Introduction: Hypertriglyceridemia (HTG) is one of the common complications of the regimens based on steroids and asparaginase used in the treatment of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in children. The aim of this cross-sectional retrospective study was the analysis of the prevalence, clinical course and management of hypertriglyceridemia following the administration of asparaginase and steroids according to the binding protocols. Material and methods: A cohort of 75 children with ALL or LBL was analyzed with reference to anthropometric and laboratory parameters, clinical symptoms, implemented treatment, and complications. Results: The prevalence of HTG in the analyzed cohort was 29.3%. Risk factors for HTG development were older age, cachexia and lower body mass index, but there was no correlation with high risk group. Patients with HTG presented with elevated lipase acivity and total cholesterol concentration and decreased antithrombin, albumin, sodium and high-density lipoprotein
{"title":"Hypertriglyceridemia associated with anticancer therapy based on asparaginase and steroids: a retrospective single center study of children with acute lymphoblastic leukemia and lymphoblastic lymphoma","authors":"A. Malecka, M. Hennig, N. Irga-Jaworska","doi":"10.5603/ahp.a2023.0040","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0040","url":null,"abstract":"Introduction: Hypertriglyceridemia (HTG) is one of the common complications of the regimens based on steroids and asparaginase used in the treatment of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in children. The aim of this cross-sectional retrospective study was the analysis of the prevalence, clinical course and management of hypertriglyceridemia following the administration of asparaginase and steroids according to the binding protocols. Material and methods: A cohort of 75 children with ALL or LBL was analyzed with reference to anthropometric and laboratory parameters, clinical symptoms, implemented treatment, and complications. Results: The prevalence of HTG in the analyzed cohort was 29.3%. Risk factors for HTG development were older age, cachexia and lower body mass index, but there was no correlation with high risk group. Patients with HTG presented with elevated lipase acivity and total cholesterol concentration and decreased antithrombin, albumin, sodium and high-density lipoprotein","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Nephrotoxicity, as a side effect of antineoplastic treatment, can occur in childhood cancer survivors (CCSs). It worsens their quality of life especially if it leads to chronic kidney disease (CKD). Collagen turnover is known to be disturbed in CKD. Urinary type IV collagen (U-Col4) is recognized as an exponent of extracellular matrix synthesis and degradation in glomeruli and is thus involved in this turnover. The purpose of this study was to evaluate the usefulness of U-Col4 in assessing early renal impairment in CCSs. Material and methods: Seventy-eight CCSs, without CKD, bilateral kidney tumors, congenital kidney defects, urinary tract infections and diabetes, at least one year after ending antineoplastic treatment, and aged 1–18 years, were divided into three groups: 1) patients after nephroblastoma treatment (n = 18); 2) patients after other solid tumors treatment (n = 42); and 3) patients after anti-hamatopoietic and lymphatic system proliferative treatment (n = 18). Concentrations of creatinine and cystatin C
{"title":"Is urinary type IV collagen a good marker of early impairment of renal function in childhood cancers survivors?","authors":"Michalina Jezierska, A. Owczarzak, J. Stefanowicz","doi":"10.5603/ahp.a2023.0038","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0038","url":null,"abstract":"Introduction: Nephrotoxicity, as a side effect of antineoplastic treatment, can occur in childhood cancer survivors (CCSs). It worsens their quality of life especially if it leads to chronic kidney disease (CKD). Collagen turnover is known to be disturbed in CKD. Urinary type IV collagen (U-Col4) is recognized as an exponent of extracellular matrix synthesis and degradation in glomeruli and is thus involved in this turnover. The purpose of this study was to evaluate the usefulness of U-Col4 in assessing early renal impairment in CCSs. Material and methods: Seventy-eight CCSs, without CKD, bilateral kidney tumors, congenital kidney defects, urinary tract infections and diabetes, at least one year after ending antineoplastic treatment, and aged 1–18 years, were divided into three groups: 1) patients after nephroblastoma treatment (n = 18); 2) patients after other solid tumors treatment (n = 42); and 3) patients after anti-hamatopoietic and lymphatic system proliferative treatment (n = 18). Concentrations of creatinine and cystatin C","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45155871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksander Siwek, Z. Skiba, M. Lejman, Joanna Zawitkowska
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Although in the past ALL was incurable, today’s survival rate is as high as 80–90%. The most important drugs in its treatment are glucocorticosteroids (GCS). This study focuses on exogenous GCS — dexamethasone and prednisolone, which suppress the hypothalamic–pituitary–adrenal (HPA) axis. The main objective of this study was to analyze articles about steroid side effects in ALL therapy, factors contributing to the frequency of HPA axis suppression, and possible methods for its assessment. According to research, abnormal cortisol values have been observed in almost every patient treated for ALL. This means it is important to perform HPA axis stimulation tests. In the reviewed studies, adrenal crisis, hyperglycemia, obesity, iatrogenic Cushing’s disease, growth failure, increased risk of infection, and a high mortality rate have been reported to be the most important complications of this therapy. It is important to note that some authors classify patients in terms of cortisol level disorder predispositions. These include the age and sex of the patient, the type of glucocorticoid used in ALL therapy, and the duration of the therapy.
{"title":"Abnormal cortisol levels in pediatric patients treated with glucocorticosteroids for acute lymphoblastic leukemia","authors":"Aleksander Siwek, Z. Skiba, M. Lejman, Joanna Zawitkowska","doi":"10.5603/ahp.a2023.0039","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0039","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Although in the past ALL was incurable, today’s survival rate is as high as 80–90%. The most important drugs in its treatment are glucocorticosteroids (GCS). This study focuses on exogenous GCS — dexamethasone and prednisolone, which suppress the hypothalamic–pituitary–adrenal (HPA) axis. The main objective of this study was to analyze articles about steroid side effects in ALL therapy, factors contributing to the frequency of HPA axis suppression, and possible methods for its assessment. According to research, abnormal cortisol values have been observed in almost every patient treated for ALL. This means it is important to perform HPA axis stimulation tests. In the reviewed studies, adrenal crisis, hyperglycemia, obesity, iatrogenic Cushing’s disease, growth failure, increased risk of infection, and a high mortality rate have been reported to be the most important complications of this therapy. It is important to note that some authors classify patients in terms of cortisol level disorder predispositions. These include the age and sex of the patient, the type of glucocorticoid used in ALL therapy, and the duration of the therapy.","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49298446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Urbański, B. Pawlik, W. Mlynarski, J. Trelińska
{"title":"Hematological toxicity of mTOR inhibitors is mild and dose-dependent in patients with tuberous sclerosis and subependymal giant cell astrocytoma","authors":"B. Urbański, B. Pawlik, W. Mlynarski, J. Trelińska","doi":"10.5603/ahp.a2023.0035","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0035","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44128058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Fałkowska, A. Zaucha-Prażmo, K. Drabko, Krzysztof Czyżewski, Oliwia Grochowska, Kamila Jaremek, Agnieszka Majk, P. Zalas-Więcek, J. Frąckiewicz, Małgorzata Salomonowicz-Bodzioch, M. Ussowicz, K. Kałwak, L. Chełmecka-Wiktorczyk, J. Gozdzik, J. Styczyński, J. Wachowiak, O. Zając‐Spychała
Introduction: Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is one of the therapeutic options in pediatric acute lymphoblastic leukemia (ALL)
简介：异基因造血干细胞移植（allo-HSCT）是儿童急性淋巴细胞白血病（ALL）的治疗选择之一
{"title":"Viral infections after hematopoetic stem cell transplantation in children with acute lymphoblastic leukemia: the Polish experience","authors":"A. Fałkowska, A. Zaucha-Prażmo, K. Drabko, Krzysztof Czyżewski, Oliwia Grochowska, Kamila Jaremek, Agnieszka Majk, P. Zalas-Więcek, J. Frąckiewicz, Małgorzata Salomonowicz-Bodzioch, M. Ussowicz, K. Kałwak, L. Chełmecka-Wiktorczyk, J. Gozdzik, J. Styczyński, J. Wachowiak, O. Zając‐Spychała","doi":"10.5603/ahp.a2023.0037","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0037","url":null,"abstract":"Introduction: Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is one of the therapeutic options in pediatric acute lymphoblastic leukemia (ALL)","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42852904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanna Stankiewicz, Ewa Demidowicz, Natalia Bartoszewicz, A. Kołtan, S. Koltan, Krzysztof Czyżewski, Monika Richert-Przygonska, R. Dębski, M. Pogorzała, Barbara Tejza, Joanna Cisek, Piotr Księżniakiewicz, Agnieszka Jatczak-Gaca, Marlena Salamon, Agata Marjańska, Anna H. Dąbrowska, E. Grześk, A. Urbańczyk, Kamila Jaremek, Monika Łęcka, Eugenia Winogrodzka, Monika Adamkiewicz, Dominika Kołuda, Sandra Wałach, Oliwia Grochowska, S. Tarasenko, Marta Mazalon, M. Dziedzic, M. Kubicka, Beata Kuryło-Rafińska, J. Styczyński
Introduction: Over recent decades, significant progress in the treatment of childhood acute myeloid leukemia (AML) has been made. However, the relapsed disease remains a challenge. The aim of this study was to analyze therapy results in pediatric patients treated for relapsed AML in a single oncology center
{"title":"Relapsed childhood acute myeloid leukemia: prognostic factors and outcomes: experience from a single oncology center","authors":"Joanna Stankiewicz, Ewa Demidowicz, Natalia Bartoszewicz, A. Kołtan, S. Koltan, Krzysztof Czyżewski, Monika Richert-Przygonska, R. Dębski, M. Pogorzała, Barbara Tejza, Joanna Cisek, Piotr Księżniakiewicz, Agnieszka Jatczak-Gaca, Marlena Salamon, Agata Marjańska, Anna H. Dąbrowska, E. Grześk, A. Urbańczyk, Kamila Jaremek, Monika Łęcka, Eugenia Winogrodzka, Monika Adamkiewicz, Dominika Kołuda, Sandra Wałach, Oliwia Grochowska, S. Tarasenko, Marta Mazalon, M. Dziedzic, M. Kubicka, Beata Kuryło-Rafińska, J. Styczyński","doi":"10.5603/ahp.a2023.0036","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0036","url":null,"abstract":"Introduction: Over recent decades, significant progress in the treatment of childhood acute myeloid leukemia (AML) has been made. However, the relapsed disease remains a challenge. The aim of this study was to analyze therapy results in pediatric patients treated for relapsed AML in a single oncology center","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45759837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomasz Styczyński, Jagoda Sadlok, Monika Richert-Przygonska, R. Dębski, Jan Syczyński, Krzysztof Czyżewski
{"title":"Invasive fungal disease presenting as septic shock in immunocompromised pediatric and adult patients: summary of reported cases","authors":"Tomasz Styczyński, Jagoda Sadlok, Monika Richert-Przygonska, R. Dębski, Jan Syczyński, Krzysztof Czyżewski","doi":"10.5603/ahp.a2023.0030","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0030","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41512315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Joks, Lidia Gil, J. Rupa-Matysek, Piotr Cieślak, Emil Durka, K. Lewandowski
{"title":"Rare entitity primary testicular lymphoma: a single-center analysis","authors":"M. Joks, Lidia Gil, J. Rupa-Matysek, Piotr Cieślak, Emil Durka, K. Lewandowski","doi":"10.5603/ahp.a2023.0027","DOIUrl":"https://doi.org/10.5603/ahp.a2023.0027","url":null,"abstract":"","PeriodicalId":35805,"journal":{"name":"Acta Haematologica Polonica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42121866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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