中华病理学杂志最新文献

{"title":"[Primary extramedullary plasmacytoma of the pancreas: report of a case].","authors":"Y Wang, C H Jin, J N Gao, L M Qu","doi":"10.3760/cma.j.cn112151-20250624-00427","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250624-00427","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"190-192"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ectopic liver: a clinicopathological analysis of four cases].","authors":"H F Huang, Q Du, N Wei, M Zhang, Y H Ma","doi":"10.3760/cma.j.cn112151-20250529-00375","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250529-00375","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"181-183"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[HER2 protein expression and gene status in endometrial serous carcinoma].","authors":"S F Wu, P Y Wang, M L Liu, J Wang, Y H Zhang, Y D Wang, H X Zhang, X Zeng","doi":"10.3760/cma.j.cn112151-20250529-00374","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250529-00374","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the characteristics of human epidermal growth factor receptor 2 (HER2) protein expression and gene status in uterine serous carcinoma (USC) patients. <b>Methods:</b> A total of 36 formalin-fixed and paraffin-embedded USC tissue specimens obtained between 2021 and 2022 in Peking Union Medical College Hospital were collected. The expression of HER2 protein and the gene status were detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) respectively, and the results were interpreted according to the 2020 International Society of Gynecological Pathologists recommendations. <b>Results:</b> Among the 36 cases, 11, 8, 12 and 5 cases showed HER2 IHC scores of 0, 1+, 2+, and 3+, respectively. All IHC 3+cases were pure USC. Out of 25 samples with different level of HER2 expression (IHC 1+, IHC 2+and 3+), 16 (64.0%) tumors with heterogeneous stain, which mainly affects the diseases with IHC 2+ (10/12) and IHC 3+ (3/5) lesions. Ten pure USC cases (27.8%, 10/36), involving HER2 IHC 0, IHC 1+, IHC 2+and IHC 3+tumors, harbored HER2 gene amplification by FISH (1, 1, 3 and 5 cases, respectively). All amplified cases exhibited a HER2/CEP17 ratio≥2.0. In addition, the incidences of chromosome 17 (CEP17) polysomy and monosomy were 25.0% (9/36) and 19.4% (7/36), respectively. <b>Conclusions:</b> Most of USC tumors exhibit intratumoral heterogeneity in HER2 IHC stain. Both HER2 IHC positive (3+) and FISH positive occur exclusively in pure USC tumors. HER2 gene amplification can be observed in any HER2 IHC levels.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"173-177"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary pelvic extragonadal choriocarcinoma 16 years after cryptorchidectomy: report of a case].","authors":"Y Han, L Ma, S J Cheng, X Su, F Yang","doi":"10.3760/cma.j.cn112151-20250721-00492","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250721-00492","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in clinicopathological and molecular characteristics of BAP1-mutated clear cell renal cell carcinoma].","authors":"Y Zhan, Y Liu, H M Xu, L T Zhou, C F Wang, X Q Yang","doi":"10.3760/cma.j.cn112151-20250623-00420","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250623-00420","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metastatic Ewing's sarcoma in serous effusions: a clinicopathological analysis of three cases].","authors":"Q J Wang, D W Zhou, J M Zhong, D J Luo, Z R Niu","doi":"10.3760/cma.j.cn112151-20251130-00791","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20251130-00791","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"178-180"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research advances of quantum mechanics in pathology].","authors":"X M Shi, W X Cui, T F Jin","doi":"10.3760/cma.j.cn112151-20250508-00329","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250508-00329","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"204-208"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological characteristics of anaplastic sarcoma of the kidney in children].","authors":"B F Yang, L B Fu, N Zhang, X F Yao, M Zhang, C Jia, X X Guan, J W Wang, L J He","doi":"10.3760/cma.j.cn112151-20250619-00414","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250619-00414","url":null,"abstract":"<p><p><b>Objective:</b> To study the clinical and pathological features of anaplastic sarcoma of the kidney(ASK) in children, and to explore its molecular profiles and differential diagnosis. <b>Methods:</b> Five cases of pediatric ASK diagnosed at Beijing Children's Hospital, Beijing, China from January 2018 to June 2025 were collected. The clinical, histological, and immunohistochemical features were analyzed. Three cases were subjected to TP53 detection using fluorescent in-situ hybridization (FISH), and DICER1 and TP53 detection using PCR amplification and Sanger sequencing. <b>Results:</b> There were 3 males and 2 females. The patients' ages ranged from 1.6 years to 17.7 yeas, with an age of 8.2 (3.8, 12.7). A renal mass was accidentally found in 1 case, and abdominal pain with hematuria was present in 4 cases. Four cases were presented as a unilateral tumor, while one as bilateral tumors. The radiographic features of ASK were cystic and solid masses. The tumors were staged as stage Ⅰ, Ⅴ, Ⅳ, Ⅱ and Ⅱ, respectively. Histologically, all tumors showd both cystic and solid areas, spindle cell components with anaplastic changes and frequent atypical mitotic figures, arranged in a fascicular pattern. Chondroid differentiation and rhabdomyoblasts features were present. Multiloculated cysts showed cystic nephroma-like foci, and subepithelial primitive cells with cambium-like layer appearance. Immunohistochemistry showed that desmin was positive in 3 of the 5 cases, and myogenin and MyoD1 were positive in 2 of the 5 cases. p53 was overexpressed(mutated type) in 2 cases, loss of expression(null type) in 1 case and wild type in 1 case. Ki-67 positive rates were 30%-90%. Three cases with sequencing information harbored DICER-1 mutations(somatic and truncating mutations) and loss of TP53 gene. One patient with bilateral tumors died during follow-up. Another patient had distant metastasis, while the others had no recurrence or metastasis. <b>Conclusions:</b> ASK in children is a rare DICER1-related tumor, with distinct histologic features and biological behavior. The differential diagnosis includes anaplastic Wilms tumor, clear cell sarcoma of the kidney, etc. Integration of clinical manifestations, histology, immunohistochemistry, and molecular studies may be required to render correct diagnosis.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological and molecular features of acquired cystic disease-associated renal cell carcinoma].","authors":"H Z Zhang, Y Zhan, L T Zhou, X Q Yang","doi":"10.3760/cma.j.cn112151-20250724-00504","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250724-00504","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the clinicopathological features, immunophenotype, molecular characteristics and prognosis of acquired cystic disease-associated renal cell carcinoma (ACD-RCC). &lt;b&gt;Methods:&lt;/b&gt; The clinicopathological data of four ACD-RCC cases diagnosed at the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China and one case at the Ningbo Clinical Pathology Diagnostic Center, Ningbo, China between 2018 and 2025 were collected. The clinical, histological, and immunohistochemical characteristics were analyzed. FISH and high-throughput DNA targeted next generation sequencing (NGS) were carried out. Follow-up was conducted with review of relevant literature. &lt;b&gt;Results:&lt;/b&gt; Among the five patients, four were male and one was female, aged 45-71 years. All patients had a history of chronic kidney disease (duration 9-30 years) and received dialysis treatment. Three cases occurred in the right kidney and two in the left kidney. All were single lesions with a maximum diameter of 2.0-15.0 cm. Grossly, the tumors showed a solid-cystic appearance. Histologically, various histological patterns were observed, including cystic (4 cases), tubular (4 cases), papillary (4 cases), solid (2 cases), cribriform (2 cases), and microcystic structures (1 case). Two cases were accompanied by tumor necrosis, and one case was accompanied by sarcomatoid differentiation. The tumor cells had abundant eosinophilic cytoplasm with intracytoplasmic vacuoles, conspicuous nucleoli, and high nuclear grades (World Health Organization/International Society of Urological Pathology nuclear grade 3 or 4). Two cases had focal, clear cytoplasm. Oxalate crystals were present in all tumors. In all cases, the surrounding renal parenchyma was atrophic with multiple cysts. The cysts in three cases were lined by single-or multiple-layered eosinophilic cells, which had abundant cytoplasm and visible nucleoli. Tumor cells in all five cases expressed PAX8, CD10 and P504s. Two cases partially expressed carbonic anhydrase Ⅸ(CAⅨ). Two cases focally expressed CK7, CD117, HMB45, Melan A, TFE3, TFEB, GATA3, 2SC and ALK were negative in all cases. FH, SDHB and SMARCB1 (INI1) proteins were not deficient. TFE3 gene rearrangement was not detected in two cases using FISH with break-apart probes. High-throughput DNA targeted NGS showed that one tumor had a KMT2C mutation, one had KMT2B, TSC1, SETD2 and TP53 mutations, one had an MTOR mutation, one had a TSC2 mutation, and one had an SETD2 mutation. The five cases were followed up for 6-70 months and had no recurrence or metastasis, except one case with local recurrence and retroperitoneal lymph node metastasis four years after the surgery. &lt;b&gt;Conclusions:&lt;/b&gt; ACD-RCC is a rare renal cell carcinoma that occurs in patients with end-stage renal disease and has unique morphological features. It is often associated with favorable prognosis and alterations in genes related to the MTOR/TSC pathway or chromatin modifi","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"133-139"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The application of Mucor specimen as the positive control in the pathological special staining].","authors":"X K Shi, R X Sun, J J Zhang, P He","doi":"10.3760/cma.j.cn112151-20250712-00465","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250712-00465","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"55 2","pages":"184-186"},"PeriodicalIF":0.0,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}