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Current Transplantation Reports最新文献

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Past and Present Policy Efforts in Achieving Racial Equity in Kidney Transplantation 过去和现在在实现肾移植种族平等方面的政策努力
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-05-24 DOI: 10.1007/s40472-022-00369-y
Irene K Kim, Paulo N. Martins, M. Pavlakis, N. Eneanya, R. Patzer
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引用次数: 2
Psychosocial Evaluation for Lung Transplantation: an Empirically Informed Update 肺移植的社会心理评估:经验信息更新
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-03-18 DOI: 10.1007/s40472-022-00360-7
L. Christon, Patrick J. Smith
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引用次数: 0
Current Bioethical Issues in Geriatric Organ Transplantation 当前老年器官移植的生物伦理问题
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-03-17 DOI: 10.1007/s40472-022-00364-3
Mariam Fazal, E. Gordon, C. Humbyrd
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引用次数: 2
Pancreas Transplant for Combined Pancreatic Endocrine and Exocrine Insufficiency 胰腺移植治疗胰内分泌、外分泌功能不全
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-03-06 DOI: 10.1007/s40472-022-00361-6
Melissa Chen, T. Dunn
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引用次数: 0
Removal of DSA from KP/Pancreas Allocation 从KP/胰腺分配中去除DSA
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-02-07 DOI: 10.1007/s40472-022-00356-3
Laura A. Rausch, S. Niederhaus, R. Forbes
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引用次数: 1
Multi-Organ Allocation: Medical and Ethical Considerations 多器官分配:医学和伦理考虑
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-01-27 DOI: 10.1007/s40472-022-00354-5
M. Aeder, Kenneth A. Andreoni
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引用次数: 0
Behind the Curtain — the Do’s and Do Not’s of the OPTN and the Final Rule 幕后——OPTN的Do’s和Do’s与最终规则
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-01-27 DOI: 10.1007/s40472-022-00353-6
Yolanda Becker
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引用次数: 1
Heart Transplant Donor Selection: Recent Insights 心脏移植捐献者的选择：最新见解
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-01-19 DOI: 10.1007/s40472-022-00355-4
D. Baran, A. Mohammed, P. Macdonald, H. Copeland
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引用次数: 0
COVID-19 and Solid Organ Transplantation: Role of Anti-SARS-CoV-2 Monoclonal Antibodies. COVID-19 与实体器官移植：抗SARS-CoV-2单克隆抗体的作用
IF 2.4 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-01-01 Epub Date: 2022-01-15 DOI: 10.1007/s40472-022-00357-2
Abhay Dhand, Raymund R Razonable

Purpose of review: Solid organ transplant recipients (SOTRs) are ideal candidates for early treatment or prevention of coronavirus disease 2019 (COVID-19) using anti-SARS-CoV-2 monoclonal antibodies because of multiple underlying medical conditions, chronic immune-suppression, sub-optimal immunogenic response to vaccination, and evolving epidemiological risks. In this article, we review pertinent challenges regarding the management of COVID-19 in SOTRs, describe the role of active and passive immunity in the treatment and prevention of COVID-19, and review real-world data regarding the use of anti-SARS-CoV-2 monoclonal antibodies in SOTRs.

Recent findings: The use of an anti-SARS-CoV-2 monoclonal antibody in high-risk solid organ transplant recipients is associated with a reduction in the risk of hospitalization, need for intensive care, and death related to COVID-19. Overall, the early experiences from a diverse population of solid organ transplant recipients who were treated with anti-spike monoclonal antibodies are encouraging with no reported acute graft injury, severe adverse events, or deaths related to COVID-19.

Summary: Anti-SARS-CoV-2 antibodies are currently authorized for treatment of mild-moderate COVID-19 and post-exposure prophylaxis, including in SOTRs. Potential future uses include pre-exposure prophylaxis in certain high-risk persons and synergistic use along with emerging oral treatment options. Successful timely administration of anti-SARS-CoV-2 monoclonal antibodies requires a multidisciplinary team approach, effective communication between patients and providers, awareness of circulating viral variants, acknowledgement of various biases affecting treatment, and close monitoring for efficacy and tolerability.

审查目的：由于多种基础疾病、慢性免疫抑制、对疫苗接种的免疫原反应不达标以及不断变化的流行病学风险，实体器官移植受者（SOTRs）是使用抗SARS-CoV-2单克隆抗体早期治疗或预防冠状病毒病2019（COVID-19）的理想候选者。在本文中，我们回顾了在 SOTR 中处理 COVID-19 所面临的相关挑战，描述了主动免疫和被动免疫在治疗和预防 COVID-19 中的作用，并回顾了在 SOTR 中使用抗 SARS-CoV-2 单克隆抗体的实际数据：最新研究结果：在高风险的实体器官移植受者中使用抗SARS-CoV-2单克隆抗体可降低与COVID-19相关的住院、重症监护需求和死亡风险。总结：抗SARS-CoV-2抗体目前被授权用于治疗轻度-中度COVID-19和暴露后预防，包括SOTR。未来的潜在用途包括对某些高危人群进行暴露前预防，以及与新出现的口服治疗方案协同使用。成功及时地使用抗 SARS-CoV-2 单克隆抗体需要多学科团队的合作、患者和医疗人员之间的有效沟通、对流行病毒变异的了解、对影响治疗的各种偏见的认识以及对疗效和耐受性的密切监测。
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引用次数: 0
SARS-CoV-2 Vaccines: Safety and Immunogenicity in Solid Organ Transplant Recipients and Strategies for Improving Vaccine Responses. SARS-CoV-2疫苗:实体器官移植受者的安全性和免疫原性以及提高疫苗反应的策略
IF 2.1 Q2 SURGERY
Current Transplantation Reports
Pub Date : 2022-01-01 Epub Date: 2022-01-22 DOI: 10.1007/s40472-022-00359-0
Ayelet Grupper, Helena Katchman

Purpose of review: While solid organ transplant (SOT) recipients are at the highest risk for severe complications and increased mortality from COVID19 disease, their vaccination against SARS-CoV-2 remains challenging due to fear of immune-mediated adverse events and suboptimal immune response. Our current review is aimed to summarize current knowledge about the safety and efficacy of SARS-CoV-2 vaccines, describe factors that are correlated with immune response, and discuss strategies to improve vaccine immunogenicity in SOT recipients.

Recent findings: SARS-CoV-2 vaccines are safe in SOT recipients and not related to rejection or other major adverse events. The immune response to two doses of vaccine is suboptimal and correlated to age and magnitude of immunosuppression. Administration of a third vaccine dose brings to significant amplification of immune response.

Summary: This review strengthens the existing recommendation of vaccination by three doses of vaccine in all SOT recipients and completion of vaccination before transplantation if possible.

综述目的:虽然实体器官移植(SOT)受者患covid - 19疾病严重并发症和死亡率增加的风险最高，但由于担心免疫介导的不良事件和次优免疫反应，他们接种针对SARS-CoV-2的疫苗仍然具有挑战性。本综述旨在总结目前关于SARS-CoV-2疫苗安全性和有效性的知识，描述与免疫反应相关的因素，并讨论提高SOT受体疫苗免疫原性的策略。最近的发现:SARS-CoV-2疫苗在SOT接受者中是安全的，与排斥反应或其他主要不良事件无关。对两剂疫苗的免疫反应是次优的，并与年龄和免疫抑制程度相关。注射第三剂疫苗可显著增强免疫反应。摘要:本综述加强了现有的建议，即所有SOT受者接种三剂疫苗，并在可能的情况下在移植前完成疫苗接种。
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引用次数: 14
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