders, hypocalcemia, adrenal insufficiency and disorders of glucose metabolism. To detect the endocrine pro- blems appropriately and to find best approaches to them, pediatric neonatologists and endocrinologists should be well aware of the epidemiology, pathophysiology, clinical characteristics and effective management of common endocrine disorders in the sick and preterm newborns. (J Korean Soc Pediatr Endocrinol 2011;16:73-79)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131748608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.128
S. H. Jee, Eun Young Kim
Acute suppurative thyroiditis is an uncommon condition because the thyroid gland is remarkably resistant to infec- tion. In children, anatomic defects, such as a left piriform sinus fistula, predispose subjects to this infection. It is very important yet difficult to differentiate acute thyroiditis with thyrotoxicosis from subacute thyroiditis; and if left untreated, acute suppurative thyroiditis can lead to thyroid abscess formation. Bacterial infections with staphylococ- cus and streptococcus species are the most common causes of acute suppurative thyroiditis. Occasionally, the thyroid gland can be infected with fungi, parasites, or mycobacterium. An 8-year-old boy presented with acute fever and tender neck swelling. The patient was admitted to the hospital and was diagnosed with acute suppurative thyroiditis. The culture result of the drained fluid revealed methicillin-resistant staphylococcus aureus (MRSA). The patient's condition improved after the use of antibiotics and drainage. There was no evidence of fistula formation between the thyroid and the pyriform sinus on a computed tomography (CT) scan. Here we describe rapidly progressive thyroid abscesses caused by MRSA in healthy children. (J Korean Soc Pediatr Endocrinol 2011;16: 128-132)
{"title":"Acute Suppurative Thyroiditis Caused by Methicillin - Resistant Staphylococcus Aureus in Healthy Children","authors":"S. H. Jee, Eun Young Kim","doi":"10.6065/JKSPE.2011.16.2.128","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.128","url":null,"abstract":"Acute suppurative thyroiditis is an uncommon condition because the thyroid gland is remarkably resistant to infec- tion. In children, anatomic defects, such as a left piriform sinus fistula, predispose subjects to this infection. It is very important yet difficult to differentiate acute thyroiditis with thyrotoxicosis from subacute thyroiditis; and if left untreated, acute suppurative thyroiditis can lead to thyroid abscess formation. Bacterial infections with staphylococ- cus and streptococcus species are the most common causes of acute suppurative thyroiditis. Occasionally, the thyroid gland can be infected with fungi, parasites, or mycobacterium. An 8-year-old boy presented with acute fever and tender neck swelling. The patient was admitted to the hospital and was diagnosed with acute suppurative thyroiditis. The culture result of the drained fluid revealed methicillin-resistant staphylococcus aureus (MRSA). The patient's condition improved after the use of antibiotics and drainage. There was no evidence of fistula formation between the thyroid and the pyriform sinus on a computed tomography (CT) scan. Here we describe rapidly progressive thyroid abscesses caused by MRSA in healthy children. (J Korean Soc Pediatr Endocrinol 2011;16: 128-132)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125102174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.6065/JKSPE.2011.16.2.100
S. Lee, A. Kwon, H. Chae, Ho-Seong Kim
Purpose: Noonan syndrome (NS) is characterized by short stature, congenital heart defects, mild mental retardation, and characteristic faces. We investigated the efficacy of growth hormone (GH) treatment and the adverse effect compared to sex and age-matched patients with growth hormone deficiency (GHD). Methods: We included patients whose Noonan scores were over 60, treated with GH in Severance Children's Hospital. We analyzed height and height velocity before and during GH treatment in 14 NS patients (0.81 ± 0.13 U/kg/wk) and also in 42 patients with sex- and age-matched GHD as a control group (0.78 ± 0.17 U/kg/wk) at intervals of 3 months. Results: At the start of GH treatment, mean age was 10.0 ± 2.4 years, and mean height was 123.3 ± 13.5 cm, and the height SDS was -2.79 ± 0.85 in NS, while the mean age was 10.3 ± 2.6 years, mean height was 119.6 ± 13.5 cm, and the height SDS was -3.43 ± 1.56 in GHD. Mean duration was 3.8 ± 2.1 years in NS and 4.9 ± 2.4 years in GHD. Mean height SDS increased from -2.79 SDS to -1.94 SDS in NS (P = 0.007) and from -3.43 SDS to -1.82 SDS in GHD (P ˂ 0.0001). Growth velocity increased from 3.7 ± 1.2 cm/yr to 8.5 ± 2.5 cm/yr (P ˂ 0.0001) and 6.5 ± 2.9 cm/yr (P = 0.016) during the first and second years of GH treatment, respectively, in NS and from 3.4 ± 1.5 cm/yr to 8.8 ± 2.3 cm/yr (P ˂ 0.0001) and 8.1 ± 3.2 cm/yr (P ˂ 0.0001) in GHD. No severe adverse effects were observed during treatment. Conclusion: GH treatment in the NS patients increased growth velocity significantly, especially during the 1 st year of treatment. GH treatment in NS is thought to be effective and relatively safe. (J Korean Soc Pediatr Endocrinol 2011;16:100-105)
{"title":"Efficacy of Growth Hormone Treatment in Patients with Noonan syndrome and Growth Hormone Deficiency","authors":"S. Lee, A. Kwon, H. Chae, Ho-Seong Kim","doi":"10.6065/JKSPE.2011.16.2.100","DOIUrl":"https://doi.org/10.6065/JKSPE.2011.16.2.100","url":null,"abstract":"Purpose: Noonan syndrome (NS) is characterized by short stature, congenital heart defects, mild mental retardation, and characteristic faces. We investigated the efficacy of growth hormone (GH) treatment and the adverse effect compared to sex and age-matched patients with growth hormone deficiency (GHD). Methods: We included patients whose Noonan scores were over 60, treated with GH in Severance Children's Hospital. We analyzed height and height velocity before and during GH treatment in 14 NS patients (0.81 ± 0.13 U/kg/wk) and also in 42 patients with sex- and age-matched GHD as a control group (0.78 ± 0.17 U/kg/wk) at intervals of 3 months. Results: At the start of GH treatment, mean age was 10.0 ± 2.4 years, and mean height was 123.3 ± 13.5 cm, and the height SDS was -2.79 ± 0.85 in NS, while the mean age was 10.3 ± 2.6 years, mean height was 119.6 ± 13.5 cm, and the height SDS was -3.43 ± 1.56 in GHD. Mean duration was 3.8 ± 2.1 years in NS and 4.9 ± 2.4 years in GHD. Mean height SDS increased from -2.79 SDS to -1.94 SDS in NS (P = 0.007) and from -3.43 SDS to -1.82 SDS in GHD (P ˂ 0.0001). Growth velocity increased from 3.7 ± 1.2 cm/yr to 8.5 ± 2.5 cm/yr (P ˂ 0.0001) and 6.5 ± 2.9 cm/yr (P = 0.016) during the first and second years of GH treatment, respectively, in NS and from 3.4 ± 1.5 cm/yr to 8.8 ± 2.3 cm/yr (P ˂ 0.0001) and 8.1 ± 3.2 cm/yr (P ˂ 0.0001) in GHD. No severe adverse effects were observed during treatment. Conclusion: GH treatment in the NS patients increased growth velocity significantly, especially during the 1 st year of treatment. GH treatment in NS is thought to be effective and relatively safe. (J Korean Soc Pediatr Endocrinol 2011;16:100-105)","PeriodicalId":346664,"journal":{"name":"Journal of Korean Society of Pediatric Endocrinology","volume":"532 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117040873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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