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The Role of Steroids in Performing Voice 类固醇在嗓音表演中的作用
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-12-02 DOI: 10.1007/s40136-023-00498-7
Paul E. Kwak, Tyler Crosby, R. Branski
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引用次数: 0
Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies 用于候选靶向疗法临床前测试的鼻窦肿瘤实验模型
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-11-27 DOI: 10.1007/s40136-023-00496-9
Helena Codina-Martínez, S. L. Lorenzo-Guerra, V. N. Cabal, R. García-Marín, C. Riobello, L. Suárez-Fernández, B. Vivanco, V. Blanco-Lorenzo, Fernando López, Paula Sánchez-Fernández, Mario A. Hermsen, J. Llorente
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引用次数: 0
Correction to: Bridging the Gap: Musical and Pedagogical Terms for Voice Care Professionals 修正:弥合差距:声音护理专业人员的音乐和教学术语
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-11-10 DOI: 10.1007/s40136-023-00497-8
Kari Ragan
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引用次数: 0
Empty Nose Syndrome as an Iatrogenic Condition from Surgery 空鼻综合征作为外科医源性疾病
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-10-23 DOI: 10.1007/s40136-023-00491-0
Dakshika A. Gunaratne, Andrew V. Thamboo
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引用次数: 0
SWI/SNF-Deficient Sinonasal Carcinomas: Multidisciplinary Research Perspectives 缺乏SWI/ snf的鼻窦癌:多学科研究视角
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-10-21 DOI: 10.1007/s40136-023-00495-w
Serena Danti, Claudio Ricci, Teresa Macchi, Iacopo Dallan, Stefano Berrettini, Alessandro Franchi
Abstract Purpose of Review An emerging subset of dismal sinonasal cancers are those characterized by the loss of a SWItch/Sucrose Non-Fermentable (SWI/SNF) complex unit, such as the SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin (SMARC), which includes two main subtypes: SMARCB1- and SMARCA4-deficient sinonasal carcinomas, ultimately leading to four distinct SWI/SNF-deficient sinonasal tumors. These cancers are rare entities and low treatment responsive malignancies. In fact, they are poorly differentiated and usually detected at a late stage, when invasion of facial and cranial regions had already occurred. Recent Findings From a histological standpoint, SWI/SNF-deficient sinonasal carcinomas belong to the group of sinonasal undifferentiated carcinomas (SNUC); however, their distinctive features disclose a special category for these cancers. The identification of biomarkers and signaling pathways has led to the development of emerging therapies, such as immunotherapy and personalized treatments. Finally, we report preliminary findings on 3D in vitro models of sinonasal cancers, as a multidisciplinary tool that could empower the understanding of SWI/SNF-deficient cancer biology. Summary Here, we review the current knowledge about histological and molecular features of SWI/SNF-deficient sinonasal cancers, with a focus on treatment options and multidisciplinary research perspectives. The possibility of studying SWI/SNF-deficient sinonasal tumors in-depth would be fostered by the establishment of tumor cell lines.
一个新兴的隐性鼻窦癌亚型是那些以SWItch/蔗糖不可发酵(SWI/SNF)复合物单元缺失为特征的癌症亚型,如SWI/SNF相关基质相关肌动蛋白依赖性染色质调节剂(SMARC),其中包括两种主要亚型:SMARCB1-和smarca4缺陷型鼻窦癌,最终导致四种不同的SWI/SNF缺陷型鼻窦肿瘤。这些癌症是罕见的实体和低治疗反应的恶性肿瘤。事实上,它们是低分化的,通常在晚期才发现,此时已经发生了面部和颅骨的侵犯。从组织学角度来看,SWI/ snf缺陷型鼻窦癌属于鼻窦未分化癌(SNUC);然而,它们的独特特征揭示了这些癌症的特殊类别。生物标志物和信号通路的识别导致了新兴疗法的发展,如免疫疗法和个性化治疗。最后,我们报告了鼻窦癌体外3D模型的初步发现,作为一种多学科工具,可以增强对SWI/ snf缺陷癌症生物学的理解。在这里,我们回顾了目前关于SWI/ snf缺陷鼻窦癌的组织学和分子特征,重点介绍了治疗方案和多学科研究前景。通过肿瘤细胞系的建立,为深入研究SWI/ snf缺陷鼻窦肿瘤提供了可能。
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引用次数: 0
Demystifying Vocal Hygiene: Considerations for Professional Voice Users 揭开声音卫生的神秘面纱:专业声音使用者的考虑
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-10-21 DOI: 10.1007/s40136-023-00494-x
Zoe Weston, Sarah L. Schneider
Abstract Purpose of Review Discuss current literature and clinical experience related to vocal hygiene, with special consideration for the professional and performing voice user. Recent Findings Use and non-use-related vocal hygiene factors that may impact professional and performing voice users include hydration, laryngeal irritants, phonotrauma, and voice rest. Key considerations include monitoring both systemic and surface hydration, maintaining awareness of key signs and symptoms of reflux, avoiding phonotraumatic patterns and/or learning to pace voice use when high-impact vocal behaviors are required. Complete voice rest is better suited to treat acute injury and not practical for day-to-day vocal management. Summary Vocal hygiene is one tool within voice therapy that plays a key role in vocal injury prevention and rehabilitation when paired with direct voice therapy. Vocal hygiene education should be individualized, guided by the tenants of meta-therapy and motivational interviewing to increase self-efficacy for change and adherence to recommendations.
综述的目的:讨论目前有关声乐卫生的文献和临床经验,特别考虑到专业和表演的声音使用者。使用和非使用相关的声音卫生因素可能影响专业和表演声音使用者,包括水合作用、喉部刺激、语音创伤和声音休息。关键的考虑因素包括监测全身和表面水合作用,保持对反流的关键体征和症状的认识,避免声部创伤模式和/或在需要高影响的发声行为时学会控制声音的使用。完全的声音休息更适合治疗急性损伤,而不适合日常的声音管理。语音卫生是语音治疗中的一种工具,与直接语音治疗相结合,在语音损伤预防和康复中起着关键作用。声乐卫生教育应该个性化,由元疗法和动机访谈的使用者指导,以提高改变和遵守建议的自我效能。
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引用次数: 0
Central Compartment Atopic Disease: What Are the Defining Clinical Features? 中央室特应性疾病的临床特征是什么?
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-10-11 DOI: 10.1007/s40136-023-00492-z
Emily Miller, Do-Yeon Cho, Bradford A. Woodworth, Jessica W. Grayson
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引用次数: 0
Approach Selection for Planum Sphenoidale and Tuberculum Sellae Meningiomas 蝶平面及鞍结节脑膜瘤入路选择
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-10-07 DOI: 10.1007/s40136-023-00489-8
Ali Tayebi Meybodi, Andrea L. Castillo, James K. Liu
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引用次数: 0
Faculty and Leadership Advancement for People of Color in Otolaryngology 耳鼻喉科有色人种教师和领导进步
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-27 DOI: 10.1007/s40136-023-00490-1
Roberto N. Solis, Tulio A. Valdez
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引用次数: 0
Ethical Issues in Rhinologic Surgery: Balancing Benevolent Care and Advancing Surgical Techniques 鼻外科的伦理问题:平衡仁慈护理和推进外科技术
Q4 OTORHINOLARYNGOLOGY Pub Date : 2023-09-22 DOI: 10.1007/s40136-023-00493-y
Valerie J. Lund, Joanne Rimmer, Andrew Knill
Abstract Purpose of Review To consider ethical aspects of rhinologic surgery including surgical and medical treatment options, new technologies and techniques, informed consent and patient choice. Recent Findings The ethical principles of autonomy, justice, beneficence, non-maleficence and fidelity are fundamental to the practice of medicine as well as to the clinical research that informs new treatment options. Here, they are discussed in the context of treatment of benign rhinologic disease. Summary Surgeons are ethically bound to act in the best interests of the patient, informing and involving them in the clinical decisions and avoiding harm. This requires full and honest discussion with patients about the available treatment options, their potential benefits and risks and cost-effectiveness of newer techniques and technologies.
综述目的探讨鼻外科手术的伦理问题,包括手术和药物治疗方案、新技术和新工艺、知情同意和患者选择。自主、公正、仁慈、无害和忠诚的伦理原则是医学实践和临床研究的基础,为新的治疗方案提供了信息。在这里,他们在治疗良性鼻疾病的背景下进行讨论。从道德上讲,外科医生必须为病人的最大利益服务,告知病人并让他们参与临床决策,避免伤害。这需要与患者就现有的治疗方案、潜在的益处和风险以及新技术的成本效益进行充分和诚实的讨论。
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引用次数: 0
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Current Otorhinolaryngology Reports
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