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The effect of teacher-made simulation moulage on learning cricothyrotomy skills in emergency medicine physicians 教师制作模拟软骨对急诊科医师环形切口技能学习的影响
Q3 Nursing Pub Date : 2021-04-09 DOI: 10.34172/JEPT.2021.10
Hamid Reza Moretza-Bagi, A. Ghaffarzad, Peyman Fathipour, R. Yazdani, Z. Khamnian, Sama Rahnemayan
Objective: Nowadays, simulation of clinical environment in medical education system (simulation-based learning) has led to a huge revolution in the quality of education and has increased the safety of educators and patients. In this study, we investigated the effect of teacher-made neck and lung simulators in teaching cricothyrotomy skills for emergency medicine residents. Methods: In this pre-post test study, all faculty member of emergency medicine of Tabriz University of medical sciences specialty were invited to participate. After holding an educational and training session for assistants on a teacher-made moulage, all emergency medicine residents performed a tracheostomy on the commercial moulages of the skill lab unit for the second time and their scores were recorded. Results: In this study, 23 emergency medicine residents participated. The mean±standard deviation of age was 35.91±3.57 years. There was a significant difference between the mean duration of cricothyrotomy before and after the training (P value=0.006). There was also a significant difference between the mean scores obtained by residents in the pre-and post-training evaluation (P value<0.001). Conclusion: Findings showed that the moulages constructed by teachers not only can be effective in improving the cricothyrotomy skills in emergency medicine residents but also can reduce the likelihood of failure in performing cricothyrotomy.
目的:目前,医学教育系统中临床环境的模拟(模拟学习)导致了教育质量的巨大变革,提高了教育者和患者的安全性。在本研究中,我们探讨了教师自制的颈肺模拟器在教授急诊住院医师环甲切开术技能中的效果。方法:采用前后测试研究方法,邀请大不里士医科大学急诊医学专业全体教师参与。在对教师制作的模模进行教育和培训后,所有急诊住院医师第二次在技能实验室单元的商业模模上进行气管切开术,并记录他们的分数。结果:本研究共有23名急诊科住院医师参与。年龄的平均值±标准差为35.91±3.57岁。训练前后环甲环切开术的平均时间差异有统计学意义(P值=0.006)。住院医师在训练前和训练后的平均得分也有显著差异(P值<0.001)。结论:教师构建的教学模式不仅能有效提高急诊医学住院医师环甲环切开术技能,还能降低环甲环切开术失败的可能性。
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引用次数: 1
An unusual case of both bones forearm shaft fracture with ipsilateral distal radio-ulnar joint disruption 一例不寻常的前臂骨干骨折伴同侧尺桡远端关节断裂
Q3 Nursing Pub Date : 2021-03-30 DOI: 10.34172/jept.2021.12
A. Sharma, A. Singhal, Anurag Patil, G. Masih
Objective: Distal radioulnar joint (DRUJ) subluxation with associated both bones forearm fracture is a rare clinical entity and is easily missed, leading to significant functional limitations. Case Presentation: A 28-year-old male fell on the outstretched hand and suffered left side both bones forearm shaft fracture with ipsilateral DRUJ disruption. Operative intervention in the form of plating was done for both bones forearm shaft fracture and DRUJ was stabilised with one k wire and above elbow plaster splint in full supination was given for 6 weeks. At one-year follow-up, fracture was united and Disabilities of the Arm, Shoulder and Hand (DASH) score was 11.7, and he was well satisfied. Conclusion: DRUJ disruption should be carefully evaluated in all the patients with associated shaft fractures of radius and ulna. Timely diagnosis and optimal intervention may prevent any functional limitations.
目的:远端尺桡关节(DRUJ)半脱位合并两骨前臂骨折是一种罕见的临床症状,容易漏诊,导致严重的功能限制。病例介绍:一名28岁男性,伸直手跌倒,左侧双骨前臂轴骨折,同侧DRUJ断裂。以钢板形式对两骨前臂轴骨折进行手术干预,用一根k线固定DRUJ,肘关节以上石膏夹板完全旋后,持续6周。随访1年,骨折愈合,臂肩手残疾(DASH)评分为11.7分,患者满意。结论:所有合并桡骨和尺骨干骨折的患者都应仔细评估DRUJ的破坏情况。及时诊断和最佳干预可以防止任何功能限制。
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引用次数: 0
The effect of a short ultrasound training course on the performance of emergency medical technicians in terms of using extended-focused assessment with sonography in trauma (E-FAST) in the pre-hospital setting 短期超声培训课程对急诊医疗技术人员在院前使用创伤超声扩展聚焦评估(E-FAST)方面的表现的影响
Q3 Nursing Pub Date : 2021-03-09 DOI: 10.34172/JEPT.2021.09
Anita Sabzghabaei, Fariba Farahi, Masoud Ghanbari Boroujeni, H. Hatamabadi
Objective: The aim of this study was to determine the effect of an ultrasound training course on the performance of emergency medical technicians (EMTs) in terms of using extended-focused assessment with sonography in trauma (E-FAST) in the pre-hospital setting. Methods: In this quasi-experimental study, 107 EMTs affiliated to Shahid Beheshti and Kashan Universities of Medical Sciences, were randomly selected. At first, the EMTs were given a pre-test of five images concerning normal and abnormal ultrasound views of thoracic and abdominal cavities. Then, 6 hours of theoretical and practical sessions were done by emergency medicine specialists to teach the EMTs to use ultrasound for the detection of pneumothorax and free fluid. The EMTs were tested again in the form of 18 images post-test as well as a 13-item survey to evaluate their skills in taking correct 10 E-FAST. Results: A total of 107 EMTs with the mean age of 27±15.21 and average of 3.5 years work experience participated in this study. The mean of test score increased from 0.57± 0.19 to 0.81±0.08 (with P < 0.001) out of the total score of 100. In the 4-graded survey, 98% of EMTs obtained good to excellent grades in working with ultrasound machine. Also, 50.5% of EMTs were good in taking Morison’s view and 46.6% and 45.6% had medium grades in pericardial and splenorenal views, respectively. In addition, 22.3% had weak grades in taking pericardial views. Conclusion: The results of the present study showed that the implementation of the training course significantly improved the accuracy of free fluid detection in thoracic and abdominal cavities by EMTs.
目的:本研究的目的是确定超声培训课程对急诊医疗技术人员(emt)在院前使用创伤超声扩展聚焦评估(E-FAST)方面的表现的影响。方法:在准实验研究中,随机抽取沙希德·贝赫什蒂和喀山医科大学附属的107名急诊医师。首先,emt接受了五张关于胸腔和腹腔正常和异常超声图像的预测试。然后,由急诊医学专家进行6小时的理论和实践课程,教emt使用超声波检测气胸和游离液。急救医生在测试后再次接受了18张图片的测试,并进行了一项13项的调查,以评估他们正确选择10张E-FAST的技能。结果:共有107名急诊医师参与本研究,平均年龄(27±15.21)岁,平均工作年限3.5年。在总分100分中,测试分数的平均值由0.57±0.19上升至0.81±0.08 (P < 0.001)。在4个等级的调查中,98%的急救医生在超声机操作方面取得了良好到优秀的成绩。此外,50.5%的EMTs在莫里森观上表现良好,46.6%和45.6%的EMTs在心包观和脾肾观上表现中等。此外,22.3%的患者心包造影评分较低。结论:本研究结果表明,培训课程的实施显著提高了急诊医师胸腹腔游离液检测的准确性。
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引用次数: 0
Penetrating trans-abdominal bamboo stick injury: An unusual case report 穿透性经腹部竹棒伤:罕见病例报告
Q3 Nursing Pub Date : 2021-01-30 DOI: 10.34172/JEPT.2021.04
L. Bansal, Raja Bhanukiran, P. Chaudhary, Arun Gupta
Objective: Penetrating abdominal trauma secondary to bamboo stick injury is a rare entity in the developed world. Most of such kind of trans abdominal penetrating bamboo stick injury is associated with multiple solid and hollow viscus injuries. In developing countries like India, where nearly 70% of the population reside in rural areas, it is not that uncommon. Aim of this report is to recognition of risk factors and explain optimum surgical management in trans-abdominal bamboo stick injury. Case Presentation: Here we describe a case of penetrating trans abdominal bamboo stick injury resulting due to fall over a branch of bamboo stick with multiorgan damage, which was successfully managed by early surgical exploration in our institute. Conclusion: There are many factors which can prognosticate the penetrating trauma cases. The most important factors include a long interval between injury and surgical exploration, presence or absence of shock, and other associated organ injuries at the time of admission. Early recognition of the severity of injury with surgical management is utmost necessary. These patients have high morbidity and mortality rates due to multiorgan damage and post-operative infection.
目的:竹棍伤继发的腹部穿透伤在发达国家是罕见的。这类经腹穿透性竹棒伤多伴有多发实心和空心脏器损伤。在印度这样的发展中国家,近70%的人口居住在农村地区,这并不罕见。本报告旨在探讨经腹竹棍伤的危险因素及最佳手术处理方法。病例介绍:我们在此报告一例穿透性经腹部竹棒损伤,因摔倒在竹棒的分支上而导致多器官损伤,并在我所通过早期手术探查成功处理。结论:影响穿透伤预后的因素有很多。最重要的因素包括损伤和手术探查之间的时间间隔较长,入院时是否存在休克和其他相关器官损伤。早期识别损伤的严重程度和手术处理是非常必要的。由于多器官损伤和术后感染,这些患者的发病率和死亡率都很高。
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引用次数: 0
The proposed scoring system for hospitalization or discharge of patients with COVID-19 新冠肺炎患者住院或出院的拟议评分系统
Q3 Nursing Pub Date : 2021-01-30 DOI: 10.34172/JEPT.2021.08
E. Noori, M. Vahedian, S. Rezvan, Neda Minaei, Reihane Tabaraii
Objective: Since the outbreak of coronavirus disease 2019 (COVID-19), the triage of patients diagnosed with corona virus has been a very important issue. The aim of this study was to introduce a triage scoring system according to the clinical and para-clinical findings of patients in order to be admitted or discharged with COVID-19. Methods: After confirming the positive polymerase chain reaction (PCR) test for patients, we used a scoring system which included: the age of patient (less than 40 years and>40 years), early vital signs at the time of admission, lab tests including C-reactive protein (CRP), white blood count (WBC), lactate dehydrogenase (LDH), D-dimer, chest imaging findings, comorbidity and shortness of breath. Results: The clinical score obtained for each variable in this scoring system was a number between 0 and 3. The total score was a minimum of 0 and a maximum of 17. A higher score indicated an increase in the intensity and the need for intensive care. These scores were classified into 3 groups: 0-4, 5-10 and above 10. In the next stage, patients were divided into three groups: mild, moderate and severe. In this regard, patients with mild symptoms were suggested to receive home quarantine and home treatment, patients with moderate symptoms were recommended hospitalization and medical care, and finally patients with severe symptoms were inclined to intensive care. Conclusion: In order to treat and manage patients with COVID-19, it is necessary to pay particular attention to clinical and para-clinical findings and prioritize these findings based on the severity and the condition of patients.
目的:自2019冠状病毒病(新冠肺炎)爆发以来,确诊为冠状病毒的患者的分诊一直是一个非常重要的问题。本研究的目的是根据新冠肺炎患者的临床和临床旁发现引入分诊评分系统,以便入院或出院。方法:在确认患者聚合酶链式反应(PCR)检测呈阳性后,我们使用了一个评分系统,该系统包括:患者年龄(小于40岁和>40岁)、入院时的早期生命体征、实验室检测,包括C反应蛋白(CRP)、白细胞计数(WBC)、乳酸脱氢酶(LDH)、D-二聚体、胸部影像学检查结果、合并症和呼吸急促。结果:在该评分系统中,每个变量的临床得分都在0到3之间。总分最低为0分,最高为17分。得分越高,表示强度增加,需要重症监护。将这些分数分为3组:0-4分、5-10分和10分以上。在下一阶段,患者被分为三组:轻度、中度和重度。对此,建议症状较轻的患者接受居家隔离和居家治疗,建议症状中等的患者住院治疗和医疗护理,最终症状较重的患者倾向于重症监护。结论:为了治疗和管理新冠肺炎患者,有必要特别关注临床和临床旁发现,并根据患者的严重程度和病情优先考虑这些发现。
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引用次数: 1
Oral ingestion of lidocaine for suicide: A case report 口服利多卡因自杀1例
Q3 Nursing Pub Date : 2020-10-25 DOI: 10.34172/JEPT.2020.42
Maryam Adimolmasali, Alireza Teimouri, Hamid Reza Mokhtar, Mahdi Foroughian, Parvin Zohoorian Sadr, Mohammad Hossein Kamaloddini
Objective: Systemic toxemia with topical anesthetics could be fatal due to the use of anesthetics in various ways (oral, intravenous, intramuscular, or subcutaneous). Nowadays, topical anesthetics are used in inpatient and outpatient treatments. Despite its widespread usage, many physicians are not fully aware of the deadly side effects of lidocaine poisoning and its treatment. The objective of this case report is to highlight the diagnosis and treatment of lidocaine toxicity. Case Presentation: A 21-year-old woman with a history of multiple suicide attempts ingested approximately three 10% w/w lidocaine sprays. The patient was brought to the emergency department of Imam Reza hospital of Mashhad University of Medical Science with cardiac arrest and respiratory failure. After successful cardiopulmonary resuscitation (CPR), she was admitted to the intensive care unit (ICU). She stayed in ICU for 2 days and we administered dobutamine drip and intravenous lipid emulsion for her then she was transferred to the general ward. We discharged her after 8 days. Conclusion: Using BCLS and ACLS in case of cardiac arrest and administration of Lipid Emulsion with proper dosage are recommended treatments for lidocaine toxicity.
目的:由于以各种方式(口服、静脉内、肌肉内或皮下)使用麻醉剂,局部麻醉剂引起的全身毒血症可能是致命的。如今,局部麻醉剂被用于住院和门诊治疗。尽管利多卡因被广泛使用,但许多医生并没有完全意识到利多卡因中毒及其治疗的致命副作用。本病例报告的目的是强调利多卡因毒性的诊断和治疗。病例介绍:一名有多次自杀史的21岁女性摄入了大约三种10%w/w的利多卡因喷雾剂。患者因心脏骤停和呼吸衰竭被送往马什哈德医科大学伊玛目礼萨医院急诊科。心肺复苏术成功后,她住进了重症监护室。她在重症监护室住了2天,我们为她滴注多巴酚丁胺和静脉注射脂质乳剂,然后她被转移到普通病房。8天后我们让她出院。结论:BCLS和ACLS用于心脏骤停和适当剂量的脂质乳剂给药是治疗利多卡因毒性的推荐方法。
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引用次数: 2
Ranking the acute poisoning etiologies in Iran: A systematic review and meta-analysis 伊朗急性中毒病因排序:系统回顾和荟萃分析
Q3 Nursing Pub Date : 2020-10-22 DOI: 10.34172/JEPT.2020.40
Saeedeh Derhami, Ehsan Bolvardi, R. Akhavan, Mahdi Foroughian, Behzad Shahi, Arman Hakemi, Z. Rahmanian, S. Abiri
Objective: Acute poisoning is a major health problem and one of the most common causes of emergency visits worldwide. Since most poisoning subjects present with a decreased level of consciousness and due to unreliable disease history, recognizing the etiological cause of the poisoning represents a critical part in arranging the treatment strategy. This study aimed at examining the prevalence of etiological causes of poisoning in Iran in a systematic review and meta-analysis. Method: This systematic review and meta-analysis investigated the cross-sectional studies published from 1990 to 2020, reporting specific poisoning agents among acute poisoning cases in Iran. Persian and English articles on this subject were collected by searching the Scientific Information Database (SID), ScienceDirect, PubMed, Medlib, IranMedex, Scopus, Magiran, and Google Scholar databases. The heterogeneity of the studies was investigated using the I2 index and the probability of bias in the publication was assessed by the Begg and Mazumdar test with a significance level of 0.1. Data analysis was performed by Comprehensive Meta-analysis software version 3 (Biostat, Englewood, NJ, USA). Results: In our review, 19 studies appraising 143,251 cases of poisoning were included. The ranking of the OR of each agent was done; Opium poisoning was the most prevalent poisoning case followed by benzodiazepine, acetaminophen, antipsychotic medications, organophosphates, aluminum phosphide, amphetamine, pesticide, tricyclic antidepressant (TCA), alcohol, chemicals, carbon monoxide (CO), nonsteroidal anti-inflammatory drugs (NSAIDs), and selective serotonin reuptake inhibitors (SSRIs). Conclusion: While proper judgment on the cause of poisoning and selection of suitable treatment manners could be followed by a very good prognosis in patients with acute poisoning; this demands an epidemiological perception of the prevalence of the etiological poisoning agents. Our study ranked the most likely agents leading to the poisoning, to be at the top of the list of differential diagnoses of physicians.
目的:急性中毒是一个主要的健康问题,也是世界各地急诊就诊最常见的原因之一。由于大多数中毒受试者的意识水平下降,并且病史不可靠,因此识别中毒的病因是安排治疗策略的关键部分。本研究旨在通过系统综述和荟萃分析来检查伊朗中毒病因的流行情况。方法:这项系统综述和荟萃分析调查了1990年至2020年发表的横断面研究,报告了伊朗急性中毒病例中的特定中毒剂。通过搜索科学信息数据库(SID)、ScienceDirect、PubMed、Medlib、IranMedex、Scopus、Magiran和Google Scholar数据库收集有关该主题的波斯语和英语文章。使用I2指数调查研究的异质性,并通过Begg和Mazumdar检验评估出版物中的偏倚概率,显著性水平为0.1。通过综合荟萃分析软件版本3(Biostat,Englewood,NJ,USA)进行数据分析。结果:在我们的综述中,19项研究评估了143251例中毒病例。对每个代理人的OR进行排名;鸦片中毒是最常见的中毒病例,其次是苯二氮卓类药物、对乙酰氨基酚、抗精神病药物、有机磷酸酯、磷化铝、苯丙胺、农药、三环类抗抑郁药、酒精、化学品、一氧化碳、非甾体抗炎药和选择性血清素再摄取抑制剂。结论:正确判断中毒原因,选择合适的治疗方法,可使急性中毒患者预后良好;这就需要对病原性中毒剂的流行情况有一个流行病学的认识。我们的研究将最有可能导致中毒的药物列为医生鉴别诊断的首位。
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引用次数: 0
Delirium treatment in intoxicated patients in ICU: A randomized, double-blind clinical trial ICU中毒患者谵妄的治疗:一项随机、双盲临床试验
Q3 Nursing Pub Date : 2020-10-21 DOI: 10.34172/JEPT.2020.41
Javad Mesbahi, S. Shadnia, H. Hassanian‐Moghaddam, N. Zamani, Peyman Erfan Talab Evini, Delara Hazegh Fetratjoo, A. Kargar, Mitra Rahimi
Objective: Delirium is one of the most common complications in patients admitted to intensive care units (ICUs). Delirium is a definite cause for more extended hospital stays, higher mortality rates, and possibly persistent cognitive decline in the future. Antipsychotics have been frequently evaluated as first drugs of choice, but the most appropriate, evidence-based treatment is yet to be discovered. This study aims to compare the efficacy of haloperidol and olanzapine in patients admitted to our toxicology ICU. Methods: This double-blind, randomized controlled clinical trial was undertaken on 35 ICU admitted patients with delirium in Loghman Hakim hospital in Tehran, Iran. The diagnosis was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for delirium, and clinical toxicologists included the patients according to the study’s inclusion and exclusion criteria. Patients received either haloperidol or olanzapine based on computerized randomization. The severity of delirium was measured with the Memorial Delirium Assessment Scale (MDAS) scoring on days 0 and 3 of ICU-admission. Results: The total sample size was 35 in which 16 patients received haloperidol, and 19 patients received olanzapine. The doses of haloperidol and olanzapine were 3 mg three times a day and 5 mg three times a day, respectively. There was no significant difference in baseline characteristics and the scores of MDAS between groups. Conclusion: Olanzapine and haloperidol have the same efficacy in the management of delirium in toxicology ICU-admitted patients. They can be interchangeably used for delirium treatment in these patients.
目的:谵妄是入住重症监护室(ICU)患者最常见的并发症之一。谵妄是导致住院时间延长、死亡率升高以及未来认知能力持续下降的确切原因。抗精神病药物经常被评估为首选药物,但最合适的循证治疗方法尚待发现。本研究旨在比较氟哌啶醇和奥氮平对我们毒理学ICU患者的疗效。方法:对伊朗德黑兰Loghman Hakim医院35名ICU住院的谵妄患者进行双盲、随机对照临床试验。诊断基于《精神障碍诊断与统计手册》第五版(DSM-V)的谵妄标准,临床毒理学家根据研究的纳入和排除标准将患者纳入。根据计算机随机分组,患者接受氟哌啶醇或奥氮平治疗。在入住ICU的第0天和第3天,用纪念性谵妄评估量表(MDAS)评分来测量谵妄的严重程度。结果:总样本量为35,其中16名患者接受氟哌啶醇治疗,19名患者接受奥氮平治疗。氟哌啶醇和奥氮平的剂量分别为每天3次3毫克和每天3次5毫克。各组间基线特征和MDAS评分无显著差异。结论:奥氮平与氟哌啶醇治疗毒理学ICU住院患者谵妄疗效相同。它们可以互换用于这些患者的谵妄治疗。
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引用次数: 1
Underlying causes of pulled elbow in children: Could there be a physiopathology similar to transient synovitis of the hip? 儿童肘关节扭伤的根本原因:是否存在类似于髋关节短暂滑膜炎的生理病理学?
Q3 Nursing Pub Date : 2020-10-20 DOI: 10.34172/JEPT.2020.39
Raheleh Faramarzi, M. Sharifi, E. Moradi, B. Alizadeh
Objective: Partial dislocation of radius head (pulled elbow) is the most common trauma observed in out-patient orthopedic treatment of children. The typical mechanism of this trauma includes exertion of longitudinal force along the forearm in a pronation position, causing partial dislocation of the radius head. Methods: This Retrospective descriptive and cross-sectional study was undertaken on patients referring to the emergency ward of Imam Reza hospital of Mashhad with typical history of partial dislocation of radius head (pulled elbow). The present study was conducted between March 20, 2018 and March 20, 2019. Based on the number of patients at the emergency ward, the sample size was determined to be 80. Descriptive statistics such as mean and standard deviation were used to describe the collected data. Results: From among 80 children diagnosed with partial radius bone dislocation, 66.23% were girls and 33.77% were boys. The age range of patients was 28.08 months for girls and 31.04 months for boys. Findings also showed that 32 patients had a history of recent respiratory infection within 1 week before the pulled elbow incident. Conclusion: Findings revealed that, similar to previous studies, the pulled elbow injury was more common in girls than in boys. Successful reduction in first and second attempts, notwithstanding the maneuvers used indicated that the success rate of first attempts at reduction was 93%. The history of recent respiratory infections during 1 week before the injury was taken into account, where 40% of the children had some history of such respiratory infections.
目的:桡骨头部分脱位(牵拉肘)是儿童骨科门诊治疗中最常见的创伤。这种创伤的典型机制包括沿前臂在旋前位施加纵向力,导致桡骨头部分脱位。方法:回顾性、描述性和横断面研究马什哈德伊玛目礼萨医院急诊科收治的桡骨头部分脱位(牵拉肘)患者。本研究是在2018年3月20日至2019年3月20日之间进行的。根据急诊病房的患者数量,确定样本量为80。使用描述性统计,如平均值和标准差来描述收集到的数据。结果:80例桡骨部分脱位患儿中,女孩占66.23%,男孩占33.77%。患者年龄女生28.08个月,男生31.04个月。32例患者在肘部牵拉前1周内有近期呼吸道感染史。结论:研究结果显示,与以往的研究相似,女孩的肘部拉伤比男孩更常见。第一次和第二次尝试的成功复位,尽管使用了机动,表明第一次尝试的成功率为93%。考虑损伤前1周内近期呼吸道感染史,其中40%的儿童有呼吸道感染史。
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引用次数: 0
Diagnostic relevance of neutrophil gelatinase-associated lipocalin in early detection of acute kidney injury 中性粒细胞明胶酶相关脂质运载蛋白在早期检测急性肾损伤中的诊断意义
Q3 Nursing Pub Date : 2020-10-03 DOI: 10.34172/JEPT.2020.38
Madhusudhan Mahadevaiah, Murali Mohan Nidasale Thimmaiah, Venu Sashank Yerramsetty, J. Kumar, Ranjith Kumar
Objective: To evaluate the predictive and diagnostic accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in acute kidney injury (AKI) and also to predict the renal replacement therapy (RRT) using NGAL as a marker. Methods: This prospective study was conducted among the patients admitted to intensive care units. Plasma samples were collected 24 hours after admission and NGAL was measured using Triage® NGAL test, a specific point of care test which is based on the mechanism of fluorescence immunoassay. The diagnostic accuracy of plasma NGAL (pNGAL) to predict AKI in critically ill patients of ICU was assessed by applying receiver operator curve (ROC) analysis and calculating the area under the curve (AUC). Results: In this study, 100 patients with the mean age of 49.56±19.2 years were included for the period of 18 months. The blood samples were withdrawn from the patients 24 and 44 hours after admission. Totally, 55% (n=55) of ICU patients were diagnosed with AKI. Plasma NGAL level was significantly increased in AKI patients as compared to non-AKI patients (742.65±734.72 vs. 255.62±440.09 μg/L; P<0.01). The sensitivity and specificity of NGAL for diagnosing AKI was 83.6% and 88.9%, respectively. The overall diagnostic accuracy was 86%. Diagnostic accuracy of NGAL for requirement of RRT was 51%. Conclusion: Plasma NGAL is a reliable marker for patients with AKI in ICU, in case the cause of kidney injury is not known. In addition, NGAL also predicts the RRT need based on AKI severity.
目的:评价中性粒细胞明胶酶相关脂钙素(NGAL)对急性肾损伤(AKI)的预测和诊断准确性,并以NGAL为指标预测肾替代治疗(RRT)。方法:本前瞻性研究在重症监护病房住院患者中进行。入院后24小时采集血浆样本,使用Triage®NGAL测试测量NGAL,这是一种基于荧光免疫测定机制的特定护理点测试。应用受试者操作曲线(receiver operator curve, ROC)分析并计算曲线下面积(area under The curve, AUC),评价血浆NGAL (pNGAL)对ICU危重患者AKI的诊断准确性。结果:本研究纳入100例患者,平均年龄49.56±19.2岁,时间18个月。分别于入院后24小时和44小时抽取患者血样。共有55% (n=55)的ICU患者被诊断为AKI。AKI患者血浆NGAL水平显著高于非AKI患者(742.65±734.72∶255.62±440.09 μg/L;P < 0.01)。NGAL诊断AKI的敏感性和特异性分别为83.6%和88.9%。总体诊断准确率为86%。NGAL对RRT要求的诊断准确率为51%。结论:在肾损伤原因不明的情况下,血浆NGAL是ICU AKI患者的可靠标志物。此外,NGAL还可根据AKI严重程度预测RRT需求。
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引用次数: 2
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Journal of Emergency Practice and Trauma
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