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Clinical effectiveness of autologous platelet rich fibrin in the management of infrabony periodontal defects 自体富血小板纤维蛋白治疗骨下牙周缺损的临床疗效观察
Q2 Medicine Pub Date : 2012-12-01 DOI: 10.1016/j.sdj.2012.10.003
V. Rosamma Joseph , Arun Raghunath , Nitin Sharma

Background

This interventional controlled clinical trial with split mouth design compares the clinical effectiveness of autologous platelet rich fibrin with open flap debridement in the management of infrabony periodontal defects.

Methods

Fifteen patients with paired contralateral infrabony defects were treated with open flap debridement and autologous platelet rich fibrin (experimental group) or open flap debridement alone (control group). The changes in probing pocket depth, clinical attachment level, and radiographic defect depth were evaluated. Patient perception regarding pain and discomfort following the procedures and early soft tissue healing responses were assessed by visual analog scales, scored 7 days after the surgical procedures. Final reevaluation was done 1 year after surgery.

Results

Baseline clinical and radiographic measurements were comparable between the groups. Reevaluation at 1 year revealed that both treatment modalities resulted in a significant decrease in probing pocket depth, gain in clinical attachment and radiographic bone fill of the defects compared to baseline. Postoperative differences observed between the two groups were 2.27±0.29 mm (P<0.001) for probing pocket depth, 3.33±0.35 mm (P<0.001) for clinical attachment level and 1.29±0.32 mm (P<0.001) for radiographic infrabony defect depth reduction, all in favor of the experimental group. Patient preference was greater and early healing response better for the experimental group as assessed by the visual analog scores.

Conclusion

Within the limitations of this study it can be concluded that use of platelet rich fibrin is more effective than open flap debridement alone in the management of infrabony periodontal defects.

本研究采用裂口设计,比较了自体富血小板纤维蛋白与开瓣清创治疗骨下牙周缺损的临床效果。方法对15例双侧对侧骨下缺损患者分别采用开放皮瓣清创联合自体富血小板纤维蛋白治疗(实验组)和单独开放皮瓣清创治疗(对照组)。评估探查袋深度、临床附着水平和影像学缺损深度的变化。手术后7天,通过视觉模拟量表评估患者对手术后疼痛和不适的感觉以及早期软组织愈合反应。术后1年复查。结果两组之间的基线临床和放射学测量具有可比性。1年后的重新评估显示,与基线相比,两种治疗方式都显著降低了探测袋深度,增加了临床附着和x线片上的骨填充缺损。两组术后探查袋深度差异为2.27±0.29 mm (P<0.001),临床附着水平差异为3.33±0.35 mm (P<0.001),影像学下骨缺损复位深度差异为1.29±0.32 mm (P<0.001),均优于实验组。通过视觉模拟评分评估,实验组患者的偏好更大,早期愈合反应更好。结论在本研究的局限性下,应用富血小板纤维蛋白治疗骨下牙周缺损比单纯开瓣清创更有效。
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引用次数: 40
Maxillofacial prosthodontic management of an ablative maxillary surgical defect using a combination of conventional obturator prosthesis and an early loading implant supported high-strength full ceramic fixed dental prosthesis 传统闭孔修复与早期负荷种植体支撑的高强度全陶瓷固定修复联合修复上颌消融手术缺损
Q2 Medicine Pub Date : 2012-12-01 DOI: 10.1016/j.sdj.2012.08.001
Ansgar C. Cheng , Ho Kok-Sen , Andrew Loy

Prosthodontic rehabilitation of maxillary defects and early loading of endosseous implants has been widely published. The combination of the aforementioned treatment modalities are seldom reported in peer reviewed journals. This article describes the clinical presentation, management and prosthodontic rehabilitation of the maxillary defect of a patient. Clinical and scientific concerns are discussed.

上颌缺损的修复和早期植入内种植体已被广泛报道。上述治疗方式的结合很少在同行评议的期刊上报道。本文介绍上颌缺损患者的临床表现、处理及修复康复。讨论了临床和科学问题。
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引用次数: 0
Cytotoxicity of accelerated white MTA and Malaysian white Portland cement on stem cells from human exfoliated deciduous teeth (SHED): An in vitro study 加速白色MTA和马来西亚白色波特兰水泥对人脱落乳牙(SHED)干细胞细胞毒性的体外研究
Q2 Medicine Pub Date : 2012-12-01 DOI: 10.1016/j.sdj.2012.11.001
Ren Ming Ong, Norhayati Luddin, Hany Mohamed Aly Ahmed, Nor Shamsuria Omar

The aim of this study was to compare the cytotoxicity of accelerated-set white MTA (AWMTA) and accelerated-set Malaysian white PC (AMWPC) on stem cells from human exfoliated deciduous teeth (SHED). The test materials were introduced into paraffin wax moulds after mixing with calcium chloride dihydrate and sterile distilled water. Subsequently, the set cement specimens were sterilized, incubated in a prepared Dulbecco's modified Eagle medium (DMEM) for seven days. The biomarker CD166 was used for characterization of SHED using flow cytometry. The material extracts were diluted at five different concentrations and incubated for 72 h with SHED. The cell viability was evaluated using Dimethylthiazol diphenyltetrazolium bromide (MTT) assay, and the data was analysed using Mann–Whitney test (P<0.05). The results showed that AWMTA revealed significantly greater cell viability at 25 and 12.5 mg/ml concentrations (P<0.05). Concomitantly, AMWPC exhibited greater cell viability at concentrations <12.5 mg/ml and the results were significant at 1.563 mg/ml (P<0.05). Both materials demonstrated moderate cytotoxicity at 25 mg/ml and slight cytotoxicity at 6.25 and 3.125 mg/ml. At 1.563 mg/ml, no cytotoxic activity was merely observed with AMWPC. In conclusion, AMWPC exhibited favourable and comparable cell viability to that of AWMTA, and has the potential to be used as an alternative and less costly material in dental applications.

本研究的目的是比较加速凝结白色MTA (AWMTA)和加速凝结马来西亚白色PC (AMWPC)对人脱落乳牙(SHED)干细胞的细胞毒性。将试验材料与二水合氯化钙和无菌蒸馏水混合后注入石蜡模具。随后,将水泥标本消毒,在制备好的Dulbecco's modified Eagle培养基(DMEM)中孵育7天。生物标志物CD166用于流式细胞术表征SHED。将提取液稀释至5种不同浓度,用SHED孵育72 h。采用二甲基噻唑二苯基溴化四唑(MTT)法测定细胞活力,采用Mann-Whitney检验(P<0.05)对数据进行分析。结果表明,25和12.5 mg/ml浓度的AWMTA显著提高了细胞活力(P<0.05)。同时,AMWPC在12.5 mg/ml浓度下具有较高的细胞活力,在1.563 mg/ml浓度下具有显著性(P<0.05)。两种材料在25 mg/ml时均表现出中度细胞毒性,在6.25和3.125 mg/ml时表现出轻微的细胞毒性。在1.563 mg/ml浓度下,AMWPC无细胞毒活性。总之,与AWMTA相比,AMWPC表现出了良好的细胞活力,并且有潜力作为牙科应用的替代材料和更便宜的材料。
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引用次数: 10
Incidental maxillary sinus findings in patients referred for head and neck CT angiography 上颌窦偶然发现的患者转介头颈部CT血管造影
Q2 Medicine Pub Date : 2012-12-01 DOI: 10.1016/j.sdj.2012.10.001
Christopher G.T. Lim , Manfred Spanger

Background

Maxillary sinus pathology is a common finding on routine CT scans of the head and neck. The purpose of this study was to assess the incidental findings in the maxillary sinus on CT scans in patients who presented for head and neck CT angiography.

Study design

Images of patients referred for head and neck CT angiography were reviewed over a 5-month period. All maxillary sinus incidental findings were recorded and categorised into mucosal thickening, polypoid mucosal thickening, partial and total opacification. The age and gender of the patients and the side of mucosal pathology was also recorded.

Results

A total of 262 CT scans were reviewed (524 maxillary sinuses). Seventy-two patients had pathological changes (27.5%), 44 (16.8%) had mucosal thickening, 20 (8.0%) had polypoid thickening, 6 (2.3%) had partial and another 7 (2.7%) had complete opacification.

Conclusions

There is a high rate of undiagnosed maxillary sinus pathology incidentally found on CT scans. Clinicians reviewing head and neck CT scans such as dentists, general medical practitioners, maxillofacial and ENT surgeons should be vigilant and aware of maxillary sinus disease when interpreting CT scans of the maxilla and patients should be followed up appropriately.

背景上颌窦病变是头颈部常规CT扫描的常见发现。本研究的目的是评估在进行头颈部CT血管造影的患者中,上颌窦CT扫描的偶然发现。研究设计:在5个月的时间里,我们回顾了接受头颈部CT血管造影的患者的图像。记录所有上颌窦偶发病变,并将其分为粘膜增厚、息肉样粘膜增厚、部分和全部混浊。同时记录患者的年龄、性别及粘膜病理情况。结果共检查了262张CT片,其中上颌窦524张。病变72例(27.5%),粘膜增厚44例(16.8%),息肉样增厚20例(8.0%),部分混浊6例(2.3%),完全混浊7例(2.7%)。结论上颌窦病变在CT扫描中偶然发现的比例很高。检查头颈部CT扫描的临床医生,如牙医、全科医生、颌面和耳鼻喉外科医生,在解释上颌CT扫描结果时应警惕并意识到上颌窦疾病,并应适当随访患者。
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引用次数: 14
Prosthodontic Management of an Edentulous Patient With an Acquired Maxillary Defect Reconstructed With an Abdominus Free Flap: A Clinical Report 用腹游离皮瓣重建上颌缺损的无牙患者的修复治疗:临床报告
Q2 Medicine Pub Date : 2011-01-01 DOI: 10.1016/S0377-5291(12)70013-5
Ansgar C Cheng , Alvin G Wee , Sapphire Gan

Functional rehabilitation of fully edentulous maxillary defects is always regarded as a prosthodontic challenge. Surgical augmentation does not always offer value addition in the functional treatment outcome. This article describes the maxillofacial prosthodontic treatment of an edentulous patient who received an abdominus microvascular free flap surgical augmentation of a large acquired maxillary defect.

上颌全无牙缺损的功能康复一直被认为是修复学的一个挑战。手术增强并不总是提供功能性治疗结果的附加价值。这篇文章描述了一个无牙病人接受腹部微血管游离皮瓣手术增加一个大的获得性上颌缺损的修复治疗。
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引用次数: 1
A Land Untouched by Dentistry – Singapore Brings Dental Care to Afghanistan 牙科未被触及的土地-新加坡将牙科护理带到阿富汗
Q2 Medicine Pub Date : 2011-01-01 DOI: 10.1016/S0377-5291(12)70015-9
Peng Hui Tan , Bertrand Chew , Wee Chee Wee , Bernard Tan

In 2007, the Singapore Armed Forces deployed a Dental Project Team (DPT) to the capital city of the Bamiyan Province in Afghanistan. The team set up the province's first modern dental facility. Besides providing primary dental care to the 60,000 population there, the Singaporeans also trained and prepared a team of Afghan dentist and dental assistants. The Afghan dental team took over the dental clinic and continued to provide care when it was time for the DPT to depart for home. Braving challenging security and austere living conditions, the DPT completed its mission successfully.

2007年,新加坡武装部队在阿富汗巴米扬省的首府部署了一支牙科项目小组。这个小组建立了该省第一个现代化的牙科设施。除了为阿富汗6万人口提供初级牙科护理外,新加坡人还培训和培养了一支由阿富汗牙医和牙医助理组成的团队。阿富汗牙科队接管了牙科诊所,并在DPT回国的时候继续提供护理。在严峻的治安条件和艰苦的生活条件下,维和部队圆满完成了任务。
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引用次数: 0
A Rational Approach to Dental Management of Patients on Bisphosphonates 双膦酸盐患者牙科治疗的合理方法
Q2 Medicine Pub Date : 2011-01-01 DOI: 10.1016/S0377-5291(12)70010-X
Juen Bin Lai, Choy Yoke Poon

There has been a lot of focus on osteonecrosis of the jaws associated with the usage of bisphosphonates both in dental and medical literature in recent years. However, the exact pathogenesis of bisphosphonate-related osteonecrosis of the jaws remains unclear. Against the background of emerging evidence of an evolving condition, it is not surprising that there is a lack of robust evidence-based recommendations on dental treatment of patients on bisphosphonates. This paper seeks to provide a rational approach to the dental management of patients on bisphosphonates based on current literature.

近年来,在牙科和医学文献中都有很多关于双膦酸盐的使用与颌骨骨坏死的关注。然而,双膦酸盐相关颌骨骨坏死的确切发病机制尚不清楚。在不断出现的证据表明病情不断发展的背景下,缺乏强有力的基于证据的双磷酸盐患者牙科治疗建议也就不足为奇了。本文旨在提供一个合理的方法,以牙科管理患者的双膦酸盐基于目前的文献。
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引用次数: 1
The Accuracy of Demirjian Method in Dental Age Estimation of Malay Children Demirjian法估算马来儿童牙龄的准确性
Q2 Medicine Pub Date : 2011-01-01 DOI: 10.1016/S0377-5291(12)70012-3
Saifeddin Abu Asab , Siti Noor Fazliah Mohd Noor , Mohd Fadhli Khamis

This study is aimed to evaluate the accuracy of Demirjian method in estimating the chronological age of male and female Kelantanese Malay children between 6 and 16 years of age and to establish a new dental age (DA) curve if the Demirjian method was not found to be accurate. About 905 panoramic radiographs of healthy Malay children between 6 and 16 years of age were collected from the radiographic unit in the Hospital Universiti Sains Malaysia (HUSM) and the orthodontic clinic in Hospital Kota Bharu (HKB). Children who had any disease affecting the dental development, or have agenesis in the lower arch and poor quality radiographic images were excluded. The results showed that Demirjian method overestimated the chronological age (CA) by 1.23 years for boys and 1.20 years for girls and it was less accurate for the Kelantanese Malay children. Thus new standard curve were produced and tested on external samples. Results showed that the mean difference between the chronological age and DA is about 0.17 years for boys and 0.11 years for girls. DA was more advanced in the Kelantanese Malay boys and girls as compared to French-Canadian children in all age groups. It is concluded that the Demirjian method tends to be less accurate in estimating the chronological age in Malay children. The new curve that was produced is more applicable to the Kelantanese Malay children.

本研究旨在评估Demirjian方法在估计6至16岁吉兰丹马来儿童男女实足年龄方面的准确性,并在Demirjian方法不准确的情况下建立新的牙龄(DA)曲线。从马来西亚圣士大学医院(HUSM)的放射科和哥打巴鲁医院(HKB)的正牙诊所收集了大约905张6至16岁健康马来儿童的全景x线片。患有任何影响牙齿发育的疾病,或有下弓发育不全和x线图像质量差的儿童被排除在外。结果表明,Demirjian方法对男孩的实足年龄(CA)高估了1.23岁,对女孩的实足年龄(CA)高估了1.20岁,对吉兰丹马来儿童的实足年龄(CA)估计不准确。从而产生了新的标准曲线,并在外样上进行了测试。结果显示,男孩实足年龄与DA的平均差异约为0.17岁,女孩为0.11岁。与所有年龄组的法裔加拿大儿童相比,发展局在吉兰丹马来男孩和女孩中的表现更为先进。结论是,Demirjian方法在估计马来儿童的实足年龄时往往不太准确。新的曲线更适用于吉兰丹马来儿童。
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引用次数: 31
A Review of the Uses of Fluoride and Outcomes of Dental Caries Control in Singapore 新加坡氟化物的使用和龋齿控制的结果综述
Q2 Medicine Pub Date : 2011-01-01 DOI: 10.1016/S0377-5291(12)70011-1
Gabriel Tse Feng Chong, Patrick Tseng

In 1958, Singapore was the first country in Asia to implement a community water fluoridation program covering 100% of its population. There were no reports of anti-fluoridation activities or calls for referenda then; and at present, there is only mild opposition to water fluoridation. The water was initially fluoridated at 0.7 ppm but was gradually adjusted downwards to 0.6 ppm in January 1992, with a further reduction to 0.5 ppm in January 2008 where it has since remained unchanged. Fluoride varnishes and gels are also available for use by the professional for judicious application in individuals who are at high-risk of dental caries. In addition, fluoridated dentifrices and mouth rinses are also readily available over the counter for home use.

In addition to the use of fluorides, the following factors also contribute to the high level of oral health in Singapore: (i) a highly educated populace; (ii) public health education to increase awareness and literacy is routinely carried out by the Health Promotion Board; (iii) the School Dental Service provides ‘free’ dental care to school children up to 18 years of age; and (iv) primary dental care is also readily accessible by the general public by an extensive network of private and public sector dental clinics.

1958年,新加坡成为亚洲第一个实施社区饮水氟化计划的国家,该计划覆盖了100%的人口。当时没有关于反氟化活动或呼吁全民公决的报告;目前,对水氟化只有轻微的反对。最初,水的氟含量为0.7 ppm,但在1992年1月逐渐下调至0.6 ppm, 2008年1月进一步降至0.5 ppm,此后一直保持不变。氟化物清漆和凝胶也可供专业人士明智地用于龋齿高危人群。此外,含氟牙膏和漱口水也很容易在柜台上买到,供家庭使用。除使用氟化物外,下列因素也有助于新加坡的口腔健康水平高:(i)受过高等教育的民众;㈡卫生促进委员会定期开展公共卫生教育,以提高认识和识字率;(iii)学童牙科服务为18岁以下学童提供“免费”牙科服务;(iv)透过广泛的公营及私营牙科诊所网络,市民亦可轻易获得初级牙科服务。
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引用次数: 8
Maxillofacial Prosthetic Management of an Auricular Defect for a Young Patient With Hemifacial Microsomia: A Clinical Report 颌面假体治疗年轻半面小畸形患者耳廓缺损的临床报告。
Q2 Medicine Pub Date : 2011-01-01 DOI: 10.1016/S0377-5291(12)70014-7
Sze Kheng Lim , Jinn Tong , Ansgar C Cheng

Facial anomalies in hemifacial microsomia patients may have significant psychosocial impact even from a very young age. The management and fabrication of an auricular prosthesis replacement supported by endosseous craniofacial implants for a young patient with Goldenhar-Gorlin Syndrome has been reported. It is beneficial for the defects of a hemifacial microsomia patient to be managed as early as possible, consistent with the patient's ability to manage the prosthesis.

面部畸形的半面小畸形患者可能有显著的社会心理影响,甚至从很小的年龄。本文报道了一例年轻goldenhard - gorlin综合征患者采用骨内颅面种植体支持的耳廓假体置换术。在与患者操作假体的能力相一致的情况下,尽早处理面肌短小症患者的缺陷是有益的。
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引用次数: 2
期刊
Singapore Dental Journal
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