Despite its high effectiveness, hematopoietic stem cell transplantation (HSCT) can sometimes be associated with multiple peri-transplant complications requiring urgent intervention. Life-threatening complications in the transplantation unit affect non-relapse mortality. This article sets out a practical approach to the essential peri-transplant clinical conditions, divided into infectious complications and complications related to immune response and endothelial damage. An early diagnosis of life-threatening conditions, and prompt implementation of the best therapy, can save patients’ lives. This is especially the case regarding infectious complications in neutropenic patients and in the advanced stages of immunological complications such as graft-versus-host disease, veno-occlusive disease, graft failure, diffuse alveolar hemorrhage, and thrombotic microangiopathy associated with HSCT. These emergencies are discussed below, along with their risk factors and a summary of the management of patients in the early post-transplant period.
{"title":"Emergencies in patients undergoing hematopoietic stem cell transplantation","authors":"Joanna Kujawska, Magdalena Matuszak, Lidia Gil","doi":"10.5603/ahp.96092","DOIUrl":"https://doi.org/10.5603/ahp.96092","url":null,"abstract":"Despite its high effectiveness, hematopoietic stem cell transplantation (HSCT) can sometimes be associated with multiple peri-transplant complications requiring urgent intervention. Life-threatening complications in the transplantation unit affect non-relapse mortality. This article sets out a practical approach to the essential peri-transplant clinical conditions, divided into infectious complications and complications related to immune response and endothelial damage. An early diagnosis of life-threatening conditions, and prompt implementation of the best therapy, can save patients’ lives. This is especially the case regarding infectious complications in neutropenic patients and in the advanced stages of immunological complications such as graft-versus-host disease, veno-occlusive disease, graft failure, diffuse alveolar hemorrhage, and thrombotic microangiopathy associated with HSCT. These emergencies are discussed below, along with their risk factors and a summary of the management of patients in the early post-transplant period.","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Fałkowska, Adam Jakubas, Laura Surdacka, Jakub Jagiełło, K. Drabko, A. Zaucha-Prażmo
{"title":"Safe use of fecal microbiota transplant in treatment of graft versus host disease in a 5-year-old child","authors":"A. Fałkowska, Adam Jakubas, Laura Surdacka, Jakub Jagiełło, K. Drabko, A. Zaucha-Prażmo","doi":"10.5603/ahp.95288","DOIUrl":"https://doi.org/10.5603/ahp.95288","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49606115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Szmydki-Baran, Mariusz Cieślak, Monika Mielcarek-Siedziuk, Krzysztof Kałwak, Paweł Łaguna
A case report of a patient with severe thalassemia alpha and concomitant hydrops fetalis (BHFS) was published by Skulimowska et al. [1] in the December 2019 issue of “Acta Haematologica Polonica”. A hypotrophic female preterm newborn
{"title":"Severe thalassemia alpha diagnosed and prenatally treated in Poland: clinical follow-up of case with more than one hematological disease","authors":"A. Szmydki-Baran, Mariusz Cieślak, Monika Mielcarek-Siedziuk, Krzysztof Kałwak, Paweł Łaguna","doi":"10.5603/ahp.95384","DOIUrl":"https://doi.org/10.5603/ahp.95384","url":null,"abstract":"A case report of a patient with severe thalassemia alpha and concomitant hydrops fetalis (BHFS) was published by Skulimowska et al. [1] in the December 2019 issue of “Acta Haematologica Polonica”. A hypotrophic female preterm newborn","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45848266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne Munzinger, Suruthie Sundrasan, Józef Kobos, Michał Golberg, D. Barańska, A. Lesiak, J. Narbutt, Joanna Trelińska
{"title":"Complicated paediatric Castleman disease treated with tocilizumab","authors":"Anne Munzinger, Suruthie Sundrasan, Józef Kobos, Michał Golberg, D. Barańska, A. Lesiak, J. Narbutt, Joanna Trelińska","doi":"10.5603/ahp.94453","DOIUrl":"https://doi.org/10.5603/ahp.94453","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42571175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Poland, the care of children with cancer and hematological diseases is provided within a single, very broad specialization in pediatric oncology and hematology. For almost all specialists, this is a second or subsequent specialization, while the specialization in pediatrics is a primary specialization. At present, 210 physicians have specialized in this niche field. There are 18 pediatric oncology and hematology centers in Poland. According to data from the National Consultant in Pediatric Oncology and Hematology, the total number of hospitalizations in pediatric oncohematology wards is about 31,000 annually. On an average working day in 18 pediatric oncology and hematology departments in Poland there are about 450 patients with malignant diseases (including patients after hematopoietic cell transplantation or cancer recurrence). Pediatric oncology is a discipline of rare diseases, as the incidence of pediatric malignancies is lower than 5 cases per 10,000 inhabitants annually [1]. The population of Poland in 2021 was 38.08 million, of whom 7.64 million (20.1%) were aged <18 years [2] (for comparison, in 1990 children accounted for 29% of the population of Poland). According to data from 2020, the number of new cases of cancers of the lymphatic, hematopoietic and related systems in Poland is c.8,100 per year, including c.450 in children (5.5%). In adults, leukemias and lymphomas each account for c.2% of all malignancies. 28% of all malignancies in children are leukemias (being the most common type of cancer) while lymphomas are c.13% [with a ratio of Hodgkin/non-Hodgkin lymphoma (HL/NHL) = 50%/50%] [3]. Myelodysplastic malignancies, chronic myeloproliferative neoplasms, and chronic myeloid leukemia in children are casuistic: for each of these, new diagnoses are fewer than 10 per year. The number of new histiocytoses in children is about 30 per year. Chronic lymphocytic leukemia and plasmocytic myeloma practically never occur in children. This issue of “Acta Haematologica Polonica” is focused on pediatric hematology and oncological hematology. Papers indicating current problems and trends in diagnostics and treatment in this field of medicine are presented, reflecting common problems for all hematologists [4–6].
{"title":"Pediatric hematooncology in Poland","authors":"Krzysztof Czyżewski, J. Styczyński","doi":"10.5603/ahp.96754","DOIUrl":"https://doi.org/10.5603/ahp.96754","url":null,"abstract":"In Poland, the care of children with cancer and hematological diseases is provided within a single, very broad specialization in pediatric oncology and hematology. For almost all specialists, this is a second or subsequent specialization, while the specialization in pediatrics is a primary specialization. At present, 210 physicians have specialized in this niche field. There are 18 pediatric oncology and hematology centers in Poland. According to data from the National Consultant in Pediatric Oncology and Hematology, the total number of hospitalizations in pediatric oncohematology wards is about 31,000 annually. On an average working day in 18 pediatric oncology and hematology departments in Poland there are about 450 patients with malignant diseases (including patients after hematopoietic cell transplantation or cancer recurrence). Pediatric oncology is a discipline of rare diseases, as the incidence of pediatric malignancies is lower than 5 cases per 10,000 inhabitants annually [1]. The population of Poland in 2021 was 38.08 million, of whom 7.64 million (20.1%) were aged <18 years [2] (for comparison, in 1990 children accounted for 29% of the population of Poland). According to data from 2020, the number of new cases of cancers of the lymphatic, hematopoietic and related systems in Poland is c.8,100 per year, including c.450 in children (5.5%). In adults, leukemias and lymphomas each account for c.2% of all malignancies. 28% of all malignancies in children are leukemias (being the most common type of cancer) while lymphomas are c.13% [with a ratio of Hodgkin/non-Hodgkin lymphoma (HL/NHL) = 50%/50%] [3]. Myelodysplastic malignancies, chronic myeloproliferative neoplasms, and chronic myeloid leukemia in children are casuistic: for each of these, new diagnoses are fewer than 10 per year. The number of new histiocytoses in children is about 30 per year. Chronic lymphocytic leukemia and plasmocytic myeloma practically never occur in children. This issue of “Acta Haematologica Polonica” is focused on pediatric hematology and oncological hematology. Papers indicating current problems and trends in diagnostics and treatment in this field of medicine are presented, reflecting common problems for all hematologists [4–6].","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47514928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Krasowska-Kwiecień, Agnieszka Dłużniewska, Katarzyna Smalisz, Oktawiusz Wiecha, Anna Zaniewska-Tekieli, Jolanta Goździk
{"title":"Hemophagocytic lymphohistiocytosis as an indication or sequelae of hematopoietic stem cell transplant in children: a single center experience","authors":"Aleksandra Krasowska-Kwiecień, Agnieszka Dłużniewska, Katarzyna Smalisz, Oktawiusz Wiecha, Anna Zaniewska-Tekieli, Jolanta Goździk","doi":"10.5603/ahp.95459","DOIUrl":"https://doi.org/10.5603/ahp.95459","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136162694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hereditary hemochromatosis and its complications in a girl with severe aplastic anemia","authors":"Ewa Pustelnik, Miłosz Rak, K. Pawelec","doi":"10.5603/ahp.95287","DOIUrl":"https://doi.org/10.5603/ahp.95287","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42687229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Secondary resistance to imatinib in child with chronic myeloid leukemia as result of mutations in BCR ABL-1 kinase domain","authors":"K. Pawelec, K. Albrecht","doi":"10.5603/ahp.a2023.0045","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0045","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48210535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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