Infectious Diseases: News, Opinions, Training最新文献

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Incidence of mixed cryoglobulinemia and its significance in the development of extrahepatic manifestations in chronic hepatitis C and co-infection chronic hepatitis C/HIV infection 慢性丙型肝炎和慢性丙型肝炎/HIV合并感染中混合冷球蛋白血症的发生率及其在肝外表现发展中的意义

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-2-69-76

N. V. Dunaeva, A. Mazing, S. Lapin, D. Gusev

引用次数: 1

Monitoring the composition of the intestinal microbiome in hematopoietic stem cell transplantation: application in clinical practice 监测造血干细胞移植中肠道微生物组的组成:在临床实践中的应用

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-2-85-90

I. Stoma, M. Uss, N. Milanovich, V. Stoma, T. Gubanova, E. Moduleva

引用次数: 0

A new approach to assessing the immunomodulatory and virus-inhibiting activity of medical preparations 评估药物制剂免疫调节和病毒抑制活性的新方法

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-4-82-90

F. G. Nagieva, E. P. Barkova, A. D. Stroeva, V. N. Laskavy, O. Kharchenko, A. Lisakov, O. Svitich, V. Zverev

引用次数: 0

Clinical experience of Raphamin therapy in outpatients after hospital treatment of COVID-19 pneumonia 新型冠状病毒肺炎住院治疗后门诊患者Raphamin治疗的临床体会

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-3-81-87

A. Mordyk, L. Puzyreva, E. P. Antipova, A. Verbanov

Post-infectious immunosuppression may cause repeated hospitalization after COVID-19 pneumonia. The results of the observational study of the Raphamin use for immunotherapy in the recovery period of COVID-19 pneumonia are presented. Aim: to estimate efficiency of Rafamin usage in patients who have completed the course of inpatient treatment for coronavirus pneumonia. Material and methods. Thirty patients aged 18 to 80 years after hospital treatment of COVID-19 pneumonia were included and randomized into 2 groups (1: 1). All patients received anticoagulants, antioxidants, metabolic drugs. Patients of the 1st group (n=15) were additionally prescribed Raphamin for 5 days. The primary endpoint was the number of repeated hospitalizations due to consequences of COVID-19 and/or new cases of acute respiratory infection for 28 days of follow-up. In addition, dynamic of immune and inflammatory markers (absolute lymphocyte count, C-reactive protein), proportion of patients with immune dysregulation, and duration of symptoms associated with COVID-19 were assessed. Results. The number of hospitalized patients in group 1 was 0 (vs 5 in group 2, p=0.0421). Study therapy reduced the risk of repeated hospitalizations in 1.44 times [relative risk 1.44;95% confidence interval 0.91–2.28];duration of breathlessness decreased from 24.5 to 15.3 days (p=0.0108), and duration of fatigue reduced from 23.6 to 16.8 days (p=0.0452). The proportion of patients with immune markers normalization was 2 times higher than in the comparison group on 14 day of observation. Conclusion. The immunomodulatory therapy may be recommended during the recovery period of COVID-19 pneumonia. © Eco-Vector, 2022.

感染后免疫抑制可能导致COVID-19肺炎后反复住院。本文报道了Raphamin用于COVID-19肺炎恢复期免疫治疗的观察性研究结果。目的:评价冠状病毒肺炎住院治疗结束的患者拉明的使用效率。材料和方法。选取年龄在18 ~ 80岁的新型冠状病毒肺炎住院治疗后患者30例，随机分为2组(1:1)，均给予抗凝、抗氧化剂、代谢药物治疗。第一组患者(n=15)在此基础上加用Raphamin治疗5 d。主要终点是28天随访期间因COVID-19后果和/或急性呼吸道感染新病例而重复住院的次数。此外，还评估了免疫和炎症标志物(绝对淋巴细胞计数、c反应蛋白)的动态、免疫失调患者的比例以及与COVID-19相关的症状持续时间。结果。1组住院人数为0人(2组为5人，p=0.0421)。研究治疗使重复住院的风险降低了1.44次[相对风险1.44;95%可信区间0.91-2.28];呼吸困难持续时间从24.5天减少到15.3天(p=0.0108)，疲劳持续时间从23.6天减少到16.8天(p=0.0452)。观察第14天，免疫标志物恢复正常的患者比例比对照组高2倍。结论。COVID-19肺炎恢复期可推荐免疫调节治疗。©Eco-Vector, 2022。

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引用次数: 0

Approaches to vaccination against coronavirus infection in patients with autoimmune inflammatory rheumatic diseases 自身免疫性炎症性风湿病患者冠状病毒感染疫苗接种的探讨

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-4-118-126

A. A. Tarasova, M. Kostinov, M. Kvasova

The problem of COVID-19 vaccination in patients with autoimmune inflammatory rheumatic diseases is discussed. There is an increased risk of viral infections in these patients. Attending physicians should provide patients with rheumatic diseases with complete information about the risks and benefits of COVID-19 immunoprophylaxis. The use of immunosuppressive drugs, rather than the diseases themselves, can reduce the level of post-vaccination immune response. This requires choosing the optimal time for carrying out COVID-19 vaccination in this group of patients. Fragments of European and American recommendations on vaccination against COVID-19 in patients with rheumatic diseases are given. © 2022 Infectious Diseases: News, Opinions, Training.

引用次数: 0

Some clinical and epidemiological aspects of the course of COVID-19 in people living with HIV 艾滋病毒感染者COVID-19病程的一些临床和流行病学方面

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-1-41-46

N. Dolgova, A. Ryndich, A. Suladze, T. Tverdokhlebova, A. Matuzkova, K. Bolatchiev, L.F. Chernigovec

Objective. To describe the clinical and epidemical characteristics of a new coronavirus disease 2019 (COVID-19) in people living with HIV, for HIV infection implies the development of an immunosuppressive condition that may exacerbate the course of COVID-19. Material and methods. The research is based on retrospective and current epidemiological situation of HIV and SARS-CoV-2 infections in the Southern Russia regions during 2020 and survey of the patients with the co-infections concerning epidemiological, clinical, and laboratory diagnostic information. We collected all data from 15 regional centers for AIDS prevention and control in the Southern and North Caucasus Federal Districts. The survey sample consists of 121 patients. Statistical computation is done with Microsoft Office Excel 2010. Results and discussion. HIV patients of various age and social characteristics are involved in the COVID-19 epidemic process. Within registered HIV and SARS-CoV-2 co-infections all patients have apparent clinical symptoms. Asymptomatic cases are not presented. Mild cases prevail in the sample (48.8%). The frequency of severe and extremely severe was significantly higher in people living with HIV/AIDS on ART more than 2 months against naive PLHIV or using ART up two one month (р<0.05). © 2022 by the authors.

目标。为了描述2019年新型冠状病毒病(COVID-19)在艾滋病毒感染者中的临床和流行特征，因为艾滋病毒感染意味着出现可能加剧COVID-19病程的免疫抑制状况。材料和方法。该研究基于2020年俄罗斯南部地区HIV和SARS-CoV-2感染的回顾性和当前流行病学情况，以及对合并感染患者的流行病学、临床和实验室诊断信息的调查。我们从南高加索和北高加索联邦区的15个艾滋病预防和控制区域中心收集了所有数据。调查样本包括121例患者。统计计算使用Microsoft Office Excel 2010完成。结果和讨论。不同年龄和社会特征的HIV患者参与了COVID-19的流行过程。在登记的HIV和SARS-CoV-2合并感染病例中，所有患者均有明显的临床症状。没有出现无症状的病例。病例以轻症为主(48.8%)。在接受抗逆转录病毒治疗2个月以上或接受抗逆转录病毒治疗2个月以上的艾滋病毒/艾滋病感染者中，严重和极严重的频率显著高于对照组(p <0.05)。©2022作者所有。

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引用次数: 2

The soil sanitary condition in the study areas of Khanty-Mansi Autonomous Okrug – Yugra 汉曼斯自治区-尤格拉研究区土壤卫生状况

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-3-120-124

O. Moskina, N. S. Malysheva, M.V. Kasatkina, L.N. Shafranova, I. I. Kozlova, V. P. Sergiyev, L. Morozova, N. Turbabina

引用次数: 1

Differential diagnosis of measles and infectious mononucleosis 麻疹与传染性单核细胞增多症的鉴别诊断

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-1-64-68

L. Cherenova, E. V. Mirekina, O. Lisina, G.К. Kuandykovna

引用次数: 1

Features of the course and medical and social aspects of a new coronavirus infection in the Republic of Tajikistan 塔吉克斯坦共和国新型冠状病毒感染的病程特点及医学和社会方面

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-1-85-92

J. Abdullozoda, J.Yu. Salomudin, R. Tursunov

The aim - to assess some medical and social aspects of the epidemic process during the first wave of a new coronavirus infectious disease - COVID-19 in the Republic of Tajikistan. Material and methods. The retrospective study was conducted on the basis of an epidemiological analysis of official statistics as part of the epidemiological surveillance of COVID-19 from April 2020 to April 2021. Results and discussion. At the beginning of April 2021, a total of 13 308 cases of COVID-19 were registered, of which the proportion of recovered was 99.3% (13 218 cases), and the number of cases with a fatal outcome was 0.68% (90 cases;the average age of the deceased was 62.3±0.07 years). The peak of infection during the first wave occurred in May and June 2020, when the average daily increase was 97 people. For 2 months of the epidemic in the republic, 44.6% of the total number of patients with COVID-19 became infected, and the number of deaths reached 52 people or 57.7%. Among the patients, men prevailed (65%). The largest number of deaths (76.7%;n=69) was among older people with comorbidities (diabetes mellitus, cardiovascular disease, chronic lung disease, metabolic syndrome, etc.). An analysis of the age structure showed that the main proportion of cases fell on the age group of 40-60 years (42.6%). It was found that a significant proportion of patients with COVID-19 was detected in the Sughd region (33.0%) and Dushanbe (30.1%). Conclusion. The COVID-19 pandemic showed that the national healthcare system of the Republic of Tajikistan was not sufficiently prepared for such a development of the COVID-19 epidemic process. There was an acute shortage of medical and preventive specialists in the republic. Given the current situation in the Republic of Tajikistan, within the framework of epidemiological surveillance, the features of the course of the COVID-19 epidemic process were analyzed, adequate emergency measures were developed and proposed to limit the spread of the virus and reduce the negative impact of COVID-19 on public health. The number of beds has been reasonably expanded, the capacity of the laboratory service has been increased, mass vaccination of the population has been started according to epidemic indications. © 2022 Geotar Media Publishing Group

目的是评估塔吉克斯坦共和国新型冠状病毒传染病- COVID-19第一波流行期间流行过程的一些医学和社会方面。材料和方法。这项回顾性研究是在对官方统计数据进行流行病学分析的基础上进行的，这是2020年4月至2021年4月COVID-19流行病学监测的一部分。结果和讨论。截至2021年4月初，全市共登记新冠肺炎病例13 308例，其中痊愈率为99.3%(13 218例)，死亡病例数为0.68%(90例)，死亡平均年龄为62.3±0.07岁。第一波感染高峰出现在2020年5月和6月，当时平均每天增加97人。在疫情爆发的2个月里，新冠肺炎患者总数的44.6%被感染，死亡人数达到52人，占57.7%。患者中以男性居多(65%)。死亡人数最多的是患有合并症(糖尿病、心血管疾病、慢性肺病、代谢综合征等)的老年人(76.7%，n=69)。年龄结构分析显示，40 ~ 60岁年龄组占病例的主要比例(42.6%)。结果发现，在苏格德地区(33.0%)和杜尚别地区(30.1%)检测到的COVID-19患者占很大比例。结论。COVID-19大流行表明，塔吉克斯坦共和国的国家卫生保健系统没有为COVID-19流行过程的这种发展做好充分准备。共和国严重缺乏医疗和预防专家。针对塔吉克斯坦共和国目前的情况，在流行病学监测框架内，分析了COVID-19流行过程的特点，制定并提出了相应的应急措施，以限制病毒的传播，减少COVID-19对公共卫生的负面影响。合理扩大了病床数量，提高了实验室服务能力，并根据疫情指征开展了人群大规模疫苗接种。©2022 Geotar Media Publishing Group

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引用次数: 1

Features of the COVID-19 in lung tissue damage admitted to hospital 入院肺部组织损伤的新冠肺炎特征

Q4 Social Sciences

Infectious Diseases: News, Opinions, Training

Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-3-28-34

L. Povalyaeva, E. Vdoushkina, E. Borodulina, E. Yakovleva, Zh. P. Vasneva, A. Gerasimov, A. Sukhanova

The COVID-19 pandemic continues to spread despite all the efforts of the medical community. The aim of the study – to identify the features of a new coronavirus infection (COVID-19) with lung tissue damage in men and women receiving inpatient treatment. Material and methods. The method of continuous sampling selected 225 patients admitted to inpatient treatment. The patients were divided in 2 groups: the 1st group – men (n=85), the 2nd group – women (n=140). Statistical processing was carried out using the IBM SPSS Statistics 22.0 program. Results. In a comprehensive study of the features of lung tissue damage by the new coronavirus infection SARS-CoV-2 in men and women was found that women received inpatient treatment more often, after ineffective outpatient treatment, the general serious condition at admission was more typical for women who had a positive result of a PCR-test for the detection of SARS-CoV-2 (p=0.038). In the presence of general clinical manifestations complaints of loss of sense of smell were more often presented by women (p=0.020). According to laboratory studies in the indicators of general clinical and biochemical blood tests, on average men often have higher levels of creatinine (p<0.001), women more often have elevated levels of ESR (p=0.003), erythrocytes (p<0.001), CRP (p=0.042) and decreased hemoglobin (p=0.029). Conclusion. In the first wave of the Wuhan pandemic of the SARS-CoV-2 virus strain women prevailed among patients admitted to inpatient treatment with lung tissue damage after ineffective outpatient treatment (p=0.038). There was a commonality in age and clinical manifestations, of the complaints in women, only loss of sense of smell was more common (p=0.020). The erythrocytosis detected in women, increased ESR and CRP, lower hemoglobin and creatinine levels are not specific for COVID-19. There were no statistically significant differences in the terms of hospitalization and the fatal outcome of the disease between men and women. © Eco-Vector, 2022.

尽管医学界做出了种种努力，但COVID-19大流行仍在继续蔓延。该研究的目的是确定接受住院治疗的男性和女性肺部组织损伤的新型冠状病毒感染(COVID-19)的特征。材料和方法。采用连续抽样的方法选取225例住院患者。患者分为两组:第一组男性85例，第二组女性140例。采用IBM SPSS Statistics 22.0程序进行统计处理。结果。在一项对新型冠状病毒感染SARS-CoV-2对男性和女性肺组织损伤特征的综合研究中发现，女性住院治疗较多，门诊治疗无效后，入院时SARS-CoV-2 pcr检测阳性的女性一般病情更严重(p=0.038)。在有一般临床表现的情况下，女性更常出现嗅觉丧失的主诉(p=0.020)。根据对一般临床和生化血液检查指标的实验室研究，男性的平均肌酐水平往往较高(p<0.001)，女性的ESR水平较高(p=0.003)，红细胞水平较高(p<0.001)， CRP水平较高(p=0.042)，血红蛋白水平较低(p=0.029)。结论。在武汉第一波SARS-CoV-2病毒株大流行中，因门诊治疗无效导致肺组织损伤而住院的患者中女性占主导地位(p=0.038)。在年龄和临床表现上存在共性，在女性主诉中，仅嗅觉丧失更为常见(p=0.020)。在女性中检测到的红细胞增多、ESR和CRP升高、血红蛋白和肌酐水平降低并不是COVID-19的特异性。在住院时间和疾病的致命结果方面，男女之间没有统计学上的显著差异。©Eco-Vector, 2022。

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