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[Scale Development on Perception of Academic Harassment among Medical University Faculties]. 医科大学教师对学术骚扰认知的量表开发
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18033
Toru Nagasawa, Kyoko Nomura, Shinichi Takenoshita, Haruko Hiraike, Akiko Tsuchiya, Takayoshi Ohkubo, Hiroko Okinaga

Objectives: In academia, harassment may often occur and remain unrevealed in Japan, which discourages young researchers from pursuing their career. It is necessary to estimate and improve the perception of "academic harassment" among university faculties. Therefore, in this study, we aim to develop a scale of perception of academic harassment.

Methods: Prior to a quantitative survey, a task team consisting of medical doctors, researchers, nurses, hospital workers, and managers in general affairs division identified 36 items related to academic harassment. In February 2016, we sent a self-administered questionnaire to 1,126 academic faculty members who worked in a medical university located in Tokyo, Japan. We instructed them to score the extent to which they consider each item as related to academic harassment based on a Likert scale. We carried out maximum likelihood factor analyses with promax rotation and computed Cronbach's alpha to develop a scale and investigate the reliability of the scale.

Results: In total, 377 returned the questionnaires (response rate, 33.5%; male, 73.8%). In factor analyses, we removed 17 items owing to low factor loadings, and four factors were eventually extracted. The first factor was termed "Harassment in organization (7 items)" because it included conditions of forcing a particular person to work on chores or lectures for students that may prevent one's academic research outputs. The second factor was termed "Violence and denying personal character (4 items)". The third factor was termed "Research misconduct (5 items)" including conditions of excluding a particular person from the coauthor list of research outputs or pressuring a person to fabricate, falsify, or plagiarize research outputs. The fourth factor was termed "Research interference (3 items)" including a condition of interference with conference attendance. Cronbach's alpha values of these four factors ranged from 0.83 to 0.91, suggesting that the scale had high reliability. The means of these factors did not differ according to gender but were higher in participants aged 50 or older than in younger participants.

Conclusions: The results suggest that the scale of perception on academic harassment consisting of four factors with 19 items is valid and reliable to some extent.

目标:在学术界,骚扰可能经常发生,并且在日本仍然没有被揭露,这阻碍了年轻研究人员追求他们的事业。有必要评估和改善大学教师对“学术骚扰”的认知。因此,在本研究中,我们的目标是开发一个学术骚扰感知量表。方法:在进行定量调查之前,由医生、研究人员、护士、医院工作人员和综合科管理人员组成的任务小组确定了与学术骚扰有关的36个项目。2016年2月,我们向位于日本东京的一所医科大学的1126名教员发送了一份自我管理的问卷。我们指示他们根据李克特量表对他们认为每个项目与学术骚扰相关的程度进行评分。我们进行了最大似然因子分析,并计算了Cronbach's alpha,以开发量表并调查量表的可靠性。结果:共回收问卷377份,回复率33.5%;男性,73.8%)。在因子分析中,由于因子负荷低,我们删除了17个项目,最终提取了4个因素。第一个因素被称为“组织骚扰(7项)”,因为它包括强迫某个人做家务或为学生讲课,这可能会妨碍他的学术研究成果。第二个因素被称为“暴力和否认人格(4项)”。第三个因素被称为“研究不端行为(5项)”,包括将特定人员排除在研究成果的共同作者名单之外,或迫使某人捏造、伪造或剽窃研究成果。第四个因素被称为“研究干扰(3项)”,包括干扰会议出席的条件。这四个因素的Cronbach’s alpha值在0.83 ~ 0.91之间,表明量表具有较高的信度。这些因素的平均值没有因性别而异,但在50岁或以上的参与者中高于年轻参与者。结论:研究结果表明,由4个因素组成的学术骚扰感知量表具有一定的效度和信度。
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引用次数: 1
[Evaluation of the Performance of Health Systems by Prefecture]. [地方卫生系统绩效评价]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18028
Hisato Nakajima, Kouya Yano

Objectives: To clarify the performance of health systems (performance), the state of prefectures was investigated.

Methods: Using the method developed by the Organisation for Economic Co-operation and Development, we conducted the study using 27 indicators. To evaluate the performance, we examined the signal-to-noise ratio of transcription (η) by integrating indicators using the Mahalanobis-Taguchi method. The η was separated by a median. The ratio of prefectures in East or West Japan and the presence or absence of ordinance-designated cities were studied using the chi-square test. Furthermore, the correlation among the total component η (T-η), each component η, and expenditures, and the correlation between T-η and life expectancy, were studied.

Results: The T-η positively correlated with the risk factors (RF)-η and the resources (R)-η, and negatively correlated with the health status (HS)-η. The number pf prefectures without ordinance-designated cities where the T-η and RF-η exceeded the median was large. The number of prefectures with ordinance-designated cities where the HS-η exceeded the median was also large. In addition, there were many prefectures where the T-η was in the top 25% in West Japan. There were positive correlations between the total expenditures and the T-η, the expenditures and the RF-η, and the expenditures and the R-η. There was a negative correlation between the expenditures and the HS-η, and the T-η and the life expectancy.

Conclusions: For life expectancy, prefectures with too good performance were recognized. In these prefectures, correction of resources is necessary.

目的:为了明确卫生系统的绩效(绩效),对各州进行了调查。方法:采用经济合作与发展组织制定的方法,采用27个指标进行研究。为了评估其性能,我们使用Mahalanobis-Taguchi方法通过整合指标来检测转录的信噪比(η)。η用中位数隔开。使用卡方检验研究了东、西日本县的比例和条例指定城市的存在与否。进一步研究了总组分η (T-η)、各组分η与支出以及T-η与预期寿命的相关性。结果:T-η与危险因素(RF)-η和资源(R)-η呈正相关,与健康状况(HS)-η负相关。T-η和RF-η超过中位数的非法令指定城市的县数量很大。HS-η值超过中位数的县级市数量也很大。此外,西日本有许多县的T-η在前25%。总支出与T-η、支出与RF-η、支出与R-η呈显著正相关。支出与HS-η呈负相关,与T-η呈负相关。结论:在预期寿命指标上,表现较好的县得到了认可。在这些县,资源的修正是必要的。
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引用次数: 0
[Demographic Characteristics of Foreign Residents in Japan; Child Maltreatment and Language Problems in Child Protection Services]. 日本外国居民的人口特征;儿童保护服务中的虐待儿童及语言问题]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18032
Naomi Kitano, Kumsun Lee, Yasuhide Nakamura

In this study, we examined the changes in the demographic characteristics of foreign residents in Japan (FRJ) and the current status of FRJ from a global health perspective. We also considered child maltreatment that occurred in FRJ families and language problems in child welfare. Japan's official statistics in the end of 2017 indicated that there were more than 2.56 million FRJ from over 190 countries. This population was diverse with heterogeneous characteristics, such as age structure, dwelling place, marital status, and childbirth. At the end of 2017, there were 219,982 FRJ children aged 0-14 of various nationalities, including Chinese, Brazilian, South Korean, North Korean, Filipino, Vietnamese, Peruvian, Nepalese, and Indian. In 2010, we conducted our first survey of child maltreatment in FRJ families, targeting 219 child protection centers across Japan. Between April 2007 and August 2010, 1,639 child maltreatment cases were reported from 56% of these centers. Details of 1,111 cases were collected and descriptive analyses were conducted. The male-to-female ratio was 0.88 and the median age was 8 years: however, the age distribution showed that females were significantly older than males (P < 0.01). The proportions of physical abuse, child neglect, emotional abuse, and sexual abuse were 38%, 33%, 21%, and 7%, respectively. Native language problems created numerous challenges and required a large amount of effort from child welfare practitioners. However, most solutions to identified problems were still at the beginning stage and some were found to be ineffective. More interdisciplinary and integrated researches are needed targeting child welfare of FRJ. An ethical framework for good counseling practices should be developed.

在这项研究中,我们从全球健康的角度考察了日本外国居民(FRJ)的人口统计学特征的变化和FRJ的现状。我们还考虑了FRJ家庭中发生的儿童虐待和儿童福利中的语言问题。2017年底,日本官方统计数据显示,共有来自190多个国家的256万多名FRJ。该人群具有年龄结构、居住地、婚姻状况、生育等异质性特征。截至2017年底,共有219,982名0-14岁的FRJ儿童,他们来自不同的国家,包括中国、巴西、韩国、朝鲜、菲律宾、越南、秘鲁、尼泊尔和印度。2010年,我们对FRJ家庭的儿童虐待问题进行了首次调查,调查对象是全日本219个儿童保护中心。2007年4月至2010年8月期间,56%的中心报告了1,639起虐待儿童案件。收集了1111例病例的详细资料并进行了描述性分析。男女性别比为0.88,年龄中位数为8岁,但年龄分布上女性明显大于男性(P < 0.01)。身体虐待、忽视儿童、精神虐待和性虐待的比例分别为38%、33%、21%和7%。母语问题带来了许多挑战,需要儿童福利工作者付出大量努力。然而,大多数已发现问题的解决方案仍处于起步阶段,有些被发现是无效的。针对FRJ儿童福利问题,需要开展更多跨学科、综合性的研究。应制定良好咨询做法的道德框架。
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引用次数: 2
[Significant Birthdays of Pettenkofer and Koch Celebrated in Germany]. [佩滕科弗和科赫的重要生日在德国庆祝]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.19002
Toshio Matsushita, Beate Wonde
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引用次数: 0
[Examination of Regional Differences in Performance of Health Systems by Prefecture Using Cluster Analysis]. [基于聚类分析的地区卫生系统绩效差异研究]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.19009
Hisato Nakajima, K. Yano
OBJECTIVE The Organisation for Economic Co-operation and Development (OECD) pointed out the deterioration of the performance of health systems (performance) in Japan. To correct this, we evaluated the performances in different prefectures. METHODS By the OECD method, we set 27 indicators concerning "health status (HS)", " risk factors (RFs)", " access to care (AC)", " quality of care (QC)", and " health care resources (HRs)". Next, the relative value (RV, ±4 standard deviation) from the average value of each indicator in each prefecture was obtained. On the basis of this RV, the prefectures were divided into A, B, and C by cluster analysis. Then, the 27 indicators of the three groups were subjected to multiple comparison tests and the performances were evaluated. RESULTS A included Hokkaido, Ishikawa, Kyoto, Shimane, Okayama, Hiroshima, Yamaguchi, Tokushima, Kagawa, Ehime, Kochi, Fukuoka, Saga, Nagasaki, Kumamoto, Oita, Miyazaki, Kagoshima, and Okinawa, B included Aomori, Iwate, Akita, Fukushima, Ibaraki, Tochigi, Saitama, Tokyo, Osaka, and Wakayama, C included Miyagi, Yamagata, Gunma, Chiba, Kanagawa, Niigata, Toyama, Fukui, Yamanashi, Nagano, Gifu, Shizuoka, Aichi, Mie, Shiga, Hyogo, Nara, and Tottori. The multiple comparison test results showed that HS and RFs were not significantly different between A and C. In A, AC and QC were poor, but HRs were excessive, and the local allocation tax was high. RFs, AC, QC, HRs, and the local allocation taxes were not significantly different between B and C, but HS was poor in B. CONCLUSIONS The performance of health systems was deteriorating in the 19 prefectures included in A, and correction is necessary in these prefectures.
目的经济合作与发展组织(OECD)指出了日本卫生系统绩效的恶化。为了纠正这一点,我们评估了不同县的表现。方法采用OECD方法,设置健康状况(HS)、危险因素(RFs)、医疗可及性(AC)、医疗质量(QC)、医疗资源(HRs)等27个指标。然后,从各县各指标的平均值得到相对值(RV,±4个标准差)。在此基础上,通过聚类分析将县划分为A、B、C三个县。然后,对三组27项指标进行多次比较检验,评价其性能。结果sa包括北海道、石川、京都、岛根、冈山、广岛、山口、德岛、香川、爱媛、高知、福冈、佐贺、长崎、熊本、大分、宫崎、鹿儿岛和冲绳,B包括青森、岩手、秋田、福岛、茨城县、枥木、埼玉、东京、大阪和和歌山,C包括宫城、山形、群马、千叶、神奈川、新潟、富山、福井、山梨县、长野、岐阜、静冈、爱知、Mie、志贺、兵库县、奈良和鸟取县。多重对比检验结果显示,A和c的HS和RFs差异不显著。A的AC和QC较差,但HRs过高,地方分配税较高。B、C地区的RFs、AC、QC、HRs和地方税差异不显著,但B地区的HS较差。结论A地区19个州的卫生系统绩效不断恶化,有必要进行整改。
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引用次数: 0
[Liver Fibrosis is Associated with Loss of Skeletal Muscle Mass in Community-Dwelling Older Adults with No History of Liver Diseases]. [肝纤维化与无肝病史的社区老年人骨骼肌质量损失相关]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18031
Shuhei Ohnishi, Nobuyuki Miyai, Miyoko Utsumi, Kanae Mure, Tatsuya Takeshita, Mitsuru Shiba, Mikio Arita

Objectives: In this study, we aimed to examine the possible association between liver fibrosis and loss of skeletal muscle mass (SM) in community-dwelling older adults with no history of liver diseases.

Methods: A total of 2,028 older adults (mean age, 69.8 ± 5.2 years) who had not received any treatment for liver diseases and had participated in a comprehensive health survey for community residents in Wakayama, Japan were included in this study. We carried out bioelectrical impedance analysis to estimate the SM of the whole body including the arms, legs, and trunk of the subjects. Liver fibrosis was evaluated by calculating the Fib4 index based on the subject's age, AST level, ALT level, and platelet counts.

Results: The subjects were divided into three groups according to cutoff values of the Fib4 index (low: <1.30, medium: 1.30-2.66, high: ≥2.67). The SM index (kg/m2) was the lowest among subjects in the high-Fib4-index category, followed by the medium- and low-Fib4-index categories. This dose-response reduction in the SM index was more pronounced among individuals with lower blood albumin level (low nutrition) and in those with more sedentary behavior (physical inactivity). Among the selected 262 subjects who underwent SM measurement twice with an interval of 3 years, the subjects with a high Fib4 index showed greater reduction in the SM index than those with medium and low Fib4 indices. Multiple regression analysis revealed that the Fib4 index was significantly associated with the SM index, independent of age, sex, albumin level, sedentary behavior, diabetes mellitus, alcohol intake, and smoking status.

Conclusions: The present findings suggest that the potential progression of liver fibrosis is associated with the excessive loss of SM among apparently healthy older adults without any treatment for liver diseases.

目的:在本研究中,我们旨在研究无肝病史的社区居住老年人肝纤维化与骨骼肌质量(SM)损失之间的可能关联。方法:研究对象为参加日本和歌山社区居民综合健康调查的未接受任何肝脏疾病治疗的2028名老年人(平均69.8±5.2岁)。我们进行了生物电阻抗分析来估计整个身体的SM,包括受试者的手臂、腿和躯干。根据受试者的年龄、AST水平、ALT水平和血小板计数计算Fib4指数来评估肝纤维化。结果:按照Fib4指数截断值将受试者分为三组(低:2),高Fib4指数组受试者最低,其次是中、低Fib4指数组。在血白蛋白水平较低(低营养)和久坐行为较多(缺乏身体活动)的个体中,SM指数的剂量反应降低更为明显。在选取的262名受试者中,间隔3年进行两次SM测量,高Fib4指数的受试者SM指数下降幅度大于中、低Fib4指数的受试者。多元回归分析显示,Fib4指数与SM指数显著相关,与年龄、性别、白蛋白水平、久坐行为、糖尿病、饮酒和吸烟状况无关。结论:目前的研究结果表明,在未接受任何肝脏疾病治疗的表面健康老年人中,肝纤维化的潜在进展与SM的过度丧失有关。
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引用次数: 2
[Toxic Components of PM2.5 and Their Toxicity Mechanisms-On the Toxicity of Sulfate and Carbon Components]. [PM2.5的有毒成分及其毒性机制——硫酸盐和碳成分的毒性研究]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.19004
M. Sagai
Recently, the main air pollutant has been fine particulate matter (PM2.5), which is taken up by the whole body with severe adverse health effects. The main chemical components of PM2.5 are salts of sulfate (and nitrate) and carbons. However, it remains unknown which components are toxic. Here, the author reviewed the literatures to determine which components are toxic and the main mechanisms underlying their toxicity. Many epidemiological studies have shown that sulfate concentration is strongly related to mortality. However, there is no experimental evidence showing that sulfate at environmental concentrations of PM2.5 causes cardiovascular disease or other disease. On the other hand, carbon components such as elementary carbon (EC) produces high concentrations of reactive oxygen species (ROS) via its phagocytosis by macrophages, and organic carbon (OC) also produces high concentrations of ROS during its metabolic processes, and the ROS cause acute and chronic inflammation. They cause many diseases including cardiovascular disease, asthma and cancer. Furthermore, there are many lines of evidence showing that epigenetic changes such as DNA methylation or microRNA expression induced by particulate matters also induce the development of many diseases such as those mentioned above. It has been reported that carbon components are incorporated into the brain and produce ROS, and that the ROS cause damage to brain cells and Alzheimer's disease and cognitive disorders in the elderly.From these lines of evidence, the author would like to emphasize that the main toxicity of PM2.5 is due to carbon components, and it is important to take countermeasures to decrease the concentration of carbon components in ambient air.
近年来,主要的空气污染物是细颗粒物(PM2.5),它被全身吸收,对健康有严重的不良影响。PM2.5的主要化学成分是硫酸盐(和硝酸盐)和碳。然而,目前尚不清楚哪些成分有毒。在此,作者回顾了文献,以确定哪些成分是有毒的,其毒性的主要机制。许多流行病学研究表明,硫酸盐浓度与死亡率密切相关。然而,没有实验证据表明PM2.5环境浓度下的硫酸盐会导致心血管疾病或其他疾病。另一方面,元素碳(EC)等碳组分通过巨噬细胞的吞噬作用产生高浓度的活性氧(ROS),有机碳(OC)在代谢过程中也产生高浓度的ROS,引起急性和慢性炎症。它们会导致许多疾病,包括心血管疾病、哮喘和癌症。此外,有许多证据表明,颗粒物质诱导的DNA甲基化或microRNA表达等表观遗传变化也会诱发上述许多疾病的发生。据报道,碳成分被纳入大脑并产生活性氧,活性氧引起脑细胞损伤和老年阿尔茨海默病和认知障碍。从这些证据中,作者想强调PM2.5的主要毒性是由于碳成分,采取对策降低环境空气中碳成分的浓度很重要。
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引用次数: 8
[Toward a Declaration to Address Japan's Aging Society with Low Birth Rate: Summary of the Japanese Society for Hygiene's Working Group on Academic Research Strategy against an Aging Society with Low Birth Rate]. [关于应对日本低生育老龄化社会的宣言:日本卫生学会低生育老龄化社会学术研究策略工作组摘要]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18034
Kyoko Nomura, Kanae Karita, Atsuko Araki, Emiko Nishioka, Go Muto, Miyuki Iwai-Shimada, Mariko Nishikitani, Mariko Inoue, Shinobu Tsurugano, Naomi Kitano, Mayumi Tsuji, Sachiko Iijima, Kayo Ueda, Michihiro Kamijima, Zentaro Yamagata, Kiyomi Sakata, Masayuki Iki, Hiroyuki Yanagisawa, Masashi Kato, Kazuhito Yokoyama, Akio Koizumi, Takemi Otsuki
1 秋田大学医学部公衆衛生学講座, 杏林大学医学部衛生学公衆衛生学・杏林大学男女共同参画推進室, 3 北海道大学環境健康科学研究教育センター, 防衛医科大学校医学教育部看護学科母性看護学講座, 順天堂大学医学部衛生学講座, 6 国立環境研究所環境リスク・健康研究センター, 九州大学持続可能な社会のための決断科学センター, 8 帝京大学大学院公衆衛生学研究科, 電気通信大学保健管理センター, 10 和歌山県立医科大学地域・国際貢献推進本部地域医療支援センター,医学部公衆衛生学講座, 産業医科大学医学部産業衛生学, 12 順天堂大学大学院医療看護学研究科, 京都大学地球環境学堂, 名古屋市立大学大学院医学研究科環境労働衛生学分野, 15 山梨大学大学院総合研究部医学域社会医学講座, 岩手医科大学衛生公衆衛生学講座, 近畿大学医学部公衆衛生学講座, 18 東京慈恵会医科大学環境保健医学講座, 名古屋大学大学院医学系研究科環境労働衛生学, 京都保健会, 21 川崎医科大学衛生学講座
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引用次数: 0
[Development of a New Resilience Scale for Parents of Children with Profound Intellectual and Multiple Disabilities]. [深度智力障碍和多重残疾儿童家长心理弹性量表的开发]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18025
Mio Tanaka, Mitsuru Hisata, Michio Miyasaka, Keiko Kurata, Kumiko Takizawa, Mayumi Nishikata, Jun Tohyama, Nao Seki

Objetives: As the first step forward building a supporting system for the Parents of Children with Profound Intellectual and Multiple Disabilities (PIMD) at home, we developed a new resilience scale that can be used by multiple professionals to understand the situation of those parents and to provide the necessary support.

Methods: First, we collected scale items on the basis of our previous study as well as related reports in the literature. These items were then screened by the research team with knowledge and experience in supporting those parents, finally, 37 items were generated. Then, we asked the parents of children with PIMD who were of elementary school age and above in the Kanto-Shinetsu area to complete a questionnaire. Out of 477 questionnaires sent, 193 were refused, and the data were statistically analyzed.

Results: Exploratory factor analysis revealed that the scale was made up of the following seven factors. 1) Understanding and awareness of the child, 2) Empowerment by the child, 3) Use of specialists, 4) Interest and concern in something other than the child, 5) Emotional adjustment, 6) Maintenance of lifestyle balance, and 7) Request for assistances. Cronbach's alpha coefficient of each factor was calculated. The validity was also confirmed by determining the relationship of resilience with parents' well-being.

Conclusions: The results suggest that the new resilience scale for parents of children with PIMD developed in this study can be a reliable instrument for assessing resilience in Japanese parents of a child with such disabilities.

目的:作为建立深度智力和多重残疾儿童(PIMD)家庭家长支持系统的第一步,我们开发了一种新的弹性量表,可以由多名专业人员使用,以了解这些父母的情况并提供必要的支持。方法:首先,我们在前期研究和相关文献报道的基础上收集量表条目。然后由具有知识和经验的研究团队对这些项目进行筛选,最终生成37个项目。然后,我们要求关东-新越地区小学及以上年龄的PIMD儿童的父母完成一份调查问卷。在477份问卷中,有193份被拒绝,并对数据进行统计分析。结果:探索性因子分析显示,量表由以下七个因素组成。1)对孩子的理解和认识,2)孩子的授权,3)使用专家,4)对孩子以外的事情感兴趣和关注,5)情绪调整,6)维持生活方式平衡,7)请求帮助。计算各因子的Cronbach’s alpha系数。通过确定心理弹性与父母幸福感的关系,也证实了本研究的有效性。结论:本研究编制的PIMD儿童父母心理弹性量表可作为评估日本PIMD儿童父母心理弹性的可靠工具。
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引用次数: 0
[Investigation of the Effects of Exposure to Chemical Substances on Child Health]. [接触化学物质对儿童健康影响的调查]。
Q3 Medicine Pub Date : 2019-01-01 DOI: 10.1265/jjh.18030
Miyuki Iwai-Shimada, Shoji F Nakayama, Tomohiko Isobe, Yayoi Kobayashi, Go Suzuki, Kyoko Nomura

There is mounting concern about the effects of early-life exposure to chemical substances on children's health and development. We summarize the past and ongoing birth cohort studies carried out worldwide on the association between environmental exposure and children's health. Our PubMed search with the keywords 'birth cohort' revealed that the number of articles jumped from 200-300 in the 1980s to over 1,000 in the 1990s. Many of these articles reported elevated risks to children's health posed by chemical exposure owing their vulnerability. At the same time, policies implemented to reduce exposure to lead and dioxins were successful in the past few decades. Research also demonstrated that intervention to reduce exposure to certain chemicals whose exposure routes were well documented was also successful. We summarize the effects of early-life exposure to chemical substances on children's health and development. Our findings will hopefully help safeguard the environment in which future generations grow and live.

人们越来越关注生命早期接触化学物质对儿童健康和发展的影响。我们总结了世界范围内关于环境暴露与儿童健康之间关系的过去和正在进行的出生队列研究。我们在PubMed上搜索关键词“出生队列”,发现文章数量从20世纪80年代的200-300篇跃升至90年代的1000多篇。其中许多文章报告说,由于儿童的脆弱性,接触化学品对他们的健康构成了更高的风险。与此同时,在过去几十年中,为减少接触铅和二恶英而实施的政策取得了成功。研究还表明,减少接触某些化学物质的干预措施也是成功的,这些化学物质的接触途径已得到充分记录。我们总结了生命早期接触化学物质对儿童健康和发展的影响。我们的发现有望有助于保护后代生长和生活的环境。
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引用次数: 2
期刊
Japanese Journal of Hygiene
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