Pub Date : 2023-08-22DOI: 10.1007/s40472-023-00406-4
M. Ringer, M. Azar, M. Malinis
{"title":"Active and Passive Immunization Approaches in Transplant Recipients","authors":"M. Ringer, M. Azar, M. Malinis","doi":"10.1007/s40472-023-00406-4","DOIUrl":"https://doi.org/10.1007/s40472-023-00406-4","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43462039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-19DOI: 10.1007/s40472-023-00407-3
Chelsea Maguire, A. Tambur
{"title":"Potential Implication of HLA-DQ Heterodimer High-Resolution Typing on Kidney Transplant Outcomes and Equity","authors":"Chelsea Maguire, A. Tambur","doi":"10.1007/s40472-023-00407-3","DOIUrl":"https://doi.org/10.1007/s40472-023-00407-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44912253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-04DOI: 10.1007/s40472-023-00405-5
Christiane Rollenhagen, J. Maltzman
{"title":"The Effects of Aging on Solid Organ Transplantation—Characteristics and Consequences of Immunosenescence","authors":"Christiane Rollenhagen, J. Maltzman","doi":"10.1007/s40472-023-00405-5","DOIUrl":"https://doi.org/10.1007/s40472-023-00405-5","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"135 - 146"},"PeriodicalIF":2.1,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45662224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-03DOI: 10.1007/s40472-023-00404-6
Brian I. Shaw, Moronke Ogundolie, Keenan Caddell, L. McElroy
{"title":"Heart-Kidney Allocation Policy and Proposals Impact Equity of Access for Patients with End-Stage Kidney Disease","authors":"Brian I. Shaw, Moronke Ogundolie, Keenan Caddell, L. McElroy","doi":"10.1007/s40472-023-00404-6","DOIUrl":"https://doi.org/10.1007/s40472-023-00404-6","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"153-158"},"PeriodicalIF":2.1,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41831665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.1007/s40472-023-00399-0
M. Soliman, Amir M Eskander, H. Effat, Tarek Fayad, Tarek Elgohary
{"title":"Adverse Cardiovascular Events in Post-Renal Transplant Patients, a Retrospective Study of Five Hundred Cases Over Twenty-Two Years","authors":"M. Soliman, Amir M Eskander, H. Effat, Tarek Fayad, Tarek Elgohary","doi":"10.1007/s40472-023-00399-0","DOIUrl":"https://doi.org/10.1007/s40472-023-00399-0","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"89 - 99"},"PeriodicalIF":2.1,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47568439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01Epub Date: 2023-03-15DOI: 10.1007/s40472-023-00394-5
Philip Crepeau, Tatiana Fedorova, Lilah F Morris-Wiseman, Aarti Mathur
Purpose of review: Secondary hyperparathyroidism (SHPT) likely contributes to the high prevalence of cognitive decline found among individuals with end-stage kidney disease (ESKD). Our objective is to critically evaluate the recent literature regarding the association between SHPT and cognitive decline and identify potential mechanisms.
Recent findings: Nine studies assessing the relationship between SHPT and cognition have been published in the last two decades, each showing that elevated parathyroid hormone (PTH) levels were associated with cognitive decline. One also found structural changes within the brain related to SHPT. Additionally, two found that SHPT treatment decreases the risk of cognitive decline in ESKD patients.
Summary: SHPT is associated with cognitive impairment. However, the severity of SHPT associated with these changes and the specific cognitive domains affected remain unclear. Future studies are needed to focus on specific cognitive domains, the trajectory of cognitive decline, and optimal treatment strategies including the impact of kidney transplant and tertiary hyperparathyroidism.
{"title":"Secondary Hyperparathyroidism and Cognitive Decline.","authors":"Philip Crepeau, Tatiana Fedorova, Lilah F Morris-Wiseman, Aarti Mathur","doi":"10.1007/s40472-023-00394-5","DOIUrl":"10.1007/s40472-023-00394-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>Secondary hyperparathyroidism (SHPT) likely contributes to the high prevalence of cognitive decline found among individuals with end-stage kidney disease (ESKD). Our objective is to critically evaluate the recent literature regarding the association between SHPT and cognitive decline and identify potential mechanisms.</p><p><strong>Recent findings: </strong>Nine studies assessing the relationship between SHPT and cognition have been published in the last two decades, each showing that elevated parathyroid hormone (PTH) levels were associated with cognitive decline. One also found structural changes within the brain related to SHPT. Additionally, two found that SHPT treatment decreases the risk of cognitive decline in ESKD patients.</p><p><strong>Summary: </strong>SHPT is associated with cognitive impairment. However, the severity of SHPT associated with these changes and the specific cognitive domains affected remain unclear. Future studies are needed to focus on specific cognitive domains, the trajectory of cognitive decline, and optimal treatment strategies including the impact of kidney transplant and tertiary hyperparathyroidism.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"60-68"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44784398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01Epub Date: 2023-03-21DOI: 10.1007/s40472-023-00393-6
Elizabeth C Lorenz, LaTonya J Hickson, Pascale Khairallah, Bijan Najafi, Cassie C Kennedy
Purpose of review: To summarizes the literature on cellular senescence and frailty in solid-organ transplantation and highlight the emerging role of senotherapeutics as a treatment for cellular senescence.
Recent findings: Solid-organ transplant patients are aging. Many factors contribute to aging acceleration in this population, including cellular senescence. Senescent cells accumulate in tissues and secrete proinflammatory and profibrotic proteins which result in tissue damage. Cellular senescence contributes to age-related diseases and frailty. Our understanding of the role cellular senescence plays in transplant-specific complications such as allograft immunogenicity and infections is expanding. Promising treatments, including senolytics, senomorphics, cell-based regenerative therapies, and behavioral interventions, may reduce cellular senescence abundance and frailty in patients with solid-organ transplants.
Summary: Cellular senescence and frailty contribute to adverse outcomes in solid-organ transplantation. Continued pursuit of understanding the role cellular senescence plays in transplantation may lead to improved senotherapeutic approaches and better graft and patient outcomes.
{"title":"Cellular Senescence and Frailty in Transplantation.","authors":"Elizabeth C Lorenz, LaTonya J Hickson, Pascale Khairallah, Bijan Najafi, Cassie C Kennedy","doi":"10.1007/s40472-023-00393-6","DOIUrl":"10.1007/s40472-023-00393-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarizes the literature on cellular senescence and frailty in solid-organ transplantation and highlight the emerging role of senotherapeutics as a treatment for cellular senescence.</p><p><strong>Recent findings: </strong>Solid-organ transplant patients are aging. Many factors contribute to aging acceleration in this population, including cellular senescence. Senescent cells accumulate in tissues and secrete proinflammatory and profibrotic proteins which result in tissue damage. Cellular senescence contributes to age-related diseases and frailty. Our understanding of the role cellular senescence plays in transplant-specific complications such as allograft immunogenicity and infections is expanding. Promising treatments, including senolytics, senomorphics, cell-based regenerative therapies, and behavioral interventions, may reduce cellular senescence abundance and frailty in patients with solid-organ transplants.</p><p><strong>Summary: </strong>Cellular senescence and frailty contribute to adverse outcomes in solid-organ transplantation. Continued pursuit of understanding the role cellular senescence plays in transplantation may lead to improved senotherapeutic approaches and better graft and patient outcomes.</p>","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 2","pages":"51-59"},"PeriodicalIF":2.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10358857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.1007/s40472-023-00398-1
Dawei Zou, Xiaolong Zhang, Wenhao Chen
{"title":"The Functional Adaptability of Hyporesponsive T Cells and Its Impact on Transplant Outcomes","authors":"Dawei Zou, Xiaolong Zhang, Wenhao Chen","doi":"10.1007/s40472-023-00398-1","DOIUrl":"https://doi.org/10.1007/s40472-023-00398-1","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"147 - 152"},"PeriodicalIF":2.1,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49248289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.1007/s40472-023-00396-3
Philip K. Crepeau, T. Fedorova, Lilah F. Morris-Wiseman, A. Mathur
{"title":"Correction to: Secondary Hyperparathyroidism and Cognitive Decline","authors":"Philip K. Crepeau, T. Fedorova, Lilah F. Morris-Wiseman, A. Mathur","doi":"10.1007/s40472-023-00396-3","DOIUrl":"https://doi.org/10.1007/s40472-023-00396-3","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"69"},"PeriodicalIF":2.1,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47273630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-09DOI: 10.1007/s40472-023-00392-7
A. Eccher, P. Antonini, A. Barreca, B. Fabbrizio, U. Boggi, Paola Chiara Rizzo, Ilaria Girolami
{"title":"Digital Slide and Simulation-Based Learning in Pre-Implantation Kidney Biopsies","authors":"A. Eccher, P. Antonini, A. Barreca, B. Fabbrizio, U. Boggi, Paola Chiara Rizzo, Ilaria Girolami","doi":"10.1007/s40472-023-00392-7","DOIUrl":"https://doi.org/10.1007/s40472-023-00392-7","url":null,"abstract":"","PeriodicalId":36387,"journal":{"name":"Current Transplantation Reports","volume":"10 1","pages":"40 - 50"},"PeriodicalIF":2.1,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47304033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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