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Networks of Statisticians and the Transformation of Medicine 统计学家网络与医学转型
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.PHILLIPS
Christopher J Phillips
There is a statistical paradox at the heart of twentieth-century medicine. In 1900 physicians largely ignored the tools of statistical analysis. Clinicians and laboratory researchers saw themselves as fundamentally opposed to the burgeoning field of academic statistics: they were interested in biomedical causation, statisticians were focused on numerical correlation; they were focused on exceptions and idiosyncrasies, statisticians were focused on norms and averages; they were determinists, statisticians were probabilists. There were essentially no statistical articles in medical journals, no statistical training required for the M.D., no well-known statistical interpretations of laboratory experiments. The American Medical Association lamented that questions about therapeutic efficacy were largely addressed by anecdotal accounts from influential physicians (and drug companies themselves).1 The burgeoning field of public health (sometimes under the title of “sanitation” or “hygiene”) drew on epidemiological measures of disease, and questions of inoculation and epidemic infection had long been resolved with statistical calculations.2 But these were seen as limited to large outbreaks where people could be treated as interchangeable; in the clinic, the opposite was true. Patients were unique and the aggregative methods of epidemiology irrelevant.3 By 2000 the situation was seemingly reversed. A statistically significant randomized clinical trial was the gold standard of therapeutic efficacy, and such proof was required by the Food and Drug Administration (FDA) prior to licensing drugs.4 Reformers now promoted “evidence-based” medicine (as if medicine had never before been based on evidence), an initiative which claimed best practices should be determined solely on the basis of statistically
20世纪医学的核心存在一个统计悖论。在1900年,医生在很大程度上忽视了统计分析工具。临床医生和实验室研究人员认为自己从根本上反对新兴的学术统计领域:他们对生物医学因果关系感兴趣,统计学家专注于数字相关性;他们关注的是例外和特质,统计学家关注的是规范和平均值;他们是决定论者,统计学家是概率论者。医学期刊上基本上没有统计学文章,医学博士不需要统计学培训,也没有众所周知的实验室实验的统计学解释。美国医学协会遗憾地说,关于治疗效果的问题主要是由有影响力的医生(以及制药公司自己)的轶事叙述来解决的新兴的公共卫生领域(有时被称为"卫生"或"卫生")利用了疾病的流行病学措施,接种和流行病感染的问题早就用统计计算来解决了但这些被视为仅限于大规模疫情,在那里人们可以被视为可互换的;在诊所里,情况正好相反。患者具有独特性,流行病学的综合方法不适用到2000年,情况似乎发生了逆转。统计上显著的随机临床试验是治疗效果的黄金标准,在批准药物之前,食品和药物管理局(FDA)需要这样的证据改革者现在提倡“循证”医学(好像医学以前从来没有以证据为基础),这是一项倡议,声称最佳做法应该完全根据统计来确定
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引用次数: 0
Foreward 前方
Pub Date : 2018-12-14 DOI: 10.21061/viral-networks.reznick
J. Reznick
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引用次数: 0
Using Data and Network Analysis in Humanities Research: A Guide to Getting Started 在人文研究中使用数据和网络分析:入门指南
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.PORTER
N. Porter
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引用次数: 0
Glossary of Network Terminology 网络术语表
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.GLOSSARY
N. Porter
Actor In an affiliation network, the people or other entities tied by events Asymmetrical tie An edge or relationship in a directed network that is not reciprocated; for example Bob cites Jane but Jane does not cite Bob Affiliation network A network where the edges consisted of a shared characteristic, such as attending a class together, rather than a direct relationship, such as friendship, and the nodes are the actors and events; actors cannot be directly tied to other actors, nor events to other events Attribute A characteristic of a node or edge; can be used to select nodes and edges or as an analytic variable; can also be represented visually through size, color, etc. Bipartite network A network where ties occur only between (and not within) two distinct subgroups; affiliation networks are a type of bipartite networks Betweenness centrality A type of node centrality measuring the importance of each node in geodesic paths between other nodes Centralization A network statistic measuring how unevenly spread the edges in a network are; a network with high centralization has relatively few key nodes connecting a large number of other nodes Clique A subgroup of nodes where each node shares an edge with every other node; the most restrictive subgroup definition Closeness centrality A type of node centrality determined by the geodesic distance to all other nodes in a component; high closeness indicates that most other nodes can be reached in relatively few steps
行动者在从属网络中,被事件联系在一起的人或其他实体不对称的联系在有向网络中没有回报的边缘或关系;例如Bob引用了Jane,但Jane没有引用Bob的关联网络这种网络的边缘由共同的特征组成,比如一起上课,而不是直接的关系,比如友谊,节点是演员和事件;参与者不能直接绑定到其他参与者,事件也不能直接绑定到其他事件。属性节点或边缘的特征;可用于选择节点和边或作为解析变量;也可以通过尺寸、颜色等直观地表示。双部网络:只在两个不同的子群之间(而不在其内部)有联系的网络;隶属网络是二部网络的一种。中间中心性是一种节点中心性,衡量每个节点在其他节点之间的测地线路径中的重要性。中心化是一种网络统计,衡量网络中边缘分布的不均匀程度;在高度集中化的网络中,连接大量其他节点的关键节点相对较少。Clique每个节点与其他节点共享一条边的节点的子组;接近中心性由组件中所有其他节点的测地线距离决定的一种节点中心性;高接近度表示可以在相对较少的步骤中到达大多数其他节点
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引用次数: 0
Networks of the Unnamed and Medical Interventions in Colonial Cameroon 喀麦隆殖民地的无名者和医疗干预网络
Pub Date : 2018-12-14 DOI: 10.21061/viral-networks.runcie
S. Runcie
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引用次数: 0
Mapping Early Epidemiology: Concepts of Causality in Reports of the Third Plague Pandemic, 1894–1950 绘制早期流行病学:1894-1950年第三次鼠疫大流行报告中的因果关系概念
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.ENGELMANN
Lukas Engelmann
The science of epidemiology has always had an intricate relationship to the history of diseases. The design of models of the dynamics that govern diseases in their relation to population is ultimately based on information and data gathered from past outbreaks. Epidemiology belongs to what Lorraine Daston has recently called “Sciences of the Archive.”1 Like astronomy, zoology, demography, or meteorology, the study of epidemics operates with objects of superhuman scale. The discipline deals with plagues that exceed historiographical periods and geographical regions; and, thus, it always requires elaborated practices of collecting, accounting, and archiving to establish its status as a discipline. Daston reminds us that despite this reliance of some “hard” sciences on the historical record, their conduct of history often differs from the perspective of humanists on the same historical event. Where exegesis, commentary, and interpretation of contexts and niches might characterize a history of diseases and epidemics, the epidemiological grasp on the historical record seeks to collect quantifiable data. But epidemiology wasn’t always a science of mathematical analysis, concerned with the production of formal expressions and the elaborate design of stochastic models. The epidemiology of the late nineteenth and early twentieth centuries is best described as a broad interdisciplinary project, suspended between isolated academics in medical schools and a growing group of governmental medical officers applying a mixture of methods, integrating
流行病学一直与疾病的历史有着错综复杂的关系。控制疾病与人口关系的动力学模型的设计最终是基于从过去疫情中收集的信息和数据。流行病学属于洛林·达斯顿最近所说的“档案科学”。像天文学、动物学、人口学或气象学一样,对流行病的研究也涉及到超乎人类的范围。该学科研究超越历史时期和地理区域的瘟疫;因此,它总是需要详细的收集、核算和存档的实践来建立它作为一门学科的地位。达斯顿提醒我们,尽管一些“硬科学”依赖于历史记录,但它们对历史的研究往往与人文主义者对同一历史事件的看法不同。对背景和环境的注释、评论和解释可能是疾病和流行病历史的特征,而流行病学对历史记录的把握则寻求收集可量化的数据。但流行病学并不总是一门数学分析的科学,它关注的是正式表达式的产生和随机模型的精心设计。19世纪末和20世纪初的流行病学被最好地描述为一个广泛的跨学科项目,在医学院的孤立学者和越来越多的政府医疗官员之间暂停使用混合方法,整合
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引用次数: 1
Anatomical Reading of Correspondence: A Case Study of Epistolary Analysis Networks 书信的解剖阅读:书信分析网络的个案研究
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.COTTLE
Katherine Cottle
The recent transition from paper to electronic form as the standard means of communication has shifted not only the medium of epistolary expression, but also the networking potential of scholars and historians. Visualizations of networks can no longer rely solely on humanistic expectations of time, space, direction, and location with regards to communication, even when reading and studying text from pre-digital times. As personal print text becomes more and more indistinguishable from public digital communication, we find ourselves at a crossroads in finding appropriate venues for representing words that relate “a momentary experience which incorporates but stands outside orthodox conceptions of material and immaterial existence.”1 How do we, as current correspondents, scholars, and researchers, imbed standardized networking frameworks, such as traditional mapping, into current and future networking needs and applications? How can data-driven networks help to increase accessibility and knowledge of past figures and texts while simultaneously sustaining humanistic foundations, ethics, and aims? The Viral Networks workshop provided the time, physical and virtual space, guidance, and digital resources for me to explore these questions through networking applications of a recently discovered archive of personal correspondence, “The Esther Richards Letters, 1915–1932,” included within my forthcoming book, The Hidden Heart of Charm City: Baltimore Letters and Lives (AH/ Loyola University Maryland).
最近从纸质到电子作为标准通信手段的转变不仅改变了书信体的表达媒介,也改变了学者和历史学家的网络潜力。网络的可视化不再仅仅依赖于人文对交流的时间、空间、方向和位置的期望,即使在阅读和研究前数字时代的文本时也是如此。随着个人印刷文本与公共数字交流变得越来越难以区分,我们发现自己正处于一个十字路口,需要寻找合适的场所来表达与“一种瞬间体验”相关的词语,这种体验融合了物质和非物质存在的正统概念,但又站在它们之外。作为当前的通讯员、学者和研究人员,我们如何将标准化的网络框架(如传统的映射)嵌入到当前和未来的网络需求和应用中?数据驱动的网络如何帮助增加对过去人物和文本的可访问性和知识,同时维持人文基础、伦理和目标?病毒网络研讨会为我提供了时间、物理和虚拟空间、指导和数字资源,让我通过最近发现的个人通信档案的网络应用来探索这些问题,“埃丝特·理查兹信件,1915-1932”,包括在我即将出版的书中,魅力城市的隐藏之心:巴尔的摩信件和生活(AH/马里兰洛约拉大学)。
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引用次数: 0
Thinking about Sources as Data: Reflections on Epistemic Network Analysis as a Technique for Historical Research 把资料当作资料来思考:对作为历史研究技术的认知网络分析的思考
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.DIMEO-RUIS
Michelle DiMeo, A. Ruis
Network models, in particular social network models, have improved our understanding of a variety of historical phenomena, including correspondence communities, trade networks, citation patterns, dissemination of news, and so on. In many cases, social network analysis has been used to show relationships among people—who corresponded with, traded with, cited, or otherwise interacted with whom? But what if we extended our scope to consider the networks of knowledge created by these individuals? Instead of asking merely “Who was in this network and how were they connected?”, we could ask, “How did information move through this network?” Such questions more closely model the qualitative questions that historians concerned with discourse and concepts have traditionally asked and usually try to answer without computational approaches; however, as access to historical data is expanding rapidly due to digitization efforts, it will be useful, if not necessary, to collaborate with machines on our analyses. To do so, we need to think about mixed-methods approaches that integrate the strengths of humans and computers, and network analysis is one methodological approach that could prove helpful in answering the kinds of qualitative research questions often asked by social, cultural, and intellectual historians.1 In this chapter we reflect on the use of epistemic network analysis (ENA) as a tool for modeling conceptual networks. Because there are a number of resources that explain ENA in great detail as a
网络模型,特别是社会网络模型,提高了我们对各种历史现象的理解,包括通信社区、贸易网络、引文模式、新闻传播等。在许多情况下,社会网络分析被用来显示人与人之间的关系——谁与谁通信,与谁交易,与谁引用,或与谁互动?但是,如果我们把我们的范围扩大到考虑由这些个人创造的知识网络呢?不要仅仅问“谁在这个网络中,他们是如何连接的?”,我们可以问,“信息是如何通过这个网络传递的?”这些问题更接近于关注话语和概念的历史学家传统上提出的定性问题,并且通常试图在没有计算方法的情况下回答这些问题;然而,由于数字化的努力,对历史数据的访问正在迅速扩大,如果没有必要,与机器合作进行分析将是有用的。要做到这一点,我们需要考虑将人类和计算机的优势结合起来的混合方法方法,而网络分析是一种方法方法,可以证明它有助于回答社会、文化和智力历史学家经常提出的各种定性研究问题在本章中,我们将反思认识论网络分析(ENA)作为概念网络建模工具的使用。因为有许多资源非常详细地将ENA解释为
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引用次数: 0
Introduction: Connecting Digital Humanities and Medical History through Viral Networks 导言:通过病毒网络连接数字人文和医学史
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.EWING-RANDALL
E. Ewing, Katherine Randall
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引用次数: 0
"A Rather Straightforward Problem": Unravelling Networks of Segregation in Alabama’s Psychiatric Hospitals, 1966–1972 “一个相当直截了当的问题”:揭露阿拉巴马州精神病院的隔离网络,1966-1972
Pub Date : 2018-12-14 DOI: 10.21061/VIRAL-NETWORKS.SMITH
Kylie Smith
Racism in American psychiatry can be traced back to the intellectual justifications for slavery, and the early linkage of the black psyche with criminality.1 The idea that the African American was inherently psychologically inferior, less complex, more childlike, or just inherently “bad,” gave rise to centuries of neglect, abuse, and misdiagnosis of black people with mental illness, as well as justifying a system of separate and unequal treatment.2 In Alabama, this system legally ended on February 11, 1969 when the Honorable Judge Frank M. Johnson, Chief Judge of the US District Court in the Middle District of Alabama, handed down his decision in what he called “a rather straightforward problem” in the case of Marable v. Alabama Mental Health Board. In this decision, Johnson laid out in plain detail the many ways in which the State of Alabama and the Alabama Mental Health Board were in breach of Title VI of the Civil Rights Act of 1964, and declared racial segregation in the state’s mental hospitals unconstitutional. Judge Johnson gave the Alabama Mental Health Board 12 months to desegregate its inpatient facilities entirely, or it would continue to have its federal mental health funding withheld and would not be eligible for any further such funds.3 In the context of the powerful Civil Rights Movement in Alabama, mental hospitals became sites of contested ideas about the nature of African American psychology and a challenge to the racist nature of American psychiatry itself. This chapter is part of a much broader project called “Jim Crow in the Asylum: Psychiatry and Civil Rights in the American South,”
美国精神病学中的种族主义可以追溯到奴隶制的理性辩护,以及黑人精神与犯罪的早期联系认为非裔美国人在心理上天生低人一等、不那么复杂、更孩子气或天生就是“坏”的观点,导致了几个世纪以来对黑人精神疾病患者的忽视、虐待和误诊,也为隔离和不平等待遇制度提供了理由在阿拉巴马州,这一制度于1969年2月11日在法律上结束,当时阿拉巴马州中区美国地方法院首席法官弗兰克·m·约翰逊(Frank M. Johnson)法官在马拉布尔诉阿拉巴马州精神健康委员会一案中宣布了他所谓的“相当直截了当的问题”的判决。在这项判决中,约翰逊详细地阐述了阿拉巴马州和阿拉巴马州精神健康委员会违反1964年民权法案第六章的许多方面,并宣布该州精神病院的种族隔离违宪。约翰逊法官给了阿拉巴马精神健康委员会12个月的时间,要求其完全取消住院设施的种族隔离,否则将继续扣留其联邦精神健康资金,并且不再有资格获得任何此类资金在阿拉巴马州声势浩大的民权运动的背景下,精神病院成为关于非裔美国人心理本质的争议之地,也是对美国精神病学本身种族主义本质的挑战。这一章是一个更广泛的项目的一部分,名为“收容所中的吉姆·克劳:美国南方的精神病学和民权”,
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引用次数: 0
期刊
Viral Networks
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