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National Trends in Rock Climbing Injuries: A 10-Year Epidemiological Analysis of US Emergency Department Data (2014-2023). 攀岩损伤的全国趋势:美国急诊科数据的10年流行病学分析(2014-2023)。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00137
Jacob Q Lin, Jasmeet S Khera, Nikhil Furtado, Augustine Mark Saiz

Background: Rock climbing participation in the United States has grown markedly, yet recent epidemiologic data are limited. This study characterizes national trends, injury patterns, and risk factors for severe injuries among climbers treated in US emergency departments from 2014 to 2023.

Methods: Rock climbing-related injuries were identified in the National Electronic Injury Surveillance System database. Injuries were analyzed by type, body region, mechanism, and demographic group. Weighted logistic regression assessed fracture and hospitalization risk by age and fall height.

Results: From 2014 to 2023, an estimated 47,251 injuries occurred. Fractures (26.8%) were most common, followed by sprains/strains (20.4%), soft tissue (10.2%), and lacerations (8.0%). Lower extremities were most frequently injured (50.6%), followed by upper extremities (26.7%) and torso (14.9%). Falls (58.8%) were the leading mechanism; falls >20 ft carried 52% higher fracture risk (odds ratio = 1.52, [1.41-1.63]). Adults 21 to 45 years accounted for 63.1% of cases. Climbers >45 years had 45% higher fracture odds compared with those 7 to 20 years. Hospitalization occurred in 9% of cases.

Conclusion: Fractures and lower extremity injuries are the most common presentations in US rock climbing Emergency Department visits. Older age and higher fall height were associated with increased severity of the injury.

Level of evidence: Level III. See Instructions for Authors for a complete description of levels of evidence.

背景:攀岩在美国的参与率显著增长,但最近的流行病学数据有限。本研究描述了2014年至2023年在美国急诊室接受治疗的登山者严重受伤的国家趋势、伤害模式和风险因素。方法:在国家电子伤害监测系统数据库中识别攀岩相关伤害。损伤按类型、身体部位、机制和人群进行分析。加权logistic回归评估年龄和坠落高度对骨折和住院风险的影响。结果:从2014年到2023年,估计发生了47251起伤害。最常见的是骨折(26.8%),其次是扭伤/拉伤(20.4%),软组织(10.2%)和撕裂伤(8.0%)。下肢损伤最多(50.6%),其次是上肢(26.7%)和躯干(14.9%)。下跌(58.8%)是主导机制;20英尺以下的瀑布骨折风险高出52%(优势比= 1.52,[1.41-1.63])。21至45岁的成年人占63.1%。45岁以上的登山者骨折几率比7 - 20岁的登山者高45%。9%的病例住院治疗。结论:骨折和下肢损伤是美国攀岩急诊科就诊中最常见的症状。年龄越大,坠落高度越高,损伤的严重程度越高。证据等级:三级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Sufficiency of Isolated Vascularised Fibular Free Flaps for Pediatric Intercalary Lower Limb Reconstruction. 独立带血管腓骨游离皮瓣在小儿肾间段下肢重建中的充分性。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00267
Laura Saenz, Karen W Wong, Kristen M Davidge, Sevan Hopyan

Background: For intercalary defects after resection of pediatric sarcoma, an isolated vascularized free fibular graft (VFFG) offers a living bone option with the potential for durability but is underutilized due to concerns about mechanical sufficiency. By contrast, structural allograft is initially strong but is associated with a high complication profile with or without a composite VFFG (Capanna). Our aim was to compare the complications associated with allograft/VFFG composites to isolated VFFG.

Methods: This is a retrospective comparison of 32 pediatric patients with primary femoral or tibial sarcoma. Reconstructions were categorized into 2 groups: allografts + VFFG (Capanna) (Group 1, n = 9) and "single barrel" isolated VFFG (Group 2, n = 23). Descriptive and inferential statistical analyses were performed.

Results: No significant differences between the 2 groups were observed in age, sex, diagnosis, length of reconstruction, or follow-up (56 months (SD 29) for Group 1 and 53 months (SD 24) for Group 2). Group 1 participants exhibited a higher number of complications including the need for unplanned surgery (mean 2.9) compared with those in Group 2 (mean 1.6, p < 0.01). Disparities in bone healing were notable. At the final follow-up, 46% in Group 1 had achieved full consolidation compared with 96% in Group 2 (p = 0.002). Graft fractures and hardware failures were not different between the groups despite full weight-bearing among all subjects, suggesting mechanical equivalency within the follow-up period. The mean numbers of unplanned surgeries per participant were 4.2 ± SD 4.4 and 2.3 ± SD 2.5 for Groups 1 and 2, respectively (p = 0.149).

Conclusions: Isolated single barrel VFFG reconstructions are structurally sound and had fewer complications and faster union than composite allograft/VFFG composites.

Level of evidence: Retrospective cohort study Level III. See Instructions for Authors for a complete description of levels of evidence.

背景:对于小儿肉瘤切除术后的骨间缺损,孤立的带血管的游离腓骨移植物(VFFG)提供了一种具有耐久性的活骨选择,但由于对机械充足性的担忧而未得到充分利用。相比之下,结构同种异体移植物最初很强壮,但有或没有复合VFFG (Capanna)时,并发症较高。我们的目的是比较同种异体移植物/VFFG复合材料与分离VFFG相关的并发症。方法:回顾性比较32例小儿原发性股骨或胫骨肉瘤。重建分为异体移植+ VFFG (Capanna)组(1组,n = 9)和“单桶”分离VFFG组(2组,n = 23)。进行描述性和推断性统计分析。结果:两组患者在年龄、性别、诊断、重建长度、随访(组1 56个月(SD 29),组2 53个月(SD 24))等方面均无显著差异。与组2(平均1.6,p < 0.01)相比,组1参与者出现了更多的并发症,包括需要进行计划外手术(平均2.9)。骨愈合的差异是显著的。在最后随访时,组1中46%的患者实现了完全巩固,而组2中为96% (p = 0.002)。尽管所有受试者都完全负重,但两组间移植物骨折和硬件故障没有差异,这表明在随访期间力学等效。1组和2组平均每位参与者的计划外手术次数分别为4.2±SD 4.4和2.3±SD 2.5 (p = 0.149)。结论:与同种异体移植物/VFFG复合材料相比,孤立的单管VFFG重建结构良好,并发症少,愈合快。证据水平:回顾性队列研究III级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
A New Procedure-Specific Assessment Tool is Superior to Objective Structured Assessment of Technical Skills in Evaluating Orthopaedic Technical Skills: A Cadaveric Simulation Validation Study. 一种新的程序特异性评估工具优于客观结构化的技术技能评估:一项尸体模拟验证研究。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00199
Mads Emil Jacobsen, Kristoffer Borbjerg Hare, Nanna Sillesen, Marcus Landgren, Katharina Dorothee Engel, Linn Øglænd Johnsen, Lars Konge, Amandus Gustafsson

Background: Competency-based medical education relies on assessment to evaluate performance and guide learning. This study compared the validity evidence and psychometric performance of the Objective Structured Assessment of Technical Skills (OSATS), adapted for distal radius fracture fixation, with a procedure-specific instrument-the Distal Radius Fracture Assessment of Technical Expertise (DRF-RATE)-for assessing technical performance during volar locking plate (VLP) fixation of distal radius fractures (DRFs).

Methods: First-year orthopaedic residents (n = 12) and practicing trauma or hand surgeons (n = 13) performed standardized VLP fixation on a cadaveric DRF model. Anonymous video recordings were independently assessed by 2 orthopaedic trauma surgeons and 2 hand surgeons using either OSATS or DRF-RATE. Validity evidence was gathered in accordance with the Messick contemporary validity framework.

Results: Internal consistency reliability was good-to-excellent for OSATS (α = 0.82-0.98) and DRF-RATE (α = 0.95). Interrater reliability was weaker for OSATS (r = 0.59-0.69) than for DRF-RATE (r = 0.78), though both demonstrated systematic rater bias. OSATS discriminated between novices and experienced surgeons (p = 0.02), whereas DRF-RATE demonstrated even stronger discrimination (p < 0.001). Contrasting-groups analysis revealed higher misclassification rates with OSATS (21%-40%) than DRF-RATE (11%-13%), indicating superior accuracy for the latter.

Conclusions: The DRF-RATE demonstrated stronger and more comprehensive validity evidence than the modified OSATS, with better reliability, higher discrimination and classification accuracy, and overall superior psychometric performance compared with OSATS. Its procedural granularity and structured design address key limitations of OSATS and support detailed, high-quality formative feedback for distal radius fracture fixation.

背景:以能力为本的医学教育依靠评估来评价表现和指导学习。本研究比较了适用于桡骨远端骨折固定的客观结构化技术技能评估(OSATS)与用于评估桡骨远端骨折(drf)掌侧锁定钢板(VLP)固定技术性能的特定程序工具-桡骨远端骨折技术专长评估(DRF-RATE)的效度证据和心理测量学表现。方法:一年级骨科住院医师(n = 12)和创伤或手外科执业医师(n = 13)对尸体DRF模型进行标准化VLP固定。匿名录像由2名骨科创伤外科医生和2名手外科医生使用OSATS或DRF-RATE进行独立评估。根据梅西克当代效度框架收集效度证据。结果:OSATS (α = 0.82 ~ 0.98)和DRF-RATE (α = 0.95)的内部一致性信度为良至优。评估者间信度在OSATS (r = 0.59-0.69)比DRF-RATE (r = 0.78)更弱,尽管两者都表现出系统评估者偏倚。OSATS对新手和有经验的外科医生有歧视(p = 0.02),而DRF-RATE显示出更强的歧视(p < 0.001)。对比组分析显示,OSATS的误分类率(21%-40%)高于DRF-RATE(11%-13%),表明后者的准确率更高。结论:DRF-RATE量表比改进后的OSATS量表具有更强、更全面的效度证据,具有更好的信度、更高的判别和分类准确率,总体心理测量性能优于OSATS量表。其程序性粒度和结构化设计解决了OSATS的主要局限性,并为桡骨远端骨折固定提供了详细、高质量的形成反馈。
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引用次数: 0
Occupational Ionizing Radiation-Induced Skin Injury Among Orthopedic Surgeons: A 5-Year Longitudinal Cohort Study. 骨科医生职业性电离辐射诱发皮肤损伤:一项5年纵向队列研究。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00332
Gentaro Kumagai, Daiki Rokunohe, Eiji Sasaki, Chihiro Sagara, Toru Asari, Takahide Kaneko, Eijiro Akasaka, Yasuyuki Ishibashi

Background: This 5-year longitudinal study evaluated changes in occupational radiation exposure and radiation-induced skin injury among orthopaedic surgeons, focusing on the effects of educational campaigns.

Methods: Orthopaedic surgeons at Hirosaki University were surveyed in 2019 and 2024. Self-reported weekly fluoroscopy ("beam-on") time and dermatologist-graded hand skin findings were compared. Educational campaigns (2020-2023) emphasized As Low As Reasonably Achievable principles and personal protective equipment. We hypothesized that repeated education would improve radiation-safety attitude, reduce self-reported fluoroscopy time, and mitigate dermatologic injury.

Results: The proportion of surgeons cautious about radiation increased from 5.8% to 70.9%. The median weekly self-reported fluoroscopy time decreased from 9.5 to 8.0 minutes (p = 0.045). The prevalence of radiation-induced skin injury declined from 34.9% to 25.6%. Inter-rater reliability was excellent (weighted κ = 0.910). Nonspine surgeon status predicted improvement in skin condition.

Conclusions: During the 5-year period in which repeated radiation-safety education was conducted, surgeons demonstrated improved safety attitudes, decreased self-reported fluoroscopy time, and improved dermatologist-graded skin findings. These observations indicate an association between educational activities, self-reported exposure, and skin findings, but do not establish causality because exposure was self-reported and the study lacked a control group.

Level of evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

背景:这项为期5年的纵向研究评估了骨科医生职业辐射暴露和辐射诱发皮肤损伤的变化,重点关注教育活动的影响。方法:对广崎大学骨科医生于2019年和2024年进行调查。自我报告的每周透视(“光束”)时间和皮肤科医生分级的手部皮肤发现进行比较。教育活动(2020-2023)强调“尽可能低”原则和个人防护装备。我们假设反复教育可以改善辐射安全态度,减少自我报告透视时间,减轻皮肤损伤。结果:对放疗持谨慎态度的医师比例由5.8%上升至70.9%。每周自我报告的透视时间中位数从9.5分钟减少到8.0分钟(p = 0.045)。辐射性皮肤损伤发生率由34.9%下降到25.6%。评分者间信度极好(加权κ = 0.910)。非脊柱外科医师身份预示皮肤状况改善。结论:在反复进行放射安全教育的5年期间,外科医生表现出了更好的安全态度,减少了自我报告的透视时间,改善了皮肤科医生分级的皮肤检查结果。这些观察结果表明教育活动、自我报告暴露和皮肤发现之间存在关联,但由于暴露是自我报告的,并且研究缺乏对照组,因此不能确定因果关系。证据等级:治疗性III级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Opioid Use After Screw Fixation of Slipped Capital Femoral Epiphysis. 股骨骨骺滑动螺钉固定后阿片类药物的应用。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00324
Jonathan R Warren, Stephanie Coupal, Colleen M Moreland, McKenna C Noe, George E Quaye, Lisa Berglund, Caleb W Grote

Background: Slipped capital femoral epiphysis (SCFE) is a common pediatric hip disorder primarily managed with transphyseal screw fixation. Opioid pain medication is often used postoperatively, but there is little evidence to guide prescribing practices. The purpose of this study was to describe opioid utilization and prescribing practices for patients after screw fixation of SCFE.

Methods: This was a prospective observational study of patients with SCFE who underwent transphyseal screw fixation. Patients and guardians were contacted on postoperative days 1, 3, and 5 for data collection. Postdischarge analgesic use, pain severity using a parental proxy, and pain control satisfaction were recorded. Patients who underwent surgical osteotomy or open reduction, patients with cognitive disability, or patients who had other injuries impeding accurate pain assessments were excluded.

Results: Of the 34 patients recruited for the study, 91.2% (31/34) of patients were prescribed opioid medications. Of these 31 patients, 4 were lost to follow-up (87% follow-up). In total, 266 opioid doses were prescribed and 28 were used (p < 0.0001). On average, patients were prescribed 9.85 ± 3.8 opioid doses but used an average of 0.77 ± 1.27 opioid doses (p < 0.0001). Sixty percent of patients did not use any of their prescribed opioid medication, and 90% were satisfied with their pain postoperatively. In addition, 90% of prescribed opioid doses went unused. There was no significant difference in pain control between patients who took opioids and those who did not for each postoperative day. Analysis of opioid use distribution demonstrated that a prescription of 3 doses postoperatively would be sufficient for greater than 95% of all patients.

Conclusions: Overprescription of opioids occurs following screw fixation of SCFE, introducing oversupply into the population. Most patients do excellently with minimal opioid use and have low levels of pain. With adequate nonopioid analgesia counseling and use, outpatient opioid prescriptions following screw fixation of SCFE should be limited. If providers elect to prescribe opioids, we recommend prescribing no more than 3 doses following screw fixation of SCFE.

Level of evidence: Level II. See Instructions for Authors for a complete description of levels of evidence.

背景:股骨头骨骺滑动(SCFE)是一种常见的儿童髋关节疾病,主要采用椎弓根螺钉固定。阿片类止痛药通常在术后使用,但很少有证据指导处方实践。本研究的目的是描述SCFE螺钉固定后患者阿片类药物的使用和处方做法。方法:这是一项前瞻性观察研究,研究对象是经椎弓根钉固定的SCFE患者。于术后第1、3、5天联系患者及监护人收集资料。出院后镇痛药的使用,使用家长代理的疼痛严重程度和疼痛控制满意度记录。接受手术截骨或切开复位的患者、有认知障碍的患者或有其他损伤妨碍准确疼痛评估的患者被排除在外。结果:在纳入研究的34例患者中,91.2%(31/34)的患者使用阿片类药物。31例患者中,4例失访(87%)。总共开了266剂阿片类药物,使用了28剂(p < 0.0001)。患者平均处方9.85±3.8剂阿片类药物,但平均使用0.77±1.27剂阿片类药物(p < 0.0001)。60%的患者没有使用任何处方阿片类药物,90%的患者对术后疼痛感到满意。此外,90%的处方阿片类药物剂量没有使用。术后每天服用阿片类药物的患者和未服用阿片类药物的患者在疼痛控制方面没有显著差异。阿片类药物使用分布分析表明,超过95%的患者术后处方3剂就足够了。结论:SCFE螺钉固定后出现阿片类药物过度处方,导致人群供应过剩。大多数患者在极少使用阿片类药物的情况下表现良好,疼痛程度低。有了充分的非阿片类镇痛咨询和使用,SCFE螺钉固定后门诊阿片类药物处方应受到限制。如果医生选择开阿片类药物,我们建议在螺钉固定SCFE后不超过3剂。证据等级:二级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Intra-articular Hyaluronic Acid for Knee Osteoarthritis: Stabilizing Utilization Trends Amid Conflicting Clinical Practice Guidelines. 关节内透明质酸治疗膝关节骨关节炎:在临床实践指南冲突中稳定使用趋势。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00335
Chris J Lee, Albert H Lee, Wesley Day, Jonathan N Grauer

Background: Evidence has been mixed about the efficacy of intra-articular hyaluronic acid (HA) for knee osteoarthritis. This has led to conflicting clinical practice guidelines (CPGs) over the years. After the American Academy of Orthopaedic Surgeons (AAOS) issued a strong recommendation against HA in 2013, a claims-based study showed rapid decline in use. More recent endorsements from Osteoarthritis Research Society International (OARSI) in 2019 and the Veterans Affairs and Department of Defense (VA-DoD) in 2020 may have altered this trajectory. This study aimed to gauge contemporary utilization of HA knee injections.

Methods: All patients aged 18 years and older diagnosed with knee osteoarthritis were identified from the 2010Q1-2023Q1 PearlDiver database. The percentage of patients receiving intra-articular HA relative to the number of patients diagnosed for knee osteoarthritis was calculated quarterly. Linear regression analyses were segmented by 2 key CPG inflection points: 2013Q3 AAOS' recommendation against HA injections and the 2019Q4 endorsements. Analyses were also stratified by provider specialty. Statistical significance was set at p < 0.05.

Results: A total of 16,581,526 knee OA patients were identified, among which HA knee injections were performed for 1,886,788 (11.4%). For the post-2013 AAOS CPG period (2013Q3-2019Q3), injection rates decreased (-0.10% per quarter; p < 0.001). However, following OARSI/VA-DoD endorsement (2019Q4-2023Q1), the slope leveled to -0.003% per quarter; p = 0.921. Through the study period, utilization declined for both women and men and both younger and older patients (<50 years old and ≥ 50 years old) (p < 0.001 for all). Utilization declined among orthopaedic surgeons, nonoperative musculoskeletal specialists, and primary care physicians, while utilization increased among pain medicine physicians (p < 0.001 for all).

Conclusions: Intra-articular HA injection use decreased after the 2013 CPG from AAOS but has stabilized after more positive 2019 and 2020 CPGs from OARSI/VA-DoD. Notably, practice patterns are diverging patterns across specialties, suggesting variabilities in use.

Level of evidence: Level III. See Instructions for Authors for a complete description of levels of evidence.

背景:关于关节内透明质酸(HA)治疗膝关节骨关节炎的疗效,证据不一。多年来,这导致了相互冲突的临床实践指南(cpg)。在美国骨科医师学会(AAOS)于2013年强烈反对HA之后,一项基于索赔的研究显示,HA的使用率迅速下降。国际骨关节炎研究学会(OARSI)在2019年以及退伍军人事务部和国防部(VA-DoD)在2020年的最新认可可能会改变这一轨迹。本研究旨在评估当代HA膝关节注射的使用情况。方法:所有年龄在18岁及以上诊断为膝骨关节炎的患者均从2010年q1 - 2023q1 PearlDiver数据库中筛选。每季度计算一次接受关节内HA治疗的患者相对于诊断为膝关节骨关节炎的患者数量的百分比。线性回归分析被两个关键的CPG拐点分割:2013年第三季度AAOS反对HA注射的建议和2019年第四季度的认可。分析还按提供者专业进行了分层。p < 0.05为差异有统计学意义。结果:共发现膝关节OA患者16581526例,其中接受HA膝关节注射的患者1886788例(11.4%)。在2013年后的AAOS CPG期间(2013Q3-2019Q3),注射率下降(每季度-0.10%,p < 0.001)。然而,在OARSI/VA-DoD认可(2019Q4-2023Q1)之后,斜率降至每季度-0.003%;P = 0.921。在整个研究期间,女性和男性以及年轻和老年患者的使用均有所下降(结论:在AAOS的2013年CPG后,关节内HA注射的使用减少,但在OARSI/VA-DoD的2019年和2020年CPG更积极后,使用稳定。值得注意的是,实践模式是跨专业的发散模式,表明了使用中的可变性。证据等级:三级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Current Treatment Strategies for Diffuse Tenosynovial Giant Cell Tumor: A Review of the Literature. 目前弥漫性腱鞘巨细胞瘤的治疗策略:文献综述。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00313
Hannah Mosher, Kristen Dean, Gabrielle Meli, Jessyka Desrosiers, Brooke Crawford, H Thomas Temple, Francis J Hornicek, Andrew E Rosenberg, Emily Jonczak, Emanuela Palmerini, Erik J Geiger

Background: Diffuse tenosynovial giant cell tumor (DTGCT) is a locally aggressive benign tumor of the synovium. Patients often initially present with pain, stiffness, and swelling of the affected joint with varying levels of severity. Treatment traditionally involved surgical resection exclusively; however, this could be complicated by high disease recurrence rates. New research has introduced several targeted systemic therapies onto the market changing the treatment paradigm and necessitating a multidisciplinary treatment approach in specialized centers to optimize patient outcomes.

Methods: This review synthesizes the current literature on DTGCT including its pathophysiology, classification, diagnosis, and available treatment options. There is a particular focus on the newer systemic therapies available and how these medications may be used in conjunction with surgery to enhance disease control.

Results: DTGCT most commonly affects young to middle-aged adults, with a slight female predominance, and is most frequently found in the knee. Arthroscopic and even open synovectomy can have disease recurrence rates exceeding 50%. Colony stimulating factor 1 (CSF1) receptor inhibitors have proven effective at symptom palliation and reducing tumor burden in approximately 40% of patients. While these medications improve the quality of life for patients with unresectable disease, they may also be effective in the neoadjuvant setting to downstage surgical approaches and possibly improve disease control in otherwise highly morbid cases.

Conclusions: Surgery alone, the traditional standard for DTGCT, is often insufficient due to high recurrence rates. Systemic therapies can restore function and improve quality of life in patients with advanced disease with rare-but potentially serious-adverse effects. Combining surgical resection with neoadjuvant CSF1R inhibition may provide superior outcomes. Further research is needed to refine the role of systemic agents and develop multidisciplinary protocols. Although initial symptoms often lead patients to community providers, optimal care for patients with DTGCT is best delivered at referral centers with dedicated musculoskeletal oncology programs.

Level of evidence: Level V. See Instructions for Authors for a complete description of levels of evidence.

背景:弥漫性腱鞘巨细胞瘤(DTGCT)是滑膜的一种局部侵袭性良性肿瘤。患者最初通常表现为疼痛、僵硬和受影响关节肿胀,严重程度不一。传统的治疗方法是手术切除;然而,这可能会因疾病的高复发率而变得复杂。新的研究已经向市场引入了几种有针对性的全身疗法,改变了治疗模式,需要在专业中心采用多学科治疗方法来优化患者的治疗效果。方法:本文综述了目前关于DTGCT的相关文献,包括其病理生理、分类、诊断和治疗方案。有一个特别的焦点是新的全身性治疗方法,以及这些药物如何与手术结合使用,以加强疾病控制。结果:DTGCT最常见于青壮年,女性居多,最常见于膝关节。关节镜下甚至开放式滑膜切除术可使疾病复发率超过50%。集落刺激因子1 (CSF1)受体抑制剂已被证明对大约40%的患者的症状缓解和减轻肿瘤负担有效。虽然这些药物改善了不可切除疾病患者的生活质量,但它们也可能在新辅助环境中有效,以减少手术方法,并可能改善其他高度病态病例的疾病控制。结论:单纯手术治疗DTGCT的传统标准由于复发率高,往往是不够的。全身性治疗可以恢复晚期疾病患者的功能并改善其生活质量,并且有罕见但潜在的严重不良反应。联合手术切除与新辅助抑制CSF1R可能提供更好的结果。需要进一步的研究来完善系统药物的作用并制定多学科方案。虽然最初的症状常常导致患者去社区就诊,但DTGCT患者的最佳护理最好是在有专门的肌肉骨骼肿瘤学项目的转诊中心提供。证据等级:v级。参见《作者说明》获得证据等级的完整描述。
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引用次数: 0
Musculoskeletal Manifestations of Perimenopause: A Systematic Review and Meta-Analysis of 93,021 Women. 绝经期肌肉骨骼表现:93021名女性的系统回顾和荟萃分析。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00254
Colin Kruse, Tyler McKechnie, Joshua Dworsky-Fried, Aariz Sardar, Georgia Hacker, Sahaar Rattansi, Evan Fang, Sheila Sprague, Alison K Shea, Mohit Bhandari

Background: The prevalence and characterization of specific types of musculoskeletal (MSK) conditions associated with menopausal transition remains unclear and is often underreported. Our objectives were twofold: (1) to systematically review, and conduct meta-analysis whenever appropriate, to compare the prevalence of MSK symptoms across the different stages of menopause and (2) to characterize the specific MSK conditions associated with transition to menopause.

Methods: We searched Medline, EMBASE, CENTRAL, and PubMed from inception to May 2024. Articles were eligible for inclusion if they included perimenopausal women and reported any primary data on MSK symptoms or pathology. The outcomes we aimed to find included muscle and joint pain, back pain, and the prevalence of various MSK conditions. A pairwise meta-analysis was performed using a DerSimonian-Laird random-effects model for all comparative data, and subgroup analyses were used to explore heterogeneity.

Results: After screening 5,556 relevant records, 37 observational studies across 22 countries enrolling 93,021 women were included in the quantitative analysis. Four in 10 women experienced muscle or joint pain during the premenopausal phase (40% [95% confidence interval {CI}: 32%-49%]). Whereas over half of perimenopausal women (57% [95% CI: 48%-65%]) and postmenopausal women (59% [95% CI: 50%-67%]) experienced muscle or joint pain, representing a 1.35-fold increased risk (risk ratio [RR] 1.35, 95% CI: 1.25-1.46, p < 0.001, I2 = 88.6%; absolute risk difference 130 more per 1,000 [95% CI: 93-171]) and a 1.40-fold increased risk (RR 1.40, 95% CI: 1.28-1.53, p < 0.001, I2 = 95.0%; absolute risk difference 148 more per 1,000 [95% CI: 104-197]) on pairwise comparison with premenopausal women, respectively. Geographic study location nor measurement scale explained the considerable heterogeneity in the pooled analyses. There was underreporting of specific MSK conditions beyond the generic descriptors of muscle and/or joint pain.

Conclusion: Women transitioning to menopause appear to be at increased risk of developing muscle or joint pain. However, as these findings are based on observational studies, specific causes of MSK pain are underreported, and there is significant heterogeneity. Further high-quality research is needed to confirm and clarify this association.

Level of evidence: Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

背景:与绝经过渡相关的特定类型肌肉骨骼(MSK)疾病的患病率和特征仍然不清楚,并且经常被低估。我们的目标有两个:(1)系统回顾,并在适当的时候进行meta分析,比较更年期不同阶段MSK症状的患病率;(2)描述与更年期过渡相关的特定MSK状况。方法:检索Medline、EMBASE、CENTRAL和PubMed,检索时间从成立到2024年5月。如果文章包括围绝经期妇女,并报告了任何有关MSK症状或病理的原始数据,则符合纳入条件。我们旨在发现的结果包括肌肉和关节疼痛、背部疼痛以及各种MSK疾病的患病率。使用DerSimonian-Laird随机效应模型对所有比较数据进行两两荟萃分析,并使用亚组分析来探索异质性。结果:在筛选了5556项相关记录后,来自22个国家的37项观察性研究纳入了93021名女性。10名女性中有4名在绝经前经历过肌肉或关节疼痛(40%[95%可信区间{CI}: 32%-49%])。然而,超过一半的围绝经期妇女(57% [95% CI: 48%-65%])和绝经后妇女(59% [95% CI: 50%-67%])经历肌肉或关节疼痛,风险增加1.35倍(风险比[RR] 1.35, 95% CI: 1.25-1.46, p < 0.001, I2 = 88.6%;绝对风险差[95% CI: 93-171] 130 / 1000)和1.40倍的风险增加(RR 1.40, 95% CI: 1.28-1.53, p < 0.001, I2 = 95.0%;绝对风险差148 / 1000 [95% CI: 104-197]),分别与绝经前妇女两两比较。地理研究地点和测量尺度解释了合并分析中相当大的异质性。除了肌肉和/或关节疼痛的通用描述外,还有对特定MSK条件的少报。结论:过渡到更年期的女性出现肌肉或关节疼痛的风险增加。然而,由于这些发现是基于观察性研究,MSK疼痛的具体原因被低估了,并且存在显著的异质性。需要进一步的高质量研究来证实和澄清这种关联。证据等级:诊断级IV。参见《作者指南》获得证据等级的完整描述。
{"title":"Musculoskeletal Manifestations of Perimenopause: A Systematic Review and Meta-Analysis of 93,021 Women.","authors":"Colin Kruse, Tyler McKechnie, Joshua Dworsky-Fried, Aariz Sardar, Georgia Hacker, Sahaar Rattansi, Evan Fang, Sheila Sprague, Alison K Shea, Mohit Bhandari","doi":"10.2106/JBJS.OA.25.00254","DOIUrl":"10.2106/JBJS.OA.25.00254","url":null,"abstract":"<p><strong>Background: </strong>The prevalence and characterization of specific types of musculoskeletal (MSK) conditions associated with menopausal transition remains unclear and is often underreported. Our objectives were twofold: (1) to systematically review, and conduct meta-analysis whenever appropriate, to compare the prevalence of MSK symptoms across the different stages of menopause and (2) to characterize the specific MSK conditions associated with transition to menopause.</p><p><strong>Methods: </strong>We searched Medline, EMBASE, CENTRAL, and PubMed from inception to May 2024. Articles were eligible for inclusion if they included perimenopausal women and reported any primary data on MSK symptoms or pathology. The outcomes we aimed to find included muscle and joint pain, back pain, and the prevalence of various MSK conditions. A pairwise meta-analysis was performed using a DerSimonian-Laird random-effects model for all comparative data, and subgroup analyses were used to explore heterogeneity.</p><p><strong>Results: </strong>After screening 5,556 relevant records, 37 observational studies across 22 countries enrolling 93,021 women were included in the quantitative analysis. Four in 10 women experienced muscle or joint pain during the premenopausal phase (40% [95% confidence interval {CI}: 32%-49%]). Whereas over half of perimenopausal women (57% [95% CI: 48%-65%]) and postmenopausal women (59% [95% CI: 50%-67%]) experienced muscle or joint pain, representing a 1.35-fold increased risk (risk ratio [RR] 1.35, 95% CI: 1.25-1.46, p < 0.001, I<sup>2</sup> = 88.6%; absolute risk difference 130 more per 1,000 [95% CI: 93-171]) and a 1.40-fold increased risk (RR 1.40, 95% CI: 1.28-1.53, p < 0.001, I<sup>2</sup> = 95.0%; absolute risk difference 148 more per 1,000 [95% CI: 104-197]) on pairwise comparison with premenopausal women, respectively. Geographic study location nor measurement scale explained the considerable heterogeneity in the pooled analyses. There was underreporting of specific MSK conditions beyond the generic descriptors of muscle and/or joint pain.</p><p><strong>Conclusion: </strong>Women transitioning to menopause appear to be at increased risk of developing muscle or joint pain. However, as these findings are based on observational studies, specific causes of MSK pain are underreported, and there is significant heterogeneity. Further high-quality research is needed to confirm and clarify this association.</p><p><strong>Level of evidence: </strong>Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":36492,"journal":{"name":"JBJS Open Access","volume":"11 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12784006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Vertebral Body Tethering in Adolescent Idiopathic Scoliosis: A Prospective, Multicenter Study. 青少年特发性脊柱侧凸椎体栓系治疗的结果:一项前瞻性、多中心研究。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00309
Hans K Nugraha, Lawrence L Haber, Daniel G Hoernschemeyer, Patrick J Cahill, Amer F Samdani, Firoz Miyanji, Peter O Newton, A Noelle Larson

Background: Vertebral body tethering (VBT) for adolescent idiopathic scoliosis (AIS) is an alternative to posterior fusion. There are limited prospective, multicenter data available on VBT following US Food and Drug Administration approval. We hypothesize that curve correction on first postoperative standing (first erect, FE) imaging is associated with higher rates of successful correction at final follow-up.

Methods: All qualifying patients with AIS who underwent thoracic and lumbar VBT between 2019 and 2022 were prospectively enrolled from 9 institutions. Radiographic and clinical data were compared preoperatively, at FE, and at final follow-up with minimum of 2 years. Success was defined as major curve magnitude of ≤35° at final follow-up and no fusion surgery.

Results: One hundred twenty-seven patients were enrolled (79.5% female), with mean follow-up 2.4 years. Mean age at surgery was 12.9 ± 1.4 years, most had bone age of Sanders 4 or lower (93/112, 83.0%). In average, 7.6 ± 1.7 levels were tethered. Mean preoperative major curve magnitude was 50 ± 8°, with mean initial correction at FE of 29 ± 8° (% correction, 39 ± 18%). At final follow-up, mean curve magnitude was maintained at 26 ± 11° (% correction, 45 ± 23%) despite 29% of tether breakage. Patients who had mean FE curve magnitude of ≤35° were 88% successful compared with only 60% in those with >35° on FE (p = 0.0021). Patients showed stable sagittal alignment across all timepoints. Scoliosis Research Society-22 scores improved significantly by 2 years (p < 0.0001).

Conclusion: This was the first prospective, multicenter study to assess outcomes of VBT for patients with AIS. VBT shows promise, but optimal results may depend on careful patient selection and surgical technique. FE major curve magnitude of ≤35° was associated with 88% success rate compared with only 60% success for those with poor correction.

Level of evidence: Level II. See Instructions for Authors for a complete description of levels of evidence.

背景:青少年特发性脊柱侧凸(AIS)的椎体系固术(VBT)是后路融合的一种替代方法。在美国食品和药物管理局批准后,VBT的前瞻性、多中心数据有限。我们假设术后首次站立(首次直立,FE)成像时的曲线矫正与最终随访时更高的矫正成功率相关。方法:前瞻性纳入2019年至2022年间接受胸腰椎VBT治疗的所有符合条件的AIS患者,这些患者来自9个机构。术前、术后及至少2年的最终随访时影像学和临床资料进行比较。成功定义为在最后随访时主弯曲幅度≤35°且未进行融合手术。结果:纳入127例患者,其中女性占79.5%,平均随访2.4年。手术时平均年龄12.9±1.4岁,多数骨龄为Sanders 4及以下(93/112,83.0%)。平均有7.6±1.7个水平被栓住。术前平均主曲线幅度为50±8°,平均FE初始校正为29±8°(校正%,39±18%)。在最后随访时,尽管有29%的系绳断裂,平均曲线幅度维持在26±11°(%矫正,45±23%)。平均FE曲线大小≤35°的患者成功率为88%,而平均FE曲线大小≤35°的患者成功率仅为60% (p = 0.0021)。患者在所有时间点均表现出稳定的矢状位对齐。脊柱侧凸研究学会-22评分在2年后显著提高(p < 0.0001)。结论:这是首个评估AIS患者VBT预后的前瞻性多中心研究。VBT有希望,但最佳结果可能取决于仔细的患者选择和手术技术。FE主曲线大小≤35°与88%的成功率相关,而校正不良的成功率仅为60%。证据等级:二级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Weight and Infantile Blount Disease: Insights from a Rural Ghanaian Cohort. 体重和婴儿布朗特病:来自加纳农村队列的见解。
IF 3.8 Q2 ORTHOPEDICS Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI: 10.2106/JBJS.OA.25.00310
Niels Jansen, Frans Bovendeert, Merel Klaassens, Prosper Moh, Heleen Staal

Background: Blount disease is growth disorder of the proximal tibia, resulting in genu varum, internal rotation, and procurvatum. Three different forms of the condition are described: infantile, or early onset, juvenile onset, and adolescent or late onset. Although several hypotheses exist, the etiology of Blount disease remains unknown. The best-founded hypothesis is the "increased mechanical force hypothesis". In particular, the relation between obesity and Blount disease. Although, most studies supporting this hypothesis are conducted in high income countries. However, unlike in the Western population that was studied to establish this hypothesis, Blount disease is relatively common in African countries and obesity is not.

Methods: This study is a retrospective, case control study in a rural hospital in Ghana (2012-2021). Demographic information, body weight, and age at presentation were collected. The World Health Organization (WHO) weight-for-age growth standard was used. Overweight was defined as a percentile between 85th and 97th. Obese as a percentile between 97th and 99th. Above the 99th percentile was defined as severely obese.

Results: In total 96 patients with infantile Blount disease were included, all of black Ghanaian descent. The mean age of onset of Blount disease in our patients was 1.7 (±0.9) years, and the mean age at presentation was 6.3 (±3.4) years. This was not different between boys (n = 27) and girls (n = 69). The mean weight for age percentile in our population was 56.8th (±35.3th), and 68% was of normal weight, 15% overweight, 8% obese, and 9% severely obese. Our study population had a significant (p < 0.05) higher mean weight percentile compared with the local control group (n = 79, 37.0th ± 26.0th).

Conclusion: Although our study population of patients with infantile Blount was significantly heavier compared with the control group, the mean weight (56.8th ± 35.3th) was well within normal values. Obesity might have a role in the development of infantile Blount disease, but it is shown to be not as an important factor in the Ghanaian population (18% obese) compared with the more extensively studied US population with much higher obesity rates.

Level of evidence: Level III. See Instructions for Authors for a complete description of levels of evidence.

背景:布朗特病是胫骨近端生长障碍,导致膝内翻、内旋和膝前突。描述了三种不同形式的病症:婴儿或早发,青少年发作,青少年或晚发。虽然存在几种假设,但布朗特病的病因尚不清楚。最有根据的假说是“机械力增加假说”。特别是肥胖和布朗特病之间的关系。尽管大多数支持这一假设的研究都是在高收入国家进行的。然而,与为建立这一假设而研究的西方人群不同,布朗特病在非洲国家相对常见,而肥胖则不然。方法:本研究是一项回顾性病例对照研究,于2012-2021年在加纳一家农村医院进行。收集了人口统计信息、体重和就诊时的年龄。采用世界卫生组织(WHO)年龄体重增长标准。超重的定义是百分位数在85到97之间。肥胖的百分位数在97到99之间。超过99个百分位数被定义为严重肥胖。结果:共纳入96例婴儿布朗特病患者,均为加纳黑人后裔。布朗特病的平均发病年龄为1.7(±0.9)岁,平均发病年龄为6.3(±3.4)岁。这在男孩(n = 27)和女孩(n = 69)之间没有差异。年龄百分位数的平均体重为56.8(±35.3),68%为正常体重,15%为超重,8%为肥胖,9%为严重肥胖。与当地对照组相比,我们的研究人群的平均体重百分位数显著(p < 0.05)提高(n = 79, 37.0±26.0)。结论:虽然我们的研究人群的婴儿布朗特患者明显比对照组重,但平均体重(56.8±35.3)完全在正常值范围内。肥胖可能在婴儿布朗特病的发展中起作用,但与更广泛研究的肥胖率更高的美国人口相比,它在加纳人口(18%肥胖率)中被证明不是一个重要因素。证据等级:三级。有关证据水平的完整描述,请参见作者说明。
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