S. N. Gusev, Velichko Ln, Bogdanov Av, Khramenko Ni, Konovalova Nv, Kovtun Av
The coming era of COVID-19 introduces critical challenges for researchers. Accordingly, new questions connected with the current state of people’s health arise, namely, what consequences will be for the patients who have suffered from long COVID-19; what diseases are supposed to threaten the patients in the future; what immunity responses will be after the influence of antigen SARS-CoV-2; to what extent the organism changes caused by SARS-CoV-2 contribute to or prevent from the development of long-term protective immunity; how effective COVID19 vaccine will be for these patients. In this connection, some of the above-mentioned items have been highlighted in this research work. The study was conducted in 49 patients with ophthalmic pathologies who had previously undergone COVID-19. It should be stressed that examination of eye disorders is very essential because they allow in a non-traumatic way to obtain lifetime visualization of the state of blood vessels and capillaries, as well as to assess the effect of the virus on the central nervous system. Moreover, immunological studies made it possible to draw a conclusion about the state of
{"title":"Mercureid Gives New Opportunities for Treatment and Prevention of Complications Caused by COVID-19 in Patients with Ophthalmic Pathologies","authors":"S. N. Gusev, Velichko Ln, Bogdanov Av, Khramenko Ni, Konovalova Nv, Kovtun Av","doi":"10.46889/joar.2021.2305","DOIUrl":"https://doi.org/10.46889/joar.2021.2305","url":null,"abstract":"The coming era of COVID-19 introduces critical challenges for researchers. Accordingly, new questions connected with the current state of people’s health arise, namely, what consequences will be for the patients who have suffered from long COVID-19; what diseases are supposed to threaten the patients in the future; what immunity responses will be after the influence of antigen SARS-CoV-2; to what extent the organism changes caused by SARS-CoV-2 contribute to or prevent from the development of long-term protective immunity; how effective COVID19 vaccine will be for these patients. In this connection, some of the above-mentioned items have been highlighted in this research work. The study was conducted in 49 patients with ophthalmic pathologies who had previously undergone COVID-19. It should be stressed that examination of eye disorders is very essential because they allow in a non-traumatic way to obtain lifetime visualization of the state of blood vessels and capillaries, as well as to assess the effect of the virus on the central nervous system. Moreover, immunological studies made it possible to draw a conclusion about the state of","PeriodicalId":348405,"journal":{"name":"Journal of Ophthalmology and Advance Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131240055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael O'Sullivan, A. Catanzaro, Kyle Swerhun, Sanjoy Gupta
The objective of this investigation was to present a case of masquerade syndrome secondary to primary CNS lymphoma in a Northern Ontario community. Masquerade syndrome of primary CNS lymphoma in the eye can often be misinterpreted as an immune-mediated process, owing to its tendency to first present with only vitreous cell, or chronic uveitis. Correct diagnosis of intraocular primary CNS lymphoma requires clinical suspicion and ophthalmologists should have a low threshold for triggering a diagnostic work-up of older and immunocompromised patients with a characteristic presentation.
{"title":"Masquerade Syndrome: Diagnostic Challenges in a Case of Primary Central Nervous System Lymphoma","authors":"Michael O'Sullivan, A. Catanzaro, Kyle Swerhun, Sanjoy Gupta","doi":"10.46889/joar.2021.2304","DOIUrl":"https://doi.org/10.46889/joar.2021.2304","url":null,"abstract":"The objective of this investigation was to present a case of masquerade syndrome secondary to primary CNS lymphoma in a Northern Ontario community. Masquerade syndrome of primary CNS lymphoma in the eye can often be misinterpreted as an immune-mediated process, owing to its tendency to first present with only vitreous cell, or chronic uveitis. Correct diagnosis of intraocular primary CNS lymphoma requires clinical suspicion and ophthalmologists should have a low threshold for triggering a diagnostic work-up of older and immunocompromised patients with a characteristic presentation.","PeriodicalId":348405,"journal":{"name":"Journal of Ophthalmology and Advance Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121775135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To evaluate the outcome of immediate management in acute ocular chemical burns. Methods: 29 eyes of 19 patients with acute chemical burns were studied. All patients received immediate first aid. Limbal and conjunctival involvement were graded as per Dua's classification. 86.8% patients with grade 1, 2 and 3 were managed conservatively while amniotic membrane transplantation was performed in 13.7% of patients who had grade 4 or grade 5 involvement. All patients were followed up for a period of 6 months. Results: 73.6% patients presented with alkali burns while 26.3% patients presented with acid burns. 3.4% eyes had grade I involvement, 55.1% eyes had grade II, 27.5% eyes had grade III, 3.4% eyes had grade IV and 3.4% had grade V involvement. Of 29 eyes, 86% showed epithelialization by 8 weeks, and rest 13.7% showed complete epithelialization by 4 months. On long term follow-up, complications were seen in 13.6% eyes. Symblepharon occurred in 6.8% eyes and rest 6.8% eyes developed corneal vascularization due to secondary limbal stem cell deficiency. None of the eyes showed worsening signs of corneal thinning and perforation. Conclusions: Immediate intervention in acute ocular burns, in the form of medical or surgical, prevents further ocular surface damage, promotes wound healing, and hinders visually debilitating cicatricial sequelae. In our experience, surgical intervention in patients with Grade 4 involvement and above leads to early rehabilitation and gain of visual function.
{"title":"Outcome of Immediate Management in Chemical Ocular Burns","authors":"S. Thatte, G. Tiwari","doi":"10.46889/joar.2021.2301","DOIUrl":"https://doi.org/10.46889/joar.2021.2301","url":null,"abstract":"Purpose: To evaluate the outcome of immediate management in acute ocular chemical burns. Methods: 29 eyes of 19 patients with acute chemical burns were studied. All patients received immediate first aid. Limbal and conjunctival involvement were graded as per Dua's classification. 86.8% patients with grade 1, 2 and 3 were managed conservatively while amniotic membrane transplantation was performed in 13.7% of patients who had grade 4 or grade 5 involvement. All patients were followed up for a period of 6 months. Results: 73.6% patients presented with alkali burns while 26.3% patients presented with acid burns. 3.4% eyes had grade I involvement, 55.1% eyes had grade II, 27.5% eyes had grade III, 3.4% eyes had grade IV and 3.4% had grade V involvement. Of 29 eyes, 86% showed epithelialization by 8 weeks, and rest 13.7% showed complete epithelialization by 4 months. On long term follow-up, complications were seen in 13.6% eyes. Symblepharon occurred in 6.8% eyes and rest 6.8% eyes developed corneal vascularization due to secondary limbal stem cell deficiency. None of the eyes showed worsening signs of corneal thinning and perforation. Conclusions: Immediate intervention in acute ocular burns, in the form of medical or surgical, prevents further ocular surface damage, promotes wound healing, and hinders visually debilitating cicatricial sequelae. In our experience, surgical intervention in patients with Grade 4 involvement and above leads to early rehabilitation and gain of visual function.","PeriodicalId":348405,"journal":{"name":"Journal of Ophthalmology and Advance Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117122997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. J, Bærland Tp, Solberg El, Hermansen No, Andersen Ct, Eide N
Endophthalmitis caused by Phialemonium species are rare. We report a 68-year-old female with unilateral Phialemonium curvatum endophthalmitis. She presented with a two day history of right-sided floaters and reduced vision to finger counting, initially treated as iridocyclitis with topical and systemic steroids. Due to worsening, a diagnostic vitrectomy was performed. The culture from the vitreous cavity yielded Phialemonium curvatum growth. She was treated with amphotericin B intravitreally once and voriconazole tablets for three months with gain of Best Corrected Visual Acuity (BCVA) to 0.3. Six weeks following discontinuation of voriconazole, the patient developed right-sided eye pain and deterioration of the visual acuity. A second diagnostic vitrectomy was performed and once again the culture demonstrated growth of Phialemonium curvatum. She was treated with voriconazole for six months. Further, she developed eye pain and reduced vision in her right eye about 2 years following the second diagnostic vitrectomy. A third diagnostic vitrectomy was performed which was negative. Two weeks following the third diagnostic vitrectomy, the patient presented with retinal detachment and macular hole in the same eye. Retinal detachment persisted even following surgical repair with silicone insertion. The patient declined further surgeries. About ten years following initial presentation she developed intolerable right-sided eye pain and phthisis. The eye was eviscerated.
{"title":"A Case Report of Phialemonium Curvatum Endophthalmitis","authors":"N. J, Bærland Tp, Solberg El, Hermansen No, Andersen Ct, Eide N","doi":"10.46889/joar.2022.3104","DOIUrl":"https://doi.org/10.46889/joar.2022.3104","url":null,"abstract":"Endophthalmitis caused by Phialemonium species are rare. We report a 68-year-old female with unilateral Phialemonium curvatum endophthalmitis. She presented with a two day history of right-sided floaters and reduced vision to finger counting, initially treated as iridocyclitis with topical and systemic steroids. Due to worsening, a diagnostic vitrectomy was performed. The culture from the vitreous cavity yielded Phialemonium curvatum growth. She was treated with amphotericin B intravitreally once and voriconazole tablets for three months with gain of Best Corrected Visual Acuity (BCVA) to 0.3. Six weeks following discontinuation of voriconazole, the patient developed right-sided eye pain and deterioration of the visual acuity. A second diagnostic vitrectomy was performed and once again the culture demonstrated growth of Phialemonium curvatum. She was treated with voriconazole for six months. Further, she developed eye pain and reduced vision in her right eye about 2 years following the second diagnostic vitrectomy. A third diagnostic vitrectomy was performed which was negative. Two weeks following the third diagnostic vitrectomy, the patient presented with retinal detachment and macular hole in the same eye. Retinal detachment persisted even following surgical repair with silicone insertion. The patient declined further surgeries. About ten years following initial presentation she developed intolerable right-sided eye pain and phthisis. The eye was eviscerated.","PeriodicalId":348405,"journal":{"name":"Journal of Ophthalmology and Advance Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126855030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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