A. Solovev, V. E. Sinitsyn, Maria V. Sokolova, N. Kudryavtsev, A. Vladzymyrskyy, D. Semenov
BACKGROUND: The state of health of the pulmonary system and its impact on the overall well-being of the individual is an important aspect of modern medicine. Despite continuous progress in diagnostics and technology, epidemiologic data on pulmonary trunk health at the population level in Russia remain understudied. In the context of this problem, the present study is an in-depth population-based analysis of the status of pulmonary trunk dilatation using modern technology and artificial intelligence [1]. Pulmonary trunk dilatation (≥29 mm) may be associated with various pathologies including arterial hypertension, chronic obstructive pulmonary disease, heart failure, and other diseases of the circulatory system [2]. AIM: The aim of the study was to assess the prevalence of pulmonary trunk dilatation in the Moscow population using artificial intelligence technologies. MATERIALS AND METHODS: The study was conducted between September 2022 and February 2023 in the population of Moscow. A large amount of chest CT data was analyzed, including information on 134,218 patients (61,514 men and 72,704 women). Artificial intelligence technologies were used to automatically process this data. RESULTS: The results show that 49,227 (36.7%) patients — 23,720 (38.6%) men and 25,507 (35.1%) women — had evidence of pulmonary trunk dilatation. The analysis shows gender and age differences in the incidence of the pathology. The distribution of pulmonary trunk dilatation in the population shows age dependence. The percentage of patients with signs of pulmonary trunk dilatation increases with age: from 18.1% in the group of young people to 62.2% in the group of elderly people. CONCLUSIONS: The study provides the first epidemiological data on pulmonary trunk dilatation in Moscow and emphasizes the importance of further research in this area. The findings may serve as a basis for the development of effective diagnostic and treatment strategies, as well as for further research in the field of artificial intelligence in medicine.
{"title":"Epidemiological analysis of pulmonary artery dilation prevalence in Moscow: automated computed tomography image analysis","authors":"A. Solovev, V. E. Sinitsyn, Maria V. Sokolova, N. Kudryavtsev, A. Vladzymyrskyy, D. Semenov","doi":"10.17816/dd627074","DOIUrl":"https://doi.org/10.17816/dd627074","url":null,"abstract":"BACKGROUND: The state of health of the pulmonary system and its impact on the overall well-being of the individual is an important aspect of modern medicine. Despite continuous progress in diagnostics and technology, epidemiologic data on pulmonary trunk health at the population level in Russia remain understudied. In the context of this problem, the present study is an in-depth population-based analysis of the status of pulmonary trunk dilatation using modern technology and artificial intelligence [1]. \u0000Pulmonary trunk dilatation (≥29 mm) may be associated with various pathologies including arterial hypertension, chronic obstructive pulmonary disease, heart failure, and other diseases of the circulatory system [2]. \u0000AIM: The aim of the study was to assess the prevalence of pulmonary trunk dilatation in the Moscow population using artificial intelligence technologies. \u0000MATERIALS AND METHODS: The study was conducted between September 2022 and February 2023 in the population of Moscow. A large amount of chest CT data was analyzed, including information on 134,218 patients (61,514 men and 72,704 women). Artificial intelligence technologies were used to automatically process this data. \u0000RESULTS: The results show that 49,227 (36.7%) patients — 23,720 (38.6%) men and 25,507 (35.1%) women — had evidence of pulmonary trunk dilatation. The analysis shows gender and age differences in the incidence of the pathology. The distribution of pulmonary trunk dilatation in the population shows age dependence. The percentage of patients with signs of pulmonary trunk dilatation increases with age: from 18.1% in the group of young people to 62.2% in the group of elderly people. \u0000CONCLUSIONS: The study provides the first epidemiological data on pulmonary trunk dilatation in Moscow and emphasizes the importance of further research in this area. The findings may serve as a basis for the development of effective diagnostic and treatment strategies, as well as for further research in the field of artificial intelligence in medicine.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141681888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander A. Knysh, V. Sosnovtsev, I. Nabiev, P. Samokhvalov
BACKGROUND: The development of new scintillation materials based on fluorescent nanocrystals with a perovskite structure of CsPbBr3 composition and CdSe/ZnS quantum dots is a pressing topic that is being pursued by numerous scientific groups [1–4]. Both of these materials have a high potential for application in this role due to their excellent fluorophore properties, with a quantum yield of luminescence of approximately 100%. Additionally, they possess high values of the effective atomic Zeff number. The photoelectric cross section is dependent on Zeff as (Zeff)5, while the magnitude of X-ray absorption is dependent on Zeff as (Zeff)4/(AE3), where A is the atomic mass of the substance absorbing the γ-quantum and E is the energy of the X-ray photon [5]. AIM: The aim of the study was to develop a technique for fabricating scintillators based on quantum dots and polymer matrices with a high degree of transparency, high temporal stability of luminescence quantum yield, and short luminescence decay times (time of illumination or average lifetime of the substance in the excited state) for gamma-ray registration. MATERIALS AND METHODS: A HAMAMAMATSU R7400U-6 photomultiplier tube was employed to register scintillation signals. A 137Cs source with a γ-quantum energy of 661.7 keV was used as a source of ionizing radiation. RESULTS: At irradiation with γ-quanta of 137Cs isotope samples based on poly(para-methylstyrene) matrix cross-linked with divinylbenzene molecules (10% wt%), activated with naphthalene (10%, primary acceptor), anthracene (1%) and quantum dots/perovskite nanocrystals (0, 1–1.0%, re-emitter), the energy spectrum showed effective Compton scattering of gamma-quanta in matter on atoms included in quantum dots/perovskite nanocrystals. The study revealed that samples devoid of inorganic elements, including quantum dots and perovskite nanocrystals, do not exhibit the Compton effect for gamma-quanta. Furthermore, the paramethylstyrene matrix serves to safeguard perovskite nanocrystals from external influences. The photoluminescence quantum yield of bulk composite materials based on perovskite nanocrystals of the CsPbBr3 composition and poly(paramethylstyrene) remains constant over an extended period, with minimal fluctuations within the margin of error. CONCLUSIONS: Experimental evidence has demonstrated that quantum dots and perovskite nanocrystals encapsulated in various polymer matrices exhibit scintillator properties when subjected to ionizing radiation. The fabricated samples of perovskite nanocrystals/quantum dots and various polymers have been identified as the most promising candidates for use as scintillation material for the registration of X-ray and gamma radiation.
背景:许多科研小组都在开发基于 CsPbBr3 组成的包晶结构荧光纳米晶体和 CdSe/ZnS 量子点的新型闪烁材料 [1-4]。这两种材料都具有出色的荧光团特性,发光量子产率约为 100%,因此在这方面具有很大的应用潜力。此外,它们还具有较高的有效原子泽夫数。光电截面与 Zeff 的关系为 (Zeff)5,而 X 射线吸收的大小与 Zeff 的关系为 (Zeff)4/(AE3),其中 A 是吸收 γ 量子的物质的原子质量,E 是 X 射线光子的能量 [5]。目的:本研究旨在开发一种基于量子点和聚合物基质的闪烁体制造技术,这种闪烁体具有高透明度、高发光量子产率时间稳定性和短发光衰减时间(照射时间或物质在激发态的平均寿命),可用于伽马射线登记。材料与方法:使用 HAMAMATSU R7400U-6 光电倍增管来记录闪烁信号。使用γ-量子能量为 661.7 千伏的 137Cs 源作为电离辐射源。结果:137Cs 同位素样品基于与二乙烯基苯分子(10% wt%)交联的聚(对甲苯乙烯)基体,用萘(10%,主受体)、蒽(1%)和量子点/过氧化物纳米晶体(0,1-1.0%,再发射器)激活,能谱显示物质中的伽马量子对量子点/高闪石纳米晶体中的原子产生了有效的康普顿散射。研究表明,不含无机元素的样品,包括量子点和透辉石纳米晶体,对伽马量子不表现出康普顿效应。此外,对甲基苯乙烯基质还能保护殒石纳米晶体不受外界影响。基于 CsPbBr3 组成的闪长岩纳米晶体和聚(对甲基苯乙烯)的块状复合材料的光致发光量子产率在较长时间内保持稳定,误差范围内的波动极小。结论:实验证明,封装在各种聚合物基质中的量子点和包闪石纳米晶体在电离辐射下具有闪烁特性。制作的闪烁体纳米晶体/量子点样品和各种聚合物已被确定为最有希望用作闪烁材料的候选材料,可用于登记 X 射线和伽马射线辐射。
{"title":"Composite materials based on quantum dots and polymer matrices for gamma radiation registration in the next-generation scintillation detectors","authors":"Alexander A. Knysh, V. Sosnovtsev, I. Nabiev, P. Samokhvalov","doi":"10.17816/dd627009","DOIUrl":"https://doi.org/10.17816/dd627009","url":null,"abstract":"BACKGROUND: The development of new scintillation materials based on fluorescent nanocrystals with a perovskite structure of CsPbBr3 composition and CdSe/ZnS quantum dots is a pressing topic that is being pursued by numerous scientific groups [1–4]. Both of these materials have a high potential for application in this role due to their excellent fluorophore properties, with a quantum yield of luminescence of approximately 100%. Additionally, they possess high values of the effective atomic Zeff number. The photoelectric cross section is dependent on Zeff as (Zeff)5, while the magnitude of X-ray absorption is dependent on Zeff as (Zeff)4/(AE3), where A is the atomic mass of the substance absorbing the γ-quantum and E is the energy of the X-ray photon [5]. \u0000AIM: The aim of the study was to develop a technique for fabricating scintillators based on quantum dots and polymer matrices with a high degree of transparency, high temporal stability of luminescence quantum yield, and short luminescence decay times (time of illumination or average lifetime of the substance in the excited state) for gamma-ray registration. \u0000MATERIALS AND METHODS: A HAMAMAMATSU R7400U-6 photomultiplier tube was employed to register scintillation signals. A 137Cs source with a γ-quantum energy of 661.7 keV was used as a source of ionizing radiation. \u0000RESULTS: At irradiation with γ-quanta of 137Cs isotope samples based on poly(para-methylstyrene) matrix cross-linked with divinylbenzene molecules (10% wt%), activated with naphthalene (10%, primary acceptor), anthracene (1%) and quantum dots/perovskite nanocrystals (0, 1–1.0%, re-emitter), the energy spectrum showed effective Compton scattering of gamma-quanta in matter on atoms included in quantum dots/perovskite nanocrystals. \u0000The study revealed that samples devoid of inorganic elements, including quantum dots and perovskite nanocrystals, do not exhibit the Compton effect for gamma-quanta. Furthermore, the paramethylstyrene matrix serves to safeguard perovskite nanocrystals from external influences. The photoluminescence quantum yield of bulk composite materials based on perovskite nanocrystals of the CsPbBr3 composition and poly(paramethylstyrene) remains constant over an extended period, with minimal fluctuations within the margin of error. \u0000CONCLUSIONS: Experimental evidence has demonstrated that quantum dots and perovskite nanocrystals encapsulated in various polymer matrices exhibit scintillator properties when subjected to ionizing radiation. The fabricated samples of perovskite nanocrystals/quantum dots and various polymers have been identified as the most promising candidates for use as scintillation material for the registration of X-ray and gamma radiation.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141682157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. E. Panteleev, Kirill V. Maksimov, Alexey E. Shklyaev
BACKGROUND: One of the primary pathophysiological mechanisms of functional dyspepsia is a disruption in the postprandial reflex relaxation of the proximal part of the stomach, which results in an impairment of its motor-evacuation function. This impairment can be verified by magnetic resonance imaging with a stress drinking test. Correction of gastric relaxation accommodation disorders in functional dyspepsia is possible with the help of drinking mineral waters. However, further studies are required to assess the effect of these waters on the motor-evacuation function of the stomach. AIM: The study was aimed at comparative evaluation of the effect of intake of therapeutic medium mineralized sulfate-sodium-calcium mineral water and ordinary drinking water on gastric evacuation function using magnetic resonance tomography. MATERIALS AND METHODS: A two-fold magnetic resonance imaging procedure was conducted on an empty stomach using a closed-type Philips Intera 1.5T device (Philips, Netherlands) in 10 patients aged 22.8±1.2 years with a diagnosis of functional dyspepsia. On day 1, 200 ml of drinking water was used, and on day 2, 200 ml of mineral water was used. The examination was conducted in abdominal mode, with the subjects lying on their back. A slice thickness of 3 mm was used in coronal, axial, and sagittal projections, with images acquired every 5 minutes for 20 minutes. The following imaging modes were employed: T1, T2-weighted images, T2 Spair, and b-FFE. The volume of gastric contents and the rate of fluid evacuation were calculated using the RadiAnt DICOM Viewer program (Medixant, Poland). RESULTS: In patients with functional dyspepsia, the volume of liquid in the stomach after ingestion of 200 ml of drinking water was 163.71 ± 28.9 mL, while after ingestion of mineral water, the volume was 101.57 ± 26.88 mL. Furthermore, the volume of evacuated liquid after ingestion of mineral water was 1.040–2.5 times greater. By minute 15, the volume of liquid in the stomach was 8.0 ± 6.16 mL after mineral water intake and 58.85 ± 40.06 mL after drinking water. The mean gastric evacuation rate following ingestion of ordinary drinking water was 12.9 ± 5.29 mL/min, while that following ingestion of mineral water was 24.1 ± 4.53 mL/min (1.07–3.76 times greater). The increase in gastric evacuation rate observed in the examined subjects when using mineral water ranged from 7.58% to 276.21%. CONCLUSIONS: Magnetic resonance imaging of the stomach allows for the verification of the effect of mineral water on its motor-evacuation function, thus enabling the estimation of the rate of gastric emptying. A single intake of the studied mineral water has a prokinetic effect, which can be used to correct motor disorders in patients with functional dyspepsia.
{"title":"Magnetic resonance imaging as a method for evaluating the effect of drinking mineral water on motor-evacuation function","authors":"K. E. Panteleev, Kirill V. Maksimov, Alexey E. Shklyaev","doi":"10.17816/dd626507","DOIUrl":"https://doi.org/10.17816/dd626507","url":null,"abstract":"BACKGROUND: One of the primary pathophysiological mechanisms of functional dyspepsia is a disruption in the postprandial reflex relaxation of the proximal part of the stomach, which results in an impairment of its motor-evacuation function. This impairment can be verified by magnetic resonance imaging with a stress drinking test. Correction of gastric relaxation accommodation disorders in functional dyspepsia is possible with the help of drinking mineral waters. However, further studies are required to assess the effect of these waters on the motor-evacuation function of the stomach. \u0000AIM: The study was aimed at comparative evaluation of the effect of intake of therapeutic medium mineralized sulfate-sodium-calcium mineral water and ordinary drinking water on gastric evacuation function using magnetic resonance tomography. \u0000MATERIALS AND METHODS: A two-fold magnetic resonance imaging procedure was conducted on an empty stomach using a closed-type Philips Intera 1.5T device (Philips, Netherlands) in 10 patients aged 22.8±1.2 years with a diagnosis of functional dyspepsia. On day 1, 200 ml of drinking water was used, and on day 2, 200 ml of mineral water was used. The examination was conducted in abdominal mode, with the subjects lying on their back. A slice thickness of 3 mm was used in coronal, axial, and sagittal projections, with images acquired every 5 minutes for 20 minutes. The following imaging modes were employed: T1, T2-weighted images, T2 Spair, and b-FFE. The volume of gastric contents and the rate of fluid evacuation were calculated using the RadiAnt DICOM Viewer program (Medixant, Poland). \u0000RESULTS: In patients with functional dyspepsia, the volume of liquid in the stomach after ingestion of 200 ml of drinking water was 163.71 ± 28.9 mL, while after ingestion of mineral water, the volume was 101.57 ± 26.88 mL. Furthermore, the volume of evacuated liquid after ingestion of mineral water was 1.040–2.5 times greater. By minute 15, the volume of liquid in the stomach was 8.0 ± 6.16 mL after mineral water intake and 58.85 ± 40.06 mL after drinking water. The mean gastric evacuation rate following ingestion of ordinary drinking water was 12.9 ± 5.29 mL/min, while that following ingestion of mineral water was 24.1 ± 4.53 mL/min (1.07–3.76 times greater). The increase in gastric evacuation rate observed in the examined subjects when using mineral water ranged from 7.58% to 276.21%. \u0000CONCLUSIONS: Magnetic resonance imaging of the stomach allows for the verification of the effect of mineral water on its motor-evacuation function, thus enabling the estimation of the rate of gastric emptying. A single intake of the studied mineral water has a prokinetic effect, which can be used to correct motor disorders in patients with functional dyspepsia.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Voronkova, M. Ublinskiy, Anna A. Kobzeva, I. Melnikov
BACKGROUND: Ferroptosis plays a pivotal role in the pathophysiology of secondary disorders following brain injury. Disturbances in iron homeostasis result in the accumulation of iron and the formation of reactive oxygen species, which may contribute to the development of various neurodegenerative diseases. Magnetic susceptibility mapping is a novel, rapidly evolving quantitative technique with significant potential for assessing iron accumulation in the brain. AIM: The study aimed to determine changes in brain iron concentrations in patients with brain injury using magnetic susceptibility mapping techniques. MATERIALS AND METHODS: The study included 9 patients (14±2 years) with moderate and severe brain injury: three in the acute phase and six in the remote phase, and 4 healthy volunteers (15.3±0.9 years). All study participants underwent magnetic resonance imaging on a Philips Achieva dStream 3T scanner (Philips, the Netherlands). Data for magnetic susceptibility maps were acquired using a 3D FFE multi-echo sequence with flux compensation: FA=20, 6 TE: TE1/dTE=4.422 ms/5.795 ms, TR=59 ms (minimum), matrix size was 400×400×75, voxel size was 0.6×0.6×0.6 mm3. Magnetic susceptibility maps were generated using the SEPIA program. Magnetic field map construction, local magnetic field extraction, and magnetic susceptibility calculation were performed using the Laplacian, LBV, and iLSQR techniques, respectively. Average magnetic susceptibility values were obtained in 16 subcortical gray matter zones using the CIT168 atlas. RESULTS: The preliminary results of the study indicated that the patient group exhibited higher magnetic susceptibility values (p=0.07) in the compact part of the substantia nigra compared to the control group. The values for the patient and control groups were 0.03±0.03 and 0.003±0.018, respectively (Fig. 1). This result suggests a potential difference between the two groups at the level of a statistical trend, which may indicate iron accumulation in this area following brain injury. No changes in the values of magnetic susceptibility were observed in other areas of the subcortical gray matter that were investigated. An increased iron concentration in the compact part of the substantia nigra is also a characteristic of Parkinson’s disease [3]. This is consistent with the fact that brain injury is a risk factor for the development of this neurodegenerative disease. One of the possible causes of iron accumulation is neuronal death and increased permeability of the blood-brain barrier [4]. CONCLUSIONS: An elevated magnetic susceptibility value in the compact part of the substantia nigra in patients with brain injury may indicate the accumulation of iron in this area following injury. A larger sample size will allow for further testing of this hypothesis and the monitoring of changes in iron concentration over time following brain injury.
{"title":"Quantitative assessment of iron as a marker of neurodegeneration after traumatic brain injury","authors":"Elena Voronkova, M. Ublinskiy, Anna A. Kobzeva, I. Melnikov","doi":"10.17816/dd626180","DOIUrl":"https://doi.org/10.17816/dd626180","url":null,"abstract":"BACKGROUND: Ferroptosis plays a pivotal role in the pathophysiology of secondary disorders following brain injury. Disturbances in iron homeostasis result in the accumulation of iron and the formation of reactive oxygen species, which may contribute to the development of various neurodegenerative diseases. Magnetic susceptibility mapping is a novel, rapidly evolving quantitative technique with significant potential for assessing iron accumulation in the brain. \u0000AIM: The study aimed to determine changes in brain iron concentrations in patients with brain injury using magnetic susceptibility mapping techniques. \u0000MATERIALS AND METHODS: The study included 9 patients (14±2 years) with moderate and severe brain injury: three in the acute phase and six in the remote phase, and 4 healthy volunteers (15.3±0.9 years). All study participants underwent magnetic resonance imaging on a Philips Achieva dStream 3T scanner (Philips, the Netherlands). Data for magnetic susceptibility maps were acquired using a 3D FFE multi-echo sequence with flux compensation: FA=20, 6 TE: TE1/dTE=4.422 ms/5.795 ms, TR=59 ms (minimum), matrix size was 400×400×75, voxel size was 0.6×0.6×0.6 mm3. Magnetic susceptibility maps were generated using the SEPIA program. Magnetic field map construction, local magnetic field extraction, and magnetic susceptibility calculation were performed using the Laplacian, LBV, and iLSQR techniques, respectively. Average magnetic susceptibility values were obtained in 16 subcortical gray matter zones using the CIT168 atlas. \u0000RESULTS: The preliminary results of the study indicated that the patient group exhibited higher magnetic susceptibility values (p=0.07) in the compact part of the substantia nigra compared to the control group. The values for the patient and control groups were 0.03±0.03 and 0.003±0.018, respectively (Fig. 1). This result suggests a potential difference between the two groups at the level of a statistical trend, which may indicate iron accumulation in this area following brain injury. No changes in the values of magnetic susceptibility were observed in other areas of the subcortical gray matter that were investigated. \u0000An increased iron concentration in the compact part of the substantia nigra is also a characteristic of Parkinson’s disease [3]. This is consistent with the fact that brain injury is a risk factor for the development of this neurodegenerative disease. One of the possible causes of iron accumulation is neuronal death and increased permeability of the blood-brain barrier [4]. \u0000CONCLUSIONS: An elevated magnetic susceptibility value in the compact part of the substantia nigra in patients with brain injury may indicate the accumulation of iron in this area following injury. A larger sample size will allow for further testing of this hypothesis and the monitoring of changes in iron concentration over time following brain injury.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUND AND AIM: Multiple biliary hamartomas are a benign incidental finding in the hepatic context. Recognizing them is not easy if one has never seen them and does not have access to the right imagery. The aim of the study is to expand the radiologist's digital image library, enabling a quick and precise differential diagnosis. Indeed, multiple biliary hamartomas can be challenging to differentiate from other liver lesions based on imaging alone. This case highlights the importance of thorough radiological assessment and the need for a multidisciplinary approach, involving radiologists, hepatologists, and pathologists, to ensure a precise diagnosis. METHODS: The patient in the study presented at the hospital for a CT scan and after an abdominal MRI recommended by his general practitioner to assess the biliary tree (Magnetic Resonance Cholangiopancreatography, MRCP) due to persistent abdominal pain. They had never undergone an abdominal MRI before in their life. The discovery of hepatic lesions was incidental and unexpected RESULTS: The MRI investigation revealed multiple benign lesions in both hepatic lobes compatible with the von Meyenburg complex. These lesions are multiple hamartomas and behave differently in all MRI sequences. CONCLUSIONS: The images acquired with the different MRI sequences were carefully examined. Despite being multiple and scattered throughout the liver, the lesions appeared immediately benign and consistent with the incidental diagnosis of multiple biliary hamartomas. Medical practitioners should be aware of the existence of multiple biliary hamartomas and consider them in the differential diagnosis when patients present with hepatic abnormalities. This knowledge can prevent unnecessary interventions and guide appropriate patient management.
{"title":"Multiple biliary micro-hamartomas diagnosed in an unsuspecting elderly patient","authors":"Marina Balbino, Manuela Montatore, Giacomo Fascia, Ruggiero Tupputi, Federica Masino, Gianmichele Muscatella, Domenico Mannatrizio, Giuseppe Guglielmi","doi":"10.17816/dd623322","DOIUrl":"https://doi.org/10.17816/dd623322","url":null,"abstract":"BACKGROUND AND AIM: Multiple biliary hamartomas are a benign incidental finding in the hepatic context. Recognizing them is not easy if one has never seen them and does not have access to the right imagery. The aim of the study is to expand the radiologist's digital image library, enabling a quick and precise differential diagnosis. Indeed, multiple biliary hamartomas can be challenging to differentiate from other liver lesions based on imaging alone. This case highlights the importance of thorough radiological assessment and the need for a multidisciplinary approach, involving radiologists, hepatologists, and pathologists, to ensure a precise diagnosis. \u0000METHODS: The patient in the study presented at the hospital for a CT scan and after an abdominal MRI recommended by his general practitioner to assess the biliary tree (Magnetic Resonance Cholangiopancreatography, MRCP) due to persistent abdominal pain. They had never undergone an abdominal MRI before in their life. The discovery of hepatic lesions was incidental and unexpected \u0000RESULTS: The MRI investigation revealed multiple benign lesions in both hepatic lobes compatible with the von Meyenburg complex. These lesions are multiple hamartomas and behave differently in all MRI sequences. \u0000CONCLUSIONS: The images acquired with the different MRI sequences were carefully examined. Despite being multiple and scattered throughout the liver, the lesions appeared immediately benign and consistent with the incidental diagnosis of multiple biliary hamartomas. Medical practitioners should be aware of the existence of multiple biliary hamartomas and consider them in the differential diagnosis when patients present with hepatic abnormalities. This knowledge can prevent unnecessary interventions and guide appropriate patient management.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandr Chuprov, Irina Pavlovna Bolodurina, A. O. Lositskiy, A. Zhigalov
Background: Despite the mention in the provision of medical care for diseases of the organ of vision, adnexa and orbit about equipping the medical consultative and diagnostic department of the clinic with an optical coherence tomograph, dynamic monitoring of patients with retinal pathology after the start of treatment is most often carried out in a medical ophthalmological center, which reduces accessibility for patients with primary (first identified) morbidity requiring initiation of treatment. The required technology needs to be changed, intensified, incl. using artificial intelligence technologies. Aim: development of methodological foundations for organizational technology for dispensary observation of patients with pathology of the posterior segment of the eye using clinical decision support system (CDSS) based on artificial intelligence. Materials and methods: The assessment of the existing regulatory framework was carried out on the basis of an analysis of the Constitution of the Russian Federation, Federal laws, by-laws, and judicial practice. The creation of a methodology for a structured medical document describing an optical coherence tomography image was carried out using an expert method: a survey of 100 ophthalmologists with the appropriate level of education, incl. additional professional, engaged in the provision of medical services - specialized medical care (treatment) to patients with pathology of the posterior segment of the eye. Results: Using an expert method, 123 binary signs were selected and described to describe the structure of the macular region of the retina in normal and pathological conditions, of which 26 signs were identified that can be interpreted as predictors of worsening of the clinical course of the disease. Conclusion: The developed classifier made it possible to create and train a medical decision support system based on 60,000 medical images, which, as an information service, without making a diagnosis, can change the organization of the dynamic observation process: the formation of patient routing - a primary service using the developed CDSS; if there are signs of deterioration in the clinical picture - routing to a medical ophthalmological center to assess the dynamics, provide specialized services, incl. high-tech medical care.
{"title":"ORGANIZATION OF DISPENSARY OBSERVATION OF PATIENTS WITH PATHOLOGY OF THE MACULAR RETINA USING ARTIFICIAL INTELLIGENCE SYSTEMS","authors":"Aleksandr Chuprov, Irina Pavlovna Bolodurina, A. O. Lositskiy, A. Zhigalov","doi":"10.17816/dd623956","DOIUrl":"https://doi.org/10.17816/dd623956","url":null,"abstract":"Background: Despite the mention in the provision of medical care for diseases of the organ of vision, adnexa and orbit about equipping the medical consultative and diagnostic department of the clinic with an optical coherence tomograph, dynamic monitoring of patients with retinal pathology after the start of treatment is most often carried out in a medical ophthalmological center, which reduces accessibility for patients with primary (first identified) morbidity requiring initiation of treatment. The required technology needs to be changed, intensified, incl. using artificial intelligence technologies. \u0000Aim: development of methodological foundations for organizational technology for dispensary observation of patients with pathology of the posterior segment of the eye using clinical decision support system (CDSS) based on artificial intelligence. \u0000Materials and methods: The assessment of the existing regulatory framework was carried out on the basis of an analysis of the Constitution of the Russian Federation, Federal laws, by-laws, and judicial practice. The creation of a methodology for a structured medical document describing an optical coherence tomography image was carried out using an expert method: a survey of 100 ophthalmologists with the appropriate level of education, incl. additional professional, engaged in the provision of medical services - specialized medical care (treatment) to patients with pathology of the posterior segment of the eye. \u0000Results: Using an expert method, 123 binary signs were selected and described to describe the structure of the macular region of the retina in normal and pathological conditions, of which 26 signs were identified that can be interpreted as predictors of worsening of the clinical course of the disease. \u0000Conclusion: The developed classifier made it possible to create and train a medical decision support system based on 60,000 medical images, which, as an information service, without making a diagnosis, can change the organization of the dynamic observation process: the formation of patient routing - a primary service using the developed CDSS; if there are signs of deterioration in the clinical picture - routing to a medical ophthalmological center to assess the dynamics, provide specialized services, incl. high-tech medical care.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Y. Ussov, Aleksander Vladimirovich Friedmann, T. A. Bergen, A. R. Tarkova, A. M. Chernyavskiy, Irina Yur'evna Zhuravleva
A clinical case is presented and discussed when a patient with an instrumentally detected ascending aortic aneurysm with an expansion of the lumen up to 60 mm, after performing surgically flawless prosthetics, there was a marked decrease in exercise tolerance, a decrease in the contractile function of the left ventricular myocardium at rest, and an expansion of the pulmonary artery. It is shown that the leading factor was a decrease in the volume of systolic expansion of the aorta down to 5 ml, at the initial 13 ml, despite a noticeable increase in extensibility and a decrease in mechanical stiffness compared with initial indexes of the affected aortic wall. In this connection, the problems of creating aortic prostheses equivalent in terms of mechanical extensibility and elasticity to those for healthy biological tissues are discussed.
{"title":"Prospective evaluation of the extensibility of the ascending aorta wall and its vascular prosthesis in a patient with an aneurysm with technically flawless surgical correction and postoperative decrease in functional parameters. Clinical case and literature review.","authors":"W. Y. Ussov, Aleksander Vladimirovich Friedmann, T. A. Bergen, A. R. Tarkova, A. M. Chernyavskiy, Irina Yur'evna Zhuravleva","doi":"10.17816/dd568070","DOIUrl":"https://doi.org/10.17816/dd568070","url":null,"abstract":"A clinical case is presented and discussed when a patient with an instrumentally detected ascending aortic aneurysm with an expansion of the lumen up to 60 mm, after performing surgically flawless prosthetics, there was a marked decrease in exercise tolerance, a decrease in the contractile function of the left ventricular myocardium at rest, and an expansion of the pulmonary artery. It is shown that the leading factor was a decrease in the volume of systolic expansion of the aorta down to 5 ml, at the initial 13 ml, despite a noticeable increase in extensibility and a decrease in mechanical stiffness compared with initial indexes of the affected aortic wall. In this connection, the problems of creating aortic prostheses equivalent in terms of mechanical extensibility and elasticity to those for healthy biological tissues are discussed.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140248096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Александр Геннадьевич Арзамасцев, O. Fabrikantov, N. Zenkova, Sergey Belikov
Backgraund. Implantation of recent IOLs allows ophthalmologists to effectively solve the problems of surgical rehabilitation of patients with cataracts. The degree of improving the patient's visual functions is directly dependent on the accuracy of the preoperative calculation of the optical power of IOLs. The most famous formulas to calculate this indicator are SRK II, SRK/T, Hoffer-Q, Holladay II, Haigis, Barrett. All of them work well for an "average patient", however, they are not adequate enough at the boundaries of input variables ranges. Aims. To study the possibility of using mathematical models obtained as a result of deep learning of artificial neural networks (ANN models) to generalize data and predict the optical power of modern intraocular lenses. Materials and methods. ANN models were trained on large-scale samples, including depersonalized data for patients of ophthalmology clinic. Data provided in 2021 by ophthalmologist K.K. Syrykh, and reflect the results of both preoperative and postoperative observation of patients. The source file used to build the ANN model includes 455 records - 26 columns of input factors and one column for the output factor - calculating IOL (diopters). To conveniently build ANN models, we used a simulator program, previously developed by the authors. Results. The resulting models, in contrast to the traditionally used formulas, reflect the regional specificity of patients to a much greater extent. They also make it possible to retrain and optimize the structure based on newly received data, which allows taking into account the non-stationarity of the object. A distinctive feature of such ANN models in comparison with the well-known formulas SRK II, SRK/T, Hoffer-Q, Holladay II, Haigis, Barrett, widely used in the surgical cataract treatment in ophthalmology, is their ability to take into account a significant number of recorded input quantities, which makes it possible to reduce the mean relative error in calculating the optical power of IOL from 10–12% to 3.5%. Conclusions. This work shows the fundamental possibility of generalizing a significant amount of empirical data on calculating the optical power of the IOL using training ANN models that have a significantly larger number of input variables than when using traditional formulas and methods. The results obtained allow, in principle, to build an intelligent expert system with a continuous flow of new data from a source and a step-by-step retraining of the ANN model.
后视镜通过植入最新的人工晶体,眼科医生可以有效解决白内障患者的手术康复问题。患者视觉功能的改善程度直接取决于人工晶体光学功率术前计算的准确性。计算这一指标最有名的公式是 SRK II、SRK/T、Hoffer-Q、Holladay II、Haigis、Barrett。所有这些公式对 "普通患者 "都很有效,但在输入变量范围的边界上,它们就不够充分了。目的研究使用人工神经网络深度学习(ANN 模型)获得的数学模型来归纳数据和预测现代眼内透镜光学功率的可能性。材料和方法。在大规模样本(包括眼科诊所患者的非人格化数据)上训练 ANN 模型。数据由眼科医生 K.K. Syrykh 于 2021 年提供,反映了患者术前和术后的观察结果。用于建立 ANN 模型的源文件包括 455 条记录--26 列输入因子和一列输出因子--计算人工晶体(度数)。为了方便建立 ANN 模型,我们使用了作者之前开发的模拟器程序。结果。与传统的公式相比,所建立的模型更能反映患者的地区特异性。它们还能根据新收到的数据重新训练和优化结构,从而考虑到对象的非稳定性。与在眼科白内障手术治疗中广泛使用的著名公式 SRK II、SRK/T、Hoffer-Q、Holladay II、Haigis、Barrett 相比,这种 ANN 模型的一个显著特点是能够考虑大量记录的输入量,从而将计算人工晶体光学功率的平均相对误差从 10-12% 降低到 3.5%。结论。这项工作表明,与使用传统公式和方法相比,使用输入变量数量更多的训练方差网络模型,从根本上可以归纳计算人工晶体光学功率的大量经验数据。所获得的结果原则上允许建立一个智能专家系统,通过源源不断地获得新数据,并逐步重新训练 ANN 模型。
{"title":"Machine learning technology for predicting intraocular lens power. Diagnostics data generalization","authors":"Александр Геннадьевич Арзамасцев, O. Fabrikantov, N. Zenkova, Sergey Belikov","doi":"10.17816/dd623995","DOIUrl":"https://doi.org/10.17816/dd623995","url":null,"abstract":"Backgraund. Implantation of recent IOLs allows ophthalmologists to effectively solve the problems of surgical rehabilitation of patients with cataracts. The degree of improving the patient's visual functions is directly dependent on the accuracy of the preoperative calculation of the optical power of IOLs. The most famous formulas to calculate this indicator are SRK II, SRK/T, Hoffer-Q, Holladay II, Haigis, Barrett. All of them work well for an \"average patient\", however, they are not adequate enough at the boundaries of input variables ranges. \u0000Aims. To study the possibility of using mathematical models obtained as a result of deep learning of artificial neural networks (ANN models) to generalize data and predict the optical power of modern intraocular lenses. \u0000Materials and methods. ANN models were trained on large-scale samples, including depersonalized data for patients of ophthalmology clinic. Data provided in 2021 by ophthalmologist K.K. Syrykh, and reflect the results of both preoperative and postoperative observation of patients. The source file used to build the ANN model includes 455 records - 26 columns of input factors and one column for the output factor - calculating IOL (diopters). To conveniently build ANN models, we used a simulator program, previously developed by the authors. \u0000Results. The resulting models, in contrast to the traditionally used formulas, reflect the regional specificity of patients to a much greater extent. They also make it possible to retrain and optimize the structure based on newly received data, which allows taking into account the non-stationarity of the object. A distinctive feature of such ANN models in comparison with the well-known formulas SRK II, SRK/T, Hoffer-Q, Holladay II, Haigis, Barrett, widely used in the surgical cataract treatment in ophthalmology, is their ability to take into account a significant number of recorded input quantities, which makes it possible to reduce the mean relative error in calculating the optical power of IOL from 10–12% to 3.5%. \u0000Conclusions. This work shows the fundamental possibility of generalizing a significant amount of empirical data on calculating the optical power of the IOL using training ANN models that have a significantly larger number of input variables than when using traditional formulas and methods. The results obtained allow, in principle, to build an intelligent expert system with a continuous flow of new data from a source and a step-by-step retraining of the ANN model.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140247017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valerii Vasilev, Svetlana Nikolaevna Kondrichina, Konstantin Borisovich Tsekhanovich
Background. In recent years, it is important to change the methods and programs of teaching many disciplines, including ultrasound diagnostics, with the inclusion of various virtual and simula-tion devices. The practical experience of using such technologies in the teaching process is rather short, therefore, there are few original works devoted to this topic in Russian and foreign literature.Aims. To determine the possibilities and algorithm of using virtual simulator of ultrasound re-search in the process of teaching the discipline of "ultrasound diagnostics" on the basis of the results of work with it. To evaluate the advantages and disadvantages of using simulator in comparison with traditional teaching methods.Material and methods. The results of using the virtual simulator "Vimedix 3.2" in the educa-tional process were analyzed. Simulations of transabdominal ultrasound examination of abdominal cavity organs, transthoracic echocardiography, triplex scanning of main vessels were performed on it. The study involved 26 residents in the specialty "ultrasound diagnostics", as well as 47 physicians who were trained at professional retraining courses.Results. The use of a virtual simulator at the initial stage in the training process can eliminate many of the problems that residents and trainees encounter in clinical sites. The use of a simulator in the testing process seems to be less favorable than a practical examination using ultrasound scanners and real patients.Conclusions. It is advisable to use the simulator at the initial stage to practice the research methodology. It is recommended to develop and use additional teaching materials and programs in training. The advantages of the virtual simulator are comfort of work at the initial stage of training, short time of its mastering, availability of an extensive database of pathological cases. The identified non-critical deficiencies require correction during further training in the clinic.
{"title":"Possibilities of using the virtual simulator \"Vimedix 3.2\" in the process of training in the specialty \"ultrasound and diagnostics\"","authors":"Valerii Vasilev, Svetlana Nikolaevna Kondrichina, Konstantin Borisovich Tsekhanovich","doi":"10.17816/dd586551","DOIUrl":"https://doi.org/10.17816/dd586551","url":null,"abstract":"Background. In recent years, it is important to change the methods and programs of teaching many disciplines, including ultrasound diagnostics, with the inclusion of various virtual and simula-tion devices. The practical experience of using such technologies in the teaching process is rather short, therefore, there are few original works devoted to this topic in Russian and foreign literature.Aims. To determine the possibilities and algorithm of using virtual simulator of ultrasound re-search in the process of teaching the discipline of \"ultrasound diagnostics\" on the basis of the results of work with it. To evaluate the advantages and disadvantages of using simulator in comparison with traditional teaching methods.Material and methods. The results of using the virtual simulator \"Vimedix 3.2\" in the educa-tional process were analyzed. Simulations of transabdominal ultrasound examination of abdominal cavity organs, transthoracic echocardiography, triplex scanning of main vessels were performed on it. The study involved 26 residents in the specialty \"ultrasound diagnostics\", as well as 47 physicians who were trained at professional retraining courses.Results. The use of a virtual simulator at the initial stage in the training process can eliminate many of the problems that residents and trainees encounter in clinical sites. The use of a simulator in the testing process seems to be less favorable than a practical examination using ultrasound scanners and real patients.Conclusions. It is advisable to use the simulator at the initial stage to practice the research methodology. It is recommended to develop and use additional teaching materials and programs in training. The advantages of the virtual simulator are comfort of work at the initial stage of training, short time of its mastering, availability of an extensive database of pathological cases. The identified non-critical deficiencies require correction during further training in the clinic.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140251627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Solovev, Y. Vasilev, V. Sinitsyn, A. Petraikin, A. Vladzymyrskyy, I. Shulkin, D. Sharova, Dmitry S Semenov
Просьба см. прикреплённый файл с рукописью
请参见所附手稿文件
{"title":"Improving aortic aneurysm detection with artificial intelligence based on Chest CT data","authors":"A. Solovev, Y. Vasilev, V. Sinitsyn, A. Petraikin, A. Vladzymyrskyy, I. Shulkin, D. Sharova, Dmitry S Semenov","doi":"10.17816/dd569388","DOIUrl":"https://doi.org/10.17816/dd569388","url":null,"abstract":"Просьба см. прикреплённый файл с рукописью","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140253562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}