M. Mehrafza, A. Raoufi, Elmira Hosseinzadeh, Gholamreza Pourseify, Tahereh Zare Yousefi, T. Shakery, Amirhossein Tamimi
10.30699/jogcr.7.6.518 Background & Objective: Autologous platelet-rich plasma consists of concentrated autologous plasma and several cytokines and growth factors released by activated platelets in injury and inflammation. There is an increasing trend towards the effectiveness of intrauterine PRP infusion in repeated implantation failure patients. The aim of the present study was to describe the impact of intrauterine platelet-rich plasma infusion on the live birth rate in patients with repeated implantation failure. Materials & Methods: The present retrospective uncontrolled study was performed on 96 patients with more than two failed intracytoplasmic sperm injection cycles at Mehr medical institute between 2019 and 2021. Forty-eight hours before embryo transfer, patients received 1 mL lympho-platelet-rich plasma through an intrauterine insemination catheter. Patients were evaluated for pregnancy rate. Endometrial preparation for frozen-thawed embryo transfer was performed. Results: Participants' basal and stimulation characteristics, including gonadotropin dosage, the total number of oocytes, metaphase II oocytes and embryos, endometrial thickness, embryo transfer, quality of transferred embryos, and blastocyst transfer rate were evaluated. A total of 33 and 27 chemical (34.3%) and clinical pregnancies (28.1%) were achieved. Twenty (20.8%) and nineteen (20%) cycles resulted in ongoing pregnancies or live births, respectively. Conclusion: The current study suggests that platelet-rich plasma infusion 48 hours before frozen-thawed embryo transfer may be a good option for repeated implantation failure patients and results in 20% live birth.
{"title":"The Effect of Intrauterine Infusion of Plasma Enriched Platelet on Live Birth Rate in Patients with Implantation Failure: A Retrospective Uncontrolled Study","authors":"M. Mehrafza, A. Raoufi, Elmira Hosseinzadeh, Gholamreza Pourseify, Tahereh Zare Yousefi, T. Shakery, Amirhossein Tamimi","doi":"10.30699/jogcr.7.6.518","DOIUrl":"https://doi.org/10.30699/jogcr.7.6.518","url":null,"abstract":"10.30699/jogcr.7.6.518 Background & Objective: Autologous platelet-rich plasma consists of concentrated autologous plasma and several cytokines and growth factors released by activated platelets in injury and inflammation. There is an increasing trend towards the effectiveness of intrauterine PRP infusion in repeated implantation failure patients. The aim of the present study was to describe the impact of intrauterine platelet-rich plasma infusion on the live birth rate in patients with repeated implantation failure. Materials & Methods: The present retrospective uncontrolled study was performed on 96 patients with more than two failed intracytoplasmic sperm injection cycles at Mehr medical institute between 2019 and 2021. Forty-eight hours before embryo transfer, patients received 1 mL lympho-platelet-rich plasma through an intrauterine insemination catheter. Patients were evaluated for pregnancy rate. Endometrial preparation for frozen-thawed embryo transfer was performed. Results: Participants' basal and stimulation characteristics, including gonadotropin dosage, the total number of oocytes, metaphase II oocytes and embryos, endometrial thickness, embryo transfer, quality of transferred embryos, and blastocyst transfer rate were evaluated. A total of 33 and 27 chemical (34.3%) and clinical pregnancies (28.1%) were achieved. Twenty (20.8%) and nineteen (20%) cycles resulted in ongoing pregnancies or live births, respectively. Conclusion: The current study suggests that platelet-rich plasma infusion 48 hours before frozen-thawed embryo transfer may be a good option for repeated implantation failure patients and results in 20% live birth.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74288692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The O-RADS system has mostly used the evidencebased terms and definitions of the International Ovarian Tumor Analysis (IOTA) model (1, 2, 3). The maximum size of papillary projection/solid component is one of these features that has a nearly high positive likelihood ratio (LR) of malignancy (2.4). This item had a higher positive LR compared to other variables related to the size of the solid part as papillary/lesion ratio and solid/lesion ratio with positive LR of 1.6 and 1.5 respectively (2).
{"title":"Size of Papillary Projection/Solid Component in O-RADS US Risk Stratification and Management System","authors":"B. Moradi, S. Naybandi Atashi, E. Shirali","doi":"10.30699/jogcr.7.6.587","DOIUrl":"https://doi.org/10.30699/jogcr.7.6.587","url":null,"abstract":"The O-RADS system has mostly used the evidencebased terms and definitions of the International Ovarian Tumor Analysis (IOTA) model (1, 2, 3). The maximum size of papillary projection/solid component is one of these features that has a nearly high positive likelihood ratio (LR) of malignancy (2.4). This item had a higher positive LR compared to other variables related to the size of the solid part as papillary/lesion ratio and solid/lesion ratio with positive LR of 1.6 and 1.5 respectively (2).","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84458249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Talayeh, M. Arab, Somayyeh Noei Teymoordash, Noushin Afsharmoghadam, Masoomeh Raoufi, B. Ghavami, M. Asghari
Endometrial stromal sarcoma is a rare condition, constituting nearly 0.2% of all reproductive tract malignancies. The condition mainly affects the peri-menopausal population; however, it can occasionally be found in younger women and adolescents. Here, this is a case of a 20-year-old primiparous female who was referred to us with the main complaint of vaginal bleeding (menometrorrhagia), ongoing for 6 months after delivery. Her sonography report indicated a 5 cm intra-cavitary mass suspicious for myoma or placental polyp. Given the pathology report of low-grade endometrial stromal sarcoma (LGESS) on samples obtained through hysteroscopy and D&C, she underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). Endometrial stromal sarcoma is a rare uterine malignancy of mesenchymal origin that should be considered, even in very young patients.
{"title":"Low-Grade Endometrial Stromal Sarcoma in a Young Woman: A Case Report","authors":"M. Talayeh, M. Arab, Somayyeh Noei Teymoordash, Noushin Afsharmoghadam, Masoomeh Raoufi, B. Ghavami, M. Asghari","doi":"10.30699/jogcr.7.6.569","DOIUrl":"https://doi.org/10.30699/jogcr.7.6.569","url":null,"abstract":"Endometrial stromal sarcoma is a rare condition, constituting nearly 0.2% of all reproductive tract malignancies. The condition mainly affects the peri-menopausal population; however, it can occasionally be found in younger women and adolescents. Here, this is a case of a 20-year-old primiparous female who was referred to us with the main complaint of vaginal bleeding (menometrorrhagia), ongoing for 6 months after delivery. Her sonography report indicated a 5 cm intra-cavitary mass suspicious for myoma or placental polyp. Given the pathology report of low-grade endometrial stromal sarcoma (LGESS) on samples obtained through hysteroscopy and D&C, she underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO). Endometrial stromal sarcoma is a rare uterine malignancy of mesenchymal origin that should be considered, even in very young patients.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81740687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Golshahi, B. Moradi, Forough Jabbari, M. Ahmadi
Fraser syndrome is a rare genetic disorder characterized by multiple structural abnormalities, above all of which are cryptophthalmos and syndactyly. According to reviews of reported cases, diagnostic criteria have been established. Here, we report a case of 18 weeks pregnancy diagnosed with Fraser syndrome presenting with cryptophthalmos, syndactyly, kidney agenesis, and hyper-echogenic lungs during an ultrasound examination. The pregnancy was terminated, and diagnostic features of the syndrome were confirmed afterward. Since the imaging characteristics are unique, it is of value that clinicians become familiar with the appearance of the syndrome to provide families with the opportunity to make timely decisions regarding pregnancy termination and use the prenatal diagnostic tools to have healthy children in subsequent pregnancies.
{"title":"A case of Fraser Syndrome Diagnosed by Ultrasound as a Single Modality; Necessity of Genetic Confirmation?","authors":"F. Golshahi, B. Moradi, Forough Jabbari, M. Ahmadi","doi":"10.30699/jogcr.7.6.574","DOIUrl":"https://doi.org/10.30699/jogcr.7.6.574","url":null,"abstract":"Fraser syndrome is a rare genetic disorder characterized by multiple structural abnormalities, above all of which are cryptophthalmos and syndactyly. According to reviews of reported cases, diagnostic criteria have been established. Here, we report a case of 18 weeks pregnancy diagnosed with Fraser syndrome presenting with cryptophthalmos, syndactyly, kidney agenesis, and hyper-echogenic lungs during an ultrasound examination. The pregnancy was terminated, and diagnostic features of the syndrome were confirmed afterward. Since the imaging characteristics are unique, it is of value that clinicians become familiar with the appearance of the syndrome to provide families with the opportunity to make timely decisions regarding pregnancy termination and use the prenatal diagnostic tools to have healthy children in subsequent pregnancies.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76826258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
10.30699/jogcr.7.5.429 Background & Objective: Endometriosis is associated with the increased risk of coronary heart disease and immune alterations, which may be attributed to the altered lipid profile and decreased serum level of 25–hydroxyl vitamin D (25(OH)D). The present study aimed to evaluate the effect of radical laparoscopic surgery of endometriosis on serum lipid profile and 25(OH)D. Materials & Methods: This cross-sectional study was performed on 47 women aged 15 to 45, with body mass index <30kg/m 2 , who were referred to Shohaday-eTajrish Hospital, from May 2018 until Jan 2020, for surgical treatment of endometriosis and did not have a systemic disease and did not use oral contraceptives and/or other hormonal therapies three months before surgery were enrolled into the study. The serum lipid profile and 25(OH)D levels of patients two months after surgery were compared with presurgical levels. The results were analyzed by using paired t-test. Results: A total of 47 patients completed the study (mean age: 32.8±7.5years). About half had no pregnancies (49.1%). Comparing the serum lipid profile of patients before and two months after surgery showed a significant decrease in triglyceride from 108.4±46.2 to 86.4±51.1 mg/dL ( P =0.001), ], total cholesterol from 172.5±26.5 to 160.0±28.3mg/dl ( P =0.002), and low-density lipoprotein levels from 97±28.3 to 89.8±26.1 mg/dL ( P =.003); however, high-density lipoprotein and 25(OH)D levels did not show a significant difference ( P >0.05). Conclusion: the results of the current study showed that laparoscopic resection of endometriotic lesions resulted in a significant reduction of the unfavorable lipid profile after two months, but not 25(OH)D levels.
{"title":"The Effect of Laparoscopic Radical Surgery for Endometriosis on Serum Levels of Lipid Profile and Vitamin D","authors":"B. Nouri, Mohadese Alemi, A. Baghestani","doi":"10.30699/jogcr.7.5.429","DOIUrl":"https://doi.org/10.30699/jogcr.7.5.429","url":null,"abstract":"10.30699/jogcr.7.5.429 Background & Objective: Endometriosis is associated with the increased risk of coronary heart disease and immune alterations, which may be attributed to the altered lipid profile and decreased serum level of 25–hydroxyl vitamin D (25(OH)D). The present study aimed to evaluate the effect of radical laparoscopic surgery of endometriosis on serum lipid profile and 25(OH)D. Materials & Methods: This cross-sectional study was performed on 47 women aged 15 to 45, with body mass index <30kg/m 2 , who were referred to Shohaday-eTajrish Hospital, from May 2018 until Jan 2020, for surgical treatment of endometriosis and did not have a systemic disease and did not use oral contraceptives and/or other hormonal therapies three months before surgery were enrolled into the study. The serum lipid profile and 25(OH)D levels of patients two months after surgery were compared with presurgical levels. The results were analyzed by using paired t-test. Results: A total of 47 patients completed the study (mean age: 32.8±7.5years). About half had no pregnancies (49.1%). Comparing the serum lipid profile of patients before and two months after surgery showed a significant decrease in triglyceride from 108.4±46.2 to 86.4±51.1 mg/dL ( P =0.001), ], total cholesterol from 172.5±26.5 to 160.0±28.3mg/dl ( P =0.002), and low-density lipoprotein levels from 97±28.3 to 89.8±26.1 mg/dL ( P =.003); however, high-density lipoprotein and 25(OH)D levels did not show a significant difference ( P >0.05). Conclusion: the results of the current study showed that laparoscopic resection of endometriotic lesions resulted in a significant reduction of the unfavorable lipid profile after two months, but not 25(OH)D levels.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73263225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Modares Gilani, A. Mousavi, S. Akhavan, S. Sheikhhasani
Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated. Materials & Methods: The present cross-sectional study examined the QOL of 139 patients with cervical cancer referred to Imam Khomeini hospital, affiliated with the Tehran University of Medical Sciences. For this study, a specific questionnaire of QOL in patients with cervical cancer was used. To determine the predictors of cervical cancer patients, the QOL linear regression model was used. Results: Findings of this study showed that the total score of QOL of patients was 20.97±1.29. Moreover, in the regression model, a significant relationship was observed between the type of treatment and patients' QOL scores and those patients who had neoadjuvant t herapy plus surgery (β= -17.45, P =0.02) and those who received brachytherapy (β= - 14.86 and P =0.09) had a significantly lower QOL score . Conclusion: Overall, the QOL of people with cervical cancer was moderate. the of to the the the and improve the QOL of patients.
背景与目的:宫颈癌是女性最常见的癌症之一。与健康有关的生活质量(QOL)是反映患者健康各个方面的最重要指标之一。本研究对伊朗宫颈癌妇女的生活质量进行了调查。材料与方法:本横断面研究调查了139例转诊至德黑兰医科大学附属伊玛目霍梅尼医院的宫颈癌患者的生活质量。本研究采用宫颈癌患者生活质量问卷。为了确定宫颈癌患者的预测因素，采用生活质量线性回归模型。结果:本组患者生活质量总分为20.97±1.29分。在回归模型中，治疗方式与患者的生活质量评分存在显著相关，新辅助治疗加手术组(β= -17.45, P =0.02)和近距离放疗组(β= - 14.86, P =0.09)的生活质量评分显著低于手术组(β= - 14.86, P =0.09)。结论:宫颈癌患者总体生活质量处于中等水平。提高了患者的生活质量。
{"title":"Investigating the Quality of Life of Patients with Cervical Cancer in Iran","authors":"M. Modares Gilani, A. Mousavi, S. Akhavan, S. Sheikhhasani","doi":"10.30699/jogcr.7.6.530","DOIUrl":"https://doi.org/10.30699/jogcr.7.6.530","url":null,"abstract":"Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated. Materials & Methods: The present cross-sectional study examined the QOL of 139 patients with cervical cancer referred to Imam Khomeini hospital, affiliated with the Tehran University of Medical Sciences. For this study, a specific questionnaire of QOL in patients with cervical cancer was used. To determine the predictors of cervical cancer patients, the QOL linear regression model was used. Results: Findings of this study showed that the total score of QOL of patients was 20.97±1.29. Moreover, in the regression model, a significant relationship was observed between the type of treatment and patients' QOL scores and those patients who had neoadjuvant t herapy plus surgery (β= -17.45, P =0.02) and those who received brachytherapy (β= - 14.86 and P =0.09) had a significantly lower QOL score . Conclusion: Overall, the QOL of people with cervical cancer was moderate. the of to the the the and improve the QOL of patients.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"282 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72702019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Pouryasin, A. Mousavi, Jalil Pakravesh, Delaram Zare Kamel, Shahla Nooriardabili, Shakiba Khodadad, S. Aminimoghaddam, Mehran Ghazimoghadam, Yasaman Farbod, A. Pouryasin
Background & Objective: Persistent infection with some types of Human papillomavirus (HPV), which are high-risk genotypes, can lead the patients toward cervical cancer and, finally, death. Recent studies showed HPV co-infection with non-HPV sexually transmitted infections (non-HPV STIs) could increase the persistency rate of HPV infections. This study aimed to estimate the prevalence of STIs and assess the association of HPV/non-HPV STIs co-infection on cervical cell changes based on cytological findings. Materials & Methods: In this cross-sectional study, in addition to the routine cervical screening, including HPV testing and cytological assessment, non-HPV STI testing was performed on 1065 Iranian women. To assess the HPV and non-HPV STIs, commercial kits were used. Results: 964 (90.5%) women had normal cytology (NILM) results. The overall prevalence of HPV and non-HPV STIs were 39.1% and 68.5%, respectively. HPV-53 (6.5%), -16 (6.1%) and -31 (5.5%) were found as the most prevalent genotypes. Ureaplasma Parvum (UP) (42.7%), Group B Streptococcus (GBS) (23.7%), Candida Species (CS) (23.6%), Ureaplasma Urealyticum (UU) (9.6%), and Mycoplasma Hominis (MH) (7.1%) were found as the most prevalent non-HPV STIs. The co-infection of HPV with GBS played an important role in developing the cervical lesion ( P <0.05). Conclusion: In the present study, the STIs, including HPV, UP, GBS, CS, UU, and MH, were prevalent among the study participant, and it was found that the HPV/GBS co-infection played a significant role in the development of LSIL or worse cytological grades. To clarify this issue, further studies will be conducted.
{"title":"The Prevalence of HPV and non-HPV STIs Among Iranian Women and Assessment of the HPV/non-HPV STIs Co-infection on Cervical Cell Changes","authors":"Mohammad Pouryasin, A. Mousavi, Jalil Pakravesh, Delaram Zare Kamel, Shahla Nooriardabili, Shakiba Khodadad, S. Aminimoghaddam, Mehran Ghazimoghadam, Yasaman Farbod, A. Pouryasin","doi":"10.30699/jogcr.7.5.405","DOIUrl":"https://doi.org/10.30699/jogcr.7.5.405","url":null,"abstract":"Background & Objective: Persistent infection with some types of Human papillomavirus (HPV), which are high-risk genotypes, can lead the patients toward cervical cancer and, finally, death. Recent studies showed HPV co-infection with non-HPV sexually transmitted infections (non-HPV STIs) could increase the persistency rate of HPV infections. This study aimed to estimate the prevalence of STIs and assess the association of HPV/non-HPV STIs co-infection on cervical cell changes based on cytological findings. Materials & Methods: In this cross-sectional study, in addition to the routine cervical screening, including HPV testing and cytological assessment, non-HPV STI testing was performed on 1065 Iranian women. To assess the HPV and non-HPV STIs, commercial kits were used. Results: 964 (90.5%) women had normal cytology (NILM) results. The overall prevalence of HPV and non-HPV STIs were 39.1% and 68.5%, respectively. HPV-53 (6.5%), -16 (6.1%) and -31 (5.5%) were found as the most prevalent genotypes. Ureaplasma Parvum (UP) (42.7%), Group B Streptococcus (GBS) (23.7%), Candida Species (CS) (23.6%), Ureaplasma Urealyticum (UU) (9.6%), and Mycoplasma Hominis (MH) (7.1%) were found as the most prevalent non-HPV STIs. The co-infection of HPV with GBS played an important role in developing the cervical lesion ( P <0.05). Conclusion: In the present study, the STIs, including HPV, UP, GBS, CS, UU, and MH, were prevalent among the study participant, and it was found that the HPV/GBS co-infection played a significant role in the development of LSIL or worse cytological grades. To clarify this issue, further studies will be conducted.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74697231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & Objective: Diabetes Mellitus refers to a group of specific metabolic diseases with a hyperglycemic phenotype. The present study compares pregnancy outcomes and nonstress tests (NST) in insulin-treated diabetic women with healthy pregnant women. Materials & Methods: In this cross-sectional study, pregnancy outcomes and NST results were evaluated in 45 diabetic pregnant women who had received insulin therapy and 90 healthy pregnant women. The NST tracings of all women were applied and evaluated regarding reactive and non-reactive parameters. Data were analyzed using SPSS software version 20 and Fisher's exact test. Results: Our results demonstrated that NST was reactive in 75.6%and was non-reactive in 24.4% of diabetic mothers. There was a significant increase in macrosomia in diabetic mothers with non-reactive NST, while there was no statistical significance between NST results in the two groups. Conclusion: Pregnant women with diabetes are more prone to complications than healthy women. The main complication is the fetal size which leads to difficulties in delivery and increased incidence of cesarean section.
{"title":"The Relationship of Non-stress Test Results and Pregnancy Outcomes in Insulin-treated Diabetic Pregnant Women","authors":"Nooshin Amjadi, Nasrin Mansori, Leili Rezaie Kahkha, Mojtaba Ashrafi, Saeedeh Chalaki, Khadije Rezaie Keikhaie","doi":"10.30699/jogcr.7.5.445","DOIUrl":"https://doi.org/10.30699/jogcr.7.5.445","url":null,"abstract":"Background & Objective: Diabetes Mellitus refers to a group of specific metabolic diseases with a hyperglycemic phenotype. The present study compares pregnancy outcomes and nonstress tests (NST) in insulin-treated diabetic women with healthy pregnant women. Materials & Methods: In this cross-sectional study, pregnancy outcomes and NST results were evaluated in 45 diabetic pregnant women who had received insulin therapy and 90 healthy pregnant women. The NST tracings of all women were applied and evaluated regarding reactive and non-reactive parameters. Data were analyzed using SPSS software version 20 and Fisher's exact test. Results: Our results demonstrated that NST was reactive in 75.6%and was non-reactive in 24.4% of diabetic mothers. There was a significant increase in macrosomia in diabetic mothers with non-reactive NST, while there was no statistical significance between NST results in the two groups. Conclusion: Pregnant women with diabetes are more prone to complications than healthy women. The main complication is the fetal size which leads to difficulties in delivery and increased incidence of cesarean section.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75044917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sedigheh Ghasemian, Somaye Ghasemzadeh, A. Soleimany
Clindamycin, IVIg, and corticosteroids are widely used in medicine. In this study, we represent an unusual case of sinus bradycardia following the administration of these drugs. The patient was a 31-year-old woman who presented a complaint of vaginal bleeding at Shahid Motahhari Hospital, Urmia, Iran. Vaginal examination revealed active bleeding. Laboratory tests reported a positive HCG level. Ultrasonography was performed, and the results showed the presence of retained products of conception. The patient became a candidate for curettage. The initial pulse rate was tachycardia. Laboratory data were reported, platelet count of 16000. Corticosteroids and IVIgs were started. Due to the possibility of infectious abortion, Clindamycin and Gentamicin was started. About 24 hours after curettage and 4 hours after starting clindamycin, the patient felt dizziness. Vital signs were obtained that PR: 38-40. We concluded that clindamycin and IVIg can result in severe bradycardia, even in patients with no previous cardiac history, especially when combined with corticosteroids. As a result, we recommend physicians be more cautious when administrating these medications.
{"title":"Which is Responsible for Bradycardia in Woman Treated for Incomplete Abortion and Thrombocytopenia? Intravenous Immunoglobulins, Methylprednisolone or Clindamycin","authors":"Sedigheh Ghasemian, Somaye Ghasemzadeh, A. Soleimany","doi":"10.30699/jogcr.7.5.466","DOIUrl":"https://doi.org/10.30699/jogcr.7.5.466","url":null,"abstract":"Clindamycin, IVIg, and corticosteroids are widely used in medicine. In this study, we represent an unusual case of sinus bradycardia following the administration of these drugs. The patient was a 31-year-old woman who presented a complaint of vaginal bleeding at Shahid Motahhari Hospital, Urmia, Iran. Vaginal examination revealed active bleeding. Laboratory tests reported a positive HCG level. Ultrasonography was performed, and the results showed the presence of retained products of conception. The patient became a candidate for curettage. The initial pulse rate was tachycardia. Laboratory data were reported, platelet count of 16000. Corticosteroids and IVIgs were started. Due to the possibility of infectious abortion, Clindamycin and Gentamicin was started. About 24 hours after curettage and 4 hours after starting clindamycin, the patient felt dizziness. Vital signs were obtained that PR: 38-40. We concluded that clindamycin and IVIg can result in severe bradycardia, even in patients with no previous cardiac history, especially when combined with corticosteroids. As a result, we recommend physicians be more cautious when administrating these medications.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77933581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & Objective: To see if 900 mg of vaginal isonicotinic acid hydrazide (INH) given 12 hours before insertion of a T380A copper intrauterine device (IUD) was more effective than placebo in increasing insertion ease and reducing insertion discomfort in nulliparous ladies. Materials & Methods: A double-blind, randomized controlled study recruited nulliparous women who wanted to use the Copper IUD for contraception. Women who were WHO-eligible for IUD implantation were recruited and randomly assigned (1:1) to vaginal INH 900 mg or placebo (n=100 in each group), 12 hours before the IUD was placed. The primary endpoint was the ease of insertion for the providers. The number of unsuccessful IUD insertions was also recorded. Results: The groups had similar baseline characteristics. The ease of insertion score in the INH group was lower than in the placebo group (3 (2-5).5 vs. 6 (3-8); P= 0.01), indicating that physicians in the INH group had an easier time inserting the device. The INH group had a reduced mean pain score during the procedure (3.97 ± 0.991 vs. 6.42 ± 0.66; P= 0.001). In the INH group, two incidences of failed IUD insertion occurred (2%) compared to four cases in the control group (4 percent). 0.594 is the p-value. Conclusion: Self-administered INH 900 mg vaginally 12 hours before a copper T380A IUD insertion successfully reduced discomfort during insertion and improved women's satisfaction and ease of insertion as measured by physicians in nulliparous teenagers and young ladies.
{"title":"Clinical Outcome of Self-administered Vaginal Isonicotinic Acid Hydrazide (INH) Before T380A Copper Intrauterine Device Insertion in Adolescent and Young Women: A Double-Blind Randomized Controlled Study","authors":"N. Shady, H. Farouk, H. Sallam","doi":"10.30699/jogcr.7.5.391","DOIUrl":"https://doi.org/10.30699/jogcr.7.5.391","url":null,"abstract":"Background & Objective: To see if 900 mg of vaginal isonicotinic acid hydrazide (INH) given 12 hours before insertion of a T380A copper intrauterine device (IUD) was more effective than placebo in increasing insertion ease and reducing insertion discomfort in nulliparous ladies. Materials & Methods: A double-blind, randomized controlled study recruited nulliparous women who wanted to use the Copper IUD for contraception. Women who were WHO-eligible for IUD implantation were recruited and randomly assigned (1:1) to vaginal INH 900 mg or placebo (n=100 in each group), 12 hours before the IUD was placed. The primary endpoint was the ease of insertion for the providers. The number of unsuccessful IUD insertions was also recorded. Results: The groups had similar baseline characteristics. The ease of insertion score in the INH group was lower than in the placebo group (3 (2-5).5 vs. 6 (3-8); P= 0.01), indicating that physicians in the INH group had an easier time inserting the device. The INH group had a reduced mean pain score during the procedure (3.97 ± 0.991 vs. 6.42 ± 0.66; P= 0.001). In the INH group, two incidences of failed IUD insertion occurred (2%) compared to four cases in the control group (4 percent). 0.594 is the p-value. Conclusion: Self-administered INH 900 mg vaginally 12 hours before a copper T380A IUD insertion successfully reduced discomfort during insertion and improved women's satisfaction and ease of insertion as measured by physicians in nulliparous teenagers and young ladies.","PeriodicalId":36115,"journal":{"name":"Journal of Obstetrics, Gynecology and Cancer Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81181422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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