{"title":"Bilateral Alive Tubal Ectopic Pregnancy","authors":"L. Khan","doi":"10.23880/mjccs-16000247","DOIUrl":"https://doi.org/10.23880/mjccs-16000247","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"199 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121886125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Metastatic transitional cell carcinoma in the penis is extremely rare. Symptoms like penile pain, swelling, or priapism should raise the suspicion, when they happen in a known case of invasive bladder cancer. Case presentation: We report an unusual case of penile pain and swelling in a 69-year-old man, known to have invasive bladder cancer that was initially treated with radiotherapy. Although both penile ultrasound and MRI suspected hematoma or scarring rather than malignancy, the penile biopsy confirmed metastatic transitional cell carcinoma. Conclusion: Metastatic urothelial carcinoma in the penis is a rare presentation with poor prognosis, where treatment options are very limited and mainly palliative.
{"title":"Primary High Grade Muscle Invasive Bladder Urothelial Carcinoma with Metastasis to the Penis Sparing the Urethra- A Case Presentation and Review of Literature","authors":"Emara S","doi":"10.23880/mjccs-16000320","DOIUrl":"https://doi.org/10.23880/mjccs-16000320","url":null,"abstract":"Background: Metastatic transitional cell carcinoma in the penis is extremely rare. Symptoms like penile pain, swelling, or priapism should raise the suspicion, when they happen in a known case of invasive bladder cancer. Case presentation: We report an unusual case of penile pain and swelling in a 69-year-old man, known to have invasive bladder cancer that was initially treated with radiotherapy. Although both penile ultrasound and MRI suspected hematoma or scarring rather than malignancy, the penile biopsy confirmed metastatic transitional cell carcinoma. Conclusion: Metastatic urothelial carcinoma in the penis is a rare presentation with poor prognosis, where treatment options are very limited and mainly palliative.","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124991177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Usage of Mobile Phone Applications for Dietary Benefits: Perceptions among Dietetics Professionals and Clients in Saudi Arabia","authors":"B. Alkhudairi","doi":"10.23880/mjccs-16000233","DOIUrl":"https://doi.org/10.23880/mjccs-16000233","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133916112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ayurvedic Management of Schizoaffective Disorder, Maniac Type – A Case Report","authors":"Jithesh M","doi":"10.23880/mjccs-16000278","DOIUrl":"https://doi.org/10.23880/mjccs-16000278","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133565237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beta-Caryophyllene, an Anti-Inflammatory Natural Compound, Improves Cognition in an Elderly Group who has Concerns about Memory","authors":"Stacey J Bell","doi":"10.23880/mjccs-16000300","DOIUrl":"https://doi.org/10.23880/mjccs-16000300","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114639610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adenoid Cystic Carcinoma of Breast: A Rare Entity","authors":"F. Huda","doi":"10.23880/mjccs-16000238","DOIUrl":"https://doi.org/10.23880/mjccs-16000238","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"101 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132225892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Idiopathic Scrotal Calcinosis: A Case Report","authors":"Pandiaraja J","doi":"10.23880/mjccs-16000299","DOIUrl":"https://doi.org/10.23880/mjccs-16000299","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133611620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single Ventricle Physiology with Double Outlet and TGA: 3D Cardiac MDCT as a Picture-Perfect Diagnostic Modality","authors":"K. Vora","doi":"10.23880/mjccs-16000315","DOIUrl":"https://doi.org/10.23880/mjccs-16000315","url":null,"abstract":"","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"505 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126991992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pancreatic neuroendocrine tumour is derived from neuroendocrine cells of pancreas or hormone secreting cells within vicinity of pancreas and is categorized into indolent well differentiated neuroendocrine tumour (WDNET) and the aggressive, rapidly progressive poorly differentiated neuroendocrine carcinoma(PDNEC). Well differentiated neuroendocrine tumour (WDNET) demonstrates inactivation of MEN1, genetic mutation or loss of DAXX / ATRX, altered mTOR pathway, incrimination of PTEN, TSC2, PIK3CA genes with alteration of VHL. Poorly differentiated neuroendocrine carcinoma and mixed neuroendocrine / non neuroendocrine neoplasm delineates alterations within TP53, RB, KRAS, APC, BRAF or SMAD4 / DPC4 genes. Neuroendocrine tumour delineates an organoid architecture with solid nests, trabeculae, gyri, cords, festoons, ribbons, glandular, pseudoacinar or tubulo-acinar articulations. Miniature to intermediate tumour cells are permeated with eosinophilic, amphophilic, finely granular cytoplasm, centric, spherical to elliptical, uniform nuclei with finely stippled ‘salt and pepper’ nuclear chromatin, inconspicuous nucleoli and an abundant circumscribing vascular network. Pancreatic neuroendocrine tumour is immune reactive to CK8 / CK18, CAM 5.2, OSCAR, AE1 / AE3, synaptophysin, chromogranin A, INSM1, CD56, neuron specific enolase (NSE) or CD57. Pancreatic neuroendocrine tumour pancreas requires segregation from neoplasms such as acinar cell carcinoma, pancreatoblastoma, solid pseudo-papillary neoplasm, pancreatic ductal adenocarcinoma, paraganglioma, clear cell tumours as clear cell sarcoma, metastatic renal cell carcinoma, PEComa or solid variant of serous cystadenoma. Comprehensive surgical eradication is recommended for treating well differentiated neuroendocrine tumour. Poorly differentiated neuroendocrine tumour is appropriately treated with platinum based chemotherapy.
{"title":"Secrete and Exude-Pancreatic Neuroendocrine Tumour","authors":"B. A","doi":"10.23880/mjccs-16000331","DOIUrl":"https://doi.org/10.23880/mjccs-16000331","url":null,"abstract":"Pancreatic neuroendocrine tumour is derived from neuroendocrine cells of pancreas or hormone secreting cells within vicinity of pancreas and is categorized into indolent well differentiated neuroendocrine tumour (WDNET) and the aggressive, rapidly progressive poorly differentiated neuroendocrine carcinoma(PDNEC). Well differentiated neuroendocrine tumour (WDNET) demonstrates inactivation of MEN1, genetic mutation or loss of DAXX / ATRX, altered mTOR pathway, incrimination of PTEN, TSC2, PIK3CA genes with alteration of VHL. Poorly differentiated neuroendocrine carcinoma and mixed neuroendocrine / non neuroendocrine neoplasm delineates alterations within TP53, RB, KRAS, APC, BRAF or SMAD4 / DPC4 genes. Neuroendocrine tumour delineates an organoid architecture with solid nests, trabeculae, gyri, cords, festoons, ribbons, glandular, pseudoacinar or tubulo-acinar articulations. Miniature to intermediate tumour cells are permeated with eosinophilic, amphophilic, finely granular cytoplasm, centric, spherical to elliptical, uniform nuclei with finely stippled ‘salt and pepper’ nuclear chromatin, inconspicuous nucleoli and an abundant circumscribing vascular network. Pancreatic neuroendocrine tumour is immune reactive to CK8 / CK18, CAM 5.2, OSCAR, AE1 / AE3, synaptophysin, chromogranin A, INSM1, CD56, neuron specific enolase (NSE) or CD57. Pancreatic neuroendocrine tumour pancreas requires segregation from neoplasms such as acinar cell carcinoma, pancreatoblastoma, solid pseudo-papillary neoplasm, pancreatic ductal adenocarcinoma, paraganglioma, clear cell tumours as clear cell sarcoma, metastatic renal cell carcinoma, PEComa or solid variant of serous cystadenoma. Comprehensive surgical eradication is recommended for treating well differentiated neuroendocrine tumour. Poorly differentiated neuroendocrine tumour is appropriately treated with platinum based chemotherapy.","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121790417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Retronychia is a specific form of proximal perionyxis with chronic evolution.If not known the diagnostic can be difficult.The treatment is surgical and does not recur once treated with avulsion. Herein, we report a new case that exhibited persistent perionyxis in a 46-year-old woman.
{"title":"Chronic Perionyxis: Is there a Hidden Nail?","authors":"K. Moustaide","doi":"10.23880/mjccs-16000231","DOIUrl":"https://doi.org/10.23880/mjccs-16000231","url":null,"abstract":"Retronychia is a specific form of proximal perionyxis with chronic evolution.If not known the diagnostic can be difficult.The treatment is surgical and does not recur once treated with avulsion. Herein, we report a new case that exhibited persistent perionyxis in a 46-year-old woman.","PeriodicalId":356296,"journal":{"name":"Medical Journal of Clinical Trials & Case Studies","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125725014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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