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Functional polymorphisms in the VEGF gene are not associated with age-related macular degeneration in a Mexican population VEGF基因的功能多态性与墨西哥人群中年龄相关性黄斑变性无关
Pub Date : 2020-05-25 DOI: 10.24875/rmoe.m20000106
Ramses Rosales-Díaz, A. Santos-García, J. Navarro-Partida, V. Benites-Godínez, Carlos Daniel Díaz-Palomera, A. D. Rodríguez-Carrizalez
introduction: The wet form of age-related macular degeneration (WAMD) is related to the expression of vascular endothelial growth factor (VEGF). Several single nucleotide polymorphisms (SNPs) in the VEGF gene are associated with different expression patterns of this cytokine (functional polymorphisms). In this study, we considered 4 SNPs that are located in the promoter region (rs699947 A/C, rs833061 C/T, rs1005230 C/T and rs1570360 A/G) and two in the 5’ untranslated region (rs2010963 C/G and rs25648 C/T) that have an effect on transcriptional regulation. Objective : To associate functional SNPs with WAMD in a Mexican population. Methods : Through allelic discrimination assays, consisting in polymerase chain reactions (PCR) with Taqman® probes, the polymorphisms were genotyped. Genotype frequencies were compared using all inheritance models. results : SNPs were genotyped in 105 patients diagnosed with WAMD (61 women and 44 men, mean age 74.28 ± 8.32 years), and in 102 healthy control subjects (61 women and 41 men, mean age 67.41 ± 5.78 years). Genotypes in both groups were in Hardy-Weinberg equilibrium. In all SNPs analyzed, the minor allele frequency was statistically significant different between the groups. Genotypes were not statistically significant different between the WAMD and the control groups (p > 0.05). conclusion : No association was observed between the studied SNPs and the presence of WAMD in the analyzed Mexican population. We consider that further analysis in larger samples is necessary to confirm these findings.
湿型老年性黄斑变性(WAMD)与血管内皮生长因子(VEGF)的表达有关。VEGF基因中的几个单核苷酸多态性(SNPs)与该细胞因子的不同表达模式(功能多态性)相关。在本研究中,我们考虑了位于启动子区(rs699947 A/C、rs833061 C/T、rs1005230 C/T和rs1570360 A/G)的4个snp和位于5 '非翻译区(rs2010963 C/G和rs25648 C/T)的2个snp对转录调控有影响。目的:在墨西哥人群中将功能性snp与WAMD联系起来。方法:采用Taqman®探针,采用聚合酶链反应(PCR)进行等位基因鉴别,对多态性进行基因分型。使用所有遗传模型比较基因型频率。结果:105例确诊为WAMD的患者(女性61例,男性44例,平均年龄74.28±8.32岁)和102例健康对照(女性61例,男性41例,平均年龄67.41±5.78岁)均进行了snp基因分型。两组基因型均符合Hardy-Weinberg平衡。在所有snp分析中,小等位基因频率在组间差异有统计学意义。WAMD组与对照组基因型差异无统计学意义(p > 0.05)。结论:在所分析的墨西哥人群中,未观察到所研究的snp与WAMD的存在之间的关联。我们认为有必要在更大的样本中进一步分析以证实这些发现。
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引用次数: 0
Strabismus in the north of Mexico: clinical characteristics in a pediatric population at public and private health institutions 墨西哥北部的斜视:公立和私立卫生机构儿科人口的临床特征
Pub Date : 2020-05-25 DOI: 10.24875/rmoe.m20000111
J. Páez-Garza, Andrea Rangel-Padilla, S. Gonzalez-Godinez, Sylvia de la Rosa-Pacheco
Introduction: Strabismus is one of the main causes of visual disability. Most cases are reversible with appropriate treatment; however, several factors can influence its diagnosis. Objective: To describe the demographic and clinical characteristics of strabismus in children from northern Mexico. Material and methods: We carried out a study to analyze the characteristics associated with strabismus in pediatric patients of a private hospital (Centro Médico Zambrano Hellion [CMZH]) and a primary care center (CeSI). Results: One-hundred and eighty nine patients were included. Median age at strabismus onset was 11 months, with a median age of 3.3 years when attending the clinic for the 1 st time, and the average time to seek medical care was of 13 months. Age of onset was higher in CMZH. However, the time it took patients to seek medical care was higher in CeSI (p < 0.001). The prevalence of amblyopia was significantly higher in CeSI (p = 0.007). Conclusions: This is the first study that describes the clinical and demographic characteristics associated with a diagnosis of strabismus in northern Mexico. Our results agree with other studies in Mexican and American populations. By analyzing the socioeconomic characteristics of the population, we conclude that it is of utmost importance to ensure that low-income population has access to specialized health services in order to receive an appropriate treatment.
斜视是视觉障碍的主要原因之一。大多数病例经适当治疗是可逆的;然而,有几个因素会影响其诊断。目的:描述墨西哥北部儿童斜视的人口学和临床特征。材料和方法:我们进行了一项研究,分析私立医院(Centro m dico Zambrano Hellion [CMZH])和初级保健中心(CeSI)儿科患者斜视的相关特征。结果:纳入189例患者。斜视发病时的中位年龄为11个月,首次就诊时的中位年龄为3.3岁,平均就医时间为13个月。CMZH的发病年龄较高。然而,CeSI患者寻求医疗护理所需的时间更长(p < 0.001)。弱视发生率在CeSI组明显高于CeSI组(p = 0.007)。结论:这是第一个描述与墨西哥北部斜视诊断相关的临床和人口统计学特征的研究。我们的结果与墨西哥和美国人群的其他研究结果一致。通过分析人口的社会经济特征,我们得出的结论是,确保低收入人口能够获得专门的保健服务,以便得到适当的治疗,这是至关重要的。
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引用次数: 0
Optic nerve melanocytoma: pathophysiology, clinical considerations, and diagnostic novelties 视神经黑素细胞瘤:病理生理学、临床考虑和诊断的新颖性
Pub Date : 2020-05-25 DOI: 10.24875/rmoe.m20000112
M. C. Estrada-Villarreal
Optic nerve melanocytoma is a rare, benign, pigmented tumor of the optic disc that may cause visual complications in few cases and can be easily confused with a malignant melanoma. This review aims to highlight its clinical characteristics and pathophysiology, as well as to update the diagnostic methods available, like optical coherence tomography angiography.
视神经黑色素细胞瘤是一种罕见的视盘良性色素肿瘤,少数病例可引起视觉并发症,容易与恶性黑色素瘤混淆。本文综述了其临床特征和病理生理,并对现有的诊断方法如光学相干断层血管造影进行了更新。
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引用次数: 0
Evaluation of the retina and optic nerve after the use of stem cells for neurodegenerative disorders in an animal model 在动物模型中使用干细胞治疗神经退行性疾病后视网膜和视神经的评估
Pub Date : 2019-11-06 DOI: 10.24875/rmoe.m19000086
R. García-Gil, A. Feliciano-Sánchez, L. Cubas-Núñez, J. Castillo-Villalba, Jorge Fuentes-Maestre, M. Fil, J. García-Verdugo, S. Gil-Perotín
Objective: To study the neuroprotective and neuroregenerative response of adult mesenchymal cells (aMSCs) on retinal ganglion cells (RGC) and optic nerve (ON) in an animal model of multiple sclerosis (MS) like experimental autoimmune encephalitis (EAE). Methods: We studied the changes that occurred in the retina and ON, analyzing the effect of an intravenous injection of aMSCs. Three groups were studied: healthy (control), sick (EAE) and sick treated with aMSCs (EAE-MSC). The animals were monitored using motor disability scales. The retinas and ONs were studied with optical microscopy, immunofluorescence and electron microscopy. Results: The results showed that after administration of intravenous aMSCs there was a lower loss of RGC, the average of RGC in the EAE group was of 0.0891 μm compared to 0.166 μm in the EAE-MSC group, with a statistically significant p value (p = 0.01). There was a reduction in the inflammatory cell response of the ON (7.99 cells/μm2 vs. 3.69 cells/μm2, p < 0.0001), a decrease of myelin loss (overall axonal damage was of 54% compared to 88%) and less axonal destruction (0.16745 axons/μm2 vs. 0.3598 axons/μm2 (p = 0.0251). Conclusions: In this study, we found that after the administration of aMSCs there was a lower loss of RGC, a decrease of myelin loss and a lower degree of inflammation in the ON. However, it would be advisable to expand the methodology to ensure an immunosuppressive and neuroprotective effect in this model.
目的:研究成人间充质细胞(aMSCs)对实验性自身免疫性脑炎(EAE)样多发性硬化症(MS)动物模型视网膜神经节细胞(RGC)和视神经(on)的神经保护和神经再生作用。方法:观察视网膜和ON的变化,分析静脉注射aMSCs对视网膜和ON的影响。分为健康组(对照组)、患病组(EAE组)和用aMSCs治疗的患病组(EAE- msc组)。用运动障碍量表对这些动物进行监测。采用光学显微镜、免疫荧光显微镜和电子显微镜对视网膜和神经网络进行观察。结果:静脉注射aMSCs后RGC的损失较低,EAE组RGC的平均值为0.0891 μm, EAE- msc组为0.166 μm, p值差异有统计学意义(p = 0.01)。ON的炎症细胞反应降低(7.99个细胞/μm2比3.69个细胞/μm2, p < 0.0001),髓磷脂损失减少(总轴突损伤为54%比88%),轴突破坏减少(0.16745个轴突/μm2比0.3598个轴突/μm2 (p = 0.0251)。结论:在本研究中,我们发现给药aMSCs后,RGC的损失较低,髓鞘的损失减少,ON的炎症程度较低。然而,为了确保在该模型中具有免疫抑制和神经保护作用,建议扩展方法。
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引用次数: 0
Retinopathy of valsalva secondary to bulimia nervosa: revision of the treatment with laser Nd-YAG 神经性贪食症继发valsalva视网膜病变:激光Nd-YAG治疗的改进
Pub Date : 2019-11-06 DOI: 10.24875/rmoe.m19000090
Julia Fajardo-Sanchez, Pilar Rojas-Lozano, Carlos E. Chau-Ramos
19-year-old male under treatment for bulimia came for sudden decrease of the visual acuity (VA) of the left eye (LE) after an episode of severe vomit. The LE vision was of hand motion and the fundus showed a sub internal limiting membrane (subILM) hemorrhage of 14 disc diameters. We decided to use Nd-YAG laser on the membrane, obtaining the complete drainage of the hemorrhage and immediate recovery of the LE VA (20/20). Conclusion: Nd-YAG laser treatment is recommended for young and active patients in cases of sub-ILM hemorrhage in the context of Valsalva’s retinopathy, due to its effective results
19岁男性贪食症患者因严重呕吐后左眼视力突然下降而就诊。视屏显示手部运动,眼底显示14个椎间盘直径的内限制膜出血。我们决定在膜上使用Nd-YAG激光,获得出血完全引流和LE VA立即恢复(20/20)。结论:Nd-YAG激光治疗年轻活跃的Valsalva视网膜病变亚ilm出血患者疗效显著,值得推荐
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引用次数: 0
Choroidal detachment. Epidemiological and ultrasound characteristics in an Ophthalmological center in Mexico City 脉络膜的超然。墨西哥城某眼科中心的流行病学和超声特征
Pub Date : 2019-11-06 DOI: 10.24875/rmoe.m19000087
Mª Soledad Barlatey, Robert Graciano-Díaz, Rebeca Devereux-García, Mariana Takane-Imay, Wilson Koga-Nakamura, M. C. González-González
Background: To describe the ultrasound features and disease history of patients with a diagnosis of choroidal detachment evaluated in the Ultrasound Department of the Instituto de Oftalmología “Fundación Conde de Valenciana IAP” of Mexico City from January 2015 to December 2017. Design: Observational, descriptive and retrospective. Methods: All the medical records with a diagnosis of choroidal detachment by ultrasound were analyzed. Exclusion criteria were missing and/or incomplete records. The information obtained was classified by causal disease, type, shape and extension of the choroidal detachment. Results: One hundred and forty-one patients were studied (89 [63.1%] men and 52 [36.9%] women). The average age was 52.92 years in men and 60.98 years in women. Cases related to inflammatory diseases were the most common (76 cases [53.9%]). A total of 102 cases (72.3%) showed a serous choroidal detachment. From all the serous choroidal detachments, 74 cases (52.5%) were observed as flat elevations and 87 cases (61.7%) affected more than six meridians. The average intraocular pressure was 7.63 mmHg. Conclusions: Ultrasound characteristics (shape, type and extension) of choroidal detachments depend on the cause. Flat detachments (mostly inflammatory) show a serous content and extend less than 6 dia-meters, while hemorrhagic detachments (mainly traumatic) tend to be dome-shaped and have a greater extension.
背景:描述2015年1月至2017年12月在墨西哥城Oftalmología“Fundación Conde de Valenciana IAP”超声科评估的诊断为脉络膜脱离的患者的超声特征和病史。设计:观察性、描述性和回顾性。方法:对所有超声诊断为脉络膜脱离的病历进行分析。排除标准缺失和/或记录不完整。所得信息按病因、脉络膜脱离的类型、形状和延伸程度进行分类。结果:共纳入141例患者,其中男性89例(63.1%),女性52例(36.9%)。男性平均年龄52.92岁,女性平均年龄60.98岁。炎症相关疾病最常见(76例[53.9%])。102例(72.3%)表现为严重的脉络膜脱离。浆液性脉络膜脱离中,74例(52.5%)表现为平抬高,87例(61.7%)表现为6条以上经络。平均眼压为7.63 mmHg。结论:脉络膜脱离的超声特征(形态、类型和延伸)与病因有关。扁平型脱离(多为炎症性)表现为浆液性内容物,延伸小于6米,而出血性脱离(多为创伤性)往往呈圆顶状,延伸更广。
{"title":"Choroidal detachment. Epidemiological and ultrasound characteristics in an Ophthalmological center in Mexico City","authors":"Mª Soledad Barlatey, Robert Graciano-Díaz, Rebeca Devereux-García, Mariana Takane-Imay, Wilson Koga-Nakamura, M. C. González-González","doi":"10.24875/rmoe.m19000087","DOIUrl":"https://doi.org/10.24875/rmoe.m19000087","url":null,"abstract":"Background: To describe the ultrasound features and disease history of patients with a diagnosis of choroidal detachment evaluated in the Ultrasound Department of the Instituto de Oftalmología “Fundación Conde de Valenciana IAP” of Mexico City from January 2015 to December 2017. Design: Observational, descriptive and retrospective. Methods: All the medical records with a diagnosis of choroidal detachment by ultrasound were analyzed. Exclusion criteria were missing and/or incomplete records. The information obtained was classified by causal disease, type, shape and extension of the choroidal detachment. Results: One hundred and forty-one patients were studied (89 [63.1%] men and 52 [36.9%] women). The average age was 52.92 years in men and 60.98 years in women. Cases related to inflammatory diseases were the most common (76 cases [53.9%]). A total of 102 cases (72.3%) showed a serous choroidal detachment. From all the serous choroidal detachments, 74 cases (52.5%) were observed as flat elevations and 87 cases (61.7%) affected more than six meridians. The average intraocular pressure was 7.63 mmHg. Conclusions: Ultrasound characteristics (shape, type and extension) of choroidal detachments depend on the cause. Flat detachments (mostly inflammatory) show a serous content and extend less than 6 dia-meters, while hemorrhagic detachments (mainly traumatic) tend to be dome-shaped and have a greater extension.","PeriodicalId":348732,"journal":{"name":"Revista Mexicana de Oftalmología (English Edition)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114055447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Horner´s syndrome with iris heterochromia 先天性霍纳综合征伴虹膜异色
Pub Date : 2019-11-06 DOI: 10.24875/rmoe.m19000091
M. Molero-Senosiaín, L. Salazar-Quiñones, I. Camacho-Bosca, Álvaro Corrales-Benítez, E. Santos-Bueso
{"title":"Congenital Horner´s syndrome with iris heterochromia","authors":"M. Molero-Senosiaín, L. Salazar-Quiñones, I. Camacho-Bosca, Álvaro Corrales-Benítez, E. Santos-Bueso","doi":"10.24875/rmoe.m19000091","DOIUrl":"https://doi.org/10.24875/rmoe.m19000091","url":null,"abstract":"","PeriodicalId":348732,"journal":{"name":"Revista Mexicana de Oftalmología (English Edition)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115940058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and risk factors of retinopathy of prematurity in the Lic. Adolfo López Mateos Regional Hospital, ISSSTE 中国早产儿视网膜病变发病率及危险因素分析。阿道夫López马特奥斯地区医院,ISSSTE
Pub Date : 2019-11-06 DOI: 10.24875/rmoe.m19000088
Dora A. Ochoa-Araujo, Vanesa Flores-Peredo, Jessica T. Romero-Martínez, N. Martinez–Rodriguez, Óscar Medina-Contreras
{"title":"Incidence and risk factors of retinopathy of prematurity in the Lic. Adolfo López Mateos Regional Hospital, ISSSTE","authors":"Dora A. Ochoa-Araujo, Vanesa Flores-Peredo, Jessica T. Romero-Martínez, N. Martinez–Rodriguez, Óscar Medina-Contreras","doi":"10.24875/rmoe.m19000088","DOIUrl":"https://doi.org/10.24875/rmoe.m19000088","url":null,"abstract":"","PeriodicalId":348732,"journal":{"name":"Revista Mexicana de Oftalmología (English Edition)","volume":"113 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121045954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National plan for detection and treatment of retinopathy of prematurity 国家早产儿视网膜病变检测与治疗方案
Pub Date : 2019-11-06 DOI: 10.24875/rmoe.m19000089
L. P. Orozco-Gómez
We present a historical summary of the work performed by the Sociedad Mexicana de Oftalmología, the ROP Mexico Group and the Ministry of Health for the development of the national plan for detection and treatment of premature retinopathy.
我们对墨西哥社会组织Oftalmología、ROP墨西哥小组和卫生部在制定国家早发性视网膜病变检测和治疗计划方面所做的工作进行历史总结。
{"title":"National plan for detection and treatment of retinopathy of prematurity","authors":"L. P. Orozco-Gómez","doi":"10.24875/rmoe.m19000089","DOIUrl":"https://doi.org/10.24875/rmoe.m19000089","url":null,"abstract":"We present a historical summary of the work performed by the Sociedad Mexicana de Oftalmología, the ROP Mexico Group and the Ministry of Health for the development of the national plan for detection and treatment of premature retinopathy.","PeriodicalId":348732,"journal":{"name":"Revista Mexicana de Oftalmología (English Edition)","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126115996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periorbital emphysema following dental procedure: A case report and literature review 牙科手术后眶周肺气肿:1例报告及文献复习
Pub Date : 2019-09-02 DOI: 10.24875/rmoe.m19000077
M. Rodríguez-Calzadilla, M. García-Vázquez, María Contreras-Espuny, Alejandro Soto-Guerrero, A. Rodríguez-Suárez, Francisco Javier Benítez-del-Castillo-Sánchez, Manuel García-Íñiguez
Clinical case: The case concerns a 57-year-old woman who came to the Ophthalmology Emergency Service referred by her dentist after presenting a left periorbital swelling during a root canal treatment. A complete examination only revealed a soft, smooth periorbital tumefaction, crackling on palpation, with no associated inflammation. No radiological examinations were performed. Discussion: Subcutaneous emphysema has been described as a rare complication in the usual dental practice. Periorbital involvement is exceptional and usually has a good prognosis. In this paper, we describe a new case, reviewing the literature on the subject, analyzing the pathophysiology of the process and the changes in its epidemiology. Furthermore, recommendations for their management are established.
临床病例:该病例涉及一名57岁妇女,她在根管治疗期间出现左眼眶周围肿胀,由牙医转诊至眼科急诊。完整检查仅发现柔软、光滑的眶周肿胀,触诊时有脆裂,无相关炎症。未做放射学检查。讨论:皮下肺气肿已被描述为一种罕见的并发症,在通常的牙科实践。眼眶周围受累是罕见的,通常预后良好。在本文中,我们描述了一个新病例,回顾了有关该主题的文献,分析了该过程的病理生理和流行病学的变化。此外,还对其管理提出了建议。
{"title":"Periorbital emphysema following dental procedure: A case report and literature review","authors":"M. Rodríguez-Calzadilla, M. García-Vázquez, María Contreras-Espuny, Alejandro Soto-Guerrero, A. Rodríguez-Suárez, Francisco Javier Benítez-del-Castillo-Sánchez, Manuel García-Íñiguez","doi":"10.24875/rmoe.m19000077","DOIUrl":"https://doi.org/10.24875/rmoe.m19000077","url":null,"abstract":"Clinical case: The case concerns a 57-year-old woman who came to the Ophthalmology Emergency Service referred by her dentist after presenting a left periorbital swelling during a root canal treatment. A complete examination only revealed a soft, smooth periorbital tumefaction, crackling on palpation, with no associated inflammation. No radiological examinations were performed. Discussion: Subcutaneous emphysema has been described as a rare complication in the usual dental practice. Periorbital involvement is exceptional and usually has a good prognosis. In this paper, we describe a new case, reviewing the literature on the subject, analyzing the pathophysiology of the process and the changes in its epidemiology. Furthermore, recommendations for their management are established.","PeriodicalId":348732,"journal":{"name":"Revista Mexicana de Oftalmología (English Edition)","volume":"77 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130634701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Revista Mexicana de Oftalmología (English Edition)
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