Pub Date : 2022-04-08DOI: 10.1007/s40136-022-00402-9
M. Wotman, Brandon Gold, M. Takahashi, Lindsey M. Draper, M. Posner
{"title":"Treatment of Recurrent and Metastatic HPV-Associated Squamous Cell Carcinoma","authors":"M. Wotman, Brandon Gold, M. Takahashi, Lindsey M. Draper, M. Posner","doi":"10.1007/s40136-022-00402-9","DOIUrl":"https://doi.org/10.1007/s40136-022-00402-9","url":null,"abstract":"","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"208 - 217"},"PeriodicalIF":0.6,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45007730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.1007/s40136-022-00400-x
Marianella Paz-Lansberg, Dara R. Adams
{"title":"Advances in Surgical Treatment of Rhinitis","authors":"Marianella Paz-Lansberg, Dara R. Adams","doi":"10.1007/s40136-022-00400-x","DOIUrl":"https://doi.org/10.1007/s40136-022-00400-x","url":null,"abstract":"","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"172 - 178"},"PeriodicalIF":0.6,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43108134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-09DOI: 10.1007/s40136-022-00393-7
E. M. Davis
{"title":"Allergy and Immunotherapy During the Pandemic","authors":"E. M. Davis","doi":"10.1007/s40136-022-00393-7","DOIUrl":"https://doi.org/10.1007/s40136-022-00393-7","url":null,"abstract":"","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"167 - 171"},"PeriodicalIF":0.6,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46298958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1007/s40136-021-00389-9
Shin Saito, Hirofumi Shibata, Douglas Adkins, Ravindra Uppaluri
Purpose of review: Herein, we review current evidence and future directions of neoadjuvant immunotherapy in HPV-related head and neck squamous cell carcinoma (HNSCC) by describing published data and ongoing clinical trials.
Recent findings: Although HNSCCs have shown response to immune checkpoint inhibitors in recurrent/metastatic disease, a limited number of patients benefit from this treatment. There is an expanding interest in clarifying the clinical benefit of immunotherapy in earlier stage disease setting including at initial presentation. Neoadjuvant immunotherapy for HPV-related HNSCCs represents a rational approach, as these cancers bear strong viral antigens.
Summary: The majority of patients with HPV-related HNSCC have good prognosis and treatment de-intensification strategies are under evaluation to decrease toxicity and maintain efficacy. On the other hand, a subset of patients with HPV-related HNSCC have a poorer prognosis and additional treatment options are need to improve outcome. Multiple clinical trials are ongoing to evaluate whether neoadjuvant immunotherapy will achieve these goals.
{"title":"Neoadjuvant Immunotherapy Strategies in HPV-Related Head-and-Neck Cancer.","authors":"Shin Saito, Hirofumi Shibata, Douglas Adkins, Ravindra Uppaluri","doi":"10.1007/s40136-021-00389-9","DOIUrl":"https://doi.org/10.1007/s40136-021-00389-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Herein, we review current evidence and future directions of neoadjuvant immunotherapy in HPV-related head and neck squamous cell carcinoma (HNSCC) by describing published data and ongoing clinical trials.</p><p><strong>Recent findings: </strong>Although HNSCCs have shown response to immune checkpoint inhibitors in recurrent/metastatic disease, a limited number of patients benefit from this treatment. There is an expanding interest in clarifying the clinical benefit of immunotherapy in earlier stage disease setting including at initial presentation. Neoadjuvant immunotherapy for HPV-related HNSCCs represents a rational approach, as these cancers bear strong viral antigens.</p><p><strong>Summary: </strong>The majority of patients with HPV-related HNSCC have good prognosis and treatment de-intensification strategies are under evaluation to decrease toxicity and maintain efficacy. On the other hand, a subset of patients with HPV-related HNSCC have a poorer prognosis and additional treatment options are need to improve outcome. Multiple clinical trials are ongoing to evaluate whether neoadjuvant immunotherapy will achieve these goals.</p>","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"108-115"},"PeriodicalIF":0.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385129/pdf/nihms-1776354.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10820844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-24DOI: 10.1007/s40136-022-00392-8
Brett Campbell, Stephanie E. Teng
{"title":"The Laryngeal Manifestations of Allergic Sensitization: a Current Literature Review","authors":"Brett Campbell, Stephanie E. Teng","doi":"10.1007/s40136-022-00392-8","DOIUrl":"https://doi.org/10.1007/s40136-022-00392-8","url":null,"abstract":"","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"195 - 201"},"PeriodicalIF":0.6,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49101273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-23DOI: 10.1007/s40136-022-00391-9
Victoria W. Huang, James G. Naples
{"title":"Eustachian Tube Dysfunction, Eosinophilic Otitis Media, Endolymphatic Hydrops, and the Role of Allergic Rhinitis","authors":"Victoria W. Huang, James G. Naples","doi":"10.1007/s40136-022-00391-9","DOIUrl":"https://doi.org/10.1007/s40136-022-00391-9","url":null,"abstract":"","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"202 - 207"},"PeriodicalIF":0.6,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43013160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-12DOI: 10.1007/s40136-021-00390-2
Maimuna Ahmad, D. Chari, M. McKenna, A. Quesnel
{"title":"Mixed and Sensorineural Hearing Loss in Otosclerosis: Incidence, Pathophysiology, and Treatment","authors":"Maimuna Ahmad, D. Chari, M. McKenna, A. Quesnel","doi":"10.1007/s40136-021-00390-2","DOIUrl":"https://doi.org/10.1007/s40136-021-00390-2","url":null,"abstract":"","PeriodicalId":36165,"journal":{"name":"Current Otorhinolaryngology Reports","volume":"10 1","pages":"8 - 15"},"PeriodicalIF":0.6,"publicationDate":"2022-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45285970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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