Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63218
S. Afroze, R. Parvin, K. Nahar, Razia Sultana, S. Rahman, Erfan Ahmed, S. F. Sonia, Azmeri Sultana, N. Ghosh, N. Begum, M. Mannan
Introduction: Neonatal jaundice is one of the most common morbidities observed during the neonatal period. Several risk factors are responsible for this condition. Objective: This study was aimed to determine the possible risk factors and immediate outcome for jaundice in newborns. Methods: This case control study was performed over a period of 18 months (March 2019 -August 2020) in the Special Care Newborn Unit (SCANU) of Dr. M R Khan Shishu Hospital & Institute of Child Health (ICH). Risk factors for jaundice were evaluated by comparing cases with jaundice and controls having no jaundice. Results: A total of 230 neonates with jaundice and 250 neonates having no jaundice were enrolled. Maternal age between 31-40 years, less than 4 antenatal visits, primi, presence of maternal diabetes, babies born via caesarian section, small for gestational age, prematurity and intra-uterine growth restriction were significantly associated with jaundice in neonates (p value < 0.05). Multi-variate analysis revealed, babies with mothers having <4 antenatal visits were found to have 13 times more risk of developing jaundice than their matched controls (p= 0.00, CI= 0.78-14.9). Mean duration of phototherapy was longer for babies having jaundice due to blood group incompatibilities (4.82 ± 1.94). Most of the patients (91%) were discharged to home. Conclusion: Less than four antenatal visit is a significant risk factor for neonates to develop significant jaundice requiring treatment. Babies with blood group incompatibilities tend to require longer duration of phototherapy wherever most of the babies discharged to home with good recovery. DS (Child) H J 2021; 37(2): 109-115
{"title":"Risk Factors and Outcome of Neonatal Hyperbilirubinemia: A Case Control Study in a Tertiary Level Paediatric Hospital","authors":"S. Afroze, R. Parvin, K. Nahar, Razia Sultana, S. Rahman, Erfan Ahmed, S. F. Sonia, Azmeri Sultana, N. Ghosh, N. Begum, M. Mannan","doi":"10.3329/dshj.v37i2.63218","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63218","url":null,"abstract":"Introduction: Neonatal jaundice is one of the most common morbidities observed during the neonatal period. Several risk factors are responsible for this condition. \u0000Objective: This study was aimed to determine the possible risk factors and immediate outcome for jaundice in newborns. \u0000Methods: This case control study was performed over a period of 18 months (March 2019 -August 2020) in the Special Care Newborn Unit (SCANU) of Dr. M R Khan Shishu Hospital & Institute of Child Health (ICH). Risk factors for jaundice were evaluated by comparing cases with jaundice and controls having no jaundice. \u0000Results: A total of 230 neonates with jaundice and 250 neonates having no jaundice were enrolled. Maternal age between 31-40 years, less than 4 antenatal visits, primi, presence of maternal diabetes, babies born via caesarian section, small for gestational age, prematurity and intra-uterine growth restriction were significantly associated with jaundice in neonates (p value < 0.05). Multi-variate analysis revealed, babies with mothers having <4 antenatal visits were found to have 13 times more risk of developing jaundice than their matched controls (p= 0.00, CI= 0.78-14.9). Mean duration of phototherapy was longer for babies having jaundice due to blood group incompatibilities (4.82 ± 1.94). Most of the patients (91%) were discharged to home. \u0000Conclusion: Less than four antenatal visit is a significant risk factor for neonates to develop significant jaundice requiring treatment. Babies with blood group incompatibilities tend to require longer duration of phototherapy wherever most of the babies discharged to home with good recovery. \u0000DS (Child) H J 2021; 37(2): 109-115","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129668388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63158
M. Islam
Abstract not available DS (Child) H J 2021; 37(2): 85-86
摘要不可用DS (Child) [J] 2021;37 (2): 85 - 86
{"title":"Managing Dengue Syndrome in Children: Challenges for Paediatricians","authors":"M. Islam","doi":"10.3329/dshj.v37i2.63158","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63158","url":null,"abstract":"Abstract not available \u0000DS (Child) H J 2021; 37(2): 85-86","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127154814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63159
Md. jahangir Alam
Abstract not available DS (Child) H J 2021; 37(2): 87-92
摘要不可用DS (Child) [J] 2021;37 (2): 87 - 92
{"title":"Impact of COVID-19 on the Symptoms of Asthma in Children and Its Management","authors":"Md. jahangir Alam","doi":"10.3329/dshj.v37i2.63159","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63159","url":null,"abstract":"Abstract not available \u0000DS (Child) H J 2021; 37(2): 87-92","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130028139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63162
R. Akhter, Shubhra Paul, Fannana Ahmed
Background: Recent re-emergence of dengue patient among Bangladeshi children have created a huge burden in the morbidity and mortality of our children. Objectives: This study was designed to document the outcome of dengue patients, admitted in the ICU of Bangladesh Shishu Hospital & Institute (BSH&I). Methods: This retrospective observational study was performed among the children having dengue infection and who were admitted in the PICU of BSH&I from 1st June 2019 to 31st December 2019. All patients who were diagnosed as dengue fever by serological tests (NS1, Dengue IgG & IgM) and those who were admitted in the PICU were included in this study. Total one hundred and twenty-six patients were enrolled. Data were collected from hospital record of the Dengue patients. Results: Mean age of the Dengue patients were 5.91(±3.53) years. Most of the patients suffering from dengue fever were urban dwellers; among them 52.4% were female. Presenting symptoms during admission in the PICU were fever which was present in 119 patients (94.4%), followed by hypotension in 106 (84.1%) patients. Severe dengue (SD) was diagnosed in maximum number of cases (i.e., 62.7%), followed by Dengue fever with warning signs (DFWS) in (20.6%) and Expanded Dengue Syndrome (EDS) in 16.7%. Maximum cases received crystalloid (98.4%), about 51.6% patients received colloid. A good number of patients received blood transfusion (23%), plasma was received in (23%) and albumin was received in (33.3%) cases. Majority of the patients received Oxygen (80.2%); antibiotics were prescribed in 87.3% cases. Fifty-five percent patients received inotropes for the management of shock. The overall outcome revealed 75.4% patients were cured and discharged. Only 21.43% patients died in the PICU despite protocol-based management. Death due to severe dengue was 15(18.9%) out of 79, followed by death due to Dengue Hemorrhagic fever with warning signs which was 8 (30.7%) out of 26 and death in Expanded Dengue syndrome was 4(19.04%) out of 21. Conclusion: This retrospective study found that majority of the Dengue patients admitted in PICU has survived. However the death due to Dengue with warning signs was higher than death in severe Dengue cases. Delayed recognition of warning signs along with delayed referral to PICU may be responsible for such outcome. DS (Child) H J 2021; 37(2): 103-108
{"title":"Outcome of Dengue Patients Admitted in the PICU of Bangladesh Shishu Hospital & Institute","authors":"R. Akhter, Shubhra Paul, Fannana Ahmed","doi":"10.3329/dshj.v37i2.63162","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63162","url":null,"abstract":"Background: Recent re-emergence of dengue patient among Bangladeshi children have created a huge burden in the morbidity and mortality of our children. \u0000Objectives: This study was designed to document the outcome of dengue patients, admitted in the ICU of Bangladesh Shishu Hospital & Institute (BSH&I). \u0000Methods: This retrospective observational study was performed among the children having dengue infection and who were admitted in the PICU of BSH&I from 1st June 2019 to 31st December 2019. All patients who were diagnosed as dengue fever by serological tests (NS1, Dengue IgG & IgM) and those who were admitted in the PICU were included in this study. Total one hundred and twenty-six patients were enrolled. Data were collected from hospital record of the Dengue patients. \u0000Results: Mean age of the Dengue patients were 5.91(±3.53) years. Most of the patients suffering from dengue fever were urban dwellers; among them 52.4% were female. Presenting symptoms during admission in the PICU were fever which was present in 119 patients (94.4%), followed by hypotension in 106 (84.1%) patients. Severe dengue (SD) was diagnosed in maximum number of cases (i.e., 62.7%), followed by Dengue fever with warning signs (DFWS) in (20.6%) and Expanded Dengue Syndrome (EDS) in 16.7%. Maximum cases received crystalloid (98.4%), about 51.6% patients received colloid. A good number of patients received blood transfusion (23%), plasma was received in (23%) and albumin was received in (33.3%) cases. Majority of the patients received Oxygen (80.2%); antibiotics were prescribed in 87.3% cases. Fifty-five percent patients received inotropes for the management of shock. The overall outcome revealed 75.4% patients were cured and discharged. Only 21.43% patients died in the PICU despite protocol-based management. Death due to severe dengue was 15(18.9%) out of 79, followed by death due to Dengue Hemorrhagic fever with warning signs which was 8 (30.7%) out of 26 and death in Expanded Dengue syndrome was 4(19.04%) out of 21. \u0000Conclusion: This retrospective study found that majority of the Dengue patients admitted in PICU has survived. However the death due to Dengue with warning signs was higher than death in severe Dengue cases. Delayed recognition of warning signs along with delayed referral to PICU may be responsible for such outcome. \u0000DS (Child) H J 2021; 37(2): 103-108","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128566868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63160
R. Rashid, A. Karim, F. Islam, S. Mahmud, Sk Serjina Anwar
Background: Pediatric acute liver failure (PALF) is a multisystem disorder that gives rise to severe liver failure within days or weeks and occurs in children without pre-existing chronic liver disease. The etiology of PALF varies with age group and geographical area. Objectives: This study was aimed to evaluate the etiological factors of PALF in Bangladeshi children. Methods: This observational study was conducted at the Department of Paediatric Gastroenterology & Nutrition, Bangabandhu Sheikh Mujib Medical University, Bangladesh, from 2017 to 2020. Twenty-six PALF patients were included, purposively, excluding the acute-on chronic liver failure cases. Demographic data, vaccination history, and other information regarding etiology and complications were recorded. During hospital stay following investigations were performed: Serum bilirubin, liver enzymes, prothrombin time, serum albumin, serum creatinine and electrolytes. Fisher’s exact test determined the association between etiologies of PALF and past histories along with other descriptive statistics using the open-source PSPP software. Results: The average age of the 26 studied patients was 8.6±3.5 years, and 73.1% belonged to 5-12 years of age group. Half of the patients had a history of taking street food or unsafe water. Only six patients had a history of ingestion of herbal medicine. None of the patients had history of vaccination against Hepatitis A. The etiology of PALF patients varied. About 54% of the studied patients had HAV infection, in 23.1% etiology was not determined. About 71.4% of the study patients with HAV infection had a history of taking street food or unsafe water, and this association was statistically significant. Conclusion: This study found that hepatitis A virus infection is the leading cause of paediatric acute liver failure in Bangladesh. Timely preventive measures may help in lowering fatality from liver diseases in children in Bangladesh. DS (Child) H J 2021; 37(2): 93-97
{"title":"Hepatitis A: Leading Cause of Paediatric Acute Liver Failure in Bangladesh","authors":"R. Rashid, A. Karim, F. Islam, S. Mahmud, Sk Serjina Anwar","doi":"10.3329/dshj.v37i2.63160","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63160","url":null,"abstract":"Background: Pediatric acute liver failure (PALF) is a multisystem disorder that gives rise to severe liver failure within days or weeks and occurs in children without pre-existing chronic liver disease. The etiology of PALF varies with age group and geographical area. \u0000Objectives: This study was aimed to evaluate the etiological factors of PALF in Bangladeshi children. \u0000Methods: This observational study was conducted at the Department of Paediatric Gastroenterology & Nutrition, Bangabandhu Sheikh Mujib Medical University, Bangladesh, from 2017 to 2020. Twenty-six PALF patients were included, purposively, excluding the acute-on chronic liver failure cases. Demographic data, vaccination history, and other information regarding etiology and complications were recorded. During hospital stay following investigations were performed: Serum bilirubin, liver enzymes, prothrombin time, serum albumin, serum creatinine and electrolytes. Fisher’s exact test determined the association between etiologies of PALF and past histories along with other descriptive statistics using the open-source PSPP software. \u0000Results: The average age of the 26 studied patients was 8.6±3.5 years, and 73.1% belonged to 5-12 years of age group. Half of the patients had a history of taking street food or unsafe water. Only six patients had a history of ingestion of herbal medicine. None of the patients had history of vaccination against Hepatitis A. The etiology of PALF patients varied. About 54% of the studied patients had HAV infection, in 23.1% etiology was not determined. About 71.4% of the study patients with HAV infection had a history of taking street food or unsafe water, and this association was statistically significant. \u0000Conclusion: This study found that hepatitis A virus infection is the leading cause of paediatric acute liver failure in Bangladesh. Timely preventive measures may help in lowering fatality from liver diseases in children in Bangladesh. \u0000DS (Child) H J 2021; 37(2): 93-97","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122739175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63222
N. Begum, Israt Jahan Chaudhury, N. Bari, S. Afroze
Intrahepatic cholestasis of pregnancy is a condition unique to pregnancy characterized by pruritus and elevated serum bile acids and/or aminotransferase levels. It usually manifests during second or third trimester of pregnancy and improves after delivery. But neonates are at increased risks of still birth, prematurity, respiratory distress syndrome and metabolic problems. Timely identification and appropriate intervention can reduce the adverse neonatal outcomes. DS (Child) H J 2021; 37(2): 135-139
{"title":"Effect of Intrahepatic Cholestasis of Pregnancy (ICP) on Neonatal Outcome","authors":"N. Begum, Israt Jahan Chaudhury, N. Bari, S. Afroze","doi":"10.3329/dshj.v37i2.63222","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63222","url":null,"abstract":"Intrahepatic cholestasis of pregnancy is a condition unique to pregnancy characterized by pruritus and elevated serum bile acids and/or aminotransferase levels. It usually manifests during second or third trimester of pregnancy and improves after delivery. But neonates are at increased risks of still birth, prematurity, respiratory distress syndrome and metabolic problems. Timely identification and appropriate intervention can reduce the adverse neonatal outcomes. \u0000DS (Child) H J 2021; 37(2): 135-139","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124851298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63227
The Editor
Abstract not available DS (Child) H J 2021; 37(2): 147-148
摘要不可用DS (Child) [J] 2021;37 (2): 147 - 148
{"title":"Students Qualified from Bangladesh Institute of Child Health (At present BSH&I) Vol. 37(2)","authors":"The Editor","doi":"10.3329/dshj.v37i2.63227","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63227","url":null,"abstract":"Abstract not available \u0000DS (Child) H J 2021; 37(2): 147-148","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129436305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63220
S. Mahmud, Jahida Gulshan, Madhabi Baidya, R. Rashid, Farhana Tasneem, A. Hasan, T. Farhana, D. Begum, Nafis Fatema Asha, Syed Shafi Ahmed
Background: Upper gastrointestinal endoscopy is an essential, safe and sensitive investigation for diagnosing pediatric gastrointestinal diseases. In resource-limited countries like Bangladesh, the practice of pediatric endoscopy remains rudimentary, lacking in trained pediatric endoscopists and appropriate-sized endoscopes. There is limited study on paediatric upper GI endoscopy in our country. Objectives: The aim of the study was to find out the indications, common endoscopic findings and immediate post procedure complication of UGI endoscopy in children. Methods: This is a retrospective study; the records of all the patients whose age is less than 18 years and who underwent endoscopy in the last 6 years were studied. Results: Among the total of 384 children (age <18 years), the most common indications were recurrent abdominal pain in 133 (34.7%) patients followed by hematemesis±melena in 99 (25.8%), esophageal varices (follow up with eradication) in 67 (17.5%), recurrent vomiting in 31 (8.1%), foreign body, CLD screening, suspected celiac disease, isolated splenomegaly, corrosive injury, and weight loss. The most common abnormal findings were gastritis in 103 (26.9%) children followed by esophageal varices in 73 (19.2%), duodenitis in 26 (6.8%), foreign body, esophagitis, hiatus hernia, esophageal stricture, esophageal ulcer, gastric ulcer, duodenal ulcer etc. Minor adverse events occurred in 7.0% of children. Conclusion: The commonest indication for Pediatric UGI endoscopy was recurrent abdominal pain and the commonest endoscopic feature was gastritis. No significant post procedure complication was noted in the study. DS (Child) H J 2021; 37(2): 123-128
{"title":"Spectrum of Upper GI Endoscopy in Children: A Tertiary Centre Experience from Bangladesh","authors":"S. Mahmud, Jahida Gulshan, Madhabi Baidya, R. Rashid, Farhana Tasneem, A. Hasan, T. Farhana, D. Begum, Nafis Fatema Asha, Syed Shafi Ahmed","doi":"10.3329/dshj.v37i2.63220","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63220","url":null,"abstract":"Background: Upper gastrointestinal endoscopy is an essential, safe and sensitive investigation for diagnosing pediatric gastrointestinal diseases. In resource-limited countries like Bangladesh, the practice of pediatric endoscopy remains rudimentary, lacking in trained pediatric endoscopists and appropriate-sized endoscopes. There is limited study on paediatric upper GI endoscopy in our country. \u0000Objectives: The aim of the study was to find out the indications, common endoscopic findings and immediate post procedure complication of UGI endoscopy in children. \u0000Methods: This is a retrospective study; the records of all the patients whose age is less than 18 years and who underwent endoscopy in the last 6 years were studied. \u0000Results: Among the total of 384 children (age <18 years), the most common indications were recurrent abdominal pain in 133 (34.7%) patients followed by hematemesis±melena in 99 (25.8%), esophageal varices (follow up with eradication) in 67 (17.5%), recurrent vomiting in 31 (8.1%), foreign body, CLD screening, suspected celiac disease, isolated splenomegaly, corrosive injury, and weight loss. The most common abnormal findings were gastritis in 103 (26.9%) children followed by esophageal varices in 73 (19.2%), duodenitis in 26 (6.8%), foreign body, esophagitis, hiatus hernia, esophageal stricture, esophageal ulcer, gastric ulcer, duodenal ulcer etc. Minor adverse events occurred in 7.0% of children. \u0000Conclusion: The commonest indication for Pediatric UGI endoscopy was recurrent abdominal pain and the commonest endoscopic feature was gastritis. No significant post procedure complication was noted in the study. \u0000DS (Child) H J 2021; 37(2): 123-128","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122662999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-11DOI: 10.3329/dshj.v37i2.63161
R. Biswas, Abm Kamrul Hasan
Background: Hypocalcemia accounts for a large number of seizures in infants presented at the emergency department of our hospital. Objective: To evaluate the role of Vitamin D deficiency as the etiology of hypocalcemic seizures in infancy and its relationship with maternal Vitamin D levels. Methods: Cross sectional hospital based study over a period of 35 months from July 2016 to June 2019. Total 60 infants with hypocalcemic seizures were enrolled into the study. Blood samples were taken for serum total calcium, inorganic phosphate, alkaline phosphatase, albumin, 25(OH)D and PTH from the child. Maternal serum 25(OH)D levels were measured as well. Results: The mean age of the studied infants was 3.6 (±1.2) months. All patients had low total calcium (mean 6.5 mg/dl) and most of them had low inorganic phosphate (mean 3.5 mg/dl), while all of them had raised alkaline phosphatase (mean 1093.50 IU/L) and PTH levels (mean104 pg/ml) at presentation. Forty percent of infants were severely deficient and 60% were deficient in vitamin D; none of them were vitamin D sufficient. Among their mothers, none were sufficient, 10% were insufficient, 45% were deficient, and 45% were severe deficient of vitamin D. Neonatal 25(OH)D showed strong negative correlation with their serum PTH levels and strong positive correlations with maternal serum 25(OH)D levels. Conclusion: All infants in our setting presented with hypocalcemic seizures were found due to Vitamin D deficiency and it was mostly related to maternal Vitamin D deficiency. DS (Child) H J 2021; 37(2): 98-102
{"title":"Hypocalcemic Seizures in Infancy and its Relationship with Maternal Vitamin D Deficiency","authors":"R. Biswas, Abm Kamrul Hasan","doi":"10.3329/dshj.v37i2.63161","DOIUrl":"https://doi.org/10.3329/dshj.v37i2.63161","url":null,"abstract":"Background: Hypocalcemia accounts for a large number of seizures in infants presented at the emergency department of our hospital. \u0000Objective: To evaluate the role of Vitamin D deficiency as the etiology of hypocalcemic seizures in infancy and its relationship with maternal Vitamin D levels. \u0000Methods: Cross sectional hospital based study over a period of 35 months from July 2016 to June 2019. Total 60 infants with hypocalcemic seizures were enrolled into the study. Blood samples were taken for serum total calcium, inorganic phosphate, alkaline phosphatase, albumin, 25(OH)D and PTH from the child. Maternal serum 25(OH)D levels were measured as well. \u0000Results: The mean age of the studied infants was 3.6 (±1.2) months. All patients had low total calcium (mean 6.5 mg/dl) and most of them had low inorganic phosphate (mean 3.5 mg/dl), while all of them had raised alkaline phosphatase (mean 1093.50 IU/L) and PTH levels (mean104 pg/ml) at presentation. Forty percent of infants were severely deficient and 60% were deficient in vitamin D; none of them were vitamin D sufficient. Among their mothers, none were sufficient, 10% were insufficient, 45% were deficient, and 45% were severe deficient of vitamin D. Neonatal 25(OH)D showed strong negative correlation with their serum PTH levels and strong positive correlations with maternal serum 25(OH)D levels. \u0000Conclusion: All infants in our setting presented with hypocalcemic seizures were found due to Vitamin D deficiency and it was mostly related to maternal Vitamin D deficiency. \u0000DS (Child) H J 2021; 37(2): 98-102","PeriodicalId":364860,"journal":{"name":"Dhaka Shishu (Children) Hospital Journal","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131207791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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