Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa4007
Nils Hoyer, Michael Brun Andersen, Lenne Collatz Laustrup, Saher Burhan Shaker
Introduction: Few studies describe whether the extent of radiologic fibrosis correlates with other measures of disease severity in patients with idiopathic pulmonary fibrosis (IPF). A direct correlation could confirm that the clinical and physiological limitations in these patients are attributed to the extent of fibrosis, rather than co-morbidities, such as emphysema, or subjective factors. Objectives: To assess the correlation between a visual fibrosis score and lung function, quality of life and symptoms. Methods: Patients with IPF were recruited from the Danish PFBIO cohort. The HRCT scans were scored by two experienced thoracic radiologists using a standardized form and blinded to patient data, each-others scores and the time of scan. The extents of reticulation, traction bronchiectasis and honeycombing were combined in a composite quantitative fibrosis score. Dyspnoea was assessed in a questionnaire on a scale from 0 to 5. Results: In the 66 included patients, fibrosis score was correlated with FVC (r=-0.35, p=0.005), DLCO (r=-0.53, p<0.001), St. George’s Respiratory Questionnaire (r=0.46, p=0.002) and dyspnoea (r=0.51, p<0.001). There was no significant difference between patients with or without concomitant emphysema. Conclusions: A visual fibrosis score in IPF correlates with lung function tests, quality of life and dyspnoea, further validating these measurements as directly related to the extent of lung fibrosis.
{"title":"HRCT composite fibrosis score correlates with clinical and physiological parameters in IPF","authors":"Nils Hoyer, Michael Brun Andersen, Lenne Collatz Laustrup, Saher Burhan Shaker","doi":"10.1183/13993003.congress-2023.pa4007","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa4007","url":null,"abstract":"<b>Introduction:</b> Few studies describe whether the extent of radiologic fibrosis correlates with other measures of disease severity in patients with idiopathic pulmonary fibrosis (IPF). A direct correlation could confirm that the clinical and physiological limitations in these patients are attributed to the extent of fibrosis, rather than co-morbidities, such as emphysema, or subjective factors. <b>Objectives:</b> To assess the correlation between a visual fibrosis score and lung function, quality of life and symptoms. <b>Methods:</b> Patients with IPF were recruited from the Danish PFBIO cohort. The HRCT scans were scored by two experienced thoracic radiologists using a standardized form and blinded to patient data, each-others scores and the time of scan. The extents of reticulation, traction bronchiectasis and honeycombing were combined in a composite quantitative fibrosis score. Dyspnoea was assessed in a questionnaire on a scale from 0 to 5. <b>Results:</b> In the 66 included patients, fibrosis score was correlated with FVC (r=-0.35, p=0.005), DLCO (r=-0.53, p<0.001), St. George’s Respiratory Questionnaire (r=0.46, p=0.002) and dyspnoea (r=0.51, p<0.001). There was no significant difference between patients with or without concomitant emphysema. <b>Conclusions:</b> A visual fibrosis score in IPF correlates with lung function tests, quality of life and dyspnoea, further validating these measurements as directly related to the extent of lung fibrosis.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3534
Dušan Ivković, Stevan Ivković, Aleksandar Ivković
Purpose: to explore medical management strategies for Covid-19 and future pandemic are designed to modify consumer and provider behavior to improve the quality and outcome of healthcare delivery. Method: we had 15874 patients with covid 19. All of them had at least CT examination, there were x-ray examinations, laboratory and MR for patients with different symptoms. A new and rapidly changing health care environment is forcing usage of more and more strategies. Results: To create competitive advantage, enterprise architecture and technology innovation leaders must evaluate top trends to identify opportunities that their organizations can exploit. These are strategies we use for managing private diagnostic center. Future trends for medical managements are AI foundation, Intelligent apps and analytics, intelligent things, Augmented Analytics Will Enable Users to Spend More Time Acting on Insights Digital twins, Cloud to the edge, Edge Computing Brings Distributed Computing Into the Cloud Style conversational platforms, Integration With Third-Party Services Will Further Increase Usefulness, Immersive Experience, Blockchain Offers Significant Potential Long-Term Benefits Despite Its Challenges, Event-Driven Model, Events Will Become More Important in the Intelligent Digital Mesh, Continuous Adaptive Risk and Trust, Barriers Must Come Down Between Security and Application Teams. The old way management is no useful. Implementing of this technique is vital for private hospitals. Our result is visualized in cost control, health improvement and positive consumer experiences. Conclusion: Any of these strategies have great value but together bring success in the management of epidemic.
{"title":"Medical managment strategies in epidemic","authors":"Dušan Ivković, Stevan Ivković, Aleksandar Ivković","doi":"10.1183/13993003.congress-2023.pa3534","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3534","url":null,"abstract":"<b>Purpose:</b> to explore medical management strategies for Covid-19 and future pandemic are designed to modify consumer and provider behavior to improve the quality and outcome of healthcare delivery. Method: we had 15874 patients with covid 19. All of them had at least CT examination, there were x-ray examinations, laboratory and MR for patients with different symptoms. A new and rapidly changing health care environment is forcing usage of more and more strategies. <b>Results:</b> To create competitive advantage, enterprise architecture and technology innovation leaders must evaluate top trends to identify opportunities that their organizations can exploit. These are strategies we use for managing private diagnostic center. Future trends for medical managements are AI foundation, Intelligent apps and analytics, intelligent things, Augmented Analytics Will Enable Users to Spend More Time Acting on Insights Digital twins, Cloud to the edge, Edge Computing Brings Distributed Computing Into the Cloud Style conversational platforms, Integration With Third-Party Services Will Further Increase Usefulness, Immersive Experience, Blockchain Offers Significant Potential Long-Term Benefits Despite Its Challenges, Event-Driven Model, Events Will Become More Important in the Intelligent Digital Mesh, Continuous Adaptive Risk and Trust, Barriers Must Come Down Between Security and Application Teams. The old way management is no useful. Implementing of this technique is vital for private hospitals. Our result is visualized in cost control, health improvement and positive consumer experiences. <b>Conclusion:</b> Any of these strategies have great value but together bring success in the management of epidemic.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3543
Jens Thomas Bakker, Jorine E. Hartman, Karin Klooster, David A. Lynch, Marieke C. Van Der Molen, Jean-Paul Charbonnier, Michail Tsiaousis, Rozemarijn Vliegenthart, Dirk-Jan Slebos
Introduction The relation between the degree of diaphragm flattening and lung function impairment in COPD remains largely unknown. We aim to develop a CT-based diaphragm analysis tool to investigate the association between diaphragm configuration and pulmonary function in COPD. Methods We developed a CT-based diaphragm analysis tool based on: 1) identification of the pulmonary lobes using an AI-based lung quantification platform (LungQ, Thirona, Nijmegen, The Netherlands), 2) extraction of a 3D-shape map of the lung-diaphragm intersection (Figure 1A), and 3) calculation of a diaphragm index (ratio of diaphragm surface area/projected surface area). Inspiratory CT scans from the first phase of the COPDGene study (n=9567) were used to evaluate the relation between the automatically extracted diaphragm index and FEV1 %-predicted, GOLD stages, and CT quantified emphysema (LAA<-950) (Figure 1). Results We found a significant association between the diaphragm index and emphysema (Figure 1C), FEV1 %- predicted (Figure 1D), and the COPD GOLD stages (Figure 1B). Conclusions With an in-house developed, automatic CT-based diaphragm analysis tool, we showed significant differences in diaphragm configuration relative to pulmonary function in COPD.
{"title":"Late Breaking Abstract - CT-based diaphragm analysis to evaluate the diaphragm configuration with increasing COPD severity","authors":"Jens Thomas Bakker, Jorine E. Hartman, Karin Klooster, David A. Lynch, Marieke C. Van Der Molen, Jean-Paul Charbonnier, Michail Tsiaousis, Rozemarijn Vliegenthart, Dirk-Jan Slebos","doi":"10.1183/13993003.congress-2023.pa3543","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3543","url":null,"abstract":"<b>Introduction</b> The relation between the degree of diaphragm flattening and lung function impairment in COPD remains largely unknown. We aim to develop a CT-based diaphragm analysis tool to investigate the association between diaphragm configuration and pulmonary function in COPD. <b>Methods</b> We developed a CT-based diaphragm analysis tool based on: 1) identification of the pulmonary lobes using an AI-based lung quantification platform (LungQ, Thirona, Nijmegen, The Netherlands), 2) extraction of a 3D-shape map of the lung-diaphragm intersection (Figure 1A), and 3) calculation of a diaphragm index (ratio of diaphragm surface area/projected surface area). Inspiratory CT scans from the first phase of the COPDGene study (n=9567) were used to evaluate the relation between the automatically extracted diaphragm index and FEV1 %-predicted, GOLD stages, and CT quantified emphysema (LAA<-950) (Figure 1). <b>Results</b> We found a significant association between the diaphragm index and emphysema (Figure 1C), FEV1 %- predicted (Figure 1D), and the COPD GOLD stages (Figure 1B). <b>Conclusions</b> With an in-house developed, automatic CT-based diaphragm analysis tool, we showed significant differences in diaphragm configuration relative to pulmonary function in COPD.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3527
Aleksandar Ivkovic, Tamara Milosavljevic, Ivana Svilarov, Stevan Ivkovic, Dusan Ivkovic
{"title":"CT findings as prediction of long covid","authors":"Aleksandar Ivkovic, Tamara Milosavljevic, Ivana Svilarov, Stevan Ivkovic, Dusan Ivkovic","doi":"10.1183/13993003.congress-2023.pa3527","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3527","url":null,"abstract":"","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136265383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa2286
Rodrigo Nava, François-Xavier Blé, Cosma Mirella Spalluto, Karl Staples, Tom Wilkinson, Kristoffer Ostridge
Introduction: Airway remodelling is a key feature in chronic respiratory diseases. Using CT imaging, shape analysis, and fractal dimension we aimed to investigate the structure and geometry of the tracheobronchial tree in COPD. Methods: Volumetric CT scans from 30 mild/moderate COPD subjects and 37 healthy controls were segmented. Experiments were divided into two categories: Compactness, eccentricity, and convexity were calculated at airway luminal level; whereas airway count along fractal-dimension rate, density, and airway length were used to quantify the tracheobronchial tree. More-routine CT airway measures such as Pi10 and wall area fraction were also extracted. XGBoost, a decision tree method, was used to score feature importance in predicting COPD. Results: There were significantly fewer airways in COPD subjects (233±88) compared to controls (359±89), with noticeable differences seen in all CT airway parameters (Fig. 1). Feature importance confirms that our novel descriptors strongly contribute to describing COPD and were more discriminant than the routine CT measures. Fig. 1 Mean and σ of CT airway measures. *Two categories were considered. Conclusion: We demonstrated significantly fewer airways and abnormal geometry and structure in our relatively mild COPD cohort. These new features have the potential to be a non-invasive biomarker of airway remodelling in COPD and potentially other respiratory disorders.
{"title":"Can tracheobronchial tree and luminal descriptors be used as objective imaging biomarkers in COPD?","authors":"Rodrigo Nava, François-Xavier Blé, Cosma Mirella Spalluto, Karl Staples, Tom Wilkinson, Kristoffer Ostridge","doi":"10.1183/13993003.congress-2023.pa2286","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2286","url":null,"abstract":"<b>Introduction:</b> Airway remodelling is a key feature in chronic respiratory diseases. Using CT imaging, shape analysis, and fractal dimension we aimed to investigate the structure and geometry of the tracheobronchial tree in COPD. <b>Methods:</b> Volumetric CT scans from 30 mild/moderate COPD subjects and 37 healthy controls were segmented. Experiments were divided into two categories: Compactness, eccentricity, and convexity were calculated at airway luminal level; whereas airway count along fractal-dimension rate, density, and airway length were used to quantify the tracheobronchial tree. More-routine CT airway measures such as Pi10 and wall area fraction were also extracted. XGBoost, a decision tree method, was used to score feature importance in predicting COPD. <b>Results:</b> There were significantly fewer airways in COPD subjects (233±88) compared to controls (359±89), with noticeable differences seen in all CT airway parameters (<i>Fig. 1</i>). Feature importance confirms that our novel descriptors strongly contribute to describing COPD and were more discriminant than the routine CT measures. <i>Fig. 1</i> Mean and σ of CT airway measures. *Two categories were considered. <b>Conclusion:</b> We demonstrated significantly fewer airways and abnormal geometry and structure in our relatively mild COPD cohort. These new features have the potential to be a non-invasive biomarker of airway remodelling in COPD and potentially other respiratory disorders.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136193309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa2284
Tjeerd van der Veer, Anastasia Kimberley Ay-Lan Kwee, Leticia Gallardo Estrella, Elrozy R. Andrinopoulou, Jean Paul Charbonnier, Stephen M. Humphries, Pim A. De Jong, David A. Lynch, Harm A. W. M. Tiddens, Esther Pompe
Aims: Emphysema in COPD can lead to loss of microscopic pulmonary arteries and secondary pulmonary hypertension. Aim: To determine the association between pulmonary artery volume on CT and mortality. Methods: The artery-vein phenotyping analysis (AVX) was performed using the AI-based lung quantification platform LungQ (Thirona, The Netherlands). AVX quantified total volume of small (diameter <2mm; AVXSA) and large (≥2mm; AVXLA) pulmonary arteries from inspiratory CT in 7903 participants in the COPDGene study, normalized for body height. Cox regression analysis was used to analyze associations between AVX scores and mortality. Corrections were made for age, sex, BMI, FEV1%predicted, mMRC, 6MWT, smoking status, emphysema, airway wall thickness, coronary artery calcium score, severe exacerbations, and scanner model. Results: Average age was 60.1±9.0 years, 3594 (45.5%) subjects had COPD. AVXSA was 103.3±21.5 mm3/cm and AVXLA was 201.9±68.1 mm3/cm. Higher AVXSA and AVXLA were both associated with higher mortality, HR 1.23 (CI 1.10-1.38) and HR 1.17 (CI 1.12-1.22) per 50 mm3/cm increase, respectively. Conclusions: An increased pulmonary arterial volume is associated with mortality, independent of emphysema. AVXSA and AVXLA may be markers of secondary blood flow redistribution and arterial dilatation due to destruction of more distal arterioles, potentially leading to pulmonary hypertension.
{"title":"CT-quantified pulmonary artery volume associates independently with higher mortality in smokers with and without COPD","authors":"Tjeerd van der Veer, Anastasia Kimberley Ay-Lan Kwee, Leticia Gallardo Estrella, Elrozy R. Andrinopoulou, Jean Paul Charbonnier, Stephen M. Humphries, Pim A. De Jong, David A. Lynch, Harm A. W. M. Tiddens, Esther Pompe","doi":"10.1183/13993003.congress-2023.pa2284","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2284","url":null,"abstract":"<b>Aims:</b> Emphysema in COPD can lead to loss of microscopic pulmonary arteries and secondary pulmonary hypertension. <b>Aim:</b> To determine the association between pulmonary artery volume on CT and mortality. <b>Methods:</b> The artery-vein phenotyping analysis (AVX) was performed using the AI-based lung quantification platform LungQ (Thirona, The Netherlands). AVX quantified total volume of small (diameter <2mm; AVX<sub>SA</sub>) and large (≥2mm; AVX<sub>LA</sub>) pulmonary arteries from inspiratory CT in 7903 participants in the COPDGene study, normalized for body height. Cox regression analysis was used to analyze associations between AVX scores and mortality. Corrections were made for age, sex, BMI, FEV1%predicted, mMRC, 6MWT, smoking status, emphysema, airway wall thickness, coronary artery calcium score, severe exacerbations, and scanner model. <b>Results:</b> Average age was 60.1±9.0 years, 3594 (45.5%) subjects had COPD. AVX<sub>SA</sub> was 103.3±21.5 mm3/cm and AVX<sub>LA</sub> was 201.9±68.1 mm3/cm. Higher AVX<sub>SA</sub> and AVX<sub>LA</sub> were both associated with higher mortality, HR 1.23 (CI 1.10-1.38) and HR 1.17 (CI 1.12-1.22) per 50 mm3/cm increase, respectively. <b>Conclusions:</b> An increased pulmonary arterial volume is associated with mortality, independent of emphysema. AVX<sub>SA</sub> and AVX<sub>LA</sub> may be markers of secondary blood flow redistribution and arterial dilatation due to destruction of more distal arterioles, potentially leading to pulmonary hypertension.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136193539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa2276
Maximilian Zubke, Marius Wernz, Till F Kaireit, Tawfik Moher Alsady, Andreas Voskrebenzev, Robin A Mueller, Karen M Olsson, Frank Wacker, Marius M Hoeper, Jens Vogel-Claussen
Introduction: Mean pulmonary arterial pressure (mPAP) is a biomarker of pulmonary hypertension (PHT), which is currently determined by right heart catheterization (RHC) as the clinical standard. Phase-resolved functional lung MRI (PREFUL) is a non-invasive imaging technique, which can calculate the pulse wave propagation in pulmonary vasculature during a virtual cardiac cycle of 15 phases. We hypothesize that deep learning tools may be able to estimate mPAP from dynamic pulse wave propagation images derived by PREFUL. Method: 92 (f=48, PHT=57) subjects underwent PREFUL and RHC. Per patient, pulse wave propagation images of coronal, central slice as well as the next ventral and dorsal location in the thorax were combined as input data. mPAP given by RHC was defined as target output data. Finally, a combination of three Denset-201 with one regression network was trained to realize the aforementioned mapping with 60 subjects, tested with 32 remaining cases. The correlation of the network’s final output with the mPAP from RHC was measured using Pearson’s Correlation. Results: For both training and holdout test data, final output of our method showed a significant correlation with RHC (p<0.05). Conclusions: Non-invasive measurement of mPAP using PREFUL-MRI and deep learning appears feasible and needs to be further explored.
{"title":"Deep learning enables non-invasive estimation of mean pulmonary arterial pressure from PREFUL-MRI","authors":"Maximilian Zubke, Marius Wernz, Till F Kaireit, Tawfik Moher Alsady, Andreas Voskrebenzev, Robin A Mueller, Karen M Olsson, Frank Wacker, Marius M Hoeper, Jens Vogel-Claussen","doi":"10.1183/13993003.congress-2023.pa2276","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2276","url":null,"abstract":"<b>Introduction:</b> Mean pulmonary arterial pressure (mPAP) is a biomarker of pulmonary hypertension (PHT), which is currently determined by right heart catheterization (RHC) as the clinical standard. Phase-resolved functional lung MRI (PREFUL) is a non-invasive imaging technique, which can calculate the pulse wave propagation in pulmonary vasculature during a virtual cardiac cycle of 15 phases. We hypothesize that deep learning tools may be able to estimate mPAP from dynamic pulse wave propagation images derived by PREFUL. <b>Method:</b> 92 (f=48, PHT=57) subjects underwent PREFUL and RHC. Per patient, pulse wave propagation images of coronal, central slice as well as the next ventral and dorsal location in the thorax were combined as input data. mPAP given by RHC was defined as target output data. Finally, a combination of three Denset-201 with one regression network was trained to realize the aforementioned mapping with 60 subjects, tested with 32 remaining cases. The correlation of the network’s final output with the mPAP from RHC was measured using Pearson’s Correlation. <b>Results:</b> For both training and holdout test data, final output of our method showed a significant correlation with RHC (p<0.05). <b>Conclusions:</b> Non-invasive measurement of mPAP using PREFUL-MRI and deep learning appears feasible and needs to be further explored.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136194411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.oa4855
Sofi Vassileva, Pieta C. Wijsman, Tatiana Soldati, Margherita Vaselli, Annika W.M. Goorsenberg, Daniel M. De Bruin, Johannes F. De Boer, Jouke T. Annema, Peter I. Bonta
Introduction: The gold standard to assess airway wall composition is by invasive focal biopsies. Endobronchial optical coherence tomography (EB-OCT) generates in vivo real-time high resolution images of the airways. Polarization sensitive OCT (EB-PS-OCT) provides tissue-specific contrast that enables airway smooth muscle (ASM) detection and quantification. Aim: Assess ASM content with PS-OCT in healthy and diseased airways. Methods: In vivo OCT imaging was performed in healthy volunteers, asthma and fibrotic interstitial lung diseases (fILD) patients. Standard OCT imaging was combined with PS-OCT birefringence and optical axis determination to detect, segment and quantify ASM. Results: 24 airways were imaged from distal to proximal (650-1000 cross-sectional images per airway) in 2 healthy volunteers, 2 asthma and 2 fILD patients. Standard OCT shows separate airway wall layers. PS-OCT enabled ASM segmentation in healthy and diseased airways (asthma and fILD). Preliminary results show an increase in ASM in diseased airways compared to healthy controls (Figure). Conclusion: Endobronchial PS-OCT is a minimally invasive imaging technique to identify airway wall layers with detection and quantification of ASM mass in both healthy and diseased airways. Implication: Endobronchial PS-OCT airway imaging is a promising tool to investigate airway wall remodeling in a minimally invasive way over full-length airway segments.
{"title":"Endobronchial polarization sensitive optical coherence tomography for airway wall imaging","authors":"Sofi Vassileva, Pieta C. Wijsman, Tatiana Soldati, Margherita Vaselli, Annika W.M. Goorsenberg, Daniel M. De Bruin, Johannes F. De Boer, Jouke T. Annema, Peter I. Bonta","doi":"10.1183/13993003.congress-2023.oa4855","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.oa4855","url":null,"abstract":"<b>Introduction:</b> The gold standard to assess airway wall composition is by invasive focal biopsies. Endobronchial optical coherence tomography (EB-OCT) generates in vivo real-time high resolution images of the airways. Polarization sensitive OCT (EB-PS-OCT) provides tissue-specific contrast that enables airway smooth muscle (ASM) detection and quantification. <b>Aim:</b> Assess ASM content with PS-OCT in healthy and diseased airways. <b>Methods:</b> In vivo OCT imaging was performed in healthy volunteers, asthma and fibrotic interstitial lung diseases (fILD) patients. Standard OCT imaging was combined with PS-OCT birefringence and optical axis determination to detect, segment and quantify ASM. <b>Results:</b> 24 airways were imaged from distal to proximal (650-1000 cross-sectional images per airway) in 2 healthy volunteers, 2 asthma and 2 fILD patients. Standard OCT shows separate airway wall layers. PS-OCT enabled ASM segmentation in healthy and diseased airways (asthma and fILD). Preliminary results show an increase in ASM in diseased airways compared to healthy controls (Figure). <b>Conclusion:</b> Endobronchial PS-OCT is a minimally invasive imaging technique to identify airway wall layers with detection and quantification of ASM mass in both healthy and diseased airways. <b>Implication:</b> Endobronchial PS-OCT airway imaging is a promising tool to investigate airway wall remodeling in a minimally invasive way over full-length airway segments. ","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136194439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa2283
Laura C. Bell, Alexandre Fernandez Coimbra, Yixuan Zou, Colin Dimond, Jaime Mata, John Muglar, Yun Michael Shim, David Mummy, Bastiaan Driehuys, Yuh-Chin Huang, Peter Niedbalski, Mario Castro, Yonni Friedlander, Norm Konyer, Sarah Svenningsen, Parameswaran Nair, Terence Ho, Andrew Hahn, Sean Fain, Eric A. Hoffman, Guilhem J. Collier, Jim M. Wild, Robert Thormen, Talissa Altes, Paula Belloni
Background: Sensitive markers of COPD progression are needed. Xe-MRI ventilation defect % (VDP) and gas-exchange metrics (membrane/gas (MDP), red-blood-cells/gas (RDP)) may be more sensitive to early progression than current clinical endpoints. Objectives: 1) Validate a harmonized Xe-MRI protocol in multicenter setting, and 2) Evaluate suitability of Xe-MRI metrics as measures of progression and predictors of acute exacerbations (AEx). Methods: Effectiveness of a Xe-MRI protocol for Siemens and GE MRI systems [1] was tested in healthy volunteers (HV) at 7 sites with a standardized quality check via a reproducibility assessment. Patient cohorts (n = 11 ongoing) included GOLD II-IV with history of AEx treated with SOC ± azithromycin, and GOLD I. Xe-MRI and PFTs were done at 0, 6, 12, 24, and 48 weeks. Quantitative CT exams at 0, 24 and 48 weeks for volume %normal, %emphysema, and %gas-trapping [2]. Results: In HVs homogeneous gas exchange and repeatability was observed (n = 5, r=0.98, p<.001). In COPD patients, baseline VDP correlated with FEV1 (-0.78, p<.05) and %normal CT (-0.72, p<.05). MDP correlated with %emphysema (0.81, p<.05). A GOLD III patient who experienced AExs and COVID during the 48 weeks showed an increase in MDP & RDP, and decrease in FEV1 (Fig1). Conclusions: A harmonized multicenter Xe-MRI protocol was successful. Early results in COPD patients show correlations between Xe-MRI, HRCT, and PFT.
{"title":"Multisite implementation of 129Xe-MRI assessment of COPD disease progression: XeCITE early results","authors":"Laura C. Bell, Alexandre Fernandez Coimbra, Yixuan Zou, Colin Dimond, Jaime Mata, John Muglar, Yun Michael Shim, David Mummy, Bastiaan Driehuys, Yuh-Chin Huang, Peter Niedbalski, Mario Castro, Yonni Friedlander, Norm Konyer, Sarah Svenningsen, Parameswaran Nair, Terence Ho, Andrew Hahn, Sean Fain, Eric A. Hoffman, Guilhem J. Collier, Jim M. Wild, Robert Thormen, Talissa Altes, Paula Belloni","doi":"10.1183/13993003.congress-2023.pa2283","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2283","url":null,"abstract":"<b>Background</b>: Sensitive markers of COPD progression are needed. Xe-MRI ventilation defect % (VDP) and gas-exchange metrics (membrane/gas (MDP), red-blood-cells/gas (RDP)) may be more sensitive to early progression than current clinical endpoints. <b>Objectives</b>: 1) Validate a harmonized Xe-MRI protocol in multicenter setting, and 2) Evaluate suitability of Xe-MRI metrics as measures of progression and predictors of acute exacerbations (AEx). <b>Methods</b>: Effectiveness of a Xe-MRI protocol for Siemens and GE MRI systems [1] was tested in healthy volunteers (HV) at 7 sites with a standardized quality check via a reproducibility assessment. Patient cohorts (n = 11 ongoing) included GOLD II-IV with history of AEx treated with SOC ± azithromycin, and GOLD I. Xe-MRI and PFTs were done at 0, 6, 12, 24, and 48 weeks. Quantitative CT exams at 0, 24 and 48 weeks for volume %normal, %emphysema, and %gas-trapping [2]. <b>Results</b>: In HVs homogeneous gas exchange and repeatability was observed (n = 5, r=0.98, p<.001). In COPD patients, baseline VDP correlated with FEV1 (-0.78, p<.05) and %normal CT (-0.72, p<.05). MDP correlated with %emphysema (0.81, p<.05). A GOLD III patient who experienced AExs and COVID during the 48 weeks showed an increase in MDP & RDP, and decrease in FEV1 (Fig1). <b>Conclusions</b>: A harmonized multicenter Xe-MRI protocol was successful. Early results in COPD patients show correlations between Xe-MRI, HRCT, and PFT.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136193317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background-aim: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has a negative impact on the prognosis of the disease. Radiological findings might be a helpful assessment tool to predict future exacerbations. Here we identified quantitative computerized tomography (CT) findings in relation to AECOPD. Methods: Thorax CT features of COPD patients who applied to our clinic during the last 5 years were retrospectively evaluated and analyzed based on voxel attenuation. Subjects were divided into two groups according to the presence of acute severe exacerbation during the last 12 months after the date of the CT scan. Thus, groups are named GOLD A-B and GOLD E according to GOLD 2023. Quantitative voxel-based attenuation analysis was done by Myrian® Expert software (Intrasense SA-1231, Montpellier, France). Emphysema was defined as attenuation values<-950 Hounsfield Unit (HU). Results: Of 106, 24 subjects had at least one severe AECOPD in the following year of CT. Emphysema percentage was significantly higher in GOLD E in the GOLD A-B group (3% vs 10%, p=0.001) (Table 1). However, both groups displayed similar values in lung volume and mean attenuation. Conclusion: Higher emphysema percentage might indicate increased AECOPD risk. Quantitative CT analysis could be a helpful assessment tool to evaluate exacerbation risk.
背景目的:慢性阻塞性肺疾病急性加重(AECOPD)对疾病的预后有负面影响。放射检查结果可能是预测未来恶化的有用评估工具。在这里，我们确定了与AECOPD相关的定量计算机断层扫描(CT)结果。方法:回顾性分析我院近5年COPD患者胸部CT表现，采用体素衰减法。根据CT扫描后12个月内是否存在急性严重恶化，将受试者分为两组。因此，根据《GOLD 2023》，分组被命名为GOLD A-B和GOLD e。基于体素的定量衰减分析由Myrian®Expert软件(Intrasense SA-1231，法国蒙彼利埃)完成。肺气肿定义为衰减值(Hounsfield Unit, HU)为-950。结果:106例患者中，24例患者在CT后一年至少发生一次严重AECOPD。在GOLD A-B组中，GOLD E组的肺气肿百分比明显更高(3% vs 10%， p=0.001)(表1)。然而，两组在肺体积和平均衰减方面显示相似的值。结论:肺气肿比例越高，AECOPD风险越高。定量CT分析可作为评估急性加重风险的有效评估工具。
{"title":"Radiologic features of COPD exacerbations: quantitative analysis of thorax computerised tomography","authors":"Selin Ercan, Ali Canturk, Emre Ruhat Avci, Naciye Sinem Gezer, Saliha Selin Ozuygur Ermis, Gozde Tokatli, Gokcen Omeroglu Simsek, Pinar Balci, Aylin Ozgen Alpaydin","doi":"10.1183/13993003.congress-2023.pa3998","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3998","url":null,"abstract":"<b>Background-aim:</b> Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has a negative impact on the prognosis of the disease. Radiological findings might be a helpful assessment tool to predict future exacerbations. Here we identified quantitative computerized tomography (CT) findings in relation to AECOPD. <b>Methods:</b> Thorax CT features of COPD patients who applied to our clinic during the last 5 years were retrospectively evaluated and analyzed based on voxel attenuation. Subjects were divided into two groups according to the presence of acute severe exacerbation during the last 12 months after the date of the CT scan. Thus, groups are named GOLD A-B and GOLD E according to GOLD 2023. Quantitative voxel-based attenuation analysis was done by Myrian® Expert software (Intrasense SA-1231, Montpellier, France). Emphysema was defined as attenuation values<-950 Hounsfield Unit (HU). <b>Results:</b> Of 106, 24 subjects had at least one severe AECOPD in the following year of CT. Emphysema percentage was significantly higher in GOLD E in the GOLD A-B group (3% vs 10%, <i>p</i>=0.001) (Table 1). However, both groups displayed similar values in lung volume and mean attenuation. <b>Conclusion:</b> Higher emphysema percentage might indicate increased AECOPD risk. Quantitative CT analysis could be a helpful assessment tool to evaluate exacerbation risk.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136201387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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